SUPERFAMILY 1.75 HMM library and genome assignments server


Ankyrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Families:   Ankyrin repeat [ 48404] (17)


Superfamily statistics
Genomes (1,772) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 74,739 110,305 42
Proteins 64,416 94,099 42


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization10.2252Least InformativeInherited
Biological Process (BP)single-organism cellular process0.71550.02389Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.70820.3818Least InformativeInherited
Biological Process (BP)developmental process0.0053130.0002706Least InformativeInherited
Biological Process (BP)regulation of cellular process0.024651Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0077252.551e-08Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.00079720.573Least InformativeInherited
Biological Process (BP)single-organism developmental process0.00011681.544e-11Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process2.759e-053.145e-05Moderately InformativeDirect
Biological Process (BP)regulation of localization0.66950.001786Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.017860.7297Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.02321Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.00021021Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.1310.6958Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.69490.9099Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.10591Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function11Moderately InformativeInherited
Biological Process (BP)immune system process0.11780.9037Moderately InformativeInherited
Biological Process (BP)organ development0.67310.8824Moderately InformativeInherited
Biological Process (BP)cellular localization0.32950.01744Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.30440.001026Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.015911Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.26030.1012Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.87941Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0027720.6047Moderately InformativeInherited
Biological Process (BP)cell cycle process4.932e-062.173e-08InformativeDirect
Biological Process (BP)regulation of establishment of protein localization0.38790.01013InformativeInherited
Biological Process (BP)regulation of intracellular transport0.013050.1291InformativeInherited
Biological Process (BP)negative regulation of catalytic activity0.00043440.03369InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.00024790.002069InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.00021470.09432InformativeInherited
Biological Process (BP)mitotic cell cycle0.1281InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.48451InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.48710.4883InformativeInherited
Biological Process (BP)regulation of protein phosphorylation1.409e-081InformativeInherited
Biological Process (BP)regulation of kinase activity5.305e-110.8552InformativeInherited
Biological Process (BP)negative regulation of intracellular transport0.00016355.719e-07Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation2.199e-050.0002407Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition1.384e-102.637e-05Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport7.332e-050.0001796Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport0.0007841.173e-06Highly InformativeDirect
Biological Process (BP)maintenance of location1.383e-051.001e-09Highly InformativeDirect
Biological Process (BP)interphase0.00016265.333e-05Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus0.00074769.987e-05Highly InformativeDirect
Biological Process (BP)regulation of intracellular protein transport0.013550.001896Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process4.082e-060.07349Highly InformativeInherited
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.00021210.06517Highly InformativeInherited
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity0.042690.02037Highly InformativeInherited
Biological Process (BP)regulation of cellular response to growth factor stimulus1.444e-060.6584Highly InformativeInherited
Biological Process (BP)negative regulation of cell cycle1.182e-060.002379Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.001010.001802Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity0.00016254.917e-05InformativeDirect
Molecular Function (MF)enzyme binding9.496e-117.334e-09InformativeDirect
Molecular Function (MF)protein kinase regulator activity04.219e-09Highly InformativeDirect
Molecular Function (MF)transcription factor binding3.098e-050.07238Highly InformativeInherited
Cellular Component (CC)extracellular region part11Moderately InformativeInherited
Cellular Component (CC)cell projection0.21592.151e-07Moderately InformativeInherited
Cellular Component (CC)cell-cell junction0.53811InformativeInherited
Cellular Component (CC)neuron projection0.0040235.855e-05InformativeInherited
Cellular Component (CC)cell-cell contact zone1.166e-054.414e-05Highly InformativeDirect
Cellular Component (CC)main axon6.561e-060.5218Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 2.551e-08 Least Informative Direct
Biological Process (BP) developmental process 0.0002706 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.3818 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.573 Least Informative Inherited
Biological Process (BP) localization 0.2252 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.02389 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) ion transport 2.02e-10 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0003693 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 3.811e-05 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.544e-11 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 3.145e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0317 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.001786 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.7059 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.6958 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.02321 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3881 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6047 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1301 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7297 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.0155 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9037 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.15 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2465 Moderately Informative Inherited
Biological Process (BP) system process 0.00136 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1652 Moderately Informative Inherited
Biological Process (BP) reproduction 0.02481 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01744 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.001026 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.1012 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9099 Moderately Informative Inherited
Biological Process (BP) organ development 0.8824 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0.0007078 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0003779 Informative Direct
Biological Process (BP) protein transport 0.0001256 Informative Direct
Biological Process (BP) sexual reproduction 2.11e-06 Informative Direct
Biological Process (BP) cell cycle process 2.173e-08 Informative Direct
Biological Process (BP) negative regulation of signaling 7.625e-05 Informative Direct
Biological Process (BP) cell projection organization 5.37e-14 Informative Direct
Biological Process (BP) cellular component morphogenesis 8.997e-11 Informative Direct
Biological Process (BP) ncRNA metabolic process 0.0008357 Informative Direct
Biological Process (BP) growth 2.144e-06 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 8.495e-06 Informative Direct
Biological Process (BP) single organism reproductive process 1.239e-09 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 6.09e-05 Informative Direct
Biological Process (BP) cellular process involved in reproduction 3.628e-06 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0001398 Informative Direct
Biological Process (BP) regulation of nervous system development 1.214e-06 Informative Direct
