SUPERFAMILY 1.75 HMM library and genome assignments server


TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,083) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 155,117 230,867 50
Proteins 113,992 177,223 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.00050828.085e-09Least InformativeDirect
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.81450.931Least InformativeInherited
Biological Process (BP)localization0.32210.8108Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)protein metabolic process11.353e-09Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process12.353e-12Least InformativeInherited
Biological Process (BP)cellular localization0.00015971.127e-08Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.084141Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)nervous system development0.34111Moderately InformativeInherited
Biological Process (BP)cell differentiation0.76881Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.90571Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.27380.2469Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0017061.028e-06Moderately InformativeInherited
Biological Process (BP)organic substance transport0.61760.8492Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.001820.2013Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.88961Moderately InformativeInherited
Biological Process (BP)organelle organization0.0010522.741e-13Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process10.8368Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)protein transport0.00074349.246e-05InformativeDirect
Biological Process (BP)positive regulation of developmental process0.0060591InformativeInherited
Biological Process (BP)regulation of organelle organization0.0028311.375e-05InformativeInherited
Biological Process (BP)negative regulation of developmental process0.29961InformativeInherited
Biological Process (BP)regulation of cell development0.35741InformativeInherited
Biological Process (BP)generation of neurons0.211InformativeInherited
Biological Process (BP)regulation of nervous system development0.2411InformativeInherited
Biological Process (BP)cell projection organization0.0029372.751e-05InformativeInherited
Biological Process (BP)vesicle-mediated transport0.03051InformativeInherited
Biological Process (BP)cellular component movement0.098560.005575InformativeInherited
Biological Process (BP)microtubule-based process0.032630InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.00022280.9808InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.12790.07243InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.00038240.03252InformativeInherited
Biological Process (BP)protein folding3.689e-060Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization3.919e-064.822e-08Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization3.952e-080.1008Highly InformativeInherited
Biological Process (BP)negative regulation of cell differentiation0.20121Highly InformativeInherited
Biological Process (BP)cellular component disassembly0.0024030.4307Highly InformativeInherited
Biological Process (BP)microtubule-based movement0.0034470Highly InformativeInherited
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.030870.6856Highly InformativeInherited
Biological Process (BP)Golgi vesicle transport0.0048440.1022Highly InformativeInherited
Biological Process (BP)protein glycosylation0.042370.08942Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity11Moderately InformativeInherited
Cellular Component (CC)protein complex1.518e-062.865e-05Least InformativeDirect
Cellular Component (CC)membrane0.25481Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.00012910.005305Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.034241Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.24282.734e-05Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.67960.3176Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.011950.361Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.00015991Moderately InformativeInherited
Cellular Component (CC)organelle membrane6.491e-050.8963Moderately InformativeInherited
Cellular Component (CC)intrinsic to membrane0.21871Moderately InformativeInherited
Cellular Component (CC)vesicle0.01020.8627Moderately InformativeInherited
Cellular Component (CC)cell projection0.58265.376e-09Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.03550.01162Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.16110.8105Moderately InformativeInherited
Cellular Component (CC)mitochondrial part0.3821Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.00065960.0004633InformativeDirect
Cellular Component (CC)endoplasmic reticulum membrane3.919e-050.1211InformativeInherited
Cellular Component (CC)microbody0.0011640.02154InformativeInherited
Cellular Component (CC)mitochondrial membrane part0.029630.1801InformativeInherited
Cellular Component (CC)integral to membrane0.0057191InformativeInherited
Cellular Component (CC)Golgi apparatus0.077611InformativeInherited
Cellular Component (CC)coated vesicle0.0043850.4144InformativeInherited
Cellular Component (CC)mitochondrial outer membrane1.908e-099.973e-10Highly InformativeDirect
Cellular Component (CC)Golgi-associated vesicle1.097e-074.425e-06Highly InformativeDirect
Cellular Component (CC)intraflagellar transport particle B3.284e-052.229e-14Highly InformativeDirect
Cellular Component (CC)SNARE complex2.935e-120.0001184Highly InformativeDirect
Cellular Component (CC)intrinsic to organelle membrane1.235e-121.299e-05Highly InformativeDirect
Cellular Component (CC)microbody part0.00070473.98e-05Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 1.353e-09 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.353e-12 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 8.085e-09 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.8108 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.931 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 2.741e-13 Moderately Informative Direct
Biological Process (BP) macromolecule catabolic process 0.0002196 Moderately Informative Direct
Biological Process (BP) macromolecule localization 1.028e-06 Moderately Informative Direct
Biological Process (BP) cellular localization 1.127e-08 Moderately Informative Direct
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2875 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2469 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1474 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2013 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.8368 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8492 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.771 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) protein complex assembly 0.0003802 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) protein transport 9.246e-05 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 3.504e-07 Informative Direct
Biological Process (BP) cell projection organization 2.751e-05 Informative Direct
Biological Process (BP) regulation of organelle organization 1.375e-05 Informative Direct
Biological Process (BP) protein localization to organelle 7.663e-07 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 6.277e-06 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 2.345e-06 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.7801 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.1593 Informative Inherited
Biological Process (BP) cellular component movement 0.005575 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) blood circulation 0.5351 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.2861 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.1201 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.03252 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.8876 Informative Inherited
