SUPERFAMILY 1.75 HMM library and genome assignments server


Transcription factor STAT-4 N-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transcription factor STAT-4 N-domain [ 48091]
Superfamily:   Transcription factor STAT-4 N-domain [ 48092]
Families:   Transcription factor STAT-4 N-domain [ 48093]


Superfamily statistics
Genomes (101) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 570 686 1
Proteins 570 684 1


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)single-organism cellular process04.382e-14Least InformativeDirect
Biological Process (BP)regulation of metabolic process08.434e-08Least InformativeDirect
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)organ development00Moderately InformativeDirect
Biological Process (BP)regulation of nitrogen compound metabolic process00Moderately InformativeDirect
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)cell differentiation00Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process04.008e-15Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process02.579e-13Moderately InformativeDirect
Biological Process (BP)regulation of developmental process01.861e-12Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process02.038e-12Moderately InformativeDirect
Biological Process (BP)single-organism developmental process01.03e-09Moderately InformativeDirect
Biological Process (BP)regulation of cellular metabolic process02.531e-09Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus08.289e-06Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process00.0003367Moderately InformativeDirect
Biological Process (BP)tissue development00.001009Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis00.5613Moderately InformativeInherited
Biological Process (BP)positive regulation of gene expression00InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process04.008e-15InformativeDirect
Biological Process (BP)regulation of cell proliferation05.966e-15InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process02.442e-14InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process04.534e-13InformativeDirect
Biological Process (BP)cell activation03.315e-09InformativeDirect
Biological Process (BP)gland development02.794e-07InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development06.722e-07InformativeDirect
Biological Process (BP)regulation of transcription from RNA polymerase II promoter00.0004611InformativeDirect
Biological Process (BP)epithelium development01InformativeInherited
Biological Process (BP)positive regulation of immune system process00.001236InformativeInherited
Biological Process (BP)regulation of immune effector process00.006291InformativeInherited
Biological Process (BP)lymphocyte differentiation00Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte activation00Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte mediated immunity01.905e-13Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation01.213e-07Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development08.325e-07Highly InformativeDirect
Biological Process (BP)positive regulation of immune effector process00.0001698Highly InformativeDirect
Molecular Function (MF)binding09.144e-07Least InformativeDirect
Molecular Function (MF)heterocyclic compound binding00Moderately InformativeDirect
Molecular Function (MF)organic cyclic compound binding00Moderately InformativeDirect
Molecular Function (MF)DNA binding00InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 4.382e-14 Least Informative Direct
Biological Process (BP) regulation of metabolic process 8.434e-08 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000533 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.02173 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.09014 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.005499 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.01884 Least Informative Inherited
Biological Process (BP) localization 0.00578 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.003556 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 4.008e-15 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 2.579e-13 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1.861e-12 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 2.038e-12 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.03e-09 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 2.531e-09 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 8.289e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0003367 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) reproduction 1.136e-13 Moderately Informative Direct
Biological Process (BP) response to organic substance 2.364e-12 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 8.706e-12 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 5.3e-10 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 1.267e-09 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 1.834e-09 Moderately Informative Direct
Biological Process (BP) multi-organism process 5.162e-09 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 5.681e-09 Moderately Informative Direct
Biological Process (BP) homeostatic process 8.472e-09 Moderately Informative Direct
Biological Process (BP) macromolecule localization 2.479e-07 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 5.147e-07 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 1.125e-06 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 3.355e-05 Moderately Informative Direct
Biological Process (BP) gene expression 4.04e-05 Moderately Informative Direct
Biological Process (BP) tissue development 0.001009 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.09995 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5613 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8868 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.1021 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.03958 Moderately Informative Inherited
Biological Process (BP) system process 0.02061 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.07632 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.06184 Moderately Informative Inherited
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 4.008e-15 Informative Direct
Biological Process (BP) regulation of cell proliferation 5.966e-15 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 2.442e-14 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 4.534e-13 Informative Direct
Biological Process (BP) cell activation 3.315e-09 Informative Direct
