SUPERFAMILY 1.75 HMM library and genome assignments server


TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,124) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 167,366 406,918 50
Proteins 123,623 317,615 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)localization0.36980.6548Least InformativeInherited
Biological Process (BP)single-organism cellular process0.94110.9913Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0018561.933e-09Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)protein metabolic process11.667e-08Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process16.927e-12Least InformativeInherited
Biological Process (BP)cellular localization0.00029648.429e-10Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.10421Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)nervous system development0.39561Moderately InformativeInherited
Biological Process (BP)cell differentiation0.85761Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process11Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.00251.623e-06Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0048070.2804Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.93841Moderately InformativeInherited
Biological Process (BP)organelle organization0.0033253.77e-15Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of developmental process0.0069061InformativeInherited
Biological Process (BP)regulation of organelle organization0.003081.312e-05InformativeInherited
Biological Process (BP)negative regulation of developmental process0.32931InformativeInherited
Biological Process (BP)regulation of cell development0.39041InformativeInherited
Biological Process (BP)generation of neurons0.14171InformativeInherited
Biological Process (BP)regulation of nervous system development0.27671InformativeInherited
Biological Process (BP)cell projection organization0.0040177.658e-05InformativeInherited
Biological Process (BP)cellular component movement0.11880.0001968InformativeInherited
Biological Process (BP)microtubule-based process0.040930InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.00024691InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.12260.04511InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.00044180.05363InformativeInherited
Biological Process (BP)vesicle-mediated transport0.055041InformativeInherited
Biological Process (BP)protein folding5.659e-060Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization4.001e-061.365e-07Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization3.695e-080.09406Highly InformativeInherited
Biological Process (BP)negative regulation of cell differentiation0.19981Highly InformativeInherited
Biological Process (BP)microtubule-based movement0.0054510Highly InformativeInherited
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.034660.7631Highly InformativeInherited
Biological Process (BP)Golgi vesicle transport0.0039460.1256Highly InformativeInherited
Biological Process (BP)protein glycosylation0.043660.06248Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity11Moderately InformativeInherited
Cellular Component (CC)protein complex7.508e-075.342e-06Least InformativeDirect
Cellular Component (CC)intracellular organelle part1.551e-075.301e-05Least InformativeDirect
Cellular Component (CC)membrane0.49021Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.31630.9498Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.089421.775e-05Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.054230.001247Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.016170.3507Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.00012890.8465Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.00014130.7274Moderately InformativeInherited
Cellular Component (CC)intrinsic to membrane0.1411Moderately InformativeInherited
Cellular Component (CC)vesicle0.10021Moderately InformativeInherited
Cellular Component (CC)cell projection0.70152.208e-08Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.71870.5306Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.28720.9694Moderately InformativeInherited
Cellular Component (CC)mitochondrial part0.53151Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane6.873e-050.07103InformativeInherited
Cellular Component (CC)mitochondrial membrane part0.031380.2InformativeInherited
Cellular Component (CC)integral to membrane0.37261InformativeInherited
Cellular Component (CC)Golgi apparatus0.036741InformativeInherited
Cellular Component (CC)coated vesicle0.010310.4657InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.0017340.001668InformativeInherited
Cellular Component (CC)Golgi-associated vesicle2.874e-074.564e-06Highly InformativeDirect
Cellular Component (CC)intraflagellar transport particle0.00044930Highly InformativeDirect
Cellular Component (CC)intrinsic to organelle membrane1.853e-115.392e-05Highly InformativeDirect
Cellular Component (CC)organelle outer membrane9.313e-084.618e-08Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 1.667e-08 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 6.927e-12 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1.933e-09 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.6548 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9913 Least Informative Inherited
Biological Process (BP) organelle organization 3.77e-15 Moderately Informative Direct
Biological Process (BP) macromolecule localization 1.623e-06 Moderately Informative Direct
Biological Process (BP) cellular localization 8.429e-10 Moderately Informative Direct
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.03081 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2276 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.3739 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2804 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9752 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.7593 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) protein complex assembly 0.0004246 Informative Direct
Biological Process (BP) cellular component movement 0.0001968 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) protein transport 0.0001533 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 7.197e-05 Informative Direct
Biological Process (BP) cell projection organization 7.658e-05 Informative Direct
Biological Process (BP) regulation of organelle organization 1.312e-05 Informative Direct
Biological Process (BP) protein localization to organelle 1.826e-07 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 2.287e-06 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 2.595e-06 Informative Direct
Biological Process (BP) organelle assembly 8.204e-06 Informative Direct
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) muscle system process 0.6412 Informative Inherited
Biological Process (BP) tube development 0.2419 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.006109 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.005868 Informative Inherited
Biological Process (BP) actin filament-based process 0.402 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.3986 Informative Inherited
Biological Process (BP) blood circulation 0.6114 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.01465 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.1015 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.13 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.05363 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.2643 Informative Inherited
