SUPERFAMILY 1.75 HMM library and genome assignments server


Regulator of G-protein signaling, RGS superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Regulator of G-protein signaling, RGS [ 48096]
Superfamily:   Regulator of G-protein signaling, RGS [ 48097]
Families:   Regulator of G-protein signaling, RGS [ 48098] (9)


Superfamily statistics
Genomes (423) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,524 0 11
Proteins 5,969 0 11


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process1.405e-131.644e-07Least InformativeDirect
Biological Process (BP)response to stimulus3.251e-058.986e-13Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.0023950.01574Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0010051.608e-09Least InformativeInherited
Biological Process (BP)regulation of catalytic activity00Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction8.507e-110Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.00064271.922e-15Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00073445.893e-05Moderately InformativeDirect
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)signal transduction0.0016981.05e-12Moderately InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process00InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process00InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity00InformativeDirect
Biological Process (BP)regulation of cellular catabolic process3.164e-110InformativeDirect
Biological Process (BP)G-protein coupled receptor signaling pathway00Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway1.231e-110Highly InformativeDirect
Molecular Function (MF)binding0.0020410.3766Least InformativeInherited
Molecular Function (MF)enzyme regulator activity00Moderately InformativeDirect
Molecular Function (MF)enzyme activator activity00InformativeDirect
Molecular Function (MF)GTPase regulator activity00InformativeDirect
Molecular Function (MF)GTPase activator activity00Highly InformativeDirect
Cellular Component (CC)membrane0.0024962.049e-06Least InformativeInherited
Cellular Component (CC)cell projection0.00017245.865e-09Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.00030811.415e-09Moderately InformativeDirect
Cellular Component (CC)neuron projection2.359e-070.001528InformativeInherited
Cellular Component (CC)dendrite5.435e-100.001022Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1.644e-07 Least Informative Direct
Biological Process (BP) response to stimulus 8.986e-13 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.608e-09 Least Informative Direct
Biological Process (BP) developmental process 0.004094 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.005524 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.9432 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9975 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.01574 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.269 Least Informative Inherited
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1.922e-15 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 5.893e-05 Moderately Informative Direct
Biological Process (BP) signal transduction 1.05e-12 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.77 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.158 Moderately Informative Inherited
Biological Process (BP) organ development 0.5414 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1663 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.03946 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.004632 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.02461 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7092 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.02046 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of signaling 6.407e-11 Informative Direct
Biological Process (BP) negative regulation of cell communication 1.266e-09 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 1.224e-08 Informative Direct
Biological Process (BP) phosphorylation 2.826e-07 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0001531 Informative Direct
Biological Process (BP) response to light stimulus 0.0003806 Informative Direct
Biological Process (BP) generation of neurons 0.0004266 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0009906 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0.7 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.006303 Informative Inherited
Biological Process (BP) growth 0.3732 Informative Inherited
Biological Process (BP) regulation of cell development 0.07238 Informative Inherited
Biological Process (BP) organ morphogenesis 0.009556 Informative Inherited
Biological Process (BP) epithelium development 0.9402 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.3739 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.8555 Informative Inherited
Biological Process (BP) actin filament-based process 0.03939 Informative Inherited
Biological Process (BP) cellular component movement 0.6703 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.4424 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.5037 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.07245 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1259 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.004104 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.1528 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1814 Informative Inherited
Biological Process (BP) sexual reproduction 0.2375 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2414 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.002746 Informative Inherited
Biological Process (BP) regulation of system process 0.003364 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.003377 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) protein phosphorylation 2.704e-09 Highly Informative Direct
Biological Process (BP) actin filament-based movement 2.421e-08 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 9.003e-07 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 2.166e-05 Highly Informative Direct
Biological Process (BP) pattern specification process 2.616e-05 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0.006965 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) developmental growth 0.1011 Highly Informative Inherited
Biological Process (BP) cell growth 0.1097 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.1921 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.2742 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.6164 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.2698 Highly Informative Inherited
Biological Process (BP) ossification 0.008404 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.01807 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.08874 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.6681 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.3168 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 1 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.02142 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.05787 Highly Informative Inherited
Biological Process (BP) detection of light stimulus 0.001778 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.0191 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.03404 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.02753 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.02766 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.3139 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.004429 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.1396 Highly Informative Inherited
Molecular Function (MF) binding 0.3766 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 3.738e-12 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.09473 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1.558e-15 Informative Direct
Molecular Function (MF) kinase activity 2.892e-14 Informative Direct
Molecular Function (MF) enzyme binding 0.002069 Informative Inherited
Molecular Function (MF) receptor binding 0.4116 Informative Inherited
Molecular Function (MF) GTPase activator activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) kinase binding 0.004586 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 1 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 2.049e-06 Least Informative Direct
Cellular Component (CC) protein complex 0.9268 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.7668 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7594 Least Informative Inherited
Cellular Component (CC) cell projection 5.865e-09 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1.415e-09 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.005231 Moderately Informative Inherited
Cellular Component (CC) cell cortex 1.306e-10 Informative Direct
Cellular Component (CC) neuron projection 0.001528 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.2562 Informative Inherited
Cellular Component (CC) contractile ring 7.579e-11 Highly Informative Direct
Cellular Component (CC) cell division site part 1.908e-07 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 1.25e-06 Highly Informative Direct
Cellular Component (CC) dendrite 0.001022 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.007987 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01616Least InformativeInherited
Worm Phenotype (WP)mechanosensation variant3.114e-05InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)lifespan0.49InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)larva0.2299Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.01821Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval cuticle0.0006909InformativeDirect
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0001618Highly InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis7.588e-06Moderately InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processTranslation regulation0.0003013InformativeDirect
Biological processVision0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus6.04e-08Least InformativeDirect
Cellular componentEndosome0.0002656Moderately InformativeDirect
DomainCoiled coil2.227e-06Moderately InformativeDirect
Molecular functionLipid-binding2.399e-05InformativeDirect
Post-translational modificationTransferase0.6897Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein2.73e-12Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationGTPase activation4.432e-16InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor6.624e-10InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation8.169e-12Moderately InformativeDirect
Post-translational modificationADP-ribosylation8.182e-07InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Regulator of G-protein signaling, RGS domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Regulator of G-protein signaling, RGS superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]