SUPERFAMILY 1.75 HMM library and genome assignments server


Cu,Zn superoxide dismutase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Cu,Zn superoxide dismutase-like [ 49329]
Families:   Cu,Zn superoxide dismutase-like [ 49330] (2)


Superfamily statistics
Genomes (1,365) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,152 10,448 50
Proteins 2,897 10,168 50


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process8.359e-050.0001325Least InformativeDirect
Biological Process (BP)developmental process4.8e-110.0009742Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.45430.9617Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.40040.9579Least InformativeInherited
Biological Process (BP)single-organism cellular process2.367e-050.002858Least InformativeInherited
Biological Process (BP)biosynthetic process0.056140.1868Least InformativeInherited
Biological Process (BP)regulation of cellular process0.33571Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis1.452e-050.1338Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.66930.5874Least InformativeInherited
Biological Process (BP)multicellular organismal process7.533e-090.009457Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.56411Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.00080050.1063Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.41130.9847Least InformativeInherited
Biological Process (BP)reproduction7.062e-143.214e-07Moderately InformativeDirect
Biological Process (BP)immune system process5.902e-101.203e-05Moderately InformativeDirect
Biological Process (BP)system process1.039e-055.062e-05Moderately InformativeDirect
Biological Process (BP)cellular amino acid metabolic process2.819e-104.723e-09Moderately InformativeDirect
Biological Process (BP)sulfur compound metabolic process7.43e-091.221e-09Moderately InformativeDirect
Biological Process (BP)nervous system development1.133e-050.0005206Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus5.488e-064.53e-06Moderately InformativeDirect
Biological Process (BP)tissue development2.683e-050.0003191Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process2.552e-100.0001035Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction1.801e-108.535e-05Moderately InformativeDirect
Biological Process (BP)cellular response to stress3.153e-122.298e-09Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function3.258e-150Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus4.037e-071.184e-06Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity1.144e-051.679e-11Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process1.556e-052.249e-05Moderately InformativeDirect
Biological Process (BP)multi-organism process1.989e-135.522e-11Moderately InformativeDirect
Biological Process (BP)regulation of biological quality4.872e-119.116e-09Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus9.233e-132.112e-14Moderately InformativeDirect
Biological Process (BP)organic cyclic compound catabolic process1.252e-081.64e-07Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound1.076e-087.812e-11Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process2.975e-050.004323Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.017710.2701Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process1.304e-050.01006Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process11.005e-07Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process9.799e-080.0201Moderately InformativeInherited
Biological Process (BP)response to organic substance0.73271Moderately InformativeInherited
Biological Process (BP)organelle organization0.0021710.09492Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process1.307e-070.004759Moderately InformativeInherited
Biological Process (BP)cell differentiation1.564e-080.01458Moderately InformativeInherited
Biological Process (BP)organ development0.0084650.01319Moderately InformativeInherited
Biological Process (BP)single-organism developmental process7.045e-060.0381Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.014420.01541Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production6.449e-101.275e-11InformativeDirect
Biological Process (BP)regulation of protein phosphorylation04.468e-11InformativeDirect
Biological Process (BP)developmental process involved in reproduction5.819e-071.267e-06InformativeDirect
Biological Process (BP)muscle system process00InformativeDirect
Biological Process (BP)DNA metabolic process7.269e-133.536e-07InformativeDirect
Biological Process (BP)peptide metabolic process00InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process00InformativeDirect
Biological Process (BP)apoptotic process1.855e-142.339e-10InformativeDirect
Biological Process (BP)response to oxidative stress00InformativeDirect
Biological Process (BP)cytoskeleton organization1.204e-133.813e-08InformativeDirect
Biological Process (BP)sensory organ development2.314e-096.664e-07InformativeDirect
Biological Process (BP)blood circulation00InformativeDirect
Biological Process (BP)response to light stimulus1.439e-051.998e-05InformativeDirect
Biological Process (BP)organ morphogenesis5.427e-070.0002717InformativeDirect
Biological Process (BP)negative regulation of biosynthetic process2.403e-073.012e-05InformativeDirect
Biological Process (BP)positive regulation of signal transduction2.891e-141.094e-08InformativeDirect
Biological Process (BP)response to inorganic substance00InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade06.194e-10InformativeDirect
Biological Process (BP)cellular membrane organization6.384e-115.784e-10InformativeDirect
Biological Process (BP)regulation of lipid metabolic process3.333e-140InformativeDirect
Biological Process (BP)cell projection organization1.884e-101.395e-05InformativeDirect
Biological Process (BP)cellular component morphogenesis8.607e-098.351e-06InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process1.613e-111.521e-08InformativeDirect