Biological Process (BP) organelle assembly 0.00228 Informative Inherited
Biological Process (BP) muscle tissue development 0.4583 Informative Inherited
Biological Process (BP) muscle structure development 0.7423 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.393 Informative Inherited
Biological Process (BP) mitochondrion organization 0.01779 Informative Inherited
Biological Process (BP) chromosome organization 0.1699 Informative Inherited
Biological Process (BP) cell cycle process 0.00124 Informative Inherited
Biological Process (BP) RNA processing 0.1527 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.3289 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.3122 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.9808 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.07243 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.9574 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.5591 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3614 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.04676 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) translation 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) RNA catabolic process 1.501e-07 Highly Informative Direct
Biological Process (BP) translational initiation 0.0009054 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) protein methylation 0.0003909 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 1.631e-07 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 0.0005481 Highly Informative Direct
Biological Process (BP) mitochondrial transport 2.81e-08 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) chromosome segregation 1.457e-05 Highly Informative Direct
Biological Process (BP) mitosis 7.407e-06 Highly Informative Direct
Biological Process (BP) regulation of mitosis 5.679e-07 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 4.822e-08 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 6.119e-09 Highly Informative Direct
Biological Process (BP) gene silencing 0.0002099 Highly Informative Direct
Biological Process (BP) protein import 0.0004165 Highly Informative Direct
Biological Process (BP) peptidyl-proline modification 0 Highly Informative Direct
Biological Process (BP) cell projection assembly 6.114e-11 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 8.421e-08 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 1.503e-07 Highly Informative Direct
Biological Process (BP) collagen metabolic process 0.0005687 Highly Informative Direct
Biological Process (BP) maintenance of location 6.358e-05 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 6.006e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.05715 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.0279 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.4818 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.6629 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.1008 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.004794 Highly Informative Inherited
Biological Process (BP) heart contraction 0.002112 Highly Informative Inherited
Biological Process (BP) renal system development 0.5923 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 1 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.163 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.06235 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 0.06197 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.006527 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.008971 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) DNA replication 0.01909 Highly Informative Inherited
Biological Process (BP) histone modification 0.2247 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 1 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.9496 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.003146 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.6852 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.4307 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.0851 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.007098 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.6856 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.3566 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1581 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.3529 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.1022 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to mitochondrion 0.02782 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.08942 Highly Informative Inherited
Biological Process (BP) tissue homeostasis 0.2824 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.006884 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.5665 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.0001428 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.0008938 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.6829 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.003576 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.5976 Informative Inherited
Molecular Function (MF) enzyme binding 0.09494 Informative Inherited
Molecular Function (MF) amide binding 0.001351 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.1493 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 7.065e-09 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0006473 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 1.555e-15 Highly Informative Direct
Molecular Function (MF) adenylyltransferase activity 5.023e-12 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 0.02919 Highly Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0.03345 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.002849 Highly Informative Inherited
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.6315 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.2953 Highly Informative Inherited
Molecular Function (MF) protein transporter activity 0.00915 Highly Informative Inherited
Molecular Function (MF) drug binding 0.003462 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.3085 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.4387 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 2.734e-05 Least Informative Direct
Cellular Component (CC) protein complex 2.865e-05 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.3176 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.005305 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cell projection 5.376e-09 Moderately Informative Direct
Cellular Component (CC) nuclear part 3.104e-05 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.01162 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.8963 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.8627 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.361 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.8105 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 1.924e-13 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0004633 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.1211 Informative Inherited
Cellular Component (CC) microbody 0.02154 Informative Inherited
Cellular Component (CC) mitochondrial membrane part 0.1801 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) coated vesicle 0.4144 Informative Inherited
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 0.5825 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) chromosome 0.01417 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) proteasome complex 1.838e-05 Highly Informative Direct
Cellular Component (CC) mitochondrial outer membrane 9.973e-10 Highly Informative Direct
