SUPERFAMILY 1.75 HMM library and genome assignments server


GTPase activation domain, GAP superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GTPase activation domain, GAP [ 48349]
Superfamily:   GTPase activation domain, GAP [ 48350] (2)
Families:   BCR-homology GTPase activation domain (BH-domain) [ 48351] (5)
  p120GAP domain-like [ 48360] (2)


Superfamily statistics
Genomes (451) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 14,022 12,644 10
Proteins 13,868 12,561 10


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process3.481e-052.169e-05Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.22890.002999Least InformativeInherited
Biological Process (BP)regulation of signaling0.00061440Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.00041210Moderately InformativeDirect
Biological Process (BP)regulation of nitrogen compound metabolic process6.125e-057.243e-13Moderately InformativeDirect
Biological Process (BP)regulation of cellular metabolic process0.12115.193e-06Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.0014590Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.004650Moderately InformativeInherited
Biological Process (BP)regulation of cellular catabolic process6.09e-080InformativeDirect
Biological Process (BP)locomotion3.192e-050InformativeDirect
Biological Process (BP)positive regulation of catalytic activity7.482e-070InformativeDirect
Biological Process (BP)regulation of hydrolase activity5.898e-070InformativeDirect
Biological Process (BP)regulation of nucleoside metabolic process1.675e-090Highly InformativeDirect
Biological Process (BP)regulation of purine nucleotide catabolic process1.374e-093.329e-14Highly InformativeDirect
Biological Process (BP)regulation of Ras protein signal transduction0.69061Highly InformativeInherited
Molecular Function (MF)enzyme regulator activity3.21e-060Moderately InformativeDirect
Molecular Function (MF)GTPase regulator activity1.525e-090InformativeDirect
Molecular Function (MF)enzyme activator activity0.011380InformativeInherited
Molecular Function (MF)small GTPase regulator activity1.895e-119.463e-07Highly InformativeDirect
Molecular Function (MF)GTPase activator activity0.0016190Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 2.368e-09 Least Informative Direct
Biological Process (BP) developmental process 2.076e-15 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 2.169e-05 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.002999 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) localization 0.02392 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) nervous system development 4.752e-06 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 9.092e-12 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 5.193e-06 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.015e-05 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 1.536e-05 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 7.243e-13 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.9947 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.7168 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.001386 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.6921 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.7098 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1706 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) system process 0.7288 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.06732 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.1078 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.6611 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.04298 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 1.726e-07 Informative Direct
Biological Process (BP) cellular component movement 0.000567 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 1.092e-11 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) cell projection organization 1.382e-09 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0002078 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 4.599e-11 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 3.32e-09 Informative Direct
Biological Process (BP) regulation of cellular component movement 2.28e-10 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) localization of cell 1.21e-08 Informative Direct
Biological Process (BP) regulation of nervous system development 6.031e-08 Informative Direct
Biological Process (BP) regulation of cell development 1.158e-14 Informative Direct
Biological Process (BP) epithelium development 4.571e-05 Informative Direct
Biological Process (BP) regulation of anatomical structure size 1.261e-09 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.9241 Informative Inherited
Biological Process (BP) regulation of protein localization 0.4975 Informative Inherited
Biological Process (BP) response to external stimulus 0.04032 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.06552 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.02112 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.02436 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) dephosphorylation 0.0068 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.6321 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.07667 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.01943 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.1114 Informative Inherited
Biological Process (BP) growth 0.06488 Informative Inherited
Biological Process (BP) single-organism behavior 0.06658 Informative Inherited
Biological Process (BP) regulation of growth 0.9972 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.9272 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.9126 Informative Inherited
Biological Process (BP) response to organic nitrogen 0.5212 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.3998 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.09347 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.3196 Informative Inherited
Biological Process (BP) response to lipid 0.3578 Informative Inherited
Biological Process (BP) response to other organism 0.7901 Informative Inherited
Biological Process (BP) biological adhesion 0.002281 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.005613 Informative Inherited
Biological Process (BP) positive regulation of phosphorus metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) generation of neurons 0.1988 Informative Inherited
Biological Process (BP) central nervous system development 0.007552 Informative Inherited
Biological Process (BP) tube development 0.07242 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.151 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.3097 Informative Inherited
Biological Process (BP) organ morphogenesis 0.09939 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1178 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.293 Informative Inherited
Biological Process (BP) chordate embryonic development 0.4538 Informative Inherited
Biological Process (BP) cardiovascular system development 0.4668 Informative Inherited
Biological Process (BP) cell cycle process 0.4118 Informative Inherited
Biological Process (BP) chemotaxis 2.897e-12 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0005743 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) learning or memory 0.0002212 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0002509 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis 5.08e-07 Highly Informative Direct
Biological Process (BP) lipid modification 9.981e-09 Highly Informative Direct
Biological Process (BP) regulation of cell projection organization 8.047e-07 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0009358 Highly Informative Direct
Biological Process (BP) regulation of cellular component size 4.202e-11 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 3.329e-14 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.0003702 Highly Informative Direct
Biological Process (BP) tube formation 8.422e-06 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 1.598e-12 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.0003343 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 1.158e-14 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0009075 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 3.457e-11 Highly Informative Direct
