SUPERFAMILY 1.75 HMM library and genome assignments server


Serum albumin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Serum albumin-like [ 48551]
Superfamily:   Serum albumin-like [ 48552]
Families:   Serum albumin-like [ 48553] (2)


Superfamily statistics
Genomes (64) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 829 1,162 31
Proteins 311 441 11


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 1.75e-09 Least Informative Direct
Biological Process (BP) regulation of cellular process 2.236e-08 Least Informative Direct
Biological Process (BP) localization 2.011e-07 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.1088 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.3921 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.06214 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.0479 Least Informative Inherited
Biological Process (BP) regulation of programmed cell death 2.073e-11 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.035e-09 Moderately Informative Direct
Biological Process (BP) cellular localization 9.427e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0002074 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.1795 Moderately Informative Inherited
Biological Process (BP) reproduction 0.02915 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.002908 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.07329 Moderately Informative Inherited
Biological Process (BP) organelle localization 0 Informative Direct
Biological Process (BP) response to nutrient levels 0 Informative Direct
Biological Process (BP) steroid metabolic process 1.766e-10 Informative Direct
Biological Process (BP) negative regulation of cell death 2.738e-07 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0003734 Informative Direct
Biological Process (BP) response to wounding 0.0329 Informative Inherited
Biological Process (BP) defense response 0.6274 Informative Inherited
Biological Process (BP) regulation of immune response 0.001617 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.002585 Informative Inherited
Biological Process (BP) regulation of locomotion 0.002694 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1762 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1006 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1148 Informative Inherited
Biological Process (BP) cellular response to starvation 0 Highly Informative Direct
Biological Process (BP) interaction with host 0 Highly Informative Direct
Biological Process (BP) maintenance of location 0 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte migration 4.957e-12 Highly Informative Direct
Biological Process (BP) inflammatory response 2.809e-05 Highly Informative Direct
Molecular Function (MF) binding 1.289e-08 Least Informative Direct
Molecular Function (MF) anion binding 6.997e-12 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.6931 Moderately Informative Inherited
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) cofactor binding 3.054e-15 Informative Direct
Molecular Function (MF) lipid binding 5.282e-15 Informative Direct
Molecular Function (MF) DNA binding 3.772e-10 Informative Direct
Molecular Function (MF) receptor binding 0.0004278 Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) pyridoxal phosphate binding 0 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 3.374e-10 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 4.695e-09 Highly Informative Direct
Cellular Component (CC) protein complex 1.863e-05 Least Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 1.514e-05 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)female reproductive system disease0.0003974InformativeDirect

Document: DO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentSecreted0Moderately InformativeDirect
DiseaseAllergen7.165e-05Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding2.134e-12Least InformativeDirect
Molecular functionZinc1.283e-06Least InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Molecular functionNickel5.474e-15InformativeDirect
Molecular functionActin-binding4.957e-07InformativeDirect
Post-translational modificationDisulfide bond9.085e-16Least InformativeDirect
Post-translational modificationGlycoprotein9.291e-05Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationSulfation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000264 SSF48552 Protein matches
Abstract A number of serum transport proteins are known to be evolutionarily related, including albumin, alpha-fetoprotein, vitamin D-binding protein and afamin [PubMed2481749, PubMed2423133, PubMed7517938]. Albumin is the main protein of plasma; it binds water, cations (such as Ca2+, Na+ and K+), fatty acids, hormones, bilirubin and drugs - its main function is to regulate the colloidal osmotic pressure of blood. Alphafeto- protein (alpha-fetoglobulin) is a foetal plasma protein that binds various cations, fatty acids and bilirubin. Vitamin D-binding protein binds to vitamin D and its metabolites, as well as to fatty acids. The biological role of afamin (alpha-albumin) has not yet been characterised. The 3D structure of human serum albumin has been determined by X-ray crystallography to a resolution of 2.8A [PubMed1630489]. It comprises three homologous domains that assemble to form a heart-shaped molecule [PubMed1630489]. Each domain is a product of two subdomains that possess common structural motifs [PubMed1630489]. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry. Structurally, the serum albumins are similar, each domain containing five or six internal disulphide bonds, as shown schematically below:
                    +---+          +----+                        +-----+
                    |   |          |    |                        |     |
 xxCxxxxxxxxxxxxxxxxCCxxCxxxxCxxxxxCCxxxCxxxxxxxxxCxxxxxxxxxxxxxxCCxxxxCxxxx
   |                 |       |     |              |               |
   +-----------------+       +-----+              +---------------+

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Serum albumin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Serum albumin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · UniProtKB KeyWords (KW) · Internal database links ]