Biological Process (BP) muscle structure development 0.4367 Informative Inherited
Biological Process (BP) muscle tissue development 0.1976 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.4171 Informative Inherited
Biological Process (BP) mitochondrion organization 0.0551 Informative Inherited
Biological Process (BP) chromosome organization 0.3156 Informative Inherited
Biological Process (BP) cell cycle process 0.001736 Informative Inherited
Biological Process (BP) RNA processing 0.1083 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.9748 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.4053 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.3753 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.04511 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9298 Informative Inherited
Biological Process (BP) sexual reproduction 0.5744 Informative Inherited
Biological Process (BP) single organism reproductive process 0.5365 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.8133 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1367 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1825 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.04795 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.308 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) protein methylation 0.0005244 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 3.172e-07 Highly Informative Direct
Biological Process (BP) mitochondrial transport 5.711e-08 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) chromosome segregation 2.118e-05 Highly Informative Direct
Biological Process (BP) mitosis 2.193e-05 Highly Informative Direct
Biological Process (BP) regulation of mitosis 5.804e-07 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 1.365e-07 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 3.77e-15 Highly Informative Direct
Biological Process (BP) gene silencing 0.0001155 Highly Informative Direct
Biological Process (BP) protein import 0.0005693 Highly Informative Direct
Biological Process (BP) peptidyl-proline modification 0 Highly Informative Direct
Biological Process (BP) cell projection assembly 1.055e-09 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 4.722e-06 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 5.739e-08 Highly Informative Direct
Biological Process (BP) cilium organization 0 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0001146 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 6.999e-05 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.0006118 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 1.16e-07 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.06979 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.03862 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.5342 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.7164 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.09406 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.008331 Highly Informative Inherited
Biological Process (BP) heart contraction 0.004479 Highly Informative Inherited
Biological Process (BP) renal system development 0.0778 Highly Informative Inherited
Biological Process (BP) response to ionizing radiation 0.9273 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.01604 Highly Informative Inherited
Biological Process (BP) spindle checkpoint 0.001824 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 1 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.05241 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 0.1115 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.01577 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.001487 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.003452 Highly Informative Inherited
Biological Process (BP) histone modification 0.1712 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.8608 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.1636 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.3517 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.002048 Highly Informative Inherited
Biological Process (BP) DNA replication 0.02105 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.0767 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.005753 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.7631 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1422 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.02024 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.02314 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.1256 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.06248 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.007569 Highly Informative Inherited
Biological Process (BP) mRNA catabolic process 0.01253 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.0002348 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.9712 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.7291 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.001286 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.6386 Informative Inherited
Molecular Function (MF) enzyme binding 0.2063 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.004518 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.06183 Informative Inherited
Molecular Function (MF) amide binding 0.002599 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 1.076e-08 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 1.563e-15 Highly Informative Direct
Molecular Function (MF) adenylyltransferase activity 7.468e-12 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 0.03472 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.003255 Highly Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0.03426 Highly Informative Inherited
Molecular Function (MF) methyltransferase activity 0.9717 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.3245 Highly Informative Inherited
Molecular Function (MF) protein transporter activity 0.009412 Highly Informative Inherited
Molecular Function (MF) drug binding 0.003245 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.321 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.5102 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.001312 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1.775e-05 Least Informative Direct
Cellular Component (CC) protein complex 5.342e-06 Least Informative Direct
Cellular Component (CC) intracellular organelle part 5.301e-05 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.001247 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9498 Least Informative Inherited
Cellular Component (CC) cell projection 2.208e-08 Moderately Informative Direct
Cellular Component (CC) nuclear part 3.261e-08 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.8465 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.5306 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.7274 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.3507 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.9694 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.7674 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 8.462e-13 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.07103 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microbody 0.03208 Informative Inherited
Cellular Component (CC) mitochondrial membrane part 0.2 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) coated vesicle 0.4657 Informative Inherited
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 0.7429 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.001668 Informative Inherited
