SUPERFAMILY 1.75 HMM library and genome assignments server


Cu,Zn superoxide dismutase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Cu,Zn superoxide dismutase-like [ 49329]
Families:   Cu,Zn superoxide dismutase-like [ 49330] (2)


Superfamily statistics
Genomes (1,109) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,774 6,073 50
Proteins 2,551 5,858 50


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus1.628e-142.865e-13Least InformativeDirect
Biological Process (BP)developmental process8.555e-130.0002839Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.11560.4574Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.084520.4091Least InformativeInherited
Biological Process (BP)biosynthetic process0.0048820.02295Least InformativeInherited
Biological Process (BP)regulation of cellular process0.34561Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis4.351e-060.09221Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.35690.1774Least InformativeInherited
Biological Process (BP)regulation of metabolic process4.985e-050.001554Least InformativeInherited
Biological Process (BP)multicellular organismal process3.092e-100.003414Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0035670.1101Least InformativeInherited
Biological Process (BP)protein metabolic process4.818e-060.01714Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.11671Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0001490.05101Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.093940.4626Least InformativeInherited
Biological Process (BP)reproduction6.09e-151.15e-07Moderately InformativeDirect
Biological Process (BP)multi-organism process9.05e-155.43e-12Moderately InformativeDirect
Biological Process (BP)cellular amino acid metabolic process4.347e-112.183e-09Moderately InformativeDirect
Biological Process (BP)immune system process6.451e-113.215e-06Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus1.216e-097.643e-10Moderately InformativeDirect
Biological Process (BP)cellular protein modification process3.117e-090.000315Moderately InformativeDirect
Biological Process (BP)regulation of molecular function6.311e-091.535e-07Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound9.202e-092.685e-10Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process3.045e-083.383e-06Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus6.346e-089.234e-08Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process7.616e-080.0001561Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process1.032e-070.0002116Moderately InformativeDirect
Biological Process (BP)cellular response to stress1.288e-076.097e-05Moderately InformativeDirect
Biological Process (BP)regulation of cell communication1.934e-073.3e-05Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process2.205e-074.275e-05Moderately InformativeDirect
Biological Process (BP)regulation of signaling3.546e-070.0001552Moderately InformativeDirect
Biological Process (BP)system process8.569e-064.452e-05Moderately InformativeDirect
Biological Process (BP)tissue development1.222e-050.0002741Moderately InformativeDirect
Biological Process (BP)nervous system development1.356e-050.0005566Moderately InformativeDirect
Biological Process (BP)homeostatic process1.502e-050.0001354Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process2.802e-051.897e-05Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.0003170.006279Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.00034710.3687Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.019920.2933Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus6.283e-050.002559Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00011870.008592Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process1.777e-060.00268Moderately InformativeInherited
Biological Process (BP)response to organic substance0.05140.4748Moderately InformativeInherited
Biological Process (BP)organelle organization5.16e-050.01271Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process7.637e-060.08518Moderately InformativeInherited
Biological Process (BP)cell differentiation8.233e-100.005919Moderately InformativeInherited
Biological Process (BP)organ development0.0061920.01186Moderately InformativeInherited
Biological Process (BP)single-organism developmental process1.54e-080.00208Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0011610.0005152Moderately InformativeInherited
Biological Process (BP)muscle system process00InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process00InformativeDirect
Biological Process (BP)cellular amide metabolic process00InformativeDirect
Biological Process (BP)multicellular organismal homeostasis00InformativeDirect
Biological Process (BP)response to oxidative stress00InformativeDirect
Biological Process (BP)cellular component disassembly04.008e-15InformativeDirect
Biological Process (BP)regulation of kinase activity01.792e-13InformativeDirect
Biological Process (BP)reproductive system development05.072e-13InformativeDirect
Biological Process (BP)regulation of protein phosphorylation07.698e-12InformativeDirect
Biological Process (BP)single-organism behavior08.374e-12InformativeDirect
Biological Process (BP)negative regulation of cell death04.076e-11InformativeDirect
