SUPERFAMILY 1.75 HMM library and genome assignments server


Transducin (heterotrimeric G protein), gamma chain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Non-globular all-alpha subunits of globular proteins [ 48661] (14)
Superfamily:   Transducin (heterotrimeric G protein), gamma chain [ 48670]
Families:   Transducin (heterotrimeric G protein), gamma chain [ 48671]


Superfamily statistics
Genomes (286) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,670 1,694 8
Proteins 1,670 1,694 8


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process2.51e-120.000541Least InformativeDirect
Biological Process (BP)single-organism cellular process1.367e-052.111e-07Least InformativeDirect
Biological Process (BP)regulation of cellular process2.122e-100Least InformativeDirect
Biological Process (BP)response to stimulus1.237e-101.944e-15Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.008640.1161Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0031130.183Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.035980.2289Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.06790.4353Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.00027290.01543Least InformativeInherited
Biological Process (BP)signal transduction1.104e-052.276e-12Moderately InformativeDirect
Biological Process (BP)organic cyclic compound catabolic process9.961e-050.0002895Moderately InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process3.441e-050.0001826Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.46571Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0054840.01945Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.0001090.00307Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0011850.000607Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process7.704e-050.002446Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.0023280.07652Moderately InformativeInherited
Biological Process (BP)response to organic substance0.092920.3356Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0071030.04433Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.034490.3678Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.0064443.397e-08Moderately InformativeInherited
Biological Process (BP)system process0.0048210.008034Moderately InformativeInherited
Biological Process (BP)synaptic transmission4.548e-127.577e-07InformativeDirect
Biological Process (BP)nucleoside triphosphate metabolic process4.611e-084.502e-06InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process1.014e-071.537e-05InformativeDirect
Biological Process (BP)energy derivation by oxidation of organic compounds9.352e-105.932e-08InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process9.257e-077.268e-05InformativeDirect
Biological Process (BP)single-organism behavior2.247e-061.149e-06InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process1.674e-079.725e-06InformativeDirect
Biological Process (BP)organophosphate catabolic process7.681e-086.969e-06InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process1.631e-071.427e-05InformativeDirect
Biological Process (BP)glycosyl compound catabolic process3.636e-083.665e-06InformativeDirect
Biological Process (BP)cellular response to nitrogen compound7.722e-073.368e-06InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.0050460.002934InformativeInherited
Biological Process (BP)response to hormone stimulus0.0045730.001167InformativeInherited
Biological Process (BP)response to organonitrogen compound0.00029120.001579InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus7.681e-080.03449InformativeInherited
Biological Process (BP)energy reserve metabolic process1.585e-145.579e-12Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway5.682e-050Highly InformativeDirect
Biological Process (BP)purine ribonucleotide catabolic process1.498e-082.798e-06Highly InformativeDirect
Biological Process (BP)purine ribonucleoside triphosphate catabolic process9.117e-091.806e-06Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus5.148e-110.0001816Highly InformativeDirect
Biological Process (BP)purine ribonucleoside catabolic process1.727e-082.517e-06Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process2.884e-091.293e-09Highly InformativeDirect
Biological Process (BP)cellular response to peptide1.628e-122.467e-09Highly InformativeDirect
Molecular Function (MF)binding0.17990.3886Least InformativeInherited
Molecular Function (MF)hydrolase activity0.016530.06328Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides4.022e-063.303e-05Moderately InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity1.25e-061.88e-05InformativeDirect
Molecular Function (MF)molecular transducer activity6.289e-080.0005356InformativeDirect
Cellular Component (CC)membrane8.217e-121.157e-08Least InformativeDirect
Cellular Component (CC)protein complex2.286e-082.452e-05Least InformativeDirect
Cellular Component (CC)plasma membrane6.213e-134.046e-11Moderately InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane1.244e-121.495e-14Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000541 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.111e-07 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1.944e-15 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.1161 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.183 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.2289 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.4353 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.01543 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.8913 Least Informative Inherited
Biological Process (BP) signal transduction 2.276e-12 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 3.397e-08 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 1.944e-15 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 1.348e-12 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.000607 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 0.0002895 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0001826 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01945 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.00307 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.002446 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.07652 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.3356 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.02451 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.002138 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.04433 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.3678 Moderately Informative Inherited
Biological Process (BP) system process 0.008034 Moderately Informative Inherited
Biological Process (BP) synaptic transmission 7.577e-07 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 4.502e-06 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 1.537e-05 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 5.932e-08 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 1.958e-14 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 7.268e-05 Informative Direct
Biological Process (BP) single-organism behavior 1.149e-06 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 9.725e-06 Informative Direct
Biological Process (BP) organophosphate catabolic process 6.969e-06 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0001098 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 1.427e-05 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 3.665e-06 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 3.368e-06 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.002934 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.001167 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.001579 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.03449 Informative Inherited
Biological Process (BP) energy reserve metabolic process 5.579e-12 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 2.021e-12 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 2.798e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 1.806e-06 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.0001816 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 2.517e-06 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.0009929 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 1.293e-09 Highly Informative Direct
Biological Process (BP) cellular response to peptide 2.467e-09 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.003953 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.002956 Highly Informative Inherited
Molecular Function (MF) binding 0.3886 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.06328 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 3.303e-05 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 1.88e-05 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0005356 Informative Direct
Molecular Function (MF) GTPase activator activity 1.636e-11 Highly Informative Direct
Cellular Component (CC) membrane 1.157e-08 Least Informative Direct
Cellular Component (CC) protein complex 2.452e-05 Least Informative Direct
Cellular Component (CC) plasma membrane 4.046e-11 Moderately Informative Direct
Cellular Component (CC) cell projection 2.61e-07 Moderately Informative Direct
Cellular Component (CC) neuron projection 0.05161 Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 1.495e-14 Highly Informative Direct
Cellular Component (CC) dendrite 0.3107 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal eye physiology0.003651InformativeInherited
Mammalian Phenotype (MP)abnormal eye electrophysiology0.0002989Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0009551Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processSensory transduction2.227e-12InformativeDirect
Biological processVision0.0001287Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane8.305e-05Moderately InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationPrenylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015898 SSF48670 Protein matches
Abstract

This entry represents the G protein gamma subunit and the GGL (G protein gamma-like) domain, which are related in sequence and are comprised of an extended alpha-helical polypeptide. The G protein gamma subunit forms a stable dimer with the beta subunit, but it does not make any contact with the alpha subunit, which contacts the opposite face of the beta subunit. The GGL domain is found in several RGS proteins. GGL domains can interact with beta subunits to form novel dimers that prevent gamma subunit binding, and may prevent heterotrimer formation by inhibiting alpha subunit binding. The interaction between G protein beta-5 neuro-specific isoforms and RGS GGL domains may represent a general mode of binding between beta-propeller proteins and their partners [PubMed11331068].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transducin (heterotrimeric G protein), gamma chain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Transducin (heterotrimeric G protein), gamma chain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]