SUPERFAMILY 1.75 HMM library and genome assignments server

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p53-like transcription factors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Families:   p53 DNA-binding domain-like [ 81314] (2)
  Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
  T-box [ 81316] (2)
  STAT DNA-binding domain [ 81317] (3)
  RUNT domain [ 81318]
  DNA-binding domain from NDT80 [ 81992]
  DNA-binding protein LAG-1 (CSL) [ 110080]


Superfamily statistics
Genomes (359) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,139 7,648 53
Proteins 6,030 7,570 53


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0000000000067910Least InformativeDirect
Biological Process (BP)developmental process0.000000000030220Least InformativeDirect
Biological Process (BP)regulation of cellular process0.00000000071730.00000000000386Least InformativeDirect
Biological Process (BP)response to stimulus0.00060940Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.0020340Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0063680.000000000000003741Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.072170.00000000000004112Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.15160.0000000001874Least InformativeInherited
Biological Process (BP)biosynthetic process0.099680.0000004482Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.070930Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.098260.000000000000009109Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.10890.00000001456Least InformativeInherited
Biological Process (BP)immune system process0.00074610Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.00028750.000000001176Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.000050880Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00000000000006060Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00000000000052960Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00000050830Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.0000094180Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00063070Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.000073980Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.0180.000119Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.0029020Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0020360Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0027020Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.0046420Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.0010840Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.0044220Moderately InformativeInherited
Biological Process (BP)organ development0.0010770Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.034320.04192Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0024810Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.028840Moderately InformativeInherited
Biological Process (BP)gene expression0.0025810Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.0019120Moderately InformativeInherited
Biological Process (BP)tissue development0.0011990.000000000000075Moderately InformativeInherited
Biological Process (BP)transcription, DNA-dependent0.0000059290InformativeDirect
Biological Process (BP)organ morphogenesis0.00005050.000000000001931InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.00020670InformativeDirect
Biological Process (BP)positive regulation of gene expression0.00012350InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.00036980InformativeDirect
Biological Process (BP)regulation of apoptotic process0.0000011150.000155InformativeDirect
Biological Process (BP)embryonic organ development0.00017390InformativeDirect
Biological Process (BP)embryonic morphogenesis0.00013240InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process0.0000047410InformativeDirect
Biological Process (BP)embryo development ending in birth or egg hatching0.00000000017260.2067InformativeInherited
Biological Process (BP)muscle structure development0.0026750.00001938InformativeInherited
Biological Process (BP)leukocyte activation0.0025190.000002856InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.013710InformativeInherited
Biological Process (BP)cardiovascular system development0.0092520.00000000000002112InformativeInherited
Biological Process (BP)hair follicle development0.000000010550.00000000000002447Highly InformativeDirect
Biological Process (BP)pattern specification process0.000091540Highly InformativeDirect
Biological Process (BP)cell fate commitment0.000020440.00000000000001083Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent0.00010870Highly InformativeDirect
Biological Process (BP)stem cell development0.00028180.000000000001728Highly InformativeDirect
Molecular Function (MF)binding0.000016460Least InformativeDirect
Molecular Function (MF)nucleic acid binding0.00000000000014270Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding00InformativeDirect
Molecular Function (MF)chromatin binding0.0000000020770InformativeDirect
Molecular Function (MF)transcription regulatory region DNA binding0.000000013061Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00000014750Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.00000000000004112 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0000000001874 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0000004482 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000001456 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000000000003741 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00000000000386 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000000000000009109 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.6893 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.1055 Least Informative Inherited
Biological Process (BP) reproduction 0.00000002083 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0001577 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000001176 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00000004228 Moderately Informative Direct
Biological Process (BP) tissue development 0.000000000000075 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.000119 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000001918 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000000002521 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000104 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000004449 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.3956 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001148 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.04862 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.04192 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01325 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.6593 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.01677 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8444 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0.0003853 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) immune response 0.000000001322 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.0000002517 Informative Direct
Biological Process (BP) mitochondrion organization 0.0000001929 Informative Direct
Biological Process (BP) central nervous system development 0.0003613 Informative Direct
Biological Process (BP) organ morphogenesis 0.000000000001931 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0006042 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) lipid localization 0.0002426 Informative Direct
Biological Process (BP) protein transport 0.0002841 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0003087 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) response to nutrient levels 0.0000000001354 Informative Direct
Biological Process (BP) protein localization to organelle 0.00009035 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) tube development 0.000000000002481 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000000000007318 Informative Direct
Biological Process (BP) regulation of growth 0.0000000003238 Informative Direct
Biological Process (BP) locomotion 0.0004571 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000155 Informative Direct
Biological Process (BP) leukocyte activation 0.000002856 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) embryonic organ development 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000000006363 Informative Direct
