SUPERFAMILY 1.75 HMM library and genome assignments server


Cadherin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Cadherin-like [ 49313] (2)
Families:   Cadherin [ 49314] (3)
  Dystroglycan, N-terminal domain [ 110062]


Superfamily statistics
Genomes (852) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 66,474 0 29
Proteins 10,215 0 14


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00014260Least InformativeDirect
Biological Process (BP)reproduction4.512e-080.0007803Moderately InformativeDirect
Biological Process (BP)sexual reproduction1.451e-111.033e-07InformativeDirect
Biological Process (BP)multicellular organismal reproductive process2.057e-118.88e-08InformativeDirect
Biological Process (BP)single organism reproductive process3.465e-080.00115InformativeInherited
Biological Process (BP)spermatogenesis6.241e-147.908e-08Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 4.181e-10 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.1379 Least Informative Inherited
Biological Process (BP) response to stimulus 0.7964 Least Informative Inherited
Biological Process (BP) reproduction 0.0007803 Moderately Informative Direct
Biological Process (BP) cell differentiation 1.203e-10 Moderately Informative Direct
Biological Process (BP) nervous system development 1.393e-10 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.9385 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5707 Moderately Informative Inherited
Biological Process (BP) system process 0.001987 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4522 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.925 Moderately Informative Inherited
Biological Process (BP) tissue development 0.06194 Moderately Informative Inherited
Biological Process (BP) organ development 0.9728 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.2588 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.001964 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.003991 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.03627 Moderately Informative Inherited
Biological Process (BP) sexual reproduction 1.033e-07 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 8.88e-08 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) locomotion 2.76e-10 Informative Direct
Biological Process (BP) epithelium development 7.219e-10 Informative Direct
Biological Process (BP) cell-cell signaling 1.517e-09 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.403e-08 Informative Direct
Biological Process (BP) localization of cell 3.679e-08 Informative Direct
Biological Process (BP) transmission of nerve impulse 6.078e-08 Informative Direct
Biological Process (BP) tissue morphogenesis 9.618e-08 Informative Direct
Biological Process (BP) sensory organ development 1.246e-07 Informative Direct
Biological Process (BP) cell projection organization 1.857e-07 Informative Direct
Biological Process (BP) nitrogen compound transport 2.903e-07 Informative Direct
Biological Process (BP) organ morphogenesis 5.781e-06 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0001411 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0001451 Informative Direct
Biological Process (BP) single-organism behavior 0.0004022 Informative Direct
Biological Process (BP) regulation of system process 0.1325 Informative Inherited
Biological Process (BP) muscle structure development 0.686 Informative Inherited
Biological Process (BP) organelle assembly 0.03652 Informative Inherited
Biological Process (BP) actin filament-based process 0.2232 Informative Inherited
Biological Process (BP) embryonic organ development 0.001586 Informative Inherited
Biological Process (BP) transmembrane transport 0.01568 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.6327 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.05639 Informative Inherited
Biological Process (BP) generation of neurons 0.04721 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.6493 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.6597 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9403 Informative Inherited
Biological Process (BP) cellular component movement 0.002724 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.2801 Informative Inherited
Biological Process (BP) gland development 0.6533 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.5714 Informative Inherited
Biological Process (BP) growth 0.01178 Informative Inherited
Biological Process (BP) single organism reproductive process 0.00115 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.02443 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.8754 Informative Inherited
Biological Process (BP) spermatogenesis 7.908e-08 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) amide transport 0 Highly Informative Direct
Biological Process (BP) cell junction organization 1.67e-12 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 1.872e-10 Highly Informative Direct
Biological Process (BP) inner ear development 1.305e-09 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 4.042e-08 Highly Informative Direct
Biological Process (BP) developmental maturation 4.012e-05 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 8.065e-05 Highly Informative Direct
Biological Process (BP) response to cold 9.656e-05 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.000139 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.0003629 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0004961 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0007367 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0008442 Highly Informative Direct
Biological Process (BP) skeletal system development 0.8441 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.5419 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.4145 Highly Informative Inherited
Biological Process (BP) sensory perception 0.4731 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.2283 Highly Informative Inherited
Biological Process (BP) ossification 0.1919 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.1184 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.9168 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.2626 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.8214 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1908 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.004173 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.8839 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.4842 Highly Informative Inherited
Biological Process (BP) developmental growth 0.05013 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.00595 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.002367 Highly Informative Inherited
Molecular Function (MF) binding 0.0153 Least Informative Inherited
Molecular Function (MF) transporter activity 0.01095 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.00385 Moderately Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 7.562e-11 Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 1.059e-12 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1.608e-15 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 8.299e-06 Moderately Informative Direct
Cellular Component (CC) vesicle 0.009314 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.001279 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.8351 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 4.15e-08 Informative Direct
Cellular Component (CC) synapse part 5.926e-08 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 1.286e-06 Informative Direct
Cellular Component (CC) extracellular matrix 5.395e-05 Informative Direct
Cellular Component (CC) cell-cell junction 0.0005437 Informative Direct
Cellular Component (CC) cell leading edge 0.0005854 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.2789 Informative Inherited
Cellular Component (CC) nonmotile primary cilium 5.963e-14 Highly Informative Direct
Cellular Component (CC) microvillus 1.958e-13 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 4.801e-10 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 1.068e-08 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 1.317e-05 Highly Informative Direct
Cellular Component (CC) centrosome 7.234e-05 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) adherens junction 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.871Moderately InformativeInherited
Disease Ontology (DO)pemphigus2.849e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3382Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.7204Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1283Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1468Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3609Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.001388InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.001836InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.07241InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.3137InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.412InformativeInherited
Mammalian Phenotype (MP)abnormal orientation of cochlear hair cell stereociliary bundles2.061e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal outer hair cell stereociliary bundle morphology5.783e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology4.658e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney development0.0003017Highly InformativeDirect
Mammalian Phenotype (MP)abnormal primary cilium morphology0.001907Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureteric bud morphology0.1347Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.1628Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant4.843e-05InformativeDirect
Worm Phenotype (WP)neuron development variant0.001058InformativeInherited
Worm Phenotype (WP)axon development variant7.991e-06Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0001163Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective4.182e-09InformativeDirect
Fly Phenotype (FP)cell shape defective0.0004013Highly InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0006577Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.02204Least InformativeInherited
Fly Anatomy (FA)larva0.2305Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3106Least InformativeInherited
Fly Anatomy (FA)cell0.3245Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3897Least InformativeInherited
Fly Anatomy (FA)organ system0.5922Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.00495Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.009231Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.02018Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.02444Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.0645Moderately InformativeInherited
Fly Anatomy (FA)neuron0.06774Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.08439Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.144Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1454Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1496Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1703Moderately InformativeInherited
Fly Anatomy (FA)appendage0.1906Moderately InformativeInherited
Fly Anatomy (FA)head0.2099Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.3214Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.3277Moderately InformativeInherited
Fly Anatomy (FA)prepupa0.02806InformativeInherited
Fly Anatomy (FA)pupa0.033InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.06306InformativeInherited
Fly Anatomy (FA)imaginal precursor0.06968InformativeInherited
Fly Anatomy (FA)cuticular specialization0.4406InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.7113Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7182Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.01424Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.5476Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.561Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cranial placode0.0002675InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0003454InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.0009433InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.001045InformativeInherited
Xenopus ANatomical entity (XAN)forebrain0.006641InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.9984InformativeInherited
Xenopus ANatomical entity (XAN)pronephric duct4.431e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.0005048Highly InformativeDirect
Xenopus ANatomical entity (XAN)telencephalon0.0006654Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell adhesion0InformativeDirect
Biological processVirulence0.000247InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentGolgi apparatus2.959e-06Moderately InformativeDirect
Cellular componentEndosome0.0003419Moderately InformativeDirect
Cellular componentSecreted1Moderately InformativeInherited
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane1.488e-13Highly InformativeDirect
Cellular componentCell wall1.092e-07Highly InformativeDirect
Coding sequence diversityPolymorphism1.13e-05Moderately InformativeDirect
DiseaseDisease mutation0.0004984Least InformativeDirect
DiseaseDeafness2.423e-05InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainEGF-like domain3.093e-16InformativeDirect
DomainLaminin EGF-like domain4.092e-12Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.217e-05Moderately InformativeDirect
Post-translational modificationReceptor1.565e-05Moderately InformativeDirect
Post-translational modificationTransducer0.002419InformativeInherited
Post-translational modificationG-protein coupled receptor0.0008487Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationHydroxylation0.0009743InformativeDirect
Post-translational modificationPeptidoglycan-anchor4.891e-08Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015919 SSF49313 Protein matches
Abstract

