SUPERFAMILY 1.75 HMM library and genome assignments server


Ankyrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Families:   Ankyrin repeat [ 48404] (17)


Superfamily statistics
Genomes (1,780) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 77,215 110,305 42
Proteins 66,626 94,099 42


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.49420.04083Least InformativeInherited
Biological Process (BP)localization10.3953Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.7980.2801Least InformativeInherited
Biological Process (BP)developmental process0.0081780.001321Least InformativeInherited
Biological Process (BP)regulation of cellular process0.021831Least InformativeInherited
Biological Process (BP)multicellular organismal process0.011627.336e-07Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.00098840.6852Least InformativeInherited
Biological Process (BP)negative regulation of cellular process5.087e-050.0005335Moderately InformativeDirect
Biological Process (BP)regulation of localization0.65340.0004549Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.015630.786Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.0553Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.14020.7743Moderately InformativeInherited
Biological Process (BP)multi-organism process0.91011Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.17681Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.81650.3192Moderately InformativeInherited
Biological Process (BP)response to organic substance0.88661Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.61050.7718Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.065360.9741Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function11Moderately InformativeInherited
Biological Process (BP)immune system process0.13111Moderately InformativeInherited
Biological Process (BP)organ development0.68690.9172Moderately InformativeInherited
Biological Process (BP)cellular localization0.37150.03099Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.33480.001467Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.75860.0654Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.00045981Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.024111Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.18231Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.041550.1693Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.24170.3222Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.87580.9037Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.005070.7936Moderately InformativeInherited
Biological Process (BP)cell cycle process7.357e-065.219e-08InformativeDirect
Biological Process (BP)regulation of mitotic cell cycle0.21040.4418InformativeInherited
Biological Process (BP)regulation of cell cycle process0.46691InformativeInherited
Biological Process (BP)regulation of protein localization0.045220.3642InformativeInherited
Biological Process (BP)regulation of intracellular transport0.013610.2874InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.00042850.00278InformativeInherited
Biological Process (BP)negative regulation of catalytic activity0.00097460.05563InformativeInherited
Biological Process (BP)response to bacterium0.020180.0004057InformativeInherited
Biological Process (BP)response to lipid0.081510.1946InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.18690.03974InformativeInherited
Biological Process (BP)negative regulation of transport0.21680.169InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.00022110.0923InformativeInherited
Biological Process (BP)mitotic cell cycle0.14261InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.50651InformativeInherited
Biological Process (BP)regulation of cytokine production0.047840.1252InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.12290.04379InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.50430.6938InformativeInherited
Biological Process (BP)regulation of protein phosphorylation1.62e-071InformativeInherited
Biological Process (BP)regulation of kinase activity6.454e-100.8293InformativeInherited
Biological Process (BP)negative regulation of intracellular transport0.00016574.996e-07Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation5.602e-050.0004434Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition1.532e-102.337e-05Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport9.208e-050.0001011Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport0.00094169.917e-07Highly InformativeDirect
Biological Process (BP)maintenance of location1.681e-053.728e-09Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus7.732e-051.18e-05Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus0.00057910.0001159Highly InformativeDirect
Biological Process (BP)negative regulation of mitotic cell cycle phase transition3.792e-080.000172Highly InformativeDirect
Biological Process (BP)regulation of intracellular protein transport0.01350.001414Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process9.661e-060.1084Highly InformativeInherited
Biological Process (BP)response to lipopolysaccharide0.0010259.689e-05Highly InformativeInherited
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.0002560.07274Highly InformativeInherited
Biological Process (BP)regulation of cytokine biosynthetic process0.019760.006102Highly InformativeInherited
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity0.036370.01671Highly InformativeInherited
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway2.357e-070.1537Highly InformativeInherited
Biological Process (BP)regulation of cellular response to growth factor stimulus1.261e-060.7126Highly InformativeInherited
Biological Process (BP)negative regulation of cell cycle7.111e-070.002523Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.0013220.002601Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity0.0001626.939e-05InformativeDirect
Molecular Function (MF)enzyme binding2.015e-103.854e-09InformativeDirect
Molecular Function (MF)protein kinase regulator activity07.387e-09Highly InformativeDirect
Molecular Function (MF)transcription factor binding3.601e-050.07374Highly InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.65296.51e-07Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)extracellular region part11Moderately InformativeInherited
Cellular Component (CC)cell projection0.26631.937e-06Moderately InformativeInherited
Cellular Component (CC)cell junction0.051988.756e-11InformativeInherited
Cellular Component (CC)neuron projection0.0063575.613e-05InformativeInherited
Cellular Component (CC)contractile fiber part0.0016981.045e-14InformativeInherited
Cellular Component (CC)cell-cell contact zone1.284e-054.53e-05Highly InformativeDirect
Cellular Component (CC)main axon7.175e-060.391Highly InformativeInherited
Cellular Component (CC)sarcomere0.000570.007238Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 7.336e-07 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.2801 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.6852 Least Informative Inherited
Biological Process (BP) localization 0.3953 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.04083 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.001321 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) ion transport 4.875e-10 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 9.847e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0004549 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0005335 Moderately Informative Direct
Biological Process (BP) nervous system development 0.02663 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.9037 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.648 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7743 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.0553 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3192 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.7936 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.001395 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1693 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.786 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9741 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1736 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4011 Moderately Informative Inherited
Biological Process (BP) system process 0.001371 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2213 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0577 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.03099 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.001467 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.3222 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.0654 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.8319 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.7718 Moderately Informative Inherited
