SUPERFAMILY 1.75 HMM library and genome assignments server


Cadherin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Cadherin-like [ 49313] (2)
Families:   Cadherin [ 49314] (3)
  Dystroglycan, N-terminal domain [ 110062]


Superfamily statistics
Genomes (857) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 71,567 89,089 29
Proteins 10,844 17,885 14


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00015870Least InformativeDirect
Biological Process (BP)reproduction5.282e-080.001706Moderately InformativeInherited
Biological Process (BP)sexual reproduction1.722e-119.377e-08InformativeDirect
Biological Process (BP)multicellular organismal reproductive process2.358e-118.42e-08InformativeDirect
Biological Process (BP)single organism reproductive process3.48e-080.001709InformativeInherited
Biological Process (BP)spermatogenesis7.346e-141.536e-07Highly InformativeDirect
Cellular Component (CC)cell junction3.354e-060InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1.308e-08 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 0.184 Least Informative Inherited
Biological Process (BP) nervous system development 3.411e-13 Moderately Informative Direct
Biological Process (BP) cell differentiation 1.002e-12 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00765 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.6837 Moderately Informative Inherited
Biological Process (BP) system process 0.009129 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.546 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1731 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.1013 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.003184 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001706 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.02668 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.5121 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.05084 Moderately Informative Inherited
Biological Process (BP) sexual reproduction 9.377e-08 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 8.42e-08 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) epithelium development 8.578e-10 Informative Direct
Biological Process (BP) locomotion 9.389e-10 Informative Direct
Biological Process (BP) localization of cell 1.873e-08 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.7e-07 Informative Direct
Biological Process (BP) nitrogen compound transport 5.165e-07 Informative Direct
Biological Process (BP) cell projection organization 9.66e-07 Informative Direct
Biological Process (BP) sensory organ development 1.76e-06 Informative Direct
Biological Process (BP) tissue morphogenesis 1.801e-06 Informative Direct
Biological Process (BP) negative regulation of developmental process 8.263e-06 Informative Direct
Biological Process (BP) organ morphogenesis 7.497e-05 Informative Direct
Biological Process (BP) synaptic transmission 0.0002104 Informative Direct
Biological Process (BP) regulation of system process 0.1659 Informative Inherited
Biological Process (BP) muscle structure development 0.7741 Informative Inherited
Biological Process (BP) organelle assembly 0.09306 Informative Inherited
Biological Process (BP) actin filament-based process 0.3726 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.001052 Informative Inherited
Biological Process (BP) embryonic organ development 0.007134 Informative Inherited
Biological Process (BP) transmembrane transport 0.02071 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.6578 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1423 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.7241 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.7339 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9923 Informative Inherited
Biological Process (BP) cellular component movement 0.004148 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.3126 Informative Inherited
Biological Process (BP) single-organism behavior 0.001938 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.6022 Informative Inherited
Biological Process (BP) growth 0.09369 Informative Inherited
Biological Process (BP) single organism reproductive process 0.001709 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.0618 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.9316 Informative Inherited
Biological Process (BP) spermatogenesis 1.536e-07 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) amide transport 0 Highly Informative Direct
Biological Process (BP) cell junction organization 2.672e-12 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 4.951e-10 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 5.918e-08 Highly Informative Direct
Biological Process (BP) glial cell differentiation 1.129e-05 Highly Informative Direct
Biological Process (BP) developmental maturation 9.709e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0001117 Highly Informative Direct
Biological Process (BP) response to cold 0.0001283 Highly Informative Direct
Biological Process (BP) ear development 0.0001295 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0001608 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.0003256 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0006285 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.000657 Highly Informative Direct
Biological Process (BP) stem cell development 0.003037 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.9119 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.5241 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.6208 Highly Informative Inherited
Biological Process (BP) sensory perception 0.5484 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.1878 Highly Informative Inherited
Biological Process (BP) ossification 0.2228 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.1669 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.001003 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.9248 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.2256 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.8371 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.2337 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.007815 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.9608 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.4883 Highly Informative Inherited
Biological Process (BP) developmental growth 0.07314 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.009499 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.006014 Highly Informative Inherited
Molecular Function (MF) binding 0.07481 Least Informative Inherited
Molecular Function (MF) transporter activity 0.01549 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.007755 Moderately Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 1.206e-10 Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 2.579e-12 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 6.075e-15 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 6.907e-06 Moderately Informative Direct
Cellular Component (CC) vesicle 0.007507 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.001166 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.9005 Moderately Informative Inherited
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 3.807e-08 Informative Direct
Cellular Component (CC) synapse part 1.793e-07 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 1.067e-06 Informative Direct
Cellular Component (CC) extracellular matrix 0.0001017 Informative Direct
Cellular Component (CC) cell leading edge 0.000572 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.3205 Informative Inherited
Cellular Component (CC) integral to plasma membrane 4.45e-10 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 1.886e-08 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 2.37e-05 Highly Informative Direct
Cellular Component (CC) centrosome 9.567e-05 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 0.8817 Highly Informative Inherited
Cellular Component (CC) adherens junction 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.8647Moderately InformativeInherited
Disease Ontology (DO)pemphigus3.325e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3347Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.737Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1295Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1442Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3643Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.3786Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.001448InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.001962InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.07185InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.3263InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.418InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.7632InformativeInherited
Mammalian Phenotype (MP)abnormal orientation of cochlear hair cell stereociliary bundles2.327e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal outer hair cell stereociliary bundle morphology8.14e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology4.488e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney development0.0003087Highly InformativeDirect
Mammalian Phenotype (MP)abnormal primary cilium morphology0.002002Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureteric bud morphology0.131Highly InformativeInherited
Mammalian Phenotype (MP)abnormal head movements0.1688Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.1628Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant4.843e-05InformativeDirect
Worm Phenotype (WP)neuron development variant0.001058InformativeInherited
Worm Phenotype (WP)axon development variant7.991e-06Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0001163Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective5.626e-09InformativeDirect
Fly Phenotype (FP)cell shape defective0.0004242Highly InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0006065Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.02003Least InformativeInherited
Fly Anatomy (FA)larva0.2236Least InformativeInherited
Fly Anatomy (FA)anatomical group0.2812Least InformativeInherited
Fly Anatomy (FA)adult0.292Least InformativeInherited
Fly Anatomy (FA)cell0.3001Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3628Least InformativeInherited
Fly Anatomy (FA)organ system0.5818Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.004317Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.008359Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.0219Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.02989Moderately InformativeInherited
Fly Anatomy (FA)adult head0.04134Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.0586Moderately InformativeInherited
Fly Anatomy (FA)neuron0.061Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.06247Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.09769Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.1235Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1281Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1579Moderately InformativeInherited
Fly Anatomy (FA)appendage0.1713Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.3002Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.3054Moderately InformativeInherited
Fly Anatomy (FA)ommatidium0.001006InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.001342InformativeInherited
Fly Anatomy (FA)sensory organ cell0.00159InformativeInherited
Fly Anatomy (FA)optic lobe neuron0.001614InformativeInherited
Fly Anatomy (FA)rhabdomeric photoreceptor cell0.002099InformativeInherited
Fly Anatomy (FA)prepupa0.02359InformativeInherited
Fly Anatomy (FA)pupa0.02819InformativeInherited
Fly Anatomy (FA)imaginal precursor0.06057InformativeInherited
Fly Anatomy (FA)cuticular specialization0.4197InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.7109Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7209Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.01533Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.5559Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.5664Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cranial placode2.965e-05InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.000398InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.0006997InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.001224InformativeInherited
Xenopus ANatomical entity (XAN)forebrain0.007366InformativeInherited
Xenopus ANatomical entity (XAN)kidney1InformativeInherited
Xenopus ANatomical entity (XAN)pronephric duct4.758e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.0005556Highly InformativeDirect
Xenopus ANatomical entity (XAN)telencephalon0.0006662Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell adhesion0InformativeDirect
Biological processVirulence0.0002756InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentGolgi apparatus2.918e-06Moderately InformativeDirect
Cellular componentEndosome0.0003393Moderately InformativeDirect
Cellular componentSecreted1Moderately InformativeInherited
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane1.457e-13Highly InformativeDirect
Cellular componentCell wall1.174e-07Highly InformativeDirect
Coding sequence diversityPolymorphism1.128e-05Moderately InformativeDirect
DiseaseDisease mutation0.0004984Least InformativeDirect
DiseaseDeafness2.423e-05InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainEGF-like domain3.104e-16InformativeDirect
DomainLaminin EGF-like domain4.032e-12Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.193e-05Moderately InformativeDirect
Post-translational modificationReceptor1.532e-05Moderately InformativeDirect
Post-translational modificationTransducer0.002394InformativeInherited
Post-translational modificationG-protein coupled receptor0.0008399Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationHydroxylation0.0009596InformativeDirect
Post-translational modificationPeptidoglycan-anchor4.789e-08Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015919 SSF49313 Protein matches
Abstract

