SUPERFAMILY 1.75 HMM library and genome assignments server

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TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,124) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 167,437 406,918 50
Proteins 123,666 317,615 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)localization0.3590.5242Least InformativeInherited
Biological Process (BP)single-organism cellular process0.95911Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0019010.0000000005464Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)protein metabolic process10.00000001469Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process10.000000000002123Least InformativeInherited
Biological Process (BP)cellular localization0.00033620.0000000004887Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.1171Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)nervous system development0.40451Moderately InformativeInherited
Biological Process (BP)cell differentiation0.8571Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process11Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0026270.000001847Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0054940.2869Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.96551Moderately InformativeInherited
Biological Process (BP)organelle organization0.003550.000000000000003755Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of developmental process0.0076031InformativeInherited
Biological Process (BP)regulation of organelle organization0.0029670.00002491InformativeInherited
Biological Process (BP)negative regulation of developmental process0.35861InformativeInherited
Biological Process (BP)regulation of cell development0.42691InformativeInherited
Biological Process (BP)generation of neurons0.14071InformativeInherited
Biological Process (BP)regulation of nervous system development0.28841InformativeInherited
Biological Process (BP)cell projection organization0.0044370.0001244InformativeInherited
Biological Process (BP)cellular component movement0.1170.0000827InformativeInherited
Biological Process (BP)microtubule-based process0.040330InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.00029851InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.13620.05596InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.00058160.06799InformativeInherited
Biological Process (BP)vesicle-mediated transport0.058311InformativeInherited
Biological Process (BP)protein folding0.0000062950Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization0.0000044770.0000002343Highly InformativeDirect
Biological Process (BP)cytoskeleton-dependent intracellular transport0.00027590Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization0.000000038470.0912Highly InformativeInherited
Biological Process (BP)negative regulation of cell differentiation0.22421Highly InformativeInherited
Biological Process (BP)microtubule-based movement0.0055430Highly InformativeInherited
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.035610.7633Highly InformativeInherited
Biological Process (BP)Golgi vesicle transport0.0044820.1479Highly InformativeInherited
Biological Process (BP)protein glycosylation0.044770.0628Highly InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity11Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring glycosyl groups0.79680.4249InformativeInherited
Molecular Function (MF)UDP-glycosyltransferase activity0.26270.003922Highly InformativeInherited
Cellular Component (CC)protein complex0.0000008510.000006572Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.00000016280.00004919Least InformativeDirect
Cellular Component (CC)membrane0.44381Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.092980.00001018Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.32660.9427Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.052160.001177Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.016760.3019Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.00022330.7173Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.00016580.7305Moderately InformativeInherited
Cellular Component (CC)intrinsic to membrane0.13291Moderately InformativeInherited
Cellular Component (CC)vesicle0.10181Moderately InformativeInherited
Cellular Component (CC)cell projection0.57560.00000004433Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.71820.6098Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.28860.9638Moderately InformativeInherited
Cellular Component (CC)mitochondrial part0.5331Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.000064140.07183InformativeInherited
Cellular Component (CC)mitochondrial membrane part0.03240.2048InformativeInherited
Cellular Component (CC)integral to membrane0.37721InformativeInherited
Cellular Component (CC)Golgi apparatus0.037821InformativeInherited
Cellular Component (CC)coated vesicle0.011470.4938InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.0015830.0008621InformativeInherited
Cellular Component (CC)Golgi-associated vesicle0.0000003210.000004732Highly InformativeDirect
Cellular Component (CC)intraflagellar transport particle0.00043740Highly InformativeDirect
Cellular Component (CC)intrinsic to organelle membrane0.000000000012640.00005013Highly InformativeDirect
Cellular Component (CC)organelle outer membrane0.000000091260.00000004447Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.00000001469 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000000000002123 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000000005464 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.5242 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0.000000000000003755 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000001847 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000000004887 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.0147 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3555 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2696 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2869 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.987 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.6599 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0.0000827 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) protein transport 0.0001821 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0001116 Informative Direct
Biological Process (BP) cell projection organization 0.0001244 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00002491 Informative Direct
Biological Process (BP) protein localization to organelle 0.0000001814 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.0000006378 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000003984 Informative Direct
Biological Process (BP) organelle assembly 0.000007081 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.8759 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) muscle system process 0.6544 Informative Inherited
Biological Process (BP) tube development 0.2355 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.006749 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.006557 Informative Inherited
Biological Process (BP) actin filament-based process 0.4103 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.4391 Informative Inherited
Biological Process (BP) blood circulation 0.6156 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.01011 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.11 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.1275 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.06799 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.299 Informative Inherited