Biological Process (BP) organ development 0.9172 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9756 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 9.493e-06 Informative Direct
Biological Process (BP) response to bacterium 0.0004057 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000771 Informative Direct
Biological Process (BP) protein transport 0.0003003 Informative Direct
Biological Process (BP) sexual reproduction 2.333e-06 Informative Direct
Biological Process (BP) cell cycle process 5.219e-08 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000163 Informative Direct
Biological Process (BP) cell projection organization 3.613e-13 Informative Direct
Biological Process (BP) cellular component morphogenesis 6.398e-14 Informative Direct
Biological Process (BP) growth 0.0005108 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 9.949e-06 Informative Direct
Biological Process (BP) single organism reproductive process 5.043e-09 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 5.663e-05 Informative Direct
Biological Process (BP) cellular process involved in reproduction 1.115e-05 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0003344 Informative Direct
Biological Process (BP) regulation of nervous system development 1.154e-06 Informative Direct
Biological Process (BP) muscle tissue development 4.95e-06 Informative Direct
Biological Process (BP) muscle structure development 3.416e-08 Informative Direct
Biological Process (BP) generation of neurons 0.132 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.4418 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.3642 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.2874 Informative Inherited
Biological Process (BP) cellular membrane organization 0.02458 Informative Inherited
Biological Process (BP) secretion by cell 0.2137 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.8347 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.9704 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.00278 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.05563 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.03974 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.9994 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.5002 Informative Inherited
Biological Process (BP) metal ion transport 0.03757 Informative Inherited
Biological Process (BP) cardiovascular system development 0.6464 Informative Inherited
Biological Process (BP) tube development 0.08234 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) blood circulation 0.007225 Informative Inherited
Biological Process (BP) cation homeostasis 0.01275 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.113 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.04995 Informative Inherited
Biological Process (BP) regulation of system process 0.1074 Informative Inherited
Biological Process (BP) synaptic transmission 0.7144 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.0923 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.0105 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) organelle assembly 0.7809 Informative Inherited
Biological Process (BP) DNA metabolic process 0.06321 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.1252 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.04379 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2353 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.04592 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.95 Informative Inherited
Biological Process (BP) epithelium development 0.4427 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.001862 Informative Inherited
Biological Process (BP) transmembrane transport 0.001276 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.1892 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.8948 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.5605 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.8901 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.9997 Informative Inherited
Biological Process (BP) response to lipid 0.1946 Informative Inherited
Biological Process (BP) regulation of ion transport 0.1165 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.6306 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.6522 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.6938 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.8474 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.03661 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) regulation of growth 0.1238 Informative Inherited
Biological Process (BP) regulation of cell development 0.06655 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.5366 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.41 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.4181 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.001848 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) locomotion 0.5197 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.169 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1054 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7608 Informative Inherited
Biological Process (BP) muscle system process 0.03807 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) immune response 0.2356 Informative Inherited
Biological Process (BP) defense response 0.9754 Informative Inherited
Biological Process (BP) response to wounding 0.9225 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.8293 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.000298 Highly Informative Direct
Biological Process (BP) DNA modification 0 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 0.0002742 Highly Informative Direct
Biological Process (BP) striated muscle contraction 0.0003099 Highly Informative Direct
Biological Process (BP) meiosis 1.437e-11 Highly Informative Direct
Biological Process (BP) spermatogenesis 3.616e-09 Highly Informative Direct
Biological Process (BP) muscle organ development 2.653e-07 Highly Informative Direct
Biological Process (BP) sensory perception 6.873e-08 Highly Informative Direct
Biological Process (BP) response to heat 0.0004054 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 1.227e-05 Highly Informative Direct
Biological Process (BP) cell growth 1.281e-10 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 1.606e-05 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 2.763e-05 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0009885 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 4.996e-07 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 3.358e-11 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 9.689e-05 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 5.378e-12 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 2.744e-09 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 2e-06 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0004434 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 2.96e-06 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 2.337e-05 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0002947 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0001011 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0009204 Highly Informative Direct
Biological Process (BP) developmental growth 6.143e-06 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 4.85e-06 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 9.917e-07 Highly Informative Direct
Biological Process (BP) maintenance of location 3.728e-09 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0.0001294 Highly Informative Direct
Biological Process (BP) heart contraction 1.369e-10 Highly Informative Direct
Biological Process (BP) myeloid cell development 9.405e-05 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 1.18e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.0002998 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0001159 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.000172 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0.9902 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.814 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.4927 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.001414 Highly Informative Inherited
Biological Process (BP) renal system development 0.04309 Highly Informative Inherited
