SUPERFAMILY 1.75 HMM library and genome assignments server


GTPase activation domain, GAP superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GTPase activation domain, GAP [ 48349]
Superfamily:   GTPase activation domain, GAP [ 48350] (2)
Families:   BCR-homology GTPase activation domain (BH-domain) [ 48351] (5)
  p120GAP domain-like [ 48360] (2)


Superfamily statistics
Genomes (455) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 14,184 12,644 10
Proteins 14,030 12,561 10


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process5.457e-051.802e-10Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.26910.004005Least InformativeInherited
Biological Process (BP)single-organism cellular process0.025480Least InformativeInherited
Biological Process (BP)positive regulation of molecular function3.389e-060Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity2.83e-050Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process6.919e-051.353e-08Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.054370Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of nucleotide catabolic process1.547e-080InformativeDirect
Biological Process (BP)regulation of nucleoside metabolic process1.695e-080InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity2.337e-080InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process5.994e-080InformativeDirect
Biological Process (BP)locomotion3.309e-050InformativeDirect
Biological Process (BP)cellular component movement0.00035131.186e-10InformativeDirect
Biological Process (BP)regulation of Rho protein signal transduction9.309e-122.392e-09Highly InformativeDirect
Biological Process (BP)positive regulation of GTPase activity9.722e-110Highly InformativeDirect
Biological Process (BP)regulation of Ras GTPase activity1.439e-102.724e-08Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity2.372e-060Moderately InformativeDirect
Molecular Function (MF)GTPase regulator activity1.943e-090InformativeDirect
Molecular Function (MF)enzyme activator activity0.016060InformativeInherited
Molecular Function (MF)small GTPase regulator activity2.756e-112.4e-07Highly InformativeDirect
Molecular Function (MF)GTPase activator activity0.0014650Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1.802e-10 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0.000721 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.173e-13 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.004005 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1.353e-08 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 6.697e-06 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 5.398e-12 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 4.33e-10 Moderately Informative Direct
Biological Process (BP) nervous system development 7.861e-06 Moderately Informative Direct
Biological Process (BP) regulation of localization 6.805e-05 Moderately Informative Direct
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.5903 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.04096 Moderately Informative Inherited
Biological Process (BP) system process 0.5576 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5698 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.531 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.4841 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9437 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.87 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.01425 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.052 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.9299 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.08269 Moderately Informative Inherited
Biological Process (BP) regulation of nucleotide catabolic process 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cellular component movement 1.186e-10 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 7.645e-14 Informative Direct
Biological Process (BP) regulation of locomotion 7.347e-12 Informative Direct
Biological Process (BP) regulation of cell development 9.042e-11 Informative Direct
Biological Process (BP) glycerolipid metabolic process 8.821e-10 Informative Direct
Biological Process (BP) cell projection organization 1.071e-09 Informative Direct
Biological Process (BP) regulation of nervous system development 3.091e-09 Informative Direct
Biological Process (BP) regulation of anatomical structure size 3.385e-08 Informative Direct
Biological Process (BP) localization of cell 4.322e-08 Informative Direct
Biological Process (BP) phospholipid metabolic process 5.287e-08 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 1.052e-07 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 4.947e-07 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 7.64e-06 Informative Direct
Biological Process (BP) epithelium development 3.95e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0001571 Informative Direct
Biological Process (BP) biological adhesion 0.0007685 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.1559 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.8082 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.09895 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.3554 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.3557 Informative Inherited
Biological Process (BP) response to nutrient levels 0.4956 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.4124 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1387 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.3798 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.4599 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.6985 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.8733 Informative Inherited
Biological Process (BP) regulation of defense response 0.8014 Informative Inherited
Biological Process (BP) dephosphorylation 0.0381 Informative Inherited
Biological Process (BP) phosphorylation 0.8582 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.1508 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.0685 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.6968 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.7213 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.1581 Informative Inherited
Biological Process (BP) growth 0.00409 Informative Inherited
Biological Process (BP) single-organism behavior 0.08174 Informative Inherited
Biological Process (BP) regulation of growth 0.8253 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.46 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.2202 Informative Inherited
Biological Process (BP) response to lipid 0.3062 Informative Inherited
Biological Process (BP) response to bacterium 0.3323 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.9961 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) generation of neurons 0.1514 Informative Inherited
Biological Process (BP) central nervous system development 0.008483 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1228 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.2738 Informative Inherited
Biological Process (BP) organ morphogenesis 0.01408 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.118 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.9489 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.4603 Informative Inherited
Biological Process (BP) cardiovascular system development 0.5073 Informative Inherited
Biological Process (BP) cell cycle process 0.2809 Informative Inherited
Biological Process (BP) regulation of Rho protein signal transduction 2.392e-09 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 2.724e-08 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 1.931e-15 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 6.527e-13 Highly Informative Direct
Biological Process (BP) chemotaxis 8.753e-13 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 2.075e-11 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 4.438e-09 Highly Informative Direct
Biological Process (BP) lipid modification 9.949e-09 Highly Informative Direct
Biological Process (BP) tube formation 5.987e-06 Highly Informative Direct
Biological Process (BP) neural tube development 3.261e-05 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 5.29e-05 Highly Informative Direct
Biological Process (BP) cell division 6.553e-05 Highly Informative Direct
Biological Process (BP) cell junction organization 7.98e-05 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0001176 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0002677 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0003536 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0005063 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0005631 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0005903 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.0006939 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.0007353 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.001975 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.06827 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.002221 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.02393 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.6843 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.6918 Highly Informative Inherited
