SUPERFAMILY 1.75 HMM library and genome assignments server


TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (2,405) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 138,062 230,867 50
Proteins 100,822 177,223 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)localization0.59270.6743Least InformativeInherited
Biological Process (BP)single-organism cellular process0.9370.4785Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0030445.211e-07Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)protein metabolic process11.981e-11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process15.966e-15Least InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process11Moderately InformativeInherited
Biological Process (BP)nervous system development0.33531Moderately InformativeInherited
Biological Process (BP)cell differentiation0.72171Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.85571Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0036932.427e-06Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.15530.9266Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.32010.6309Moderately InformativeInherited
Biological Process (BP)organelle organization0.011332.647e-07Moderately InformativeInherited
Biological Process (BP)cellular localization0.0035573.103e-08Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process10.4368Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)negative regulation of developmental process0.22581InformativeInherited
Biological Process (BP)regulation of cell development0.49561InformativeInherited
Biological Process (BP)generation of neurons0.19481InformativeInherited
Biological Process (BP)regulation of nervous system development0.21181InformativeInherited
Biological Process (BP)cell projection organization0.05420.0007297InformativeInherited
Biological Process (BP)vesicle-mediated transport0.038920.9677InformativeInherited
Biological Process (BP)cellular component disassembly0.0046350.5874InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.42941InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.11210.02779InformativeInherited
Biological Process (BP)protein folding4.62e-066.117e-14Highly InformativeDirect
Biological Process (BP)regulation of neuron differentiation0.091950.6501Highly InformativeInherited
Biological Process (BP)cellular protein complex disassembly10.0101Highly InformativeInherited
Biological Process (BP)negative regulation of cell development0.0058710.01018Highly InformativeInherited
Biological Process (BP)regulation of cell morphogenesis0.21480.4202Highly InformativeInherited
Biological Process (BP)Golgi vesicle transport0.0033390.05422Highly InformativeInherited
Biological Process (BP)protein glycosylation0.037440.0576Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity11Moderately InformativeInherited
Molecular Function (MF)protein binding0.11020.2262Moderately InformativeInherited
Molecular Function (MF)macromolecule transmembrane transporter activity0.00070480.0009856Highly InformativeDirect
Cellular Component (CC)protein complex4.564e-060.0001481Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.00023820.0003332Least InformativeDirect
Cellular Component (CC)membrane0.45581Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.12330.9776Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.55048.505e-05Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.0083790.6975Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.0012271Moderately InformativeInherited
Cellular Component (CC)intrinsic to membrane0.44681Moderately InformativeInherited
Cellular Component (CC)vesicle0.0080130.7119Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.20650.887Moderately InformativeInherited
Cellular Component (CC)mitochondrial part0.43041Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.00022810.8419Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane5.818e-050.07227InformativeInherited
Cellular Component (CC)microbody0.0025750.01931InformativeInherited
Cellular Component (CC)mitochondrial membrane part0.06290.248InformativeInherited
Cellular Component (CC)integral to membrane0.01011InformativeInherited
Cellular Component (CC)Golgi apparatus0.13811InformativeInherited
Cellular Component (CC)coated vesicle0.0080510.4345InformativeInherited
Cellular Component (CC)mitochondrial outer membrane3.53e-081.089e-08Highly InformativeDirect
Cellular Component (CC)Golgi-associated vesicle1.054e-061.85e-05Highly InformativeDirect
Cellular Component (CC)SNARE complex9.106e-141.263e-05Highly InformativeDirect
Cellular Component (CC)intrinsic to endoplasmic reticulum membrane4.078e-071.595e-05Highly InformativeDirect
Cellular Component (CC)integral to organelle membrane8.293e-147.102e-07Highly InformativeDirect
Cellular Component (CC)microbody part0.00066380.0002087Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 1.981e-11 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 5.966e-15 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 5.211e-07 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.6743 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4785 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 2.647e-07 Moderately Informative Direct
Biological Process (BP) macromolecule localization 2.427e-06 Moderately Informative Direct
Biological Process (BP) cellular localization 3.103e-08 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.8586 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9266 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.5634 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4368 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.6309 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8456 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.7805 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5611 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0.0002442 Informative Direct
Biological Process (BP) microtubule-based process 1.835e-11 Informative Direct
Biological Process (BP) protein transport 0.0002574 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 2.357e-13 Informative Direct
Biological Process (BP) cell projection organization 0.0007297 Informative Direct
Biological Process (BP) protein localization to organelle 6.145e-07 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 7.406e-07 Informative Direct
Biological Process (BP) muscle system process 0.5481 Informative Inherited
Biological Process (BP) tube development 0.5587 Informative Inherited
Biological Process (BP) transmembrane transport 0.9553 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.005103 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.002121 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.1214 Informative Inherited
Biological Process (BP) blood circulation 0.5233 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.9714 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.8699 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.005731 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.5742 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.8083 Informative Inherited
Biological Process (BP) muscle tissue development 0.8699 Informative Inherited
Biological Process (BP) muscle structure development 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.9677 Informative Inherited
Biological Process (BP) cellular component disassembly 0.5874 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.219 Informative Inherited
Biological Process (BP) mitochondrion organization 0.001832 Informative Inherited
Biological Process (BP) chromosome organization 0.004653 Informative Inherited
