SUPERFAMILY 1.75 HMM library and genome assignments server


GTPase activation domain, GAP superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GTPase activation domain, GAP [ 48349]
Superfamily:   GTPase activation domain, GAP [ 48350] (2)
Families:   BCR-homology GTPase activation domain (BH-domain) [ 48351] (5)
  p120GAP domain-like [ 48360] (2)


Superfamily statistics
Genomes (506) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,408 16,705 10
Proteins 15,253 16,608 10


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.0002289.978e-11Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.25490.001864Least InformativeInherited
Biological Process (BP)single-organism cellular process0.093090Least InformativeInherited
Biological Process (BP)positive regulation of molecular function1.083e-050Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity5.723e-050Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00013874.974e-09Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.054890Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process3.617e-080InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process1.234e-070InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity1.895e-070InformativeDirect
Biological Process (BP)regulation of cellular catabolic process4.877e-070InformativeDirect
Biological Process (BP)locomotion6.388e-050InformativeDirect
Biological Process (BP)cellular component movement0.00037054.389e-11InformativeDirect
Biological Process (BP)regulation of Rho GTPase activity1.187e-112.894e-10Highly InformativeDirect
Biological Process (BP)positive regulation of Ras GTPase activity1.198e-104.125e-09Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity4.423e-060Moderately InformativeDirect
Molecular Function (MF)GTPase regulator activity4.012e-090InformativeDirect
Molecular Function (MF)enzyme activator activity0.015120InformativeInherited
Molecular Function (MF)small GTPase regulator activity5.553e-111.413e-07Highly InformativeDirect
Molecular Function (MF)GTPase activator activity0.0015470Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 9.978e-11 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 8.018e-14 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.001864 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) localization 0.001002 Least Informative Inherited
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 4.974e-09 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.769e-13 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 7.572e-10 Moderately Informative Direct
Biological Process (BP) nervous system development 2.418e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001286 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.01787 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9955 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.05025 Moderately Informative Inherited
Biological Process (BP) system process 0.7344 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4376 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.07024 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1164 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.5843 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.4204 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8685 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cellular component movement 4.389e-11 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 4.792e-14 Informative Direct
Biological Process (BP) regulation of locomotion 4.223e-12 Informative Direct
Biological Process (BP) regulation of cell development 1.172e-11 Informative Direct
Biological Process (BP) regulation of nervous system development 4.115e-10 Informative Direct
Biological Process (BP) cell projection organization 9.605e-10 Informative Direct
Biological Process (BP) glycerolipid metabolic process 1.679e-09 Informative Direct
Biological Process (BP) regulation of anatomical structure size 4.405e-09 Informative Direct
Biological Process (BP) localization of cell 1.23e-08 Informative Direct
Biological Process (BP) phospholipid metabolic process 8.409e-08 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 1.26e-07 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.637e-07 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 1.229e-06 Informative Direct
Biological Process (BP) epithelium development 2.344e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0003747 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.1609 Informative Inherited
Biological Process (BP) organelle assembly 0.7822 Informative Inherited
Biological Process (BP) cell cycle process 0.3154 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1404 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.4607 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.08972 Informative Inherited
Biological Process (BP) microtubule-based process 0.4674 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.3101 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.5464 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2604 Informative Inherited
Biological Process (BP) synaptic transmission 0.003274 Informative Inherited
Biological Process (BP) regulation of defense response 0.8591 Informative Inherited
Biological Process (BP) dephosphorylation 0.0483 Informative Inherited
Biological Process (BP) phosphorylation 0.9161 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.2058 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.06047 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.7346 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.843 Informative Inherited
Biological Process (BP) negative regulation of transport 0.01852 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.1889 Informative Inherited
Biological Process (BP) growth 0.02587 Informative Inherited
Biological Process (BP) single-organism behavior 0.08301 Informative Inherited
Biological Process (BP) regulation of growth 0.8565 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.5538 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.2053 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.2348 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.6374 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.05949 Informative Inherited
Biological Process (BP) biological adhesion 0.001554 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.05487 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) generation of neurons 0.0913 Informative Inherited
Biological Process (BP) central nervous system development 0.01297 Informative Inherited
Biological Process (BP) tube development 0.03541 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.2087 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.3168 Informative Inherited
Biological Process (BP) organ morphogenesis 0.009188 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.08423 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.9892 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.5706 Informative Inherited
Biological Process (BP) cardiovascular system development 0.3912 Informative Inherited
Biological Process (BP) regulation of Rho GTPase activity 2.894e-10 Highly Informative Direct
Biological Process (BP) positive regulation of Ras GTPase activity 4.125e-09 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 3.77e-15 Highly Informative Direct
Biological Process (BP) chemotaxis 1.091e-14 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 2.709e-13 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 7.914e-12 Highly Informative Direct
Biological Process (BP) lipid modification 1.477e-08 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 5.69e-08 Highly Informative Direct
Biological Process (BP) limb morphogenesis 2.197e-05 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 4.475e-05 Highly Informative Direct
Biological Process (BP) neural tube development 5.786e-05 Highly Informative Direct
Biological Process (BP) cell junction organization 7.886e-05 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 9.523e-05 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.000111 Highly Informative Direct
Biological Process (BP) cell division 0.0001538 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.00018 Highly Informative Direct
Biological Process (BP) learning or memory 0.0002461 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.0004617 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0005011 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0005636 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0006379 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.0007285 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.003272 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.03321 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.02167 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.6363 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.6614 Highly Informative Inherited