Biological Process (BP) tissue morphogenesis 0.00000000000003449 Informative Direct
Biological Process (BP) gland development 0.000000002573 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0001323 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.0000000001727 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0005763 Informative Direct
Biological Process (BP) muscle structure development 0.00001938 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.00005072 Informative Direct
Biological Process (BP) cardiovascular system development 0.00000000000002112 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0004814 Informative Direct
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 0.06136 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.08088 Informative Inherited
Biological Process (BP) negative regulation of transport 0.8881 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.9928 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.9062 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.01758 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.007679 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.1068 Informative Inherited
Biological Process (BP) response to inorganic substance 0.9042 Informative Inherited
Biological Process (BP) muscle tissue development 0.8242 Informative Inherited
Biological Process (BP) sensory organ development 0.3712 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.03258 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.7964 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.613 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.5165 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001875 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.2067 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) cellular membrane organization 0.1579 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.002812 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.002654 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1321 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.003004 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.4338 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.4656 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.8462 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01745 Informative Inherited
Biological Process (BP) single organism reproductive process 0.371 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.01214 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.0608 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.8188 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) response to lipid 0.5815 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.08693 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.131 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.4006 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.6591 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) response to other organism 0.9242 Informative Inherited
Biological Process (BP) response to light stimulus 0.1465 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.08901 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.4914 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.009152 Informative Inherited
Biological Process (BP) cell cycle process 0.1479 Informative Inherited
Biological Process (BP) metal ion transport 0.09009 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) cellular component movement 0.7813 Informative Inherited
Biological Process (BP) localization of cell 0.004008 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) skeletal system development 0.00000003548 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000006764 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0006386 Highly Informative Direct
Biological Process (BP) hair follicle development 0.00000000000002447 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 0.000002172 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.000443 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.00000004925 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.00000000002822 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) lactation 0.0000003501 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000144 Highly Informative Direct
Biological Process (BP) response to UV 0.0000000000007316 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.000000000004421 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.00000006842 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0.000000000000007318 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.0000001484 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0 Highly Informative Direct
Biological Process (BP) protein import 0.00000001049 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 0.00001366 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.000004348 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.00000524 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.0000008348 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.0005256 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.00000001217 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.00000006554 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.000000000225 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 0.000000003443 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.000002523 Highly Informative Direct
Biological Process (BP) endocrine system development 0.00061 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0.000008133 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.000003559 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.00000000002685 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.000000000008413 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.00003314 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.00000000000001083 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.0000003472 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.00001655 Highly Informative Direct
Biological Process (BP) stem cell development 0.000000000001728 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 0.0003219 Highly Informative Direct
Biological Process (BP) nuclear import 0.000000000163 Highly Informative Direct
Biological Process (BP) response to calcium ion 0.00002624 Highly Informative Direct
Biological Process (BP) mesenchyme development 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0004127 Highly Informative Direct
Biological Process (BP) cellular response to metal ion 0.000006441 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0.000000002311 Highly Informative Direct
Biological Process (BP) renal system development 0.000004179 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.00007529 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000005593 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0.000003683 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.000000000009184 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.00001335 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.0003983 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.0000000001518 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0.01359 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 1 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.4347 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.01455 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.01215 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.01381 Highly Informative Inherited
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.4339 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.001055 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.08959 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.008583 Highly Informative Inherited
Biological Process (BP) ear development 0.05331 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.7241 Highly Informative Inherited
Biological Process (BP) regulation of calcium-mediated signaling 0.02501 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 1 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.007439 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.5594 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.00205 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.6288 Highly Informative Inherited
Biological Process (BP) cell cycle phase 0.001829 Highly Informative Inherited
