SUPERFAMILY 1.75 HMM library and genome assignments server

Phospholipase A2, PLA2 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Phospholipase A2, PLA2 [ 48618]
Superfamily:   Phospholipase A2, PLA2 [ 48619] (3)
Families:   Vertebrate phospholipase A2 [ 48623] (2)
  Insect phospholipase A2 [ 48620]
  Prokaryotic phospholipase A2 [ 63630]


Superfamily statistics
Genomes (395) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,346 3,871 86
Proteins 2,203 3,731 86


Functional annotation
General category Processes_IC
Detailed category Phospholipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.00000026580.00000003715Least InformativeDirect
Biological Process (BP)biosynthetic process0.34940.4089Least InformativeInherited
Biological Process (BP)localization0.43160.5058Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.94310.6504Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0000035080.00829Least InformativeInherited
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.0000000000000032510.00000000000002089Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process00Moderately InformativeDirect
Biological Process (BP)single-organism catabolic process0.0005810.0003985Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00000028170.000001543Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.00095780.0006125Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.00027410.0000000123Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.10860.07763Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.078830.3029Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.034090.003629Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.1340.03995Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.011990.1034Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.007620.1344Moderately InformativeInherited
Biological Process (BP)organic substance transport0.0090470.06637Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.00000018630.000000000009176InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process0.0000014970.000000009591InformativeDirect
Biological Process (BP)cellular biogenic amine metabolic process0.000000018490InformativeDirect
Biological Process (BP)phospholipid metabolic process00InformativeDirect
Biological Process (BP)lipid localization0.0000037070.000007868InformativeDirect
Biological Process (BP)lipid catabolic process0.00000000026340.00000000002092InformativeDirect
Biological Process (BP)regulation of system process0.000011670.00001595InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.10260.006142InformativeInherited
Biological Process (BP)organophosphate catabolic process0.010070.1891InformativeInherited
Biological Process (BP)icosanoid metabolic process0.00076840.00000002198Highly InformativeDirect
Biological Process (BP)pathogenesis0.0000083150.00005073Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism0.000010070.0002065Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process0.000000000016870Highly InformativeDirect
Biological Process (BP)phosphatidic acid metabolic process0.0000076970.0000001404Highly InformativeDirect
Biological Process (BP)regulation of muscle system process0.0000000000039630.00000002226Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process0.028880.6718Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.000000000026080.01682Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.17471Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)cation binding0.34250.1024Moderately InformativeInherited
Molecular Function (MF)receptor binding0.0000000057250.00002105InformativeDirect
Molecular Function (MF)calcium ion binding0.00000084480.00000004466Highly InformativeDirect
Molecular Function (MF)lipase activity00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect
Cellular Component (CC)cell surface0.0000024460.0006575InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000003715 Least Informative Direct
Biological Process (BP) biosynthetic process 0.4089 Least Informative Inherited
Biological Process (BP) localization 0.5058 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.6504 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.00829 Least Informative Inherited
Biological Process (BP) developmental process 0.5734 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.3782 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.00000000000002089 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0003985 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000001543 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0006125 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0000000123 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.07763 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3029 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.03995 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.003629 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.06637 Moderately Informative Inherited
Biological Process (BP) ion transport 0.2328 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1034 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1344 Moderately Informative Inherited
Biological Process (BP) immune system process 0.07849 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.06568 Moderately Informative Inherited
Biological Process (BP) immune effector process 0.00003723 Informative Direct
Biological Process (BP) alcohol metabolic process 0.000000000009176 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.000000009591 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) anion transport 0.0009606 Informative Direct
Biological Process (BP) lipid localization 0.000007868 Informative Direct
Biological Process (BP) lipid catabolic process 0.00000000002092 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0001699 Informative Direct
Biological Process (BP) regulation of system process 0.00001595 Informative Direct
Biological Process (BP) cell projection organization 0.01232 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.006142 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.1891 Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.0000001091 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.00000002198 Highly Informative Direct
Biological Process (BP) pathogenesis 0.00005073 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.0002065 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidic acid metabolic process 0.0000001404 Highly Informative Direct
Biological Process (BP) regulation of muscle system process 0.00000002226 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.183 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 0.6718 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.01682 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0008799 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.1024 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0.00002105 Informative Direct
Molecular Function (MF) calcium ion binding 0.00000004466 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.7934 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.08995 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00022 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0001681 Moderately Informative Direct
Cellular Component (CC) cell surface 0.0006575 Informative Direct
Cellular Component (CC) extracellular matrix 0.0002705 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.008733Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.0003827InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)musculo-skeletal system0Moderately InformativeDirect
Drugbank ATC_code (DB)antiinflammatory and antirheumatic products, non-steroids0InformativeDirect
Drugbank ATC_code (DB)topical products for joint and muscular pain1InformativeInherited

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCytolysis0.000000003434InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DiseaseAllergen0.0002554Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAntimicrobial0.0000000128InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationAntibiotic0.00000000000255Highly InformativeDirect
Post-translational modificationNeurotoxin1Highly InformativeInherited
Post-translational modificationIon channel impairing toxin1Highly InformativeInherited
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phospholipase A2, PLA2 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Phospholipase A2, PLA2 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]