Biological Process (BP) cell cycle phase 0.02474 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.6943 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.1084 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.05881 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.05064 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.2279 Highly Informative Inherited
Biological Process (BP) protein methylation 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.3701 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.01067 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.07274 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.01358 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.001919 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.2293 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.0206 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.01835 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.3309 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.2061 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.003511 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.1247 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.006102 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.7208 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.6437 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.05214 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.001381 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.4562 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.1294 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.8756 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.4639 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.04921 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.001839 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.8106 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.01671 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.9969 Highly Informative Inherited
Biological Process (BP) DNA replication 1 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.02202 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 1 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.06631 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.1537 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.7126 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.005555 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.7032 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.6557 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle cell differentiation 0.4444 Highly Informative Inherited
Biological Process (BP) learning or memory 0.01218 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.996 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.002523 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) glutamine family amino acid catabolic process 0.00658 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.7728 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.3742 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.1075 Highly Informative Inherited
Biological Process (BP) protein import 0.2198 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.5503 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.9905 Highly Informative Inherited
Biological Process (BP) nuclear import 0.2854 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0005835 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.09477 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.002601 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 6.939e-05 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 3.917e-06 Informative Direct
Molecular Function (MF) enzyme binding 3.854e-09 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 9.668e-11 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.01989 Informative Inherited
Molecular Function (MF) lipid binding 0.1218 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 1 Informative Inherited
Molecular Function (MF) ligase activity 0.1003 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.1295 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.2647 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.4835 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) cation channel activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) channel regulator activity 7.614e-07 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 2.009e-06 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 7.387e-09 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.0004915 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.07374 Highly Informative Inherited
Molecular Function (MF) glycolipid binding 0.002156 Highly Informative Inherited
Molecular Function (MF) methyltransferase activity 0.9715 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.09505 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.03369 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.2409 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.8546 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 0.105 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.1375 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 6.51e-07 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cell projection 1.937e-06 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.9685 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.6293 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.04125 Moderately Informative Inherited
Cellular Component (CC) cell cortex 2.223e-05 Informative Direct
Cellular Component (CC) cell junction 8.756e-11 Informative Direct
Cellular Component (CC) neuron projection 5.613e-05 Informative Direct
Cellular Component (CC) contractile fiber part 1.045e-14 Informative Direct
Cellular Component (CC) synapse part 5.485e-07 Informative Direct
Cellular Component (CC) endosome 0.09133 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.02506 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.09758 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) adherens junction 2.675e-10 Highly Informative Direct
Cellular Component (CC) cell-cell contact zone 4.53e-05 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 3.764e-05 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0.05794 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.01754 Highly Informative Inherited
Cellular Component (CC) main axon 0.391 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.007238 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.9361 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.4016Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1213Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1.232e-09Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0008122Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001342Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3822Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase3.44e-13InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase2.201e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)benign neoplasm0.01858Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.1766InformativeInherited
Disease Ontology (DO)skin hemangioma4.99e-06Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.2036Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.0511InformativeInherited
Phenotypic Abnormality (PA)Melanoma0.0001142Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.3089Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5447Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.04524Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.3096Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.04076InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.2595InformativeInherited
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0001618Highly InformativeDirect
Mammalian Phenotype (MP)incomplete somite formation0.0002624Highly InformativeDirect
Mammalian Phenotype (MP)scaly skin0.0005642Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01108Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.9899Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant3.662e-05InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0001255InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.01861Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

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YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.05443InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sensory perception defective1.025e-08InformativeDirect
Fly Phenotype (FP)neurophysiology defective1.928e-06InformativeDirect
Fly Phenotype (FP)temperature response defective0.0001638Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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