SUPERFAMILY 1.75 HMM library and genome assignments server

Cu,Zn superoxide dismutase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Cu,Zn superoxide dismutase-like [ 49329]
Families:   Cu,Zn superoxide dismutase-like [ 49330] (2)


Superfamily statistics
Genomes (1,366) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,156 10,448 50
Proteins 2,898 10,168 50


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)developmental process0.000000000049960.0009795Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.000080930.0001398Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.45760.9624Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.40440.9583Least InformativeInherited
Biological Process (BP)single-organism cellular process0.000023650.002933Least InformativeInherited
Biological Process (BP)biosynthetic process0.056020.1875Least InformativeInherited
Biological Process (BP)regulation of cellular process0.341Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.000015490.1382Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.66740.581Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0000000077150.009549Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.56071Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.00083210.1071Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.4150.9855Least InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0000000000000016880Moderately InformativeDirect
Biological Process (BP)reproduction0.000000000000070980.0000003293Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00000000000022610.00000000006794Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.0000000000010230.00000000000002631Moderately InformativeDirect
Biological Process (BP)cellular response to stress0.0000000000031120.000000002658Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.000000000051920.000000009944Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.00000000022210.00009009Moderately InformativeDirect
Biological Process (BP)cellular amino acid metabolic process0.00000000026170.000000004363Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.00000000028660.0001141Moderately InformativeDirect
Biological Process (BP)immune system process0.00000000058990.00001207Moderately InformativeDirect
Biological Process (BP)sulfur compound metabolic process0.0000000069560.000000001229Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.000000013170.00000000009348Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.00000039820.00000129Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.0000021780.0002374Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus0.0000055770.000004634Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.000009470.0000000000137Moderately InformativeDirect
Biological Process (BP)system process0.000011010.00005277Moderately InformativeDirect
Biological Process (BP)nervous system development0.000012270.0005324Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00001760.00002267Moderately InformativeDirect
Biological Process (BP)tissue development0.000026840.0003239Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.000032010.004825Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.018220.2717Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.000015080.01109Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.0000001053Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.00000011290.02096Moderately InformativeInherited
Biological Process (BP)response to organic substance0.73861Moderately InformativeInherited
Biological Process (BP)organelle organization0.0021940.09504Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.00000015320.005006Moderately InformativeInherited
Biological Process (BP)cell differentiation0.000000015580.01472Moderately InformativeInherited
Biological Process (BP)organ development0.0086490.01319Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.015160.01548Moderately InformativeInherited
Biological Process (BP)muscle system process00InformativeDirect
Biological Process (BP)peptide metabolic process00InformativeDirect
Biological Process (BP)cation homeostasis00InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process00InformativeDirect
Biological Process (BP)response to inorganic substance00InformativeDirect
Biological Process (BP)multi-multicellular organism process00InformativeDirect
Biological Process (BP)blood circulation00InformativeDirect
Biological Process (BP)response to oxidative stress00InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis00.0000000000002071InformativeDirect
Biological Process (BP)regulation of kinase activity00.0000000000007909InformativeDirect
Biological Process (BP)reproductive system development00.000000000002158InformativeDirect
Biological Process (BP)regulation of protein phosphorylation00.00000000005175InformativeDirect
Biological Process (BP)single-organism behavior00.00000000005555InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade00.0000000007164InformativeDirect
Biological Process (BP)epithelium development0.0000000000000063980.00000008123InformativeDirect
Biological Process (BP)apoptotic process0.000000000000018560.0000000002351InformativeDirect
Biological Process (BP)regulation of lipid metabolic process0.000000000000030450InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.000000000000036250.00000001166InformativeDirect
Biological Process (BP)generation of neurons0.000000000000045040.000003441InformativeDirect
Biological Process (BP)cytoskeleton organization0.00000000000011670.00000003805InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00000000000012350.000000000000005594InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.00000000000054180.000000006749InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.00000000000055180.000000000008405InformativeDirect
Biological Process (BP)DNA metabolic process0.00000000000071730.0000003509InformativeDirect
Biological Process (BP)regulation of growth0.0000000000040020.00000002505InformativeDirect
