SUPERFAMILY 1.75 HMM library and genome assignments server


Cu,Zn superoxide dismutase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Cu,Zn superoxide dismutase-like [ 49329]
Families:   Cu,Zn superoxide dismutase-like [ 49330] (2)


Superfamily statistics
Genomes (1,321) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 3,024 6,073 50
Proteins 2,794 5,858 50


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus1.712e-121.498e-11Least InformativeDirect
Biological Process (BP)developmental process2.146e-110.0004999Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.38170.8123Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.33590.8171Least InformativeInherited
Biological Process (BP)single-organism cellular process0.056480.4453Least InformativeInherited
Biological Process (BP)biosynthetic process0.036020.09156Least InformativeInherited
Biological Process (BP)regulation of cellular process0.36531Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis1.2e-050.08636Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.73610.5362Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.00010430.00172Least InformativeInherited
Biological Process (BP)multicellular organismal process4.295e-090.005021Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.50061Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.00052190.0876Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.35090.855Least InformativeInherited
Biological Process (BP)positive regulation of molecular function03.198e-11Moderately InformativeDirect
Biological Process (BP)reproduction4.866e-141.853e-07Moderately InformativeDirect
Biological Process (BP)multi-organism process7.19e-141.334e-10Moderately InformativeDirect
Biological Process (BP)regulation of programmed cell death1.057e-125.69e-08Moderately InformativeDirect
Biological Process (BP)macromolecule catabolic process3.1e-116.725e-08Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction8.31e-114.639e-05Moderately InformativeDirect
Biological Process (BP)cellular amino acid metabolic process1.527e-102.732e-09Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process2.694e-102.499e-07Moderately InformativeDirect
Biological Process (BP)immune system process3.592e-105.197e-06Moderately InformativeDirect
Biological Process (BP)sulfur compound metabolic process3.547e-093.061e-10Moderately InformativeDirect
Biological Process (BP)organic cyclic compound catabolic process1.353e-081.167e-07Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus3.292e-083.263e-09Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus7.694e-085.702e-08Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process1.01e-070.0004865Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process1.141e-070.0001147Moderately InformativeDirect
Biological Process (BP)cellular response to stress2.737e-074.482e-05Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus4.396e-076.184e-07Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound2.616e-061.516e-07Moderately InformativeDirect
Biological Process (BP)system process8.968e-064.681e-05Moderately InformativeDirect
Biological Process (BP)nervous system development1.183e-050.0005027Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process1.377e-051.978e-05Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity1.424e-053.437e-06Moderately InformativeDirect
Biological Process (BP)tissue development2.291e-050.0002905Moderately InformativeDirect
Biological Process (BP)homeostatic process4.914e-050.0001731Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process3.4e-050.002728Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.016940.2637Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process1.202e-050.006146Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process15.994e-08Moderately InformativeInherited
Biological Process (BP)response to organic substance0.1180.5565Moderately InformativeInherited
Biological Process (BP)organelle organization5.588e-050.01082Moderately InformativeInherited
Biological Process (BP)cell differentiation6.102e-090.00872Moderately InformativeInherited
Biological Process (BP)organ development0.0068510.01144Moderately InformativeInherited
Biological Process (BP)single-organism developmental process2.603e-080.001577Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.01140.006808Moderately InformativeInherited
Biological Process (BP)cation homeostasis00InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process00InformativeDirect
Biological Process (BP)cellular amide metabolic process00InformativeDirect
Biological Process (BP)blood circulation00InformativeDirect
Biological Process (BP)response to oxidative stress00InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis02.052e-13InformativeDirect
Biological Process (BP)regulation of kinase activity04.896e-13InformativeDirect
Biological Process (BP)single-organism behavior01.867e-11InformativeDirect
Biological Process (BP)regulation of protein phosphorylation02.367e-11InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade02.893e-10InformativeDirect
Biological Process (BP)epithelium development3.152e-154.34e-08InformativeDirect
Biological Process (BP)positive regulation of signal transduction1.207e-145.369e-09InformativeDirect
Biological Process (BP)regulation of lipid metabolic process2.071e-140InformativeDirect
Biological Process (BP)generation of neurons2.071e-141.906e-06InformativeDirect
Biological Process (BP)cytoskeleton organization7.591e-142.079e-08InformativeDirect
Biological Process (BP)transmission of nerve impulse9.172e-148.648e-11InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process3.522e-135e-09InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process3.688e-134.619e-12InformativeDirect
Biological Process (BP)DNA metabolic process5.993e-132.657e-07InformativeDirect
Biological Process (BP)response to inorganic substance8.582e-130InformativeDirect
Biological Process (BP)cell projection organization1.252e-123.839e-07InformativeDirect
Biological Process (BP)membrane organization1.516e-121.942e-12InformativeDirect
