SUPERFAMILY 1.75 HMM library and genome assignments server


Cytochrome P450 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Families:   Cytochrome P450 [ 48265] (22)


Superfamily statistics
Genomes (1,047) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 46,514 51,241 76
Proteins 45,799 50,837 76


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process7.635e-070Least InformativeDirect
Biological Process (BP)single-organism metabolic process9.727e-140Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.0009580Least InformativeDirect
Biological Process (BP)single-organism cellular process0.33721Least InformativeInherited
Biological Process (BP)response to stimulus0.0020240.0002399Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0029121Least InformativeInherited
Biological Process (BP)regulation of cellular process0.27971Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)lipid biosynthetic process2.261e-100Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process3.417e-110Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process1.499e-070Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process6.8e-071.032e-06Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus9.675e-090Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.00012190Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process8.104e-120Moderately InformativeDirect
Biological Process (BP)regulation of developmental process1.069e-071Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.16780.6099Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00055581Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0014010.6975Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus1.954e-070.06721Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0062521Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression4.814e-051Moderately InformativeInherited
Biological Process (BP)regulation of molecular function5.566e-051Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process0.0024671Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process3.131e-071Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.00048881Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process2.724e-061Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process2.871e-071Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.0015241Moderately InformativeInherited
Biological Process (BP)homeostatic process0.54111Moderately InformativeInherited
Biological Process (BP)regulation of cell communication5.367e-061Moderately InformativeInherited
Biological Process (BP)regulation of signaling4.837e-061Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.00015291Moderately InformativeInherited
Biological Process (BP)cellular catabolic process10.9516Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.4081Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.93281Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process1.457e-090InformativeDirect
Biological Process (BP)steroid metabolic process00InformativeDirect
Biological Process (BP)regulation of hormone levels3.61e-060InformativeDirect
Biological Process (BP)regulation of response to external stimulus1.049e-122.126e-08InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process2.663e-110.0003945InformativeDirect
Biological Process (BP)regulation of response to stress9.993e-100.0004478InformativeDirect
Biological Process (BP)regulation of apoptotic process6.232e-081InformativeInherited
Biological Process (BP)response to cytokine stimulus1.689e-070.03031InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.9441InformativeInherited
Biological Process (BP)response to lipid0.93990.04559InformativeInherited
Biological Process (BP)response to organic cyclic compound0.83.688e-05InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis3.524e-050.2517InformativeInherited
Biological Process (BP)positive regulation of developmental process3.629e-130.03912InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process6.909e-071InformativeInherited
Biological Process (BP)negative regulation of cellular metabolic process3.608e-071InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process1.169e-111InformativeInherited
Biological Process (BP)positive regulation of signal transduction1.506e-100.2263InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0024855.747e-09InformativeInherited
Biological Process (BP)negative regulation of molecular function4.329e-110.003249InformativeInherited
Biological Process (BP)negative regulation of response to stimulus6.507e-110.003565InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.059020.01889InformativeInherited
Biological Process (BP)vitamin metabolic process0.28843.303e-11InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.224.233e-09InformativeInherited
Biological Process (BP)lipid catabolic process0.001311.213e-05InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process0.0018092.688e-05InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.49820.9941InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.59480.00229InformativeInherited
Biological Process (BP)response to hypoxia1.598e-152.427e-08Highly InformativeDirect
Biological Process (BP)steroid biosynthetic process8.148e-080Highly InformativeDirect
Biological Process (BP)steroid catabolic process7.386e-091.469e-12Highly InformativeDirect
Biological Process (BP)xenobiotic metabolic process4.035e-060Highly InformativeDirect
Biological Process (BP)drug metabolic process0.00022270Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus07.334e-08Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid metabolic process7.613e-090Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process1.672e-070Highly InformativeDirect
