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Tetracyclin repressor-like, C-terminal domain superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Information |
| Detailed category | Transcription |
Document: Function annotation of SCOP domain superfamilies
Gene Ontology (high-coverage) (show details)
Highlighted in gray are those with either FDR_singleton>0.001 or FDR_all>0.001
Document: GO annotation of SCOP domains
UniProtKB KeyWords (KW) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: KW annotation of SCOP domains
InterPro annotation
| Cross references | IPR011075 SSF48498 Protein matches |
| Abstract | This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis [ 7707374]. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. Other members of the TetR family of transcriptional regulators carry this C-terminal domain. These include:
- QacR from Staphylococcus aureus, a multidrug binding protein that represses transcription of the qacA multidrug transporter gene [11739955]
- Ethr, a repressor from Mycobacterium tuberculosis implicated in ethionamide drug resistance [15236969]
- CprB, a gamma-butyrolactone autoregulator/receptor from Streptomyces coelicolor that acts as a DNA-binding protein [14757054]
- YcdC, a hypothetical transcriptional regulator from Escherichia coli
- YsiA, YfiR, and YxaF, hypothetical transcriptional regulators from Bacillus subtilis
- YbiH, a hypothetical transcriptional regulator from Salmonella typhimurium
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InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 34 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Tetracyclin repressor-like, C-terminal domain domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 34 hidden Markov models representing the Tetracyclin repressor-like, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]
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