SUPERFAMILY 1.75 HMM library and genome assignments server

Cu,Zn superoxide dismutase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Cu,Zn superoxide dismutase-like [ 49329]
Families:   Cu,Zn superoxide dismutase-like [ 49330] (2)


Superfamily statistics
Genomes (1,366) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,156 10,448 50
Proteins 2,898 10,168 50


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.000017460.00004211Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.00013530.0002412Least InformativeDirect
Biological Process (BP)positive regulation of biological process0.00040680.0001482Least InformativeDirect
Biological Process (BP)biosynthetic process0.050260.1721Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.00096330.1144Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.42490.9615Least InformativeInherited
Biological Process (BP)regulation of cellular process0.42941Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.000016810.1584Least InformativeInherited
Biological Process (BP)developmental process0.000000000054230.001009Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.43640.9886Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0000000048990.005708Least InformativeInherited
Biological Process (BP)single-organism cellular process0.031720.4456Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.4680.9629Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.53961Least InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0000000000000016820Moderately InformativeDirect
Biological Process (BP)reproductive process0.0000000000000048440.00000004805Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.0000000000011790.00000000000002591Moderately InformativeDirect
Biological Process (BP)cellular response to stress0.0000000000033380.000000003224Moderately InformativeDirect
Biological Process (BP)multi-organism process0.0000000000084010.00000004457Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.000000000041370.000000007616Moderately InformativeDirect
Biological Process (BP)cellular amino acid metabolic process0.00000000023380.000000004002Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.00000000028090.00009698Moderately InformativeDirect
Biological Process (BP)immune system process0.00000000058110.00001188Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.000000013980.0005983Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.00000001450.0000000001074Moderately InformativeDirect
Biological Process (BP)sulfur compound metabolic process0.000000021010.000000007856Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.00000025640.00000002016Moderately InformativeDirect
Biological Process (BP)regulation of phosphorus metabolic process0.00000081610.0000005536Moderately InformativeDirect
Biological Process (BP)single-organism organelle organization0.0000011690.000661Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.000002250.0002472Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus0.0000056030.000004816Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.0000059410.000000000008403Moderately InformativeDirect
Biological Process (BP)nervous system development0.000015210.0006086Moderately InformativeDirect
Biological Process (BP)tissue development0.000017270.0003267Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00012810.00008134Moderately InformativeDirect
Biological Process (BP)response to organic substance0.76151Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.00006060.006467Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.017960.271Moderately InformativeInherited
Biological Process (BP)cell differentiation0.000000018530.016Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.000004470.002355Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.014410.01463Moderately InformativeInherited
Biological Process (BP)organ development0.0075240.0115Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.00000005790.002766Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.000031030.2375Moderately InformativeInherited
Biological Process (BP)multi-multicellular organism process00InformativeDirect
Biological Process (BP)blood circulation00InformativeDirect
Biological Process (BP)peptide metabolic process00InformativeDirect
Biological Process (BP)response to oxidative stress00InformativeDirect
Biological Process (BP)response to inorganic substance00InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process00InformativeDirect
Biological Process (BP)muscle system process00InformativeDirect
Biological Process (BP)cation homeostasis00InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis00.0000000000002061InformativeDirect
Biological Process (BP)regulation of protein phosphorylation00.00000000005891InformativeDirect
Biological Process (BP)multicellular organismal homeostasis0.0000000000000016820InformativeDirect
Biological Process (BP)positive regulation of intracellular signal transduction0.0000000000000016820.0000000001663InformativeDirect
Biological Process (BP)epithelium development0.0000000000000032510.0000002456InformativeDirect
Biological Process (BP)regulation of lipid metabolic process0.0000000000000063590InformativeDirect
Biological Process (BP)neurological system process0.0000000000000063590.0000000004171InformativeDirect
Biological Process (BP)apoptotic process0.000000000000018460.0000000002316InformativeDirect
Biological Process (BP)generation of neurons0.000000000000047780.000003586InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00000000000011980.000000000000005526InformativeDirect
Biological Process (BP)cytoskeleton organization0.00000000000011980.00000003872InformativeDirect
Biological Process (BP)DNA repair0.00000000000015810.0000000002232InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.00000000000059580.000000007561InformativeDirect
Biological Process (BP)regulation of apoptotic process0.00000000000065610.00000003445InformativeDirect
Biological Process (BP)embryonic organ development0.00000000000075360.000000000332InformativeDirect
Biological Process (BP)cellular component morphogenesis0.000000000001950.0000009223InformativeDirect
Biological Process (BP)regulation of growth0.0000000000027970.00000001917InformativeDirect
Biological Process (BP)cell projection organization0.0000000000042980.0000004949InformativeDirect