Biological Process (BP)regulation of growth1.66e-123.198e-10InformativeDirect
Biological Process (BP)reproductive structure development3.292e-121.133e-12InformativeDirect
Biological Process (BP)embryonic organ development4.569e-122.12e-09InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process1.054e-111.12e-08InformativeDirect
Biological Process (BP)single organism reproductive process8.112e-111.131e-06InformativeDirect
Biological Process (BP)regulation of cytokine production4.341e-101.22e-11InformativeDirect
Biological Process (BP)embryonic morphogenesis6.374e-107.983e-07InformativeDirect
Biological Process (BP)cell death7.517e-103.45e-08InformativeDirect
Biological Process (BP)sensory organ development2.175e-096.606e-07InformativeDirect
Biological Process (BP)negative regulation of cell death3.648e-095.875e-11InformativeDirect
Biological Process (BP)regulation of anatomical structure size3.729e-091.389e-07InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound5.93e-092.233e-09InformativeDirect
Biological Process (BP)cellular component morphogenesis8.959e-098.131e-06InformativeDirect
Biological Process (BP)regulation of system process1.399e-083.864e-09InformativeDirect
Biological Process (BP)negative regulation of biosynthetic process2.071e-072.48e-05InformativeDirect
Biological Process (BP)organ morphogenesis4.426e-070.0002369InformativeDirect
Biological Process (BP)positive regulation of protein metabolic process9.375e-068.064e-07InformativeDirect
Biological Process (BP)response to light stimulus1.103e-051.537e-05InformativeDirect
Biological Process (BP)multicellular organismal reproductive process2.333e-050.0006038InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process2.533e-053.908e-05InformativeDirect
Biological Process (BP)cellular chemical homeostasis0.00077427.427e-05InformativeDirect
Biological Process (BP)response to wounding9.815e-050.0103InformativeInherited
Biological Process (BP)sexual reproduction0.00033320.002993InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.046770.2859InformativeInherited
Biological Process (BP)double-strand break repair00Highly InformativeDirect
Biological Process (BP)locomotory behavior00Highly InformativeDirect
Biological Process (BP)epithelial cell development00Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process00Highly InformativeDirect
Biological Process (BP)response to superoxide00Highly InformativeDirect
Biological Process (BP)regulation of muscle contraction00Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)negative regulation of neuron death00Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production00Highly InformativeDirect
Biological Process (BP)response to axon injury00Highly InformativeDirect
Biological Process (BP)epidermal cell differentiation00Highly InformativeDirect
Biological Process (BP)regulation of MAP kinase activity00Highly InformativeDirect
Biological Process (BP)plasma membrane organization00Highly InformativeDirect
Biological Process (BP)ovulation cycle process00Highly InformativeDirect
Biological Process (BP)DNA catabolic process00Highly InformativeDirect
Biological Process (BP)cellular component disassembly00Highly InformativeDirect
Biological Process (BP)glutathione metabolic process00Highly InformativeDirect
Biological Process (BP)execution phase of apoptosis00Highly InformativeDirect
Biological Process (BP)heart contraction00Highly InformativeDirect
Biological Process (BP)vascular process in circulatory system00Highly InformativeDirect
Biological Process (BP)development of primary female sexual characteristics00Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process00Highly InformativeDirect
Biological Process (BP)regulation of multicellular organism growth00Highly InformativeDirect
Biological Process (BP)glial cell differentiation00Highly InformativeDirect
Biological Process (BP)transition metal ion homeostasis00Highly InformativeDirect
Biological Process (BP)aging00Highly InformativeDirect
Biological Process (BP)response to ethanol00Highly InformativeDirect
Biological Process (BP)embryonic organ morphogenesis03.746e-15Highly InformativeDirect
Biological Process (BP)positive regulation of MAPK cascade01.263e-14Highly InformativeDirect
Biological Process (BP)inner ear development03.114e-14Highly InformativeDirect
Biological Process (BP)spermatogenesis07.325e-14Highly InformativeDirect
Biological Process (BP)sensory perception01.717e-13Highly InformativeDirect
Biological Process (BP)cell morphogenesis involved in differentiation02.495e-09Highly InformativeDirect
Biological Process (BP)regulation of blood pressure1.61e-152.875e-13Highly InformativeDirect
Biological Process (BP)gonad development1.207e-144.427e-14Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process1.261e-132.846e-13Highly InformativeDirect
Biological Process (BP)regulation of membrane potential1.799e-134.465e-10Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species1.018e-120Highly InformativeDirect
Biological Process (BP)response to heat7.192e-108.24e-08Highly InformativeDirect
Biological Process (BP)response to UV4.234e-086.384e-09Highly InformativeDirect
Biological Process (BP)response to drug5.882e-081.759e-06Highly InformativeDirect
Biological Process (BP)superoxide metabolic process1.752e-061.605e-08Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase activity3.516e-050.0002098Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide0.00044040.0009864Highly InformativeDirect
Biological Process (BP)female pregnancy0.00098120.0001016Highly InformativeDirect
Biological Process (BP)hydrogen peroxide metabolic process0.87240.9535Highly InformativeInherited
Biological Process (BP)tissue homeostasis0.0021013.522e-05Highly InformativeInherited
Molecular Function (MF)binding1.243e-050.0005929Least InformativeDirect
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)cation binding1.18e-140Moderately InformativeDirect
Molecular Function (MF)transition metal ion binding00InformativeDirect
Molecular Function (MF)enzyme binding5.931e-131.043e-09InformativeDirect
