SUPERFAMILY 1.75 HMM library and genome assignments server


p53-like transcription factors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Families:   p53 DNA-binding domain-like [ 81314] (2)
  Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
  T-box [ 81316] (2)
  STAT DNA-binding domain [ 81317] (3)
  RUNT domain [ 81318]
  DNA-binding domain from NDT80 [ 81992]
  DNA-binding protein LAG-1 (CSL) [ 110080]


Superfamily statistics
Genomes (354) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,850 7,648 53
Proteins 5,743 7,570 53


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0000000000052830Least InformativeDirect
Biological Process (BP)developmental process0.000000000023360Least InformativeDirect
Biological Process (BP)regulation of cellular process0.00000000050520.000000000006692Least InformativeDirect
Biological Process (BP)response to stimulus0.00047570Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.0021570Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0065180.000000000000005546Least InformativeInherited
Biological Process (BP)biosynthetic process0.089290.000000004601Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.063940Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.10280.0000000001572Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.065430Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.13740.0000000000007995Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.088710Least InformativeInherited
Biological Process (BP)immune system process0.00070140Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.0002670.000000001554Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process0.00044430Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.000049780Moderately InformativeDirect
Biological Process (BP)RNA metabolic process0.00097590Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.000000000000043820Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00000000000037470Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00000052070Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.0000092450Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0007230Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.000080250Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.019650.0001804Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.0025340Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0017970Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0023130Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.0040770Moderately InformativeInherited
Biological Process (BP)organ development0.0010380Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.034830.05474Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.027720Moderately InformativeInherited
Biological Process (BP)gene expression0.002360Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.0017730Moderately InformativeInherited
Biological Process (BP)tissue development0.0011490.00000000000004075Moderately InformativeInherited
Biological Process (BP)transcription, DNA-dependent0.0000055410InformativeDirect
Biological Process (BP)organ morphogenesis0.000045180.000000000002154InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.00021980InformativeDirect
Biological Process (BP)positive regulation of gene expression0.00011410InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.00037040InformativeDirect
Biological Process (BP)regulation of apoptotic process0.00000094270.0001581InformativeDirect
Biological Process (BP)embryonic organ development0.00017040InformativeDirect
Biological Process (BP)embryonic morphogenesis0.00013580InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process0.000004970InformativeDirect
Biological Process (BP)muscle structure development0.0023990.00001475InformativeInherited
Biological Process (BP)leukocyte activation0.002560.000002752InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.013520InformativeInherited
Biological Process (BP)cardiovascular system development0.0090930.00000000000001761InformativeInherited
Biological Process (BP)hair follicle development0.000000010060.00000000000001761Highly InformativeDirect
Biological Process (BP)pattern specification process0.000083550Highly InformativeDirect
Biological Process (BP)cell fate commitment0.000021650.00000000000001422Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent0.00011120Highly InformativeDirect
Biological Process (BP)stem cell development0.00029990.0000000000007231Highly InformativeDirect
Molecular Function (MF)binding0.000011330Least InformativeDirect
Molecular Function (MF)nucleic acid binding0.00000000000010060Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding00InformativeDirect
Molecular Function (MF)chromatin binding0.000000002170InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.00000011830Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0000000000007995 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000000004601 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000000001572 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000000000005546 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.000000000006692 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.07614 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.6247 Least Informative Inherited
Biological Process (BP) reproduction 0.000000005262 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0001972 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000001554 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.000000008637 Moderately Informative Direct
Biological Process (BP) tissue development 0.00000000000004075 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0001804 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000001291 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000000005451 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000001695 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000004598 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.007952 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.3246 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001739 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.05296 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.05474 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.009608 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.6128 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.006123 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8583 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0.0008522 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0 Informative Direct
Biological Process (BP) immune response 0.0000000009877 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.0000004677 Informative Direct
Biological Process (BP) mitochondrion organization 0.000002817 Informative Direct
Biological Process (BP) central nervous system development 0.0004447 Informative Direct
Biological Process (BP) organ morphogenesis 0.000000000002154 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0006084 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) lipid localization 0.0002437 Informative Direct
Biological Process (BP) programmed cell death 0 Informative Direct
Biological Process (BP) protein transport 0.0001859 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0003931 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) response to nutrient levels 0.00000000003153 Informative Direct
Biological Process (BP) protein localization to organelle 0.00006624 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) tube development 0.000000000002941 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00000000000002434 Informative Direct
Biological Process (BP) regulation of growth 0.0000000002742 Informative Direct
Biological Process (BP) locomotion 0.0002438 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0001581 Informative Direct
Biological Process (BP) leukocyte activation 0.000002752 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) embryonic organ development 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000000003541 Informative Direct
Biological Process (BP) tissue morphogenesis 0.00000000000002099 Informative Direct
