SUPERFAMILY 1.75 HMM library and genome assignments server

Please note: Superfamily is currently under maintenance and some functionality may be limited. Please bear with us as we fix these problems.


Transducin (heterotrimeric G protein), gamma chain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Non-globular all-alpha subunits of globular proteins [ 48661] (14)
Superfamily:   Transducin (heterotrimeric G protein), gamma chain [ 48670]
Families:   Transducin (heterotrimeric G protein), gamma chain [ 48671]


Superfamily statistics
Genomes (286) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,670 1,694 8
Proteins 1,670 1,694 8


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0000000000027030.0006258Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00001260.0000002002Least InformativeDirect
Biological Process (BP)regulation of cellular process0.00000000030130.000000000000001938Least InformativeDirect
Biological Process (BP)response to stimulus0.00000000017170.000000000000003755Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.0088410.1258Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.003730.1971Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.03640.2436Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.069530.4595Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.00037090.01834Least InformativeInherited
Biological Process (BP)signal transduction0.0000097180.000000000001667Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.4651Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.0031320.04098Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0055010.02147Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.00014390.003546Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0013590.0006908Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.00010380.002802Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.0027990.08209Moderately InformativeInherited
Biological Process (BP)response to organic substance0.094720.3441Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0072850.04612Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.034460.375Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.0071260.00000004451Moderately InformativeInherited
Biological Process (BP)system process0.0050590.008266Moderately InformativeInherited
Biological Process (BP)synaptic transmission0.000000000005030.0000008529InformativeDirect
Biological Process (BP)nucleoside triphosphate metabolic process0.000000069160.000005303InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process0.0000001520.00001773InformativeDirect
Biological Process (BP)energy derivation by oxidation of organic compounds0.0000000010710.00000006617InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process0.0000012780.0000828InformativeDirect
Biological Process (BP)single-organism behavior0.0000026510.000001421InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process0.00000025330.00001153InformativeDirect
Biological Process (BP)organophosphate catabolic process0.00000012310.000008317InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.00000023290.00001663InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process0.000034640.0002065InformativeDirect
Biological Process (BP)cellular response to nitrogen compound0.00000079960.000003362InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.0052510.003011InformativeInherited
Biological Process (BP)response to hormone stimulus0.0043260.001125InformativeInherited
Biological Process (BP)response to organonitrogen compound0.00027810.001517InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.000000088480.0359InformativeInherited
Biological Process (BP)energy reserve metabolic process0.000000000000018560.00000000000637Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.000058180Highly InformativeDirect
Biological Process (BP)purine nucleoside triphosphate catabolic process0.000000017150.000002244Highly InformativeDirect
Biological Process (BP)purine ribonucleotide catabolic process0.000000022720.000003236Highly InformativeDirect
Biological Process (BP)ribonucleoside triphosphate catabolic process0.0000000140.000002085Highly InformativeDirect
Biological Process (BP)purine ribonucleoside triphosphate metabolic process0.000000022330.000003388Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus0.000000000059630.0001889Highly InformativeDirect
Biological Process (BP)purine ribonucleoside catabolic process0.000000026040.000002904Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process0.0000000047290.000000001814Highly InformativeDirect
Biological Process (BP)cellular response to peptide0.0000000000018910.00000000294Highly InformativeDirect
Molecular Function (MF)binding0.19810.4291Least InformativeInherited
Molecular Function (MF)hydrolase activity0.018080.06776Least InformativeInherited
Molecular Function (MF)nucleoside-triphosphatase activity0.0000013360.00001974InformativeDirect
Molecular Function (MF)molecular transducer activity0.000000066630.0005632InformativeDirect
Cellular Component (CC)membrane0.000000000010690.00000001504Least InformativeDirect
Cellular Component (CC)protein complex0.000000025490.00002779Least InformativeDirect
Cellular Component (CC)plasma membrane0.0000000000007710.00000000004662Moderately InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane0.0000000000011320.00000000000001474Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0006258 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000002002 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.000000000000001938 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000000000003755 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.1258 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1971 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.2436 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.4595 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.01834 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.8975 Least Informative Inherited
Biological Process (BP) signal transduction 0.000000000001667 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00000004451 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.000000000000003755 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000000000001278 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0006908 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.04098 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.02147 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.003546 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.002802 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.08209 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.3441 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.02324 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.001868 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.04612 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.375 Moderately Informative Inherited
Biological Process (BP) system process 0.008266 Moderately Informative Inherited
Biological Process (BP) synaptic transmission 0.0000008529 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.000005303 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.00001773 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.00000006617 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.00000000000002119 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.0000828 Informative Direct
Biological Process (BP) single-organism behavior 0.000001421 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.00001153 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.000008317 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00008389 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.00001663 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0002065 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.000003362 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.003011 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.001125 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.001517 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.0359 Informative Inherited
Biological Process (BP) energy reserve metabolic process 0.00000000000637 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.000000000002115 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.000002244 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.000003236 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.000002085 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.000003388 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.0001889 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.00004155 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.000002904 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.0009979 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.000000001814 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.00000000294 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.004086 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.00295 Highly Informative Inherited
Molecular Function (MF) binding 0.4291 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.06776 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.00001974 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0005632 Informative Direct
Molecular Function (MF) GTPase activator activity 0.0000000000183 Highly Informative Direct
Cellular Component (CC) membrane 0.00000001504 Least Informative Direct
Cellular Component (CC) protein complex 0.00002779 Least Informative Direct
Cellular Component (CC) plasma membrane 0.00000000004662 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000000348 Moderately Informative Direct
Cellular Component (CC) neuron projection 0.05422 Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 0.00000000000001474 Highly Informative Direct
Cellular Component (CC) dendrite 0.3001 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal eye physiology0.006304InformativeInherited
Mammalian Phenotype (MP)abnormal eye electrophysiology0.0005291Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0009551Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processSensory transduction0.000000000002323InformativeDirect
Biological processVision0.000123Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0.00008761Moderately InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationPrenylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015898 SSF48670 Protein matches
Abstract

This entry represents the G protein gamma subunit and the GGL (G protein gamma-like) domain, which are related in sequence and are comprised of an extended alpha-helical polypeptide. The G protein gamma subunit forms a stable dimer with the beta subunit, but it does not make any contact with the alpha subunit, which contacts the opposite face of the beta subunit. The GGL domain is found in several RGS proteins. GGL domains can interact with beta subunits to form novel dimers that prevent gamma subunit binding, and may prevent heterotrimer formation by inhibiting alpha subunit binding. The interaction between G protein beta-5 neuro-specific isoforms and RGS GGL domains may represent a general mode of binding between beta-propeller proteins and their partners [PubMed11331068].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transducin (heterotrimeric G protein), gamma chain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Transducin (heterotrimeric G protein), gamma chain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]