SUPERFAMILY 1.75 HMM library and genome assignments server


TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,123) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 167,358 406,918 50
Proteins 123,616 317,615 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)localization0.3520.549Least InformativeInherited
Biological Process (BP)single-organism cellular process0.95691Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0017036.23e-10Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)protein metabolic process18.95e-09Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process14.123e-12Least InformativeInherited
Biological Process (BP)cellular localization0.00033079.328e-10Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.10481Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)nervous system development0.39421Moderately InformativeInherited
Biological Process (BP)cell differentiation0.85671Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process11Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0027131.578e-06Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0046830.2502Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.94741Moderately InformativeInherited
Biological Process (BP)organelle organization0.003463.741e-15Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of developmental process0.0069261InformativeInherited
Biological Process (BP)regulation of organelle organization0.0029852.012e-05InformativeInherited
Biological Process (BP)negative regulation of developmental process0.33031InformativeInherited
Biological Process (BP)regulation of cell development0.39121InformativeInherited
Biological Process (BP)generation of neurons0.14021InformativeInherited
Biological Process (BP)regulation of nervous system development0.2821InformativeInherited
Biological Process (BP)cell projection organization0.0041020.0001071InformativeInherited
Biological Process (BP)cellular component movement0.11660.0001862InformativeInherited
Biological Process (BP)microtubule-based process0.03990InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.00023281InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.12730.04707InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.00049180.05793InformativeInherited
Biological Process (BP)vesicle-mediated transport0.05741InformativeInherited
Biological Process (BP)protein folding5.987e-060Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization4.503e-062.035e-07Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization3.842e-080.08626Highly InformativeInherited
Biological Process (BP)negative regulation of cell differentiation0.20041Highly InformativeInherited
Biological Process (BP)microtubule-based movement0.0049970Highly InformativeInherited
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.034740.7548Highly InformativeInherited
Biological Process (BP)Golgi vesicle transport0.0039980.1305Highly InformativeInherited
Biological Process (BP)protein glycosylation0.044860.0639Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity11Moderately InformativeInherited
Cellular Component (CC)protein complex8.418e-075.147e-06Least InformativeDirect
Cellular Component (CC)intracellular organelle part1.577e-073.816e-05Least InformativeDirect
Cellular Component (CC)membrane0.48491Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.091099.11e-06Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.3210.9329Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.053760.001306Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.01590.2999Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.00011950.8335Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.00013910.7075Moderately InformativeInherited
Cellular Component (CC)intrinsic to membrane0.13591Moderately InformativeInherited
Cellular Component (CC)vesicle0.10211Moderately InformativeInherited
Cellular Component (CC)cell projection0.71663.662e-08Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.71730.6012Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.28810.9664Moderately InformativeInherited
Cellular Component (CC)mitochondrial part0.53361Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane5.97e-050.06744InformativeInherited
Cellular Component (CC)mitochondrial membrane part0.03170.1959InformativeInherited
Cellular Component (CC)integral to membrane0.36791InformativeInherited
Cellular Component (CC)Golgi apparatus0.036941InformativeInherited
Cellular Component (CC)coated vesicle0.011110.4794InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.0016260.0009727InformativeInherited
Cellular Component (CC)Golgi-associated vesicle2.821e-074.421e-06Highly InformativeDirect
Cellular Component (CC)intraflagellar transport particle0.00044080Highly InformativeDirect
Cellular Component (CC)intrinsic to organelle membrane1.332e-115.344e-05Highly InformativeDirect
Cellular Component (CC)organelle outer membrane9.327e-084.406e-08Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 8.95e-09 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 4.123e-12 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 6.23e-10 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.549 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organelle organization 3.741e-15 Moderately Informative Direct
Biological Process (BP) macromolecule localization 1.578e-06 Moderately Informative Direct
Biological Process (BP) cellular localization 9.328e-10 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.03019 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2532 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.3651 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2502 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9747 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.769 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0.0001862 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) protein transport 0.0001724 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.00011 Informative Direct
Biological Process (BP) cell projection organization 0.0001071 Informative Direct
Biological Process (BP) regulation of organelle organization 2.012e-05 Informative Direct
Biological Process (BP) protein localization to organelle 1.613e-07 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 2.298e-06 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 3.339e-06 Informative Direct
Biological Process (BP) organelle assembly 8.435e-06 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.8467 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) muscle system process 0.6502 Informative Inherited
Biological Process (BP) tube development 0.2318 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.006081 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.006169 Informative Inherited
Biological Process (BP) actin filament-based process 0.4033 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.4418 Informative Inherited
Biological Process (BP) blood circulation 0.6135 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.0139 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.1024 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.1244 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.05793 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.2911 Informative Inherited
Biological Process (BP) muscle structure development 0.4292 Informative Inherited