Biological Process (BP) sensory perception 0.001435 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.002334 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.001764 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.795 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.3605 Highly Informative Inherited
Biological Process (BP) positive regulation of cell killing 0.2893 Highly Informative Inherited
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.007817 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.01056 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.001788 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.04434 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.4319 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.09218 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.8934 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.7927 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphorylation 0.2016 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.01527 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.4667 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.01505 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.6749 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.2815 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.1205 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1543 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.5941 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.01504 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.04364 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.8688 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.01521 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.7065 Highly Informative Inherited
Biological Process (BP) positive regulation of epithelial cell proliferation 0.8632 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.02639 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) cell division 0.4908 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.336 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.003458 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.008038 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.02399 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 1 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.4139 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated immunity 0.4324 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.006259 Highly Informative Inherited
Biological Process (BP) B cell activation 0.8662 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.3236 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.006644 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.5423 Highly Informative Inherited
Biological Process (BP) ossification 0.3143 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated cytotoxicity 0.4787 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.7642 Highly Informative Inherited
Biological Process (BP) gonad development 0.4381 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.0001406 Moderately Informative Direct
Molecular Function (MF) anion binding 0.004329 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.4629 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.00001645 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.00000005062 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000001996 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00003543 Informative Direct
Molecular Function (MF) enzyme binding 0.03108 Informative Inherited
Molecular Function (MF) protein binding transcription factor activity 0.0000026 Highly Informative Direct
Molecular Function (MF) copper ion binding 0.0000000000005701 Highly Informative Direct
Molecular Function (MF) ATP binding 0.00000000001756 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.000002487 Highly Informative Direct
Molecular Function (MF) kinase binding 0.03511 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0.00001924 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.4809 Least Informative Inherited
Cellular Component (CC) cytosol 0.00000000000001473 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.02421 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0006384 Informative Direct
Cellular Component (CC) nucleoplasm part 0.000001669 Informative Direct
Cellular Component (CC) extracellular matrix 0.1815 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.01887 Highly Informative Inherited
Cellular Component (CC) extracellular matrix part 0.006481 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.08282Least InformativeInherited
Disease Ontology (DO)musculoskeletal system cancer0.002592Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.0241Moderately InformativeInherited
Disease Ontology (DO)mouth disease0.04556Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.1193Moderately InformativeInherited
Disease Ontology (DO)leukemia0.1907Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000003383InformativeDirect
Disease Ontology (DO)chronic leukemia0.0003687InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.0005798InformativeDirect
Disease Ontology (DO)physical disorder0.001148InformativeInherited
Disease Ontology (DO)lymphoma0.007719InformativeInherited
Disease Ontology (DO)esophageal disease0.007969InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.01122InformativeInherited
Disease Ontology (DO)gastrointestinal system cancer0.04751InformativeInherited
Disease Ontology (DO)viral infectious disease0.2709InformativeInherited
Disease Ontology (DO)breast carcinoma0.2887InformativeInherited
Disease Ontology (DO)colitis0.0000001116Highly InformativeDirect
Disease Ontology (DO)Burkitt's lymphoma0.00003798Highly InformativeDirect
Disease Ontology (DO)mumps0.00008659Highly InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.000513Highly InformativeDirect
Disease Ontology (DO)pertussis0.0005391Highly InformativeDirect
Disease Ontology (DO)hemangioma0.0006138Highly InformativeDirect
Disease Ontology (DO)stomach disease0.006697Highly InformativeInherited
Disease Ontology (DO)colorectal cancer0.008999Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.1206Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7769Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.003585Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.0202Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.1876Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.01529InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the hand0.05441InformativeInherited
Phenotypic Abnormality (PA)Absent hand0.0001937Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the humerus0.0008039Highly InformativeDirect
Phenotypic Abnormality (PA)Oral cleft0.007855Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palate0.04279Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.000002589Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0.00003739Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0001105Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0001994Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.001272Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.004035Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.04002Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.05092Least InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.000000008419Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00000006223Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.0000001642Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.0000002068Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.000001895Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell physiology0.000004752Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.000008251Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0.000008608Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0.0004335Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.0007431Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.0009173Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.001418Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.003169Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.003311Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.003584Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.004627Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.008708Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.02562Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.0325Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.07428Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.08264Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.1021Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.1841Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.7239Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.0000000004728InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin level0.00000001853InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.000001717InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.000001887InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.0001536InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0002663InformativeDirect
