SUPERFAMILY 1.75 HMM library and genome assignments server


p53-like transcription factors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Families:   p53 DNA-binding domain-like [ 81314] (2)
  Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
  T-box [ 81316] (2)
  STAT DNA-binding domain [ 81317] (3)
  RUNT domain [ 81318]
  DNA-binding domain from NDT80 [ 81992]
  DNA-binding protein LAG-1 (CSL) [ 110080]


Superfamily statistics
Genomes (359) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,139 7,648 53
Proteins 6,030 7,570 53


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process6.643e-120Least InformativeDirect
Biological Process (BP)developmental process2.921e-110Least InformativeDirect
Biological Process (BP)regulation of cellular process6.284e-104.471e-12Least InformativeDirect
Biological Process (BP)response to stimulus0.00055150Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.0020Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0066293.77e-15Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.066870Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.068292.125e-14Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.092433.77e-15Least InformativeInherited
Biological Process (BP)biosynthetic process0.092432.385e-07Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.14359.515e-11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.10581.024e-08Least InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process5.008e-140Moderately InformativeDirect
Biological Process (BP)cell differentiation5.124e-130Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process9.169e-060Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process4.761e-050Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process7.56e-050Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.00028926.679e-10Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process0.00042780Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0006580Moderately InformativeDirect
Biological Process (BP)immune system process0.00073490Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.019420.0001291Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death1.718e-060.06133Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0018670Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0024520Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.0026390Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.0042460Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.001060Moderately InformativeInherited
Biological Process (BP)organ development0.0010670Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.033920.0362Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.02870Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.0018160Moderately InformativeInherited
Biological Process (BP)gene expression0.0025290Moderately InformativeInherited
Biological Process (BP)tissue development0.0012138.018e-14Moderately InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process4.862e-060InformativeDirect
Biological Process (BP)transcription, DNA-dependent5.838e-060InformativeDirect
Biological Process (BP)organ morphogenesis5.029e-059.266e-13InformativeDirect
Biological Process (BP)positive regulation of gene expression0.00011690InformativeDirect
Biological Process (BP)embryonic morphogenesis0.00013560InformativeDirect
Biological Process (BP)embryonic organ development0.00017370InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.00021080InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.0003720InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway0.00053068.807e-11InformativeDirect
Biological Process (BP)embryo development ending in birth or egg hatching1.61e-100.1895InformativeInherited
Biological Process (BP)muscle structure development0.0026591.953e-05InformativeInherited
Biological Process (BP)leukocyte activation0.0025192.813e-06InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.013470InformativeInherited
Biological Process (BP)cardiovascular system development0.0092241.784e-14InformativeInherited
Biological Process (BP)hair follicle development1.152e-081.958e-14Highly InformativeDirect
Biological Process (BP)cell fate commitment2.052e-051.269e-14Highly InformativeDirect
Biological Process (BP)pattern specification process8.69e-050Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent0.0001090Highly InformativeDirect
Biological Process (BP)stem cell development0.0002781.629e-12Highly InformativeDirect
Molecular Function (MF)binding1.324e-050Least InformativeDirect
Molecular Function (MF)nucleic acid binding1.133e-130Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding00InformativeDirect
Molecular Function (MF)chromatin binding2.27e-090InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle1.405e-070Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 4.471e-12 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 3.77e-15 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 2.125e-14 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 3.77e-15 Least Informative Direct
Biological Process (BP) biosynthetic process 2.385e-07 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.024e-08 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 9.515e-11 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.5832 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.09037 Least Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 6.679e-10 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) tissue development 8.018e-14 Moderately Informative Direct
Biological Process (BP) multi-organism process 5.255e-07 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 3.646e-08 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0001291 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 2.418e-10 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 1.679e-07 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 3.854e-07 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0002212 Moderately Informative Direct
Biological Process (BP) reproduction 1.585e-08 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.06133 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.01137 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.3712 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001147 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.04608 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.0362 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01314 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.6599 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.01571 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8285 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) organ morphogenesis 9.266e-13 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 0 Informative Direct
Biological Process (BP) embryonic organ development 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 8.807e-11 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0003783 Informative Direct
Biological Process (BP) tissue morphogenesis 2.125e-14 Informative Direct
Biological Process (BP) leukocyte activation 2.813e-06 Informative Direct
Biological Process (BP) muscle structure development 1.953e-05 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) central nervous system development 0.000311 Informative Direct
Biological Process (BP) cardiovascular system development 1.784e-14 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 6.39e-09 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) tube development 2.844e-12 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 2.521e-09 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) intracellular signal transduction 3.969e-14 Informative Direct
