SUPERFAMILY 1.75 HMM library and genome assignments server

Transducin (heterotrimeric G protein), gamma chain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Non-globular all-alpha subunits of globular proteins [ 48661] (14)
Superfamily:   Transducin (heterotrimeric G protein), gamma chain [ 48670]
Families:   Transducin (heterotrimeric G protein), gamma chain [ 48671]


Superfamily statistics
Genomes (286) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,670 1,694 8
Proteins 1,670 1,694 8


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.0000000036520.00000000000005988Least InformativeDirect
Biological Process (BP)response to stimulus0.00000000054940.00000000000003576Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.11610.6325Least InformativeInherited
Biological Process (BP)single-organism cellular process0.004880.00004555Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.24650.9552Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.013170.3207Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.018690.2238Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.069170.3901Least InformativeInherited
Biological Process (BP)signal transduction0.0000023170.000000000001144Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.00040720.0003039Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.014350.08079Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.011970.09391Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.014150.07645Moderately InformativeInherited
Biological Process (BP)response to organic substance0.14240.4345Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.076870.4929Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.013680.05511Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.60091Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.0010860.01436Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.00080840.01162Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.013420.1951Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.023450.01638Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.035490.0000002426Moderately InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process0.0000023380.00007889InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process0.0000043060.0002028InformativeDirect
Biological Process (BP)energy derivation by oxidation of organic compounds0.0000041910.00007344InformativeDirect
Biological Process (BP)cellular response to hormone stimulus0.000000094410.0002097InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process0.000015060.0004873InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process0.0000064440.0001448InformativeDirect
Biological Process (BP)organophosphate catabolic process0.0000019940.00006768InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.0000035740.0001257InformativeDirect
Biological Process (BP)cellular response to nitrogen compound0.0000046290.00001731InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.012140.007838InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.00012040.001074InformativeInherited
Biological Process (BP)response to organonitrogen compound0.00085620.004236InformativeInherited
Biological Process (BP)energy reserve metabolic process0.0000000000022010.0000000003304Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.000002650Highly InformativeDirect
Biological Process (BP)purine nucleoside triphosphate catabolic process0.00000036490.00002192Highly InformativeDirect
Biological Process (BP)purine ribonucleotide catabolic process0.00000046440.00003006Highly InformativeDirect
Biological Process (BP)ribonucleoside triphosphate catabolic process0.00000030740.00002057Highly InformativeDirect
Biological Process (BP)response to peptide hormone0.0000000026460.0005782Highly InformativeDirect
Biological Process (BP)purine ribonucleoside catabolic process0.00000052180.00002737Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process0.0000001210.00000004601Highly InformativeDirect
Biological Process (BP)cellular response to peptide0.00000000012950.00000007065Highly InformativeDirect
Molecular Function (MF)binding0.16760.4597Least InformativeInherited
Molecular Function (MF)hydrolase activity0.051540.1335Least InformativeInherited
Molecular Function (MF)nucleoside-triphosphatase activity0.000015850.0001211InformativeDirect
Molecular Function (MF)molecular transducer activity0.000000045890.0003482InformativeDirect
Cellular Component (CC)membrane0.00000000010710.00000004585Least InformativeDirect
Cellular Component (CC)protein complex0.000000024280.00002033Least InformativeDirect
Cellular Component (CC)plasma membrane part0.000000000031870.000001843Moderately InformativeDirect
Cellular Component (CC)extrinsic component of cytoplasmic side of plasma membrane00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.00004555 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00000000000005988 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000000003576 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.6325 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9552 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.2995 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3207 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2238 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3901 Least Informative Inherited
Biological Process (BP) signal transduction 0.000000000001144 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00002712 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0000002426 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.00000000001116 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.000000000612 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0003039 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.08079 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.09391 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.07645 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4345 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.4929 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.002584 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.004534 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.05511 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6605 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.01436 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.01162 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.1951 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.01638 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.00007889 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.0002028 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.00000000003124 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.00007344 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.00000000000002753 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.0002097 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.0004873 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0001448 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00006768 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00003961 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0001257 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00001731 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.007838 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.001074 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.004236 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.02037 Informative Inherited
Biological Process (BP) energy reserve metabolic process 0.0000000003304 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.000000000006794 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.00002192 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.00003006 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.00002057 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0005782 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.00005595 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.00002737 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.00000004601 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.00000007065 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.008145 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.001242 Highly Informative Inherited
Molecular Function (MF) binding 0.4597 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.1335 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.0001211 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0003482 Informative Direct
Molecular Function (MF) GTPase activator activity 0.00000009326 Highly Informative Direct
Cellular Component (CC) membrane 0.00000004585 Least Informative Direct
Cellular Component (CC) protein complex 0.00002033 Least Informative Direct
Cellular Component (CC) cell projection 0.00000006463 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.000001843 Moderately Informative Direct
Cellular Component (CC) neuron projection 0.08455 Informative Inherited
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) dendrite 0.1918 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal eye physiology0.006304InformativeInherited
Mammalian Phenotype (MP)abnormal eye electrophysiology0.0005291Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0009551Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processSensory transduction0.000000000002323InformativeDirect
Biological processVision0.000123Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0.00008761Moderately InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationPrenylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015898 SSF48670 Protein matches
Abstract

This entry represents the G protein gamma subunit and the GGL (G protein gamma-like) domain, which are related in sequence and are comprised of an extended alpha-helical polypeptide. The G protein gamma subunit forms a stable dimer with the beta subunit, but it does not make any contact with the alpha subunit, which contacts the opposite face of the beta subunit. The GGL domain is found in several RGS proteins. GGL domains can interact with beta subunits to form novel dimers that prevent gamma subunit binding, and may prevent heterotrimer formation by inhibiting alpha subunit binding. The interaction between G protein beta-5 neuro-specific isoforms and RGS GGL domains may represent a general mode of binding between beta-propeller proteins and their partners [PubMed11331068].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transducin (heterotrimeric G protein), gamma chain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Transducin (heterotrimeric G protein), gamma chain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]