SUPERFAMILY 1.75 HMM library and genome assignments server

Terpenoid cyclases/Protein prenyltransferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha/alpha toroid [ 48207] (6)
Superfamily:   Terpenoid cyclases/Protein prenyltransferases [ 48239] (4)
Families:   Terpenoid cyclase N-terminal domain [ 48240] (2)
  Terpene synthases [ 48243] (2)
  Protein prenyltransferases [ 48246] (2)
  Complement components [ 48251] (2)


Superfamily statistics
Genomes (1,689) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,911 21,485 34
Proteins 9,580 18,690 29


Functional annotation
General category Metabolism
Detailed category Secondary metabolism

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00026671Least InformativeInherited
Biological Process (BP)protein metabolic process01Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.00000001651Least InformativeInherited
Biological Process (BP)response to stimulus0.10950.8786Least InformativeInherited
Biological Process (BP)single-organism metabolic process10Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.071540.9529Least InformativeInherited
Biological Process (BP)cellular protein modification process00.000006449Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization0.090450.9378Moderately InformativeInherited
Biological Process (BP)regulation of localization0.34040.2451Moderately InformativeInherited
Biological Process (BP)immune system process0.076440.2532Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.050840.0009837Moderately InformativeInherited
Biological Process (BP)regulation of immune effector process0.000085680.0000003513InformativeDirect
Biological Process (BP)regulation of response to wounding0.00020980.0000000009765InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport0.0042510.0008243InformativeInherited
Biological Process (BP)positive regulation of transport0.037460.00007433InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.033680.09568InformativeInherited
Biological Process (BP)immune response0.028170.0006442InformativeInherited
Biological Process (BP)regulation of immune response0.25980.00001903InformativeInherited
Biological Process (BP)immune effector process0.0010490.0000001147InformativeInherited
Biological Process (BP)regulation of defense response0.001380.0006746InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.021460.000001897InformativeInherited
Biological Process (BP)positive regulation of immune system process0.082760.00001261InformativeInherited
Biological Process (BP)regulation of acute inflammatory response0.00000022570Highly InformativeDirect
Biological Process (BP)humoral immune response0.00024450.0000000000004067Highly InformativeDirect
Biological Process (BP)regulation of endocytosis0.00018280.00002191Highly InformativeDirect
Biological Process (BP)protein activation cascade0.001660.00000000000003411Highly InformativeInherited
Molecular Function (MF)binding0.0000000037241Least InformativeInherited
Molecular Function (MF)transferase activity01Least InformativeInherited
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)zinc ion binding00.00002658InformativeDirect
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups00InformativeDirect
Molecular Function (MF)enzyme binding0.00000024820.008662InformativeInherited
Molecular Function (MF)prenyltransferase activity00Highly InformativeDirect
Molecular Function (MF)Ras GTPase binding10.00000001373Highly InformativeInherited
Cellular Component (CC)protein complex00.1186Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.51081Least InformativeInherited
Cellular Component (CC)transferase complex00Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.000001102 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.9529 Least Informative Inherited
Biological Process (BP) response to stimulus 0.8786 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.000006449 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0000002508 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.000009746 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0009837 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.187 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001237 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.4586 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7238 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.9378 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.3213 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.004975 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.75 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2451 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1051 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.04566 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.005347 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2532 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.009047 Moderately Informative Inherited
Biological Process (BP) response to acid chemical 0.00001959 Informative Direct
Biological Process (BP) immune effector process 0.0000001147 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.00001261 Informative Direct
Biological Process (BP) regulation of immune effector process 0.0000003513 Informative Direct
Biological Process (BP) alcohol metabolic process 0.00000000001764 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0 Informative Direct
Biological Process (BP) immune response 0.0006442 Informative Direct
Biological Process (BP) regulation of defense response 0.0006746 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000001897 Informative Direct
Biological Process (BP) regulation of immune response 0.00001903 Informative Direct
Biological Process (BP) positive regulation of transport 0.00007433 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.0002506 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0008243 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00002726 Informative Direct
Biological Process (BP) regulation of response to wounding 0.0000000009765 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.001565 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.02814 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.09568 Informative Inherited
Biological Process (BP) lipid catabolic process 0.1683 Informative Inherited
Biological Process (BP) negative regulation of protein processing 0.8608 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.02886 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.5103 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1357 Informative Inherited
Biological Process (BP) regulation of acute inflammatory response 0 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 0.000000007353 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.00000009024 Highly Informative Direct
Biological Process (BP) phagocytosis 0.00002038 Highly Informative Direct
Biological Process (BP) humoral immune response 0.0000000000004067 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.0000004373 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 0.000000007705 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.000000019 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 0.00002191 Highly Informative Direct
Biological Process (BP) protein activation cascade 0.00000000000003411 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.004302 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.00000006769 Informative Direct
Molecular Function (MF) zinc ion binding 0.00002658 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.000000001933 Informative Direct
Molecular Function (MF) receptor binding 0.04532 Informative Inherited
Molecular Function (MF) enzyme binding 0.008662 Informative Inherited
Molecular Function (MF) prenyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) carbon-oxygen lyase activity, acting on phosphates 0 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.00000001373 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.1186 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.3157 Moderately Informative Inherited
Cellular Component (CC) plastid 0.00006014 Informative Direct
Cellular Component (CC) extracellular space 0.005732 Informative Inherited
Cellular Component (CC) chloroplast stroma 0.0000001365 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring other groups0InformativeDirect
Enzyme Commission (EC)Acting on phosphates0InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Protein geranylgeranyltransferase type II0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)mouth disease0.0007033Moderately InformativeDirect
Disease Ontology (DO)skin disease0.01649Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.01653Moderately InformativeInherited
Disease Ontology (DO)periodontitis0.0002018InformativeDirect
Disease Ontology (DO)psoriasis0.0007195InformativeDirect
Disease Ontology (DO)proteinuria0.0000217Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.002084Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.289Least InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.001118Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.004894Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.1786Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.001671InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.02823InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.04854InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.1155InformativeInherited
Mammalian Phenotype (MP)abnormal pregnancy0.0005355Highly InformativeDirect
Mammalian Phenotype (MP)abnormal trophoblast layer morphology0.0005491Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced morbidity/mortality0.0005601Highly InformativeDirect
Mammalian Phenotype (MP)abnormal placenta labyrinth morphology0.0007405Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.004687Least InformativeInherited
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.00004012Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0.03375Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.865Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.4626Moderately InformativeInherited
Xenopus ANatomical entity (XAN)midgut0.000001234Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindgut0.000004555Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0002736Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)filament0.00017Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular transferases (mutases)0.00000000000003473InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Diphosphoric monoester hydrolases0.0000000008436Highly InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antiinfectives for systemic use0.00002366Least InformativeDirect
Drugbank ATC_code (DB)immunoglobulins, normal human0.000000001435InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.01677Moderately InformativeInherited
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processLipid biosynthesis0.4958InformativeInherited
Biological processComplement pathway0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processComplement alternate pathway0.0000000001395Highly InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentSecreted0.00000002406Moderately InformativeDirect
Cellular componentChloroplast0InformativeDirect
DomainRepeat0.0003547Least InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionPotassium0.00008331InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationToxin0.461InformativeInherited
Post-translational modificationGlycoprotein0.000117Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0.00000000000002255Moderately InformativeDirect
Post-translational modificationSulfation0.000001163InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.2851Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)terpene metabolism0InformativeDirect
UniPathway (UP)plant hormone metabolism0.00000000006442InformativeDirect
UniPathway (UP)alkaloid metabolism0.00002094InformativeDirect
UniPathway (UP)plant hormone biosynthesis0.000000000002915Highly InformativeDirect
UniPathway (UP)monoterpene metabolism0.08583Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008930 SSF48239 Protein matches
Abstract

