SUPERFAMILY 1.75 HMM library and genome assignments server


Seven-hairpin glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha/alpha toroid [ 48207] (6)
Superfamily:   Seven-hairpin glycosidases [ 48225]
Families:   Class I alpha-1;2-mannosidase, catalytic domain [ 48226]


Superfamily statistics
Genomes (468) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,037 3,505 9
Proteins 2,988 3,476 9


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.00031842.18e-12Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process3.295e-090Least InformativeDirect
Biological Process (BP)cellular catabolic process0.00046726.559e-12Moderately InformativeDirect
Biological Process (BP)carbohydrate metabolic process0.035291.538e-07Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.0037285.363e-09Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.065333.98e-08Moderately InformativeInherited
Biological Process (BP)protein catabolic process7.185e-060InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process3.426e-060InformativeDirect
Biological Process (BP)proteolysis0.022038.92e-09InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process8.235e-090Highly InformativeDirect
Biological Process (BP)proteasomal protein catabolic process0.23511.981e-05Highly InformativeInherited
Molecular Function (MF)hydrolase activity4.444e-080Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Cellular Component (CC)intracellular organelle part0.01360.0003303Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.11660.001532Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.11212.19e-06Least InformativeInherited
Cellular Component (CC)membrane0.025140.005674Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum3.411e-050Moderately InformativeDirect
Cellular Component (CC)endomembrane system1.55e-050Moderately InformativeDirect
Cellular Component (CC)organelle membrane0.0003432.045e-11Moderately InformativeDirect
Cellular Component (CC)endoplasmic reticulum membrane7.155e-072.935e-06InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 2.18e-12 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.7918 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1.538e-07 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 6.559e-12 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 3.98e-08 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 5.363e-09 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.04114 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1018 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.08084 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.4385 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.4262 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.05225 Moderately Informative Inherited
Biological Process (BP) proteolysis 8.92e-09 Informative Direct
Biological Process (BP) hexose metabolic process 0.0001656 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.03998 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) protein glycosylation 0 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 6.998e-10 Highly Informative Direct
Biological Process (BP) aging 0.0001122 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 1.981e-05 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 2.314e-08 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 6.746e-10 Highly Informative Direct
Biological Process (BP) post-translational protein modification 1.111e-08 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0.002132 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Cellular Component (CC) cytoplasmic part 2.19e-06 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0003303 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.001532 Least Informative Inherited
Cellular Component (CC) membrane 0.005674 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 2.045e-11 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.03335 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 2.935e-06 Informative Direct
Cellular Component (CC) Golgi apparatus 1.549e-07 Informative Direct
Cellular Component (CC) integral to membrane 0.0003881 Informative Direct
Cellular Component (CC) Golgi membrane 1.867e-05 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 3.455e-09 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)fruit6.294e-05InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism1.7e-08Moderately InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Cellular componentMembrane1.903e-06Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus2.169e-13Moderately InformativeDirect
Cellular componentCytoplasmic vesicle3.848e-11Moderately InformativeDirect
DomainTransmembrane0.0005257Least InformativeDirect
DomainSignal-anchor0InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycoprotein3.051e-14Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein glycosylation0InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001382 SSF48225 Protein matches
Abstract

Glycoside hydrolase family 47 comprises enzymes with only one known activity; alpha-mannosidase .

Alpha-mannosidase is involved in the maturation of Asn-linked oligo-saccharides [PubMed8144580]. The enzyme hydrolyses terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide man(9)(glcnac)(2) in a calcium-dependent manner. The mannose residues are trimmed away to produce, first, man(8)glcnac(2), then a man(5)(glcnac)(2) structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Seven-hairpin glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Seven-hairpin glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]