Molecular Function (MF)copper ion binding00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part4.536e-074.398e-05Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle5.688e-067.825e-06Least InformativeDirect
Cellular Component (CC)extracellular region part5.447e-140Moderately InformativeDirect
Cellular Component (CC)cell projection5.171e-102.048e-05Moderately InformativeDirect
Cellular Component (CC)vesicle6.714e-092.192e-06Moderately InformativeDirect
Cellular Component (CC)cytosol1.146e-072.259e-07Moderately InformativeDirect
Cellular Component (CC)extracellular matrix00InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)neuron projection02.342e-10InformativeDirect
Cellular Component (CC)dendrite02.972e-15Highly InformativeDirect
Cellular Component (CC)cell body01.683e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 1.498e-11 Least Informative Direct
Biological Process (BP) developmental process 0.0004999 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.8123 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.8171 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4453 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.09156 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.08636 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.5362 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.00172 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.005021 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.0876 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.855 Least Informative Inherited
Biological Process (BP) positive regulation of molecular function 3.198e-11 Moderately Informative Direct
Biological Process (BP) reproduction 1.853e-07 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.334e-10 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 5.69e-08 Moderately Informative Direct
Biological Process (BP) macromolecule catabolic process 6.725e-08 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 4.639e-05 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 2.732e-09 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 2.499e-07 Moderately Informative Direct
Biological Process (BP) immune system process 5.197e-06 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 3.061e-10 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 1.167e-07 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 3.263e-09 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 5.702e-08 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0004865 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0001147 Moderately Informative Direct
Biological Process (BP) cellular response to stress 4.482e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 6.184e-07 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1.516e-07 Moderately Informative Direct
Biological Process (BP) system process 4.681e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0005027 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.978e-05 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 3.437e-06 Moderately Informative Direct
Biological Process (BP) tissue development 0.0002905 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.0001731 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 5.994e-08 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.002728 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2637 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.006146 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.5565 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.01082 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.00872 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.01144 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.001577 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.006808 Moderately Informative Inherited
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) response to oxidative stress 0 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 2.052e-13 Informative Direct
Biological Process (BP) regulation of kinase activity 4.896e-13 Informative Direct
Biological Process (BP) single-organism behavior 1.867e-11 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 2.367e-11 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 2.893e-10 Informative Direct
Biological Process (BP) epithelium development 4.34e-08 Informative Direct
Biological Process (BP) positive regulation of signal transduction 5.369e-09 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0 Informative Direct
Biological Process (BP) generation of neurons 1.906e-06 Informative Direct
Biological Process (BP) cytoskeleton organization 2.079e-08 Informative Direct
Biological Process (BP) transmission of nerve impulse 8.648e-11 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 5e-09 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 4.619e-12 Informative Direct
Biological Process (BP) DNA metabolic process 2.657e-07 Informative Direct
Biological Process (BP) response to inorganic substance 0 Informative Direct
Biological Process (BP) cell projection organization 3.839e-07 Informative Direct
Biological Process (BP) membrane organization 1.942e-12 Informative Direct
Biological Process (BP) regulation of growth 3.198e-10 Informative Direct
Biological Process (BP) reproductive structure development 1.133e-12 Informative Direct
Biological Process (BP) embryonic organ development 2.12e-09 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 1.12e-08 Informative Direct
Biological Process (BP) single organism reproductive process 1.131e-06 Informative Direct
Biological Process (BP) regulation of cytokine production 1.22e-11 Informative Direct
Biological Process (BP) embryonic morphogenesis 7.983e-07 Informative Direct
Biological Process (BP) cell death 3.45e-08 Informative Direct
Biological Process (BP) sensory organ development 6.606e-07 Informative Direct
Biological Process (BP) negative regulation of cell death 5.875e-11 Informative Direct
Biological Process (BP) regulation of anatomical structure size 1.389e-07 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 2.233e-09 Informative Direct
