SUPERFAMILY 1.75 HMM library and genome assignments server

Cadherin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Cadherin-like [ 49313] (2)
Families:   Cadherin [ 49314] (3)
  Dystroglycan, N-terminal domain [ 110062]


Superfamily statistics
Genomes (858) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 71,589 89,089 29
Proteins 10,851 17,885 14


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00013340Least InformativeDirect
Biological Process (BP)reproductive process0.000000016840.00002811Moderately InformativeDirect
Biological Process (BP)multi-organism process0.000001070.05215Moderately InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.000000000017220.0000009225InformativeDirect
Biological Process (BP)sexual reproduction0.000000000027490.000184InformativeDirect
Biological Process (BP)single organism reproductive process0.000000098440.0007229InformativeDirect
Biological Process (BP)spermatogenesis0.000000000000073520.0000001861Highly InformativeDirect
Cellular Component (CC)cell junction0.000003370InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00000005671 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2645 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 0.2518 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) reproductive process 0.00002811 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0000000000009623 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0000000000009829 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.5956 Moderately Informative Inherited
Biological Process (BP) tissue development 0.001338 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.05215 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9457 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4624 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.009735 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.02714 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.05471 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.002158 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.0000009225 Informative Direct
Biological Process (BP) sexual reproduction 0.000184 Informative Direct
Biological Process (BP) single organism reproductive process 0.0007229 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) cell projection organization 0.0000000000002552 Informative Direct
Biological Process (BP) synaptic transmission 0.000000000001503 Informative Direct
Biological Process (BP) locomotion 0.0000000008762 Informative Direct
Biological Process (BP) localization of cell 0.00000002309 Informative Direct
Biological Process (BP) cellular component movement 0.0000001333 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000002091 Informative Direct
Biological Process (BP) nitrogen compound transport 0.0000005817 Informative Direct
Biological Process (BP) epithelium development 0.000005735 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0000227 Informative Direct
Biological Process (BP) sensory organ development 0.00002706 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0000397 Informative Direct
Biological Process (BP) neurological system process 0.0002054 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000288 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.001294 Informative Inherited
Biological Process (BP) muscle structure development 0.4562 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1131 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.06454 Informative Inherited
Biological Process (BP) actin filament-based process 0.02617 Informative Inherited
Biological Process (BP) organelle assembly 0.09685 Informative Inherited
Biological Process (BP) organ morphogenesis 0.00124 Informative Inherited
Biological Process (BP) embryonic organ development 0.02046 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7737 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.834 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.8424 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.3292 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.04019 Informative Inherited
Biological Process (BP) growth 0.3266 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.004259 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) spermatogenesis 0.0000001861 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) amide transport 0 Highly Informative Direct
Biological Process (BP) cell junction organization 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00000000001564 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.00001131 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.00001188 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.00001569 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.00005203 Highly Informative Direct
Biological Process (BP) ear development 0.0001244 Highly Informative Direct
Biological Process (BP) response to cold 0.0001323 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0001382 Highly Informative Direct
Biological Process (BP) epidermis development 0.0001852 Highly Informative Direct
Biological Process (BP) sensory perception 0.000358 Highly Informative Direct
Biological Process (BP) hair cycle process 0.000465 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0006271 Highly Informative Direct
Biological Process (BP) kidney development 0.06485 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.0326 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.00449 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.186 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.002296 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.179 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.9229 Highly Informative Inherited
Biological Process (BP) ossification 0.2037 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.009901 Highly Informative Inherited
Biological Process (BP) stem cell development 0.002616 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.2309 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.4088 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.02087 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.916 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1945 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.9301 Highly Informative Inherited
Biological Process (BP) germ cell development 0.7 Highly Informative Inherited
Biological Process (BP) developmental growth 0.4222 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.1666 Highly Informative Inherited
Molecular Function (MF) binding 0.076 Least Informative Inherited
Molecular Function (MF) transporter activity 0.01616 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.008366 Moderately Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 0.0000000001324 Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000000000003037 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.000345 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000000000002302 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.00004636 Moderately Informative Direct
Cellular Component (CC) membrane region 0.0004125 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.001223 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.008878 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.953 Moderately Informative Inherited
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) plasma membrane region 0.00000000004329 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0000000576 Informative Direct
Cellular Component (CC) integral component of membrane 0.0000005426 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.000001064 Informative Direct
Cellular Component (CC) extracellular matrix 0.00008141 Informative Direct
Cellular Component (CC) cell leading edge 0.000706 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.335 Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.000000000002941 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.000000008028 Highly Informative Direct
Cellular Component (CC) integral component of plasma membrane 0.00000003248 Highly Informative Direct
Cellular Component (CC) adherens junction 1 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 0.00172 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.8659Moderately InformativeInherited
Disease Ontology (DO)pemphigus0.00003314Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3429Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.7508Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1371Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1473Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3732Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.3772Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.00138InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.002043InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.07108InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.3311InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.4238InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.7675InformativeInherited
Mammalian Phenotype (MP)abnormal orientation of cochlear hair cell stereociliary bundles0.000002318Highly InformativeDirect
Mammalian Phenotype (MP)abnormal outer hair cell stereociliary bundle morphology0.000008144Highly InformativeDirect
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.00004546Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney development0.0002927Highly InformativeDirect
Mammalian Phenotype (MP)abnormal primary cilium morphology0.002022Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureteric bud morphology0.1357Highly InformativeInherited
Mammalian Phenotype (MP)abnormal head movements0.1521Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.1628Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.00004843InformativeDirect
Worm Phenotype (WP)neuron development variant0.001058InformativeInherited
Worm Phenotype (WP)axon development variant0.000007991Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0001163Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.000000005616InformativeDirect
Fly Phenotype (FP)cell shape defective0.0004256Highly InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0006059Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.01997Least InformativeInherited
Fly Anatomy (FA)larva0.2232Least InformativeInherited
Fly Anatomy (FA)anatomical group0.2808Least InformativeInherited
Fly Anatomy (FA)adult0.2923Least InformativeInherited
Fly Anatomy (FA)cell0.2997Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3634Least InformativeInherited
Fly Anatomy (FA)organ system0.5823Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.004302Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.008335Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.02185Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.02983Moderately InformativeInherited
Fly Anatomy (FA)adult head0.04126Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.05844Moderately InformativeInherited
Fly Anatomy (FA)neuron0.06098Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.06232Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.09749Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.1239Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1285Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1581Moderately InformativeInherited
Fly Anatomy (FA)appendage0.1717Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.301Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.3061Moderately InformativeInherited
Fly Anatomy (FA)ommatidium0.001003InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.001338InformativeInherited
Fly Anatomy (FA)sensory organ cell0.001586InformativeInherited
Fly Anatomy (FA)optic lobe neuron0.00161InformativeInherited
Fly Anatomy (FA)rhabdomeric photoreceptor cell0.002094InformativeInherited
Fly Anatomy (FA)prepupa0.02352InformativeInherited
Fly Anatomy (FA)pupa0.02814InformativeInherited
Fly Anatomy (FA)imaginal precursor0.0605InformativeInherited
Fly Anatomy (FA)cuticular specialization0.4196InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.7107Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7241Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.01574Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.5581Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.5693Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cranial placode0.00003033InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0004378InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.001216InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.001296InformativeInherited
Xenopus ANatomical entity (XAN)forebrain0.007356InformativeInherited
Xenopus ANatomical entity (XAN)kidney1InformativeInherited
Xenopus ANatomical entity (XAN)pronephric duct0.00004927Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.0006095Highly InformativeDirect
Xenopus ANatomical entity (XAN)telencephalon0.0006967Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell adhesion0InformativeDirect
Biological processVirulence0.0002762InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentGolgi apparatus0.000003064Moderately InformativeDirect
Cellular componentEndosome0.0003592Moderately InformativeDirect
Cellular componentSecreted1Moderately InformativeInherited
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane0.0000000000001445Highly InformativeDirect
Cellular componentCell wall0.0000001171Highly InformativeDirect
Coding sequence diversityPolymorphism0.00001034Moderately InformativeDirect
DiseaseDisease mutation0.0005326Least InformativeDirect
DiseaseDeafness0.00002483InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainEGF-like domain3.091e-16InformativeDirect
DomainLaminin EGF-like domain0.000000000003961Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00001174Moderately InformativeDirect
Post-translational modificationReceptor0.00001524Moderately InformativeDirect
Post-translational modificationTransducer0.002387InformativeInherited
Post-translational modificationG-protein coupled receptor0.0008387Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationHydroxylation0.0009507InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.00000004729Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015919 SSF49313 Protein matches
Abstract

