SUPERFAMILY 1.75 HMM library and genome assignments server


Sec7 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Sec7 domain [ 48425]
Families:   Sec7 domain [ 48426] (5)


Superfamily statistics
Genomes (466) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 3,307 2,827 10
Proteins 3,290 2,817 10


Functional annotation
General category Regulation
Detailed category Other regulatory function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1.947e-05 Least Informative Direct
Biological Process (BP) localization 0.000188 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.8237 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.7255 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.001131 Least Informative Inherited
Biological Process (BP) response to stimulus 0.6461 Least Informative Inherited
Biological Process (BP) organelle organization 0.0002669 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.02144 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.001234 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.03561 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.2498 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.6601 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.07704 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1549 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1441 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.9068 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.2895 Moderately Informative Inherited
Biological Process (BP) tissue development 0.008905 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.05601 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.05398 Moderately Informative Inherited
Biological Process (BP) regulation of anatomical structure size 9.143e-06 Informative Direct
Biological Process (BP) vesicle-mediated transport 2.838e-05 Informative Direct
Biological Process (BP) cellular membrane organization 3.564e-05 Informative Direct
Biological Process (BP) actin filament-based process 5.345e-05 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 6.895e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0001465 Informative Direct
Biological Process (BP) muscle structure development 0.0003904 Informative Direct
Biological Process (BP) muscle tissue development 0.0005681 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0006084 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.004881 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.00492 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.1375 Informative Inherited
Biological Process (BP) organ morphogenesis 0.003155 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 7.589e-12 Highly Informative Direct
Biological Process (BP) multi-organism behavior 1.531e-08 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 5.012e-08 Highly Informative Direct
Biological Process (BP) regulation of Ras protein signal transduction 7.169e-08 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 6.48e-07 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 1.858e-06 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 2.516e-06 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 5.634e-06 Highly Informative Direct
Biological Process (BP) muscle organ development 2.319e-05 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 3.39e-05 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 9.247e-05 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.001285 Highly Informative Inherited
Biological Process (BP) regulation of cellular component size 0.00215 Highly Informative Inherited
Molecular Function (MF) binding 0.008404 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) protein binding 9.045e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0003007 Moderately Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 2.087e-07 Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 4.413e-13 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.06292 Highly Informative Inherited
Cellular Component (CC) membrane 1.871e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.704 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.7025 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.3642 Least Informative Inherited
Cellular Component (CC) cell projection 0.0001175 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0002404 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.05927 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 3.76e-14 Informative Direct
Cellular Component (CC) cell junction 4.509e-09 Informative Direct
Cellular Component (CC) cell leading edge 1.415e-06 Informative Direct
Cellular Component (CC) endosome 0.0005736 Informative Direct
Cellular Component (CC) neuron part 0.1185 Informative Inherited
Cellular Component (CC) trans-Golgi network 3.733e-11 Highly Informative Direct
Cellular Component (CC) ruffle 5.002e-07 Highly Informative Direct
Cellular Component (CC) organelle subcompartment 1.024e-06 Highly Informative Direct
Cellular Component (CC) Golgi membrane 5.262e-05 Highly Informative Direct
Cellular Component (CC) adherens junction 0.0001182 Highly Informative Direct
Cellular Component (CC) dendrite 0.0004674 Highly Informative Direct
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0Least InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.002495Moderately InformativeInherited
Plant structure DEvelopment stage (PDE)L mature pollen stage0.0005778InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport3.35e-06Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentGolgi apparatus2.644e-11Moderately InformativeDirect
Cellular componentCell projection1.048e-08Moderately InformativeDirect
Cellular componentEndosome3.495e-06Moderately InformativeDirect
Cellular componentCell junction1.601e-05Moderately InformativeDirect
Cellular componentSynapse1.582e-07InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationPhosphoprotein3.96e-14Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000904 SSF48425 Protein matches
Abstract The SEC7 domain was named after the first protein found to contain such a region [PubMed3042778]. It has been shown to be linked with guanine nucleotide exchange function [PubMed9072969, PubMed9442017]. The 3D structure of the domain displays several alpha-helices [PubMed9653114]. It was found to be associated with other domains involved in guanine nucleotide exchange (e.g., CDC25, Dbl) in mammalian factors [PubMed9868368].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Sec7 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Sec7 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]