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Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [ 48339]
Superfamily:   Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [ 48340]
Families:   Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [ 48341]


Superfamily statistics
Genomes (254) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,366 1,407 1
Proteins 1,335 1,378 1


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.010210.0000000001419Least InformativeInherited
Biological Process (BP)response to stimulus0.004640.0000000006214Least InformativeInherited
Biological Process (BP)immune system process0.000013350Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.000030070Moderately InformativeDirect
Biological Process (BP)response to organic substance0.000046550Moderately InformativeDirect
Biological Process (BP)response to cytokine stimulus0.00000006940InformativeDirect
Biological Process (BP)immune response0.0000014780InformativeDirect
Biological Process (BP)defense response0.000008130InformativeDirect
Biological Process (BP)innate immune response0.00000035950Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0000000006214 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000000001419 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.03706 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.03471 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.007424 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01593 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.008603 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.02519 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000000000008921 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.000000002556 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 0.000000005995 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.00000002253 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.00000003419 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0000002925 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0000004477 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.000002505 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00001426 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0002278 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.9265 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.07764 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.3765 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.4134 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.207 Moderately Informative Inherited
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) protein oligomerization 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) response to other organism 0 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0.000000000002855 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.000000000004181 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.000000000009053 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.00000000001617 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.00000000003031 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.00000000003387 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.0000000005117 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.4154 Informative Inherited
Biological Process (BP) generation of neurons 0.03954 Informative Inherited
Biological Process (BP) cell projection organization 0.3722 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.02831 Informative Inherited
Biological Process (BP) response to lipid 0.2586 Informative Inherited
Biological Process (BP) innate immune response 0 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0.0000000000008305 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.000000000001472 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.000000000001776 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000000000009034 Highly Informative Direct
Biological Process (BP) defense response to bacterium 0.000001039 Highly Informative Direct
Biological Process (BP) neuron projection development 0.002162 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.006444 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.002669 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0007268 Least Informative Direct
Molecular Function (MF) binding 0.03895 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.000000003036 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0000009731 Moderately Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.0000000002181 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.000000001269 Informative Direct
Molecular Function (MF) nucleotide binding 0.000000008609 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.002056 Informative Inherited
Cellular Component (CC) cytoplasmic part 0.000000000000001594 Least Informative Direct
Cellular Component (CC) membrane 0.1031 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.00000000000006156 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000000007267 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.0000001179 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.000002015 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.00275 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.05437 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 0.00000000000008305 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.00007637 Informative Direct
Cellular Component (CC) Golgi apparatus 0.01478 Informative Inherited

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntiviral defense0.000000000005459Highly InformativeDirect
Cellular componentMembrane0.00000000000006529Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell projection0.00000008327Moderately InformativeDirect
DomainTransmembrane0.00003644Least InformativeDirect
DomainCoiled coil0.0000000000002819Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationHydrolase0.00001336Least InformativeDirect
Post-translational modificationAntimicrobial0.0000000001773InformativeDirect
Post-translational modificationMethylation0.000001187Moderately InformativeDirect
Post-translational modificationPrenylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015900 SSF48340 Protein matches
Abstract

Guanylate-binding protein is a GTPase that is induced by interferon (IFN)-gamma. GTPases induced by IFN-gamma are key to the protective immunity against microbial and viral pathogens. These GTPases are classified into three groups: the small 47-kd GTPases, the Mx proteins, and the large 65- to 67-kd GTPases. Guanylate-binding proteins (GBP) fall into the last class. In humans, there are seven GBPs (hGBP1-7) [PubMed17266443]. Structurally, hGBP1 consists of two domains: a compact globular N-terminal domain harbouring the GTPase function , and an alpha-helical finger-like C-terminal domain. Human GBP1 is secreted from cells without the need of a leader peptide, and has been shown to exhibit antiviral activity against Vesicular stomatitis virus and Encephalomyocarditis virus, as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to IFN-gamma [PubMed16936281].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]