SUPERFAMILY 1.75 HMM library and genome assignments server


Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)


Superfamily statistics
Genomes (1,726) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 70,132 91,738 172
Proteins 29,140 47,558 117


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process5.075e-073.362e-06Least InformativeDirect
Biological Process (BP)multicellular organismal process7.87e-050Least InformativeDirect
Biological Process (BP)response to stimulus0.00026780Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00028870Least InformativeDirect
Biological Process (BP)developmental process0.001330Least InformativeInherited
Biological Process (BP)localization0.053611.576e-10Least InformativeInherited
Biological Process (BP)cell differentiation9.595e-068.629e-10Moderately InformativeDirect
Biological Process (BP)reproduction2.973e-050.0003795Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.00082860Moderately InformativeDirect
Biological Process (BP)tissue development0.0014911Moderately InformativeInherited
Biological Process (BP)organ development0.04810.02817Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.057041Moderately InformativeInherited
Biological Process (BP)response to organic substance5.685e-081Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00011450.3363Moderately InformativeInherited
Biological Process (BP)signal transduction0.0015710Moderately InformativeInherited
Biological Process (BP)response to cytokine stimulus1.74e-140InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00021733.13e-13InformativeDirect
Biological Process (BP)growth0.00046620InformativeDirect
Biological Process (BP)gland development1.331e-060.4694InformativeInherited
Biological Process (BP)epithelium development2.173e-070.5196InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.00016150.006195InformativeInherited
Biological Process (BP)response to hormone stimulus0.44271InformativeInherited
Biological Process (BP)reproductive system development2.704e-051InformativeInherited
Biological Process (BP)developmental process involved in reproduction7.559e-051InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.041130.001685InformativeInherited
Biological Process (BP)intracellular signal transduction0.41831InformativeInherited
Biological Process (BP)cytokine-mediated signaling pathway00Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development8.741e-080.0004943Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion1.28e-050Highly InformativeDirect
Biological Process (BP)lactation2.828e-058.694e-05Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development0.00019990.0002837Highly InformativeDirect
Biological Process (BP)developmental growth0.00027151.425e-09Highly InformativeDirect
Biological Process (BP)hormone-mediated signaling pathway0.0021791Highly InformativeInherited
Molecular Function (MF)binding0.0048520Least InformativeInherited
Molecular Function (MF)receptor activity9.122e-100InformativeDirect
Molecular Function (MF)molecular transducer activity1.894e-090InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 3.362e-06 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) localization 1.576e-10 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cell differentiation 8.629e-10 Moderately Informative Direct
Biological Process (BP) reproduction 0.0003795 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 3.358e-10 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.023e-13 Moderately Informative Direct
Biological Process (BP) system process 6.012e-06 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.572e-05 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8175 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.02817 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1972 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3363 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.3853 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.482 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 3.13e-13 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) regulation of nervous system development 3.969e-14 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 9.921e-14 Informative Direct
Biological Process (BP) vesicle-mediated transport 4.048e-13 Informative Direct
Biological Process (BP) regulation of cell development 5.566e-13 Informative Direct
Biological Process (BP) positive regulation of developmental process 3.627e-12 Informative Direct
Biological Process (BP) phosphorylation 2.221e-11 Informative Direct
Biological Process (BP) blood circulation 8.43e-10 Informative Direct
Biological Process (BP) response to other organism 2.86e-08 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 2.951e-08 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 1.742e-07 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 2.784e-07 Informative Direct
Biological Process (BP) defense response 4.768e-07 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 1.092e-06 Informative Direct
Biological Process (BP) cytoskeleton organization 3.587e-06 Informative Direct
Biological Process (BP) regulation of locomotion 3.843e-06 Informative Direct
Biological Process (BP) regulation of cellular component movement 8.544e-06 Informative Direct
Biological Process (BP) organelle assembly 1.482e-05 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 1.558e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 2.564e-05 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 5.394e-05 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0002745 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0004258 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.0008847 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.5495 Informative Inherited
Biological Process (BP) epithelium development 0.5196 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.006195 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.8923 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) gland development 0.4694 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.7101 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.9767 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.5189 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.741 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.01388 Informative Inherited
Biological Process (BP) sensory organ development 0.9757 Informative Inherited
Biological Process (BP) organ morphogenesis 0.536 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1858 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.608 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.566 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.5359 Informative Inherited
Biological Process (BP) regulation of growth 0.2327 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.3565 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.8133 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.001635 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.01009 Informative Inherited
Biological Process (BP) immune response 0.8696 Informative Inherited
Biological Process (BP) immune effector process 0.03718 Informative Inherited
Biological Process (BP) secondary metabolic process 0.6538 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.002588 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.00877 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.0433 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.001324 Informative Inherited
Biological Process (BP) protein complex assembly 0.3746 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.03762 Informative Inherited
Biological Process (BP) muscle structure development 0.02136 Informative Inherited
Biological Process (BP) leukocyte activation 0.1013 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9259 Informative Inherited
Biological Process (BP) muscle tissue development 0.04556 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.8928 Informative Inherited
Biological Process (BP) sexual reproduction 0.1172 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.001685 Informative Inherited
