SUPERFAMILY 1.75 HMM library and genome assignments server


Phospholipase A2, PLA2 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Phospholipase A2, PLA2 [ 48618]
Superfamily:   Phospholipase A2, PLA2 [ 48619] (3)
Families:   Vertebrate phospholipase A2 [ 48623] (2)
  Insect phospholipase A2 [ 48620]
  Prokaryotic phospholipase A2 [ 63630]


Superfamily statistics
Genomes (353) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,138 2,965 86
Proteins 2,005 2,853 86


Functional annotation
General category Processes_IC
Detailed category Phospholipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process1.884e-092.149e-11Least InformativeDirect
Biological Process (BP)localization0.34660.4263Least InformativeInherited
Biological Process (BP)biosynthetic process0.2890.3662Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.88780.5846Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process3.152e-152.447e-14Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process00Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)multi-organism process7.3e-092.554e-06Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.00011294.054e-09Moderately InformativeDirect
Biological Process (BP)lipid biosynthetic process0.0062650.001567Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0062030.1413Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.14430.4479Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0098630.09633Moderately InformativeInherited
Biological Process (BP)organic substance transport0.0074580.07801Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.072380.05572Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.030770.003187Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process1.469e-071.376e-11InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process1.248e-068.984e-09InformativeDirect
Biological Process (BP)cellular biogenic amine metabolic process1.411e-080InformativeDirect
Biological Process (BP)phospholipid metabolic process00InformativeDirect
Biological Process (BP)lipid localization2.541e-066.608e-06InformativeDirect
Biological Process (BP)lipid catabolic process3.502e-092.717e-10InformativeDirect
Biological Process (BP)regulation of system process0.00014580.0001997InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.08850.004504InformativeInherited
Biological Process (BP)organophosphate catabolic process0.022660.3167InformativeInherited
Biological Process (BP)regulation of muscle contraction1.707e-123.96e-09Highly InformativeDirect
Biological Process (BP)pathogenesis3.321e-054.962e-05Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process3.76e-140Highly InformativeDirect
Biological Process (BP)phosphatidic acid metabolic process8.617e-061.687e-07Highly InformativeDirect
Biological Process (BP)fatty acid derivative metabolic process0.00015561.557e-11Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process0.030210.6651Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process2.234e-110.01856Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.20561Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)cation binding0.3340.09621Moderately InformativeInherited
Molecular Function (MF)receptor binding7.009e-080.0001176InformativeDirect
Molecular Function (MF)phospholipase activity00Highly InformativeDirect
Molecular Function (MF)calcium ion binding6.762e-073.254e-08Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect
Cellular Component (CC)cell surface8.098e-070.0003092InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 2.149e-11 Least Informative Direct
Biological Process (BP) localization 0.4263 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.3662 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.5846 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2861 Least Informative Inherited
Biological Process (BP) developmental process 0.6574 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 2.447e-14 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 2.554e-06 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 4.054e-09 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0.001567 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1413 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.2855 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1186 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.4479 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.07801 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.09633 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.05572 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.003187 Moderately Informative Inherited
Biological Process (BP) immune system process 0.0623 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.05367 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.3379 Moderately Informative Inherited
Biological Process (BP) immune effector process 3.41e-05 Informative Direct
Biological Process (BP) alcohol metabolic process 1.376e-11 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 8.984e-09 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) anion transport 0.0007758 Informative Direct
Biological Process (BP) lipid localization 6.608e-06 Informative Direct
Biological Process (BP) lipid catabolic process 2.717e-10 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0001206 Informative Direct
Biological Process (BP) regulation of system process 0.0001997 Informative Direct
Biological Process (BP) cell projection organization 0.001973 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.004504 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.3167 Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1.026e-07 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 3.96e-09 Highly Informative Direct
Biological Process (BP) pathogenesis 4.962e-05 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidic acid metabolic process 1.687e-07 Highly Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 1.557e-11 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.2766 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 0.6651 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.01856 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0006532 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.09621 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0.0001176 Informative Direct
Molecular Function (MF) phospholipase activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 3.254e-08 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.1008 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.8325 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0001619 Moderately Informative Direct
Cellular Component (CC) extracellular region part 2.907e-05 Moderately Informative Direct
Cellular Component (CC) Golgi apparatus 0.0008013 Informative Direct
Cellular Component (CC) cell surface 0.0003092 Informative Direct
Cellular Component (CC) extracellular matrix 0.0002393 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0Moderately InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCytolysis3.107e-08InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DiseaseAllergen0.0002246Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAntimicrobial7.879e-08InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationAntibiotic3.546e-11Highly InformativeDirect
Post-translational modificationNeurotoxin1Highly InformativeInherited
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phospholipase A2, PLA2 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Phospholipase A2, PLA2 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]