Biological Process (BP) gland development 0.000000003385 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0001061 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.0000000002511 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000715 Informative Direct
Biological Process (BP) muscle structure development 0.00001475 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0001002 Informative Direct
Biological Process (BP) cardiovascular system development 0.00000000000001761 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0007718 Informative Direct
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 0.07113 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.06295 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.9 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1615 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.006527 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.007351 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.07961 Informative Inherited
Biological Process (BP) response to inorganic substance 0.8937 Informative Inherited
Biological Process (BP) metal ion transport 0.07627 Informative Inherited
Biological Process (BP) muscle tissue development 0.8179 Informative Inherited
Biological Process (BP) sensory organ development 0.3777 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.03318 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.7636 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.629 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.5095 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001344 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.2554 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) cellular membrane organization 0.2209 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.003306 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.003383 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.002332 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.4348 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01794 Informative Inherited
Biological Process (BP) single organism reproductive process 0.359 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.01331 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.06335 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.8164 Informative Inherited
Biological Process (BP) regulation of response to stress 0.2323 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) response to lipid 0.6727 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.07515 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.08366 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.3508 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.6257 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) response to other organism 0.9268 Informative Inherited
Biological Process (BP) response to light stimulus 0.1454 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.08664 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.469 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.01707 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) cell cycle process 0.2053 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) cellular component movement 0.7764 Informative Inherited
Biological Process (BP) localization of cell 0.003241 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) skeletal system development 0.00000002977 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000006571 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0005545 Highly Informative Direct
Biological Process (BP) hair follicle development 0.00000000000001761 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 0.000001459 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0003449 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0000003307 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.0000000001141 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) aging 0.000000000000003722 Highly Informative Direct
Biological Process (BP) lactation 0.0000002893 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0003048 Highly Informative Direct
Biological Process (BP) response to UV 0.0000000000004257 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.000000000004016 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.00000008192 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0.00000000000001077 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00000009816 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0 Highly Informative Direct
Biological Process (BP) protein import 0.000000007591 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.000004098 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.0000001183 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.0005579 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.000000008958 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.00000003921 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.0000000001434 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 0.000000003695 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.00000279 Highly Informative Direct
Biological Process (BP) endocrine system development 0.000707 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0.000009078 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.00000367 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.00000000007891 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.000000000005505 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.00002891 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.00000000000001422 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 0.0001502 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.0000004105 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.0000158 Highly Informative Direct
Biological Process (BP) stem cell development 0.0000000000007231 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 0.000352 Highly Informative Direct
Biological Process (BP) nuclear import 0.0000000001225 Highly Informative Direct
Biological Process (BP) interphase 0.000001126 Highly Informative Direct
Biological Process (BP) response to calcium ion 0.00002685 Highly Informative Direct
Biological Process (BP) mesenchyme development 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0003315 Highly Informative Direct
Biological Process (BP) cellular response to metal ion 0.000006185 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0.000000002643 Highly Informative Direct
Biological Process (BP) renal system development 0.000004058 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.00009392 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000004449 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0.000002064 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.000000000006174 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.00001075 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.0004432 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.0000000000847 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.000000000000003722 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.0008769 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 1 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.4611 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.01308 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.01072 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.01294 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.09357 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.01167 Highly Informative Inherited
Biological Process (BP) inner ear development 0.01151 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.7132 Highly Informative Inherited
Biological Process (BP) regulation of calcium-mediated signaling 0.02381 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 1 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.00768 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.5813 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.002028 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.5672 Highly Informative Inherited
