SUPERFAMILY 1.75 HMM library and genome assignments server


Transducin (heterotrimeric G protein), gamma chain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Non-globular all-alpha subunits of globular proteins [ 48661] (14)
Superfamily:   Transducin (heterotrimeric G protein), gamma chain [ 48670]
Families:   Transducin (heterotrimeric G protein), gamma chain [ 48671]


Superfamily statistics
Genomes (282) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,572 0 8
Proteins 1,572 0 8


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process4.408e-120.0005231Least InformativeDirect
Biological Process (BP)single-organism cellular process1.324e-052.037e-07Least InformativeDirect
Biological Process (BP)regulation of cellular process3.019e-100Least InformativeDirect
Biological Process (BP)response to stimulus2.226e-103.722e-15Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.0084670.1137Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0034010.1791Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.035560.2246Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.066930.428Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.00032040.0149Least InformativeInherited
Biological Process (BP)signal transduction1.104e-052.097e-12Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.00039270.0005549Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.47461Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.0029240.03635Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0054390.01886Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.00012120.003039Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0011680.0006085Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process8.531e-050.002421Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.0025670.0754Moderately InformativeInherited
Biological Process (BP)response to organic substance0.088440.3201Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0072340.04529Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.031520.3422Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.0065952.812e-08Moderately InformativeInherited
Biological Process (BP)system process0.0048570.007911Moderately InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process5.165e-084.614e-06InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process1.153e-071.567e-05InformativeDirect
Biological Process (BP)energy derivation by oxidation of organic compounds1.102e-095.751e-08InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process1.085e-067.534e-05InformativeDirect
Biological Process (BP)single-organism behavior2.319e-061.009e-06InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process1.855e-079.731e-06InformativeDirect
Biological Process (BP)organophosphate catabolic process8.574e-087.127e-06InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process1.808e-071.446e-05InformativeDirect
Biological Process (BP)glycosyl compound catabolic process4.011e-083.762e-06InformativeDirect
Biological Process (BP)cellular response to nitrogen compound7.338e-073.366e-06InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.0049430.002948InformativeInherited
Biological Process (BP)response to hormone stimulus0.0039790.001029InformativeInherited
Biological Process (BP)response to organonitrogen compound0.0003220.001667InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus8.454e-080.03982InformativeInherited
Biological Process (BP)cell-cell signaling0.0031470.5902InformativeInherited
Biological Process (BP)transmission of nerve impulse0.00014670.1967InformativeInherited
Biological Process (BP)energy reserve metabolic process1.874e-145.311e-12Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway5.923e-050Highly InformativeDirect
Biological Process (BP)purine ribonucleotide catabolic process1.675e-082.889e-06Highly InformativeDirect
Biological Process (BP)purine ribonucleoside triphosphate catabolic process1.024e-081.871e-06Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus5.9e-110.0002314Highly InformativeDirect
Biological Process (BP)purine ribonucleoside catabolic process1.937e-082.601e-06Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process3.149e-091.096e-09Highly InformativeDirect
Biological Process (BP)cellular response to peptide1.86e-122.397e-09Highly InformativeDirect
Molecular Function (MF)binding0.18930.3769Least InformativeInherited
Molecular Function (MF)hydrolase activity0.017790.06146Least InformativeInherited
Molecular Function (MF)nucleoside-triphosphatase activity1.418e-061.84e-05InformativeDirect
Molecular Function (MF)molecular transducer activity7.009e-080.0005331InformativeDirect
Cellular Component (CC)membrane5.155e-126.054e-09Least InformativeDirect
Cellular Component (CC)protein complex2.874e-082.271e-05Least InformativeDirect
Cellular Component (CC)plasma membrane1.691e-131.748e-11Moderately InformativeDirect
Cellular Component (CC)internal side of plasma membrane7.654e-141.492e-14Highly InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane1.269e-121.492e-14Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0005231 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.037e-07 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 3.722e-15 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.1137 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1791 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.2246 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.428 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.0149 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.8994 Least Informative Inherited
Biological Process (BP) signal transduction 2.097e-12 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 2.812e-08 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 1.922e-15 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 1.506e-12 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0006085 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0005549 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.03635 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01886 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.003039 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.002421 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.0754 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.3201 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.02442 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.001968 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.04529 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.3422 Moderately Informative Inherited
Biological Process (BP) system process 0.007911 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 4.614e-06 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 1.567e-05 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 5.751e-08 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 1.761e-14 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 7.534e-05 Informative Direct
Biological Process (BP) single-organism behavior 1.009e-06 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 9.731e-06 Informative Direct
Biological Process (BP) organophosphate catabolic process 7.127e-06 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0001015 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 1.446e-05 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 3.762e-06 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 3.366e-06 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.002948 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.001029 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.001667 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.03982 Informative Inherited
Biological Process (BP) cell-cell signaling 0.5902 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.1967 Informative Inherited
Biological Process (BP) energy reserve metabolic process 5.311e-12 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 2.212e-12 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 2.889e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 1.871e-06 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.0002314 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 2.601e-06 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 1.096e-09 Highly Informative Direct
Biological Process (BP) cellular response to peptide 2.397e-09 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.004007 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.001044 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.002965 Highly Informative Inherited
Molecular Function (MF) binding 0.3769 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.06146 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 1.84e-05 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0005331 Informative Direct
Molecular Function (MF) GTPase activator activity 1.627e-11 Highly Informative Direct
Cellular Component (CC) membrane 6.054e-09 Least Informative Direct
Cellular Component (CC) protein complex 2.271e-05 Least Informative Direct
Cellular Component (CC) plasma membrane 1.748e-11 Moderately Informative Direct
Cellular Component (CC) cell projection 2.8e-07 Moderately Informative Direct
Cellular Component (CC) neuron projection 0.05136 Informative Inherited
Cellular Component (CC) internal side of plasma membrane 1.492e-14 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 1.492e-14 Highly Informative Direct
Cellular Component (CC) dendrite 0.3061 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal eye physiology0.003543InformativeInherited
Mammalian Phenotype (MP)abnormal eye electrophysiology0.0002909Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0009551Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processSensory transduction2.257e-12InformativeDirect
Biological processVision0.0001285Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane7.849e-05Moderately InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationPrenylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015898 SSF48670 Protein matches
Abstract

This entry represents the G protein gamma subunit and the GGL (G protein gamma-like) domain, which are related in sequence and are comprised of an extended alpha-helical polypeptide. The G protein gamma subunit forms a stable dimer with the beta subunit, but it does not make any contact with the alpha subunit, which contacts the opposite face of the beta subunit. The GGL domain is found in several RGS proteins. GGL domains can interact with beta subunits to form novel dimers that prevent gamma subunit binding, and may prevent heterotrimer formation by inhibiting alpha subunit binding. The interaction between G protein beta-5 neuro-specific isoforms and RGS GGL domains may represent a general mode of binding between beta-propeller proteins and their partners [PubMed11331068].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transducin (heterotrimeric G protein), gamma chain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Transducin (heterotrimeric G protein), gamma chain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]