Biological Process (BP)apoptotic process04.541e-11InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade01.537e-10InformativeDirect
Biological Process (BP)positive regulation of signal transduction04.789e-10InformativeDirect
Biological Process (BP)protein phosphorylation04.59e-09InformativeDirect
Biological Process (BP)epithelium development02.386e-08InformativeDirect
Biological Process (BP)generation of neurons3.099e-151.197e-06InformativeDirect
Biological Process (BP)cytoskeleton organization1.483e-142.026e-08InformativeDirect
Biological Process (BP)regulation of lipid metabolic process3.176e-140InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process4.153e-142.219e-12InformativeDirect
Biological Process (BP)regulation of apoptotic process1.161e-131.724e-08InformativeDirect
Biological Process (BP)response to inorganic substance1.516e-130InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process4.513e-131.616e-09InformativeDirect
Biological Process (BP)cell projection organization1.326e-125.536e-07InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process1.381e-123.605e-10InformativeDirect
Biological Process (BP)embryonic organ development1.625e-125.012e-10InformativeDirect
Biological Process (BP)cellular membrane organization6.455e-127.56e-10InformativeDirect
Biological Process (BP)regulation of growth1.137e-111.24e-09InformativeDirect
Biological Process (BP)single organism reproductive process4.356e-111.013e-06InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound1.121e-101.965e-10InformativeDirect
Biological Process (BP)DNA metabolic process1.642e-101.593e-07InformativeDirect
Biological Process (BP)regulation of cytokine production7.491e-109.844e-12InformativeDirect
Biological Process (BP)embryonic morphogenesis1.131e-091.395e-06InformativeDirect
Biological Process (BP)sensory organ development2.406e-099.83e-07InformativeDirect
Biological Process (BP)anatomical structure homeostasis2.502e-097.66e-07InformativeDirect
Biological Process (BP)regulation of anatomical structure size3.261e-093.656e-07InformativeDirect
Biological Process (BP)regulation of system process5.118e-093.78e-09InformativeDirect
Biological Process (BP)cellular component morphogenesis1.15e-088.398e-06InformativeDirect
Biological Process (BP)positive regulation of phosphorus metabolic process1.635e-081.707e-09InformativeDirect
Biological Process (BP)positive regulation of protein metabolic process3.523e-077.564e-08InformativeDirect
Biological Process (BP)developmental process involved in reproduction3.865e-078.207e-07InformativeDirect
Biological Process (BP)negative regulation of biosynthetic process4.025e-072.645e-05InformativeDirect
Biological Process (BP)organ morphogenesis6.851e-070.000384InformativeDirect
Biological Process (BP)multi-organism reproductive process9.506e-077.383e-08InformativeDirect
Biological Process (BP)response to light stimulus7.187e-061.468e-05InformativeDirect
Biological Process (BP)multicellular organismal reproductive process8.84e-060.0003655InformativeDirect
Biological Process (BP)positive regulation of catalytic activity6.895e-050.0003033InformativeDirect
Biological Process (BP)response to wounding0.0001020.0153InformativeInherited
Biological Process (BP)blood circulation10InformativeInherited
Biological Process (BP)sexual reproduction0.0002030.001884InformativeInherited
Biological Process (BP)cellular cation homeostasis0.0041920.0001215InformativeInherited
Biological Process (BP)metal ion homeostasis0.019130.3325InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.067670.3427InformativeInherited
Biological Process (BP)locomotory behavior00Highly InformativeDirect
Biological Process (BP)epithelial cell development00Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process00Highly InformativeDirect
Biological Process (BP)response to superoxide00Highly InformativeDirect
Biological Process (BP)regulation of muscle contraction00Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)embryonic organ morphogenesis00Highly InformativeDirect
Biological Process (BP)negative regulation of neuron death00Highly InformativeDirect
Biological Process (BP)cellular iron ion homeostasis00Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production00Highly InformativeDirect
Biological Process (BP)response to axon injury00Highly InformativeDirect
Biological Process (BP)regulation of MAP kinase activity00Highly InformativeDirect
Biological Process (BP)positive regulation of protein serine/threonine kinase activity00Highly InformativeDirect
Biological Process (BP)multi-multicellular organism process00Highly InformativeDirect
Biological Process (BP)cellular component disassembly involved in execution phase of apoptosis00Highly InformativeDirect
Biological Process (BP)plasma membrane organization00Highly InformativeDirect
Biological Process (BP)ovulation cycle process00Highly InformativeDirect
Biological Process (BP)DNA catabolic process00Highly InformativeDirect
Biological Process (BP)glutathione metabolic process00Highly InformativeDirect
Biological Process (BP)heart contraction00Highly InformativeDirect
Biological Process (BP)vascular process in circulatory system00Highly InformativeDirect