Biological Process (BP) gland development 2.794e-07 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 6.722e-07 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0004611 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) cell proliferation 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) apoptotic process 2.854e-12 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 3.341e-12 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 3.546e-11 Informative Direct
Biological Process (BP) regulation of hydrolase activity 4.846e-11 Informative Direct
Biological Process (BP) intracellular signal transduction 3.284e-10 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 1.288e-09 Informative Direct
Biological Process (BP) regulation of growth 1.723e-09 Informative Direct
Biological Process (BP) response to organic nitrogen 4.06e-09 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 2.392e-08 Informative Direct
Biological Process (BP) defense response 2.695e-08 Informative Direct
Biological Process (BP) secretion 5.416e-08 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 7.933e-08 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.27e-07 Informative Direct
Biological Process (BP) multi-organism reproductive process 3.433e-07 Informative Direct
Biological Process (BP) generation of neurons 2.531e-06 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 7.432e-06 Informative Direct
Biological Process (BP) response to hormone stimulus 1.6e-05 Informative Direct
Biological Process (BP) immune response 2.19e-05 Informative Direct
Biological Process (BP) nucleocytoplasmic transport 6.837e-05 Informative Direct
Biological Process (BP) protein phosphorylation 9.602e-05 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0001581 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0001774 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0007104 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.000829 Informative Direct
Biological Process (BP) protein localization to organelle 0.0009516 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.02363 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.2229 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.2777 Informative Inherited
Biological Process (BP) reproductive system development 0.03159 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.004594 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.001236 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01784 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.05771 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.004204 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.001904 Informative Inherited
Biological Process (BP) single organism reproductive process 0.001295 Informative Inherited
Biological Process (BP) regulation of immune response 0.1238 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.006291 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.8174 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.009393 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.008134 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.01292 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.002384 Informative Inherited
Biological Process (BP) response to lipid 0.9319 Informative Inherited
Biological Process (BP) regulation of response to stress 0.2231 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.009714 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.6361 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) response to external stimulus 0.03616 Informative Inherited
Biological Process (BP) protein transport 0.009475 Informative Inherited
Biological Process (BP) organ morphogenesis 0.007137 Informative Inherited
Biological Process (BP) sensory organ development 0.002985 Informative Inherited
Biological Process (BP) lymphocyte differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte activation 0 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 1.905e-13 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 1.213e-07 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 8.325e-07 Highly Informative Direct
Biological Process (BP) positive regulation of immune effector process 0.0001698 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 0 Highly Informative Direct
Biological Process (BP) feeding behavior 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 2.076e-15 Highly Informative Direct
Biological Process (BP) lactation 4.008e-15 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 2.615e-14 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 9.629e-13 Highly Informative Direct
Biological Process (BP) kidney development 5.471e-11 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 8.027e-11 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 4.476e-10 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 6.245e-10 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 1.374e-09 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 2.072e-09 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 2.232e-09 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 2.434e-08 Highly Informative Direct
Biological Process (BP) gonad development 5.559e-08 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 6.081e-08 Highly Informative Direct
Biological Process (BP) eye morphogenesis 1.706e-07 Highly Informative Direct
Biological Process (BP) cellular response to peptide hormone stimulus 2.82e-07 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 4.491e-07 Highly Informative Direct
Biological Process (BP) stem cell proliferation 5.236e-07 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 7.16e-07 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 7.716e-07 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 8.257e-07 Highly Informative Direct
Biological Process (BP) regulation of cell killing 9.381e-07 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 2.293e-06 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 2.463e-06 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 6.715e-06 Highly Informative Direct
Biological Process (BP) positive regulation of growth 3.342e-05 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 9.264e-05 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine phosphorylation 0.0001217 Highly Informative Direct
Biological Process (BP) nuclear import 0.0001306 Highly Informative Direct
Biological Process (BP) innate immune response 0.0003728 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0004838 Highly Informative Direct
Biological Process (BP) protein import 0.0005655 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.000594 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.01576 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.0016 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.002278 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1264 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.001257 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.0497 Highly Informative Inherited
