SUPERFAMILY 1.75 HMM library and genome assignments server


Ankyrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Families:   Ankyrin repeat [ 48404] (17)


Superfamily statistics
Genomes (1,780) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 77,215 110,305 42
Proteins 66,626 94,099 42


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization10.2995Least InformativeInherited
Biological Process (BP)single-organism cellular process0.77550.06962Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.74470.1946Least InformativeInherited
Biological Process (BP)developmental process0.0055650.001217Least InformativeInherited
Biological Process (BP)regulation of cellular process0.020871Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0078522.261e-07Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0010380.7376Least InformativeInherited
Biological Process (BP)single-organism developmental process0.00015513.941e-11Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process4.484e-050.000106Moderately InformativeDirect
Biological Process (BP)regulation of localization0.64110.004059Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.013430.8243Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.05778Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.15650.7725Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.60410.8388Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.073221Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function11Moderately InformativeInherited
Biological Process (BP)immune system process0.11640.9757Moderately InformativeInherited
Biological Process (BP)organ development0.68180.869Moderately InformativeInherited
Biological Process (BP)cellular localization0.3520.0186Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.32260.001692Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.75250.1065Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.00041451Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.025431Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.17921Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.03750.1454Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.23970.1087Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.87661Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0044840.6733Moderately InformativeInherited
Biological Process (BP)cell cycle process6.354e-062.264e-08InformativeDirect
Biological Process (BP)regulation of establishment of protein localization0.39240.0119InformativeInherited
Biological Process (BP)regulation of intracellular transport0.012980.1475InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.00047950.003368InformativeInherited
Biological Process (BP)negative regulation of catalytic activity0.00084560.04408InformativeInherited
Biological Process (BP)negative regulation of transport0.22020.1337InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.00022130.1023InformativeInherited
Biological Process (BP)mitotic cell cycle0.13961InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.50381InformativeInherited
Biological Process (BP)regulation of cytokine production0.051250.1146InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.12870.03499InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.49920.5175InformativeInherited
Biological Process (BP)regulation of protein phosphorylation1.037e-071InformativeInherited
Biological Process (BP)regulation of kinase activity4.808e-100.8538InformativeInherited
Biological Process (BP)negative regulation of intracellular transport0.0001674.9e-07Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation5.728e-050.0004212Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition1.329e-102.334e-05Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport8.087e-050.0001171Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport0.00084721.006e-06Highly InformativeDirect
Biological Process (BP)maintenance of location1.559e-052.832e-09Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus0.00062127.287e-05Highly InformativeDirect
Biological Process (BP)regulation of intracellular protein transport0.01280.001431Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process1.008e-050.09926Highly InformativeInherited
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.00020790.05986Highly InformativeInherited
Biological Process (BP)regulation of cytokine biosynthetic process0.02020.006338Highly InformativeInherited
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity0.036320.01702Highly InformativeInherited
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway2.628e-070.1552Highly InformativeInherited
Biological Process (BP)regulation of cellular response to growth factor stimulus1.328e-060.7004Highly InformativeInherited
Biological Process (BP)negative regulation of cell cycle8.677e-070.002652Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.0012260.003416Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity0.00016484.65e-05InformativeDirect
Molecular Function (MF)enzyme binding1.323e-101.265e-08InformativeDirect
Molecular Function (MF)protein kinase regulator activity06.206e-09Highly InformativeDirect
Molecular Function (MF)transcription factor binding2.827e-050.074Highly InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.62983.482e-07Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)extracellular region part11Moderately InformativeInherited
Cellular Component (CC)cell projection0.23857.923e-07Moderately InformativeInherited
Cellular Component (CC)cell junction0.050197.799e-11InformativeInherited
Cellular Component (CC)neuron projection0.0048274.3e-05InformativeInherited
Cellular Component (CC)contractile fiber part0.001598.985e-15InformativeInherited
Cellular Component (CC)cell-cell contact zone1.211e-054.366e-05Highly InformativeDirect
Cellular Component (CC)main axon6.774e-060.4885Highly InformativeInherited
Cellular Component (CC)sarcomere0.00053390.00723Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 2.261e-07 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.1946 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.7376 Least Informative Inherited
Biological Process (BP) localization 0.2995 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.06962 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.001217 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) ion transport 3.5e-10 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0009541 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 4.876e-05 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 3.941e-11 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000106 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0367 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.004059 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.6794 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7725 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.05778 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5164 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6733 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1454 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8243 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9757 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.176 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2946 Moderately Informative Inherited
Biological Process (BP) system process 0.001199 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1551 Moderately Informative Inherited
Biological Process (BP) reproduction 0.04487 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.0186 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.001692 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.1087 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1065 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.7249 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8388 Moderately Informative Inherited
Biological Process (BP) organ development 0.869 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 7.038e-06 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0004969 Informative Direct
Biological Process (BP) protein transport 0.0002479 Informative Direct
Biological Process (BP) sexual reproduction 1.805e-06 Informative Direct
Biological Process (BP) cell cycle process 2.264e-08 Informative Direct
