SUPERFAMILY 1.75 HMM library and genome assignments server

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Transcription factor STAT-4 N-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transcription factor STAT-4 N-domain [ 48091]
Superfamily:   Transcription factor STAT-4 N-domain [ 48092]
Families:   Transcription factor STAT-4 N-domain [ 48093]


Superfamily statistics
Genomes (120) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 629 955 1
Proteins 629 952 1


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)single-organism cellular process00.00000000000002782Least InformativeDirect
Biological Process (BP)regulation of metabolic process00.0000001638Least InformativeDirect
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)organ development00Moderately InformativeDirect
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of developmental process00Moderately InformativeDirect
Biological Process (BP)cell differentiation00Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process00Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process00.000000000001167Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00.000000000001384Moderately InformativeDirect
Biological Process (BP)single-organism developmental process00.000000002116Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process00.0000008125Moderately InformativeDirect
Biological Process (BP)tissue development00.001276Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis00.5194Moderately InformativeInherited
Biological Process (BP)positive regulation of gene expression00InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process00InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process00.000000000000001931InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process00.00000000000003117InformativeDirect
Biological Process (BP)regulation of transcription from RNA polymerase II promoter00.000000009629InformativeDirect
Biological Process (BP)gland development00.0000001152InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development00.000002799InformativeDirect
Biological Process (BP)leukocyte activation00.0005482InformativeDirect
Biological Process (BP)epithelium development01InformativeInherited
Biological Process (BP)positive regulation of immune system process00.001132InformativeInherited
Biological Process (BP)regulation of immune effector process00.01414InformativeInherited
Biological Process (BP)positive regulation of transcription, DNA-dependent00.0000000000001143Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte mediated immunity00.000000000000173Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation00.00000006765Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development00.0000002966Highly InformativeDirect
Molecular Function (MF)binding00.0000004117Least InformativeDirect
Molecular Function (MF)nucleic acid binding00Moderately InformativeDirect
Molecular Function (MF)DNA binding00InformativeDirect
Molecular Function (MF)transcription regulatory region DNA binding00.0000000005245Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000000002782 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0000001638 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000002954 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0003983 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0005933 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.002269 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.001213 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.01234 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.003141 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000000001167 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000000000001384 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.000000002116 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000008125 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000000000000003741 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000000000000003741 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000000000002952 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000000000004474 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00000000001417 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.00000000002934 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000000004781 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.000000006633 Moderately Informative Direct
Biological Process (BP) gene expression 0.000000007129 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000002073 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00000002132 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000002373 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.000315 Moderately Informative Direct
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.001276 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.009218 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7147 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.7335 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.7888 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5194 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02727 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8809 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.905 Moderately Informative Inherited
Biological Process (BP) system process 0.02326 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.3006 Moderately Informative Inherited
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000000000000001931 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00000000000003117 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000000009629 Informative Direct
Biological Process (BP) gland development 0.0000001152 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.000002799 Informative Direct
Biological Process (BP) leukocyte activation 0.0005482 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) response to nutrient levels 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) apoptotic process 0.000000000000003741 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0000000000007131 Informative Direct
Biological Process (BP) regulation of defense response 0.0000000000008305 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.00000000001206 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00000000003401 Informative Direct
Biological Process (BP) regulation of growth 0.0000000006427 Informative Direct
Biological Process (BP) response to hormone stimulus 0.000000004815 Informative Direct
Biological Process (BP) phosphorylation 0.000000008703 Informative Direct
Biological Process (BP) lipid localization 0.00000002215 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.00000002995 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00000004614 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00000008745 Informative Direct
Biological Process (BP) defense response 0.000000312 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000003531 Informative Direct
Biological Process (BP) generation of neurons 0.0000006037 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0000006768 Informative Direct
Biological Process (BP) immune response 0.000002189 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.00001286 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0002983 Informative Direct
Biological Process (BP) protein localization to organelle 0.0004626 Informative Direct
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.04689 Informative Inherited
Biological Process (BP) regulation of locomotion 0.1122 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.001725 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.2193 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.2541 Informative Inherited
Biological Process (BP) reproductive system development 0.0343 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.002111 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001933 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.001132 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.05941 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.07294 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.001011 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.009858 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02204 Informative Inherited
Biological Process (BP) single organism reproductive process 0.001973 Informative Inherited
Biological Process (BP) regulation of immune response 0.108 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.01414 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.005182 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.002681 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.00457 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.01797 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.002077 Informative Inherited
Biological Process (BP) response to lipid 0.9858 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.8066 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.01749 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.2395 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.002808 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) protein transport 0.004436 Informative Inherited
Biological Process (BP) organ morphogenesis 0.004945 Informative Inherited
Biological Process (BP) sensory organ development 0.002214 Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0000000000001143 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 0.000000000000173 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.00000006765 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0000002966 Highly Informative Direct
Biological Process (BP) female pregnancy 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0 Highly Informative Direct