Biological Process (BP) response to nutrient levels 6.084e-11 Informative Direct
Biological Process (BP) regulation of peptidase activity 2.271e-10 Informative Direct
Biological Process (BP) regulation of growth 3.366e-10 Informative Direct
Biological Process (BP) immune response 1.667e-09 Informative Direct
Biological Process (BP) gland development 3.003e-09 Informative Direct
Biological Process (BP) mitochondrion organization 1.803e-07 Informative Direct
Biological Process (BP) response to DNA damage stimulus 2.832e-07 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 4.445e-05 Informative Direct
Biological Process (BP) protein localization to organelle 8.774e-05 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0001154 Informative Direct
Biological Process (BP) lipid localization 0.0002302 Informative Direct
Biological Process (BP) protein transport 0.0002446 Informative Direct
Biological Process (BP) DNA metabolic process 0.0003684 Informative Direct
Biological Process (BP) locomotion 0.0003895 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0004897 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0005448 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0006414 Informative Direct
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 0.06209 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.07397 Informative Inherited
Biological Process (BP) negative regulation of transport 0.8804 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.9126 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1536 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.016 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.008359 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.1128 Informative Inherited
Biological Process (BP) response to inorganic substance 0.8942 Informative Inherited
Biological Process (BP) muscle tissue development 0.8246 Informative Inherited
Biological Process (BP) sensory organ development 0.3806 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.03522 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.7986 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.6317 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.5277 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001661 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1895 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) cellular membrane organization 0.1579 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.003368 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.002973 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.9078 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.002754 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.4376 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.4745 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.8652 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01751 Informative Inherited
Biological Process (BP) single organism reproductive process 0.3795 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.01227 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.06229 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.819 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) response to lipid 0.5814 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.08231 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.1241 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.3731 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.649 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) response to other organism 0.9278 Informative Inherited
Biological Process (BP) response to light stimulus 0.1456 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.09075 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.478 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.009372 Informative Inherited
Biological Process (BP) cell cycle process 0.1539 Informative Inherited
Biological Process (BP) metal ion transport 0.08784 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) localization of cell 0.003933 Informative Inherited
Biological Process (BP) cellular component movement 0.7882 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) hair follicle development 1.958e-14 Highly Informative Direct
Biological Process (BP) cell fate commitment 1.269e-14 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) stem cell development 1.629e-12 Highly Informative Direct
Biological Process (BP) skeletal system development 3.932e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) mesenchyme development 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 9.182e-15 Highly Informative Direct
Biological Process (BP) response to UV 6.399e-13 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 4.579e-12 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 7.621e-12 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 9.751e-12 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 2.659e-11 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 2.796e-11 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 1.384e-10 Highly Informative Direct
Biological Process (BP) nuclear import 1.639e-10 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 2.057e-10 Highly Informative Direct
Biological Process (BP) cellular response to radiation 2.56e-09 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 3.5e-09 Highly Informative Direct
Biological Process (BP) protein import 1.001e-08 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 1.173e-08 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 3.813e-08 Highly Informative Direct
Biological Process (BP) mitochondrial transport 4.937e-08 Highly Informative Direct
Biological Process (BP) regulation of autophagy 8.535e-08 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 1.525e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 2.03e-07 Highly Informative Direct
Biological Process (BP) lactation 3.453e-07 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 3.557e-07 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 1.919e-06 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 2.285e-06 Highly Informative Direct
Biological Process (BP) limb morphogenesis 2.594e-06 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 3.657e-06 Highly Informative Direct
Biological Process (BP) renal system development 4.163e-06 Highly Informative Direct
Biological Process (BP) ovulation cycle process 4.463e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 5.012e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 5.748e-06 Highly Informative Direct
Biological Process (BP) angiogenesis 6.079e-06 Highly Informative Direct
Biological Process (BP) cellular response to metal ion 6.465e-06 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 8.695e-06 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 1.043e-05 Highly Informative Direct
Biological Process (BP) cellular response to peptide 1.452e-05 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 1.596e-05 Highly Informative Direct
Biological Process (BP) response to calcium ion 2.767e-05 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 3.458e-05 Highly Informative Direct
