SUPERFAMILY 1.75 HMM library and genome assignments server

HSP40/DnaJ peptide-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   HSP40/DnaJ peptide-binding domain [ 49492]
Superfamily:   HSP40/DnaJ peptide-binding domain [ 49493]
Families:   HSP40/DnaJ peptide-binding domain [ 49494] (2)


Superfamily statistics
Genomes (3,148) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 17,635 58,640 6
Proteins 9,128 29,985 3


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0000002501 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000004519 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.2692 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.6503 Least Informative Inherited
Biological Process (BP) localization 0.05001 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.2923 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.001538 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.8471 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9274 Least Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.00004862 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.00009141 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.3519 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.3928 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.09929 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2375 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.9428 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5372 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1647 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01257 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.9716 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.2837 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.005556 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.03137 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1502 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.4547 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2894 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0.0002137 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0002903 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0003073 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0002342 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.01722 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.03364 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.02843 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1203 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.3522 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.003653 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.03809 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.001611 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.006091 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.003856 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.006533 Informative Inherited
Biological Process (BP) cellular component movement 0.03589 Informative Inherited
Biological Process (BP) locomotion 0.0331 Informative Inherited
Biological Process (BP) localization of cell 0.01396 Informative Inherited
Biological Process (BP) sexual reproduction 0.002721 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.007539 Informative Inherited
Biological Process (BP) single organism reproductive process 0.03107 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.002233 Informative Inherited
Biological Process (BP) negative regulation of protein phosphorylation 0.0004133 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.00005198 Highly Informative Direct
Biological Process (BP) response to heat 0.0000000005865 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.0000000000596 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.000284 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.0000000003795 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0001603 Highly Informative Direct
Molecular Function (MF) binding 0.001661 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0000647 Moderately Informative Direct
Molecular Function (MF) enzyme activator activity 0.07465 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000009168 Least Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.06239Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.0007733Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)heat sensitivity0.0008576InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA replication0InformativeDirect
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationMethylation0.0000003497Moderately InformativeDirect
Post-translational modificationPrenylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008971 SSF49493 Protein matches
Abstract

The Escherichia coli Hsp40 DnaJ and Hsp70 DnaK cooperate in the binding of proteins at intermediate stages of folding, assembly, and translocation across membranes [PubMed9600925]. Binding of protein substrates to the DnaK C-terminal domain is controlled by ATP binding and hydrolysis in the N-terminal ATPase domain. The interaction of DnaJ with DnaK is mediated at least in part by the highly conserved N-terminal J-domain of DnaJ. The J-domain interaction is localized to the ATPase domain of DnaK and is likely to be dominated by electrostatic interactions. J-domain may tether DnaK to DnaJ-bound substrates, which DnaK then binds with its C-terminal peptide-binding domain. The peptide-binding domain of DnaJ is comprised of a beta sandwich made up of 6 beta-strands divided into 2 sheets.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HSP40/DnaJ peptide-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the HSP40/DnaJ peptide-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]