SUPERFAMILY 1.75 HMM library and genome assignments server

Please note: Superfamily is currently under maintenance and some functionality may be limited. Please bear with us as we fix these problems.


Lipoxigenase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Lipoxigenase [ 48483]
Superfamily:   Lipoxigenase [ 48484] (2)
Families:   Plant lipoxigenases [ 48485]
  Animal lipoxigenases [ 48489]


Superfamily statistics
Genomes (259) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,325 2,416 14
Proteins 2,199 2,356 14


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)oxidoreductase activity0.00018060Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen0.0000000098020Highly InformativeDirect
Molecular Function (MF)dioxygenase activity0.000000048040Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000000000001884 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000000669 Least Informative Direct
Biological Process (BP) response to stimulus 0.000003706 Least Informative Direct
Biological Process (BP) developmental process 0.0001888 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2898 Least Informative Inherited
Biological Process (BP) localization 0.04953 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.7719 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organ development 0.000000005384 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000005829 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00002656 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.00005974 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.001931 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02604 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.001759 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01167 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.08032 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.6234 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.003601 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.5343 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2635 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.8063 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2709 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.003498 Moderately Informative Inherited
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.000000000000001938 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.000000000000281 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.0000001 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0000003426 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0000009131 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.000001143 Informative Direct
Biological Process (BP) response to inorganic substance 0.00001696 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00004581 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00005625 Informative Direct
Biological Process (BP) negative regulation of cell death 0.00006631 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0001163 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0001661 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0003157 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.0004267 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0007242 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0.7024 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.001275 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.903 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.01611 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.00509 Informative Inherited
Biological Process (BP) regulation of immune response 0.008024 Informative Inherited
Biological Process (BP) defense response 0.196 Informative Inherited
Biological Process (BP) icosanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0 Highly Informative Direct
Biological Process (BP) response to calcium ion 0.0000000000004395 Highly Informative Direct
Biological Process (BP) cellular response to metal ion 0.00000000002876 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0.00000000006652 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0000000000991 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.0000000001234 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0000000008542 Highly Informative Direct
Biological Process (BP) negative regulation of immune response 0.000000002432 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.000000002435 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0.00000002136 Highly Informative Direct
Biological Process (BP) phagocytosis 0.0000002225 Highly Informative Direct
Biological Process (BP) ossification 0.0000005677 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 0.0000007498 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.000008825 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.000008965 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.00001547 Highly Informative Direct
Biological Process (BP) lipid modification 0.06901 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.003111 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.003765 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.06195 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.00000000003654 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.000301 Moderately Informative Direct
Molecular Function (MF) anion binding 0.6965 Moderately Informative Inherited
Molecular Function (MF) lipid binding 0.000001315 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 0 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.00000000006418 Highly Informative Direct
Cellular Component (CC) membrane 0.0002996 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.06945 Least Informative Inherited
Cellular Component (CC) cytosol 0.000002592 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.005795 Moderately Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 0.000000002462 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.000002277 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.05199Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.0002939Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.008521Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.03053Moderately InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.00003291InformativeDirect
Disease Ontology (DO)dementia0.0009691InformativeDirect
Disease Ontology (DO)adenoma0.000005815Highly InformativeDirect
Disease Ontology (DO)Alzheimer's disease0.0005972Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.05431Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.004419Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.02366InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.000006147Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)liver and biliary system0InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0.2673Least InformativeInherited
Plant ANatomical entity (PAN)root system0.3029Least InformativeInherited
Plant ANatomical entity (PAN)primordium0.000001939InformativeDirect
Plant ANatomical entity (PAN)lateral root primordium0.00000002382Highly InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.9462Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.313Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.7568Moderately InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases (mutases)0.06216InformativeInherited
Enzyme Commission (EC)With incorporation of two atoms of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Transferring hydroxy groups0.0000000004266Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid biosynthesis0.9293InformativeInherited
Cellular componentCytoplasm0.00002587Least InformativeDirect
Cellular componentPlastid0.000008883Moderately InformativeDirect
Cellular componentChloroplast0.00000007861InformativeDirect
Cellular componentLipid droplet0Highly InformativeDirect
DomainTransit peptide0.00000001688Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionCalcium0.00000000007529Moderately InformativeDirect
Molecular functionLipid-binding0.000000000004539InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDioxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)oxylipin biosynthesis0Highly InformativeDirect
UniPathway (UP)leukotriene biosynthesis0.0000000004755Highly InformativeDirect
UniPathway (UP)sphingolipid metabolism0.000007993Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR013819 SSF48484 Protein matches
Abstract

This entry represents the C-terminal region of these proteins.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lipoxigenase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Lipoxigenase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]