SUPERFAMILY 1.75 HMM library and genome assignments server


Transglutaminase, two C-terminal domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Transglutaminase, two C-terminal domains [ 49309]
Families:   Transglutaminase, two C-terminal domains [ 49310]


Superfamily statistics
Genomes (150) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,570 1,723 16
Proteins 832 931 8


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 1.099e-10 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.337e-07 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 3.477e-05 Least Informative Direct
Biological Process (BP) response to stimulus 0.1851 Least Informative Inherited
Biological Process (BP) developmental process 0.02237 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9079 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01065 Least Informative Inherited
Biological Process (BP) immune system process 0.0001177 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 2.167e-07 Moderately Informative Direct
Biological Process (BP) organ development 0.0001058 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 5.456e-10 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.4957 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.02262 Moderately Informative Inherited
Biological Process (BP) response to wounding 1.11e-06 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.0001582 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.828e-06 Informative Direct
Biological Process (BP) cation homeostasis 1.047e-11 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.003978 Informative Inherited
Biological Process (BP) hemostasis 6.053e-11 Highly Informative Direct
Biological Process (BP) wound healing 5.484e-09 Highly Informative Direct
Biological Process (BP) coagulation 8.413e-08 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.0735 Highly Informative Inherited
Molecular Function (MF) transferase activity 2.268e-09 Least Informative Direct
Molecular Function (MF) binding 0.5837 Least Informative Inherited
Molecular Function (MF) cation binding 0.2376 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 4.571e-15 Informative Direct
Molecular Function (MF) calcium ion binding 2.854e-07 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.2992 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.004348 Least Informative Inherited
Cellular Component (CC) cytoskeleton 4.039e-06 Moderately Informative Direct
Cellular Component (CC) cell cortex 7.106e-07 Informative Direct
Cellular Component (CC) cortical cytoskeleton 3.538e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.00608Least InformativeInherited
Disease Ontology (DO)skin disease2.633e-05Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.01666Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis3.127e-09InformativeDirect

Document: DO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
DiseaseDisease mutation4.745e-08Least InformativeDirect
Molecular functionMetal-binding1.154e-15Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationZymogen6.224e-06InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008958 SSF49309 Protein matches
Abstract

Synonym(s): Protein-glutamine gamma-glutamyltransferase, Fibrinoligase, TGase

Transglutaminases catalyse the post-translational modification of proteins at glutamine residues, with formation of isopeptide bonds. Members of the transglutaminase family usually have three domains: N-terminal , middle and C-terminal. The middle domain is usually well conserved, but family members can display major differences in their N- and C-terminal domains, although their overall structure is conserved [PubMed10411627]. This entry represents the C-terminal domain found in transglutaminases, which consists of an immunoglobulin-like beta-sandwich consisting of seven strands in two sheets with a Greek key topology.

The best known transglutaminase is blood coagulation factor XIII, a plasma tetrameric protein composed of two catalytic A subunits and two non-catalytic B subunits. Factor XIII is responsible for cross-linking fibrin chains, thus stabilizing the fibrin clot. Protein-glutamine gamma-glutamyltransferases are calcium-dependent enzymes that catalyse the cross-linking of proteins by promoting the formation of isopeptide bonds between the gamma-carboxyl group of a glutamine in one polypeptide chain and the epsilon-amino group of a lysine in a second polypeptide chain. TGases also catalyse the conjugation of polyamines to proteins [PubMed1683845, PubMed1974250].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transglutaminase, two C-terminal domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Transglutaminase, two C-terminal domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]