Biological Process (BP) cellular component morphogenesis 8.131e-06 Informative Direct
Biological Process (BP) regulation of system process 3.864e-09 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 2.48e-05 Informative Direct
Biological Process (BP) organ morphogenesis 0.0002369 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 8.064e-07 Informative Direct
Biological Process (BP) response to light stimulus 1.537e-05 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0006038 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 3.908e-05 Informative Direct
Biological Process (BP) cellular chemical homeostasis 7.427e-05 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0006143 Informative Direct
Biological Process (BP) response to wounding 0.0103 Informative Inherited
Biological Process (BP) sexual reproduction 0.002993 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.2859 Informative Inherited
Biological Process (BP) double-strand break repair 0 Highly Informative Direct
Biological Process (BP) locomotory behavior 0 Highly Informative Direct
Biological Process (BP) epithelial cell development 0 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) response to superoxide 0 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) response to axon injury 0 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) DNA catabolic process 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) execution phase of apoptosis 0 Highly Informative Direct
Biological Process (BP) heart contraction 0 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) response to ethanol 0 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 3.746e-15 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 1.263e-14 Highly Informative Direct
Biological Process (BP) inner ear development 3.114e-14 Highly Informative Direct
Biological Process (BP) spermatogenesis 7.325e-14 Highly Informative Direct
Biological Process (BP) sensory perception 1.717e-13 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 2.495e-09 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 2.875e-13 Highly Informative Direct
Biological Process (BP) gonad development 4.427e-14 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 2.846e-13 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 4.465e-10 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0 Highly Informative Direct
Biological Process (BP) response to heat 8.24e-08 Highly Informative Direct
Biological Process (BP) response to UV 6.384e-09 Highly Informative Direct
Biological Process (BP) response to drug 1.759e-06 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 1.605e-08 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0002098 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0009864 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0001016 Highly Informative Direct
Biological Process (BP) tissue homeostasis 3.522e-05 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 0.9535 Highly Informative Inherited
Molecular Function (MF) binding 0.0005929 Least Informative Direct
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) transition metal ion binding 0 Informative Direct
Molecular Function (MF) enzyme binding 1.043e-09 Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 4.398e-05 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 7.825e-06 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 2.048e-05 Moderately Informative Direct
Cellular Component (CC) vesicle 2.192e-06 Moderately Informative Direct
Cellular Component (CC) cytosol 2.259e-07 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.03409 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.07174 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) neuron projection 2.342e-10 Informative Direct
Cellular Component (CC) microbody 4.471e-05 Informative Direct
Cellular Component (CC) dendrite 2.972e-15 Highly Informative Direct
Cellular Component (CC) cell body 1.683e-12 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Superoxide dismutase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0Least InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)life span variant8.969e-05InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on superoxide as acceptor1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentPlastid0.02557Moderately InformativeInherited
Cellular componentPeriplasm2.095e-14InformativeDirect
Cellular componentHost cytoplasm5.369e-09InformativeDirect
Cellular componentChloroplast0.0002908InformativeDirect
DomainSignal1.572e-10Least InformativeDirect
DomainTransit peptide2.773e-05Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCopper0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationAntioxidant0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate2.781e-07Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001424 SSF49329 Protein matches
Abstract

Superoxide dismutases are ubiquitous metalloproteins that prevent damage by oxygen-mediated free radicals by catalysing the dismutation of superoxide into molecular oxygen and hydrogen peroxide [PubMed2751312]. Superoxide is a normal by-product of aerobic respiration and is produced by a number of reactions, including oxidative phosphorylation and photosynthesis. The dismutase enzymes have a very high catalytic efficiency due to the attraction of superoxide to the ions bound at the active site [PubMed1463506, PubMed3891411].

There are three forms of superoxide dismutase, depending on the metal cofactor: Cu/Zn (which binds both copper and zinc), Fe and Mn types. The Fe and Mn forms are similar in their primary, secondary and tertiary structures, but are distinct from the Cu/Zn form [PubMed2263641]. Prokaryotes and protists contain Mn, Fe or both types, while most eukaryotic organisms utilise the Cu/Zn type.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cu,Zn superoxide dismutase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Cu,Zn superoxide dismutase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]