This entry represents domains with an immunoglobulin-like beta-sandwich fold, consisting of 7 strands in two sheets with a Greek key topology. Such domains are found in cadherin, as well as at the N-terminal of dystroglycan. Dystroglycan is a cell surface receptor consisting of two subunits: alpha-dystroglycan, extracellular and highly glycosylated, and beta-dystroglycan, spanning the cell membrane. It is a pivotal member of the dystrophin-glycoprotein complex and is involved in a wide variety of important cellular processes such as the stabilisation of the muscle fiber sarcolemma or the clustering of acetylcholine receptors [PubMed11909544, PubMed15326183, PubMed16410545].

Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues of the organism which modulate a wide variety of processes including cell polarisation and migration [PubMed2197976,PubMed14570569]. Cadherin-mediated cell-cell junctions are formed as a result of interaction between extracellular domains of identical cadherins, which are located on the membranes of the neighbouring cells. The stability of these adhesive junctions is ensured by binding of the intracellular cadherin domain with the actin cytoskeleton. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro, while those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changes involving the positional segregation of cells into layers, suggesting they may play an important role in the sorting of different cell types during morphogenesis, histogenesis and regeneration. They may also be involved in the regulation of tight and gap junctions, and in the control of intercellular spacing. Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins.

Structurally, cadherins comprise a number of domains: classically, these include a signal sequence; a propeptide of around 130 residues; a single transmembrane domain and five tandemly repeated extracellular cadherin domains, 4 of which are cadherin repeats, and the fifth contains 4 conserved cysteines and a N-terminal cytoplasmic domain [PubMed11736639]. However, proteins are designated as members of the broadly defined cadherin family if they have one or more cadherin repeats. A cadherin repeat is an independently folding sequence of approximately 110 amino acids that contains motifs with the conserved sequences DRE, DXNDNAPXF, and DXD. Crystal structures have revealed that multiple cadherin domains form Ca2+-dependent rod-like structures with a conserved Ca2+-binding pocket at the domain-domain interface. Cadherins depend on calcium for their function: calcium ions bind to specific residues in each cadherin repeat to ensure its proper folding, to confer rigidity upon the extracellular domain and is essential for cadherin adhesive function and for protection against protease digestion.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cadherin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Cadherin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]