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Phospholipase A2, PLA2 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Phospholipase A2, PLA2 [ 48618]
Superfamily:   Phospholipase A2, PLA2 [ 48619] (3)
Families:   Vertebrate phospholipase A2 [ 48623] (2)
  Insect phospholipase A2 [ 48620]
  Prokaryotic phospholipase A2 [ 63630]


Superfamily statistics
Genomes (394) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,345 3,871 86
Proteins 2,202 3,731 86


Functional annotation
General category Processes_IC
Detailed category Phospholipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.00000000095970.000000000008674Least InformativeDirect
Biological Process (BP)localization0.40110.4696Least InformativeInherited
Biological Process (BP)biosynthetic process0.36780.4321Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.93740.6507Least InformativeInherited
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process00.000000000000005594Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process00Moderately InformativeDirect
Biological Process (BP)multi-organism process0.000000024190.000005267Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.00017440.000000006218Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.0010610.0006465Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.081280.311Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.011770.1685Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.14120.04276Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.012060.1071Moderately InformativeInherited
Biological Process (BP)organic substance transport0.0088580.07466Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.097670.06757Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.037520.003956Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.00000017090.00000000001166InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process0.0000018280.00000001159InformativeDirect
Biological Process (BP)cellular biogenic amine metabolic process0.000000018650InformativeDirect
Biological Process (BP)phospholipid metabolic process00InformativeDirect
Biological Process (BP)lipid localization0.0000031380.000007343InformativeDirect
Biological Process (BP)lipid catabolic process0.00000000041870.00000000003916InformativeDirect
Biological Process (BP)regulation of system process0.0001630.000273InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.10350.006045InformativeInherited
Biological Process (BP)organophosphate catabolic process0.011430.2063InformativeInherited
Biological Process (BP)icosanoid metabolic process0.00090480.00000003287Highly InformativeDirect
Biological Process (BP)regulation of muscle contraction0.0000000000016510.000000004125Highly InformativeDirect
Biological Process (BP)pathogenesis0.000042410.00007853Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process0.000000000000053730Highly InformativeDirect
Biological Process (BP)phosphatidic acid metabolic process0.0000077350.000000145Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process0.0290.6702Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.000000000026330.01683Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.17061Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)cation binding0.3420.1015Moderately InformativeInherited
Molecular Function (MF)receptor binding0.0000000057320.00002082InformativeDirect
Molecular Function (MF)calcium ion binding0.00000084370.00000004407Highly InformativeDirect
Molecular Function (MF)lipase activity00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect
Cellular Component (CC)cell surface0.0000012370.0004338InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000000000008674 Least Informative Direct
Biological Process (BP) localization 0.4696 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4321 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.6507 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.3413 Least Informative Inherited
Biological Process (BP) developmental process 0.5692 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.000000000000005594 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000005267 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0006465 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.000000006218 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.311 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1685 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.04276 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1193 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.07466 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1071 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.06757 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.003956 Moderately Informative Inherited
Biological Process (BP) immune system process 0.07816 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.06506 Moderately Informative Inherited
Biological Process (BP) immune effector process 0.00003645 Informative Direct
Biological Process (BP) alcohol metabolic process 0.00000000001166 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.00000001159 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) anion transport 0.0008462 Informative Direct
Biological Process (BP) lipid localization 0.000007343 Informative Direct
Biological Process (BP) lipid catabolic process 0.00000000003916 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0001617 Informative Direct
Biological Process (BP) regulation of system process 0.000273 Informative Direct
Biological Process (BP) cell projection organization 0.002534 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.006045 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.2063 Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.0000001031 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.00000003287 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0.000000004125 Highly Informative Direct
Biological Process (BP) pathogenesis 0.00007853 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidic acid metabolic process 0.000000145 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.2884 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 0.6702 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.01683 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0008868 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.1015 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0.00002082 Informative Direct
Molecular Function (MF) calcium ion binding 0.00000004407 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.8586 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.08829 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0002193 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0001658 Moderately Informative Direct
Cellular Component (CC) cell surface 0.0004338 Informative Direct
Cellular Component (CC) extracellular matrix 0.000305 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.008733Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.0003827InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCytolysis0.000000003434InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DiseaseAllergen0.0002554Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAntimicrobial0.0000000128InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationAntibiotic0.00000000000255Highly InformativeDirect
Post-translational modificationNeurotoxin1Highly InformativeInherited
Post-translational modificationIon channel impairing toxin1Highly InformativeInherited
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phospholipase A2, PLA2 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Phospholipase A2, PLA2 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]