SUPERFAMILY 1.75 HMM library and genome assignments server


Moesin tail domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Non-globular all-alpha subunits of globular proteins [ 48661] (14)
Superfamily:   Moesin tail domain [ 48678]
Families:   Moesin tail domain [ 48679]


Superfamily statistics
Genomes (140) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 628 684 1
Proteins 627 683 1


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 1.465e-10 Least Informative Direct
Biological Process (BP) single-organism cellular process 6.345e-08 Least Informative Direct
Biological Process (BP) localization 1.916e-06 Least Informative Direct
Biological Process (BP) developmental process 0.001965 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.7127 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.5206 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.7877 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.07232 Least Informative Inherited
Biological Process (BP) tissue development 3.133e-05 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0001453 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0002159 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.04928 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.5689 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.001198 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1622 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.006615 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.004873 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.08696 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.01254 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.003853 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01144 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.1631 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 3.742e-09 Informative Direct
Biological Process (BP) actin filament-based process 4.723e-07 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 3.825e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 6.345e-05 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0001252 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0002357 Informative Direct
Biological Process (BP) regulation of organelle organization 0.001038 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.001602 Informative Inherited
Biological Process (BP) cell projection organization 0.006934 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.004037 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.004926 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.006409 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.008635 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.01144 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 9.865e-11 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 6.295e-07 Highly Informative Direct
Biological Process (BP) actin filament organization 3.979e-06 Highly Informative Direct
Biological Process (BP) cell projection assembly 4.89e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0002591 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0005597 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0008118 Highly Informative Direct
Molecular Function (MF) binding 3.515e-11 Least Informative Direct
Molecular Function (MF) cytoskeletal protein binding 9.496e-11 Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 2.998e-12 Least Informative Direct
Cellular Component (CC) membrane 4.314e-08 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0007512 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.9554 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.004062 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 2.049e-08 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0002513 Moderately Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell leading edge 3.015e-11 Informative Direct
Cellular Component (CC) cell cortex 7.547e-09 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.002445 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) cell division site part 6.059e-13 Highly Informative Direct
Cellular Component (CC) cilium part 6.683e-07 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 9.164e-05 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0001089 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0002763 Highly Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)oviduct0InformativeDirect
Xenopus ANatomical entity (XAN)stomach0Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell shape4.38e-06InformativeDirect
Cellular componentMembrane6.113e-13Least InformativeDirect
Cellular componentCytoplasm5.088e-09Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell membrane2.156e-08Moderately InformativeDirect
Cellular componentCell junction2.888e-08Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationActin capping6.336e-15Highly InformativeDirect
Post-translational modificationPhosphoprotein1.926e-13Least InformativeDirect
Post-translational modificationAcetylation7.303e-05Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008954 SSF48678 Protein matches
Abstract

ERM proteins, highly related members of the larger protein 4.1 superfamily, can exist in an active or inactive conformation. The sole Drosophila ERM protein, Moesin, functions to promote cortical actin assembly and apical-basal polarity. As a result, cells lacking Moesin lose epithelial characteristics and adopt invasive migratory behaviour. Moesin appears to facilitate epithelial morphology not by providing an essential structural function, but rather by antagonizing activity of the small GTPase Rho. Thus, Moesin functions in maintaining epithelial integrity by regulating cell-signalling events that affect actin organization and polarity [PubMed12511959].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Moesin tail domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Moesin tail domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]