SUPERFAMILY 1.75 HMM library and genome assignments server


Cytochrome P450 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Families:   Cytochrome P450 [ 48265] (22)


Superfamily statistics
Genomes (1,295) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 55,368 0 76
Proteins 54,135 0 76


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process3.627e-120Least InformativeDirect
Biological Process (BP)single-organism metabolic process1.334e-110Least InformativeDirect
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus0.15161Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.10331Least InformativeInherited
Biological Process (BP)regulation of cellular process0.93671Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.00170Least InformativeInherited
Biological Process (BP)lipid biosynthetic process7.072e-120Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process5.615e-110Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process2.101e-060Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus2.994e-075.782e-09Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process1.458e-060Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process7.673e-110Moderately InformativeDirect
Biological Process (BP)regulation of developmental process2.026e-051Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.14050.2244Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.021241Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0021311Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus6.234e-070.6898Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0090821Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0015281Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.015411Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process4.251e-051Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.00035851Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process1.384e-051Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.029851Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus6.128e-051Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.00028681Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.73411Moderately InformativeInherited
Biological Process (BP)homeostatic process0.45251Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process5.298e-100InformativeDirect
Biological Process (BP)regulation of hormone levels2.121e-060InformativeDirect
Biological Process (BP)regulation of response to external stimulus3.187e-100.0006134InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process2.12e-110.0001635InformativeDirect
Biological Process (BP)regulation of apoptotic process2.22e-061InformativeInherited
Biological Process (BP)response to cytokine stimulus6.77e-070.04387InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.97171InformativeInherited
Biological Process (BP)response to lipid0.95320.03927InformativeInherited
Biological Process (BP)response to organic cyclic compound0.76484.132e-06InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0029328.081e-11InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis3.344e-050.6511InformativeInherited
Biological Process (BP)positive regulation of developmental process1.502e-100.3363InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process4.177e-071InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process6.223e-101InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.050746.813e-14InformativeInherited
Biological Process (BP)positive regulation of signal transduction1.246e-071InformativeInherited
Biological Process (BP)regulation of response to stress1.691e-070.3378InformativeInherited
Biological Process (BP)negative regulation of response to stimulus3.574e-080.6276InformativeInherited
Biological Process (BP)secondary metabolic process0.013051.922e-15InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.056820.1575InformativeInherited
Biological Process (BP)glycosyl compound biosynthetic process0.19390.01408InformativeInherited
Biological Process (BP)vitamin metabolic process0.31749.144e-12InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.2151.718e-09InformativeInherited
Biological Process (BP)lipid catabolic process0.01141.9e-06InformativeInherited
Biological Process (BP)response to hypoxia1.874e-141.022e-05Highly InformativeDirect
Biological Process (BP)icosanoid metabolic process1.007e-120Highly InformativeDirect
Biological Process (BP)steroid biosynthetic process1.27e-100Highly InformativeDirect
Biological Process (BP)steroid catabolic process2.494e-076.832e-13Highly InformativeDirect
Biological Process (BP)xenobiotic metabolic process4.658e-060Highly InformativeDirect
Biological Process (BP)glycoside metabolic process2.621e-054.412e-07Highly InformativeDirect
Biological Process (BP)antibiotic biosynthetic process6.712e-068.393e-05Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus02.301e-07Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid metabolic process1.619e-090Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process0.00030390Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process9.238e-070Highly InformativeDirect
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity01.111e-12Highly InformativeDirect
Biological Process (BP)regulation of nitric oxide biosynthetic process03.722e-15Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis01.393e-07Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.00014811.024e-05Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process7.084e-141.422e-14Highly InformativeDirect
Biological Process (BP)cellular response to alcohol0.14070.04773Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus0.07570.3183Highly InformativeInherited
Biological Process (BP)carbohydrate homeostasis0.010690.2469Highly InformativeInherited
Biological Process (BP)regulation of cellular ketone metabolic process0.0091910.07161Highly InformativeInherited
Biological Process (BP)alcohol biosynthetic process0.10911.318e-07Highly InformativeInherited
Biological Process (BP)polyol metabolic process11Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.1750.0006147Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)isomerase activity8.264e-080.005878Moderately InformativeInherited
Molecular Function (MF)intramolecular oxidoreductase activity1.32e-152.09e-13InformativeDirect
Molecular Function (MF)tetrapyrrole binding2.849e-090InformativeDirect
Molecular Function (MF)monooxygenase activity00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge1.32e-150Highly InformativeDirect
Molecular Function (MF)heme binding1.55e-090Highly InformativeDirect
Cellular Component (CC)membrane0.74061Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.86711Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum7.9e-130Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.25831Moderately InformativeInherited
Cellular Component (CC)membrane raft03.024e-05Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) lipid biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 5.782e-09 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6898 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.7295 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.2244 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.3029 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.3821 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.05126 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9522 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) fatty acid metabolic process 8.081e-11 Informative Direct
Biological Process (BP) isoprenoid metabolic process 1.718e-09 Informative Direct
Biological Process (BP) vitamin metabolic process 9.144e-12 Informative Direct
Biological Process (BP) blood circulation 0.000791 Informative Direct
Biological Process (BP) regulation of hormone levels 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 4.132e-06 Informative Direct
Biological Process (BP) lipid catabolic process 1.9e-06 Informative Direct
Biological Process (BP) secondary metabolic process 1.922e-15 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0006134 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0001635 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 6.813e-14 Informative Direct