This entry represents domains with an immunoglobulin-like beta-sandwich fold, consisting of 7 strands in two sheets with a Greek key topology. Such domains are found in cadherin, as well as at the N-terminal of dystroglycan. Dystroglycan is a cell surface receptor consisting of two subunits: alpha-dystroglycan, extracellular and highly glycosylated, and beta-dystroglycan, spanning the cell membrane. It is a pivotal member of the dystrophin-glycoprotein complex and is involved in a wide variety of important cellular processes such as the stabilisation of the muscle fiber sarcolemma or the clustering of acetylcholine receptors [PubMed11909544, PubMed15326183, PubMed16410545].

Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues of the organism which modulate a wide variety of processes including cell polarisation and migration [PubMed2197976,PubMed14570569]. Cadherin-mediated cell-cell junctions are formed as a result of interaction between extracellular domains of identical cadherins, which are located on the membranes of the neighbouring cells. The stability of these adhesive junctions is ensured by binding of the intracellular cadherin domain with the actin cytoskeleton. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro, while those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changes involving the positional segregation of cells into layers, suggesting they may play an important role in the sorting of different cell types during morphogenesis, histogenesis and regeneration. They may also be involved in the regulation of tight and gap junctions, and in the control of intercellular spacing. Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins.

Structurally, cadherins comprise a number of domains: classically, these include a signal sequence; a propeptide of around 130 residues; a single transmembrane domain and five tandemly repeated extracellular cadherin domains, 4 of which are cadherin repeats, and the fifth contains 4 conserved cysteines and a N-terminal cytoplasmic domain [PubMed11736639]. However, proteins are designated as members of the broadly defined cadherin family if they have one or more cadherin repeats. A cadherin repeat is an independently folding sequence of approximately 110 amino acids that contains motifs with the conserved sequences DRE, DXNDNAPXF, and DXD. Crystal structures have revealed that multiple cadherin domains form Ca2+-dependent rod-like structures with a conserved Ca2+-binding pocket at the domain-domain interface. Cadherins depend on calcium for their function: calcium ions bind to specific residues in each cadherin repeat to ensure its proper folding, to confer rigidity upon the extracellular domain and is essential for cadherin adhesive function and for protection against protease digestion.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cadherin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Cadherin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]