SUPERFAMILY 1.75 HMM library and genome assignments server


Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)


Superfamily statistics
Genomes (1,727) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 70,136 91,738 172
Proteins 29,144 47,558 117


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process5.674e-072.747e-06Least InformativeDirect
Biological Process (BP)multicellular organismal process8.006e-050Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0002760Least InformativeDirect
Biological Process (BP)response to stimulus0.00029710Least InformativeDirect
Biological Process (BP)developmental process0.0013530Least InformativeInherited
Biological Process (BP)localization0.054913.354e-10Least InformativeInherited
Biological Process (BP)cell differentiation9.8e-068.344e-10Moderately InformativeDirect
Biological Process (BP)reproduction3.037e-050.0004689Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.00081490Moderately InformativeDirect
Biological Process (BP)tissue development0.0014761Moderately InformativeInherited
Biological Process (BP)organ development0.048350.03146Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.4660.4856Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.15870Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.056881Moderately InformativeInherited
Biological Process (BP)response to organic substance6.316e-081Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00011020.3427Moderately InformativeInherited
Biological Process (BP)signal transduction0.0015510Moderately InformativeInherited
Biological Process (BP)response to cytokine stimulus2.449e-140InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00021412.637e-13InformativeDirect
Biological Process (BP)growth0.00051080InformativeDirect
Biological Process (BP)gland development1.333e-060.4512InformativeInherited
Biological Process (BP)epithelium development2.205e-070.5203InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.00017140.008373InformativeInherited
Biological Process (BP)response to hormone stimulus0.43651InformativeInherited
Biological Process (BP)reproductive system development2.704e-051InformativeInherited
Biological Process (BP)developmental process involved in reproduction7.413e-051InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.041490.001673InformativeInherited
Biological Process (BP)intracellular signal transduction0.40361InformativeInherited
Biological Process (BP)cytokine-mediated signaling pathway00Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development8.715e-080.0004914Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion1.335e-050Highly InformativeDirect
Biological Process (BP)lactation2.815e-058.824e-05Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development0.0002010.0002876Highly InformativeDirect
Biological Process (BP)developmental growth0.00027241.593e-09Highly InformativeDirect
Biological Process (BP)hormone-mediated signaling pathway0.0021481Highly InformativeInherited
Molecular Function (MF)binding0.0055310Least InformativeInherited
Molecular Function (MF)receptor activity9.229e-100InformativeDirect
Molecular Function (MF)molecular transducer activity1.921e-090InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 2.747e-06 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) localization 3.354e-10 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cell differentiation 8.344e-10 Moderately Informative Direct
Biological Process (BP) reproduction 0.0004689 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 2.346e-10 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.021e-12 Moderately Informative Direct
Biological Process (BP) system process 5.329e-06 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 4.199e-05 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7807 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.4856 Moderately Informative Inherited
Biological Process (BP) organ development 0.03146 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2338 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3427 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.5355 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 2.637e-13 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) dephosphorylation 1.083e-14 Informative Direct
Biological Process (BP) regulation of nervous system development 1.772e-14 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 1.237e-13 Informative Direct
Biological Process (BP) regulation of cell development 2.078e-13 Informative Direct
Biological Process (BP) vesicle-mediated transport 9.06e-13 Informative Direct
Biological Process (BP) positive regulation of developmental process 3.73e-12 Informative Direct
Biological Process (BP) phosphorylation 4.14e-12 Informative Direct
Biological Process (BP) blood circulation 1.065e-09 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 2.479e-08 Informative Direct
Biological Process (BP) response to other organism 3.697e-08 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 1.733e-07 Informative Direct
Biological Process (BP) defense response 6.202e-07 Informative Direct
Biological Process (BP) regulation of locomotion 1.787e-06 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 2.22e-06 Informative Direct
Biological Process (BP) regulation of cellular component movement 4.148e-06 Informative Direct
Biological Process (BP) cytoskeleton organization 4.279e-06 Informative Direct
Biological Process (BP) organelle assembly 1.511e-05 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 1.529e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 4.47e-05 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 9.162e-05 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0001203 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0004468 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.0006584 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.5413 Informative Inherited
Biological Process (BP) epithelium development 0.5203 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.008373 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.892 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) gland development 0.4512 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.5645 Informative Inherited
Biological Process (BP) protein oligomerization 0.09858 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.7307 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.01602 Informative Inherited
Biological Process (BP) sensory organ development 0.9619 Informative Inherited
Biological Process (BP) organ morphogenesis 0.5141 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1715 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.6153 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.5704 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.5483 Informative Inherited
Biological Process (BP) regulation of growth 0.2342 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.4092 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.8122 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.001731 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.01266 Informative Inherited
Biological Process (BP) immune response 0.845 Informative Inherited
Biological Process (BP) immune effector process 0.04721 Informative Inherited
Biological Process (BP) secondary metabolic process 0.6711 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.002364 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.00804 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.0584 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.001604 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.03667 Informative Inherited
Biological Process (BP) muscle structure development 0.02057 Informative Inherited
Biological Process (BP) leukocyte activation 0.1306 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9099 Informative Inherited
Biological Process (BP) muscle tissue development 0.0455 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.9055 Informative Inherited