This entry represents domains with an immunoglobulin-like beta-sandwich fold, consisting of 7 strands in two sheets with a Greek key topology. Such domains are found in cadherin, as well as at the N-terminal of dystroglycan. Dystroglycan is a cell surface receptor consisting of two subunits: alpha-dystroglycan, extracellular and highly glycosylated, and beta-dystroglycan, spanning the cell membrane. It is a pivotal member of the dystrophin-glycoprotein complex and is involved in a wide variety of important cellular processes such as the stabilisation of the muscle fiber sarcolemma or the clustering of acetylcholine receptors [PubMed11909544, PubMed15326183, PubMed16410545].

Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues of the organism which modulate a wide variety of processes including cell polarisation and migration [PubMed2197976,PubMed14570569]. Cadherin-mediated cell-cell junctions are formed as a result of interaction between extracellular domains of identical cadherins, which are located on the membranes of the neighbouring cells. The stability of these adhesive junctions is ensured by binding of the intracellular cadherin domain with the actin cytoskeleton. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro, while those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changes involving the positional segregation of cells into layers, suggesting they may play an important role in the sorting of different cell types during morphogenesis, histogenesis and regeneration. They may also be involved in the regulation of tight and gap junctions, and in the control of intercellular spacing. Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins.

Structurally, cadherins comprise a number of domains: classically, these include a signal sequence; a propeptide of around 130 residues; a single transmembrane domain and five tandemly repeated extracellular cadherin domains, 4 of which are cadherin repeats, and the fifth contains 4 conserved cysteines and a N-terminal cytoplasmic domain [PubMed11736639]. However, proteins are designated as members of the broadly defined cadherin family if they have one or more cadherin repeats. A cadherin repeat is an independently folding sequence of approximately 110 amino acids that contains motifs with the conserved sequences DRE, DXNDNAPXF, and DXD. Crystal structures have revealed that multiple cadherin domains form Ca2+-dependent rod-like structures with a conserved Ca2+-binding pocket at the domain-domain interface. Cadherins depend on calcium for their function: calcium ions bind to specific residues in each cadherin repeat to ensure its proper folding, to confer rigidity upon the extracellular domain and is essential for cadherin adhesive function and for protection against protease digestion.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cadherin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Cadherin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]