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity03.543e-13Highly InformativeDirect
Biological Process (BP)regulation of nitric oxide biosynthetic process00Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis01.083e-08Highly InformativeDirect
Biological Process (BP)icosanoid biosynthetic process6.608e-103.856e-07Highly InformativeDirect
Biological Process (BP)regulation of inflammatory response00.0003986Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process4.152e-056.103e-07Highly InformativeDirect
Biological Process (BP)lipid homeostasis2.632e-099.55e-08Highly InformativeDirect
Biological Process (BP)cellular response to organic cyclic compound0.69120.9975Highly InformativeInherited
Biological Process (BP)cellular response to alcohol0.10380.02219Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus0.085270.282Highly InformativeInherited
Biological Process (BP)regulation of cellular ketone metabolic process0.026740.0009802Highly InformativeInherited
Biological Process (BP)sterol metabolic process0.0049450.1389Highly InformativeInherited
Biological Process (BP)alcohol catabolic process1.136e-050.006883Highly InformativeInherited
Biological Process (BP)cellular biogenic amine catabolic process0.094340.0003732Highly InformativeInherited
Biological Process (BP)indole-containing compound catabolic process0.027035.822e-06Highly InformativeInherited
Biological Process (BP)tryptophan metabolic process0.0011436.366e-08Highly InformativeInherited
Biological Process (BP)aromatic amino acid family catabolic process0.045436.746e-06Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)organic cyclic compound binding0.010083.551e-07Moderately InformativeInherited
Molecular Function (MF)heterocyclic compound binding0.0068035.14e-07Moderately InformativeInherited
Molecular Function (MF)isomerase activity1.9e-070.006832Moderately InformativeInherited
Molecular Function (MF)intramolecular oxidoreductase activity00InformativeDirect
Molecular Function (MF)monooxygenase activity00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge7.393e-130Highly InformativeDirect
Molecular Function (MF)heme binding2.608e-130Highly InformativeDirect
Cellular Component (CC)membrane0.061091Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.17340.6455Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.40860.6675Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum7.517e-150Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.022861.497e-13Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.033971Moderately InformativeInherited
Cellular Component (CC)membrane raft03.514e-07Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.0002399 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) lipid biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 1.032e-06 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.6975 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.06721 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.08351 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.6099 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.4355 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.2969 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9048 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9516 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 2.688e-05 Informative Direct
Biological Process (BP) fatty acid metabolic process 5.747e-09 Informative Direct
Biological Process (BP) isoprenoid metabolic process 4.233e-09 Informative Direct
Biological Process (BP) vitamin metabolic process 3.303e-11 Informative Direct
Biological Process (BP) blood circulation 3.773e-05 Informative Direct
Biological Process (BP) steroid metabolic process 0 Informative Direct
Biological Process (BP) regulation of hormone levels 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 3.688e-05 Informative Direct
Biological Process (BP) lipid catabolic process 1.213e-05 Informative Direct
Biological Process (BP) regulation of response to external stimulus 2.126e-08 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0003945 Informative Direct
Biological Process (BP) regulation of response to stress 0.0004478 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 4.455e-12 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.9941 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.03031 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to lipid 0.04559 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.0231 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.2517 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.03912 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.001015 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.2263 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.00229 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.003249 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.003565 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.01889 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.4713 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.06991 Informative Inherited
Biological Process (BP) anion transport 0.8167 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.9925 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.9011 Informative Inherited
Biological Process (BP) response to inorganic substance 0.8956 Informative Inherited
Biological Process (BP) response to other organism 0.3283 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.004006 Informative Inherited
Biological Process (BP) metal ion transport 0.1177 Informative Inherited