Biological Process (BP) single organism reproductive process 0.7571 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2161 Informative Inherited
Biological Process (BP) muscle system process 0.1463 Informative Inherited
Biological Process (BP) apoptotic process 0.01054 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.7474 Informative Inherited
Biological Process (BP) pigment metabolic process 0.0467 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.393 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.003904 Informative Inherited
Biological Process (BP) regulation of immune response 0.9432 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.8834 Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 0.0004943 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) lactation 8.694e-05 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0002837 Highly Informative Direct
Biological Process (BP) developmental growth 1.425e-09 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) axon development 0 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 1.269e-14 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 1.675e-13 Highly Informative Direct
Biological Process (BP) cell junction organization 1.797e-13 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 2.812e-12 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 1.078e-11 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 5.39e-11 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 8.506e-10 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 3.566e-09 Highly Informative Direct
Biological Process (BP) spermatogenesis 4.259e-09 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 5.021e-09 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 1.155e-07 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 1.236e-07 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1.892e-07 Highly Informative Direct
Biological Process (BP) eye morphogenesis 4.403e-07 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 4.65e-07 Highly Informative Direct
Biological Process (BP) regulation of cell killing 1.3e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 2.611e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 4.263e-06 Highly Informative Direct
Biological Process (BP) cellular response to peptide 6.791e-06 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 1.33e-05 Highly Informative Direct
Biological Process (BP) coagulation 1.934e-05 Highly Informative Direct
Biological Process (BP) regulation of cell size 2.278e-05 Highly Informative Direct
Biological Process (BP) sensory perception 8.246e-05 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0001181 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response 0.0001878 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.0001896 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0.0002917 Highly Informative Direct
Biological Process (BP) learning or memory 0.0007394 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0008589 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.3285 Highly Informative Inherited
Biological Process (BP) positive regulation of endopeptidase activity 0.4121 Highly Informative Inherited
Biological Process (BP) renal system development 0.5711 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.001269 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.88 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 1 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.5198 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.1904 Highly Informative Inherited
Biological Process (BP) response to virus 0.08514 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.001614 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.08125 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.2432 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.06035 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.3089 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.001837 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.003571 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.348 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.2717 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.005917 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.1478 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.6353 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.854 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.4966 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.04095 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.08582 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.7272 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.001844 Highly Informative Inherited
Biological Process (BP) B cell activation 0.2944 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.002306 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.04104 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphorylation 0.05465 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.08768 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.8472 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.01106 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.0111 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.8005 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.003596 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 1 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.04046 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.9399 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.3476 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 1 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.001933 Highly Informative Inherited
Biological Process (BP) protein glycosylation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.08816 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.001603 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.1225 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.01075 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.03199 Highly Informative Inherited
Biological Process (BP) protein processing 0.1841 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.3312 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.1122 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.9338 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 4.265e-09 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.6863 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 2.903e-14 Informative Direct
Molecular Function (MF) peptidase regulator activity 1.121e-05 Informative Direct
Molecular Function (MF) amide binding 0.02755 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.9686 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.009102 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) receptor binding 0.8626 Informative Inherited
Molecular Function (MF) antigen binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 3.122e-07 Highly Informative Direct
Molecular Function (MF) peptide binding 1.327e-05 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0001966 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.1378 Highly Informative Inherited
Molecular Function (MF) UDP-glycosyltransferase activity 0.002513 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.04773 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.3032 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.243 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 4.242e-09 Moderately Informative Direct
Cellular Component (CC) vesicle 0.02215 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.007474 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 2.162e-12 Informative Direct
Cellular Component (CC) cell leading edge 6.003e-09 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 1.451e-06 Informative Direct
Cellular Component (CC) endosome 6.419e-06 Informative Direct
Cellular Component (CC) integral to membrane 0.0002507 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 4.39e-13 Highly Informative Direct