Cellular Component (CC) Golgi-associated vesicle 4.425e-06 Highly Informative Direct
Cellular Component (CC) cilium 0 Highly Informative Direct
Cellular Component (CC) transcription elongation factor complex 5.212e-06 Highly Informative Direct
Cellular Component (CC) intraflagellar transport particle B 2.229e-14 Highly Informative Direct
Cellular Component (CC) SNARE complex 0.0001184 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 1.299e-05 Highly Informative Direct
Cellular Component (CC) N-terminal protein acetyltransferase complex 7.326e-07 Highly Informative Direct
Cellular Component (CC) microbody membrane 3.572e-05 Highly Informative Direct
Cellular Component (CC) microbody part 3.98e-05 Highly Informative Direct
Cellular Component (CC) spindle 0.1692 Highly Informative Inherited
Cellular Component (CC) chromatin 0.05255 Highly Informative Inherited
Cellular Component (CC) microtubule associated complex 0.6946 Highly Informative Inherited
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0.02316 Highly Informative Inherited
Cellular Component (CC) replisome 0.01553 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited
Cellular Component (CC) condensed chromosome 0.5361 Highly Informative Inherited
Cellular Component (CC) centrosome 0.01139 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center part 0.009932 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase4.361e-12InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase7.897e-09InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7312Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.3719InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0003376Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.01335Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2996Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.0002109Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digits0.09089Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.2763Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.4237Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.0002158InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the fundus0.006123InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral ventricles0.05484InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.1083InformativeInherited
Phenotypic Abnormality (PA)Postaxial polydactyly0.0002034Highly InformativeDirect
Phenotypic Abnormality (PA)Ventriculomegaly0.0007541Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)renal/urinary system phenotype0.1539Moderately InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.002705Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.007132Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.05727Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0001758Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0005997Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.02152Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.02421Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.109Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant1.182e-07InformativeDirect
Worm Phenotype (WP)chemotaxis variant2.538e-05InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0001813InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.003694InformativeInherited
Worm Phenotype (WP)male morphology variant0.007713InformativeInherited
Worm Phenotype (WP)copulation variant0.02665InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)mitotic spindle defective early emb9.735e-06Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0003135Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0003952Highly InformativeDirect
Worm Phenotype (WP)nuclear number variant0.0007523Highly InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant0.0008091Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.001248Highly InformativeInherited
Worm Phenotype (WP)cell cycle variant0.00489Highly InformativeInherited
Worm Phenotype (WP)touch resistant0.1792Highly InformativeInherited

Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed1.344e-08Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.04157Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1729Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage4.524e-05Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.001233Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1424Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.001166Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002574Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.004811Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.377Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5619Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase3.21e-12InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase3.462e-06InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.005397InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase5.502e-09Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase7.312e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processCell cycle1.856e-15Moderately InformativeDirect
Biological processDifferentiation4.281e-08Moderately InformativeDirect
Biological processApoptosis3.704e-05Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processNeurogenesis9.402e-08InformativeDirect
Biological processInnate immunity8.54e-07InformativeDirect
Biological processmRNA splicing9.568e-05InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Biological processChromosome partition6.596e-09Highly InformativeDirect
Biological processNonsense-mediated mRNA decay1.327e-07Highly InformativeDirect
Biological processAntiviral defense6.558e-07Highly InformativeDirect
Biological processUnfolded protein response2.878e-06Highly InformativeDirect
Biological processRNA-mediated gene silencing1.089e-05Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentMitochondrion1.583e-15Moderately InformativeDirect
Cellular componentEndoplasmic reticulum8.503e-06Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0008184Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSpliceosome0InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeroxisome1.465e-12InformativeDirect
Cellular componentCell outer membrane2.982e-06InformativeDirect
Cellular componentChromosome0.1435InformativeInherited
Cellular componentCilium0Highly InformativeDirect
Cellular componentProteasome3.161e-05Highly InformativeDirect
Cellular componentTelomere0.0001688Highly InformativeDirect
DiseaseCiliopathy1.025e-06InformativeDirect
DiseaseMental retardation0.0005234Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTPR repeat0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationActivator6.693e-08Moderately InformativeDirect
Post-translational modificationIsomerase0.5593Moderately InformativeInherited
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationProtein phosphatase3.925e-07InformativeDirect
Post-translational modificationChaperone3.132e-06InformativeDirect
Post-translational modificationChromatin regulator3.197e-06InformativeDirect
Post-translational modificationInitiation factor6.2e-06InformativeDirect
Post-translational modificationRotamase0Highly InformativeDirect
Post-translational modificationDioxygenase1.772e-14Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation3.297e-05Moderately InformativeDirect
Post-translational modificationPalmitate0.0004052Moderately InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)glycan metabolism1.023e-06Moderately InformativeDirect
UniPathway (UP)cellulose metabolism2.146e-16InformativeDirect
UniPathway (UP)bacterial cellulose biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]