SUPERFAMILY 1.75 HMM library and genome assignments server


Six-hairpin glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha/alpha toroid [ 48207] (6)
Superfamily:   Six-hairpin glycosidases [ 48208] (9)
Families:   Glucoamylase [ 48209]
  Cellulases catalytic domain [ 48213] (11)
  N-acylglucosamine (NAG) epimerase [ 48222] (2)
  Glycosyltransferase family 36 C-terminal domain [ 63588] (2)
  Bacterial glucoamylase C-terminal domain-like [ 81850] (2)
  Hypothetical protein YteR [ 89108]
  Glycosyl Hydrolase Family 88 [ 109953]
  CPF0428-like [ 158737] (2)
  Trehalase-like [ 158742]


Superfamily statistics
Genomes (2,673) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 23,527 82,403 37
Proteins 23,315 82,109 37


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.88471Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.91331Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.001030Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.65471Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process6.409e-080InformativeDirect
Biological Process (BP)carbohydrate catabolic process4.794e-050InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.00042810InformativeDirect
Biological Process (BP)oligosaccharide metabolic process0.00015797.004e-13Highly InformativeDirect
Biological Process (BP)cell wall biogenesis0.00075370.0009193Highly InformativeDirect
Biological Process (BP)cellular carbohydrate catabolic process4.751e-050Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.70987.277e-08Least InformativeInherited
Molecular Function (MF)isomerase activity2.388e-050.01059Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds7.835e-070InformativeDirect
Molecular Function (MF)racemase and epimerase activity6.798e-051.01e-05InformativeDirect
Molecular Function (MF)racemase and epimerase activity, acting on carbohydrates and derivatives7.676e-101.204e-08Highly InformativeDirect
Cellular Component (CC)cell projection0.28481Moderately InformativeInherited
Cellular Component (CC)brush border7.63e-061.802e-05Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.0001849 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) polysaccharide catabolic process 6.437e-09 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 2.065e-09 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 7.004e-13 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.0009193 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0.0006574 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 7.277e-08 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.01059 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) racemase and epimerase activity 1.01e-05 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.004651 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.0005526 Highly Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 1.204e-08 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.9824 Highly Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) brush border 1.802e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.03177Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.486Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbohydrates and derivatives0.0001283InformativeDirect
Enzyme Commission (EC)Cellulase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.00475Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.96Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases6.611e-09InformativeDirect
Enzyme Commission (EC)Racemases and epimerases2.36e-05InformativeDirect
Enzyme Commission (EC)Cellulase0Highly InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives8.835e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processCellulose degradation0Highly InformativeDirect
Biological processGlycogen biosynthesis9.415e-05Highly InformativeDirect
Cellular componentMembrane0.2837Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000349Moderately InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentGPI-anchor1.998e-09InformativeDirect
Coding sequence diversityAlternative splicing0.0006596Least InformativeDirect
DiseaseGlycogen storage disease1.734e-12InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor3.501e-09InformativeDirect
Molecular functionCalmodulin-binding2.325e-16InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationPrenylation2.262e-05InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism5.792e-10Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008928 SSF48208 Protein matches
Abstract

The six-hairpin glycoside transferase domain contains up to seven alpha-hairpins arranged in closed circular array. Protein families that contain domains with this structure include glucoamylases, various endocellulases and exocellulases (catalytic domain), N-acyl-D-glucosamine 2-epimerases, bacterial maltose phosphorylase (central domain), and bacterial glucoamylases (C-terminal domain).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Six-hairpin glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the Six-hairpin glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]