SUPERFAMILY 1.75 HMM library and genome assignments server

Moesin tail domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Non-globular all-alpha subunits of globular proteins [ 48661] (14)
Superfamily:   Moesin tail domain [ 48678]
Families:   Moesin tail domain [ 48679]


Superfamily statistics
Genomes (140) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 628 684 1
Proteins 627 683 1


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.000004852 Least Informative Direct
Biological Process (BP) localization 0.0000005341 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000000263 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.58 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.7547 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.5949 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.001967 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.0544 Least Informative Inherited
Biological Process (BP) tissue development 0.0002713 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0002131 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0001994 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.01335 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2943 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01153 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2621 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.006334 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.07773 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.001242 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.00892 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.01196 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.00256 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.00004353 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000000379 Informative Direct
Biological Process (BP) actin filament-based process 0.0000001282 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0001896 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0002326 Informative Direct
Biological Process (BP) tissue morphogenesis 0.000036 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.008152 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.005158 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01124 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.001452 Informative Inherited
Biological Process (BP) cell projection organization 0.002901 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.01012 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.001657 Informative Inherited
Biological Process (BP) negative regulation of protein phosphorylation 0.0004133 Highly Informative Direct
Biological Process (BP) actin filament organization 0.000001664 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00000000002552 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000216 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.00004857 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.0000006232 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0001595 Highly Informative Direct
Molecular Function (MF) binding 0.00000000004652 Least Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.00000000008802 Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0000002412 Highly Informative Direct
Cellular Component (CC) membrane 0.000000007953 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0000000001896 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0006258 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.9704 Least Informative Inherited
Cellular Component (CC) protein complex 0.00383 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0002433 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.0000000007105 Moderately Informative Direct
Cellular Component (CC) membrane region 0.00000005983 Moderately Informative Direct
Cellular Component (CC) cell cortex 0.000000007636 Informative Direct
Cellular Component (CC) cell surface 0.000003141 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell leading edge 0.00000000002872 Informative Direct
Cellular Component (CC) plasma membrane region 0.00000000003865 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.001727 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.000001028 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0000000002609 Highly Informative Direct
Cellular Component (CC) cell division site part 0.0000000000006152 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0001179 Highly Informative Direct
Cellular Component (CC) ciliary part 0.00002218 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.2224 Highly Informative Inherited

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)oviduct0InformativeDirect
Xenopus ANatomical entity (XAN)stomach0Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell shape0.000004381InformativeDirect
Cellular componentMembrane0.0000000000006314Least InformativeDirect
Cellular componentCytoplasm0.000000005055Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell membrane0.00000002281Moderately InformativeDirect
Cellular componentCell junction0.00000002905Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationActin capping0.000000000000006341Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0000000000001997Least InformativeDirect
Post-translational modificationAcetylation0.00007322Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008954 SSF48678 Protein matches
Abstract

ERM proteins, highly related members of the larger protein 4.1 superfamily, can exist in an active or inactive conformation. The sole Drosophila ERM protein, Moesin, functions to promote cortical actin assembly and apical-basal polarity. As a result, cells lacking Moesin lose epithelial characteristics and adopt invasive migratory behaviour. Moesin appears to facilitate epithelial morphology not by providing an essential structural function, but rather by antagonizing activity of the small GTPase Rho. Thus, Moesin functions in maintaining epithelial integrity by regulating cell-signalling events that affect actin organization and polarity [PubMed12511959].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Moesin tail domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Moesin tail domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]