Biological Process (BP) negative regulation of signaling 9.853e-05 Informative Direct
Biological Process (BP) cell projection organization 1.018e-13 Informative Direct
Biological Process (BP) cellular component morphogenesis 4.28e-14 Informative Direct
Biological Process (BP) growth 0.0003677 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 2.531e-05 Informative Direct
Biological Process (BP) single organism reproductive process 1.898e-09 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 5.658e-05 Informative Direct
Biological Process (BP) cellular process involved in reproduction 7.827e-06 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0001473 Informative Direct
Biological Process (BP) regulation of nervous system development 1.253e-06 Informative Direct
Biological Process (BP) transmembrane transport 0.0009517 Informative Direct
Biological Process (BP) muscle tissue development 8.668e-06 Informative Direct
Biological Process (BP) muscle structure development 4.157e-08 Informative Direct
Biological Process (BP) generation of neurons 0.1255 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.4445 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.9072 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.0119 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1475 Informative Inherited
Biological Process (BP) cellular membrane organization 0.01894 Informative Inherited
Biological Process (BP) secretion by cell 0.1846 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.8289 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.003368 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.04408 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.139 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.9818 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.4672 Informative Inherited
Biological Process (BP) response to lipid 0.5112 Informative Inherited
Biological Process (BP) response to other organism 0.257 Informative Inherited
Biological Process (BP) metal ion transport 0.03382 Informative Inherited
Biological Process (BP) cardiovascular system development 0.685 Informative Inherited
Biological Process (BP) tube development 0.09133 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) blood circulation 0.00671 Informative Inherited
Biological Process (BP) cation homeostasis 0.009683 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.08411 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.7076 Informative Inherited
Biological Process (BP) actin filament-based process 0.0401 Informative Inherited
Biological Process (BP) regulation of system process 0.164 Informative Inherited
Biological Process (BP) synaptic transmission 0.7063 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.1023 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.01179 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) organelle assembly 0.7474 Informative Inherited
Biological Process (BP) DNA metabolic process 0.05599 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.1146 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.03499 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2095 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.03868 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.9497 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.9347 Informative Inherited
Biological Process (BP) epithelium development 0.5666 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.001639 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.1946 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.7527 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.9886 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.03655 Informative Inherited
Biological Process (BP) positive regulation of transport 0.2078 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.6021 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.6029 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.5175 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.7739 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) regulation of growth 0.0997 Informative Inherited
Biological Process (BP) regulation of cell development 0.05765 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.5731 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.4445 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.4554 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.001974 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) locomotion 0.4899 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1337 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.07033 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7084 Informative Inherited
Biological Process (BP) muscle system process 0.03968 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) immune response 0.2183 Informative Inherited
Biological Process (BP) defense response 0.953 Informative Inherited
Biological Process (BP) response to wounding 0.9018 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.8538 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0003787 Highly Informative Direct
Biological Process (BP) DNA modification 0 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 0.0002563 Highly Informative Direct
Biological Process (BP) striated muscle contraction 0.0003096 Highly Informative Direct
Biological Process (BP) meiosis 1.452e-11 Highly Informative Direct
Biological Process (BP) spermatogenesis 2.198e-09 Highly Informative Direct
Biological Process (BP) muscle organ development 3.345e-07 Highly Informative Direct
Biological Process (BP) sensory perception 8.691e-08 Highly Informative Direct
Biological Process (BP) response to heat 0.0003683 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 5.725e-05 Highly Informative Direct
Biological Process (BP) cell growth 6.232e-11 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 6.384e-06 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 3.091e-05 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 4.9e-07 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 1.124e-11 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 2.847e-12 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 1.158e-09 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 1.821e-06 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0004212 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 1.303e-06 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 2.334e-05 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0001833 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0001171 Highly Informative Direct
Biological Process (BP) developmental growth 1.112e-05 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 1.97e-05 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 1.006e-06 Highly Informative Direct
Biological Process (BP) maintenance of location 2.832e-09 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0.0001095 Highly Informative Direct
Biological Process (BP) heart contraction 1.217e-10 Highly Informative Direct
Biological Process (BP) myeloid cell development 9.776e-05 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 7.287e-05 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.0008655 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.7666 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.4738 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.001431 Highly Informative Inherited
Biological Process (BP) renal system development 0.04859 Highly Informative Inherited
Biological Process (BP) cell cycle phase 0.02459 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.7005 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.09926 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.05672 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.007597 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.002816 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.0533 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.2049 Highly Informative Inherited
