SUPERFAMILY 1.75 HMM library and genome assignments server

Ankyrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Families:   Ankyrin repeat [ 48404] (17)


Superfamily statistics
Genomes (1,781) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 78,407 110,305 42
Proteins 67,730 94,099 42


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)localization10.6004Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.043331Least InformativeInherited
Biological Process (BP)developmental process0.0083620.002024Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0071040.00000005491Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)regulation of cellular process0.047791Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.73280.003364Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0021420.8131Least InformativeInherited
Biological Process (BP)negative regulation of cellular process0.000014840.000315Moderately InformativeDirect
Biological Process (BP)regulation of localization0.67550.0006784Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.016980.4386Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.10640.7462Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.013060.08188Moderately InformativeInherited
Biological Process (BP)response to organic substance0.90161Moderately InformativeInherited
Biological Process (BP)multi-organism process0.76250.0495Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.17951Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.82230.3376Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.85020.1627Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.036940.9444Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.78130.8952Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.013430.7852Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function11Moderately InformativeInherited
Biological Process (BP)immune system process0.12841Moderately InformativeInherited
Biological Process (BP)organ development0.51341Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.33450.0003708Moderately InformativeInherited
Biological Process (BP)cellular localization0.39380.1779Moderately InformativeInherited
Biological Process (BP)regulation of phosphorus metabolic process0.057370.1769Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.0024410.9727Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.02170.04464Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0051021Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.61190.8222Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.20980.3744Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.033590.9908Moderately InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.30650.6675InformativeInherited
Biological Process (BP)regulation of cell cycle process0.46090.3574InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.047890.3719InformativeInherited
Biological Process (BP)negative regulation of catalytic activity0.00071560.02836InformativeInherited
Biological Process (BP)response to lipid0.082350.2048InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.18710.04275InformativeInherited
Biological Process (BP)response to bacterium0.020230.000454InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.00018830.04892InformativeInherited
Biological Process (BP)mitotic cell cycle0.37491InformativeInherited
Biological Process (BP)negative regulation of cell communication0.21880.002592InformativeInherited
Biological Process (BP)negative regulation of signaling0.12840.0006117InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.41530.234InformativeInherited
Biological Process (BP)regulation of protein localization0.044760.405InformativeInherited
Biological Process (BP)negative regulation of transport0.23860.206InformativeInherited
Biological Process (BP)regulation of intracellular transport0.013420.2968InformativeInherited
Biological Process (BP)regulation of cytokine production0.065510.2017InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.081620.05147InformativeInherited
Biological Process (BP)negative regulation of multicellular organismal process0.45550.6063InformativeInherited
Biological Process (BP)organelle fission0.020470.0000003342InformativeInherited
Biological Process (BP)cell division0.046370.000001795InformativeInherited
Biological Process (BP)cell cycle process0.0000089890.15InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.00000017370.8329InformativeInherited
Biological Process (BP)regulation of transferase activity0.000003270.2744InformativeInherited
Biological Process (BP)negative regulation of intracellular transport0.00028470.000001413Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition0.0000000001510.000001935Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport0.000091040.00007129Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport0.00097290.0000009075Highly InformativeDirect
Biological Process (BP)maintenance of location0.000072010.0000004686Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus0.000076460.0000151Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus0.00051690.0001157Highly InformativeDirect
Biological Process (BP)negative regulation of mitotic cell cycle phase transition0.000000040570.0008373Highly InformativeDirect
Biological Process (BP)regulation of protein serine/threonine kinase activity0.0016820.1884Highly InformativeInherited
Biological Process (BP)negative regulation of protein phosphorylation0.000048530.01358Highly InformativeInherited
Biological Process (BP)negative regulation of transferase activity0.0000029480.06154Highly InformativeInherited
Biological Process (BP)response to lipopolysaccharide0.0010140.0001075Highly InformativeInherited
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.000085790.1013Highly InformativeInherited
Biological Process (BP)negative regulation of intracellular signal transduction0.00015320.02448Highly InformativeInherited
Biological Process (BP)regulation of protein targeting0.00041820.1089Highly InformativeInherited
Biological Process (BP)regulation of peptide transport0.0019750.8102Highly InformativeInherited
Biological Process (BP)negative regulation of cytokine production0.084270.0000429Highly InformativeInherited
Biological Process (BP)regulation of cytokine biosynthetic process0.013660.005747Highly InformativeInherited
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity0.00061990.002768Highly InformativeInherited
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway0.00000036160.194Highly InformativeInherited
Biological Process (BP)regulation of cellular response to growth factor stimulus0.0000016090.7206Highly InformativeInherited
Biological Process (BP)nuclear division0.044590.00005867Highly InformativeInherited
Biological Process (BP)meiotic cell cycle0.040030.000000001726Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.00047690.00003573Moderately InformativeDirect
Molecular Function (MF)enzyme binding0.00000000023250.000000004637InformativeDirect
Molecular Function (MF)enzyme inhibitor activity0.00070010.002111InformativeInherited
Molecular Function (MF)protein kinase regulator activity00.000000008621Highly InformativeDirect
Molecular Function (MF)transcription factor binding0.000035630.07311Highly InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.74030.000006134Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)extracellular region part11Moderately InformativeInherited
Cellular Component (CC)cell projection0.089020.0000000001449Moderately InformativeInherited
Cellular Component (CC)cell junction0.050920.00000000009565InformativeInherited
Cellular Component (CC)neuron projection0.0082710.0217InformativeInherited
Cellular Component (CC)contractile fiber part0.0016830.0000000000000118InformativeInherited
Cellular Component (CC)cell-cell contact zone0.000012690.00004527Highly InformativeDirect
Cellular Component (CC)main axon0.00000710.4423Highly InformativeInherited
Cellular Component (CC)sarcomere0.00056440.007362Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00000005491 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.003364 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.8131 Least Informative Inherited
Biological Process (BP) developmental process 0.002024 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.6004 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0.0000003592 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00006299 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0006784 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0003708 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000315 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4386 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1627 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1779 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.9444 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7462 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3376 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2261 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.04464 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7852 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8952 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.05773 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4281 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.01526 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.001676 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.9727 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.1769 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.8222 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.08188 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.0495 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.07409 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.3744 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.531 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) defense response 0.8493 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.9908 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0.0004428 Informative Direct