Biological Process (BP) transition metal ion transport 0.0005531 Highly Informative Direct
Biological Process (BP) response to hypoxia 2.427e-08 Highly Informative Direct
Biological Process (BP) tryptophan metabolic process 6.366e-08 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) steroid catabolic process 1.469e-12 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0002003 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 8.646e-06 Highly Informative Direct
Biological Process (BP) aromatic amino acid family catabolic process 6.746e-06 Highly Informative Direct
Biological Process (BP) toxin metabolic process 6.133e-08 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0008461 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 1.046e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.0009802 Highly Informative Direct
Biological Process (BP) drug metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 7.334e-08 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0 Highly Informative Direct
Biological Process (BP) quinone cofactor metabolic process 7.25e-07 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 0.0003732 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 7.072e-06 Highly Informative Direct
Biological Process (BP) indole-containing compound catabolic process 5.822e-06 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 3.543e-13 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 1.083e-08 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 4.432e-05 Highly Informative Direct
Biological Process (BP) icosanoid biosynthetic process 3.856e-07 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 0.0003986 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 6.103e-07 Highly Informative Direct
Biological Process (BP) lipid homeostasis 9.55e-08 Highly Informative Direct
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 0.9975 Highly Informative Inherited
Biological Process (BP) cellular response to alcohol 0.02219 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.282 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.1046 Highly Informative Inherited
Biological Process (BP) response to drug 0.0383 Highly Informative Inherited
Biological Process (BP) quinone biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid catabolic process 0.9354 Highly Informative Inherited
Biological Process (BP) retinoid metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.182 Highly Informative Inherited
Biological Process (BP) regulation of blood coagulation 0.002608 Highly Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.06775 Highly Informative Inherited
Biological Process (BP) sterol metabolic process 0.1389 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.006883 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 0.0193 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.3489 Highly Informative Inherited
Biological Process (BP) external encapsulating structure organization 0.002097 Highly Informative Inherited
Biological Process (BP) lipid modification 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.01548 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 3.551e-07 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 5.14e-07 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.006832 Moderately Informative Inherited
Molecular Function (MF) electron carrier activity 0.0007122 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.6455 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6675 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1.497e-13 Moderately Informative Direct
Cellular Component (CC) organelle membrane 2.71e-09 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) membrane raft 3.514e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7611Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.02235InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)With a reduced iron-sulfur protein as one donor, a1.495e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.412Least InformativeInherited
Disease Ontology (DO)vascular disease0.07264Moderately InformativeInherited
Disease Ontology (DO)brain disease0.2362Moderately InformativeInherited
Disease Ontology (DO)heart disease0.4654Moderately InformativeInherited
Disease Ontology (DO)myocardial infarction0.0008764InformativeDirect
Disease Ontology (DO)cerebrovascular disease0.05801InformativeInherited
Disease Ontology (DO)thoracic disease0.0004172Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.4716Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5703Least InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.06911Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3329Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.3488Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.5119Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.5819Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.0004459InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.06995InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.0892InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.3855InformativeInherited
Mammalian Phenotype (MP)abnormal xenobiotic pharmacokinetics5.5e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0003585Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aldosterone level0.0007939Highly InformativeDirect
Mammalian Phenotype (MP)abnormal uterus morphology0.006192Highly InformativeInherited
Mammalian Phenotype (MP)abnormal adrenal gland morphology0.007261Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.2164Least InformativeInherited