Biological Process (BP) renal system development 0.1019 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.5451 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.006866 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.001226 Highly Informative Inherited
Biological Process (BP) fruiting body development 0.002471 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.09109 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.1997 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.2422 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.1653 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.006448 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.01067 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.004253 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.578 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.01141 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis 0.01216 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.5699 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.1231 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.1848 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.04776 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.2484 Highly Informative Inherited
Biological Process (BP) cell growth 0.008356 Highly Informative Inherited
Biological Process (BP) developmental growth 0.6136 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.03058 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.1673 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.1344 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.5319 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.4803 Highly Informative Inherited
Biological Process (BP) regulation of cyclic nucleotide metabolic process 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.04191 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02821 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.001764 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.4352 Highly Informative Inherited
Molecular Function (MF) binding 4.681e-06 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 8.591e-06 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.8403 Moderately Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) enzyme binding 3.803e-10 Informative Direct
Molecular Function (MF) lipid binding 2.931e-06 Informative Direct
Molecular Function (MF) phosphatase activity 0.02023 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) receptor activity 0.003101 Informative Inherited
Molecular Function (MF) receptor binding 0.3659 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.006071 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.2761 Informative Inherited
Molecular Function (MF) small GTPase regulator activity 2.4e-07 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.2781 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.02313 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1.301e-07 Least Informative Direct
Cellular Component (CC) membrane 0.0006466 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.1118 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) cell projection 3.11e-11 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 4.181e-09 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.1955 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell cortex 1.386e-12 Informative Direct
Cellular Component (CC) actin cytoskeleton 9.698e-05 Informative Direct
Cellular Component (CC) synapse part 0.0003662 Informative Direct
Cellular Component (CC) neuron projection 0.9051 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) cell division site part 4.217e-11 Highly Informative Direct
Cellular Component (CC) ruffle 1.721e-08 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 9.9e-08 Highly Informative Direct
Cellular Component (CC) contractile ring 1.068e-05 Highly Informative Direct
Cellular Component (CC) actin filament 0.0006015 Highly Informative Direct
Cellular Component (CC) midbody 0.000675 Highly Informative Direct
Cellular Component (CC) adherens junction 0.002991 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.2564 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.02169 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.4182Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.4371Moderately InformativeInherited
Disease Ontology (DO)polycythemia0.0005137Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0004169Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5879Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.3348InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.4154InformativeInherited
Phenotypic Abnormality (PA)Short attention span0.001304Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperactivity0.005587Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.01857Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.05838Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2114Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.8755Moderately InformativeInherited
Mammalian Phenotype (MP)ectopic neuron0.01877InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.8932InformativeInherited
Mammalian Phenotype (MP)ectopic cerebellar granule cells2.066e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ear development0.0009175Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology0.02597Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.1217Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.03338Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.0817InformativeInherited
Worm Phenotype (WP)cleavage furrow defective early emb7.01e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.3966Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.5129Least InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.002657Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups0.03237Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1.538e-09Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1.228e-05Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase3.141e-06InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation4.57e-07Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis1.802e-12InformativeDirect
Cellular componentMembrane3.945e-13Least InformativeDirect
Cellular componentCytoplasm0.03427Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle3.21e-16Moderately InformativeDirect
Cellular componentEndosome1.974e-10Moderately InformativeDirect
Cellular componentCytoskeleton5.079e-10Moderately InformativeDirect
Cellular componentGolgi apparatus1.617e-07Moderately InformativeDirect
Coding sequence diversityAlternative splicing3.96e-06Least InformativeDirect
DiseaseTumor suppressor1.258e-10Moderately InformativeDirect
DomainRepeat2.667e-06Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger8.789e-07Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding6.797e-14InformativeDirect
DomainLIM domain3.098e-05Highly InformativeDirect
Molecular functionZinc9.447e-06Least InformativeDirect
Molecular functionCalmodulin-binding8.836e-09InformativeDirect
Molecular functionActin-binding0.0001962InformativeDirect
Post-translational modificationDevelopmental protein1.927e-11Moderately InformativeDirect
Post-translational modificationReceptor2.162e-05Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationMyosin1.318e-07Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008936 SSF48350 Protein matches
Abstract

Proteins containing a RhoGAP (Rho GTPase Activating Protein) domain usually function to catalyze the hydrolysis of GTP that is bound to Rho, Rac and/or Cdc42, inactivating these regulators of the actin cytoskeleton. The 53 known human RhoGAP domain-containing proteins are the largest known group of Rho GTPase regulators and significantly outnumber the 21 Rho GTPases they presumably regulate. This excess of GAP proteins probably indicates complex regulation of the Rho GTPases and is consistent with the existence of almost as many (48) human Dbl domain-containing Rho GEFs that act antagonistically to the RhoGAP proteins by activating the Rho GTPases. Phylogenetic analysis offers evidence for frequent domain duplication and for duplication of the entire genes containing these GAP domains [PubMed12297274].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GTPase activation domain, GAP domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the GTPase activation domain, GAP superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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