SUPERFAMILY 1.75 HMM library and genome assignments server

Regulator of G-protein signaling, RGS superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Regulator of G-protein signaling, RGS [ 48096]
Superfamily:   Regulator of G-protein signaling, RGS [ 48097]
Families:   Regulator of G-protein signaling, RGS [ 48098] (9)


Superfamily statistics
Genomes (429) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,826 7,697 11
Proteins 6,239 7,092 11


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00000000000041360.0000004444Least InformativeDirect
Biological Process (BP)response to stimulus0.000045590.000000000002157Least InformativeDirect
Biological Process (BP)positive regulation of biological process0.0013350.0000000002606Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0033370.01353Least InformativeInherited
Biological Process (BP)single-organism cellular process0.026950.000006788Least InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.0000061210Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.00000000016460Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00015390.0000153Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.0005710.000000000000003707Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.00024510.000000001562Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity00Moderately InformativeDirect
Biological Process (BP)regulation of phosphorus metabolic process00Moderately InformativeDirect
Biological Process (BP)signal transduction0.0012540.0000000000003861Moderately InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process00InformativeDirect
Biological Process (BP)positive regulation of catabolic process00InformativeDirect
Biological Process (BP)regulation of cellular catabolic process0.000000000015840InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity00InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process00InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.0059310.0000000000004894InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway00Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.0000000000096320Highly InformativeDirect
Biological Process (BP)positive regulation of GTPase activity00Highly InformativeDirect
Molecular Function (MF)binding0.0033230.4682Least InformativeInherited
Molecular Function (MF)enzyme regulator activity00Moderately InformativeDirect
Molecular Function (MF)enzyme activator activity00InformativeDirect
Molecular Function (MF)GTPase activator activity00Highly InformativeDirect
Cellular Component (CC)membrane0.0040660.00000571Least InformativeInherited
Cellular Component (CC)cell projection0.0001990.000000001438Moderately InformativeDirect
Cellular Component (CC)neuron projection0.00000035290.004739InformativeInherited
Cellular Component (CC)dendrite0.00000000056320.0001676Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.000006788 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.0000000002606 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0000004444 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000000002157 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 0.007271 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.005935 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.9557 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.2991 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.01353 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) signal transduction 0.0000000000003861 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0000153 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000001562 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.5536 Moderately Informative Inherited
Biological Process (BP) tissue development 0.192 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1466 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1945 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.6211 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.02783 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.0399 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.5982 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.004676 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) response to light stimulus 0.0004222 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000000004803 Informative Direct
Biological Process (BP) phosphorylation 0.000000699 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0000000002454 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0000000000004894 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00000005257 Informative Direct
Biological Process (BP) generation of neurons 0.0004801 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.007257 Informative Inherited
Biological Process (BP) growth 0.5437 Informative Inherited
Biological Process (BP) regulation of MAPK cascade 0.06578 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 0.1332 Informative Inherited
Biological Process (BP) actin filament-based process 0.01731 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.001128 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.004471 Informative Inherited
Biological Process (BP) cellular component movement 0.426 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.4626 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.3815 Informative Inherited
Biological Process (BP) regulation of system process 0.01901 Informative Inherited
Biological Process (BP) organ morphogenesis 0.03565 Informative Inherited
Biological Process (BP) epithelium development 0.1984 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1613 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.0864 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.009345 Informative Inherited
Biological Process (BP) sexual reproduction 0.5919 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.03937 Informative Inherited
Biological Process (BP) single organism reproductive process 0.9028 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.07536 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.8713 Informative Inherited
Biological Process (BP) protein phosphorylation 0.000000002283 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) pattern specification process 0.00009618 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 0.000001357 Highly Informative Direct
Biological Process (BP) actin filament-based movement 0.00000002277 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0003099 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.00006387 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.0003609 Highly Informative Direct
Biological Process (BP) positive regulation of protein modification by small protein conjugation or removal 0.0002967 Highly Informative Direct
Biological Process (BP) cell growth 0.07009 Highly Informative Inherited
Biological Process (BP) developmental growth 0.1073 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.3689 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.1731 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.01568 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.9497 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.359 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 1 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.9256 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0575 Highly Informative Inherited
Biological Process (BP) detection of light stimulus 0.0016 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.03928 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.02526 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.02471 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.0001918 Least Informative Direct
Molecular Function (MF) binding 0.4682 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000000004074 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.09148 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) kinase activity 0.0000000000000281 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 8.141e-16 Informative Direct
Molecular Function (MF) enzyme binding 0.006445 Informative Inherited
Molecular Function (MF) receptor binding 0.3903 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0001281 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0 Highly Informative Direct
Molecular Function (MF) kinase binding 0.002161 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0.00000571 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6267 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.8462 Least Informative Inherited
Cellular Component (CC) cell projection 0.000000001438 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.007662 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.1518 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0.00000000009352 Informative Direct
Cellular Component (CC) neuron projection 0.004739 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.2339 Informative Inherited
Cellular Component (CC) dendrite 0.0001676 Highly Informative Direct
Cellular Component (CC) cell division site part 0.0000002088 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.006979 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01616Least InformativeInherited
Worm Phenotype (WP)mechanosensation variant0.00003114InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)lifespan0.4913InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)larva0.2221Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.01616Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.003113InformativeInherited
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0001514Highly InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.000007513Moderately InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processTranslation regulation0.0003005InformativeDirect
Biological processVision0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.00000006035Least InformativeDirect
Cellular componentEndosome0.000274Moderately InformativeDirect
DomainCoiled coil0.0000004951Moderately InformativeDirect
Molecular functionLipid-binding0.00002387InformativeDirect
Post-translational modificationTransferase0.6905Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000000002585Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationGTPase activation4.449e-16InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0000000006509InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00000000001144Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.0000008158InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Regulator of G-protein signaling, RGS domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Regulator of G-protein signaling, RGS superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]