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Phospholipase A2, PLA2 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Phospholipase A2, PLA2 [ 48618]
Superfamily:   Phospholipase A2, PLA2 [ 48619] (3)
Families:   Vertebrate phospholipase A2 [ 48623] (2)
  Insect phospholipase A2 [ 48620]
  Prokaryotic phospholipase A2 [ 63630]

 Superfamily statistics
Genomes (318) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,063 2,965 86
Proteins 1,937 2,853 86

 Functional annotation
General category Processes_IC
Detailed category Phospholipid metabolism and transport

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process5.053e-096.875e-09Least InformativeDirect
Biological Process (BP)localization0.41451Least InformativeInherited
Biological Process (BP)biosynthetic process0.32930.2031Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.89120.9411Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process04.551e-12Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process00Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)multi-organism process1.664e-083.953e-06Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process8.85e-051.11e-06Moderately InformativeDirect
Biological Process (BP)lipid biosynthetic process0.0072980.0006674Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0018570.07153Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.0016939.448e-05Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.12570.2175Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.012780.1218Moderately InformativeInherited
Biological Process (BP)organic substance transport0.010040.04465Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.062680.0132Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.034860.001617Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process1.549e-073.414e-09InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process1.765e-061.457e-08InformativeDirect
Biological Process (BP)cellular biogenic amine metabolic process2.853e-082.639e-12InformativeDirect
Biological Process (BP)phospholipid metabolic process00InformativeDirect
Biological Process (BP)lipid transport1.735e-061.829e-06InformativeDirect
Biological Process (BP)lipid catabolic process3.615e-097.869e-11InformativeDirect
Biological Process (BP)regulation of system process2.265e-052.737e-05InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.10660.05195InformativeInherited
Biological Process (BP)organophosphate catabolic process0.018690.05334InformativeInherited
Biological Process (BP)regulation of muscle contraction3.896e-126.274e-09Highly InformativeDirect
Biological Process (BP)pathogenesis3.356e-066.984e-06Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism1.008e-052.464e-05Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process8.387e-140Highly InformativeDirect
Biological Process (BP)phosphatidic acid metabolic process1.091e-053.285e-09Highly InformativeDirect
Biological Process (BP)glycerophospholipid biosynthetic process5.353e-116.117e-14Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process0.027110.08968Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.21571Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)cation binding0.30380.09243Moderately InformativeInherited
Molecular Function (MF)protein binding0.7991Moderately InformativeInherited
Molecular Function (MF)receptor binding1.465e-070.0002147InformativeDirect
Molecular Function (MF)phospholipase activity00Highly InformativeDirect
Molecular Function (MF)calcium ion binding1.259e-066.781e-08Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect
Cellular Component (CC)extracellular region00Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 6.875e-09 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.2031 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.9411 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 4.551e-12 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0.0006674 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 3.953e-06 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 9.448e-05 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 1.11e-06 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.08492 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.07153 Moderately Informative Inherited
Biological Process (BP) ion transport 0.03056 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2175 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.04465 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1218 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.0132 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.001617 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 3.414e-09 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 1.457e-08 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 2.639e-12 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) anion transport 0.0008448 Informative Direct
Biological Process (BP) lipid transport 1.829e-06 Informative Direct
Biological Process (BP) lipid catabolic process 7.869e-11 Informative Direct
Biological Process (BP) regulation of system process 2.737e-05 Informative Direct
Biological Process (BP) positive regulation of transport 0.0007026 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.05195 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.05334 Informative Inherited
Biological Process (BP) regulation of muscle contraction 6.274e-09 Highly Informative Direct
Biological Process (BP) pathogenesis 6.984e-06 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 2.464e-05 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidic acid metabolic process 3.285e-09 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 6.117e-14 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.08968 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.09243 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0.0002147 Informative Direct
Molecular Function (MF) phospholipase activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 6.781e-08 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) extracellular region 0 Moderately Informative Direct
Cellular Component (CC) extracellular matrix 0.0002397 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)vascular disease0.004579Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.0001104InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processCytolysis4.589e-08InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DiseaseAllergen8.842e-05Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAntimicrobial6.586e-08InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationAntibiotic2.772e-11Highly InformativeDirect
Post-translational modificationNeurotoxin1Highly InformativeInherited
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phospholipase A2, PLA2 domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Phospholipase A2, PLA2 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.