Biological Process (BP)single-organism membrane organization0.0000000000086390.0000000002851InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process0.000000000020360.00000001506InformativeDirect
Biological Process (BP)reproductive structure development0.000000000032530.00000000001575InformativeDirect
Biological Process (BP)embryonic morphogenesis0.000000000054980.0000000898InformativeDirect
Biological Process (BP)regulation of system process0.000000000079660.00000000001522InformativeDirect
Biological Process (BP)sensory organ development0.00000000029350.0000001049InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.00000000039470.00000001222InformativeDirect
Biological Process (BP)single organism reproductive process0.00000000051640.000002979InformativeDirect
Biological Process (BP)regulation of cytokine production0.0000000013260.00000000002618InformativeDirect
Biological Process (BP)anatomical structure homeostasis0.0000000033930.000001917InformativeDirect
Biological Process (BP)regulation of anatomical structure size0.000000005720.0000005346InformativeDirect
Biological Process (BP)negative regulation of cell death0.0000000076830.0000000003279InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.00000001820.0001287InformativeDirect
Biological Process (BP)negative regulation of biosynthetic process0.000000038730.00001765InformativeDirect
Biological Process (BP)organ morphogenesis0.000000072220.00005067InformativeDirect
Biological Process (BP)regulation of MAPK cascade0.00000030350.0000006256InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.00000041970.0000001235InformativeDirect
Biological Process (BP)multicellular organismal reproductive process0.0000067120.0002909InformativeDirect
Biological Process (BP)response to light stimulus0.000014180.00002066InformativeDirect
Biological Process (BP)cellular chemical homeostasis0.00029050.0002795InformativeDirect
Biological Process (BP)regulation of transferase activity00.02688InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.0084750.01079InformativeInherited
Biological Process (BP)sexual reproduction0.013830.1041InformativeInherited
Biological Process (BP)superoxide metabolic process00Highly InformativeDirect
Biological Process (BP)development of primary female sexual characteristics00Highly InformativeDirect
Biological Process (BP)glial cell differentiation00Highly InformativeDirect
Biological Process (BP)ensheathment of neurons00Highly InformativeDirect
Biological Process (BP)regulation of alcohol biosynthetic process00Highly InformativeDirect
Biological Process (BP)glutathione metabolic process00Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)vascular process in circulatory system00Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process00Highly InformativeDirect
Biological Process (BP)double-strand break repair00Highly InformativeDirect
Biological Process (BP)ovulation cycle process00Highly InformativeDirect
Biological Process (BP)cellular component disassembly00Highly InformativeDirect
Biological Process (BP)regulation of multicellular organism growth00Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species00Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production00Highly InformativeDirect
Biological Process (BP)aging00Highly InformativeDirect
Biological Process (BP)response to superoxide00Highly InformativeDirect
Biological Process (BP)regulation of muscle system process00Highly InformativeDirect
Biological Process (BP)negative regulation of neuron death00Highly InformativeDirect
Biological Process (BP)DNA catabolic process00Highly InformativeDirect
Biological Process (BP)response to axon injury00Highly InformativeDirect
Biological Process (BP)plasma membrane organization00Highly InformativeDirect
Biological Process (BP)heart contraction00Highly InformativeDirect
Biological Process (BP)transition metal ion homeostasis00Highly InformativeDirect
Biological Process (BP)execution phase of apoptosis00Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process00Highly InformativeDirect
Biological Process (BP)ear development00Highly InformativeDirect
Biological Process (BP)epidermis development00.000000000000003707Highly InformativeDirect
Biological Process (BP)embryonic organ morphogenesis00.000000000000003707Highly InformativeDirect
Biological Process (BP)locomotory behavior00.000000000000003707Highly InformativeDirect
Biological Process (BP)epithelial cell development00.000000000000003707Highly InformativeDirect
Biological Process (BP)gonad development00.000000000000007248Highly InformativeDirect
Biological Process (BP)positive regulation of MAPK cascade00.00000000000011Highly InformativeDirect
Biological Process (BP)spermatogenesis00.0000000000001485Highly InformativeDirect
Biological Process (BP)sensory perception00.0000000000003187Highly InformativeDirect
Biological Process (BP)cell morphogenesis involved in differentiation00.000000004436Highly InformativeDirect
Biological Process (BP)regulation of blood pressure0.0000000000000032510.000000000000521Highly InformativeDirect
Biological Process (BP)regulation of membrane potential0.0000000000000094410.00000000002173Highly InformativeDirect
Biological Process (BP)female pregnancy0.00000000045050.0000000000007483Highly InformativeDirect
Biological Process (BP)response to heat0.000000023380.000001046Highly InformativeDirect
Biological Process (BP)response to UV0.000000053370.000000008111Highly InformativeDirect
Biological Process (BP)response to drug0.0000015940.00005721Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase activity0.000027610.0001588Highly InformativeDirect
Biological Process (BP)response to alcohol0.000064070.0002842Highly InformativeDirect
Biological Process (BP)hydrogen peroxide metabolic process0.94211Highly InformativeInherited
Biological Process (BP)regulation of protein serine/threonine kinase activity0.0026290.001544Highly InformativeInherited
Molecular Function (MF)binding0.000021290.0007295Least InformativeDirect
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)cation binding0.000000000000043410Moderately InformativeDirect
Molecular Function (MF)enzyme binding0.0000000000010960.00000000247InformativeDirect
Molecular Function (MF)copper ion binding00Highly InformativeDirect
Molecular Function (MF)antioxidant activity00Highly InformativeDirect
