SUPERFAMILY 1.75 HMM library and genome assignments server

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Heme oxygenase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Heme oxygenase-like [ 48612]
Superfamily:   Heme oxygenase-like [ 48613] (4)
Families:   Eukaryotic type heme oxygenase [ 48614] (3)
  Heme oxygenase HemO (PigA) [ 63627]
  TENA/THI-4 [ 101458] (8)
  PqqC-like [ 101463] (2)

Superfamily statistics
Genomes (1,521) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 3,493 8,460 31
Proteins 3,487 8,450 31

 Functional annotation
General category Metabolism
Detailed category Redox

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.24859.38e-06Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.062862.192e-06Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.15052.81e-05Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.08916.312e-06Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.059711.491e-06Least InformativeInherited
Biological Process (BP)cofactor metabolic process0.0014862.081e-14Moderately InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process4.95e-060InformativeDirect
Biological Process (BP)pigment metabolic process1.634e-057.663e-14InformativeDirect
Biological Process (BP)heme metabolic process3.242e-071.277e-07Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 2.192e-06 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 2.81e-05 Least Informative Direct
Biological Process (BP) single-organism metabolic process 9.38e-06 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1.491e-06 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 6.312e-06 Least Informative Direct
Biological Process (BP) cofactor metabolic process 2.081e-14 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.01552 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.02832 Moderately Informative Inherited
Biological Process (BP) tetrapyrrole metabolic process 0 Informative Direct
Biological Process (BP) pigment metabolic process 7.663e-14 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.03531 Informative Inherited
Biological Process (BP) heme metabolic process 1.277e-07 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 2.633e-09 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 0.06617 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.06088 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0 Highly Informative Direct
Molecular Function (MF) heme binding 4.655e-12 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.9751 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.08845 Least Informative Inherited
Cellular Component (CC) plastid 0.0002834 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red3.708e-15Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.04236Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.001816InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)In other compounds4.713e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.003042Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.04038Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen1.023e-14InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.001653InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPhotosynthesis2.715e-10InformativeDirect
Biological processThiamine biosynthesis1.738e-06Highly InformativeDirect
Cellular componentEndoplasmic reticulum2.051e-12Moderately InformativeDirect
Cellular componentPlastid0.0001105Moderately InformativeDirect
Cellular componentMicrosome6.33e-11Highly InformativeDirect
Cellular componentChloroplast7.185e-05Highly InformativeDirect
Molecular functionMetal-binding0.004477Least InformativeInherited
Molecular functionIron6.909e-16Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)thiamine metabolism5.982e-05InformativeDirect
UniPathway (UP)pyrroloquinoline quinone biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heme oxygenase-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Heme oxygenase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.