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HSP40/DnaJ peptide-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   HSP40/DnaJ peptide-binding domain [ 49492]
Superfamily:   HSP40/DnaJ peptide-binding domain [ 49493]
Families:   HSP40/DnaJ peptide-binding domain [ 49494] (2)

Superfamily statistics
Genomes (2,395) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 14,412 30,162 6
Proteins 7,468 15,542 3

 Functional annotation
General category Processes_IC
Detailed category Proteases

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 3.125e-07 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 4.385e-06 Least Informative Direct
Biological Process (BP) response to stimulus 0.0006458 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.4594 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 0.3849 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.8808 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9655 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.5826 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.0009203 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.01584 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1677 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.1574 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.09141 Moderately Informative Inherited
Biological Process (BP) reproduction 0.08104 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2303 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.7725 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0.00026 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0002284 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.001234 Informative Inherited
Biological Process (BP) cellular component movement 0.01427 Informative Inherited
Biological Process (BP) locomotion 0.04089 Informative Inherited
Biological Process (BP) localization of cell 0.003416 Informative Inherited
Biological Process (BP) sexual reproduction 0.00236 Informative Inherited
Biological Process (BP) single organism reproductive process 0.003862 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.008495 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 4.026e-05 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0002229 Highly Informative Direct
Biological Process (BP) response to heat 4.844e-12 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 8.659e-05 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 7.399e-09 Highly Informative Direct
Molecular Function (MF) binding 0.1135 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.002553 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.005448 Moderately Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.06239Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.0007733Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA replication0InformativeDirect
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionZinc-finger0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationMethylation1.942e-07Moderately InformativeDirect
Post-translational modificationPrenylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008971 SSF49493 Protein matches
Abstract

The Escherichia coli Hsp40 DnaJ and Hsp70 DnaK cooperate in the binding of proteins at intermediate stages of folding, assembly, and translocation across membranes [PubMed9600925]. Binding of protein substrates to the DnaK C-terminal domain is controlled by ATP binding and hydrolysis in the N-terminal ATPase domain. The interaction of DnaJ with DnaK is mediated at least in part by the highly conserved N-terminal J-domain of DnaJ. The J-domain interaction is localized to the ATPase domain of DnaK and is likely to be dominated by electrostatic interactions. J-domain may tether DnaK to DnaJ-bound substrates, which DnaK then binds with its C-terminal peptide-binding domain. The peptide-binding domain of DnaJ is comprised of a beta sandwich made up of 6 beta-strands divided into 2 sheets.


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HSP40/DnaJ peptide-binding domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the HSP40/DnaJ peptide-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.