Biological Process (BP)regulation of growth4.294e-122.45e-08InformativeDirect
Biological Process (BP)regulation of apoptotic process6.168e-133.241e-08InformativeDirect
Biological Process (BP)regulation of kinase activity07.232e-13InformativeDirect
Biological Process (BP)regulation of system process1.6e-084.07e-09InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process5.347e-136.79e-09InformativeDirect
Biological Process (BP)single organism reproductive process1.347e-099.903e-06InformativeDirect
Biological Process (BP)multi-multicellular organism process00InformativeDirect
Biological Process (BP)single-organism behavior05.032e-11InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process2.526e-053.943e-05InformativeDirect
Biological Process (BP)embryonic organ development6.412e-122.324e-09InformativeDirect
Biological Process (BP)embryonic morphogenesis7.586e-107.876e-07InformativeDirect
Biological Process (BP)multicellular organismal reproductive process2.14e-050.0006407InformativeDirect
Biological Process (BP)generation of neurons4.344e-143.38e-06InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process5.656e-138.128e-12InformativeDirect
Biological Process (BP)cation homeostasis00InformativeDirect
Biological Process (BP)cellular chemical homeostasis0.00046210.0003743InformativeDirect
Biological Process (BP)epithelium development6.381e-157.786e-08InformativeDirect
Biological Process (BP)negative regulation of cell death4.873e-096.618e-11InformativeDirect
Biological Process (BP)reproductive system development02.161e-12InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis02.214e-13InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound1.038e-133.741e-15InformativeDirect
Biological Process (BP)response to wounding0.00085040.04386InformativeInherited
Biological Process (BP)positive regulation of protein modification process0.0031270.0009902InformativeInherited
Biological Process (BP)sexual reproduction0.00031940.003062InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.41970.979InformativeInherited
Biological Process (BP)response to superoxide00Highly InformativeDirect
Biological Process (BP)cell morphogenesis involved in differentiation04.347e-09Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production00Highly InformativeDirect
Biological Process (BP)epithelial cell development01.931e-15Highly InformativeDirect
Biological Process (BP)vascular process in circulatory system00Highly InformativeDirect
Biological Process (BP)double-strand break repair00Highly InformativeDirect
Biological Process (BP)DNA catabolic process00Highly InformativeDirect
Biological Process (BP)glutathione metabolic process00Highly InformativeDirect
Biological Process (BP)superoxide metabolic process00Highly InformativeDirect
Biological Process (BP)regulation of muscle contraction00Highly InformativeDirect
Biological Process (BP)spermatogenesis01.331e-13Highly InformativeDirect
Biological Process (BP)female pregnancy0.00072617.83e-05Highly InformativeDirect
Biological Process (BP)aging00Highly InformativeDirect
Biological Process (BP)sensory perception03.144e-13Highly InformativeDirect
Biological Process (BP)locomotory behavior03.741e-15Highly InformativeDirect
Biological Process (BP)regulation of blood pressure3.258e-155.07e-13Highly InformativeDirect
Biological Process (BP)gonad development1.101e-145.088e-14Highly InformativeDirect
Biological Process (BP)response to heat2.347e-089.371e-07Highly InformativeDirect
Biological Process (BP)response to UV4.728e-086.814e-09Highly InformativeDirect
Biological Process (BP)epidermal cell differentiation00Highly InformativeDirect
Biological Process (BP)glial cell differentiation00Highly InformativeDirect
Biological Process (BP)cellular component disassembly06.543e-14Highly InformativeDirect
Biological Process (BP)ovulation cycle process00Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species00Highly InformativeDirect
Biological Process (BP)regulation of multicellular organism growth00Highly InformativeDirect
Biological Process (BP)regulation of membrane potential3.124e-131.358e-09Highly InformativeDirect
Biological Process (BP)response to drug2.962e-067.078e-05Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic process08.918e-12Highly InformativeDirect
Biological Process (BP)regulation of MAP kinase activity00Highly InformativeDirect
Biological Process (BP)positive regulation of MAPK cascade03.62e-14Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process00Highly InformativeDirect
Biological Process (BP)ear development00Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase activity2.935e-050.0001694Highly InformativeDirect
Biological Process (BP)development of primary female sexual characteristics00Highly InformativeDirect
Biological Process (BP)embryonic organ morphogenesis03.741e-15Highly InformativeDirect
Biological Process (BP)response to axon injury00Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process00Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process9.575e-142.426e-13Highly InformativeDirect
Biological Process (BP)transition metal ion homeostasis00Highly InformativeDirect
Biological Process (BP)heart contraction00Highly InformativeDirect
Biological Process (BP)execution phase of apoptosis00Highly InformativeDirect
Biological Process (BP)response to alcohol6.375e-050.0002697Highly InformativeDirect
Biological Process (BP)negative regulation of neuron death00Highly InformativeDirect
Biological Process (BP)hydrogen peroxide metabolic process0.93221Highly InformativeInherited
Molecular Function (MF)binding1.907e-050.0005983Least InformativeDirect
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)cation binding4.251e-140Moderately InformativeDirect
Molecular Function (MF)enzyme binding9.699e-132.214e-09InformativeDirect
Molecular Function (MF)copper ion binding00Highly InformativeDirect
Molecular Function (MF)antioxidant activity00Highly InformativeDirect