Biological Process (BP) muscle tissue development 0.1929 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.4375 Informative Inherited
Biological Process (BP) mitochondrion organization 0.05436 Informative Inherited
Biological Process (BP) chromosome organization 0.3172 Informative Inherited
Biological Process (BP) cell cycle process 0.001056 Informative Inherited
Biological Process (BP) RNA processing 0.1062 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.9948 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.4206 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.3779 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.04707 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9178 Informative Inherited
Biological Process (BP) sexual reproduction 0.554 Informative Inherited
Biological Process (BP) single organism reproductive process 0.5245 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.802 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1304 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1771 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.05542 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.3328 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) protein methylation 0.0005274 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 3.458e-07 Highly Informative Direct
Biological Process (BP) mitochondrial transport 5.7e-08 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) chromosome segregation 2.037e-05 Highly Informative Direct
Biological Process (BP) mitosis 3.229e-05 Highly Informative Direct
Biological Process (BP) regulation of mitosis 5.695e-07 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 2.035e-07 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 3.741e-15 Highly Informative Direct
Biological Process (BP) gene silencing 0.0001136 Highly Informative Direct
Biological Process (BP) protein import 0.000596 Highly Informative Direct
Biological Process (BP) peptidyl-proline modification 0 Highly Informative Direct
Biological Process (BP) cell projection assembly 1.072e-09 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 5.161e-06 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 6.268e-08 Highly Informative Direct
Biological Process (BP) cilium organization 0 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0001145 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 1.562e-05 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.0006637 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 1.041e-07 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.07012 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.04186 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.6169 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.784 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.08626 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.009846 Highly Informative Inherited
Biological Process (BP) heart contraction 0.004982 Highly Informative Inherited
Biological Process (BP) renal system development 0.0764 Highly Informative Inherited
Biological Process (BP) response to ionizing radiation 0.9251 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.01262 Highly Informative Inherited
Biological Process (BP) spindle checkpoint 0.001826 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 1 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.05298 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 0.111 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.01641 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.00133 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.003383 Highly Informative Inherited
Biological Process (BP) histone modification 0.1915 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.8605 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.03971 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.3779 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.002023 Highly Informative Inherited
Biological Process (BP) DNA replication 0.0212 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.07566 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.005891 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.7548 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1342 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.01949 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.02169 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.1305 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.0639 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.007063 Highly Informative Inherited
Biological Process (BP) mRNA catabolic process 0.01288 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.0003021 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.9568 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.7477 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.001469 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.6709 Informative Inherited
Molecular Function (MF) enzyme binding 0.2249 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.01015 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.06203 Informative Inherited
Molecular Function (MF) amide binding 0.002612 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 1.51e-08 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 1.557e-15 Highly Informative Direct
Molecular Function (MF) adenylyltransferase activity 1.07e-11 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 0.03539 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.003551 Highly Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0.03504 Highly Informative Inherited
Molecular Function (MF) methyltransferase activity 0.9822 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.3373 Highly Informative Inherited
Molecular Function (MF) protein transporter activity 0.008768 Highly Informative Inherited
Molecular Function (MF) drug binding 0.003341 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.3209 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.5122 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.00128 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 9.11e-06 Least Informative Direct
Cellular Component (CC) protein complex 5.147e-06 Least Informative Direct
Cellular Component (CC) intracellular organelle part 3.816e-05 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.001306 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9329 Least Informative Inherited
Cellular Component (CC) cell projection 3.662e-08 Moderately Informative Direct
Cellular Component (CC) nuclear part 1.422e-08 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.8335 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.6012 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.7075 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.2999 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.9664 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.719 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 1.151e-12 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0009727 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.06744 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microbody 0.03221 Informative Inherited
Cellular Component (CC) mitochondrial membrane part 0.1959 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) coated vesicle 0.4794 Informative Inherited
