SUPERFAMILY 1.75 HMM library and genome assignments server


HSP40/DnaJ peptide-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   HSP40/DnaJ peptide-binding domain [ 49492]
Superfamily:   HSP40/DnaJ peptide-binding domain [ 49493]
Families:   HSP40/DnaJ peptide-binding domain [ 49494] (2)


Superfamily statistics
Genomes (3,147) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 17,594 58,640 6
Proteins 9,104 29,985 3


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 2.585e-07 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.146e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.8127 Least Informative Inherited
Biological Process (BP) localization 0.05729 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.3216 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.1003 Least Informative Inherited
Biological Process (BP) response to stimulus 0.002915 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.8731 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9405 Least Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1.846e-05 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 1.322e-05 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.01637 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01943 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.006698 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1549 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.4864 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.9717 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2099 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.4715 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.09153 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.2974 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9232 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.4201 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.005138 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0777 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2397 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0.000264 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0002858 Informative Direct
Biological Process (BP) regulation of kinase activity 0.0004719 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0001652 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0002691 Informative Direct
Biological Process (BP) protein localization to organelle 0.1226 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.2095 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.002409 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.005132 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.004039 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.004726 Informative Inherited
Biological Process (BP) cellular component movement 0.04362 Informative Inherited
Biological Process (BP) locomotion 0.04023 Informative Inherited
Biological Process (BP) localization of cell 0.01551 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.01121 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01475 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01885 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01427 Informative Inherited
Biological Process (BP) sexual reproduction 0.003328 Informative Inherited
Biological Process (BP) single organism reproductive process 0.00464 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01139 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 6.31e-05 Highly Informative Direct
Biological Process (BP) response to heat 5.55e-10 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0008771 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 6.226e-11 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0006227 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 5.012e-10 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.003985 Highly Informative Inherited
Molecular Function (MF) binding 0.003214 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0003418 Moderately Informative Direct
Molecular Function (MF) enzyme activator activity 0.02206 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 3.222e-06 Least Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.06239Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.0007733Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA replication0InformativeDirect
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationMethylation3.445e-07Moderately InformativeDirect
Post-translational modificationPrenylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008971 SSF49493 Protein matches
Abstract

The Escherichia coli Hsp40 DnaJ and Hsp70 DnaK cooperate in the binding of proteins at intermediate stages of folding, assembly, and translocation across membranes [PubMed9600925]. Binding of protein substrates to the DnaK C-terminal domain is controlled by ATP binding and hydrolysis in the N-terminal ATPase domain. The interaction of DnaJ with DnaK is mediated at least in part by the highly conserved N-terminal J-domain of DnaJ. The J-domain interaction is localized to the ATPase domain of DnaK and is likely to be dominated by electrostatic interactions. J-domain may tether DnaK to DnaJ-bound substrates, which DnaK then binds with its C-terminal peptide-binding domain. The peptide-binding domain of DnaJ is comprised of a beta sandwich made up of 6 beta-strands divided into 2 sheets.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HSP40/DnaJ peptide-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the HSP40/DnaJ peptide-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]