Biological Process (BP)embryonic organ development0.0000000000065870.000000002273InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process0.000000000020620.00000001533InformativeDirect
Biological Process (BP)cellular membrane organization0.000000000062470.0000000005935InformativeDirect
Biological Process (BP)cell projection organization0.00000000021470.00001398InformativeDirect
Biological Process (BP)regulation of cytokine production0.00000000052750.00000000001211InformativeDirect
Biological Process (BP)embryonic morphogenesis0.0000000007470.0000007665InformativeDirect
Biological Process (BP)single organism reproductive process0.0000000013550.00001037InformativeDirect
Biological Process (BP)sensory organ development0.0000000027880.0000006767InformativeDirect
Biological Process (BP)negative regulation of cell death0.0000000040490.00000000006746InformativeDirect
Biological Process (BP)regulation of anatomical structure size0.0000000047170.0000004657InformativeDirect
Biological Process (BP)cellular component morphogenesis0.0000000094510.000008183InformativeDirect
Biological Process (BP)regulation of system process0.000000017440.000000004403InformativeDirect
Biological Process (BP)negative regulation of biosynthetic process0.00000021640.00002882InformativeDirect
Biological Process (BP)developmental process involved in reproduction0.00000058350.000001336InformativeDirect
Biological Process (BP)organ morphogenesis0.00000061510.0002737InformativeDirect
Biological Process (BP)positive regulation of protein metabolic process0.000008680.0000008973InformativeDirect
Biological Process (BP)response to light stimulus0.000014540.00002041InformativeDirect
Biological Process (BP)multicellular organismal reproductive process0.000020530.0006418InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.000038040.00004399InformativeDirect
Biological Process (BP)cellular chemical homeostasis0.0004020.0003746InformativeDirect
Biological Process (BP)response to wounding0.00083420.04324InformativeInherited
Biological Process (BP)sexual reproduction0.0003390.003254InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.41410.9719InformativeInherited
Biological Process (BP)double-strand break repair00Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process00Highly InformativeDirect
Biological Process (BP)response to superoxide00Highly InformativeDirect
Biological Process (BP)regulation of muscle contraction00Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)negative regulation of neuron death00Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species00Highly InformativeDirect
Biological Process (BP)ear development00Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production00Highly InformativeDirect
Biological Process (BP)response to axon injury00Highly InformativeDirect
Biological Process (BP)epidermal cell differentiation00Highly InformativeDirect
Biological Process (BP)regulation of MAP kinase activity00Highly InformativeDirect
Biological Process (BP)ovulation cycle process00Highly InformativeDirect
Biological Process (BP)DNA catabolic process00Highly InformativeDirect
Biological Process (BP)glutathione metabolic process00Highly InformativeDirect
Biological Process (BP)execution phase of apoptosis00Highly InformativeDirect
Biological Process (BP)superoxide metabolic process00Highly InformativeDirect
Biological Process (BP)heart contraction00Highly InformativeDirect
Biological Process (BP)vascular process in circulatory system00Highly InformativeDirect
Biological Process (BP)development of primary female sexual characteristics00Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process00Highly InformativeDirect
Biological Process (BP)regulation of multicellular organism growth00Highly InformativeDirect
Biological Process (BP)glial cell differentiation00Highly InformativeDirect
Biological Process (BP)transition metal ion homeostasis00Highly InformativeDirect
Biological Process (BP)aging00Highly InformativeDirect
Biological Process (BP)epithelial cell development00.000000000000001938Highly InformativeDirect
Biological Process (BP)locomotory behavior00.000000000000003755Highly InformativeDirect
Biological Process (BP)embryonic organ morphogenesis00.000000000000003755Highly InformativeDirect
Biological Process (BP)positive regulation of MAPK cascade00.00000000000003788Highly InformativeDirect
Biological Process (BP)cellular component disassembly00.00000000000006398Highly InformativeDirect
Biological Process (BP)spermatogenesis00.0000000000001488Highly InformativeDirect
Biological Process (BP)sensory perception00.0000000000003137Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic process00.000000000009394Highly InformativeDirect
Biological Process (BP)cell morphogenesis involved in differentiation00.000000004281Highly InformativeDirect
Biological Process (BP)regulation of blood pressure0.0000000000000032610.0000000000004496Highly InformativeDirect
Biological Process (BP)gonad development0.00000000000000950.00000000000005099Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.00000000000010030.0000000000002418Highly InformativeDirect
Biological Process (BP)regulation of membrane potential0.00000000000030360.000000001335Highly InformativeDirect
Biological Process (BP)response to heat0.000000022370.0000008778Highly InformativeDirect
Biological Process (BP)response to UV0.000000047080.000000006818Highly InformativeDirect
Biological Process (BP)response to drug0.0000029750.00007371Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase activity0.000025450.0001513Highly InformativeDirect
Biological Process (BP)response to alcohol0.000062480.0002758Highly InformativeDirect
Biological Process (BP)female pregnancy0.00068340.00008191Highly InformativeDirect
Biological Process (BP)hydrogen peroxide metabolic process0.94151Highly InformativeInherited
Molecular Function (MF)binding0.000019710.0006449Least InformativeDirect
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)cation binding0.00000000000004360Moderately InformativeDirect
Molecular Function (MF)enzyme binding0.0000000000009580.000000002292InformativeDirect