Mammalian Phenotype (MP)abnormal cranium morphology0.0002963InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0006585InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.003095InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.005691InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.01383InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.02075InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.02205InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.03011InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.04273InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.0733InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.07626InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.0913InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1643InformativeInherited
Mammalian Phenotype (MP)abnormal facial morphology0.1746InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.2005InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.2878InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.2913InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.435InformativeInherited
Mammalian Phenotype (MP)abnormal induced cell death0.4771InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.5013InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.6589InformativeInherited
Mammalian Phenotype (MP)embryonic lethality0.7775InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8865InformativeInherited
Mammalian Phenotype (MP)decreased B cell proliferation0.00001079Highly InformativeDirect
Mammalian Phenotype (MP)complete lethality throughout fetal growth and development0.00003711Highly InformativeDirect
Mammalian Phenotype (MP)respiratory system inflammation0.00004957Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.00004985Highly InformativeDirect
Mammalian Phenotype (MP)abnormal dendritic cell number0.00006123Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.0000697Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.0001022Highly InformativeDirect
Mammalian Phenotype (MP)abnormal stomach epithelium morphology0.0001578Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.0001759Highly InformativeDirect
Mammalian Phenotype (MP)cleft palate0.0001851Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.0002008Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.0002154Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.0002383Highly InformativeDirect
Mammalian Phenotype (MP)no abnormal phenotype detected0.0003404Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.0003764Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0003865Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0005747Highly InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte number0.0005906Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.0006069Highly InformativeDirect
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0009739Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord morphology0.004677Highly InformativeInherited
Mammalian Phenotype (MP)increased leukemia incidence0.005507Highly InformativeInherited
Mammalian Phenotype (MP)abnormal head movements0.01319Highly InformativeInherited
Mammalian Phenotype (MP)abnormal clavicle morphology0.02144Highly InformativeInherited
Mammalian Phenotype (MP)embryonic lethality during organogenesis0.03787Highly InformativeInherited
Mammalian Phenotype (MP)decreased sensitivity to induced cell death0.06399Highly InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch size0.1156Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.1479Highly InformativeInherited
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.2224Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.8853Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.791Least InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.0007835Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased cell number0.0007954Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.01159Least InformativeInherited
Fly Anatomy (FA)cell0.01896Least InformativeInherited
Fly Anatomy (FA)larva0.04748Least InformativeInherited
Fly Anatomy (FA)organ system0.1031Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)late embryo0.2289Moderately InformativeInherited
Fly Anatomy (FA)mechanosensory sensory organ0.0008328InformativeDirect
Fly Anatomy (FA)circulatory system0.001245InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001158Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval circulatory system0.0003326Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.1456Least InformativeInherited
Zebrafish Anatomy (ZA)embryonic structure0.0008007Moderately InformativeDirect
Zebrafish Anatomy (ZA)paraxial mesoderm0.00001839InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.09366Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.4674Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7436Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.8746Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.002032Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.01985Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.1844Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7616Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.000004026InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00001084InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00002239InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0004572InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0009842InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.001486InformativeInherited
Xenopus ANatomical entity (XAN)primordium0.002996InformativeInherited
Xenopus ANatomical entity (XAN)heart0.355InformativeInherited
Xenopus ANatomical entity (XAN)involuted ventral mesoderm0.000000186Highly InformativeDirect
Xenopus ANatomical entity (XAN)fused heart primordium0.000003603Highly InformativeDirect
Xenopus ANatomical entity (XAN)appendage0.00001192Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.00005001Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.00009916Highly InformativeDirect
Xenopus ANatomical entity (XAN)marginal zone0.6723Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0006981Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCell cycle0.000000000004685Moderately InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.000000001911Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.0001492Moderately InformativeDirect
DiseaseTumor suppressor0Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainANK repeat0.0000001153InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0.0000000004933Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0000000009753Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationMethylation0.000001645Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.00001158InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008967 SSF49417 Protein matches
Abstract

This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis [PubMed12826037]; NFATC regulates the production of effector proteins involved in coordinating the immune response [PubMed8990122]; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth [PubMed12729611]; STAT-1 plays an important role in B lymphocyte growth and function [PubMed12855573]; and NFkappaB is involved in the inflammatory response [PubMed12421671]. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex [PubMed11780147]. Protein interactions may also serve to stabilize the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PubMed9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the p53-like transcription factors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]