SUPERFAMILY 1.75 HMM library and genome assignments server


Cytochrome P450 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Families:   Cytochrome P450 [ 48265] (22)


Superfamily statistics
Genomes (1,305) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 57,787 77,510 76
Proteins 56,408 76,848 76


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process1.988e-100Least InformativeDirect
Biological Process (BP)single-organism metabolic process1.428e-120Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00083280Least InformativeDirect
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus0.27851Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.16011Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)lipid biosynthetic process1.16e-100Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process2.514e-110Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process2.091e-060Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus8.502e-076.172e-08Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process6.474e-060Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process6.807e-130Moderately InformativeDirect
Biological Process (BP)regulation of developmental process3.878e-051Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.14080.2498Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.036451Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0022381Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus1.773e-060.8373Moderately InformativeInherited
Biological Process (BP)response to organic substance0.010151Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0031331Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0064191Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.015521Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process6.411e-051Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.00071761Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process2.864e-051Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.047821Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.00013011Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.00058351Moderately InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process0.016860.8684Moderately InformativeInherited
Biological Process (BP)homeostatic process0.45611Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process7.123e-120InformativeDirect
Biological Process (BP)regulation of hormone levels1.724e-060InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process1.199e-100.0002407InformativeDirect
Biological Process (BP)regulation of apoptotic process5.232e-061InformativeInherited
Biological Process (BP)response to cytokine stimulus7.801e-070.04233InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.65181InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.97231InformativeInherited
Biological Process (BP)response to lipid0.94560.03716InformativeInherited
Biological Process (BP)response to organic cyclic compound0.74753.392e-06InformativeInherited
Biological Process (BP)regulation of response to external stimulus7.27e-100.001151InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0015986.378e-11InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis2.883e-050.7489InformativeInherited
Biological Process (BP)positive regulation of developmental process3.223e-100.4111InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process4.213e-071InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process1.462e-091InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.065311.085e-14InformativeInherited
Biological Process (BP)positive regulation of signal transduction3.318e-071InformativeInherited
Biological Process (BP)regulation of defense response3.326e-090.1047InformativeInherited
Biological Process (BP)negative regulation of response to stimulus9.828e-080.7611InformativeInherited
Biological Process (BP)secondary metabolic process0.019453.752e-15InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.059370.2031InformativeInherited
Biological Process (BP)glycosyl compound biosynthetic process0.19920.01705InformativeInherited
Biological Process (BP)vitamin metabolic process0.38452.183e-11InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.24891.976e-09InformativeInherited
Biological Process (BP)lipid catabolic process0.0020655.488e-07InformativeInherited
Biological Process (BP)response to hypoxia1.229e-133.238e-05Highly InformativeDirect
Biological Process (BP)icosanoid metabolic process1.17e-120Highly InformativeDirect
Biological Process (BP)steroid biosynthetic process2.319e-100Highly InformativeDirect
Biological Process (BP)steroid catabolic process5.073e-091.114e-13Highly InformativeDirect
Biological Process (BP)xenobiotic metabolic process5.409e-060Highly InformativeDirect
Biological Process (BP)sterol metabolic process0.00022219.766e-07Highly InformativeDirect
Biological Process (BP)glycoside metabolic process4.184e-059.697e-07Highly InformativeDirect
Biological Process (BP)antibiotic biosynthetic process9.63e-060.0001204Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus04.108e-07Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid metabolic process1.173e-080Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process0.00030860Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process7.376e-070Highly InformativeDirect
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity02.102e-12Highly InformativeDirect
Biological Process (BP)regulation of nitric oxide biosynthetic process09.136e-15Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis02.619e-07Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.00018031.304e-05Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process4.919e-141.085e-14Highly InformativeDirect
Biological Process (BP)response to alcohol0.56770.003169Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus0.074970.303Highly InformativeInherited
Biological Process (BP)carbohydrate homeostasis0.010670.2433Highly InformativeInherited
Biological Process (BP)regulation of cellular ketone metabolic process0.010360.09923Highly InformativeInherited
Biological Process (BP)alcohol biosynthetic process0.14424.558e-08Highly InformativeInherited
Biological Process (BP)polyol metabolic process11Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.16320.0006346Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)isomerase activity2.117e-070.008151Moderately InformativeInherited
Molecular Function (MF)intramolecular oxidoreductase activity3.275e-155.611e-13InformativeDirect
Molecular Function (MF)tetrapyrrole binding00InformativeDirect
Molecular Function (MF)monooxygenase activity00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge00Highly InformativeDirect
Molecular Function (MF)heme binding00Highly InformativeDirect
Cellular Component (CC)membrane0.91161Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.991Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum3.534e-120Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.35861Moderately InformativeInherited
Cellular Component (CC)membrane raft04.854e-05Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) lipid biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 6.172e-08 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8373 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.2498 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.3302 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.3287 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.06275 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.8684 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9881 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) fatty acid metabolic process 6.378e-11 Informative Direct
Biological Process (BP) isoprenoid metabolic process 1.976e-09 Informative Direct
Biological Process (BP) vitamin metabolic process 2.183e-11 Informative Direct
Biological Process (BP) regulation of hormone levels 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 3.392e-06 Informative Direct
Biological Process (BP) lipid catabolic process 5.488e-07 Informative Direct