Biological Process (BP) sensory perception 0.00116 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.001261 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.002008 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.37 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.8242 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.002009 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.1107 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.04849 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.379 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.08338 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.9435 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.4752 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.01764 Highly Informative Inherited
Biological Process (BP) regulation of cell killing 0.07644 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.7201 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.2977 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.1354 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 0.9056 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1636 Highly Informative Inherited
Biological Process (BP) activation of immune response 1 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.6068 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.0126 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.01066 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.006253 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.8786 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.01236 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.6183 Highly Informative Inherited
Biological Process (BP) positive regulation of epithelial cell proliferation 0.8725 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.02163 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) cell division 0.4821 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.3291 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.006559 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.006972 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.02523 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated immunity 0.4432 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.00569 Highly Informative Inherited
Biological Process (BP) B cell activation 0.8521 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.2991 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.006019 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.5222 Highly Informative Inherited
Biological Process (BP) ossification 0.3088 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.7886 Highly Informative Inherited
Biological Process (BP) gonad development 0.4223 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.00005789 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0028 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.4224 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.00001002 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.00000003306 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000001306 Informative Direct
Molecular Function (MF) transition metal ion binding 0.0001023 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00003449 Informative Direct
Molecular Function (MF) enzyme binding 0.09296 Informative Inherited
Molecular Function (MF) protein binding transcription factor activity 0.00000166 Highly Informative Direct
Molecular Function (MF) copper ion binding 0.000000000001045 Highly Informative Direct
Molecular Function (MF) ATP binding 0.00000000001045 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) kinase binding 0.008311 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0.000006293 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.3494 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.01277 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0008699 Informative Direct
Cellular Component (CC) nucleoplasm part 0.000002173 Informative Direct
Cellular Component (CC) extracellular matrix 0.136 Informative Inherited
Cellular Component (CC) transcription factor complex 0 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.01655 Highly Informative Inherited
Cellular Component (CC) extracellular matrix part 0.004617 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.08181Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.001495Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.01066Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.01789Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.02387Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.1205Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000003096InformativeDirect
Disease Ontology (DO)chronic leukemia0.0003627InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.0004888InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.0005847InformativeDirect
Disease Ontology (DO)physical disorder0.00102InformativeInherited
Disease Ontology (DO)renal carcinoma0.002079InformativeInherited
Disease Ontology (DO)lymphoma0.00738InformativeInherited
Disease Ontology (DO)colorectal cancer0.008019InformativeInherited
Disease Ontology (DO)esophageal disease0.008164InformativeInherited
Disease Ontology (DO)viral infectious disease0.2597InformativeInherited
Disease Ontology (DO)breast carcinoma0.2983InformativeInherited
Disease Ontology (DO)ulcerative colitis0.00000009497Highly InformativeDirect
Disease Ontology (DO)Burkitt's lymphoma0.00003258Highly InformativeDirect
Disease Ontology (DO)mumps0.00008781Highly InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0004663Highly InformativeDirect
Disease Ontology (DO)pertussis0.0005158Highly InformativeDirect
Disease Ontology (DO)hemangioma0.0006014Highly InformativeDirect
Disease Ontology (DO)stomach disease0.005467Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.1252Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.778Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.02111Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.1942Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.01602InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the hand0.05331InformativeInherited
Phenotypic Abnormality (PA)Absent hand0.0001998Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the humerus0.0008101Highly InformativeDirect
Phenotypic Abnormality (PA)Oral cleft0.008724Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palate0.04693Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.000002639Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0.00003998Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0001136Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0005228Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.001241Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.004096Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.04002Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.05198Least InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.000000008943Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00000006743Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.0000001486Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.0000002379Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.00000197Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell physiology0.00000514Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.000008855Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0.00001057Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0.0004346Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.0006874Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.000901Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.001438Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.003121Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.003242Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.00367Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.004675Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.01185Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.02661Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.03214Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.08061Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.1016Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1506Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.1888Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.582Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.7229Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.0000000004268InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin level0.00000001728InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.000001766InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.000002102InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.0001596InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0002718InformativeDirect