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.04387 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to lipid 0.03927 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) regulation of response to stress 0.3378 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.5177 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.6511 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3363 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.008222 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.3868 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.6276 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.0878 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.1575 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.01408 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.3705 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6419 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.02636 Informative Inherited
Biological Process (BP) response to hypoxia 1.022e-05 Highly Informative Direct
Biological Process (BP) tryptophan metabolic process 4.846e-06 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) steroid catabolic process 6.832e-13 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 1.327e-05 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 3.677e-05 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0 Highly Informative Direct
Biological Process (BP) response to toxic substance 2.96e-05 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 8.275e-07 Highly Informative Direct
Biological Process (BP) sterol metabolic process 2.974e-06 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 4.412e-07 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 8.393e-05 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 2.301e-07 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 1.032e-12 Highly Informative Direct
Biological Process (BP) quinone cofactor metabolic process 5.44e-07 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 0.0003934 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 2.893e-05 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 1.111e-12 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0006147 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 3.722e-15 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 1.393e-07 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 1.318e-07 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 1.024e-05 Highly Informative Direct
Biological Process (BP) regulation of coagulation 3.715e-05 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.0003813 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 2.286e-05 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 1.422e-14 Highly Informative Direct
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) cellular response to alcohol 0.04773 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.3183 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.2469 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.07161 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.1824 Highly Informative Inherited
Biological Process (BP) response to drug 0.01146 Highly Informative Inherited
Biological Process (BP) quinone metabolic process 1 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 1 Highly Informative Inherited
Biological Process (BP) retinoid metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6183 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 0.1622 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.9052 Highly Informative Inherited
Biological Process (BP) external encapsulating structure organization 0.04108 Highly Informative Inherited
Biological Process (BP) lipid modification 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.5028 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.005878 Moderately Informative Inherited
Molecular Function (MF) intramolecular oxidoreductase activity 2.09e-13 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) drug binding 0.0009064 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 2.047e-07 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.01021 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) membrane raft 3.024e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7611Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.02235InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)With a reduced iron-sulfur protein as one donor, a1.495e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)syndrome0.008466Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.02377Moderately InformativeInherited
Disease Ontology (DO)physical disorder0.039InformativeInherited
Disease Ontology (DO)hypospadias3.85e-05Highly InformativeDirect
Disease Ontology (DO)hyperandrogenism0.0002276Highly InformativeDirect
Disease Ontology (DO)thoracic disease0.0004217Highly InformativeDirect
Disease Ontology (DO)polycystic ovary syndrome0.0008456Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.06953InformativeInherited
Phenotypic Abnormality (PA)Adrenogenital syndrome8.435e-06Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.3361Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8385Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.01077Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1709Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1998Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.3297Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.3416Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.588Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure1.339e-05InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.08284InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.4353InformativeInherited
Mammalian Phenotype (MP)abnormal xenobiotic pharmacokinetics2.648e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0003825Highly InformativeDirect
Mammalian Phenotype (MP)abnormal uterus morphology0.006831Highly InformativeInherited
Mammalian Phenotype (MP)abnormal adrenal gland morphology0.009704Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating aldosterone level0.7058Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.2164Least InformativeInherited
Worm Phenotype (WP)metal response variant0.0001096InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.04624Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1283Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2685Least InformativeInherited
Fly Anatomy (FA)organ system0.2705Least InformativeInherited
Fly Anatomy (FA)cell0.5919Least InformativeInherited
Fly Anatomy (FA)larva0.5975Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.00495Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01309Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1354Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.2108Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.3862Moderately InformativeInherited
Fly Anatomy (FA)head0.4367Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.5256Moderately InformativeInherited
Fly Anatomy (FA)midgut2.231e-05InformativeDirect
Fly Anatomy (FA)alimentary canal0.0001721InformativeDirect
Fly Anatomy (FA)tract neuropil0.0002048InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.0006658InformativeDirect
Fly Anatomy (FA)neuron projection bundle0.00102InformativeInherited
Fly Anatomy (FA)embryonic/larval digestive system0.00157InformativeInherited
Fly Anatomy (FA)primordium0.02491InformativeInherited
Fly Anatomy (FA)embryonic/larval nervous system0.05732InformativeInherited
Fly Anatomy (FA)embryonic/larval cuticle0.1637InformativeInherited
Fly Anatomy (FA)hindgut2.703e-06Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath5.369e-06Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system1.207e-05Highly InformativeDirect
Fly Anatomy (FA)midgut primordium9.127e-05Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.0001198Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0004985Highly InformativeDirect
Fly Anatomy (FA)CNS glial cell0.0007805Highly InformativeDirect
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0009196Highly InformativeDirect
Fly Anatomy (FA)ventral nerve cord0.002566Highly InformativeInherited