Biological Process (BP) cell division 0.0001085 Highly Informative Direct
Biological Process (BP) regulation of neuron differentiation 0.4759 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.03448 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.6337 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.6801 Highly Informative Inherited
Biological Process (BP) kidney development 0.1509 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.3737 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.1775 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.002718 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.492 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.01389 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.6144 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.04468 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.137 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.03516 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.253 Highly Informative Inherited
Biological Process (BP) cell growth 0.01411 Highly Informative Inherited
Biological Process (BP) developmental growth 0.8458 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.1757 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.03932 Highly Informative Inherited
Biological Process (BP) regulation of Ras protein signal transduction 1 Highly Informative Inherited
Biological Process (BP) response to insulin stimulus 0.001017 Highly Informative Inherited
Biological Process (BP) cellular response to peptide hormone stimulus 0.001465 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.1416 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.6197 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.3093 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.01985 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.006345 Highly Informative Inherited
Biological Process (BP) axonogenesis 0.6323 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.00196 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.3625 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.008107 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 8.95e-15 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.9573 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.6222 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) enzyme binding 7.622e-10 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0.1531 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) receptor activity 0.0123 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.02501 Informative Inherited
Molecular Function (MF) lipid binding 0.08751 Informative Inherited
Molecular Function (MF) receptor binding 0.3683 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.4572 Informative Inherited
Molecular Function (MF) small GTPase regulator activity 9.463e-07 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.07484 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.428 Least Informative Inherited
Cellular Component (CC) membrane 0.01449 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.004238 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1.612e-06 Moderately Informative Direct
Cellular Component (CC) cell projection 4.228e-10 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.2407 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.002593 Moderately Informative Inherited
Cellular Component (CC) cell cortex 5.376e-10 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.000162 Informative Direct
Cellular Component (CC) cell junction 3.035e-07 Informative Direct
Cellular Component (CC) cell leading edge 6.149e-15 Informative Direct
Cellular Component (CC) cell projection part 2.618e-05 Informative Direct
Cellular Component (CC) neuron part 0.0002944 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.02299 Informative Inherited
Cellular Component (CC) ruffle 1.413e-08 Highly Informative Direct
Cellular Component (CC) adherens junction 0.0002552 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 1.178e-07 Highly Informative Direct
Cellular Component (CC) midbody 0.0006212 Highly Informative Direct
Cellular Component (CC) cell division site part 5.751e-11 Highly Informative Direct
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.07546 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.02081 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.4902Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.4347Moderately InformativeInherited
Disease Ontology (DO)polycythemia0.0004409Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0002731Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.05362Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1051Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1439Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.9502Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hindbrain morphology0.481InformativeInherited
Mammalian Phenotype (MP)ectopic cerebellar granule cells2.212e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ear development0.0006585Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology0.01323Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.1217Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.03338Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.0817InformativeInherited
Worm Phenotype (WP)cleavage furrow defective early emb7.01e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.002736Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups0.03239Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1.446e-09Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1.272e-05Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase3.257e-06InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation2.194e-07Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis8.619e-09InformativeDirect
Cellular componentMembrane2.426e-12Least InformativeDirect
Cellular componentCytoplasm0.0423Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCytoskeleton8.228e-11Moderately InformativeDirect
Cellular componentEndosome2.342e-08Moderately InformativeDirect
Cellular componentGolgi apparatus6.763e-08Moderately InformativeDirect
Cellular componentPostsynaptic cell membrane0.0002229InformativeDirect
Coding sequence diversityAlternative splicing8.627e-06Least InformativeDirect
DiseaseTumor suppressor3.088e-11Moderately InformativeDirect
DomainRepeat5.285e-06Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding6.214e-14InformativeDirect
Molecular functionZinc2.794e-06Least InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionZinc-finger0Moderately InformativeDirect
Molecular functionCalmodulin-binding5.524e-09InformativeDirect
Molecular functionActin-binding0.0005918InformativeDirect
Molecular functionLIM domain7.237e-06Highly InformativeDirect
Post-translational modificationDevelopmental protein6.863e-09Moderately InformativeDirect
Post-translational modificationReceptor2.041e-05Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationMyosin7.97e-08Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008936 SSF48350 Protein matches
Abstract

Proteins containing a RhoGAP (Rho GTPase Activating Protein) domain usually function to catalyze the hydrolysis of GTP that is bound to Rho, Rac and/or Cdc42, inactivating these regulators of the actin cytoskeleton. The 53 known human RhoGAP domain-containing proteins are the largest known group of Rho GTPase regulators and significantly outnumber the 21 Rho GTPases they presumably regulate. This excess of GAP proteins probably indicates complex regulation of the Rho GTPases and is consistent with the existence of almost as many (48) human Dbl domain-containing Rho GEFs that act antagonistically to the RhoGAP proteins by activating the Rho GTPases. Phylogenetic analysis offers evidence for frequent domain duplication and for duplication of the entire genes containing these GAP domains [PubMed12297274].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GTPase activation domain, GAP domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the GTPase activation domain, GAP superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]