Worm Phenotype (WP)metal response variant0.0001096InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0434Least InformativeInherited
Fly Anatomy (FA)organ system0.2368Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2645Least InformativeInherited
Fly Anatomy (FA)cell0.5548Least InformativeInherited
Fly Anatomy (FA)larva0.5638Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01091Moderately InformativeInherited
Fly Anatomy (FA)anatomical group0.08421Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.2135Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.4031Moderately InformativeInherited
Fly Anatomy (FA)head0.4541Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.4777Moderately InformativeInherited
Fly Anatomy (FA)tract5.118e-05InformativeDirect
Fly Anatomy (FA)digestive system0.0005528InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.0008877InformativeDirect
Fly Anatomy (FA)primordium0.02569InformativeInherited
Fly Anatomy (FA)ganglion0.06237InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.1437InformativeInherited
Fly Anatomy (FA)hindgut2.925e-06Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath5.484e-06Highly InformativeDirect
Fly Anatomy (FA)commissure7.948e-06Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system1.822e-05Highly InformativeDirect
Fly Anatomy (FA)midgut primordium9.222e-05Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.0001335Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0005325Highly InformativeDirect
Fly Anatomy (FA)CNS glial cell0.0008151Highly InformativeDirect

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.0122InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0.09054Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.877InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor6.378e-05Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.006416Highly InformativeInherited
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.01251Highly InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)vitamins0.003465Least InformativeInherited
Drugbank ATC_code (DB)blood and blood forming organs0.05584Least InformativeInherited
Drugbank ATC_code (DB)nervous system2.626e-07Moderately InformativeDirect
Drugbank ATC_code (DB)antiinfectives for systemic use1.492e-06Moderately InformativeDirect
Drugbank ATC_code (DB)genito urinary system and sex hormones2.27e-06Moderately InformativeDirect
Drugbank ATC_code (DB)dermatologicals4.277e-06Moderately InformativeDirect
Drugbank ATC_code (DB)respiratory system4.543e-06Moderately InformativeDirect
Drugbank ATC_code (DB)antineoplastic agents0.1288Moderately InformativeInherited
Drugbank ATC_code (DB)other plain vitamin preparations1Moderately InformativeInherited
Drugbank ATC_code (DB)antithrombotic agents1Moderately InformativeInherited
Drugbank ATC_code (DB)other ophthalmologicals1Moderately InformativeInherited
Drugbank ATC_code (DB)antiprotozoals1.993e-08InformativeDirect
Drugbank ATC_code (DB)drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)2.283e-07InformativeDirect
Drugbank ATC_code (DB)norfloxacin1.328e-05InformativeDirect
Drugbank ATC_code (DB)otologicals1.385e-05InformativeDirect
Drugbank ATC_code (DB)antiinflammatory and antirheumatic products, non-steroids1.673e-05InformativeDirect
Drugbank ATC_code (DB)platelet aggregation inhibitors excl. heparin2.17e-05InformativeDirect
Drugbank ATC_code (DB)sex hormones and modulators of the genital system4.798e-05InformativeDirect
Drugbank ATC_code (DB)antimycobacterials5.267e-05InformativeDirect
Drugbank ATC_code (DB)endocrine therapy0.0001352InformativeDirect
Drugbank ATC_code (DB)antiemetics and antinauseants0.0002013InformativeDirect
Drugbank ATC_code (DB)selective serotonin (5ht1) agonists0.0002589InformativeDirect
Drugbank ATC_code (DB)diagnostic agents0.008367InformativeInherited
Drugbank ATC_code (DB)antiinfectives0.01434InformativeInherited
Drugbank ATC_code (DB)antibiotics and chemotherapeutics for dermatological use0.01844InformativeInherited
Drugbank ATC_code (DB)anti-parkinson drugs0.2068InformativeInherited
Drugbank ATC_code (DB)urologicals0.2602InformativeInherited
Drugbank ATC_code (DB)beta blocking agents, non-selective0.2722InformativeInherited
Drugbank ATC_code (DB)antihypertensives0.2732InformativeInherited
Drugbank ATC_code (DB)other systemic drugs for obstructive airway diseases0.3975InformativeInherited
Drugbank ATC_code (DB)drugs for functional gastrointestinal disorders0.7466InformativeInherited
Drugbank ATC_code (DB)other dermatologicals1InformativeInherited
Drugbank ATC_code (DB)direct acting antivirals1InformativeInherited
Drugbank ATC_code (DB)natural opium alkaloids1InformativeInherited
Drugbank ATC_code (DB)quinine1.276e-13Highly InformativeDirect
Drugbank ATC_code (DB)azelastine1.071e-10Highly InformativeDirect
Drugbank ATC_code (DB)azelastine1.071e-10Highly InformativeDirect
Drugbank ATC_code (DB)azelastine1.071e-10Highly InformativeDirect
Drugbank ATC_code (DB)triazole derivatives5.731e-10Highly InformativeDirect
Drugbank ATC_code (DB)propranolol8.371e-09Highly InformativeDirect
Drugbank ATC_code (DB)other anti-acne preparations for topical use1.272e-08Highly InformativeDirect
Drugbank ATC_code (DB)other analgesics and antipyretics2.086e-08Highly InformativeDirect
Drugbank ATC_code (DB)antihistamines for topical use2.213e-08Highly InformativeDirect
Drugbank ATC_code (DB)rifampicin2.213e-08Highly InformativeDirect
Drugbank ATC_code (DB)diphenhydramine2.213e-08Highly InformativeDirect
Drugbank ATC_code (DB)anthracyclines and related substances5.03e-08Highly InformativeDirect
Drugbank ATC_code (DB)thalidomide5.03e-08Highly InformativeDirect
Drugbank ATC_code (DB)dapsone5.26e-08Highly InformativeDirect
