SUPERFAMILY 1.75 HMM library and genome assignments server


Epsilon subunit of mitochondrial F1F0-ATP synthase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Non-globular all-alpha subunits of globular proteins [ 48661] (14)
Superfamily:   Epsilon subunit of mitochondrial F1F0-ATP synthase [ 48690]
Families:   Epsilon subunit of mitochondrial F1F0-ATP synthase [ 48691]


Superfamily statistics
Genomes (371) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 480 383 1
Proteins 480 383 1


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)membrane4.826e-050.0001716Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle1.486e-062.716e-05Least InformativeDirect
Cellular Component (CC)protein complex6.202e-050.0004574Least InformativeDirect
Cellular Component (CC)cytoplasmic part1.903e-062.291e-06Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.0031030.009021Least InformativeInherited
Cellular Component (CC)organelle membrane1.254e-061.506e-07Moderately InformativeDirect
Cellular Component (CC)organelle envelope3.115e-079.948e-09Moderately InformativeDirect
Cellular Component (CC)mitochondrial part1.109e-075.441e-09Moderately InformativeDirect
Cellular Component (CC)proton-transporting two-sector ATPase complex1.784e-140InformativeDirect
Cellular Component (CC)mitochondrial membrane part6.976e-071.295e-08InformativeDirect
Cellular Component (CC)mitochondrial proton-transporting ATP synthase complex4.107e-056.31e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Cellular Component (CC) membrane 0.0001716 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 2.716e-05 Least Informative Direct
Cellular Component (CC) protein complex 0.0004574 Least Informative Direct
Cellular Component (CC) cytoplasmic part 2.291e-06 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.009021 Least Informative Inherited
Cellular Component (CC) organelle membrane 1.506e-07 Moderately Informative Direct
Cellular Component (CC) organelle envelope 9.948e-09 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 5.441e-09 Moderately Informative Direct
Cellular Component (CC) proton-transporting two-sector ATPase complex 0 Informative Direct
Cellular Component (CC) mitochondrial membrane part 1.295e-08 Informative Direct
Cellular Component (CC) mitochondrial proton-transporting ATP synthase complex 6.31e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect

Document: WP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processATP synthesis0Highly InformativeDirect
Biological processHydrogen ion transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion inner membrane0InformativeDirect
Cellular componentCF(1)0Highly InformativeDirect
Post-translational modificationHydrolase0.0007445Least InformativeDirect
Post-translational modificationAcetylation5.329e-05Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006721 SSF48690 Protein matches
Abstract

This family constitutes the mitochondrial ATP synthase epsilon subunit, which is distinct from the bacterial epsilon subunit (the latter being homologous to the mitochondrial delta subunit, ). The mitochondrial epsilon subunit is located in the stalk region of the F1 complex, and acts as an inhibitor of the ATPase catalytic core. The epsilon subunit can assume two conformations, contracted and extended, where the latter inhibits ATP hydrolysis. The conformation of the epsilon subunit is determined by the direction of rotation of the gamma subunit, and possibly by the presence of ADP. The extended epsilon subunit is thought to become extended in the presence of ADP, thereby acting as a safety lock to prevent wasteful ATP hydrolysis [PubMed16154570].

More information about this protein can be found at Protein of the Month: ATP Synthases.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Epsilon subunit of mitochondrial F1F0-ATP synthase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Epsilon subunit of mitochondrial F1F0-ATP synthase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · UniProtKB KeyWords (KW) · Internal database links ]