SUPERFAMILY 1.75 HMM library and genome assignments server


Regulator of G-protein signaling, RGS superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Regulator of G-protein signaling, RGS [ 48096]
Superfamily:   Regulator of G-protein signaling, RGS [ 48097]
Families:   Regulator of G-protein signaling, RGS [ 48098] (9)


Superfamily statistics
Genomes (429) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,826 7,697 11
Proteins 6,239 7,092 11


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process1.936e-131.624e-07Least InformativeDirect
Biological Process (BP)response to stimulus3.958e-051.049e-12Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.002190.01108Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0010232.856e-09Least InformativeInherited
Biological Process (BP)regulation of catalytic activity00Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction1.055e-100Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.0006613.77e-15Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00070155.955e-05Moderately InformativeDirect
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)signal transduction0.0016957.495e-13Moderately InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process00InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process00InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity00InformativeDirect
Biological Process (BP)regulation of cellular catabolic process3.1e-110InformativeDirect
Biological Process (BP)G-protein coupled receptor signaling pathway00Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway1.112e-110Highly InformativeDirect
Molecular Function (MF)binding0.0026350.4254Least InformativeInherited
Molecular Function (MF)enzyme regulator activity00Moderately InformativeDirect
Molecular Function (MF)enzyme activator activity00InformativeDirect
Molecular Function (MF)GTPase regulator activity00InformativeDirect
Molecular Function (MF)GTPase activator activity00Highly InformativeDirect
Cellular Component (CC)membrane0.0037064.863e-06Least InformativeInherited
Cellular Component (CC)cell projection0.00015846.385e-09Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.00049456.422e-09Moderately InformativeDirect
Cellular Component (CC)neuron projection2.543e-070.001547InformativeInherited
Cellular Component (CC)dendrite6.237e-100.001075Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1.624e-07 Least Informative Direct
Biological Process (BP) response to stimulus 1.049e-12 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.856e-09 Least Informative Direct
Biological Process (BP) developmental process 0.006662 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.94 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.01108 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.008616 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.2655 Least Informative Inherited
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 3.77e-15 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 5.955e-05 Moderately Informative Direct
Biological Process (BP) signal transduction 7.495e-13 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.8055 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1275 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.5955 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.196 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.03461 Moderately Informative Inherited
Biological Process (BP) reproduction 0.02379 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.004375 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.02388 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of signaling 5.661e-11 Informative Direct
Biological Process (BP) negative regulation of cell communication 1.178e-09 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 1.036e-08 Informative Direct
Biological Process (BP) phosphorylation 2.646e-07 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0001579 Informative Direct
Biological Process (BP) response to light stimulus 0.0003914 Informative Direct
Biological Process (BP) generation of neurons 0.0004468 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0.6986 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.006753 Informative Inherited
Biological Process (BP) growth 0.518 Informative Inherited
Biological Process (BP) epithelium development 0.8348 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.8536 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.001097 Informative Inherited
Biological Process (BP) actin filament-based process 0.0398 Informative Inherited
Biological Process (BP) cellular component movement 0.6526 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.4429 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.4078 Informative Inherited
Biological Process (BP) organ morphogenesis 0.01636 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.06644 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1122 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.008467 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.08542 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1002 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1502 Informative Inherited
Biological Process (BP) sexual reproduction 0.1729 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9322 Informative Inherited
Biological Process (BP) regulation of system process 0.00228 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.004665 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) protein phosphorylation 2.534e-09 Highly Informative Direct
Biological Process (BP) actin filament-based movement 2.375e-08 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 1.081e-06 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 2.228e-05 Highly Informative Direct
Biological Process (BP) pattern specification process 7.259e-05 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0.007335 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) developmental growth 0.08809 Highly Informative Inherited
Biological Process (BP) cell growth 0.1061 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.1855 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.2684 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.5907 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.01555 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.09471 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.7058 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.3211 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 1 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.02129 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.05729 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.9355 Highly Informative Inherited
Biological Process (BP) detection of light stimulus 0.001718 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.01647 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.03263 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.02619 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.01364 Highly Informative Inherited
Molecular Function (MF) transferase activity 1.617e-05 Least Informative Direct
Molecular Function (MF) binding 0.4254 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 3.518e-12 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.09532 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 8.007e-16 Informative Direct
Molecular Function (MF) kinase activity 2.762e-14 Informative Direct
Molecular Function (MF) enzyme binding 0.005511 Informative Inherited
Molecular Function (MF) receptor binding 0.3937 Informative Inherited
Molecular Function (MF) GTPase activator activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) kinase binding 0.002235 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 1 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 4.863e-06 Least Informative Direct
Cellular Component (CC) protein complex 0.9304 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.7705 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7317 Least Informative Inherited
Cellular Component (CC) cell projection 6.385e-09 Moderately Informative Direct
Cellular Component (CC) plasma membrane 6.422e-09 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.005305 Moderately Informative Inherited
Cellular Component (CC) cell cortex 9.383e-11 Informative Direct
Cellular Component (CC) neuron projection 0.001547 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.263 Informative Inherited
Cellular Component (CC) cell division site part 1.961e-07 Highly Informative Direct
Cellular Component (CC) dendrite 0.001075 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.007804 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01616Least InformativeInherited
Worm Phenotype (WP)mechanosensation variant3.114e-05InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)lifespan0.4893InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)larva0.2232Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.01607Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.003087InformativeInherited
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0001507Highly InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis7.509e-06Moderately InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processTranslation regulation0.0002992InformativeDirect
Biological processVision0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus5.811e-08Least InformativeDirect
Cellular componentEndosome0.0002633Moderately InformativeDirect
DomainCoiled coil2.217e-06Moderately InformativeDirect
Molecular functionLipid-binding2.382e-05InformativeDirect
Post-translational modificationTransferase0.6907Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein2.658e-12Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationGTPase activation4.442e-16InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor6.552e-10InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation9.957e-12Moderately InformativeDirect
Post-translational modificationADP-ribosylation8.241e-07InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Regulator of G-protein signaling, RGS domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Regulator of G-protein signaling, RGS superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]