Mammalian Phenotype (MP)abnormal cranium morphology0.0003134InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0004561InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.002937InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.005691InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.01399InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.02052InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.02135InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.03011InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.04351InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.07467InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.08004InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.08853InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1639InformativeInherited
Mammalian Phenotype (MP)abnormal facial morphology0.1683InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.2061InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.2935InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3151InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.4337InformativeInherited
Mammalian Phenotype (MP)abnormal induced cell death0.4588InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.5InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.656InformativeInherited
Mammalian Phenotype (MP)embryonic lethality0.6649InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8862InformativeInherited
Mammalian Phenotype (MP)decreased B cell proliferation0.00001055Highly InformativeDirect
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.00001548Highly InformativeDirect
Mammalian Phenotype (MP)respiratory system inflammation0.00004543Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.00004965Highly InformativeDirect
Mammalian Phenotype (MP)abnormal dendritic cell number0.00006474Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.00007252Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.0001024Highly InformativeDirect
Mammalian Phenotype (MP)abnormal stomach epithelium morphology0.000162Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.0001803Highly InformativeDirect
Mammalian Phenotype (MP)cleft palate0.0001871Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.0002078Highly InformativeDirect
Mammalian Phenotype (MP)complete lethality throughout fetal growth and development0.0002171Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.0002213Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.0002442Highly InformativeDirect
Mammalian Phenotype (MP)no abnormal phenotype detected0.0003349Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0003941Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.00042Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0005188Highly InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte number0.0006043Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.0006176Highly InformativeDirect
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0009905Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord morphology0.004807Highly InformativeInherited
Mammalian Phenotype (MP)increased leukemia incidence0.005692Highly InformativeInherited
Mammalian Phenotype (MP)abnormal clavicle morphology0.02139Highly InformativeInherited
Mammalian Phenotype (MP)embryonic lethality during organogenesis0.03826Highly InformativeInherited
Mammalian Phenotype (MP)decreased sensitivity to induced cell death0.064Highly InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch size0.1155Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.1476Highly InformativeInherited
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.2169Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.8848Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.791Least InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.0007835Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased cell number0.0008601Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.01456Least InformativeInherited
Fly Anatomy (FA)larva0.04851Least InformativeInherited
Fly Anatomy (FA)cell0.09767Least InformativeInherited
Fly Anatomy (FA)organ system0.1094Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)late embryo0.2343Moderately InformativeInherited
Fly Anatomy (FA)mechanosensory system0.0006047InformativeDirect
Fly Anatomy (FA)circulatory system0.001135InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001027Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval circulatory system0.0002967Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.1419Least InformativeInherited
Zebrafish Anatomy (ZA)embryonic structure0.0007502Moderately InformativeDirect
Zebrafish Anatomy (ZA)paraxial mesoderm0.00001804InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.09253Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.4662Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7437Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.8745Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.001858Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.01897Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.0994Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.1846Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7577Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.000003217InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.000009553InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00002049InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0004197InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.0006555InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0008641InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.001315InformativeInherited
Xenopus ANatomical entity (XAN)primordium0.002884InformativeInherited
Xenopus ANatomical entity (XAN)heart0.355InformativeInherited
Xenopus ANatomical entity (XAN)involuted ventral mesoderm0.0000001698Highly InformativeDirect
Xenopus ANatomical entity (XAN)fused heart primordium0.000003635Highly InformativeDirect
Xenopus ANatomical entity (XAN)appendage0.00001193Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.00005014Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0000951Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0009909Highly InformativeDirect
Xenopus ANatomical entity (XAN)marginal zone0.6865Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0006959Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCell cycle0.000000000004799Moderately InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.000000001946Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.0001451Moderately InformativeDirect
DiseaseTumor suppressor0Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainANK repeat0.0000001169InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0.0000000004893Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0000000008195Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationMethylation0.000001718Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.00001155InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008967 SSF49417 Protein matches
Abstract

This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis [PubMed12826037]; NFATC regulates the production of effector proteins involved in coordinating the immune response [PubMed8990122]; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth [PubMed12729611]; STAT-1 plays an important role in B lymphocyte growth and function [PubMed12855573]; and NFkappaB is involved in the inflammatory response [PubMed12421671]. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex [PubMed11780147]. Protein interactions may also serve to stabilize the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PubMed9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the p53-like transcription factors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]