SUPERFAMILY 1.75 HMM library and genome assignments server

Six-hairpin glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha/alpha toroid [ 48207] (6)
Superfamily:   Six-hairpin glycosidases [ 48208] (9)
Families:   Glucoamylase [ 48209]
  Cellulases catalytic domain [ 48213] (11)
  N-acylglucosamine (NAG) epimerase [ 48222] (2)
  Glycosyltransferase family 36 C-terminal domain [ 63588] (2)
  Bacterial glucoamylase C-terminal domain-like [ 81850] (2)
  Hypothetical protein YteR [ 89108]
  Glycosyl Hydrolase Family 88 [ 109953]
  CPF0428-like [ 158737] (2)
  Trehalase-like [ 158742]


Superfamily statistics
Genomes (2,674) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 23,558 82,403 37
Proteins 23,344 82,109 37


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.88871Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)organic substance catabolic process0.058970.0000000001213Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.29370.00000001686Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0011180Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.000000064240InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.000044910InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.0004260InformativeDirect
Biological Process (BP)cell wall organization or biogenesis0.0000001190.000001477InformativeDirect
Biological Process (BP)oligosaccharide metabolic process0.00049990.000000000000001913Highly InformativeDirect
Biological Process (BP)cellular carbohydrate catabolic process0.00024390Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.70910.00000008146Least InformativeInherited
Molecular Function (MF)isomerase activity0.000024120.01062Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds0.00000081380InformativeDirect
Molecular Function (MF)racemase and epimerase activity0.000067260.0000107InformativeDirect
Molecular Function (MF)racemase and epimerase activity, acting on carbohydrates and derivatives0.00000000076220.00000001414Highly InformativeDirect
Cellular Component (CC)cell projection0.30611Moderately InformativeInherited
Cellular Component (CC)brush border0.0000074950.00001796Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.00000001686 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0000000001213 Moderately Informative Direct
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.1012 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.0001827 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.000001477 Informative Direct
Biological Process (BP) polysaccharide catabolic process 0.00000000527 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.000000001974 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0.000000000000001913 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.00000008146 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.01062 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) racemase and epimerase activity 0.0000107 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.004825 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.0005651 Highly Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 0.00000001414 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.9821 Highly Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) brush border 0.00001796 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.03177Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.486Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbohydrates and derivatives0.0001283InformativeDirect
Enzyme Commission (EC)Cellulase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.005386Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.7821Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0.000000008715InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.00002524InformativeDirect
Enzyme Commission (EC)Cellulase0Highly InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0.00000000009516Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processCellulose degradation0Highly InformativeDirect
Biological processGlycogen biosynthesis0.00009717Highly InformativeDirect
Cellular componentMembrane0.2871Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0003738Moderately InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentGPI-anchor0.000000001993InformativeDirect
DiseaseGlycogen storage disease0.000000000001717InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.000000003911InformativeDirect
Molecular functionCalmodulin-binding2.32e-16InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationPrenylation0.00002287InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.003225Moderately InformativeInherited
UniPathway (UP)carbohydrate degradation0.2911Moderately InformativeInherited
UniPathway (UP)glycan degradation0.00000002646InformativeDirect
UniPathway (UP)amino-sugar metabolism0.000001171InformativeDirect
UniPathway (UP)amine and polyamine degradation0.000003326InformativeDirect
UniPathway (UP)cellulose metabolism0.00001046InformativeDirect
UniPathway (UP)bacterial cellulose biosynthesis0.000000000000001792Highly InformativeDirect
UniPathway (UP)trehalose metabolism0.0000000000001178Highly InformativeDirect
UniPathway (UP)N-acetylneuraminate degradation0.0000002346Highly InformativeDirect
UniPathway (UP)N-glycan degradation0.0005323Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008928 SSF48208 Protein matches
Abstract

The six-hairpin glycoside transferase domain contains up to seven alpha-hairpins arranged in closed circular array. Protein families that contain domains with this structure include glucoamylases, various endocellulases and exocellulases (catalytic domain), N-acyl-D-glucosamine 2-epimerases, bacterial maltose phosphorylase (central domain), and bacterial glucoamylases (C-terminal domain).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Six-hairpin glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the Six-hairpin glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]