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Lipoxigenase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Lipoxigenase [ 48483]
Superfamily:   Lipoxigenase [ 48484] (2)
Families:   Plant lipoxigenases [ 48485]
  Animal lipoxigenases [ 48489]

 Superfamily statistics
Genomes (205) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 1,722 1,711 14
Proteins 1,620 1,666 14

 Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)oxidoreductase activity4.533e-050Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen3.766e-090Highly InformativeDirect
Molecular Function (MF)dioxygenase activity1.361e-080Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 7.392e-05 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1.019e-11 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.007043 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.03232 Least Informative Inherited
Biological Process (BP) lipid biosynthetic process 3.158e-05 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 4.185e-06 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0001131 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.002333 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.09809 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 1.578e-06 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) regulation of growth 8.384e-06 Informative Direct
Biological Process (BP) regulation of cell proliferation 1.438e-07 Informative Direct
Biological Process (BP) regulation of apoptotic process 5.622e-05 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0008934 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 1.39e-06 Informative Direct
Biological Process (BP) defense response 0.0141 Informative Inherited
Biological Process (BP) inflammatory response 0.0003878 Highly Informative Direct
Biological Process (BP) lipid modification 0.0009392 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 2.383e-08 Highly Informative Direct
Biological Process (BP) icosanoid biosynthetic process 4.5e-08 Highly Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 0 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.1849 Least Informative Inherited
Cellular Component (CC) cytosol 8.921e-05 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.07334Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.0003074Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.008478Moderately InformativeInherited
Disease Ontology (DO)cognitive disorder0.01144Moderately InformativeInherited
Disease Ontology (DO)carcinoma0InformativeDirect
Disease Ontology (DO)adenoma6.068e-06InformativeDirect
Disease Ontology (DO)Alzheimer's disease0.0006252Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)integument phenotype0.01332Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology9.417e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)liver and biliary system0InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)pedicel0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)stalk0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)phyllome apex0Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0Least InformativeDirect
Plant ANatomical entity (PAN)root0.6705Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.875Least InformativeInherited
Plant ANatomical entity (PAN)primordium1.84e-06InformativeDirect
Plant ANatomical entity (PAN)lateral root primordium2.559e-08Highly InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With incorporation of two atoms of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Cellular componentCytoplasm0.0002506Least InformativeDirect
Cellular componentPlastid2.066e-06Moderately InformativeDirect
Cellular componentChloroplast4.209e-08Highly InformativeDirect
DomainTransit peptide7.287e-09Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDioxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)oxylipin biosynthesis0Highly InformativeDirect
UniPathway (UP)leukotriene biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR013819 SSF48484 Protein matches
Abstract

This entry represents the C-terminal region of these proteins.


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lipoxigenase domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Lipoxigenase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.