Protein prenyltransferases catalyze the transfer of the carbon moiety of C15 farnesyl pyrophosphate or geranylgeranyl pyrophosphate synthase to a conserved cysteine residue in a CaaX motif of protein and peptide substrates. The addition of a farnesyl group is required to anchor proteins to the cell membrane. In the 3D structure of a mammalian Ras farnesyltransferases (Ftase), both subunits are largely composed of alpha-helices. The alpha-2 to alpha-15 helices in the alpha subunit fold into a novel helical hairpin structure, resulting in a crescent-shape domain that envelopes part of the subunit. The 12 helices of the beta-subunit form an alpha-alpha barrel. Six additional helices connect the inner core of helices and form the outside of the helical barrel. A deep cleft surrounded by hydrophobic amino acids in the centre of the barrel is proposed as the FPP-binding pocket. A single Zn2+ ion is located at the junction between the hydrophilic surface groove near the subunit interface

Terpenoid cyclases such as squalene cyclase, pentalenene synthase, 5-epi-aristolochene synthase, and trichodiene synthase are responsible for the synthesis of cholesterol, a hydrocarbon precursor of the pentalenolactone family of antibiotics, a precursor of the antifungal phytoalexin capsidiol, and the precursor of antibiotics and mycotoxins, respectively. In the structures of these three enzymes, the similar structural feature referred to as 'terpenoid synthase fold' with 10-12 mostly antiparallel alpha-helices is found, as also observed in protein prenyltransferases. The high structural similarity provides support for the hypothesis that the three families of prenyltransferases have related evolution despite their low sequence similarity [PubMed12135472].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Terpenoid cyclases/Protein prenyltransferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Terpenoid cyclases/Protein prenyltransferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]