Biological Process (BP) stem cell proliferation 8.968e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0001723 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 0.0001849 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 0.0003342 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.0003681 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000423 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.0004286 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0004424 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0006388 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.0006888 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0007002 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 1 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.4818 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.01459 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.01225 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.01291 Highly Informative Inherited
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.00786 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.09709 Highly Informative Inherited
Biological Process (BP) ear development 0.05128 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.7348 Highly Informative Inherited
Biological Process (BP) regulation of calcium-mediated signaling 0.02655 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 1 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.007921 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.5678 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.00218 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.6394 Highly Informative Inherited
Biological Process (BP) cell cycle phase 0.002033 Highly Informative Inherited
Biological Process (BP) sensory perception 0.001374 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.00159 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.00125 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.366 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.8219 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.0105 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.001844 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.04594 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.4413 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.09552 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.8916 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.01606 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphorylation 0.2153 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.81 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.4676 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.01537 Highly Informative Inherited
Biological Process (BP) regulation of cell killing 0.08008 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.671 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.2814 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.1292 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.16 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.5886 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.01544 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.02572 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.8778 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.01564 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.6168 Highly Informative Inherited
Biological Process (BP) positive regulation of epithelial cell proliferation 0.8531 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.02388 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) cell division 0.4984 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.3231 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.003698 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.009016 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.02528 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 1 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.4144 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated immunity 0.4528 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.006911 Highly Informative Inherited
Biological Process (BP) B cell activation 0.8586 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.3172 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.006693 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.5369 Highly Informative Inherited
Biological Process (BP) ossification 0.3164 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.8016 Highly Informative Inherited
Biological Process (BP) gonad development 0.435 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) cation binding 8.812e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 0.003687 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.4511 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 2.03e-08 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 5.129e-08 Informative Direct
Molecular Function (MF) nucleotide binding 1.456e-05 Informative Direct
Molecular Function (MF) protein dimerization activity 3.76e-05 Informative Direct
Molecular Function (MF) transition metal ion binding 9.481e-05 Informative Direct
Molecular Function (MF) enzyme binding 0.02824 Informative Inherited
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) copper ion binding 1.055e-12 Highly Informative Direct
Molecular Function (MF) ATP binding 1.741e-11 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 2.226e-06 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 2.4e-06 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0367 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 8.302e-06 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.4355 Least Informative Inherited
Cellular Component (CC) cytosol 9.131e-15 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.01935 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 2.444e-06 Informative Direct
Cellular Component (CC) nucleolus 4.366e-06 Informative Direct
Cellular Component (CC) chromosome 0.0009758 Informative Direct
Cellular Component (CC) extracellular matrix 0.1727 Informative Inherited
Cellular Component (CC) extracellular matrix part 0.006031 Highly Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.01848 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.08292Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.001519Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.01174Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.01705Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.02432Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.1163Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease2.638e-06InformativeDirect
Disease Ontology (DO)chronic leukemia0.0003471InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.0004875InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.0006007InformativeDirect
Disease Ontology (DO)physical disorder0.001048InformativeInherited
Disease Ontology (DO)lymphoma0.007926InformativeInherited
Disease Ontology (DO)colorectal cancer0.008297InformativeInherited
Disease Ontology (DO)esophageal disease0.008408InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.01095InformativeInherited
Disease Ontology (DO)viral infectious disease0.2662InformativeInherited
Disease Ontology (DO)breast carcinoma0.2967InformativeInherited
Disease Ontology (DO)ulcerative colitis7.997e-08Highly InformativeDirect
Disease Ontology (DO)Burkitt's lymphoma3.838e-05Highly InformativeDirect
Disease Ontology (DO)mumps8.908e-05Highly InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0004775Highly InformativeDirect
Disease Ontology (DO)pertussis0.0005245Highly InformativeDirect
Disease Ontology (DO)hemangioma0.0006084Highly InformativeDirect
Disease Ontology (DO)stomach disease0.005431Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.1232Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7777Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.02042Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.1966Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the hand0.05255InformativeInherited