Molecular Function (MF)protein phosphatase binding00Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle7.069e-061.942e-05Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.00018698.762e-05Least InformativeDirect
Cellular Component (CC)cytosol1.165e-072.197e-07Moderately InformativeDirect
Cellular Component (CC)vesicle2.17e-073.69e-06Moderately InformativeDirect
Cellular Component (CC)cell projection7.573e-102.417e-05Moderately InformativeDirect
Cellular Component (CC)extracellular region part3.253e-120Moderately InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)extracellular matrix00InformativeDirect
Cellular Component (CC)neuron projection05.393e-10InformativeDirect
Cellular Component (CC)dendrite06.075e-15Highly InformativeDirect
Cellular Component (CC)cell body01.746e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.0001325 Least Informative Direct
Biological Process (BP) developmental process 0.0009742 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.9617 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.9579 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.002858 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.1868 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1338 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.5874 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.009457 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1063 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.9847 Least Informative Inherited
Biological Process (BP) reproduction 3.214e-07 Moderately Informative Direct
Biological Process (BP) immune system process 1.203e-05 Moderately Informative Direct
Biological Process (BP) system process 5.062e-05 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 4.723e-09 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 1.221e-09 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0005206 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 4.53e-06 Moderately Informative Direct
Biological Process (BP) tissue development 0.0003191 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0001035 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 8.535e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 1.005e-07 Moderately Informative Direct
Biological Process (BP) cellular response to stress 2.298e-09 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1.184e-06 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 1.679e-11 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 2.249e-05 Moderately Informative Direct
Biological Process (BP) multi-organism process 5.522e-11 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 9.116e-09 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 2.112e-14 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 1.64e-07 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 7.812e-11 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.004323 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2701 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01006 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.0201 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.09492 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.004759 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.01458 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.01319 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.0381 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01541 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 1.275e-11 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 4.468e-11 Informative Direct
Biological Process (BP) developmental process involved in reproduction 1.267e-06 Informative Direct
Biological Process (BP) muscle system process 0 Informative Direct
Biological Process (BP) DNA metabolic process 3.536e-07 Informative Direct
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) apoptotic process 2.339e-10 Informative Direct
Biological Process (BP) response to oxidative stress 0 Informative Direct
Biological Process (BP) cytoskeleton organization 3.813e-08 Informative Direct
Biological Process (BP) sensory organ development 6.664e-07 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) response to light stimulus 1.998e-05 Informative Direct
Biological Process (BP) organ morphogenesis 0.0002717 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 3.012e-05 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1.094e-08 Informative Direct
Biological Process (BP) response to inorganic substance 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0007645 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 6.194e-10 Informative Direct
Biological Process (BP) cellular membrane organization 5.784e-10 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0 Informative Direct
Biological Process (BP) cell projection organization 1.395e-05 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0.0009902 Informative Direct
Biological Process (BP) cellular component morphogenesis 8.351e-06 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 1.521e-08 Informative Direct
Biological Process (BP) regulation of growth 2.45e-08 Informative Direct
Biological Process (BP) regulation of apoptotic process 3.241e-08 Informative Direct
Biological Process (BP) regulation of kinase activity 7.232e-13 Informative Direct
Biological Process (BP) regulation of system process 4.07e-09 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 6.79e-09 Informative Direct
Biological Process (BP) single organism reproductive process 9.903e-06 Informative Direct
Biological Process (BP) multi-multicellular organism process 0 Informative Direct
Biological Process (BP) single-organism behavior 5.032e-11 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 3.943e-05 Informative Direct
Biological Process (BP) embryonic organ development 2.324e-09 Informative Direct
Biological Process (BP) embryonic morphogenesis 7.876e-07 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0006407 Informative Direct