Biological Process (BP) response to bacterium 0.000454 Informative Direct
Biological Process (BP) sexual reproduction 0.000002376 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0006117 Informative Direct
Biological Process (BP) metal ion transport 0.0003356 Informative Direct
Biological Process (BP) cell projection organization 0.00000000000001071 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000000003726 Informative Direct
Biological Process (BP) growth 0.0004759 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000256 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000688 Informative Direct
Biological Process (BP) single-organism behavior 0.00000000009361 Informative Direct
Biological Process (BP) organelle fission 0.0000003342 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.00000004464 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00007918 Informative Direct
Biological Process (BP) cell division 0.000001795 Informative Direct
Biological Process (BP) regulation of nervous system development 0.000001747 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.00001152 Informative Direct
Biological Process (BP) epithelium development 0.0001374 Informative Direct
Biological Process (BP) muscle structure development 0.0005274 Informative Direct
Biological Process (BP) generation of neurons 0.1367 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.3574 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.6675 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1551 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.001682 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.1441 Informative Inherited
Biological Process (BP) secretion by cell 0.1914 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.3719 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.02836 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.04275 Informative Inherited
Biological Process (BP) ion transmembrane transport 0.09666 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.04892 Informative Inherited
Biological Process (BP) tube development 0.2873 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.03726 Informative Inherited
Biological Process (BP) regulation of cell development 0.325 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) blood circulation 0.007493 Informative Inherited
Biological Process (BP) muscle system process 0.1852 Informative Inherited
Biological Process (BP) cation homeostasis 0.01614 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.8457 Informative Inherited
Biological Process (BP) synaptic transmission 0.05316 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) regulation of growth 0.2195 Informative Inherited
Biological Process (BP) actin filament-based process 0.02238 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.405 Informative Inherited
Biological Process (BP) negative regulation of transport 0.206 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.234 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6063 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.05147 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.4169 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.9289 Informative Inherited
Biological Process (BP) positive regulation of RNA metabolic process 0.7568 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.04391 Informative Inherited
Biological Process (BP) regulation of ion transport 0.1526 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.001916 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.1933 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.7276 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.5159 Informative Inherited
Biological Process (BP) tetrapyrrole metabolic process 0.005604 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.987 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.9359 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.7923 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.2017 Informative Inherited
Biological Process (BP) response to lipid 0.2048 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.6297 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.7343 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.002592 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.6782 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.7165 Informative Inherited
Biological Process (BP) organelle assembly 1 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.2596 Informative Inherited
Biological Process (BP) positive regulation of transport 0.0656 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) neurological system process 0.03092 Informative Inherited
Biological Process (BP) organ morphogenesis 0.3094 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.2114 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.001873 Informative Inherited
Biological Process (BP) locomotion 0.5218 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.00119 Informative Inherited
Biological Process (BP) cellular component movement 0.9326 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.2968 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.7529 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.5826 Informative Inherited
Biological Process (BP) immune response 0.2392 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7563 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) cell cycle process 0.15 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.2744 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.8329 Informative Inherited
Biological Process (BP) protein transport 0.03015 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.9521 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) nuclear division 0.00005867 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00009596 Highly Informative Direct
Biological Process (BP) negative regulation of cytokine production 0.0000429 Highly Informative Direct
Biological Process (BP) DNA modification 0 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 0.0002743 Highly Informative Direct
Biological Process (BP) striated muscle contraction 0.0003249 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0.00001172 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.000000003901 Highly Informative Direct
Biological Process (BP) sensory perception 0.0008065 Highly Informative Direct
Biological Process (BP) response to heat 0.0004119 Highly Informative Direct
Biological Process (BP) cell growth 0.00000000003414 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.00002672 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.0007264 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.000001413 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0001075 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.0001366 Highly Informative Direct
Biological Process (BP) regulation of ion transmembrane transport 0.0000000002333 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.000000001316 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0.000001918 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.00003533 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.000001935 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0003482 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.00007129 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.000318 Highly Informative Direct
Biological Process (BP) developmental growth 0.000001106 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.00004389 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.0001192 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.0000009075 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000004686 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.000000001726 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0.0001223 Highly Informative Direct
Biological Process (BP) heart contraction 0.0000000001354 Highly Informative Direct
Biological Process (BP) myeloid cell development 0.0001078 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0000151 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.00005911 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.0003008 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0001157 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.0008373 Highly Informative Direct
Biological Process (BP) response to nerve growth factor 0.0000001231 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0.9912 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.856 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.5149 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.1884 Highly Informative Inherited