Biological Process (BP) cell cycle process 0.0102 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.001315 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.4928 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.02779 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.686 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3711 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.02924 Informative Inherited
Biological Process (BP) proteolysis 0.944 Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.6248 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.4351 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.6482 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.3856 Informative Inherited
Biological Process (BP) translational initiation 0.0009654 Highly Informative Direct
Biological Process (BP) protein folding 6.117e-14 Highly Informative Direct
Biological Process (BP) protein methylation 1.612e-07 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 0.0007754 Highly Informative Direct
Biological Process (BP) mitochondrial transport 1.674e-08 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) chromosome segregation 9.834e-06 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 4.61e-08 Highly Informative Direct
Biological Process (BP) protein import 0.0006388 Highly Informative Direct
Biological Process (BP) peptidyl-proline modification 0 Highly Informative Direct
Biological Process (BP) cell projection assembly 1.158e-10 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 1.223e-07 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 6.078e-05 Highly Informative Direct
Biological Process (BP) maintenance of location 4.688e-05 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 5.996e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.03664 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.003742 Highly Informative Inherited
Biological Process (BP) heart contraction 0.001649 Highly Informative Inherited
Biological Process (BP) spindle checkpoint 0.001521 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle checkpoint 0.2218 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.07401 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 0.06698 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.00741 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.121 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.002392 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 0.4202 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle 0.9674 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.2592 Highly Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.1272 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 0.6501 Highly Informative Inherited
Biological Process (BP) DNA replication 0.007685 Highly Informative Inherited
Biological Process (BP) histone modification 0.2446 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 1 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.9627 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.7717 Highly Informative Inherited
Biological Process (BP) cellular protein complex disassembly 0.0101 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.05598 Highly Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.5755 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.1292 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.01018 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1367 Highly Informative Inherited
Biological Process (BP) nuclear division 1 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.05422 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to mitochondrion 0.03729 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.004225 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.0576 Highly Informative Inherited
Biological Process (BP) RNA splicing, via transesterification reactions 0.07273 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 1.285e-10 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.2262 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.0009655 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.00173 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.7329 Informative Inherited
Molecular Function (MF) enzyme binding 0.02753 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.5946 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) drug binding 2.014e-12 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 1.342e-08 Highly Informative Direct
Molecular Function (MF) macromolecule transmembrane transporter activity 0.0009856 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 1.562e-15 Highly Informative Direct
Molecular Function (MF) adenylyltransferase activity 1.414e-11 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0.02697 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.004248 Highly Informative Inherited
Molecular Function (MF) methyltransferase activity 0.9255 Highly Informative Inherited
Molecular Function (MF) UDP-glycosyltransferase activity 0.01946 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.2342 Highly Informative Inherited
Molecular Function (MF) protein transporter activity 0.007832 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.5276 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.005574 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 8.505e-05 Least Informative Direct
Cellular Component (CC) protein complex 0.0001481 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0003332 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.08251 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9776 Least Informative Inherited
Cellular Component (CC) cell projection 3.865e-07 Moderately Informative Direct
Cellular Component (CC) nuclear part 4.532e-05 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.6975 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.05955 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.7119 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.887 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.8419 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 3.112e-13 Informative Direct
Cellular Component (CC) cell projection part 2.365e-11 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.07227 Informative Inherited
Cellular Component (CC) neuron part 0.2028 Informative Inherited
Cellular Component (CC) chromosome 0.1065 Informative Inherited
Cellular Component (CC) microbody 0.01931 Informative Inherited
Cellular Component (CC) mitochondrial membrane part 0.248 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) coated vesicle 0.4345 Informative Inherited
Cellular Component (CC) DNA-directed RNA polymerase complex 0.1744 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.006507 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) mitochondrial outer membrane 1.089e-08 Highly Informative Direct
Cellular Component (CC) Golgi-associated vesicle 1.85e-05 Highly Informative Direct
Cellular Component (CC) transcription elongation factor complex 8.377e-07 Highly Informative Direct
Cellular Component (CC) CCR4-NOT complex 6.57e-08 Highly Informative Direct
Cellular Component (CC) SNARE complex 1.263e-05 Highly Informative Direct
Cellular Component (CC) intrinsic to endoplasmic reticulum membrane 1.595e-05 Highly Informative Direct
Cellular Component (CC) integral to organelle membrane 7.102e-07 Highly Informative Direct
Cellular Component (CC) microbody membrane 0.0002368 Highly Informative Direct
Cellular Component (CC) microbody part 0.0002087 Highly Informative Direct
Cellular Component (CC) cilium part 0 Highly Informative Direct
Cellular Component (CC) spindle 0.3685 Highly Informative Inherited
Cellular Component (CC) growth cone 0.8217 Highly Informative Inherited
