SUPERFAMILY 1.75 HMM library and genome assignments server

Please note: Superfamily is currently under maintenance and some functionality may be limited. Please bear with us as we fix these problems.


Sec7 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Sec7 domain [ 48425]
Families:   Sec7 domain [ 48426] (5)


Superfamily statistics
Genomes (525) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,649 3,953 10
Proteins 3,631 3,937 10


Functional annotation
General category Regulation
Detailed category Other regulatory function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.000000007273 Least Informative Direct
Biological Process (BP) localization 0.00003441 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00007645 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00008746 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.1933 Least Informative Inherited
Biological Process (BP) developmental process 0.3382 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.6927 Least Informative Inherited
Biological Process (BP) response to stimulus 0.6126 Least Informative Inherited
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00009839 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0001267 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0003747 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.000902 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.02459 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.1477 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6406 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4349 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.09709 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01265 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.05041 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.00729 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000000005131 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000001083 Informative Direct
Biological Process (BP) actin filament-based process 0.00001372 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.00006758 Informative Direct
Biological Process (BP) organ morphogenesis 0.0001226 Informative Direct
Biological Process (BP) cellular membrane organization 0.0001294 Informative Direct
Biological Process (BP) muscle tissue development 0.0004298 Informative Direct
Biological Process (BP) muscle structure development 0.0004365 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.06502 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.01853 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.09937 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.00000000001406 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0000000002761 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.00000001542 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.00000004008 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.00003695 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0000621 Highly Informative Direct
Biological Process (BP) muscle organ development 0.00007271 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0006769 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.2687 Highly Informative Inherited
Molecular Function (MF) binding 0.000009786 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0000000005012 Moderately Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.00000002256 Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.00000002008 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00000004357 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.3039 Highly Informative Inherited
Cellular Component (CC) membrane 0.00000004708 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.9861 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3335 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.06241 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.00003329 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0002861 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.04656 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) cell junction 0.00000006751 Informative Direct
Cellular Component (CC) cell leading edge 0.000001389 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) trans-Golgi network 0.0000000000009076 Highly Informative Direct
Cellular Component (CC) adherens junction 0.0001881 Highly Informative Direct
Cellular Component (CC) dendrite 0.0002899 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.002141Moderately InformativeInherited
Plant structure DEvelopment stage (PDE)L mature pollen stage0.0004945InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000003539Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0.0001235Least InformativeDirect
Cellular componentGolgi apparatus0.00000000004067Moderately InformativeDirect
Cellular componentCell projection0.00000002858Moderately InformativeDirect
Cellular componentEndosome0.000006727Moderately InformativeDirect
Cellular componentCell junction0.00002491Moderately InformativeDirect
Cellular componentSynapse0.0000002339InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationPhosphoprotein0.0000000001294Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000904 SSF48425 Protein matches
Abstract The SEC7 domain was named after the first protein found to contain such a region [PubMed3042778]. It has been shown to be linked with guanine nucleotide exchange function [PubMed9072969, PubMed9442017]. The 3D structure of the domain displays several alpha-helices [PubMed9653114]. It was found to be associated with other domains involved in guanine nucleotide exchange (e.g., CDC25, Dbl) in mammalian factors [PubMed9868368].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Sec7 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Sec7 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]