SUPERFAMILY 1.75 HMM library and genome assignments server


Ankyrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Families:   Ankyrin repeat [ 48404] (17)


Superfamily statistics
Genomes (1,780) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 77,215 110,305 42
Proteins 66,626 94,099 42


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization10.296Least InformativeInherited
Biological Process (BP)single-organism cellular process0.7610.05032Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.74180.1842Least InformativeInherited
Biological Process (BP)developmental process0.0060660.0009861Least InformativeInherited
Biological Process (BP)regulation of cellular process0.021571Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0087431.539e-07Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.00099730.7188Least InformativeInherited
Biological Process (BP)negative regulation of cellular process4.472e-057.09e-05Moderately InformativeDirect
Biological Process (BP)regulation of localization0.63520.004862Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.012930.7831Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.04575Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.15920.7412Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.60230.8643Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.067571Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function11Moderately InformativeInherited
Biological Process (BP)immune system process0.11950.9664Moderately InformativeInherited
Biological Process (BP)organ development0.67890.8645Moderately InformativeInherited
Biological Process (BP)cellular localization0.34580.02244Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.31730.001434Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.00041Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.009441Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.038250.1429Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.25770.1253Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.8781Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0045230.6589Moderately InformativeInherited
Biological Process (BP)cell cycle process6.394e-062.556e-08InformativeDirect
Biological Process (BP)regulation of establishment of protein localization0.39230.01204InformativeInherited
Biological Process (BP)regulation of intracellular transport0.013130.1245InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.00051640.003998InformativeInherited
Biological Process (BP)negative regulation of catalytic activity0.00087430.04758InformativeInherited
Biological Process (BP)negative regulation of transport0.22070.1242InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.00021290.1009InformativeInherited
Biological Process (BP)mitotic cell cycle0.13561InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.50551InformativeInherited
Biological Process (BP)regulation of cytokine production0.052170.1163InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.13090.02898InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.50530.5423InformativeInherited
Biological Process (BP)regulation of protein phosphorylation9.179e-081InformativeInherited
Biological Process (BP)regulation of kinase activity4.992e-100.8849InformativeInherited
Biological Process (BP)negative regulation of intracellular transport0.00017185.541e-07Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation6.231e-050.0005571Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition1.534e-102.649e-05Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport8.179e-050.0001385Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport0.00085391.069e-06Highly InformativeDirect
Biological Process (BP)maintenance of location1.456e-052.738e-09Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus0.00069978.623e-05Highly InformativeDirect
Biological Process (BP)regulation of intracellular protein transport0.013310.001606Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process1.134e-050.1114Highly InformativeInherited
Biological Process (BP)cell cycle phase0.027640.02771Highly InformativeInherited
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.00021660.06443Highly InformativeInherited
Biological Process (BP)regulation of cytokine biosynthetic process0.020760.006413Highly InformativeInherited
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity0.036580.01741Highly InformativeInherited
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway2.707e-070.1608Highly InformativeInherited
Biological Process (BP)regulation of cellular response to growth factor stimulus1.387e-060.6847Highly InformativeInherited
Biological Process (BP)negative regulation of cell cycle9.136e-070.002704Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.001260.002903Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity0.00016554.87e-05InformativeDirect
Molecular Function (MF)enzyme binding1.45e-102.056e-08InformativeDirect
Molecular Function (MF)protein kinase regulator activity05.49e-09Highly InformativeDirect
Molecular Function (MF)transcription factor binding2.98e-050.07503Highly InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.51136.768e-08Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)extracellular region part11Moderately InformativeInherited
Cellular Component (CC)cell projection0.23023.835e-07Moderately InformativeInherited
Cellular Component (CC)cell-cell junction0.37761InformativeInherited
Cellular Component (CC)neuron projection0.0044114.281e-05InformativeInherited
Cellular Component (CC)contractile fiber part0.0016046.169e-15InformativeInherited
Cellular Component (CC)cell-cell contact zone1.225e-054.023e-05Highly InformativeDirect
Cellular Component (CC)main axon6.864e-060.5191Highly InformativeInherited
Cellular Component (CC)sarcomere0.00053880.007247Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1.539e-07 Least Informative Direct
Biological Process (BP) developmental process 0.0009861 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.1842 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.7188 Least Informative Inherited
Biological Process (BP) localization 0.296 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.05032 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) ion transport 2.761e-10 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0005877 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 5.42e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 7.09e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 0.03508 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.004862 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.6538 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7412 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.04575 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4808 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6589 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1429 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7831 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.01217 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9664 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1993 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2812 Moderately Informative Inherited
Biological Process (BP) system process 0.001212 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1573 Moderately Informative Inherited
Biological Process (BP) reproduction 0.04201 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.02244 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.001434 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.1253 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.7708 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8643 Moderately Informative Inherited
Biological Process (BP) organ development 0.8645 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 6.3e-06 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0005498 Informative Direct
Biological Process (BP) protein transport 0.0001903 Informative Direct
Biological Process (BP) sexual reproduction 2.134e-06 Informative Direct
Biological Process (BP) cell cycle process 2.556e-08 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0001094 Informative Direct
Biological Process (BP) cell projection organization 1.243e-13 Informative Direct
Biological Process (BP) cellular component morphogenesis 4.463e-14 Informative Direct