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.01248InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0.1213Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.907InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases4.81e-16Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor8.018e-05Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.002577Highly InformativeInherited
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.01607Highly InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processFatty acid metabolism1InformativeInherited
Biological processLipid biosynthesis1InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processGrowth regulation7.459e-11Highly InformativeDirect
Biological processAntibiotic biosynthesis3.184e-09Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMicrosome0Highly InformativeDirect
Coding sequence diversityPolymorphism4.155e-06Moderately InformativeDirect
DiseaseDisease mutation0.0001046Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide4.762e-07Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionLipid-binding0.359InformativeInherited
Molecular functionSteroid-binding4.694e-09Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.7204Least InformativeInherited
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis1.995e-10Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism2.059e-05Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)antibiotic biosynthesis0InformativeDirect
UniPathway (UP)alkaloid metabolism0InformativeDirect
UniPathway (UP)terpene metabolism0InformativeDirect
UniPathway (UP)alcohol biosynthesis0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)toxin biosynthesis4.523e-16InformativeDirect
UniPathway (UP)pigment biosynthesis0.0008597InformativeDirect
UniPathway (UP)hormone biosynthesis0.004199InformativeInherited
UniPathway (UP)plant hormone metabolism0.495InformativeInherited
UniPathway (UP)flavonoid metabolism0.996InformativeInherited
UniPathway (UP)mycotoxin biosynthesis0Highly InformativeDirect
UniPathway (UP)oxylipin biosynthesis1.078e-11Highly InformativeDirect
UniPathway (UP)anthocyanin biosynthesis6.115e-10Highly InformativeDirect
UniPathway (UP)erythromycin biosynthesis0.0007681Highly InformativeDirect
UniPathway (UP)steroid hormone biosynthesis0.1598Highly InformativeInherited
UniPathway (UP)monoterpene metabolism0.5951Highly InformativeInherited
UniPathway (UP)plant hormone biosynthesis0.8315Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001128 SSF48264 Protein matches
Abstract

More information about these proteins can be found at Protein of the Month: Cytochrome P450.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the Cytochrome P450 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]