Biological Process (BP) sexual reproduction 0.1108 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.001673 Informative Inherited
Biological Process (BP) single organism reproductive process 0.7389 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2105 Informative Inherited
Biological Process (BP) muscle system process 0.1577 Informative Inherited
Biological Process (BP) apoptotic process 0.0122 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.7589 Informative Inherited
Biological Process (BP) pigment metabolic process 0.04568 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.8573 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.4132 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.005922 Informative Inherited
Biological Process (BP) regulation of immune response 0.9781 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.9315 Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 0.0004914 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) lactation 8.824e-05 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0002876 Highly Informative Direct
Biological Process (BP) developmental growth 1.593e-09 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 1.429e-14 Highly Informative Direct
Biological Process (BP) cell junction organization 1.454e-13 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 2.561e-11 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 3.592e-11 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 6.467e-11 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 7.828e-10 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 4.339e-09 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 4.538e-09 Highly Informative Direct
Biological Process (BP) spermatogenesis 5.804e-09 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 1.622e-08 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 3.604e-08 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 8.528e-08 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1.919e-07 Highly Informative Direct
Biological Process (BP) eye morphogenesis 3.413e-07 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 3.49e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 8.295e-07 Highly Informative Direct
Biological Process (BP) cellular response to peptide 6.342e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 9.744e-06 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 1.001e-05 Highly Informative Direct
Biological Process (BP) regulation of cell size 1.948e-05 Highly Informative Direct
Biological Process (BP) coagulation 1.992e-05 Highly Informative Direct
Biological Process (BP) sensory perception 8.254e-05 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0001359 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.0002182 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response 0.000466 Highly Informative Direct
Biological Process (BP) learning or memory 0.0005476 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0.0007654 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0009297 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0.3994 Highly Informative Inherited
Biological Process (BP) renal system development 0.5668 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.001249 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.8969 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 1 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.5225 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.1982 Highly Informative Inherited
Biological Process (BP) response to virus 0.1011 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.002103 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.08828 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.2653 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.07775 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.4343 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.003772 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.338 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.2301 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.006097 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.1214 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.6149 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.8449 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.5809 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.04224 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.07348 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.7779 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.001456 Highly Informative Inherited
Biological Process (BP) B cell activation 0.3841 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.002197 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.003566 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.04038 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphorylation 0.06515 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.1068 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.8449 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.01139 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.01259 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.8162 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.003396 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 1 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.03776 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.64 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.3318 Highly Informative Inherited
Biological Process (BP) respiratory system development 1 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.002183 Highly Informative Inherited
Biological Process (BP) protein glycosylation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.08399 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.001529 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.2145 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.01026 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.02783 Highly Informative Inherited
Biological Process (BP) protein processing 0.1865 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.3528 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated cytotoxicity 0.003239 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.186 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.9471 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1.752e-08 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.7092 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 2.112e-14 Informative Direct
Molecular Function (MF) peptidase regulator activity 1.251e-05 Informative Direct
Molecular Function (MF) amide binding 0.02646 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.9628 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.01051 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) receptor binding 0.8602 Informative Inherited
Molecular Function (MF) antigen binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 2.817e-07 Highly Informative Direct
Molecular Function (MF) peptide binding 1.46e-05 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0002082 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.1319 Highly Informative Inherited
Molecular Function (MF) UDP-glycosyltransferase activity 0.002783 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.05368 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.3033 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.2549 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1.011e-09 Moderately Informative Direct
Cellular Component (CC) vesicle 0.02595 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.00864 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 1.331e-12 Informative Direct
Cellular Component (CC) cell leading edge 6.769e-09 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 1.748e-06 Informative Direct
Cellular Component (CC) endosome 9.052e-06 Informative Direct
Cellular Component (CC) integral to membrane 0.000216 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 9.4e-13 Highly Informative Direct
Cellular Component (CC) receptor complex 6.987e-10 Highly Informative Direct