Biological Process (BP)development of primary female sexual characteristics00Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process00Highly InformativeDirect
Biological Process (BP)regulation of multicellular organism growth00Highly InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis00Highly InformativeDirect
Biological Process (BP)glial cell differentiation00Highly InformativeDirect
Biological Process (BP)activation of protein kinase activity00Highly InformativeDirect
Biological Process (BP)aging00Highly InformativeDirect
Biological Process (BP)response to ethanol00Highly InformativeDirect
Biological Process (BP)positive regulation of MAPK cascade04.008e-15Highly InformativeDirect
Biological Process (BP)spermatogenesis01.53e-14Highly InformativeDirect
Biological Process (BP)inner ear development08.846e-14Highly InformativeDirect
Biological Process (BP)sensory perception01.352e-13Highly InformativeDirect
Biological Process (BP)regulation of blood pressure01.218e-12Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic process08.431e-12Highly InformativeDirect
Biological Process (BP)DNA repair01.795e-11Highly InformativeDirect
Biological Process (BP)gonad development1.34e-145.43e-14Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species1.767e-140Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process3.456e-149.696e-14Highly InformativeDirect
Biological Process (BP)epidermis development7.316e-146.897e-13Highly InformativeDirect
Biological Process (BP)response to heat2.095e-101.06e-07Highly InformativeDirect
Biological Process (BP)superoxide metabolic process2.857e-091.006e-11Highly InformativeDirect
Biological Process (BP)response to drug2.868e-082.035e-06Highly InformativeDirect
Biological Process (BP)response to UV3.273e-087.128e-09Highly InformativeDirect
Biological Process (BP)regulation of membrane potential9.744e-070.00065Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide0.00012880.0003579Highly InformativeDirect
Biological Process (BP)hydrogen peroxide metabolic process0.44480.632Highly InformativeInherited
Molecular Function (MF)binding6.93e-060.0005315Least InformativeDirect
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)cation binding1.314e-150Moderately InformativeDirect
Molecular Function (MF)protein binding0.00012410.1398Moderately InformativeInherited
Molecular Function (MF)transition metal ion binding05.227e-06InformativeDirect
Molecular Function (MF)enzyme binding6.237e-144.106e-10InformativeDirect
Molecular Function (MF)copper ion binding00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part3.075e-070.0006487Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle6.881e-060.0007288Least InformativeDirect
Cellular Component (CC)extracellular region3.16e-130Moderately InformativeDirect
Cellular Component (CC)vesicle4.032e-122.025e-09Moderately InformativeDirect
Cellular Component (CC)cell projection1.691e-111.939e-06Moderately InformativeDirect
Cellular Component (CC)cytosol1.685e-082.502e-09Moderately InformativeDirect
Cellular Component (CC)extracellular matrix00InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)cell projection part01.037e-10InformativeDirect
Cellular Component (CC)neuron part1.305e-157.457e-09InformativeDirect
Cellular Component (CC)dendrite03.129e-15Highly InformativeDirect
Cellular Component (CC)cell body03.199e-14Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 2.865e-13 Least Informative Direct
Biological Process (BP) developmental process 0.0002839 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.4574 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.4091 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.02295 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.09221 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.1774 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.001554 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.003414 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1101 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.01714 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.05101 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.4626 Least Informative Inherited
Biological Process (BP) reproduction 1.15e-07 Moderately Informative Direct
Biological Process (BP) multi-organism process 5.43e-12 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 2.183e-09 Moderately Informative Direct
Biological Process (BP) immune system process 3.215e-06 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 7.643e-10 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000315 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 1.535e-07 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 2.685e-10 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 3.383e-06 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 9.234e-08 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0001561 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0002116 Moderately Informative Direct
Biological Process (BP) cellular response to stress 6.097e-05 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 3.3e-05 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 4.275e-05 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0001552 Moderately Informative Direct