Molecular Function (MF)protein phosphatase binding00Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0000045810.00001018Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.00020130.00000003069Least InformativeDirect
Cellular Component (CC)extracellular region part0.0000000000031450Moderately InformativeDirect
Cellular Component (CC)cell projection0.000000005750.00009201Moderately InformativeDirect
Cellular Component (CC)cytosol0.00000012230.000008894Moderately InformativeDirect
Cellular Component (CC)vesicle0.00000020570.00000395Moderately InformativeDirect
Cellular Component (CC)extracellular matrix00InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)neuron projection00.0000000006419InformativeDirect
Cellular Component (CC)dendrite00.00000000000000457Highly InformativeDirect
Cellular Component (CC)cell body00.000000000005891Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00004211 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0002412 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.0001482 Least Informative Direct
Biological Process (BP) biosynthetic process 0.1721 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1144 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.9615 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1584 Least Informative Inherited
Biological Process (BP) developmental process 0.001009 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.9886 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.005708 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4456 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.9629 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) reproductive process 0.00000004805 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00000000000002591 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.000000003224 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000004457 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000007616 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.000000004002 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00009698 Moderately Informative Direct
Biological Process (BP) immune system process 0.00001188 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0005983 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0000000001074 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.000000007856 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00000002016 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.0000005536 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.000661 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0002472 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000004816 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000000000008403 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0006086 Moderately Informative Direct
Biological Process (BP) tissue development 0.0003267 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00008134 Moderately Informative Direct
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.006467 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.271 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.016 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.002355 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01463 Moderately Informative Inherited
Biological Process (BP) organ development 0.0115 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.002766 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2375 Moderately Informative Inherited
Biological Process (BP) multi-multicellular organism process 0 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) response to oxidative stress 0 Informative Direct
Biological Process (BP) response to inorganic substance 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) muscle system process 0 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.0000000000002061 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.00000000005891 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0 Informative Direct
Biological Process (BP) positive regulation of intracellular signal transduction 0.0000000001663 Informative Direct
Biological Process (BP) epithelium development 0.0000002456 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0 Informative Direct
Biological Process (BP) neurological system process 0.0000000004171 Informative Direct
Biological Process (BP) apoptotic process 0.0000000002316 Informative Direct
Biological Process (BP) generation of neurons 0.000003586 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.000000000000005526 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000003872 Informative Direct
Biological Process (BP) DNA repair 0.0000000002232 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000000007561 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00000003445 Informative Direct
Biological Process (BP) embryonic organ development 0.000000000332 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000009223 Informative Direct
Biological Process (BP) regulation of growth 0.00000001917 Informative Direct
Biological Process (BP) cell projection organization 0.0000004949 Informative Direct
Biological Process (BP) single-organism membrane organization 0.0000000002851 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.00000001506 Informative Direct
Biological Process (BP) reproductive structure development 0.00000000001575 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0000000898 Informative Direct
Biological Process (BP) regulation of system process 0.00000000001522 Informative Direct
Biological Process (BP) sensory organ development 0.0000001049 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000001222 Informative Direct
Biological Process (BP) single organism reproductive process 0.000002979 Informative Direct
Biological Process (BP) regulation of cytokine production 0.00000000002618 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.000001917 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0000005346 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0000000003279 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0001287 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.00001765 Informative Direct
Biological Process (BP) organ morphogenesis 0.00005067 Informative Direct