Biological Process (BP) lactation 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.00000000000006861 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.0000000000002698 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.0000000000003292 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00000000006123 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0000000004453 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.000000000784 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.000000001923 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.000000003203 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.00000002436 Highly Informative Direct
Biological Process (BP) renal system development 0.00000002908 Highly Informative Direct
Biological Process (BP) gonad development 0.00000005251 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00000006162 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.00000006559 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0000001313 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.0000001433 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.000000157 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0000002451 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0000002888 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000003448 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000006193 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000001005 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.000001297 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0.000001921 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.00000222 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.000003311 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.000003853 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.00002146 Highly Informative Direct
Biological Process (BP) positive regulation of cell killing 0.00002798 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.00004554 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.00005397 Highly Informative Direct
Biological Process (BP) nuclear import 0.00007332 Highly Informative Direct
Biological Process (BP) innate immune response 0.0001111 Highly Informative Direct
Biological Process (BP) protein import 0.0003479 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.0009833 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.00379 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.003067 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.01857 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.3831 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.09203 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.001218 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.8053 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.04988 Highly Informative Inherited
Biological Process (BP) stem cell development 0.0177 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.002046 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated immunity 0.1056 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated cytotoxicity 0.2122 Highly Informative Inherited
Molecular Function (MF) binding 0.0000004117 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000000002868 Informative Direct
Molecular Function (MF) enzyme binding 0.0000002444 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0000002963 Informative Direct
Molecular Function (MF) receptor binding 0.0431 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.0000000005245 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.0000000002355 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.0000867 Highly Informative Direct
Molecular Function (MF) kinase binding 0.03528 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.7945 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.000000006004 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.3343 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.5352 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.001191 Informative Inherited
Cellular Component (CC) dendrite 0.00000661 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.04545Least InformativeInherited
Disease Ontology (DO)organ system cancer0.08609Least InformativeInherited
Disease Ontology (DO)lung disease0.00007835Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001709Moderately InformativeInherited
Disease Ontology (DO)leukemia0.009882Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7537Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000001365InformativeDirect
Disease Ontology (DO)chronic leukemia0.00008532InformativeDirect
Disease Ontology (DO)glomerulonephritis0.0001093InformativeDirect
Disease Ontology (DO)myeloid leukemia0.1352InformativeInherited
Disease Ontology (DO)viral infectious disease0.2718InformativeInherited
Disease Ontology (DO)mumps0.000000005273Highly InformativeDirect
Disease Ontology (DO)colitis0.000000187Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome0.00001148Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.01491Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07387Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1078Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.000009689Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0005677Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008371Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.002498Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01304Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.03103Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.03508Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03692Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.03712Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.03817Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2595Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.3138Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3248Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin level0.00000000775InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0000000128InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion0.0000002437InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.000007418InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0001674InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.0003954InformativeDirect
Mammalian Phenotype (MP)abnormal circulating leptin level0.0004211InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0005086InformativeDirect
Mammalian Phenotype (MP)abnormal respiration0.0009311InformativeDirect
Mammalian Phenotype (MP)abnormal antigen presentation0.0009545InformativeDirect
Mammalian Phenotype (MP)abnormal circulating triglyceride level0.0009948InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.001819InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.002542InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.007927InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.008258InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05181InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.0533InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.06103InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1444InformativeInherited
Mammalian Phenotype (MP)abnormal total tissue mass0.1567InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2299InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology0.3105InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.4425InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.4499InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.6482InformativeInherited
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0000003066Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion0.000001828Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.000002376Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.000004788Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.00000746Highly InformativeDirect
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.00001131Highly InformativeDirect
Mammalian Phenotype (MP)enlarged liver0.00002189Highly InformativeDirect
Mammalian Phenotype (MP)abnormal corpus luteum morphology0.00003739Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level0.00005784Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.0001126Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.0001422Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreas secretion0.0001862Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell physiology0.0002006Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0003045Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor incidence0.0003527Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive T cell differentiation0.0003767Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.0004692Highly InformativeDirect
Mammalian Phenotype (MP)impaired glucose tolerance0.0006985Highly InformativeDirect
Mammalian Phenotype (MP)increased body weight0.0009697Highly InformativeDirect
Mammalian Phenotype (MP)abnormal food intake0.002775Highly InformativeInherited
Mammalian Phenotype (MP)abnormal body fat mass0.003345Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus size0.04693Highly InformativeInherited

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainSH2 domain0InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00001352Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013799 SSF48092 Protein matches
Abstract

This entry represents the N-terminal domain, which is responsible for protein interactions. This domain has a multi-helical structure that can be subdivided into two structural sub-domains.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transcription factor STAT-4 N-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Transcription factor STAT-4 N-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]