Biological Process (BP) negative regulation of protein phosphorylation 0.01358 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.06154 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.0588 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.0575 Highly Informative Inherited
Biological Process (BP) histone modification 0.3857 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.01372 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.005907 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.293 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.5616 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.003179 Highly Informative Inherited
Biological Process (BP) response to transition metal nanoparticle 0.2277 Highly Informative Inherited
Biological Process (BP) protein methylation 1 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.004256 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.6893 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.1013 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.2253 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.01472 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.003919 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.02448 Highly Informative Inherited
Biological Process (BP) regulation of protein targeting 0.1089 Highly Informative Inherited
Biological Process (BP) ensheathment of neurons 0.001676 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.8102 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.005747 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 0.7914 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.4069 Highly Informative Inherited
Biological Process (BP) epidermis development 0.001108 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.7213 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.1435 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.09734 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.001383 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.4549 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.1294 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.4622 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.8775 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.02819 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.0023 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.78 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.002768 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.1097 Highly Informative Inherited
Biological Process (BP) DNA replication 1 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.01934 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 1 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.04966 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.194 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.7206 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.114 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.008113 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.7247 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.7164 Highly Informative Inherited
Biological Process (BP) learning or memory 0.02686 Highly Informative Inherited
Biological Process (BP) germ cell development 0.1331 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.994 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.1664 Highly Informative Inherited
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 0.4747 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) glutamine family amino acid catabolic process 0.006596 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.7755 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.3791 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.4971 Highly Informative Inherited
Biological Process (BP) protein import 0.2785 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.3723 Highly Informative Inherited
Biological Process (BP) single-organism nuclear import 0.1963 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0009908 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.00003573 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.09665 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.000003578 Informative Direct
Molecular Function (MF) enzyme binding 0.000000004637 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.1848 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.1336 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.002111 Informative Inherited
Molecular Function (MF) phosphatase activity 0.8969 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.4828 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) ubiquitin-protein transferase activity 0.000001725 Highly Informative Direct
Molecular Function (MF) cation channel activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.0000009887 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.000000008621 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.0007532 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.00004086 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.000897 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.07311 Highly Informative Inherited
Molecular Function (MF) methyltransferase activity 0.9778 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.09733 Highly Informative Inherited
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.7192 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 0.4892 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.03594 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.1381 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.000006134 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.0000000001449 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.2759 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.5748 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.6312 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.1312 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0.00002391 Informative Direct
Cellular Component (CC) cell junction 0.00000000009565 Informative Direct
Cellular Component (CC) contractile fiber part 0.0000000000000118 Informative Direct
Cellular Component (CC) synapse 0.0000000002711 Informative Direct
Cellular Component (CC) endosome 0.09422 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.01705 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) neuron projection 0.0217 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.3745 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) adherens junction 0.0000000002649 Highly Informative Direct
Cellular Component (CC) cytoplasmic ribonucleoprotein granule 0.000000000006709 Highly Informative Direct
Cellular Component (CC) cell-cell contact zone 0.00004527 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00004166 Highly Informative Direct
Cellular Component (CC) ciliary part 0.5448 Highly Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.05774 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.01776 Highly Informative Inherited
Cellular Component (CC) main axon 0.4423 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.007362 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.9342 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.4016Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1213Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.000000001232Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0008122Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001342Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3822Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.000000000000344InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0.0000000000002201Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)benign neoplasm0.01858Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.1766InformativeInherited
Disease Ontology (DO)skin hemangioma0.00000499Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.2036Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.0511InformativeInherited
Phenotypic Abnormality (PA)Melanoma0.0001142Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.3089Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5447Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.04524Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.3096Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.04076InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.2595InformativeInherited
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0001618Highly InformativeDirect
Mammalian Phenotype (MP)incomplete somite formation0.0002624Highly InformativeDirect
Mammalian Phenotype (MP)scaly skin0.0005642Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01108Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.9899Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.00003662InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0001255InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.01861Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

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YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.05443InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

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