SUPERFAMILY 1.75 HMM library and genome assignments server


Regulator of G-protein signaling, RGS superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Regulator of G-protein signaling, RGS [ 48096]
Superfamily:   Regulator of G-protein signaling, RGS [ 48097]
Families:   Regulator of G-protein signaling, RGS [ 48098] (9)


Superfamily statistics
Genomes (429) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,826 7,697 11
Proteins 6,239 7,092 11


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process2.715e-131.547e-07Least InformativeDirect
Biological Process (BP)response to stimulus4.658e-051.436e-12Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00097763.221e-09Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.0021770.01205Least InformativeInherited
Biological Process (BP)regulation of catalytic activity00Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction1.363e-100Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.00055071.938e-15Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00067754.815e-05Moderately InformativeDirect
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)signal transduction0.0015584.101e-13Moderately InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process00InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process00InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity00InformativeDirect
Biological Process (BP)regulation of cellular catabolic process2.061e-110InformativeDirect
Biological Process (BP)G-protein coupled receptor signaling pathway00Highly InformativeDirect
Biological Process (BP)positive regulation of GTPase activity00Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway1.173e-110Highly InformativeDirect
Molecular Function (MF)binding0.0031830.4411Least InformativeInherited
Molecular Function (MF)enzyme regulator activity00Moderately InformativeDirect
Molecular Function (MF)enzyme activator activity00InformativeDirect
Molecular Function (MF)GTPase regulator activity00InformativeDirect
Molecular Function (MF)GTPase activator activity00Highly InformativeDirect
Cellular Component (CC)membrane0.0040484.893e-06Least InformativeInherited
Cellular Component (CC)cell projection0.00018251.047e-08Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.00053427.364e-09Moderately InformativeDirect
Cellular Component (CC)neuron projection3.488e-070.001731InformativeInherited
Cellular Component (CC)dendrite8.385e-100.000938Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1.547e-07 Least Informative Direct
Biological Process (BP) response to stimulus 1.436e-12 Least Informative Direct
Biological Process (BP) single-organism cellular process 3.221e-09 Least Informative Direct
Biological Process (BP) developmental process 0.006422 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.9436 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.01205 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.008437 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.2676 Least Informative Inherited
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1.938e-15 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 4.815e-05 Moderately Informative Direct
Biological Process (BP) signal transduction 4.101e-13 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.8069 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1315 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.5978 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1953 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.03367 Moderately Informative Inherited
Biological Process (BP) reproduction 0.04071 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.004323 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.02511 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of signaling 6.872e-11 Informative Direct
Biological Process (BP) negative regulation of cell communication 1.359e-09 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 1.212e-08 Informative Direct
Biological Process (BP) phosphorylation 2.28e-07 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.000152 Informative Direct
Biological Process (BP) response to light stimulus 0.0004038 Informative Direct
Biological Process (BP) generation of neurons 0.0004343 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.04798 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.006611 Informative Inherited
Biological Process (BP) growth 0.5408 Informative Inherited
Biological Process (BP) epithelium development 0.8381 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.8622 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.001065 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.03932 Informative Inherited
Biological Process (BP) cellular component movement 0.6425 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.4538 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.4076 Informative Inherited
Biological Process (BP) organ morphogenesis 0.01614 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.06417 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1151 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.008976 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.08592 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1505 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1698 Informative Inherited
Biological Process (BP) sexual reproduction 0.2406 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9346 Informative Inherited
Biological Process (BP) regulation of system process 0.002636 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.004437 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) protein phosphorylation 2.087e-09 Highly Informative Direct
Biological Process (BP) actin filament-based movement 2.344e-08 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 1.237e-06 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 6.296e-05 Highly Informative Direct
Biological Process (BP) pattern specification process 6.744e-05 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0.007298 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) developmental growth 0.08483 Highly Informative Inherited
Biological Process (BP) cell growth 0.1075 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.1904 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.2679 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.5918 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.01509 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.6927 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.3407 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 1 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.02117 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.1256 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.05833 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.9282 Highly Informative Inherited
Biological Process (BP) detection of light stimulus 0.001672 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.01643 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.03269 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.02491 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.00694 Highly Informative Inherited
Molecular Function (MF) transferase activity 1.898e-05 Least Informative Direct
Molecular Function (MF) binding 0.4411 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 3.497e-12 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.09247 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 8.006e-16 Informative Direct
Molecular Function (MF) kinase activity 2.473e-14 Informative Direct
Molecular Function (MF) enzyme binding 0.006163 Informative Inherited
Molecular Function (MF) receptor binding 0.3935 Informative Inherited
Molecular Function (MF) GTPase activator activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) kinase binding 0.002085 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 1 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 4.893e-06 Least Informative Direct
Cellular Component (CC) protein complex 0.9277 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.7575 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7447 Least Informative Inherited
Cellular Component (CC) cell projection 1.047e-08 Moderately Informative Direct
Cellular Component (CC) plasma membrane 7.364e-09 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.005361 Moderately Informative Inherited
Cellular Component (CC) cell cortex 9.786e-11 Informative Direct
Cellular Component (CC) neuron projection 0.001731 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.2675 Informative Inherited
Cellular Component (CC) dendrite 0.000938 Highly Informative Direct
Cellular Component (CC) cell division site part 2.065e-07 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.007792 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01616Least InformativeInherited
Worm Phenotype (WP)mechanosensation variant3.114e-05InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)lifespan0.4913InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)larva0.2221Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.01616Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.003113InformativeInherited
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0001514Highly InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis7.513e-06Moderately InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processTranslation regulation0.0003005InformativeDirect
Biological processVision0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus6.035e-08Least InformativeDirect
Cellular componentEndosome0.000274Moderately InformativeDirect
DomainCoiled coil4.951e-07Moderately InformativeDirect
Molecular functionLipid-binding2.387e-05InformativeDirect
Post-translational modificationTransferase0.6905Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein2.585e-12Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationGTPase activation4.449e-16InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor6.509e-10InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation1.144e-11Moderately InformativeDirect
Post-translational modificationADP-ribosylation8.158e-07InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Regulator of G-protein signaling, RGS domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Regulator of G-protein signaling, RGS superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]