Molecular Function (MF)protein phosphatase binding00Highly InformativeDirect
Molecular Function (MF)copper ion binding00Highly InformativeDirect
Molecular Function (MF)antioxidant activity00Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0000072510.00002045Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.00019070.00008985Least InformativeDirect
Cellular Component (CC)extracellular region part0.0000000000033260Moderately InformativeDirect
Cellular Component (CC)cell projection0.0000000045970.0000719Moderately InformativeDirect
Cellular Component (CC)cytosol0.00000012410.0000002332Moderately InformativeDirect
Cellular Component (CC)vesicle0.00000021310.000003636Moderately InformativeDirect
Cellular Component (CC)extracellular matrix00InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)neuron projection00.0000000006659InformativeDirect
Cellular Component (CC)dendrite00.000000000000007579Highly InformativeDirect
Cellular Component (CC)cell body00.000000000005913Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0.0009795 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0001398 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.9624 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.9583 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.002933 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.1875 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1382 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.581 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.009549 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1071 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.9855 Least Informative Inherited
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000003293 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000000006794 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00000000000002631 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.000000002658 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000009944 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00009009 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.000000004363 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0001141 Moderately Informative Direct
Biological Process (BP) immune system process 0.00001207 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.000000001229 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000000009348 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.00000129 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0002374 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000004634 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0000000000137 Moderately Informative Direct
Biological Process (BP) system process 0.00005277 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0005324 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00002267 Moderately Informative Direct
Biological Process (BP) tissue development 0.0003239 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0000001053 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.004825 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2717 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01109 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.02096 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.09504 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.005006 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.01472 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.01319 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01548 Moderately Informative Inherited
Biological Process (BP) muscle system process 0 Informative Direct
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) response to inorganic substance 0 Informative Direct
Biological Process (BP) multi-multicellular organism process 0 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) response to oxidative stress 0 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.0000000000002071 Informative Direct
Biological Process (BP) regulation of kinase activity 0.0000000000007909 Informative Direct
Biological Process (BP) reproductive system development 0.000000000002158 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.00000000005175 Informative Direct
Biological Process (BP) single-organism behavior 0.00000000005555 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0000000007164 Informative Direct
Biological Process (BP) epithelium development 0.00000008123 Informative Direct
Biological Process (BP) apoptotic process 0.0000000002351 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.00000001166 Informative Direct
Biological Process (BP) generation of neurons 0.000003441 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000003805 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.000000000000005594 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000000006749 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000000000008405 Informative Direct
Biological Process (BP) DNA metabolic process 0.0000003509 Informative Direct
Biological Process (BP) regulation of growth 0.00000002505 Informative Direct
Biological Process (BP) embryonic organ development 0.000000002273 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.00000001533 Informative Direct
Biological Process (BP) cellular membrane organization 0.0000000005935 Informative Direct
Biological Process (BP) cell projection organization 0.00001398 Informative Direct
Biological Process (BP) regulation of cytokine production 0.00000000001211 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0000007665 Informative Direct
Biological Process (BP) single organism reproductive process 0.00001037 Informative Direct
Biological Process (BP) sensory organ development 0.0000006767 Informative Direct
Biological Process (BP) negative regulation of cell death 0.00000000006746 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0000004657 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000008183 Informative Direct