Biological Process (BP) stem cell development 0.01697 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.004192 Highly Informative Inherited
Molecular Function (MF) binding 9.144e-07 Least Informative Direct
Molecular Function (MF) heterocyclic compound binding 0 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.9806 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 4.795e-07 Informative Direct
Molecular Function (MF) molecular transducer activity 8.826e-07 Informative Direct
Molecular Function (MF) enzyme binding 0.000357 Informative Direct
Molecular Function (MF) receptor binding 0.0347 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.4404 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 4.455e-10 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.3953 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.5133 Moderately Informative Inherited
Cellular Component (CC) neuron part 0.1207 Informative Inherited
Cellular Component (CC) dendrite 1.955e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.0157Least InformativeInherited
Disease Ontology (DO)organ system cancer0.02754Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.0001659Moderately InformativeDirect
Disease Ontology (DO)lung disease0.0005279Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.007541Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7828Moderately InformativeInherited
Disease Ontology (DO)kidney disease1Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease2.56e-07InformativeDirect
Disease Ontology (DO)chronic leukemia3.096e-05InformativeDirect
Disease Ontology (DO)nephritis0.0001724InformativeDirect
Disease Ontology (DO)myeloid leukemia0.1388InformativeInherited
Disease Ontology (DO)ulcerative colitis3.247e-08Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome5.66e-06Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.01272Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level3.426e-06Moderately InformativeDirect
Mammalian Phenotype (MP)tumorigenesis0.0003802Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.001067Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid level0.001837Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.003884Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.02906Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.03366Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.03899Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03986Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.04187Moderately InformativeInherited
Mammalian Phenotype (MP)behavior/neurological phenotype0.1175Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.3214Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.3301Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.8186Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level6.579e-09InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level9.728e-09InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion2.904e-07InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology9.304e-06InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive thermogenesis9.596e-05InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0004401InformativeDirect
Mammalian Phenotype (MP)abnormal antigen presentation0.001046InformativeInherited
Mammalian Phenotype (MP)abnormal innate immunity0.002444InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.003105InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.006159InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.006235InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.009473InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.02643InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05869InformativeInherited
Mammalian Phenotype (MP)abnormal cell proliferation0.07453InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.07634InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.1044InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.1187InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1629InformativeInherited
Mammalian Phenotype (MP)abnormal circulating hormone level0.2603InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology0.2684InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.4184InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.4428InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.6261InformativeInherited
Mammalian Phenotype (MP)abnormal level of surface class II molecules3.986e-07Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion1.971e-06Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis3.33e-06Highly InformativeDirect
Mammalian Phenotype (MP)increased percent body fat4.856e-06Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity5.787e-06Highly InformativeDirect
Mammalian Phenotype (MP)polyphagia7.3e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level9.167e-06Highly InformativeDirect
Mammalian Phenotype (MP)increased total body fat amount2.4e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level5.223e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level9.492e-05Highly InformativeDirect
Mammalian Phenotype (MP)small thymus9.764e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.0001811Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0002843Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor incidence0.0003226Highly InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.0003472Highly InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine pancreas morphology0.000441Highly InformativeDirect
Mammalian Phenotype (MP)impaired glucose tolerance0.0005317Highly InformativeDirect
Mammalian Phenotype (MP)increased body weight0.0008695Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ovary morphology0.00111Highly InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.02259Highly InformativeInherited
Mammalian Phenotype (MP)abnormal liver size0.07137Highly InformativeInherited

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainSH2 domain0InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013799 SSF48092 Protein matches
Abstract

This entry represents the N-terminal domain, which is responsible for protein interactions. This domain has a multi-helical structure that can be subdivided into two structural sub-domains.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transcription factor STAT-4 N-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Transcription factor STAT-4 N-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]