Cellular Component (CC) axon part 1 Highly Informative Inherited
Cellular Component (CC) chromatin 0.00892 Highly Informative Inherited
Cellular Component (CC) nonmotile primary cilium 1 Highly Informative Inherited
Cellular Component (CC) proteasome complex 0.002767 Highly Informative Inherited
Cellular Component (CC) microtubule associated complex 0.6712 Highly Informative Inherited
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0.02629 Highly Informative Inherited
Cellular Component (CC) replisome 0.01341 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 0.002772 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase4.361e-12InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase7.897e-09InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7792Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.4122InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0004113Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.002788Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.009094Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the central nervous system0.08446Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the eye0.05255Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digits0.0783Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genital system0.1092Moderately InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the central nervous system0.2092Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.0001927InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the retina0.0004663InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lens0.1013InformativeInherited
Phenotypic Abnormality (PA)Postaxial polydactyly0.0002289Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral ventricles0.046Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)renal/urinary system phenotype0.0662Moderately InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.002705Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.007132Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.05727Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0001758Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0005997Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.02152Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.02421Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.109Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant1.182e-07InformativeDirect
Worm Phenotype (WP)chemotaxis variant2.538e-05InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0001813InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.003694InformativeInherited
Worm Phenotype (WP)male morphology variant0.007713InformativeInherited
Worm Phenotype (WP)copulation variant0.02665InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)mitotic spindle defective early emb9.735e-06Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0003135Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0003952Highly InformativeDirect
Worm Phenotype (WP)nuclear number variant0.0007523Highly InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant0.0008091Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.001248Highly InformativeInherited
Worm Phenotype (WP)cell cycle variant0.00489Highly InformativeInherited
Worm Phenotype (WP)touch resistant0.1792Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed7.263e-14Least InformativeDirect
Plant ANatomical entity (PAN)shoot apex1.126e-10Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo1.223e-05Least InformativeDirect
Plant ANatomical entity (PAN)pedicel0.0004517Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage5.293e-05Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.001641Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.14Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.001209Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002771Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003528Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3989Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5553Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase3.628e-12InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase4.352e-06InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.005948InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase7.267e-09Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase8.184e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

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DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)vitamins0.0003054Least InformativeDirect
Drugbank ATC_code (DB)genito urinary system and sex hormones0.0001779Moderately InformativeDirect
Drugbank ATC_code (DB)other ophthalmologicals1Moderately InformativeInherited
Drugbank ATC_code (DB)ascorbic acid (vitamin c), incl. combinations1.825e-06InformativeDirect
Drugbank ATC_code (DB)ascorbic acid1.825e-06InformativeDirect
Drugbank ATC_code (DB)ascorbic acid1.825e-06InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processCell cycle6.917e-16Moderately InformativeDirect
Biological processDifferentiation1.673e-08Moderately InformativeDirect
Biological processApoptosis2.079e-05Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processNeurogenesis4.613e-08InformativeDirect
Biological processInnate immunity2.591e-07InformativeDirect
Biological processInitiation factor5.603e-06InformativeDirect
Biological processmRNA splicing0.0001045InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Biological processChromosome partition4.895e-09Highly InformativeDirect
Biological processAntiviral defense2.707e-07Highly InformativeDirect
Biological processUnfolded protein response1.243e-06Highly InformativeDirect
Biological processNonsense-mediated mRNA decay1.325e-06Highly InformativeDirect
Biological processSpliceosome1.838e-05Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum4.184e-06Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0004539Moderately InformativeDirect
Cellular componentGolgi apparatus0.000636Moderately InformativeDirect
Cellular componentCell membrane1Moderately InformativeInherited
Cellular componentMicrotubule0InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeroxisome4.401e-11InformativeDirect
Cellular componentCell outer membrane1.793e-09InformativeDirect
Cellular componentChromosome0.1258InformativeInherited
Cellular componentCilium0Highly InformativeDirect
Cellular componentProteasome2.809e-05Highly InformativeDirect
Cellular componentTelomere0.0001798Highly InformativeDirect
DiseaseDisease mutation0.0004145Least InformativeDirect
DiseaseCiliopathy5.214e-06InformativeDirect
DiseaseMental retardation0.0001754Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTPR repeat0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationActivator3.499e-08Moderately InformativeDirect
Post-translational modificationIsomerase0.4007Moderately InformativeInherited
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationRibonucleoprotein1Moderately InformativeInherited
Post-translational modificationProtein phosphatase2.981e-07InformativeDirect
Post-translational modificationChaperone2.179e-06InformativeDirect
Post-translational modificationChromatin regulator2.249e-06InformativeDirect
Post-translational modificationRotamase0Highly InformativeDirect
Post-translational modificationDioxygenase7.625e-15Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation6.316e-06Moderately InformativeDirect
Post-translational modificationPalmitate0.0008633Moderately InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)glycan metabolism1.408e-06Moderately InformativeDirect
UniPathway (UP)cellulose metabolism6.91e-14InformativeDirect
UniPathway (UP)cellulose biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]