SUPERFAMILY 1.75 HMM library and genome assignments server


Six-hairpin glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha/alpha toroid [ 48207] (6)
Superfamily:   Six-hairpin glycosidases [ 48208] (9)
Families:   Glucoamylase [ 48209]
  Cellulases catalytic domain [ 48213] (11)
  N-acylglucosamine (NAG) epimerase [ 48222] (2)
  Glycosyltransferase family 36 C-terminal domain [ 63588] (2)
  Bacterial glucoamylase C-terminal domain-like [ 81850] (2)
  Hypothetical protein YteR [ 89108]
  Glycosyl Hydrolase Family 88 [ 109953]
  CPF0428-like [ 158737] (2)
  Trehalase-like [ 158742]


Superfamily statistics
Genomes (2,667) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 23,086 0 37
Proteins 22,903 0 37


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.89771Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.9121Least InformativeInherited
Biological Process (BP)organic substance catabolic process0.056423.008e-10Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0010810Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.64921Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process7.22e-080InformativeDirect
Biological Process (BP)carbohydrate catabolic process5.532e-050InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.00040580InformativeDirect
Biological Process (BP)oligosaccharide metabolic process0.00016312.407e-12Highly InformativeDirect
Biological Process (BP)cell wall biogenesis0.00050040.000676Highly InformativeDirect
Biological Process (BP)cellular carbohydrate catabolic process5.738e-050Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.71234.668e-07Least InformativeInherited
Molecular Function (MF)isomerase activity2.229e-050.008645Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds8.288e-070InformativeDirect
Molecular Function (MF)racemase and epimerase activity6.538e-058.998e-06InformativeDirect
Molecular Function (MF)racemase and epimerase activity, acting on carbohydrates and derivatives7.677e-101.225e-08Highly InformativeDirect
Cellular Component (CC)cell projection0.28281Moderately InformativeInherited
Cellular Component (CC)brush border8.224e-061.943e-05Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 3.008e-10 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.09978 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.0001909 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) polysaccharide catabolic process 4.619e-09 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 2.068e-09 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 2.407e-12 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.000676 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0.0005963 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 4.668e-07 Least Informative Direct
Molecular Function (MF) isomerase activity 0.008645 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) racemase and epimerase activity 8.998e-06 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.004369 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.0005335 Highly Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 1.225e-08 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.9901 Highly Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) brush border 1.943e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.03177Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.486Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbohydrates and derivatives0.0001283InformativeDirect
Enzyme Commission (EC)Cellulase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.01895Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.9515Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases1.718e-07InformativeDirect
Enzyme Commission (EC)Racemases and epimerases2.182e-05InformativeDirect
Enzyme Commission (EC)Cellulase0Highly InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives7.9e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processCellulose degradation0Highly InformativeDirect
Biological processGlycogen biosynthesis8.958e-05Highly InformativeDirect
Cellular componentMembrane0.2792Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0003523Moderately InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentGPI-anchor2.043e-09InformativeDirect
Coding sequence diversityAlternative splicing0.0006079Least InformativeDirect
DiseaseGlycogen storage disease1.734e-12InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor3.238e-09InformativeDirect
Molecular functionCalmodulin-binding2.326e-16InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationPrenylation2.299e-05InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.00269Moderately InformativeInherited
UniPathway (UP)carbohydrate degradation0.2633Moderately InformativeInherited
UniPathway (UP)glycan degradation1.617e-07InformativeDirect
UniPathway (UP)amino-sugar metabolism9.6e-07InformativeDirect
UniPathway (UP)amine and polyamine degradation2.706e-06InformativeDirect
UniPathway (UP)cellulose metabolism0.0001627InformativeDirect
UniPathway (UP)bacterial cellulose biosynthesis1.342e-15Highly InformativeDirect
UniPathway (UP)trehalose metabolism4.803e-14Highly InformativeDirect
UniPathway (UP)N-acetylneuraminate degradation1.922e-07Highly InformativeDirect
UniPathway (UP)N-glycan degradation0.0003496Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008928 SSF48208 Protein matches
Abstract

The six-hairpin glycoside transferase domain contains up to seven alpha-hairpins arranged in closed circular array. Protein families that contain domains with this structure include glucoamylases, various endocellulases and exocellulases (catalytic domain), N-acyl-D-glucosamine 2-epimerases, bacterial maltose phosphorylase (central domain), and bacterial glucoamylases (C-terminal domain).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Six-hairpin glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the Six-hairpin glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]