SUPERFAMILY 1.75 HMM library and genome assignments server


Regulator of G-protein signaling, RGS superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Regulator of G-protein signaling, RGS [ 48096]
Superfamily:   Regulator of G-protein signaling, RGS [ 48097]
Families:   Regulator of G-protein signaling, RGS [ 48098] (9)


Superfamily statistics
Genomes (394) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 6,166 5,691 11
Proteins 5,688 5,263 11


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process7.949e-070.0005715Least InformativeDirect
Biological Process (BP)regulation of cellular process07.073e-08Least InformativeDirect
Biological Process (BP)response to stimulus0.0010321.46e-09Least InformativeInherited
Biological Process (BP)single-organism cellular process0.002151.707e-06Least InformativeInherited
Biological Process (BP)regulation of cellular metabolic process1.83e-081.126e-05Moderately InformativeDirect
Biological Process (BP)regulation of nitrogen compound metabolic process01.119e-11Moderately InformativeDirect
Biological Process (BP)regulation of molecular function00Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.00110Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.0044231.53e-14Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.03591.103e-10Moderately InformativeInherited
Biological Process (BP)signal transduction0.029891.731e-08Moderately InformativeInherited
Biological Process (BP)negative regulation of signaling0.00088191.317e-12InformativeDirect
Biological Process (BP)regulation of cellular catabolic process00InformativeDirect
Biological Process (BP)positive regulation of catalytic activity00InformativeDirect
Biological Process (BP)regulation of hydrolase activity00InformativeDirect
Biological Process (BP)G-protein coupled receptor signaling pathway00Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway2.614e-140Highly InformativeDirect
Biological Process (BP)regulation of nucleoside metabolic process00Highly InformativeDirect
Biological Process (BP)regulation of purine nucleotide catabolic process00Highly InformativeDirect
Molecular Function (MF)binding0.070420.9395Least InformativeInherited
Molecular Function (MF)protein binding0.00012441.254e-05Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity00Moderately InformativeDirect
Molecular Function (MF)enzyme activator activity00InformativeDirect
Molecular Function (MF)GTPase regulator activity00InformativeDirect
Molecular Function (MF)GTPase activator activity00Highly InformativeDirect
Cellular Component (CC)membrane2.389e-052.136e-10Least InformativeDirect
Cellular Component (CC)plasma membrane3.16e-073.129e-15Moderately InformativeDirect
Cellular Component (CC)cell projection0.00056291.909e-06Moderately InformativeDirect
Cellular Component (CC)cell projection part5.881e-063.611e-06InformativeDirect
Cellular Component (CC)neuron part1.234e-054.068e-09InformativeDirect
Cellular Component (CC)dendrite3.289e-090.001237Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.0005715 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.707e-06 Least Informative Direct
Biological Process (BP) regulation of cellular process 7.073e-08 Least Informative Direct
Biological Process (BP) response to stimulus 1.46e-09 Least Informative Direct
Biological Process (BP) developmental process 0.0658 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.03377 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.5106 Least Informative Inherited
Biological Process (BP) signal transduction 1.731e-08 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 1.53e-14 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 1.126e-05 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1.103e-10 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 1.119e-11 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.8345 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.4256 Moderately Informative Inherited
Biological Process (BP) reproduction 0.226 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.01531 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.02812 Moderately Informative Inherited
Biological Process (BP) tissue development 0.641 Moderately Informative Inherited
Biological Process (BP) organ development 0.3317 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1205 Moderately Informative Inherited
Biological Process (BP) protein phosphorylation 3.691e-08 Informative Direct
Biological Process (BP) negative regulation of cell communication 3.151e-11 Informative Direct
Biological Process (BP) negative regulation of signaling 1.317e-12 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 9.145e-10 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0005611 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.04882 Informative Inherited
Biological Process (BP) regulation of cell development 0.191 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of reproductive process 0.5871 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.1911 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.9397 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.00529 Informative Inherited
Biological Process (BP) actin filament-based process 0.1414 Informative Inherited
Biological Process (BP) positive regulation of phosphorus metabolic process 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.3022 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.07581 Informative Inherited
Biological Process (BP) growth 0.6013 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.869 Informative Inherited
Biological Process (BP) organ morphogenesis 0.004512 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1173 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.09443 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.05251 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9325 Informative Inherited
Biological Process (BP) sexual reproduction 0.0525 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1505 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.1727 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1303 Informative Inherited
Biological Process (BP) regulation of system process 0.00333 Informative Inherited
Biological Process (BP) chordate embryonic development 1 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) gastrulation 9.404e-05 Highly Informative Direct
Biological Process (BP) pattern specification process 5.527e-05 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 1.075e-06 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0.01162 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) cell growth 0.07931 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.1206 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.157 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.5761 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.002385 Highly Informative Inherited
Biological Process (BP) ossification 0.005687 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.6341 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.3187 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.0181 Highly Informative Inherited
Biological Process (BP) developmental growth 0.06242 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 0.005173 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.01128 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.02262 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.01608 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.003575 Highly Informative Inherited
Molecular Function (MF) transferase activity 2.413e-05 Least Informative Direct
Molecular Function (MF) binding 0.9395 Least Informative Inherited
Molecular Function (MF) protein binding 1.254e-05 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 5.523e-12 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.1105 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) kinase activity 3.027e-14 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1.562e-15 Informative Direct
Molecular Function (MF) enzyme binding 0.0003371 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.6272 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 1 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 2.136e-10 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.8186 Least Informative Inherited
Cellular Component (CC) plasma membrane 3.129e-15 Moderately Informative Direct
Cellular Component (CC) cell projection 1.909e-06 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.004296 Moderately Informative Inherited
Cellular Component (CC) cell cortex 7.3e-09 Informative Direct
Cellular Component (CC) cell projection part 3.611e-06 Informative Direct
Cellular Component (CC) neuron part 4.068e-09 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.3519 Informative Inherited
Cellular Component (CC) cell division site part 4.33e-06 Highly Informative Direct
Cellular Component (CC) dendrite 0.001237 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.01265 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01616Least InformativeInherited
Worm Phenotype (WP)mechanosensation variant3.114e-05InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)larva0.2175Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)cuticle0.2322Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval cuticle0.0008061InformativeDirect
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0001998Highly InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis5.799e-06Moderately InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processTranslation regulation0.0002537InformativeDirect
Biological processVision0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus3.084e-07Least InformativeDirect
Cellular componentEndosome0.0001158Moderately InformativeDirect
DomainCoiled coil7.307e-06Moderately InformativeDirect
Molecular functionLipid-binding1.193e-05InformativeDirect
Post-translational modificationTransferase0.719Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein2.739e-12Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationGTPase activation4.42e-16InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor7.316e-10InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation2.136e-08Moderately InformativeDirect
Post-translational modificationPalmitate0.0007936Moderately InformativeDirect
Post-translational modificationADP-ribosylation2.149e-06InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Regulator of G-protein signaling, RGS domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Regulator of G-protein signaling, RGS superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]