SUPERFAMILY 1.75 HMM library and genome assignments server


HSP40/DnaJ peptide-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   HSP40/DnaJ peptide-binding domain [ 49492]
Superfamily:   HSP40/DnaJ peptide-binding domain [ 49493]
Families:   HSP40/DnaJ peptide-binding domain [ 49494] (2)


Superfamily statistics
Genomes (3,106) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 16,626 30,162 6
Proteins 8,585 15,542 3


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 2.185e-07 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.985e-06 Least Informative Direct
Biological Process (BP) response to stimulus 0.0002422 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.8206 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.4502 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9895 Least Informative Inherited
Biological Process (BP) localization 0.1582 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.6973 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.811 Least Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.009977 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.006361 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1517 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.09312 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.1151 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.002305 Moderately Informative Inherited
Biological Process (BP) reproduction 0.04957 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.1642 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0.0002 Informative Direct
Biological Process (BP) regulation of nucleotide catabolic process 0.0003672 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.001122 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.001316 Informative Inherited
Biological Process (BP) cellular component movement 0.02742 Informative Inherited
Biological Process (BP) locomotion 0.02545 Informative Inherited
Biological Process (BP) localization of cell 0.003852 Informative Inherited
Biological Process (BP) sexual reproduction 0.003193 Informative Inherited
Biological Process (BP) single organism reproductive process 0.002547 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01102 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 3.599e-05 Highly Informative Direct
Biological Process (BP) response to heat 5.424e-11 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 1.602e-10 Highly Informative Direct
Molecular Function (MF) binding 0.007467 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.001106 Moderately Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 5.236e-07 Least Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.06239Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.0007733Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA replication0InformativeDirect
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationMethylation3.381e-07Moderately InformativeDirect
Post-translational modificationPrenylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008971 SSF49493 Protein matches
Abstract

The Escherichia coli Hsp40 DnaJ and Hsp70 DnaK cooperate in the binding of proteins at intermediate stages of folding, assembly, and translocation across membranes [PubMed9600925]. Binding of protein substrates to the DnaK C-terminal domain is controlled by ATP binding and hydrolysis in the N-terminal ATPase domain. The interaction of DnaJ with DnaK is mediated at least in part by the highly conserved N-terminal J-domain of DnaJ. The J-domain interaction is localized to the ATPase domain of DnaK and is likely to be dominated by electrostatic interactions. J-domain may tether DnaK to DnaJ-bound substrates, which DnaK then binds with its C-terminal peptide-binding domain. The peptide-binding domain of DnaJ is comprised of a beta sandwich made up of 6 beta-strands divided into 2 sheets.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HSP40/DnaJ peptide-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the HSP40/DnaJ peptide-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]