Biological Process (BP) muscle structure development 0.4453 Informative Inherited
Biological Process (BP) muscle tissue development 0.2058 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.4577 Informative Inherited
Biological Process (BP) mitochondrion organization 0.05756 Informative Inherited
Biological Process (BP) chromosome organization 0.3318 Informative Inherited
Biological Process (BP) cell cycle process 0.001146 Informative Inherited
Biological Process (BP) RNA processing 0.06086 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.5043 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.3862 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.05596 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9371 Informative Inherited
Biological Process (BP) sexual reproduction 0.5866 Informative Inherited
Biological Process (BP) single organism reproductive process 0.553 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.822 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1729 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1611 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.05539 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.3339 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) protein methylation 0.0005682 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.0000003692 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.00000006793 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.00002119 Highly Informative Direct
Biological Process (BP) mitosis 0.00003008 Highly Informative Direct
Biological Process (BP) regulation of mitosis 0.0000005849 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0000002343 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0 Highly Informative Direct
Biological Process (BP) gene silencing 0.00005438 Highly Informative Direct
Biological Process (BP) protein import 0.0006988 Highly Informative Direct
Biological Process (BP) peptidyl-proline modification 0 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.0000000007842 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0.000005749 Highly Informative Direct
Biological Process (BP) cytoskeleton-dependent intracellular transport 0 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.00000007882 Highly Informative Direct
Biological Process (BP) cilium organization 0 Highly Informative Direct
Biological Process (BP) maintenance of location 0.000119 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0.0000167 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.0006536 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 0.00000009001 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.07203 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.04369 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.6285 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.7834 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.0912 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.009919 Highly Informative Inherited
Biological Process (BP) heart contraction 0.005021 Highly Informative Inherited
Biological Process (BP) renal system development 0.07712 Highly Informative Inherited
Biological Process (BP) response to ionizing radiation 0.9286 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.01358 Highly Informative Inherited
Biological Process (BP) spindle checkpoint 0.001684 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 1 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.05418 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 0.1203 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.01777 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.001722 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.003482 Highly Informative Inherited
Biological Process (BP) histone modification 0.1821 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.8564 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.03934 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.3961 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.002037 Highly Informative Inherited
Biological Process (BP) DNA replication 0.01218 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.07734 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.006296 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.7633 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1358 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.02063 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.02673 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.1479 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.0628 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.00239 Highly Informative Inherited
Biological Process (BP) mRNA catabolic process 0.02293 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.0003312 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.956 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.4249 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.00151 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.6786 Informative Inherited
Molecular Function (MF) enzyme binding 0.244 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) ligase activity 0.4188 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.06313 Informative Inherited
Molecular Function (MF) amide binding 0.003037 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.00000001692 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 0.000000000000001562 Highly Informative Direct
Molecular Function (MF) adenylyltransferase activity 0.00000000001182 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 0.003922 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.00372 Highly Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0.03514 Highly Informative Inherited
Molecular Function (MF) methyltransferase activity 0.9929 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.35 Highly Informative Inherited
Molecular Function (MF) protein transporter activity 0.008823 Highly Informative Inherited
Molecular Function (MF) drug binding 0.003702 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.3247 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.5253 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.001512 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.00001018 Least Informative Direct
Cellular Component (CC) protein complex 0.000006572 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00004919 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.001177 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9427 Least Informative Inherited
Cellular Component (CC) cell projection 0.00000004433 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.00000001989 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.7173 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.6098 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.7305 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.3019 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.9638 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.7334 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.00000000000114 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0008621 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.07183 Informative Inherited
Cellular Component (CC) microbody 0.03187 Informative Inherited
Cellular Component (CC) mitochondrial membrane part 0.2048 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) coated vesicle 0.4938 Informative Inherited