Drugbank ATC_code (DB)medroxyprogesterone1.022e-07Highly InformativeDirect
Drugbank ATC_code (DB)pregnen (4) derivatives1.022e-07Highly InformativeDirect
Drugbank ATC_code (DB)medroxyprogesterone1.022e-07Highly InformativeDirect
Drugbank ATC_code (DB)phenazone1.022e-07Highly InformativeDirect
Drugbank ATC_code (DB)other drugs for disorders of the musculo-skeletal system2.327e-07Highly InformativeDirect
Drugbank ATC_code (DB)vitamin d and analogues2.662e-07Highly InformativeDirect
Drugbank ATC_code (DB)fluvastatin2.662e-07Highly InformativeDirect
Drugbank ATC_code (DB)3-oxoandrosten (4) derivatives6.089e-07Highly InformativeDirect
Drugbank ATC_code (DB)antiinfectives6.089e-07Highly InformativeDirect
Drugbank ATC_code (DB)nicotinic acid1.146e-06Highly InformativeDirect
Drugbank ATC_code (DB)chloramphenicol1.146e-06Highly InformativeDirect
Drugbank ATC_code (DB)chloramphenicol1.146e-06Highly InformativeDirect
Drugbank ATC_code (DB)chloramphenicol1.146e-06Highly InformativeDirect
Drugbank ATC_code (DB)telithromycin1.146e-06Highly InformativeDirect
Drugbank ATC_code (DB)ciprofloxacin1.146e-06Highly InformativeDirect
Drugbank ATC_code (DB)pimozide1.146e-06Highly InformativeDirect
Drugbank ATC_code (DB)aripiprazole1.146e-06Highly InformativeDirect
Drugbank ATC_code (DB)drugs used in nicotine dependence1.146e-06Highly InformativeDirect
Drugbank ATC_code (DB)chloramphenicol1.146e-06Highly InformativeDirect
Drugbank ATC_code (DB)imidazoline receptor agonists3.157e-06Highly InformativeDirect
Drugbank ATC_code (DB)miconazole1.298e-05Highly InformativeDirect
Drugbank ATC_code (DB)imidazole derivatives1.298e-05Highly InformativeDirect
Drugbank ATC_code (DB)sitaxentan1.298e-05Highly InformativeDirect
Drugbank ATC_code (DB)finasteride1.298e-05Highly InformativeDirect
Drugbank ATC_code (DB)hydromorphone1.298e-05Highly InformativeDirect
Drugbank ATC_code (DB)metyrapone1.298e-05Highly InformativeDirect
Drugbank ATC_code (DB)other gynecologicals1.328e-05Highly InformativeDirect
Drugbank ATC_code (DB)drugs used in benign prostatic hypertrophy1.328e-05Highly InformativeDirect
Drugbank ATC_code (DB)estrogens, combinations with other drugs2.403e-05Highly InformativeDirect
Drugbank ATC_code (DB)ciclosporin2.754e-05Highly InformativeDirect
Drugbank ATC_code (DB)serotonin receptor antagonists3.571e-05Highly InformativeDirect
Drugbank ATC_code (DB)other anti-parathyroid agents3.571e-05Highly InformativeDirect
Drugbank ATC_code (DB)vincristine3.571e-05Highly InformativeDirect
Drugbank ATC_code (DB)theophylline3.571e-05Highly InformativeDirect
Drugbank ATC_code (DB)aminophylline3.571e-05Highly InformativeDirect
Drugbank ATC_code (DB)nicotinamide4.046e-05Highly InformativeDirect
Drugbank ATC_code (DB)trimethoprim and derivatives7.889e-05Highly InformativeDirect
Drugbank ATC_code (DB)alkylating agents0.0001039Highly InformativeDirect
Drugbank ATC_code (DB)calcium channel blockers0.0001205Highly InformativeDirect
Drugbank ATC_code (DB)protease inhibitors0.0001301Highly InformativeDirect
Drugbank ATC_code (DB)antiinflammatory preparations, non-steroids for topical use0.0002589Highly InformativeDirect
Drugbank ATC_code (DB)peripheral vasodilators0.0003018Highly InformativeDirect
Drugbank ATC_code (DB)antivertigo preparations0.0003416Highly InformativeDirect
Drugbank ATC_code (DB)amphenicols0.0003889Highly InformativeDirect
Drugbank ATC_code (DB)dopaminergic agents0.0004049Highly InformativeDirect
Drugbank ATC_code (DB)muscle relaxants, centrally acting agents0.0005885Highly InformativeDirect
Drugbank ATC_code (DB)hypnotics and sedatives0.0007563Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processFatty acid metabolism1InformativeInherited
Biological processLipid biosynthesis1InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processAntibiotic biosynthesis4.53e-06Highly InformativeDirect
Biological processGrowth regulation6.27e-06Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMicrosome0Highly InformativeDirect
Coding sequence diversityPolymorphism2.755e-06Moderately InformativeDirect
DiseaseDisease mutation6.957e-05Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide2.83e-08Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionLipid-binding0.2169InformativeInherited
Molecular functionSteroid-binding3.278e-09Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.6523Least InformativeInherited
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis2.871e-11Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism1.077e-05Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)alkaloid metabolism0InformativeDirect
UniPathway (UP)terpene metabolism0InformativeDirect
UniPathway (UP)hormone metabolism0InformativeDirect
UniPathway (UP)alcohol biosynthesis0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)toxin biosynthesis4.33e-13InformativeDirect
UniPathway (UP)antibiotic biosynthesis2.835e-10InformativeDirect
UniPathway (UP)pigment biosynthesis0.0004671InformativeDirect
UniPathway (UP)flavonoid metabolism0.9204InformativeInherited
UniPathway (UP)mycotoxin biosynthesis5.809e-14Highly InformativeDirect
UniPathway (UP)oxylipin biosynthesis1.044e-11Highly InformativeDirect
UniPathway (UP)anthocyanin biosynthesis1.505e-10Highly InformativeDirect
UniPathway (UP)erythromycin biosynthesis0.0001874Highly InformativeDirect
UniPathway (UP)plant hormone biosynthesis0.6889Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001128 SSF48264 Protein matches
Abstract

More information about these proteins can be found at Protein of the Month: Cytochrome P450.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the Cytochrome P450 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]