Biological Process (BP) protein methylation 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.3606 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.01068 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.5467 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.05986 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.01251 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.001722 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.2292 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.001149 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.02089 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.01955 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.2956 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.2108 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.004 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.1246 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.006338 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.7053 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.5384 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.04653 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.8927 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.001445 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.444 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.1242 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.9535 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0481 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.001998 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.811 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.01702 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.9674 Highly Informative Inherited
Biological Process (BP) DNA replication 1 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.02237 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.99 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.06278 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.1552 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.7004 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.004929 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.719 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.6732 Highly Informative Inherited
Biological Process (BP) learning or memory 0.009693 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.001115 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.9875 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.9787 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.002652 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) glutamine family amino acid catabolic process 0.006365 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.7623 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.3513 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.1123 Highly Informative Inherited
Biological Process (BP) protein import 0.2182 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.5459 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.9858 Highly Informative Inherited
Biological Process (BP) nuclear import 0.2825 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0004862 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.08995 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.003416 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 4.65e-05 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 3.494e-06 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.0004539 Informative Direct
Molecular Function (MF) enzyme binding 1.265e-08 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 9.192e-11 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.0194 Informative Inherited
Molecular Function (MF) lipid binding 0.1081 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.1204 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.3478 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.4635 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) cation channel activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) channel regulator activity 7.687e-07 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 1.683e-06 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 6.206e-09 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.0004328 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.074 Highly Informative Inherited
Molecular Function (MF) glycolipid binding 0.002242 Highly Informative Inherited
Molecular Function (MF) methyltransferase activity 0.9556 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.08858 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.03128 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.2416 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.7222 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 0.1717 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.1342 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 3.482e-07 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cell projection 7.923e-07 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.9353 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.6191 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.02996 Moderately Informative Inherited
Cellular Component (CC) cell cortex 1.616e-05 Informative Direct
Cellular Component (CC) cell junction 7.799e-11 Informative Direct
Cellular Component (CC) neuron projection 4.3e-05 Informative Direct
Cellular Component (CC) contractile fiber part 8.985e-15 Informative Direct
Cellular Component (CC) synapse part 2.152e-07 Informative Direct
Cellular Component (CC) endosome 0.08271 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.0216 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.1009 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) adherens junction 2.169e-10 Highly Informative Direct
Cellular Component (CC) cell-cell contact zone 4.366e-05 Highly Informative Direct
Cellular Component (CC) membrane raft 0.0002803 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 2.719e-05 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0.05408 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.01684 Highly Informative Inherited
Cellular Component (CC) main axon 0.4885 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.00723 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.9115 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.4016Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1213Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1.232e-09Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0008122Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001342Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3822Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase3.44e-13InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase2.201e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)benign neoplasm0.01768Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.1751InformativeInherited
Disease Ontology (DO)skin hemangioma4.979e-06Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.2037Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.05122InformativeInherited
Phenotypic Abnormality (PA)Melanoma0.0001157Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.2324Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4425Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.03488Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2294Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.04452InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.3356InformativeInherited
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0002145Highly InformativeDirect
Mammalian Phenotype (MP)incomplete somite formation0.0002917Highly InformativeDirect
Mammalian Phenotype (MP)scaly skin0.0005982Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01108Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.9899Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant3.662e-05InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0001255InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.01861Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

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YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.05457InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sensory perception defective1.028e-08InformativeDirect
Fly Phenotype (FP)neurophysiology defective1.935e-06InformativeDirect
Fly Phenotype (FP)temperature response defective0.0001645Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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