Biological Process (BP) muscle tissue development 6.396e-06 Informative Direct
Biological Process (BP) muscle structure development 2.881e-08 Informative Direct
Biological Process (BP) generation of neurons 0.1359 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.3437 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.8379 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.01013 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1291 Informative Inherited
Biological Process (BP) cellular membrane organization 0.02418 Informative Inherited
Biological Process (BP) secretion by cell 0.1687 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.7987 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.002069 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.03369 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.09674 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.9858 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.3665 Informative Inherited
Biological Process (BP) response to lipid 0.4087 Informative Inherited
Biological Process (BP) response to other organism 0.1861 Informative Inherited
Biological Process (BP) metal ion transport 0.03554 Informative Inherited
Biological Process (BP) cardiovascular system development 0.685 Informative Inherited
Biological Process (BP) tube development 0.09645 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) blood circulation 0.004955 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.1461 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1084 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.6964 Informative Inherited
Biological Process (BP) actin filament-based process 0.6268 Informative Inherited
Biological Process (BP) regulation of system process 0.1311 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.005124 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.09432 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.01243 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) DNA metabolic process 0.04009 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.1014 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.03212 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.1998 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.04096 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.9233 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.8922 Informative Inherited
Biological Process (BP) epithelium development 0.5604 Informative Inherited
Biological Process (BP) regulation of ion transport 0.01965 Informative Inherited
Biological Process (BP) transmembrane transport 0.001301 Informative Inherited
Biological Process (BP) regulation of response to stress 0.3763 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.6754 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.9152 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.235 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.605 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.4923 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.4883 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.7424 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.1162 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) cell-cell signaling 0.07635 Informative Inherited
Biological Process (BP) regulation of growth 0.1018 Informative Inherited
Biological Process (BP) regulation of cell development 0.04732 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.5849 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.4277 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.4274 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.002884 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) locomotion 0.4061 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.06045 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6651 Informative Inherited
Biological Process (BP) muscle system process 0.05836 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.2433 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) immune response 0.1614 Informative Inherited
Biological Process (BP) defense response 0.9564 Informative Inherited
Biological Process (BP) response to wounding 0.9765 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.8552 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) DNA modification 0 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 0.0002215 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0007377 Highly Informative Direct
Biological Process (BP) striated muscle contraction 8.169e-05 Highly Informative Direct
Biological Process (BP) plasma membrane organization 6.162e-09 Highly Informative Direct
Biological Process (BP) meiosis 1.264e-11 Highly Informative Direct
Biological Process (BP) spermatogenesis 8.242e-10 Highly Informative Direct
Biological Process (BP) muscle organ development 1.484e-07 Highly Informative Direct
Biological Process (BP) sensory perception 1.799e-07 Highly Informative Direct
Biological Process (BP) response to heat 0.000558 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 3.885e-05 Highly Informative Direct
Biological Process (BP) cell growth 4.91e-11 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 4.219e-06 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 4.139e-05 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.0009567 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 5.719e-07 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 1.035e-11 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 0.0001125 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 3.313e-13 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 5.625e-10 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 1.21e-06 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0002407 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 7.635e-07 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 2.637e-05 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0001839 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0001796 Highly Informative Direct
Biological Process (BP) developmental growth 1.31e-05 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 3.527e-06 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.0002635 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 5.042e-06 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 9.398e-06 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 1.173e-06 Highly Informative Direct
Biological Process (BP) maintenance of location 1.001e-09 Highly Informative Direct
Biological Process (BP) interphase 5.333e-05 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0.0001077 Highly Informative Direct
Biological Process (BP) heart contraction 5.273e-11 Highly Informative Direct
Biological Process (BP) myeloid cell development 7.284e-05 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 9.987e-05 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.0007716 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.6859 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.3571 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.001896 Highly Informative Inherited
Biological Process (BP) renal system development 0.04826 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.6512 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.07349 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.04234 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.005248 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.001859 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.05591 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.2136 Highly Informative Inherited
Biological Process (BP) protein methylation 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.3015 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.01283 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.5481 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.06517 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.008356 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.001658 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.204 Highly Informative Inherited
