SUPERFAMILY 1.75 HMM library and genome assignments server

Lipoxigenase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Lipoxigenase [ 48483]
Superfamily:   Lipoxigenase [ 48484] (2)
Families:   Plant lipoxigenases [ 48485]
  Animal lipoxigenases [ 48489]


Superfamily statistics
Genomes (260) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,330 2,416 14
Proteins 2,204 2,356 14


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)oxidoreductase activity0.00018230Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen0.0000000098310Highly InformativeDirect
Molecular Function (MF)dioxygenase activity0.000000048170Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000000000001244 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000002685 Least Informative Direct
Biological Process (BP) response to stimulus 0.000003695 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000004852 Least Informative Direct
Biological Process (BP) developmental process 0.0001876 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.01125 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.8172 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.3161 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.05662 Least Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organ development 0.000000004612 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000007007 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000225 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.00005504 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.00006984 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.00009446 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.02605 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.7923 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.1184 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2864 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.6624 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.003768 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.5452 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2641 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.003713 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.004774 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01581 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.08811 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.002714 Moderately Informative Inherited
Biological Process (BP) defense response 0.1634 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.0000000000000406 Informative Direct
Biological Process (BP) regulation of MAPK cascade 0.000000006006 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0000003996 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.000001294 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.000002283 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.000006803 Informative Direct
Biological Process (BP) response to inorganic substance 0.00001732 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00004885 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00005635 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00009265 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0001244 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0001341 Informative Direct
Biological Process (BP) response to cytokine 0.0004267 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0004872 Informative Direct
Biological Process (BP) positive regulation of intracellular signal transduction 0.0005368 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0007636 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0007815 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.001322 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.01291 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.9055 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.7009 Informative Inherited
Biological Process (BP) regulation of immune response 0.00793 Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0 Highly Informative Direct
Biological Process (BP) response to calcium ion 0.0000000000004287 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response 0.00000000001328 Highly Informative Direct
Biological Process (BP) cellular response to metal ion 0.00000000002909 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0.00000000006532 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.00000000009987 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.0000000002653 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0000000008733 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.000000002393 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0.000000021 Highly Informative Direct
Biological Process (BP) phagocytosis 0.0000001893 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 0.00000057 Highly Informative Direct
Biological Process (BP) ossification 0.0000007586 Highly Informative Direct
Biological Process (BP) negative regulation of immune response 0.000001029 Highly Informative Direct
Biological Process (BP) inflammatory response 0.000001394 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000003244 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.000007269 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.00001361 Highly Informative Direct
Biological Process (BP) lipid modification 0.06837 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.003114 Highly Informative Inherited
Molecular Function (MF) binding 0.06564 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.00000000003745 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.0002978 Moderately Informative Direct
Molecular Function (MF) anion binding 0.6958 Moderately Informative Inherited
Molecular Function (MF) lipid binding 0.000001314 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 0 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.00000000006475 Highly Informative Direct
Cellular Component (CC) membrane 0.0003007 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.07638 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.3449 Least Informative Inherited
Cellular Component (CC) cytosol 0.000002665 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.02523 Moderately Informative Inherited
Cellular Component (CC) lipid particle 0.00000000003632 Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.00000000000207 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.000002004 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.05199Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.0002939Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.008521Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.03053Moderately InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.00003291InformativeDirect
Disease Ontology (DO)dementia0.0009691InformativeDirect
Disease Ontology (DO)adenoma0.000005815Highly InformativeDirect
Disease Ontology (DO)Alzheimer's disease0.0005972Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.05431Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.004419Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.02366InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.000006147Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)liver and biliary system0InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0.2673Least InformativeInherited
Plant ANatomical entity (PAN)root system0.3029Least InformativeInherited
Plant ANatomical entity (PAN)primordium0.000001939InformativeDirect
Plant ANatomical entity (PAN)lateral root primordium0.00000002382Highly InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.9462Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.313Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.7568Moderately InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases (mutases)0.06216InformativeInherited
Enzyme Commission (EC)With incorporation of two atoms of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Transferring hydroxy groups0.0000000004266Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid biosynthesis0.9293InformativeInherited
Cellular componentCytoplasm0.00002587Least InformativeDirect
Cellular componentPlastid0.000008883Moderately InformativeDirect
Cellular componentChloroplast0.00000007861InformativeDirect
Cellular componentLipid droplet0Highly InformativeDirect
DomainTransit peptide0.00000001688Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionCalcium0.00000000007529Moderately InformativeDirect
Molecular functionLipid-binding0.000000000004539InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDioxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)oxylipin biosynthesis0Highly InformativeDirect
UniPathway (UP)leukotriene biosynthesis0.0000000004755Highly InformativeDirect
UniPathway (UP)sphingolipid metabolism0.000007993Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR013819 SSF48484 Protein matches
Abstract

This entry represents the C-terminal region of these proteins.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lipoxigenase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Lipoxigenase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]