SUPERFAMILY 1.75 HMM library and genome assignments server


Phospholipase A2, PLA2 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Phospholipase A2, PLA2 [ 48618]
Superfamily:   Phospholipase A2, PLA2 [ 48619] (3)
Families:   Vertebrate phospholipase A2 [ 48623] (2)
  Insect phospholipase A2 [ 48620]
  Prokaryotic phospholipase A2 [ 63630]


Superfamily statistics
Genomes (394) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,345 3,871 86
Proteins 2,202 3,731 86


Functional annotation
General category Processes_IC
Detailed category Phospholipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process9.301e-109.049e-12Least InformativeDirect
Biological Process (BP)localization0.39850.4621Least InformativeInherited
Biological Process (BP)biosynthetic process0.36820.431Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.9350.6497Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process05.576e-15Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process00Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)multi-organism process2.199e-084.608e-06Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.00017987.138e-09Moderately InformativeDirect
Biological Process (BP)lipid biosynthetic process0.0089990.002237Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.078650.3105Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.010970.1625Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.13910.04079Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.012180.1068Moderately InformativeInherited
Biological Process (BP)organic substance transport0.0088930.07702Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.093820.0668Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.039030.004151Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process1.637e-071.108e-11InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process1.838e-061.175e-08InformativeDirect
Biological Process (BP)cellular biogenic amine metabolic process1.872e-080InformativeDirect
Biological Process (BP)phospholipid metabolic process00InformativeDirect
Biological Process (BP)lipid localization3.144e-067.402e-06InformativeDirect
Biological Process (BP)lipid catabolic process4.494e-103.857e-11InformativeDirect
Biological Process (BP)regulation of system process0.00015640.0002501InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.10380.006006InformativeInherited
Biological Process (BP)organophosphate catabolic process0.0098810.2058InformativeInherited
Biological Process (BP)icosanoid metabolic process0.00089093.136e-08Highly InformativeDirect
Biological Process (BP)regulation of muscle contraction1.656e-124.082e-09Highly InformativeDirect
Biological Process (BP)pathogenesis3.51e-056.111e-05Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism2.025e-050.0001458Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process5.498e-140Highly InformativeDirect
Biological Process (BP)phosphatidic acid metabolic process7.713e-061.481e-07Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process0.028930.6708Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process2.648e-110.01678Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.16881Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)cation binding0.34210.1024Moderately InformativeInherited
Molecular Function (MF)receptor binding5.413e-092.044e-05InformativeDirect
Molecular Function (MF)calcium ion binding8.512e-074.271e-08Highly InformativeDirect
Molecular Function (MF)lipase activity00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect
Cellular Component (CC)cell surface1.217e-060.0004274InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 9.049e-12 Least Informative Direct
Biological Process (BP) localization 0.4621 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.431 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.6497 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.3338 Least Informative Inherited
Biological Process (BP) developmental process 0.5685 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 5.576e-15 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 4.608e-06 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 7.138e-09 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0.002237 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3105 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1625 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.04079 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1202 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.07702 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1068 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.0668 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.004151 Moderately Informative Inherited
Biological Process (BP) immune system process 0.07798 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.06455 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.2611 Moderately Informative Inherited
Biological Process (BP) immune effector process 3.634e-05 Informative Direct
Biological Process (BP) alcohol metabolic process 1.108e-11 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 1.175e-08 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) anion transport 0.0008499 Informative Direct
Biological Process (BP) lipid localization 7.402e-06 Informative Direct
Biological Process (BP) lipid catabolic process 3.857e-11 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0001593 Informative Direct
Biological Process (BP) regulation of system process 0.0002501 Informative Direct
Biological Process (BP) cell projection organization 0.002502 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.006006 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.2058 Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1.007e-07 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 3.136e-08 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 4.082e-09 Highly Informative Direct
Biological Process (BP) pathogenesis 6.111e-05 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.0001458 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidic acid metabolic process 1.481e-07 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.2889 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 0.6708 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.01678 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0008966 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.1024 Moderately Informative Inherited
Molecular Function (MF) receptor binding 2.044e-05 Informative Direct
Molecular Function (MF) calcium ion binding 4.271e-08 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.8546 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.08681 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0002158 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0001638 Moderately Informative Direct
Cellular Component (CC) cell surface 0.0004274 Informative Direct
Cellular Component (CC) extracellular matrix 0.0003026 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.008713Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.0003846InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCytolysis3.445e-09InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DiseaseAllergen0.0002598Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAntimicrobial1.296e-08InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationAntibiotic2.58e-12Highly InformativeDirect
Post-translational modificationNeurotoxin1Highly InformativeInherited
Post-translational modificationIon channel impairing toxin1Highly InformativeInherited
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phospholipase A2, PLA2 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Phospholipase A2, PLA2 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]