SUPERFAMILY 1.75 HMM library and genome assignments server


Aromatic compound dioxygenase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Prealbumin-like [ 49451] (7)
Superfamily:   Aromatic compound dioxygenase [ 49482]
Families:   Aromatic compound dioxygenase [ 49483] (4)


Superfamily statistics
Genomes (801) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,425 9,320 13
Proteins 2,414 9,294 13


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.019880.5565Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.033370.6571Least InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process9.78e-070.0002274Moderately InformativeDirect
Biological Process (BP)phenol-containing compound metabolic process1.144e-113.455e-09Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity0.00038670.007534Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen2.523e-112.041e-11Highly InformativeDirect
Molecular Function (MF)dioxygenase activity3.845e-101.611e-09Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.5565 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6571 Least Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.0002274 Moderately Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 3.455e-09 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity 0.007534 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 2.041e-11 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 1.611e-09 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen0InformativeDirect
Enzyme Commission (EC)With incorporation of two atoms of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Molecular functionMetal-binding5.233e-06Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDioxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound degradation0.0003612Moderately InformativeDirect
UniPathway (UP)xenobiotic degradation1InformativeInherited
UniPathway (UP)beta-ketoadipate pathway0Highly InformativeDirect
UniPathway (UP)3-chlorocatechol degradation6.185e-12Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR015889 SSF49482 Protein matches
Abstract

Dioxygenases catalyse the incorporation of both atoms of molecular oxygen into substrates using a variety of reaction mechanisms. Cleavage of aromatic rings is one of the most important functions of dioxygenases, which play key roles in the degradation of aromatic compounds. The substrates of ring-cleavage dioxygenases can be classified into two groups according to the mode of scission of the aromatic ring. Intradiol enzymes use a non-haem Fe(III) to cleave the aromatic ring between two hydroxyl groups (ortho-cleavage), whereas extradiol enzymes use a non-haem Fe(II) to cleave the aromatic ring between a hydroxylated carbon and an adjacent non-hydroxylated carbon (meta-cleavage) [PubMed10730195]. These two subfamilies differ in sequence, structural fold, iron ligands, and the orientation of second sphere active site amino acid residues.

Enzymes that belong to the intradiol family include catechol 1,2-dioxygenase (1,2-CTD) ; protocatechuate 3,4-dioxygenase (3,4-PCD) ; and chlorocatechol 1,2-dioxygenase [PubMed15060064].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aromatic compound dioxygenase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Aromatic compound dioxygenase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]