Biological Process (BP) growth 0.0002087 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.406e-05 Informative Direct
Biological Process (BP) single organism reproductive process 2.145e-09 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 5.716e-05 Informative Direct
Biological Process (BP) cellular process involved in reproduction 7.144e-06 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0002338 Informative Direct
Biological Process (BP) regulation of nervous system development 1.418e-06 Informative Direct
Biological Process (BP) transmembrane transport 0.0009411 Informative Direct
Biological Process (BP) muscle tissue development 8.697e-06 Informative Direct
Biological Process (BP) muscle structure development 4.212e-08 Informative Direct
Biological Process (BP) generation of neurons 0.1271 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.3671 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.835 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.01204 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1245 Informative Inherited
Biological Process (BP) cellular membrane organization 0.02965 Informative Inherited
Biological Process (BP) secretion by cell 0.1789 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.827 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.003998 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.04758 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1261 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.9694 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.4474 Informative Inherited
Biological Process (BP) response to lipid 0.4838 Informative Inherited
Biological Process (BP) response to other organism 0.2131 Informative Inherited
Biological Process (BP) metal ion transport 0.03424 Informative Inherited
Biological Process (BP) cardiovascular system development 0.6795 Informative Inherited
Biological Process (BP) tube development 0.09446 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) blood circulation 0.006173 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.08992 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.724 Informative Inherited
Biological Process (BP) actin filament-based process 0.03945 Informative Inherited
Biological Process (BP) regulation of system process 0.1501 Informative Inherited
Biological Process (BP) synaptic transmission 0.6997 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.1009 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.01064 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) organelle assembly 0.7341 Informative Inherited
Biological Process (BP) DNA metabolic process 0.0492 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.1163 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.02898 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.252 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.03642 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.948 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.9288 Informative Inherited
Biological Process (BP) epithelium development 0.5659 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.001463 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.2006 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.7025 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.954 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.03079 Informative Inherited
Biological Process (BP) positive regulation of transport 0.273 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.5933 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.5541 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.5423 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.7464 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) regulation of growth 0.09516 Informative Inherited
Biological Process (BP) regulation of cell development 0.05994 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.5822 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.457 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.4293 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.002089 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) locomotion 0.4726 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1242 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.07081 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7085 Informative Inherited
Biological Process (BP) muscle system process 0.03657 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.2823 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.1731 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) immune response 0.2106 Informative Inherited
Biological Process (BP) defense response 0.928 Informative Inherited
Biological Process (BP) response to wounding 0.8859 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.8849 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) DNA modification 0 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 0.0002608 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0009734 Highly Informative Direct
Biological Process (BP) striated muscle contraction 0.0002333 Highly Informative Direct
Biological Process (BP) meiosis 1.285e-11 Highly Informative Direct
Biological Process (BP) spermatogenesis 1.654e-09 Highly Informative Direct
Biological Process (BP) muscle organ development 2.047e-07 Highly Informative Direct
Biological Process (BP) sensory perception 8.7e-08 Highly Informative Direct
Biological Process (BP) response to heat 0.0003189 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 6.393e-05 Highly Informative Direct
Biological Process (BP) cell growth 6.104e-11 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 5.929e-06 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 3.385e-05 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 5.541e-07 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 1.135e-11 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 8.755e-05 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 2.909e-12 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 1.062e-09 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 1.721e-06 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0005571 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 1.178e-06 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 2.649e-05 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0001574 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0001385 Highly Informative Direct
Biological Process (BP) developmental growth 9.941e-06 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 3.645e-06 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 5.162e-06 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 1.432e-05 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 1.069e-06 Highly Informative Direct
Biological Process (BP) maintenance of location 2.738e-09 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0.0001076 Highly Informative Direct
Biological Process (BP) heart contraction 8.289e-11 Highly Informative Direct
Biological Process (BP) myeloid cell development 8.404e-05 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 8.623e-05 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.0007695 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.742 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.4179 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.001606 Highly Informative Inherited
Biological Process (BP) renal system development 0.04846 Highly Informative Inherited
Biological Process (BP) cell cycle phase 0.02771 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.6868 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.1114 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.05471 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.007197 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.002657 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.05466 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.212 Highly Informative Inherited
Biological Process (BP) protein methylation 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.3428 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.0108 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.5694 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.06443 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.01148 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.001844 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.2191 Highly Informative Inherited