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 0.7472 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) chromosome 0.07491 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) Golgi-associated vesicle 0.000004732 Highly Informative Direct
Cellular Component (CC) intraflagellar transport particle 0 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 0.00005013 Highly Informative Direct
Cellular Component (CC) organelle outer membrane 0.00000004447 Highly Informative Direct
Cellular Component (CC) cilium part 0.0000000000006831 Highly Informative Direct
Cellular Component (CC) chromatin 0.009731 Highly Informative Inherited
Cellular Component (CC) microtubule associated complex 0.7323 Highly Informative Inherited
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0.0203 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited
Cellular Component (CC) centrosome 0.1505 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000004361InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.000000007897InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7939Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.3702InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0002925Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.008701Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3001Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.0001946Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of digit0.09247Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.2717Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.422Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.0003368InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the fundus0.006142InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral ventricles0.05458InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.1016InformativeInherited
Phenotypic Abnormality (PA)Postaxial polydactyly0.0002015Highly InformativeDirect
Phenotypic Abnormality (PA)Cataract0.0002736Highly InformativeDirect
Phenotypic Abnormality (PA)Ventriculomegaly0.0007048Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.3854Least InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.1516Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.00312InformativeInherited
Mammalian Phenotype (MP)abnormal primary cilium morphology0.08497Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.002705Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.007132Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.05727Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0001758Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0005997Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.02152Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.02421Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.109Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.0000001182InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.00002538InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0001813InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.003694InformativeInherited
Worm Phenotype (WP)male morphology variant0.007713InformativeInherited
Worm Phenotype (WP)copulation variant0.02665InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)mitotic spindle defective early emb0.000009735Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0003135Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0003952Highly InformativeDirect
Worm Phenotype (WP)nuclear number variant0.0007523Highly InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant0.0008091Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.001248Highly InformativeInherited
Worm Phenotype (WP)cell cycle variant0.00489Highly InformativeInherited
Worm Phenotype (WP)touch resistant0.1792Highly InformativeInherited

Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed0.00000001344Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.04157Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1729Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0.00004524Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.0006577Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.1096Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0009247Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.002565Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.004582Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3618Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5475Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000002228InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000002576InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.004819InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.000000004274Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.0000007042Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processDifferentiation0.00000000001349Moderately InformativeDirect
Biological processCell cycle0.00001139Moderately InformativeDirect
Biological processApoptosis0.00004352Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processNeurogenesis0.000000145InformativeDirect
Biological processInnate immunity0.000001227InformativeDirect
Biological processMeiosis0.00002837InformativeDirect
Biological processmRNA splicing0.00007795InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Biological processRNA-mediated gene silencing0.000000000004865Highly InformativeDirect
Biological processMyogenesis0.000000002118Highly InformativeDirect
Biological processChromosome partition0.00000000747Highly InformativeDirect
Biological processNonsense-mediated mRNA decay0.0000001023Highly InformativeDirect
Biological processAntiviral defense0.0000007968Highly InformativeDirect
Biological processUnfolded protein response0.000003421Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentMitochondrion0.000000000000006951Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000005554Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00002914Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSpliceosome0InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeroxisome0.000000000001892InformativeDirect
Cellular componentCell outer membrane0.000004035InformativeDirect
Cellular componentCilium0Highly InformativeDirect
Cellular componentProteasome0.00003786Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0006727Least InformativeDirect
DiseaseCiliopathy0.000000007593InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTPR repeat0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationActivator0.00000009092Moderately InformativeDirect
Post-translational modificationIsomerase0.798Moderately InformativeInherited
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationChaperone0.0000001692InformativeDirect
Post-translational modificationProtein phosphatase0.0000004131InformativeDirect
Post-translational modificationChromatin regulator0.000004658InformativeDirect
Post-translational modificationInitiation factor0.000007224InformativeDirect
Post-translational modificationRotamase0Highly InformativeDirect
Post-translational modificationDioxygenase0.00000000000003311Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00003849Moderately InformativeDirect
Post-translational modificationPalmitate0.0004483Moderately InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)glycan metabolism0.00000008814Moderately InformativeDirect
UniPathway (UP)cellulose metabolism0.000000000003507InformativeDirect
UniPathway (UP)bacterial cellulose biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]