Biological Process (BP) system process 4.452e-05 Moderately Informative Direct
Biological Process (BP) tissue development 0.0002741 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0005566 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.0001354 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.897e-05 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0005152 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.006279 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.3687 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2933 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.002559 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.008592 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.00268 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4748 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.01271 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.08518 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.005919 Moderately Informative Inherited
Biological Process (BP) organ development 0.01186 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.00208 Moderately Informative Inherited
Biological Process (BP) muscle system process 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0 Informative Direct
Biological Process (BP) response to oxidative stress 0 Informative Direct
Biological Process (BP) cellular component disassembly 4.008e-15 Informative Direct
Biological Process (BP) regulation of kinase activity 1.792e-13 Informative Direct
Biological Process (BP) reproductive system development 5.072e-13 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 7.698e-12 Informative Direct
Biological Process (BP) single-organism behavior 8.374e-12 Informative Direct
Biological Process (BP) negative regulation of cell death 4.076e-11 Informative Direct
Biological Process (BP) apoptotic process 4.541e-11 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 1.537e-10 Informative Direct
Biological Process (BP) positive regulation of signal transduction 4.789e-10 Informative Direct
Biological Process (BP) protein phosphorylation 4.59e-09 Informative Direct
Biological Process (BP) epithelium development 2.386e-08 Informative Direct
Biological Process (BP) generation of neurons 1.197e-06 Informative Direct
Biological Process (BP) cytoskeleton organization 2.026e-08 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 2.219e-12 Informative Direct
Biological Process (BP) regulation of apoptotic process 1.724e-08 Informative Direct
Biological Process (BP) response to inorganic substance 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 1.616e-09 Informative Direct
Biological Process (BP) cell projection organization 5.536e-07 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 3.605e-10 Informative Direct
Biological Process (BP) embryonic organ development 5.012e-10 Informative Direct
Biological Process (BP) cellular membrane organization 7.56e-10 Informative Direct
Biological Process (BP) regulation of growth 1.24e-09 Informative Direct
Biological Process (BP) single organism reproductive process 1.013e-06 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 1.965e-10 Informative Direct
Biological Process (BP) DNA metabolic process 1.593e-07 Informative Direct
Biological Process (BP) regulation of cytokine production 9.844e-12 Informative Direct
Biological Process (BP) embryonic morphogenesis 1.395e-06 Informative Direct
Biological Process (BP) sensory organ development 9.83e-07 Informative Direct
Biological Process (BP) anatomical structure homeostasis 7.66e-07 Informative Direct
Biological Process (BP) regulation of anatomical structure size 3.656e-07 Informative Direct
Biological Process (BP) regulation of system process 3.78e-09 Informative Direct
Biological Process (BP) cellular component morphogenesis 8.398e-06 Informative Direct
Biological Process (BP) positive regulation of phosphorus metabolic process 1.707e-09 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 7.564e-08 Informative Direct
Biological Process (BP) developmental process involved in reproduction 8.207e-07 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 2.645e-05 Informative Direct
Biological Process (BP) organ morphogenesis 0.000384 Informative Direct
Biological Process (BP) multi-organism reproductive process 7.383e-08 Informative Direct
Biological Process (BP) response to light stimulus 1.468e-05 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0003655 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.0003033 Informative Direct
Biological Process (BP) cellular cation homeostasis 0.0001215 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) response to wounding 0.0153 Informative Inherited
Biological Process (BP) sexual reproduction 0.001884 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.3325 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.3427 Informative Inherited
Biological Process (BP) locomotory behavior 0 Highly Informative Direct
Biological Process (BP) epithelial cell development 0 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) response to superoxide 0 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0 Highly Informative Direct