Biological Process (BP) spindle organization 0.07425 Highly Informative Inherited
Biological Process (BP) mitosis 0.3434 Highly Informative Inherited
Biological Process (BP) renal system development 0.1366 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.5582 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.102 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.2859 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.07231 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02855 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.005047 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.6766 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.01355 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis 0.01442 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.02462 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.5473 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.2086 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.1583 Highly Informative Inherited
Biological Process (BP) negative regulation of cell activation 0.1049 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 0.02945 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.04362 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.2484 Highly Informative Inherited
Biological Process (BP) cell growth 0.009877 Highly Informative Inherited
Biological Process (BP) developmental growth 0.7159 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.03604 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.1792 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.008668 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.0015 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.1822 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.4708 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.1866 Highly Informative Inherited
Biological Process (BP) regulation of cyclic nucleotide metabolic process 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.04949 Highly Informative Inherited
Biological Process (BP) axon development 0.3441 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.002514 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.003083 Highly Informative Inherited
Molecular Function (MF) binding 1.198e-05 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 2.77e-05 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.8986 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.449 Moderately Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) enzyme binding 8.965e-10 Informative Direct
Molecular Function (MF) lipid binding 3.214e-06 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0.1108 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) receptor activity 0.001134 Informative Inherited
Molecular Function (MF) receptor binding 0.4 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.002242 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.3384 Informative Inherited
Molecular Function (MF) small GTPase regulator activity 1.413e-07 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 2.926e-06 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.2946 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.02908 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 6.77e-07 Least Informative Direct
Cellular Component (CC) membrane 0.0009864 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.2517 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) cell projection 3.895e-11 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1.787e-08 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.004591 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell cortex 9.131e-15 Informative Direct
Cellular Component (CC) actin cytoskeleton 8.609e-05 Informative Direct
Cellular Component (CC) synapse part 0.0008051 Informative Direct
Cellular Component (CC) neuron projection 0.9375 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) cell division site part 8.31e-11 Highly Informative Direct
Cellular Component (CC) midbody 0.0008818 Highly Informative Direct
Cellular Component (CC) receptor complex 0.02763 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.4455Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.4383Moderately InformativeInherited
Disease Ontology (DO)polycythemia0.0005763Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0004326Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5902Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.3332InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.4144InformativeInherited
Phenotypic Abnormality (PA)Short attention span0.001266Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperactivity0.005502Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.02659Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.05434Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.5524Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7422Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.7657Moderately InformativeInherited
Mammalian Phenotype (MP)ectopic neuron0.01789InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.8969InformativeInherited
Mammalian Phenotype (MP)ectopic cerebellar granule cells2.171e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.0003228Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ear development0.0009387Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology0.03485Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.1217Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.03338Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.0817InformativeInherited
Worm Phenotype (WP)cleavage furrow defective early emb7.01e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.4055Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.5148Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.1249Moderately InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.002545Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups0.03139Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1.45e-09Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1.181e-05Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase3.021e-06InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation4.986e-07Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis1.753e-12InformativeDirect
Cellular componentMembrane3.781e-13Least InformativeDirect
Cellular componentCytoplasm0.03951Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle6.428e-16Moderately InformativeDirect
Cellular componentEndosome2.066e-10Moderately InformativeDirect
Cellular componentCytoskeleton5.292e-10Moderately InformativeDirect
Cellular componentGolgi apparatus1.691e-07Moderately InformativeDirect
Coding sequence diversityAlternative splicing1.238e-06Least InformativeDirect
DiseaseTumor suppressor1.088e-10Moderately InformativeDirect
DomainRepeat2.458e-06Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger8.97e-07Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding6.286e-14InformativeDirect
DomainLIM domain3.079e-05Highly InformativeDirect
Molecular functionZinc1.021e-05Least InformativeDirect
Molecular functionCalmodulin-binding8.493e-09InformativeDirect
Molecular functionActin-binding0.0002049InformativeDirect
Post-translational modificationDevelopmental protein1.897e-11Moderately InformativeDirect
Post-translational modificationReceptor2.107e-05Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationMyosin1.281e-07Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008936 SSF48350 Protein matches
Abstract

Proteins containing a RhoGAP (Rho GTPase Activating Protein) domain usually function to catalyze the hydrolysis of GTP that is bound to Rho, Rac and/or Cdc42, inactivating these regulators of the actin cytoskeleton. The 53 known human RhoGAP domain-containing proteins are the largest known group of Rho GTPase regulators and significantly outnumber the 21 Rho GTPases they presumably regulate. This excess of GAP proteins probably indicates complex regulation of the Rho GTPases and is consistent with the existence of almost as many (48) human Dbl domain-containing Rho GEFs that act antagonistically to the RhoGAP proteins by activating the Rho GTPases. Phylogenetic analysis offers evidence for frequent domain duplication and for duplication of the entire genes containing these GAP domains [PubMed12297274].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GTPase activation domain, GAP domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the GTPase activation domain, GAP superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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