Cellular Component (CC) dendrite 2.8e-07 Highly Informative Direct
Cellular Component (CC) endosomal part 0.0001302 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 0.0003527 Highly Informative Direct
Cellular Component (CC) sarcomere 0.02561 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds7.826e-15Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl4.277e-11Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.6308Least InformativeInherited
Disease Ontology (DO)urinary system disease0.2238Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.4723Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.5268Moderately InformativeInherited
Disease Ontology (DO)kidney failure0.07234InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.6846InformativeInherited
Disease Ontology (DO)acute kidney failure1.015e-05Highly InformativeDirect
Disease Ontology (DO)leprosy0.03009Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.1113Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.04067Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3272Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.683Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.7716Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8348Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.006682Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.01174Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.2147Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2535Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2638Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8798Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level1.247e-05InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.01264InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.05573InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1224InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.3411InformativeInherited
Mammalian Phenotype (MP)abnormal placenta morphology0.6059InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.6411InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0004656Highly InformativeDirect
Mammalian Phenotype (MP)abnormal uterus morphology0.007895Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vagina morphology0.04468Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spermiogenesis0.05692Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.02119Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.0997Least InformativeInherited
Worm Phenotype (WP)growth variant0.7352Least InformativeInherited
Worm Phenotype (WP)organ system development variant3.815e-07Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.007356Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.00995Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant1.004e-10InformativeDirect
Worm Phenotype (WP)neuron development variant5.758e-07InformativeDirect
Worm Phenotype (WP)cell migration variant0.0005568InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant0.001963InformativeInherited
Worm Phenotype (WP)activity level variant0.01276InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.01636InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.04595InformativeInherited
Worm Phenotype (WP)organism stress response variant0.647InformativeInherited
Worm Phenotype (WP)muscle arm development defective7.638e-09Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant2.387e-08Highly InformativeDirect
Worm Phenotype (WP)myopodia present5.88e-06Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0001454Highly InformativeDirect
Worm Phenotype (WP)roller0.0001569Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0008138Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE0.0009604Highly InformativeDirect
Worm Phenotype (WP)axon development variant0.5179Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell adhesion defective0.0001608Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision2.913e-05Least InformativeDirect
Fly Anatomy (FA)anatomical group0.000178Least InformativeDirect
Fly Anatomy (FA)organ system0.002857Least InformativeInherited
Fly Anatomy (FA)adult0.01463Least InformativeInherited
Fly Anatomy (FA)larva0.02122Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.03066Least InformativeInherited
Fly Anatomy (FA)cell0.395Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure2.827e-08Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.02559Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.028Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.03094Moderately InformativeInherited
Fly Anatomy (FA)neuron0.07812Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.1001Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.1311Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2103Moderately InformativeInherited
Fly Anatomy (FA)adult head0.3603Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.5227Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.5878Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.6551Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.7602Moderately InformativeInherited
Fly Anatomy (FA)appendage0.9003Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.9449Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment1Moderately InformativeInherited
Fly Anatomy (FA)commissure2.571e-07InformativeDirect
Fly Anatomy (FA)adult brain0.002182InformativeInherited
Fly Anatomy (FA)chemosensory system0.009964InformativeInherited
Fly Anatomy (FA)chaeta0.05152InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion0.05331InformativeInherited
Fly Anatomy (FA)sensory organ cell0.08008InformativeInherited
Fly Anatomy (FA)leg0.298InformativeInherited
Fly Anatomy (FA)ipsilateral tract0.735InformativeInherited
Fly Anatomy (FA)prothoracic leg taste bristle0.0004182Highly InformativeDirect
Fly Anatomy (FA)chemosensory neuron0.005291Highly InformativeInherited
Fly Anatomy (FA)eo neuron0.07907Highly InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0.4367Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4811Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.0001282InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage3.267e-05Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage4.008e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases5.126e-07Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases1.825e-05Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1714Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Chitinase0.0003977Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.1739Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processHemostasis2.318e-06InformativeDirect
Biological processPolysaccharide degradation0.0001071InformativeDirect
Biological processChemotaxis0.0003301InformativeDirect
Biological processAcute phase1.612e-12Highly InformativeDirect
Biological processNotch signaling pathway1.249e-08Highly InformativeDirect
Biological processBlood coagulation2.197e-06Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoskeleton1.047e-07Moderately InformativeDirect
Cellular componentEndosome4.674e-05Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
Coding sequence diversityAlternative splicing3.086e-05Least InformativeDirect
DiseaseDisease mutation9.063e-06Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainEGF-like domain9.229e-16InformativeDirect
DomainLeucine-rich repeat7.925e-12InformativeDirect
DomainCollagen5.925e-09Highly InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionCalmodulin-binding1.837e-06InformativeDirect
Molecular functionActin-binding1.34e-05InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationMetalloprotease0.0007041InformativeDirect
Post-translational modificationGlycosidase0.0009794InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationCytokine1.762e-15Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0.0008933InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches
Abstract

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 111 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 111 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]