Biological Process (BP) cellular iron ion homeostasis 0 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) response to axon injury 0 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly involved in execution phase of apoptosis 0 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) DNA catabolic process 0 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) heart contraction 0 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 0 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) response to ethanol 0 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 4.008e-15 Highly Informative Direct
Biological Process (BP) spermatogenesis 1.53e-14 Highly Informative Direct
Biological Process (BP) inner ear development 8.846e-14 Highly Informative Direct
Biological Process (BP) sensory perception 1.352e-13 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 1.218e-12 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 8.431e-12 Highly Informative Direct
Biological Process (BP) DNA repair 1.795e-11 Highly Informative Direct
Biological Process (BP) gonad development 5.43e-14 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 9.696e-14 Highly Informative Direct
Biological Process (BP) epidermis development 6.897e-13 Highly Informative Direct
Biological Process (BP) response to heat 1.06e-07 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 1.006e-11 Highly Informative Direct
Biological Process (BP) response to drug 2.035e-06 Highly Informative Direct
Biological Process (BP) response to UV 7.128e-09 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.00065 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0003579 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 0.632 Highly Informative Inherited
Molecular Function (MF) binding 0.0005315 Least Informative Direct
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.1398 Moderately Informative Inherited
Molecular Function (MF) transition metal ion binding 5.227e-06 Informative Direct
Molecular Function (MF) enzyme binding 4.106e-10 Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.0006487 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0007288 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) extracellular region 0 Moderately Informative Direct
Cellular Component (CC) vesicle 2.025e-09 Moderately Informative Direct
Cellular Component (CC) cell projection 1.939e-06 Moderately Informative Direct
Cellular Component (CC) cytosol 2.502e-09 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.01521 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.0505 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell projection part 1.037e-10 Informative Direct
Cellular Component (CC) neuron part 7.457e-09 Informative Direct
Cellular Component (CC) dendrite 3.129e-15 Highly Informative Direct
Cellular Component (CC) cell body 3.199e-14 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Superoxide dismutase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0Least InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)life span variant8.969e-05InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)male genitalia0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)pedicel0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)leaf lamina0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)stalk0Least InformativeDirect
Plant ANatomical entity (PAN)phyllome apex0Least InformativeDirect
Plant ANatomical entity (PAN)plant cell0.1423Least InformativeInherited
Plant ANatomical entity (PAN)guard cell0.0006465Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on superoxide as acceptor1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.0009976Least InformativeDirect
Cellular componentPeriplasm1.237e-14InformativeDirect
Cellular componentHost cytoplasm4.041e-09InformativeDirect
DomainSignal2.64e-09Least InformativeDirect
DomainTransit peptide0.0002845Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCopper0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationAntioxidant0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001424 SSF49329 Protein matches
Abstract

Superoxide dismutases are ubiquitous metalloproteins that prevent damage by oxygen-mediated free radicals by catalysing the dismutation of superoxide into molecular oxygen and hydrogen peroxide [PubMed2751312]. Superoxide is a normal by-product of aerobic respiration and is produced by a number of reactions, including oxidative phosphorylation and photosynthesis. The dismutase enzymes have a very high catalytic efficiency due to the attraction of superoxide to the ions bound at the active site [PubMed1463506, PubMed3891411].

There are three forms of superoxide dismutase, depending on the metal cofactor: Cu/Zn (which binds both copper and zinc), Fe and Mn types. The Fe and Mn forms are similar in their primary, secondary and tertiary structures, but are distinct from the Cu/Zn form [PubMed2263641]. Prokaryotes and protists contain Mn, Fe or both types, while most eukaryotic organisms utilise the Cu/Zn type.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cu,Zn superoxide dismutase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Cu,Zn superoxide dismutase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]