Biological Process (BP) axon development 0.256 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02035 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.2914 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.2134 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.004202 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.127 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.006413 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.7007 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.5485 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.04486 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.8865 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.001492 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.4379 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.1205 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.9406 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.04645 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.002247 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.7813 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.01741 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.9695 Highly Informative Inherited
Biological Process (BP) DNA replication 1 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.02411 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.9735 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.06394 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.1608 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.6847 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.005123 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.7206 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.6738 Highly Informative Inherited
Biological Process (BP) learning or memory 0.01307 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.0011 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.993 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.9818 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.002704 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) glutamine family amino acid catabolic process 0.006229 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.7606 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.3452 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.1138 Highly Informative Inherited
Biological Process (BP) protein import 0.2089 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.5387 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.9875 Highly Informative Inherited
Biological Process (BP) nuclear import 0.2769 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0004969 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.08715 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.002903 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 4.87e-05 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 4.137e-06 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.0005326 Informative Direct
Molecular Function (MF) enzyme binding 2.056e-08 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 8.625e-11 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.01917 Informative Inherited
Molecular Function (MF) lipid binding 0.1506 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.9769 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.1012 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.3281 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.4581 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) cation channel activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) channel regulator activity 7.713e-07 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 2.791e-06 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 5.49e-09 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.0004187 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.07503 Highly Informative Inherited
Molecular Function (MF) glycolipid binding 0.001696 Highly Informative Inherited
Molecular Function (MF) methyltransferase activity 0.9382 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.0929 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.02995 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.2419 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.7014 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 0.1658 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.1224 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 6.768e-08 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cell projection 3.835e-07 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.9305 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.5889 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.0431 Moderately Informative Inherited
Cellular Component (CC) cell cortex 1.532e-05 Informative Direct
Cellular Component (CC) neuron projection 4.281e-05 Informative Direct
Cellular Component (CC) contractile fiber part 6.169e-15 Informative Direct
Cellular Component (CC) synapse part 9.654e-08 Informative Direct
Cellular Component (CC) endosome 0.07268 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.02115 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.05163 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) adherens junction 2.034e-10 Highly Informative Direct
Cellular Component (CC) cell-cell contact zone 4.023e-05 Highly Informative Direct
Cellular Component (CC) membrane raft 0.0002659 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 1.944e-05 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0.05337 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.01652 Highly Informative Inherited
Cellular Component (CC) main axon 0.5191 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.007247 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.7157 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.908 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.4016Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1213Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1.232e-09Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0008122Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001342Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3822Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase3.44e-13InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase2.201e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2916Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.01804Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system cancer0.1363Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.1727InformativeInherited
Disease Ontology (DO)skin hemangioma5.243e-06Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0006038Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.2106Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.05211InformativeInherited
Phenotypic Abnormality (PA)Melanoma0.0001103Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.2303Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4388Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.03534Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2323Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.04485InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.3311InformativeInherited
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0002193Highly InformativeDirect
Mammalian Phenotype (MP)incomplete somite formation0.0002956Highly InformativeDirect
Mammalian Phenotype (MP)scaly skin0.0006166Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01108Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.9899Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant3.662e-05InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0001255InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.01861Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

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YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.0547InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sensory perception defective9.096e-09InformativeDirect
Fly Phenotype (FP)neurophysiology defective1.892e-06InformativeDirect
Fly Phenotype (FP)gravitaxis defective0.0007624Highly InformativeDirect
Fly Phenotype (FP)temperature response defective0.006985Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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