Cellular Component (CC) receptor complex 6.061e-10 Highly Informative Direct
Cellular Component (CC) dendrite 3.93e-07 Highly Informative Direct
Cellular Component (CC) endosomal part 0.0001233 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 0.0003316 Highly Informative Direct
Cellular Component (CC) sarcomere 0.0257 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.1032 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds7.826e-15Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl4.277e-11Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)urinary system disease0.2307Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.5554Moderately InformativeInherited
Disease Ontology (DO)cardiomyopathy0.0005553InformativeDirect
Disease Ontology (DO)kidney failure0.02291InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.676InformativeInherited
Disease Ontology (DO)acute kidney failure2.682e-06Highly InformativeDirect
Disease Ontology (DO)leprosy0.0297Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.09858Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.04095Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3241Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.683Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.7452Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8351Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.006326Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.01138Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.22Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.251Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2628Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8816Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level1.148e-05InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.01302InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.05562InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1209InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.3396InformativeInherited
Mammalian Phenotype (MP)abnormal placenta morphology0.6117InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.6399InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.000463Highly InformativeDirect
Mammalian Phenotype (MP)abnormal uterus morphology0.007623Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vagina morphology0.04514Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spermiogenesis0.05728Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.02119Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.0997Least InformativeInherited
Worm Phenotype (WP)growth variant0.7352Least InformativeInherited
Worm Phenotype (WP)organ system development variant3.815e-07Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.007356Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.00995Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant1.004e-10InformativeDirect
Worm Phenotype (WP)neuron development variant5.758e-07InformativeDirect
Worm Phenotype (WP)cell migration variant0.0005568InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant0.001963InformativeInherited
Worm Phenotype (WP)activity level variant0.01276InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.01636InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.04595InformativeInherited
Worm Phenotype (WP)organism stress response variant0.647InformativeInherited
Worm Phenotype (WP)muscle arm development defective7.638e-09Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant2.387e-08Highly InformativeDirect
Worm Phenotype (WP)myopodia present5.88e-06Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0001454Highly InformativeDirect
Worm Phenotype (WP)roller0.0001569Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0008138Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE0.0009604Highly InformativeDirect
Worm Phenotype (WP)axon development variant0.5179Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell adhesion defective0.0001619Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision3.163e-05Least InformativeDirect
Fly Anatomy (FA)anatomical group0.000207Least InformativeDirect
Fly Anatomy (FA)organ system0.002996Least InformativeInherited
Fly Anatomy (FA)larva0.02094Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.02954Least InformativeInherited
Fly Anatomy (FA)cell0.4087Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure2.57e-08Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.02633Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.02917Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.03377Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.05477Moderately InformativeInherited
Fly Anatomy (FA)neuron0.0893Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.0989Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.1008Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.208Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.5335Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.7601Moderately InformativeInherited
Fly Anatomy (FA)head0.8564Moderately InformativeInherited
Fly Anatomy (FA)appendage0.8984Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.9504Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment1Moderately InformativeInherited
Fly Anatomy (FA)commissure2.471e-07InformativeDirect
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.0009918InformativeDirect
Fly Anatomy (FA)adult brain0.002036InformativeInherited
Fly Anatomy (FA)chemosensory system0.00883InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion0.05088InformativeInherited
Fly Anatomy (FA)chaeta0.05291InformativeInherited
Fly Anatomy (FA)sensory organ cell0.08165InformativeInherited
Fly Anatomy (FA)leg0.298InformativeInherited
Fly Anatomy (FA)ipsilateral tract0.7404InformativeInherited
Fly Anatomy (FA)prothoracic leg taste bristle0.0004253Highly InformativeDirect
Fly Anatomy (FA)chemosensory neuron0.004757Highly InformativeInherited
Fly Anatomy (FA)eo neuron0.08534Highly InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage6.371e-05Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage7.828e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases4.336e-07Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases1.95e-05Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1712Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Chitinase0.0003984Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.1739Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processHemostasis2.318e-06InformativeDirect
Biological processPolysaccharide degradation0.0001071InformativeDirect
Biological processChemotaxis0.0003301InformativeDirect
Biological processAcute phase1.612e-12Highly InformativeDirect
Biological processNotch signaling pathway1.249e-08Highly InformativeDirect
Biological processBlood coagulation2.197e-06Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoskeleton1.047e-07Moderately InformativeDirect
Cellular componentEndosome4.674e-05Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
Coding sequence diversityAlternative splicing3.086e-05Least InformativeDirect
DiseaseDisease mutation9.063e-06Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainEGF-like domain9.229e-16InformativeDirect
DomainLeucine-rich repeat7.925e-12InformativeDirect
DomainCollagen5.925e-09Highly InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionCalmodulin-binding1.837e-06InformativeDirect
Molecular functionActin-binding1.34e-05InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationMetalloprotease0.0007041InformativeDirect
Post-translational modificationGlycosidase0.0009794InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationCytokine1.762e-15Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0.0008933InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism6.755e-16Least InformativeDirect
UniPathway (UP)protein glycosylation4.61e-09InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches
Abstract

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 111 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 111 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]