Biological Process (BP) regulation of system process 0.000000004403 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.00002882 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.000001336 Informative Direct
Biological Process (BP) organ morphogenesis 0.0002737 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.0000008973 Informative Direct
Biological Process (BP) response to light stimulus 0.00002041 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0006418 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.00004399 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0003746 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0007702 Informative Direct
Biological Process (BP) response to wounding 0.04324 Informative Inherited
Biological Process (BP) sexual reproduction 0.003254 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.9719 Informative Inherited
Biological Process (BP) double-strand break repair 0 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) response to superoxide 0 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0 Highly Informative Direct
Biological Process (BP) ear development 0 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) response to axon injury 0 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) DNA catabolic process 0 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) execution phase of apoptosis 0 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 0 Highly Informative Direct
Biological Process (BP) heart contraction 0 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.000000000000001938 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.000000000000003755 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.000000000000003755 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.00000000000003788 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.00000000000006398 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0000000000001488 Highly Informative Direct
Biological Process (BP) sensory perception 0.0000000000003137 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.000000000009394 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000000004281 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0000000000004496 Highly Informative Direct
Biological Process (BP) gonad development 0.00000000000005099 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0000000000002418 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.000000001335 Highly Informative Direct
Biological Process (BP) response to heat 0.0000008778 Highly Informative Direct
Biological Process (BP) response to UV 0.000000006818 Highly Informative Direct
Biological Process (BP) response to drug 0.00007371 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0001513 Highly Informative Direct
Biological Process (BP) response to alcohol 0.0002758 Highly Informative Direct
Biological Process (BP) female pregnancy 0.00008191 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Molecular Function (MF) binding 0.0006449 Least Informative Direct
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme binding 0.000000002292 Informative Direct
Molecular Function (MF) protein phosphatase binding 0 Highly Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) antioxidant activity 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00002045 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00008985 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000719 Moderately Informative Direct
Cellular Component (CC) cytosol 0.0000002332 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000003636 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.008548 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.02519 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) neuron projection 0.0000000006659 Informative Direct
Cellular Component (CC) microbody 0.00004241 Informative Direct
Cellular Component (CC) dendrite 0.000000000000007579 Highly Informative Direct
Cellular Component (CC) cell body 0.000000000005913 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Superoxide dismutase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0Least InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)life span variant0.00008969InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on superoxide as acceptor1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentPlastid0.02563Moderately InformativeInherited
Cellular componentPeriplasm0.00000000000001995InformativeDirect
Cellular componentHost cytoplasm0.0000000065InformativeDirect
Cellular componentChloroplast0.0003003InformativeDirect
DomainSignal0.0000000001783Least InformativeDirect
DomainTransit peptide0.00003015Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCopper0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationAntioxidant0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate0.0000003193Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001424 SSF49329 Protein matches
Abstract

Superoxide dismutases are ubiquitous metalloproteins that prevent damage by oxygen-mediated free radicals by catalysing the dismutation of superoxide into molecular oxygen and hydrogen peroxide [PubMed2751312]. Superoxide is a normal by-product of aerobic respiration and is produced by a number of reactions, including oxidative phosphorylation and photosynthesis. The dismutase enzymes have a very high catalytic efficiency due to the attraction of superoxide to the ions bound at the active site [PubMed1463506, PubMed3891411].

There are three forms of superoxide dismutase, depending on the metal cofactor: Cu/Zn (which binds both copper and zinc), Fe and Mn types. The Fe and Mn forms are similar in their primary, secondary and tertiary structures, but are distinct from the Cu/Zn form [PubMed2263641]. Prokaryotes and protists contain Mn, Fe or both types, while most eukaryotic organisms utilise the Cu/Zn type.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cu,Zn superoxide dismutase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Cu,Zn superoxide dismutase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]