SUPERFAMILY 1.75 HMM library and genome assignments server

Multiheme cytochromes superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Multiheme cytochromes [ 48694]
Superfamily:   Multiheme cytochromes [ 48695] (3)
Families:   Cytochrome c3-like [ 48696] (4)
  Photosynthetic reaction centre (cytochrome subunit) [ 48707]
  Di-heme elbow motif [ 48711] (7)


Superfamily statistics
Genomes (1,198) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,686 31,731 58
Proteins 5,911 30,728 58


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.38910.02954Least InformativeInherited
Biological Process (BP)single-organism cellular process0.64320.9766Least InformativeInherited
Biological Process (BP)oxidation-reduction process0.00016560.0000000003171Moderately InformativeDirect
Biological Process (BP)energy derivation by oxidation of organic compounds0.000001650.0000000000003276InformativeDirect
Molecular Function (MF)oxidoreductase activity0.00049380.0004307Moderately InformativeDirect
Molecular Function (MF)electron carrier activity0.00000039640InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.9766 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.02954 Least Informative Inherited
Biological Process (BP) oxidation-reduction process 0.0000000003171 Moderately Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.0000000000003276 Informative Direct
Biological Process (BP) electron transport chain 0.00000001428 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity 0.0004307 Moderately Informative Direct
Molecular Function (MF) electron carrier activity 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With a quinone or related compound as acceptor0.0000004378Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processElectron transport0InformativeDirect
Cellular componentPeriplasm0InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)nitrate reduction0InformativeDirect
UniPathway (UP)nitrate reduction (assimilation)0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Multiheme cytochromes domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the Multiheme cytochromes superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]