SUPERFAMILY 1.75 HMM library and genome assignments server


Heme-dependent peroxidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Heme-dependent peroxidases [ 48112]
Superfamily:   Heme-dependent peroxidases [ 48113] (3)
Families:   CCP-like [ 48114] (4)
  Catalase-peroxidase KatG [ 74753]
  Myeloperoxidase-like [ 48132] (2)


Superfamily statistics
Genomes (1,348) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 11,315 15,496 113
Proteins 9,965 11,978 104


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00094174.77e-07Least InformativeDirect
Biological Process (BP)developmental process1.099e-058.911e-07Least InformativeDirect
Biological Process (BP)response to stimulus2.97e-063.908e-10Least InformativeDirect
Biological Process (BP)localization0.025260.82Least InformativeInherited
Biological Process (BP)single-organism cellular process0.021880.3078Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.25231Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.36931.391e-11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.13841Least InformativeInherited
Biological Process (BP)ion transport1.021e-060.0008471Moderately InformativeDirect
Biological Process (BP)multi-organism process0.0025774.458e-08Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0065824.179e-10Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.03510.008812Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0010660.6142Moderately InformativeInherited
Biological Process (BP)cell differentiation0.90110.9022Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.00077850.005037Moderately InformativeInherited
Biological Process (BP)organ development0.21891Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus9.933e-050.109Moderately InformativeInherited
Biological Process (BP)tissue development0.00093240.3399Moderately InformativeInherited
Biological Process (BP)response to inorganic substance1.179e-051.833e-07InformativeDirect
Biological Process (BP)metal ion transport2.28e-080.0002204InformativeDirect
Biological Process (BP)response to nutrient levels2.835e-052.475e-05InformativeDirect
Biological Process (BP)nitrogen compound transport2.118e-061.653e-05InformativeDirect
Biological Process (BP)defense response0.81870.04051InformativeInherited
Biological Process (BP)anion transport0.055340.001101InformativeInherited
Biological Process (BP)epithelium development0.069390.5338InformativeInherited
Biological Process (BP)secondary metabolic process6.483e-070.001956InformativeInherited
Biological Process (BP)phenylpropanoid metabolic process9.21e-093.631e-07Highly InformativeDirect
Biological Process (BP)epidermal cell differentiation4.536e-050.0001438Highly InformativeDirect
Biological Process (BP)inorganic anion transport4.51e-051.526e-05Highly InformativeDirect
Biological Process (BP)response to fungus0.0019810.005021Highly InformativeInherited
Biological Process (BP)cellular response to starvation0.001230.02908Highly InformativeInherited
Biological Process (BP)response to osmotic stress0.012390.1356Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity4.008e-080Moderately InformativeDirect
Molecular Function (MF)peroxidase activity00Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.48171Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.034360.6132Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.019820.344Least InformativeInherited
Cellular Component (CC)external encapsulating structure00InformativeDirect
Cellular Component (CC)plastid0.00035250.0209InformativeInherited
Cellular Component (CC)cell-cell junction2.382e-060.01696InformativeInherited
Cellular Component (CC)symplast3.352e-086.898e-05Highly InformativeDirect
Cellular Component (CC)cell wall00.03765Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 2.286e-05 Least Informative Direct
Biological Process (BP) multicellular organismal process 4.77e-07 Least Informative Direct
Biological Process (BP) developmental process 8.911e-07 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1.391e-11 Least Informative Direct
Biological Process (BP) response to stimulus 3.908e-10 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 0.82 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3078 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0.0008471 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0003058 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 2.324e-09 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 4.458e-08 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 4.221e-10 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 4.179e-10 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.496 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.03182 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.01039 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.005037 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.008812 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.7209 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8648 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.01534 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6142 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9022 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.109 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3399 Moderately Informative Inherited
Biological Process (BP) system process 0.1098 Moderately Informative Inherited
Biological Process (BP) immune system process 0.002209 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 6.604e-05 Informative Direct
Biological Process (BP) fatty acid metabolic process 1.647e-12 Informative Direct
Biological Process (BP) response to oxidative stress 1.221e-08 Informative Direct
Biological Process (BP) blood circulation 3.746e-15 Informative Direct
Biological Process (BP) response to inorganic substance 1.833e-07 Informative Direct
Biological Process (BP) response to organic cyclic compound 2.141e-07 Informative Direct
Biological Process (BP) metal ion transport 0.0002204 Informative Direct
Biological Process (BP) response to nutrient levels 2.475e-05 Informative Direct
Biological Process (BP) response to cytokine stimulus 2.919e-06 Informative Direct
Biological Process (BP) nitrogen compound transport 1.653e-05 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 4.809e-10 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.4241 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.001926 Informative Inherited
Biological Process (BP) regulation of growth 0.013 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.003038 Informative Inherited
Biological Process (BP) regulation of defense response 0.03877 Informative Inherited
Biological Process (BP) anion transport 0.001101 Informative Inherited
Biological Process (BP) epithelium development 0.5338 Informative Inherited
Biological Process (BP) secondary metabolic process 0.001956 Informative Inherited
Biological Process (BP) defense response 0.04051 Informative Inherited
Biological Process (BP) immune effector process 0.1114 Informative Inherited
Biological Process (BP) transition metal ion transport 1.258e-05 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 3.631e-07 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 0.0001438 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 4.01e-11 Highly Informative Direct
Biological Process (BP) inorganic anion transport 1.526e-05 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 3.666e-06 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 2.157e-13 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.0007092 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 4.469e-10 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 4.717e-11 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0004072 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0003187 Highly Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 0 Highly Informative Direct
Biological Process (BP) response to fungus 0.005021 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.006216 Highly Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 0.02375 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.02908 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.1356 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) peroxidase activity 0 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.1074 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.6132 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.344 Least Informative Inherited
Cellular Component (CC) external encapsulating structure 0 Informative Direct
Cellular Component (CC) plastid 0.0209 Informative Inherited
Cellular Component (CC) cell-cell junction 0.01696 Informative Inherited
Cellular Component (CC) symplast 6.898e-05 Highly Informative Direct
Cellular Component (CC) cell wall 0.03765 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red1Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Peroxidases0.1679InformativeInherited
Enzyme Commission (EC)With a oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Peroxidase1.867e-15Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)lung disease0.0002305Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.0002813Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.001349Moderately InformativeInherited
Disease Ontology (DO)kidney disease0.008637Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.03353Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.06051Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.256Moderately InformativeInherited
Disease Ontology (DO)nephritis0.000552InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.000859InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.003486InformativeInherited
Disease Ontology (DO)stomach disease1.45e-05Highly InformativeDirect
Disease Ontology (DO)cystic fibrosis0.0001704Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.01904Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6355Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.001415Moderately InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.01398Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.03739Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.001729InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.02302InformativeInherited
Mammalian Phenotype (MP)increased circulating pituitary hormone level2.041e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gland physiology0.0001887Highly InformativeDirect
Mammalian Phenotype (MP)increased physiological sensitivity to xenobiotic0.0004028Highly InformativeDirect
Mammalian Phenotype (MP)decreased inflammatory response0.0005542Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.0008774Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)molt variant0.0006612Highly InformativeDirect

Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.1433Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.004184InformativeInherited
Plant ANatomical entity (PAN)root hair cell0.0003844Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on a peroxide as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen1InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)0Highly InformativeDirect
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.0123Highly InformativeInherited
Enzyme Commission (EC)Peroxidases0.1708Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.6615Moderately InformativeInherited
Biological processFatty acid metabolism1.144e-06InformativeDirect
Biological processLipid biosynthesis0.005498InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processBiological rhythms4.081e-05Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.001079Moderately InformativeInherited
Cellular componentVacuole1.192e-12InformativeDirect
Cellular componentMicrosome2.735e-14Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainEGF-like domain3.263e-05InformativeDirect
DomainSushi9.888e-05Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionPotassium3.157e-05InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationPeroxidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)hormone biosynthesis0InformativeDirect
UniPathway (UP)thyroid hormone biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR010255 SSF48113 Protein matches
Abstract Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyse a number of oxidative reactions. Most haem peroxidases follow the reaction scheme: Fe3+ + H2O2 --> [Fe4+=O]R' (Compound I) + H2O [Fe4+=O]R' + substrate --> [Fe4+=O]R (Compound II) + oxidised substrate [Fe4+=O]R + substrate --> Fe3+ + H2O + oxidised substrate

In this mechanism, the enzyme reacts with one equivalent of H2O2 to give [Fe4+=O]R' (compound I). This is a two-electron oxidation/reduction reaction where H2O2 is reduced to water and the enzyme is oxidised. One oxidising equivalent resides on iron, giving the oxyferryl [PubMed8062820] intermediate, while in many peroxidases the porphyrin (R) is oxidised to the porphyrin pi-cation radical (R'). Compound I then oxidises an organic substrate to give a substrate radical [PubMed7922023].

Haem peroxidases include two superfamilies: one found in bacteria, fungi, plants and the second found in animals. The animal peroxidases comprise a group of homologous proteins that differ markedly from the plant/fungal/bacterial peroxidases in primary, secondary and tertiary structure, but which share with them a common function. Animal peroxidases probably arose independently of the plant/fungal/bacterial peroxidase superfamily and most likely belong to a different gene family. The crystal structures of a number of these proteins show that the active sites of animal peroxidase and plant/fungal/bacterial peroxidases are remarkably similar [PubMed10403190].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heme-dependent peroxidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the Heme-dependent peroxidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]