Biological Process (BP) secondary metabolic process 3.752e-15 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0002407 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 1.085e-14 Informative Direct
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.04233 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to lipid 0.03716 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7489 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.4111 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.006151 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.3765 Informative Inherited
Biological Process (BP) regulation of defense response 0.1047 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.7611 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001151 Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.008859 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.2031 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.01705 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.4055 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6324 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.03666 Informative Inherited
Biological Process (BP) blood circulation 0.001198 Informative Inherited
Biological Process (BP) response to hypoxia 3.238e-05 Highly Informative Direct
Biological Process (BP) tryptophan metabolic process 7.429e-06 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) steroid catabolic process 1.114e-13 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 1.142e-05 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 4.436e-05 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0 Highly Informative Direct
Biological Process (BP) response to toxic substance 4.158e-05 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 1.09e-06 Highly Informative Direct
Biological Process (BP) sterol metabolic process 9.766e-07 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 9.697e-07 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.0001204 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 4.108e-07 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) quinone cofactor metabolic process 9.236e-08 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 0.0003538 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 3.58e-05 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 2.102e-12 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0006346 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 9.136e-15 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 2.619e-07 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 4.558e-08 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 1.304e-05 Highly Informative Direct
Biological Process (BP) regulation of coagulation 4.916e-05 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.000481 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 3.033e-05 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 1.085e-14 Highly Informative Direct
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.003169 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.303 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.2433 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.09923 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.2081 Highly Informative Inherited
Biological Process (BP) response to drug 0.0104 Highly Informative Inherited
Biological Process (BP) quinone biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 1 Highly Informative Inherited
Biological Process (BP) retinoid metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.68 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 0.1944 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.9631 Highly Informative Inherited
Biological Process (BP) external encapsulating structure organization 0.051 Highly Informative Inherited
Biological Process (BP) lipid modification 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.634 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.008151 Moderately Informative Inherited
Molecular Function (MF) intramolecular oxidoreductase activity 5.611e-13 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 2.892e-06 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.03774 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) membrane raft 4.854e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7611Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.02235InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)With a reduced iron-sulfur protein as one donor, a1.495e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)endocrine system disease0.02106Moderately InformativeInherited
Disease Ontology (DO)artery disease0.1134Moderately InformativeInherited
Disease Ontology (DO)bone disease0.1182Moderately InformativeInherited
Disease Ontology (DO)physical disorder0.03837InformativeInherited
Disease Ontology (DO)coronary artery disease0.587InformativeInherited
Disease Ontology (DO)hypospadias5.824e-05Highly InformativeDirect
Disease Ontology (DO)bone resorption disease0.0001186Highly InformativeDirect
Disease Ontology (DO)hyperandrogenism0.0002119Highly InformativeDirect
Disease Ontology (DO)thoracic disease0.0003875Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.07053InformativeInherited
Phenotypic Abnormality (PA)Adrenogenital syndrome7.977e-06Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.3353Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8371Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.01066Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1021Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1719Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2029Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.3286Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.5865Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure1.517e-05InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.08323InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.4336InformativeInherited
Mammalian Phenotype (MP)abnormal xenobiotic pharmacokinetics3.083e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0003762Highly InformativeDirect
Mammalian Phenotype (MP)abnormal uterus morphology0.006891Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating aldosterone level0.7063Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.2164Least InformativeInherited
Worm Phenotype (WP)metal response variant0.0001096InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.04137Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1163Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2501Least InformativeInherited
Fly Anatomy (FA)organ system0.2617Least InformativeInherited
Fly Anatomy (FA)cell0.5769Least InformativeInherited
Fly Anatomy (FA)larva0.5972Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.00428Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01212Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.03212Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.134Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.3716Moderately InformativeInherited
Fly Anatomy (FA)head0.439Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.5252Moderately InformativeInherited
Fly Anatomy (FA)commissure6.53e-06InformativeDirect
Fly Anatomy (FA)digestive system0.0004858InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.0006539InformativeDirect
Fly Anatomy (FA)embryonic/larval integumentary system0.009012InformativeInherited
Fly Anatomy (FA)primordium0.02098InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.1144InformativeInherited
Fly Anatomy (FA)hindgut2.172e-06Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath4.741e-06Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system1.081e-05Highly InformativeDirect
Fly Anatomy (FA)midgut primordium7.154e-05Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.0001087Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0004038Highly InformativeDirect
Fly Anatomy (FA)glial cell0.000639Highly InformativeDirect
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0008415Highly InformativeDirect

