SUPERFAMILY 1.75 HMM library and genome assignments server

Tetracyclin repressor-like, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Tetracyclin repressor-like, C-terminal domain [ 48497]
Superfamily:   Tetracyclin repressor-like, C-terminal domain [ 48498]
Families:   Tetracyclin repressor-like, C-terminal domain [ 48499] (34)

Superfamily statistics
Genomes (1,935) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,962 130,074 47
Proteins 25,935 129,989 47

Functional annotation
General category Information
Detailed category Transcription

Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.0000463 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.4637 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0.0000000004545 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0004064 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.01377 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.006091 Moderately Informative Inherited
Molecular Function (MF) binding 0.4508 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.0008262 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0.0000003729 Informative Direct
Molecular Function (MF) DNA binding 0.00002283 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCell cycle0Moderately InformativeDirect
Biological processAntibiotic resistance0.000001737InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011075 SSF48498 Protein matches

This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis [PubMed7707374]. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. Other members of the TetR family of transcriptional regulators carry this C-terminal domain. These include:

  • QacR from Staphylococcus aureus, a multidrug binding protein that represses transcription of the qacA multidrug transporter gene [PubMed11739955]
  • Ethr, a repressor from Mycobacterium tuberculosis implicated in ethionamide drug resistance [PubMed15236969]
  • CprB, a gamma-butyrolactone autoregulator/receptor from Streptomyces coelicolor that acts as a DNA-binding protein [PubMed14757054]
  • YcdC, a hypothetical transcriptional regulator from Escherichia coli
  • YsiA, YfiR, and YxaF, hypothetical transcriptional regulators from Bacillus subtilis
  • YbiH, a hypothetical transcriptional regulator from Salmonella typhimurium

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 34 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Tetracyclin repressor-like, C-terminal domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 34 hidden Markov models representing the Tetracyclin repressor-like, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]