SUPERFAMILY 1.75 HMM library and genome assignments server


HSP40/DnaJ peptide-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   HSP40/DnaJ peptide-binding domain [ 49492]
Superfamily:   HSP40/DnaJ peptide-binding domain [ 49493]
Families:   HSP40/DnaJ peptide-binding domain [ 49494] (2)


Superfamily statistics
Genomes (3,141) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 17,275 58,640 6
Proteins 8,928 29,985 3


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 7.311e-07 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 4.376e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.8102 Least Informative Inherited
Biological Process (BP) localization 0.09151 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.3283 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.1041 Least Informative Inherited
Biological Process (BP) response to stimulus 0.007374 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.9594 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9951 Least Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 3.467e-05 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 2.731e-05 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.01576 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.02791 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1455 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.4856 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.9646 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2116 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.473 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.09093 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.2942 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9209 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.4725 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.005135 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1017 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2948 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0.0003589 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0002734 Informative Direct
Biological Process (BP) regulation of kinase activity 0.0006807 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000236 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0003715 Informative Direct
Biological Process (BP) protein localization to organelle 0.1297 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.2089 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.003344 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.005027 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.003886 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.004685 Informative Inherited
Biological Process (BP) cellular component movement 0.05706 Informative Inherited
Biological Process (BP) locomotion 0.0522 Informative Inherited
Biological Process (BP) localization of cell 0.01541 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.01356 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01812 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01815 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01432 Informative Inherited
Biological Process (BP) sexual reproduction 0.003475 Informative Inherited
Biological Process (BP) single organism reproductive process 0.006443 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.0115 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 9.019e-05 Highly Informative Direct
Biological Process (BP) response to heat 5.537e-10 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0008467 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 6.803e-11 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0005914 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 7.462e-10 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.003833 Highly Informative Inherited
Molecular Function (MF) binding 0.01021 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0005117 Moderately Informative Direct
Molecular Function (MF) enzyme activator activity 0.02171 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1.525e-05 Least Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.06239Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.0007733Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA replication0InformativeDirect
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationMethylation3.526e-07Moderately InformativeDirect
Post-translational modificationPrenylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008971 SSF49493 Protein matches
Abstract

The Escherichia coli Hsp40 DnaJ and Hsp70 DnaK cooperate in the binding of proteins at intermediate stages of folding, assembly, and translocation across membranes [PubMed9600925]. Binding of protein substrates to the DnaK C-terminal domain is controlled by ATP binding and hydrolysis in the N-terminal ATPase domain. The interaction of DnaJ with DnaK is mediated at least in part by the highly conserved N-terminal J-domain of DnaJ. The J-domain interaction is localized to the ATPase domain of DnaK and is likely to be dominated by electrostatic interactions. J-domain may tether DnaK to DnaJ-bound substrates, which DnaK then binds with its C-terminal peptide-binding domain. The peptide-binding domain of DnaJ is comprised of a beta sandwich made up of 6 beta-strands divided into 2 sheets.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HSP40/DnaJ peptide-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the HSP40/DnaJ peptide-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]