Biological Process (BP) axon development 0.2739 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02536 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.2591 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.9803 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.2141 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.004296 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.00658 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.7228 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 0.894 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.5532 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.03697 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.8861 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.00158 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.3955 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.09432 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.9364 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.9098 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.002242 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.7482 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.02037 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.9516 Highly Informative Inherited
Biological Process (BP) DNA replication 1 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.02439 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.9703 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.06025 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.6584 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.005242 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.7067 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.6633 Highly Informative Inherited
Biological Process (BP) learning or memory 0.006125 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.001131 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.9774 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.9754 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.002379 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) glutamine family amino acid catabolic process 0.005524 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.7416 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.4498 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.09196 Highly Informative Inherited
Biological Process (BP) protein import 0.2061 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.5377 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.9861 Highly Informative Inherited
Biological Process (BP) nuclear import 0.2739 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0003795 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.9149 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.001802 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 4.917e-05 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 2.975e-06 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.0004116 Informative Direct
Molecular Function (MF) enzyme binding 7.334e-09 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 2.042e-11 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.009258 Informative Inherited
Molecular Function (MF) lipid binding 0.1439 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.9537 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.08284 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.2995 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.4277 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) cation channel activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) channel regulator activity 5.341e-07 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 2.036e-06 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 4.219e-09 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.0003663 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.07238 Highly Informative Inherited
Molecular Function (MF) glycolipid binding 0.001711 Highly Informative Inherited
Molecular Function (MF) methyltransferase activity 0.9205 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.08967 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.02528 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.2159 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.7008 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 0.1657 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.1121 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1.009e-06 Least Informative Direct
Cellular Component (CC) membrane 0.8162 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cell projection 2.151e-07 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.8653 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.534 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.8624 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.03186 Moderately Informative Inherited
Cellular Component (CC) cell cortex 1.034e-05 Informative Direct
Cellular Component (CC) neuron projection 5.855e-05 Informative Direct
Cellular Component (CC) contractile fiber part 3.599e-09 Informative Direct
Cellular Component (CC) synapse part 5.789e-08 Informative Direct
Cellular Component (CC) endosome 0.05808 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.01672 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.04762 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) Golgi membrane 4.54e-07 Highly Informative Direct
Cellular Component (CC) actin filament 4.661e-06 Highly Informative Direct
Cellular Component (CC) adherens junction 5.324e-12 Highly Informative Direct
Cellular Component (CC) neuromuscular junction 0.0002312 Highly Informative Direct
Cellular Component (CC) cell-cell contact zone 4.414e-05 Highly Informative Direct
Cellular Component (CC) membrane raft 0.0002048 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 2.829e-05 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0.04789 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.01333 Highly Informative Inherited
Cellular Component (CC) recycling endosome 0.2296 Highly Informative Inherited
Cellular Component (CC) main axon 0.5218 Highly Informative Inherited
Cellular Component (CC) transcription elongation factor complex 0.009365 Highly Informative Inherited
Cellular Component (CC) trans-Golgi network 0.2751 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.0341 Highly Informative Inherited
Cellular Component (CC) transcription factor complex 1 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.3322 Highly Informative Inherited
Cellular Component (CC) replisome 0.003809 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.8793 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.4016Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1213Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1.232e-09Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0008122Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001342Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3822Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase3.44e-13InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase2.201e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)benign neoplasm0.03241Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.2464InformativeInherited
Disease Ontology (DO)skin hemangioma5.131e-06Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.2565Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4635Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.04075Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2344Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.0467InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.3312InformativeInherited
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0002315Highly InformativeDirect
Mammalian Phenotype (MP)incomplete somite formation0.0003201Highly InformativeDirect
Mammalian Phenotype (MP)scaly skin0.0006194Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01108Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.9899Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant3.662e-05InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0001255InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.01861Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.05472InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sensory perception defective4.541e-09InformativeDirect
Fly Phenotype (FP)neurophysiology defective7.795e-07InformativeDirect
Fly Phenotype (FP)gravitaxis defective0.0006762Highly InformativeDirect
Fly Phenotype (FP)temperature response defective0.007054Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)