Phenotypic Abnormality (PA)Absent hand0.000196Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the humerus0.0006954Highly InformativeDirect
Phenotypic Abnormality (PA)Oral cleft0.008665Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palate0.04676Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging2.588e-06Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype3.914e-05Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0001108Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.000529Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.001248Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.003972Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.04005Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.05108Least InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype8.377e-09Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype6.339e-08Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte morphology1.609e-07Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology2.238e-07Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology1.928e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell physiology4.656e-06Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype8.41e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis9.611e-06Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0.0004392Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.0007116Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.0008852Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.001427Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.00319Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.003207Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.00362Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.004671Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.01244Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.02623Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.03258Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.08102Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.1024Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1526Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.1884Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.724Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology4.764e-10InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin level1.639e-08InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection1.621e-06InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology1.972e-06InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology4.131e-06InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.0001574InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.0001899InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0002676InformativeDirect
Mammalian Phenotype (MP)abnormal cranium morphology0.0003092InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0004603InformativeDirect
Mammalian Phenotype (MP)abnormal cartilage morphology0.005632InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.02025InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.02202InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.02719InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.02929InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.04349InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.07297InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.07663InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1633InformativeInherited
Mammalian Phenotype (MP)abnormal facial morphology0.1716InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.205InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.2919InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.4322InformativeInherited
Mammalian Phenotype (MP)abnormal induced cell death0.452InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.4977InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.6634InformativeInherited
Mammalian Phenotype (MP)embryonic lethality0.6672InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8864InformativeInherited
Mammalian Phenotype (MP)abnormal CD4-positive T cell morphology7.912e-08Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation1.099e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal erythrocyte morphology1.553e-05Highly InformativeDirect
Mammalian Phenotype (MP)respiratory system inflammation4.713e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development4.836e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal dendritic cell number6.152e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development7.07e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.0001019Highly InformativeDirect
Mammalian Phenotype (MP)abnormal stomach epithelium morphology0.0001592Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.0001774Highly InformativeDirect
Mammalian Phenotype (MP)cleft palate0.0001881Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.0002034Highly InformativeDirect
Mammalian Phenotype (MP)complete lethality throughout fetal growth and development0.000211Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.0002177Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.0002402Highly InformativeDirect
Mammalian Phenotype (MP)no abnormal phenotype detected0.0003306Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.0003795Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0003886Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0005109Highly InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte number0.0005761Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.0006097Highly InformativeDirect
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0009909Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord morphology0.004752Highly InformativeInherited
Mammalian Phenotype (MP)increased leukemia incidence0.005675Highly InformativeInherited
Mammalian Phenotype (MP)abnormal clavicle morphology0.02139Highly InformativeInherited
Mammalian Phenotype (MP)embryonic lethality during organogenesis0.0376Highly InformativeInherited
Mammalian Phenotype (MP)decreased sensitivity to induced cell death0.064Highly InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch size0.1155Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.148Highly InformativeInherited
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.2219Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.8848Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.791Least InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.0007835Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased cell number0.0008264Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.01227Least InformativeInherited
Fly Anatomy (FA)cell0.01982Least InformativeInherited
Fly Anatomy (FA)larva0.04729Least InformativeInherited
Fly Anatomy (FA)organ system0.1051Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)sense organ0.007277Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.2334Moderately InformativeInherited
Fly Anatomy (FA)mechanosensory sensory organ0.000844InformativeDirect
Fly Anatomy (FA)circulatory system0.001284InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001142Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval circulatory system0.0003369Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.1435Least InformativeInherited
Zebrafish Anatomy (ZA)embryonic structure0.0007759Moderately InformativeDirect
Zebrafish Anatomy (ZA)paraxial mesoderm1.864e-05InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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