Biological Process (BP) regulation of MAPK cascade 0.0000006256 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0000001235 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0002909 Informative Direct
Biological Process (BP) response to light stimulus 0.00002066 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0002795 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0007737 Informative Direct
Biological Process (BP) regulation of transferase activity 0.02688 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.01079 Informative Inherited
Biological Process (BP) sexual reproduction 0.1041 Informative Inherited
Biological Process (BP) superoxide metabolic process 0 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0 Highly Informative Direct
Biological Process (BP) ensheathment of neurons 0 Highly Informative Direct
Biological Process (BP) regulation of alcohol biosynthetic process 0 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) double-strand break repair 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) response to superoxide 0 Highly Informative Direct
Biological Process (BP) regulation of muscle system process 0 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0 Highly Informative Direct
Biological Process (BP) DNA catabolic process 0 Highly Informative Direct
Biological Process (BP) response to axon injury 0 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0 Highly Informative Direct
Biological Process (BP) heart contraction 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) execution phase of apoptosis 0 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0 Highly Informative Direct
Biological Process (BP) ear development 0 Highly Informative Direct
Biological Process (BP) epidermis development 0.000000000000003707 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.000000000000003707 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.000000000000003707 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.000000000000003707 Highly Informative Direct
Biological Process (BP) gonad development 0.000000000000007248 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.00000000000011 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0000000000001485 Highly Informative Direct
Biological Process (BP) sensory perception 0.0000000000003187 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000000004436 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.000000000000521 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.00000000002173 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0000000000007483 Highly Informative Direct
Biological Process (BP) response to heat 0.000001046 Highly Informative Direct
Biological Process (BP) response to UV 0.000000008111 Highly Informative Direct
Biological Process (BP) response to drug 0.00005721 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0001588 Highly Informative Direct
Biological Process (BP) response to alcohol 0.0002842 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.001544 Highly Informative Inherited
Molecular Function (MF) binding 0.0007295 Least Informative Direct
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.00001524 Moderately Informative Direct
Molecular Function (MF) enzyme binding 0.00000000247 Informative Direct
Molecular Function (MF) enzyme activator activity 0.000000008907 Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) antioxidant activity 0 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00001018 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000003069 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.7622 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00009201 Moderately Informative Direct
Cellular Component (CC) cytosol 0.000008894 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00000395 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.01631 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.02629 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) neuron projection 0.0000000006419 Informative Direct
Cellular Component (CC) microbody 0.00004694 Informative Direct
Cellular Component (CC) dendrite 0.00000000000000457 Highly Informative Direct
Cellular Component (CC) cell body 0.000000000005891 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Superoxide dismutase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0Least InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)life span variant0.00008969InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on superoxide as acceptor1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentPlastid0.02563Moderately InformativeInherited
Cellular componentPeriplasm0.00000000000001995InformativeDirect
Cellular componentHost cytoplasm0.0000000065InformativeDirect
Cellular componentChloroplast0.0003003InformativeDirect
DomainSignal0.0000000001783Least InformativeDirect
DomainTransit peptide0.00003015Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCopper0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationAntioxidant0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate0.0000003193Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001424 SSF49329 Protein matches
Abstract

Superoxide dismutases are ubiquitous metalloproteins that prevent damage by oxygen-mediated free radicals by catalysing the dismutation of superoxide into molecular oxygen and hydrogen peroxide [PubMed2751312]. Superoxide is a normal by-product of aerobic respiration and is produced by a number of reactions, including oxidative phosphorylation and photosynthesis. The dismutase enzymes have a very high catalytic efficiency due to the attraction of superoxide to the ions bound at the active site [PubMed1463506, PubMed3891411].

There are three forms of superoxide dismutase, depending on the metal cofactor: Cu/Zn (which binds both copper and zinc), Fe and Mn types. The Fe and Mn forms are similar in their primary, secondary and tertiary structures, but are distinct from the Cu/Zn form [PubMed2263641]. Prokaryotes and protists contain Mn, Fe or both types, while most eukaryotic organisms utilise the Cu/Zn type.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cu,Zn superoxide dismutase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Cu,Zn superoxide dismutase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]