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 0.7552 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) chromosome 0.07364 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) Golgi-associated vesicle 4.421e-06 Highly Informative Direct
Cellular Component (CC) intraflagellar transport particle 0 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 5.344e-05 Highly Informative Direct
Cellular Component (CC) organelle outer membrane 4.406e-08 Highly Informative Direct
Cellular Component (CC) cilium part 4.826e-13 Highly Informative Direct
Cellular Component (CC) growth cone 0.3548 Highly Informative Inherited
Cellular Component (CC) chromatin 0.01119 Highly Informative Inherited
Cellular Component (CC) microtubule associated complex 0.7498 Highly Informative Inherited
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0.02074 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited
Cellular Component (CC) centrosome 0.1507 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase4.361e-12InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase7.897e-09InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7932Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.369InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0002923Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.00874Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.298Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.0002009Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of digit0.09255Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.2714Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.4228Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.0003509InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the fundus0.006294InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral ventricles0.05497InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.1025InformativeInherited
Phenotypic Abnormality (PA)Postaxial polydactyly0.0002039Highly InformativeDirect
Phenotypic Abnormality (PA)Cataract0.0002865Highly InformativeDirect
Phenotypic Abnormality (PA)Ventriculomegaly0.0007116Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.3662Least InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.1529Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.002891InformativeInherited
Mammalian Phenotype (MP)abnormal primary cilium morphology0.08636Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.002705Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.007132Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.05727Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0001758Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0005997Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.02152Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.02421Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.109Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant1.182e-07InformativeDirect
Worm Phenotype (WP)chemotaxis variant2.538e-05InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0001813InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.003694InformativeInherited
Worm Phenotype (WP)male morphology variant0.007713InformativeInherited
Worm Phenotype (WP)copulation variant0.02665InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)mitotic spindle defective early emb9.735e-06Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0003135Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0003952Highly InformativeDirect
Worm Phenotype (WP)nuclear number variant0.0007523Highly InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant0.0008091Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.001248Highly InformativeInherited
Worm Phenotype (WP)cell cycle variant0.00489Highly InformativeInherited
Worm Phenotype (WP)touch resistant0.1792Highly InformativeInherited

Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed1.344e-08Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.04157Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1729Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage4.524e-05Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.0006763Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.106Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0009292Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.002556Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.004597Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3581Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5504Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase2.261e-12InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase2.563e-06InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.004592InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase4.337e-09Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase7.086e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processCell cycle3.004e-15Moderately InformativeDirect
Biological processDifferentiation1.081e-11Moderately InformativeDirect
Biological processApoptosis4.313e-05Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processNeurogenesis1.371e-07InformativeDirect
Biological processInnate immunity1.233e-06InformativeDirect
Biological processMeiosis2.763e-05InformativeDirect
Biological processmRNA splicing7.52e-05InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Biological processRNA-mediated gene silencing4.889e-12Highly InformativeDirect
Biological processChromosome partition7.377e-09Highly InformativeDirect
Biological processNonsense-mediated mRNA decay1.028e-07Highly InformativeDirect
Biological processAntiviral defense7.047e-07Highly InformativeDirect
Biological processUnfolded protein response2.963e-06Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentMitochondrion6.306e-15Moderately InformativeDirect
Cellular componentEndoplasmic reticulum2.037e-05Moderately InformativeDirect
Cellular componentCytoplasmic vesicle2.648e-05Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSpliceosome0InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeroxisome1.796e-12InformativeDirect
Cellular componentCell outer membrane4.188e-06InformativeDirect
Cellular componentCilium0Highly InformativeDirect
Cellular componentProteasome3.791e-05Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0006215Least InformativeDirect
DiseaseCiliopathy6.19e-09InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTPR repeat0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationActivator8.903e-08Moderately InformativeDirect
Post-translational modificationIsomerase0.7965Moderately InformativeInherited
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationChaperone1.532e-07InformativeDirect
Post-translational modificationProtein phosphatase4.148e-07InformativeDirect
Post-translational modificationChromatin regulator4.076e-06InformativeDirect
Post-translational modificationInitiation factor6.737e-06InformativeDirect
Post-translational modificationRotamase0Highly InformativeDirect
Post-translational modificationDioxygenase2.69e-14Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation3.356e-05Moderately InformativeDirect
Post-translational modificationPalmitate0.000452Moderately InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)glycan metabolism4.495e-12Moderately InformativeDirect
UniPathway (UP)glycan biosynthesis0InformativeDirect
UniPathway (UP)cellulose metabolism8.257e-16InformativeDirect
UniPathway (UP)bacterial cellulose biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]