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.01248InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0.1225Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.9078InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases4.814e-16Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor8.037e-05Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.002589Highly InformativeInherited
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.01611Highly InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processFatty acid metabolism1InformativeInherited
Biological processLipid biosynthesis1InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processGrowth regulation8.284e-11Highly InformativeDirect
Biological processAntibiotic biosynthesis3.528e-09Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMicrosome0Highly InformativeDirect
Coding sequence diversityPolymorphism4.147e-06Moderately InformativeDirect
DiseaseDisease mutation0.0001163Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide5.253e-07Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionLipid-binding0.3712InformativeInherited
Molecular functionSteroid-binding5.079e-09Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.7188Least InformativeInherited
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis1.957e-10Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism2.032e-05Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)antibiotic biosynthesis0InformativeDirect
UniPathway (UP)alkaloid metabolism0InformativeDirect
UniPathway (UP)terpene metabolism0InformativeDirect
UniPathway (UP)alcohol biosynthesis0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)toxin biosynthesis4.514e-16InformativeDirect
UniPathway (UP)pigment biosynthesis0.0008518InformativeDirect
UniPathway (UP)hormone biosynthesis0.004204InformativeInherited
UniPathway (UP)plant hormone metabolism0.4951InformativeInherited
UniPathway (UP)flavonoid metabolism0.9951InformativeInherited
UniPathway (UP)mycotoxin biosynthesis0Highly InformativeDirect
UniPathway (UP)oxylipin biosynthesis1.038e-11Highly InformativeDirect
UniPathway (UP)anthocyanin biosynthesis6.119e-10Highly InformativeDirect
UniPathway (UP)erythromycin biosynthesis0.0007678Highly InformativeDirect
UniPathway (UP)steroid hormone biosynthesis0.1378Highly InformativeInherited
UniPathway (UP)monoterpene metabolism0.5763Highly InformativeInherited
UniPathway (UP)plant hormone biosynthesis0.8316Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001128 SSF48264 Protein matches
Abstract

More information about these proteins can be found at Protein of the Month: Cytochrome P450.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the Cytochrome P450 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]