Cellular Component (CC) chromosome 0.07388 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) Golgi-associated vesicle 4.564e-06 Highly Informative Direct
Cellular Component (CC) intraflagellar transport particle 0 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 5.392e-05 Highly Informative Direct
Cellular Component (CC) organelle outer membrane 4.618e-08 Highly Informative Direct
Cellular Component (CC) cilium part 4.007e-13 Highly Informative Direct
Cellular Component (CC) spindle 0.3467 Highly Informative Inherited
Cellular Component (CC) growth cone 0.3224 Highly Informative Inherited
Cellular Component (CC) chromatin 0.01111 Highly Informative Inherited
Cellular Component (CC) microtubule associated complex 0.7579 Highly Informative Inherited
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0.02104 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited
Cellular Component (CC) centrosome 0.1563 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase4.361e-12InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase7.897e-09InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7188Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.3548InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0002753Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.002537Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.008862Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2983Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.000198Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of digit0.0958Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genital system0.1243Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.2747Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.0003138InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the fundus0.005876InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral ventricles0.05508InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.1056InformativeInherited
Phenotypic Abnormality (PA)Postaxial polydactyly0.0001773Highly InformativeDirect
Phenotypic Abnormality (PA)Cataract0.0002876Highly InformativeDirect
Phenotypic Abnormality (PA)Ventriculomegaly0.0007367Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.4354Least InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.1549Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.002709InformativeInherited
Mammalian Phenotype (MP)abnormal primary cilium morphology0.08669Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.002705Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.007132Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.05727Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0001758Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0005997Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.02152Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.02421Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.109Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant1.182e-07InformativeDirect
Worm Phenotype (WP)chemotaxis variant2.538e-05InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0001813InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.003694InformativeInherited
Worm Phenotype (WP)male morphology variant0.007713InformativeInherited
Worm Phenotype (WP)copulation variant0.02665InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)mitotic spindle defective early emb9.735e-06Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0003135Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0003952Highly InformativeDirect
Worm Phenotype (WP)nuclear number variant0.0007523Highly InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant0.0008091Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.001248Highly InformativeInherited
Worm Phenotype (WP)cell cycle variant0.00489Highly InformativeInherited
Worm Phenotype (WP)touch resistant0.1792Highly InformativeInherited

Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed1.344e-08Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.04157Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1729Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage4.524e-05Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.0006744Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.1084Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0009304Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.002551Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.004645Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3573Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5508Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase2.272e-12InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase2.543e-06InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.004544InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase4.357e-09Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase7.093e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processCell cycle3.004e-15Moderately InformativeDirect
Biological processDifferentiation1.081e-11Moderately InformativeDirect
Biological processApoptosis4.313e-05Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processNeurogenesis1.371e-07InformativeDirect
Biological processInnate immunity1.233e-06InformativeDirect
Biological processMeiosis2.763e-05InformativeDirect
Biological processmRNA splicing7.52e-05InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Biological processRNA-mediated gene silencing4.889e-12Highly InformativeDirect
Biological processChromosome partition7.377e-09Highly InformativeDirect
Biological processNonsense-mediated mRNA decay1.028e-07Highly InformativeDirect
Biological processAntiviral defense7.047e-07Highly InformativeDirect
Biological processUnfolded protein response2.963e-06Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentMitochondrion6.306e-15Moderately InformativeDirect
Cellular componentEndoplasmic reticulum2.037e-05Moderately InformativeDirect
Cellular componentCytoplasmic vesicle2.648e-05Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSpliceosome0InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeroxisome1.796e-12InformativeDirect
Cellular componentCell outer membrane4.188e-06InformativeDirect
Cellular componentCilium0Highly InformativeDirect
Cellular componentProteasome3.791e-05Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0006215Least InformativeDirect
DiseaseCiliopathy6.19e-09InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTPR repeat0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationActivator8.903e-08Moderately InformativeDirect
Post-translational modificationIsomerase0.7965Moderately InformativeInherited
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationChaperone1.532e-07InformativeDirect
Post-translational modificationProtein phosphatase4.148e-07InformativeDirect
Post-translational modificationChromatin regulator4.076e-06InformativeDirect
Post-translational modificationInitiation factor6.737e-06InformativeDirect
Post-translational modificationRotamase0Highly InformativeDirect
Post-translational modificationDioxygenase2.69e-14Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation3.356e-05Moderately InformativeDirect
Post-translational modificationPalmitate0.000452Moderately InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)glycan metabolism8.806e-08Moderately InformativeDirect
UniPathway (UP)cellulose metabolism3.094e-12InformativeDirect
UniPathway (UP)bacterial cellulose biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]