SUPERFAMILY 1.75 HMM library and genome assignments server


Transducin (heterotrimeric G protein), gamma chain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Non-globular all-alpha subunits of globular proteins [ 48661] (14)
Superfamily:   Transducin (heterotrimeric G protein), gamma chain [ 48670]
Families:   Transducin (heterotrimeric G protein), gamma chain [ 48671]


Superfamily statistics
Genomes (263) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 1,532 1,328 8
Proteins 1,532 1,328 8


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process2.357e-120.0005093Least InformativeDirect
Biological Process (BP)single-organism cellular process1.178e-051.738e-07Least InformativeDirect
Biological Process (BP)regulation of cellular process2.236e-101.931e-15Least InformativeDirect
Biological Process (BP)response to stimulus1.216e-103.746e-15Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.0084480.1291Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0035760.2018Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.035770.2492Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.06750.4638Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.00034790.01842Least InformativeInherited
Biological Process (BP)signal transduction1.326e-053.562e-12Moderately InformativeDirect
Biological Process (BP)organic cyclic compound catabolic process0.00010640.0003499Moderately InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process3.726e-050.0002143Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.47151Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0055950.02191Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.0001220.003489Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0010820.0006485Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process8.696e-050.00278Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.0026870.08412Moderately InformativeInherited
Biological Process (BP)response to organic substance0.091810.3302Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0070730.04573Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.033530.3468Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.0062993.219e-08Moderately InformativeInherited
Biological Process (BP)system process0.0043670.007584Moderately InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process5.16e-085.043e-06InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process1.169e-071.691e-05InformativeDirect
Biological Process (BP)energy derivation by oxidation of organic compounds1.077e-096.842e-08InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process1.189e-069.018e-05InformativeDirect
Biological Process (BP)single-organism behavior2.108e-061.002e-06InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process1.829e-071.062e-05InformativeDirect
Biological Process (BP)organophosphate catabolic process9.32e-088.187e-06InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process1.98e-071.675e-05InformativeDirect
Biological Process (BP)glycosyl compound catabolic process4.397e-084.254e-06InformativeDirect
Biological Process (BP)cellular response to nitrogen compound7.369e-073.186e-06InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.0043650.002906InformativeInherited
Biological Process (BP)response to hormone stimulus0.004060.001085InformativeInherited
Biological Process (BP)response to organonitrogen compound0.00034150.001546InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus8.793e-080.03869InformativeInherited
Biological Process (BP)cell-cell signaling0.0033530.5581InformativeInherited
Biological Process (BP)transmission of nerve impulse0.0001570.1808InformativeInherited
Biological Process (BP)energy reserve metabolic process1.784e-145.419e-12Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway6.579e-050Highly InformativeDirect
Biological Process (BP)purine ribonucleotide catabolic process1.829e-083.243e-06Highly InformativeDirect
Biological Process (BP)purine ribonucleoside triphosphate catabolic process1.112e-082.08e-06Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus7.079e-110.0002172Highly InformativeDirect
Biological Process (BP)purine ribonucleoside catabolic process2.113e-082.911e-06Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process3.551e-091.483e-09Highly InformativeDirect
Biological Process (BP)cellular response to peptide2.284e-123.151e-09Highly InformativeDirect
Molecular Function (MF)binding0.25020.4397Least InformativeInherited
Molecular Function (MF)hydrolase activity0.018720.06848Least InformativeInherited
Molecular Function (MF)nucleoside-triphosphatase activity1.611e-062.137e-05InformativeDirect
Molecular Function (MF)molecular transducer activity3.939e-080.0004905InformativeDirect
Cellular Component (CC)membrane2.655e-123.339e-09Least InformativeDirect
Cellular Component (CC)protein complex2.545e-082.832e-05Least InformativeDirect
Cellular Component (CC)plasma membrane part3.478e-111.322e-06Moderately InformativeDirect
Cellular Component (CC)internal side of plasma membrane9.023e-141.558e-14Highly InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane1.487e-121.689e-14Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0005093 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.738e-07 Least Informative Direct
Biological Process (BP) regulation of cellular process 1.931e-15 Least Informative Direct
Biological Process (BP) response to stimulus 3.746e-15 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.1291 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2018 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.2492 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.4638 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.01842 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9074 Least Informative Inherited
Biological Process (BP) signal transduction 3.562e-12 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 3.219e-08 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 3.746e-15 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0003242 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 1.702e-12 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0006485 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 0.0003499 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0002143 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.02191 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.003489 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.00278 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.08412 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.3302 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.02506 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.04573 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.3468 Moderately Informative Inherited
Biological Process (BP) system process 0.007584 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 5.043e-06 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 1.691e-05 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 6.842e-08 Informative Direct
Biological Process (BP) regulation of nucleotide catabolic process 3.439e-05 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 9.018e-05 Informative Direct
Biological Process (BP) single-organism behavior 1.002e-06 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 1.062e-05 Informative Direct
Biological Process (BP) organophosphate catabolic process 8.187e-06 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 1.27e-06 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 1.675e-05 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 4.254e-06 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 3.186e-06 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.002906 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.001085 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.001546 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.03869 Informative Inherited
Biological Process (BP) cell-cell signaling 0.5581 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.1808 Informative Inherited
Biological Process (BP) energy reserve metabolic process 5.419e-12 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 2.024e-12 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 3.243e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 2.08e-06 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.0002172 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 2.664e-09 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 2.911e-06 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 1.483e-09 Highly Informative Direct
Biological Process (BP) cellular response to peptide 3.151e-09 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.004118 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.00109 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.003028 Highly Informative Inherited
Molecular Function (MF) binding 0.4397 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.06848 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 2.137e-05 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0004905 Informative Direct
Molecular Function (MF) GTPase activator activity 2.014e-11 Highly Informative Direct
Cellular Component (CC) membrane 3.339e-09 Least Informative Direct
Cellular Component (CC) protein complex 2.832e-05 Least Informative Direct
Cellular Component (CC) cell projection 3.502e-07 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 1.322e-06 Moderately Informative Direct
Cellular Component (CC) neuron projection 0.05371 Informative Inherited
Cellular Component (CC) internal side of plasma membrane 1.558e-14 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 1.689e-14 Highly Informative Direct
Cellular Component (CC) dendrite 0.2988 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.01064Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.0008988Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye physiology0.003321InformativeInherited
Mammalian Phenotype (MP)abnormal eye electrophysiology0.0002993Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0009551Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processSensory transduction2.127e-12InformativeDirect
Biological processVision0.0001264Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane7.474e-05Moderately InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationPrenylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015898 SSF48670 Protein matches
Abstract

This entry represents the G protein gamma subunit and the GGL (G protein gamma-like) domain, which are related in sequence and are comprised of an extended alpha-helical polypeptide. The G protein gamma subunit forms a stable dimer with the beta subunit, but it does not make any contact with the alpha subunit, which contacts the opposite face of the beta subunit. The GGL domain is found in several RGS proteins. GGL domains can interact with beta subunits to form novel dimers that prevent gamma subunit binding, and may prevent heterotrimer formation by inhibiting alpha subunit binding. The interaction between G protein beta-5 neuro-specific isoforms and RGS GGL domains may represent a general mode of binding between beta-propeller proteins and their partners [PubMed11331068].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transducin (heterotrimeric G protein), gamma chain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Transducin (heterotrimeric G protein), gamma chain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]