SUPERFAMILY 1.75 HMM library and genome assignments server

Seven-hairpin glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha/alpha toroid [ 48207] (6)
Superfamily:   Seven-hairpin glycosidases [ 48225]
Families:   Class I alpha-1;2-mannosidase, catalytic domain [ 48226]


Superfamily statistics
Genomes (480) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,143 3,505 9
Proteins 3,093 3,476 9


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.00028040.000000000001988Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.0000000040220Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.66940.2029Least InformativeInherited
Biological Process (BP)cellular catabolic process0.00045140.000000000005792Moderately InformativeDirect
Biological Process (BP)carbohydrate metabolic process0.034380.0000001389Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.0036060.000000005102Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.074960.00000007266Moderately InformativeInherited
Biological Process (BP)protein catabolic process0.0000069680InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.0000031680InformativeDirect
Biological Process (BP)proteolysis0.021150.00000001138InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process0.0000000090090Highly InformativeDirect
Biological Process (BP)proteasomal protein catabolic process0.25510.00002903Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.000000056760Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds6.814e-160InformativeDirect
Cellular Component (CC)intracellular organelle part0.014490.000005124Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.11970.000001613Least InformativeInherited
Cellular Component (CC)membrane0.031660.006374Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.11460.0005606Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.00003880Moderately InformativeDirect
Cellular Component (CC)bounding membrane of organelle0.00004830.00000000000001464Moderately InformativeDirect
Cellular Component (CC)membrane region0.000016150.00006955Moderately InformativeDirect
Cellular Component (CC)endoplasmic reticulum membrane0.00000080430.000002522InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.000000000001988 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.7718 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.2029 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0000001389 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000000000005792 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00000007266 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000005102 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.09079 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.04116 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1036 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.4194 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.04908 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.00000001138 Informative Direct
Biological Process (BP) hexose metabolic process 0.00006838 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0433 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) protein glycosylation 0 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.0000000006021 Highly Informative Direct
Biological Process (BP) aging 0.0001147 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0.0006867 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.00002903 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00000002772 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.0000000005611 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.00000001143 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0005606 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000001613 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000005124 Least Informative Direct
Cellular Component (CC) membrane 0.006374 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.00000000000001464 Moderately Informative Direct
Cellular Component (CC) membrane region 0.00006955 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.02901 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.000002522 Informative Direct
Cellular Component (CC) Golgi apparatus 0.000001031 Informative Direct
Cellular Component (CC) integral component of membrane 0.01556 Informative Inherited
Cellular Component (CC) integral component of organelle membrane 0.000000005565 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant ANatomical entity (PAN)fruit0.00006294InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0.00000001717Moderately InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Cellular componentMembrane0.000001999Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000000000002244Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00000000003996Moderately InformativeDirect
DomainTransmembrane0.0005345Least InformativeDirect
DomainSignal-anchor0InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycoprotein0.00000000000002932Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein glycosylation0InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001382 SSF48225 Protein matches
Abstract

Glycoside hydrolase family 47 comprises enzymes with only one known activity; alpha-mannosidase .

Alpha-mannosidase is involved in the maturation of Asn-linked oligo-saccharides [PubMed8144580]. The enzyme hydrolyses terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide man(9)(glcnac)(2) in a calcium-dependent manner. The mannose residues are trimmed away to produce, first, man(8)glcnac(2), then a man(5)(glcnac)(2) structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Seven-hairpin glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Seven-hairpin glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]