Biological Process (BP) generation of neurons 3.38e-06 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 8.128e-12 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0003743 Informative Direct
Biological Process (BP) epithelium development 7.786e-08 Informative Direct
Biological Process (BP) negative regulation of cell death 6.618e-11 Informative Direct
Biological Process (BP) reproductive system development 2.161e-12 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 2.214e-13 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 3.741e-15 Informative Direct
Biological Process (BP) response to wounding 0.04386 Informative Inherited
Biological Process (BP) sexual reproduction 0.003062 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.979 Informative Inherited
Biological Process (BP) response to superoxide 0 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 4.347e-09 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) epithelial cell development 1.931e-15 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0 Highly Informative Direct
Biological Process (BP) double-strand break repair 0 Highly Informative Direct
Biological Process (BP) DNA catabolic process 0 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 1.331e-13 Highly Informative Direct
Biological Process (BP) female pregnancy 7.83e-05 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) sensory perception 3.144e-13 Highly Informative Direct
Biological Process (BP) locomotory behavior 3.741e-15 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 5.07e-13 Highly Informative Direct
Biological Process (BP) gonad development 5.088e-14 Highly Informative Direct
Biological Process (BP) response to heat 9.371e-07 Highly Informative Direct
Biological Process (BP) response to UV 6.814e-09 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 0 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 6.543e-14 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 1.358e-09 Highly Informative Direct
Biological Process (BP) response to drug 7.078e-05 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 8.918e-12 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 3.62e-14 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0 Highly Informative Direct
Biological Process (BP) ear development 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0001694 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 3.741e-15 Highly Informative Direct
Biological Process (BP) response to axon injury 0 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 2.426e-13 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) heart contraction 0 Highly Informative Direct
Biological Process (BP) execution phase of apoptosis 0 Highly Informative Direct
Biological Process (BP) response to alcohol 0.0002697 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Molecular Function (MF) binding 0.0005983 Least Informative Direct
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme binding 2.214e-09 Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) antioxidant activity 0 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1.942e-05 Least Informative Direct
Cellular Component (CC) cytoplasmic part 8.762e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytosol 2.197e-07 Moderately Informative Direct
Cellular Component (CC) vesicle 3.69e-06 Moderately Informative Direct
Cellular Component (CC) cell projection 2.417e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.02532 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.008661 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) microbody 4.267e-05 Informative Direct
Cellular Component (CC) neuron projection 5.393e-10 Informative Direct
Cellular Component (CC) dendrite 6.075e-15 Highly Informative Direct
Cellular Component (CC) cell body 1.746e-12 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Superoxide dismutase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0Least InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)life span variant8.969e-05InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on superoxide as acceptor1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentPlastid0.02545Moderately InformativeInherited
Cellular componentPeriplasm1.926e-14InformativeDirect
Cellular componentHost cytoplasm6.568e-09InformativeDirect
Cellular componentChloroplast0.0002969InformativeDirect
DomainSignal1.777e-10Least InformativeDirect
DomainTransit peptide2.953e-05Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCopper0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationAntioxidant0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate3.249e-07Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001424 SSF49329 Protein matches
Abstract

Superoxide dismutases are ubiquitous metalloproteins that prevent damage by oxygen-mediated free radicals by catalysing the dismutation of superoxide into molecular oxygen and hydrogen peroxide [PubMed2751312]. Superoxide is a normal by-product of aerobic respiration and is produced by a number of reactions, including oxidative phosphorylation and photosynthesis. The dismutase enzymes have a very high catalytic efficiency due to the attraction of superoxide to the ions bound at the active site [PubMed1463506, PubMed3891411].

There are three forms of superoxide dismutase, depending on the metal cofactor: Cu/Zn (which binds both copper and zinc), Fe and Mn types. The Fe and Mn forms are similar in their primary, secondary and tertiary structures, but are distinct from the Cu/Zn form [PubMed2263641]. Prokaryotes and protists contain Mn, Fe or both types, while most eukaryotic organisms utilise the Cu/Zn type.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cu,Zn superoxide dismutase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Cu,Zn superoxide dismutase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]