SUPERFAMILY 1.75 HMM library and genome assignments server

Transcription factor STAT-4 N-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transcription factor STAT-4 N-domain [ 48091]
Superfamily:   Transcription factor STAT-4 N-domain [ 48092]
Families:   Transcription factor STAT-4 N-domain [ 48093]


Superfamily statistics
Genomes (120) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 629 955 1
Proteins 629 952 1


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)single-organism cellular process00.00000000009382Least InformativeDirect
Biological Process (BP)positive regulation of biological process00.0000000001193Least InformativeDirect
Biological Process (BP)regulation of metabolic process00.0000005555Least InformativeDirect
Biological Process (BP)regulation of developmental process00Moderately InformativeDirect
Biological Process (BP)organ development00Moderately InformativeDirect
Biological Process (BP)cell differentiation00Moderately InformativeDirect
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process00Moderately InformativeDirect
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00.0000000000001788Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process00.0000000000003084Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process00.00000000002726Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process00.000002101Moderately InformativeDirect
Biological Process (BP)tissue development00.000503Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis00.5216Moderately InformativeInherited
Biological Process (BP)positive regulation of gene expression00InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)positive regulation of RNA metabolic process00InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process00InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process00InformativeDirect
Biological Process (BP)regulation of cell activation00.000000005101InformativeDirect
Biological Process (BP)regulation of transcription from RNA polymerase II promoter00.00000001483InformativeDirect
Biological Process (BP)gland development00.00000009931InformativeDirect
Biological Process (BP)negative regulation of immune system process00.0000001518InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development00.000000328InformativeDirect
Biological Process (BP)leukocyte activation00.0005295InformativeDirect
Biological Process (BP)positive regulation of immune system process00.0005456InformativeDirect
Biological Process (BP)epithelium development01InformativeInherited
Biological Process (BP)regulation of immune effector process00.01496InformativeInherited
Biological Process (BP)positive regulation of lymphocyte mediated immunity00.000000000000009016Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-templated00.0000000000005723Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation00.00000002568Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development00.000001336Highly InformativeDirect
Molecular Function (MF)binding00.0000005564Least InformativeDirect
Molecular Function (MF)nucleic acid binding00Moderately InformativeDirect
Molecular Function (MF)DNA binding00InformativeDirect
Molecular Function (MF)transcription regulatory region DNA binding00.0000000008147Highly InformativeDirect
Molecular Function (MF)sequence-specific DNA binding00.00004682Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000009382 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.0000000001193 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0000005555 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00009101 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0006133 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.01341 Least Informative Inherited
Biological Process (BP) localization 0.004263 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.1608 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.0127 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.001882 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.01094 Least Informative Inherited
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000000000001788 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0000000000003084 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00000000002726 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000002101 Moderately Informative Direct
Biological Process (BP) tissue development 0.000503 Moderately Informative Direct
Biological Process (BP) reproductive process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000000000000009016 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000000000006101 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00000000002177 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.00000000002816 Moderately Informative Direct
Biological Process (BP) gene expression 0.0000000003422 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.000000007234 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00000002192 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000002948 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000001283 Moderately Informative Direct
Biological Process (BP) defense response 0.0000001559 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0005263 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.01459 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.1061 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.6528 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.8082 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5216 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02791 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.04311 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.9215 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8444 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.00823 Moderately Informative Inherited
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) regulation of cell activation 0.000000005101 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.00000001483 Informative Direct
Biological Process (BP) gland development 0.00000009931 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0000001518 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.000000328 Informative Direct
Biological Process (BP) leukocyte activation 0.0005295 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0005456 Informative Direct
Biological Process (BP) cell proliferation 0 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) response to nutrient levels 0 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.000000000000003707 Informative Direct
Biological Process (BP) apoptotic process 0.000000000000003707 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0000000000005824 Informative Direct
Biological Process (BP) regulation of defense response 0.0000000000009053 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.00000000002223 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.00000000004267 Informative Direct
Biological Process (BP) protein maturation 0.00000000004811 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0000000003373 Informative Direct
Biological Process (BP) regulation of growth 0.0000000004383 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.00000002558 Informative Direct
Biological Process (BP) lipid localization 0.00000002817 Informative Direct
Biological Process (BP) phosphorylation 0.00000004413 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00000005039 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00000005069 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00000009983 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000004132 Informative Direct
Biological Process (BP) generation of neurons 0.0000006444 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0000008634 Informative Direct
Biological Process (BP) regulation of response to wounding 0.00000204 Informative Direct
Biological Process (BP) immune response 0.000002042 Informative Direct
Biological Process (BP) response to bacterium 0.000004854 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000007726 Informative Direct
Biological Process (BP) sensory organ development 0.0004794 Informative Direct
Biological Process (BP) protein localization to organelle 0.0005018 Informative Direct
Biological Process (BP) organ morphogenesis 0.0007573 Informative Direct
Biological Process (BP) positive regulation of cell death 0.0007877 Informative Direct
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.112 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.04528 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.002504 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.5981 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.0151 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1306 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.2098 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.002092 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.3546 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.01701 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.008316 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.1349 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.005089 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.03275 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.006215 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.03753 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01034 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.01172 Informative Inherited
Biological Process (BP) response to lipid 0.997 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.6162 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.01812 Informative Inherited
Biological Process (BP) reproductive structure development 0.0181 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01861 Informative Inherited
Biological Process (BP) protein transport 0.004527 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.8248 Informative Inherited
Biological Process (BP) regulation of immune response 0.1043 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.01496 Informative Inherited
Biological Process (BP) positive regulation of lymphocyte mediated immunity 0.000000000000009016 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.0000000000005723 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.00000002568 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.000001336 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0 Highly Informative Direct
Biological Process (BP) body fluid secretion 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) zymogen activation 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0 Highly Informative Direct
Biological Process (BP) secretion by tissue 0.000000000000003707 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0000000000003128 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.0000000000004372 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.0000000000008216 Highly Informative Direct
Biological Process (BP) maintenance of location 0.000000000001101 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.000000000005631 Highly Informative Direct
Biological Process (BP) kidney development 0.00000000003291 Highly Informative Direct
Biological Process (BP) positive regulation of response to wounding 0.00000000005058 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00000000006097 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.000000000441 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0000000005692 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.000000003257 Highly Informative Direct
Biological Process (BP) gonad development 0.000000008891 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.00000002219 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00000005442 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00000007141 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.0000001668 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000002082 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0000002095 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0000003026 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000006315 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.000000639 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.0000009152 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.000001023 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000001064 Highly Informative Direct
Biological Process (BP) female pregnancy 0.00000223 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.000003687 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.00003055 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.00006488 Highly Informative Direct
Biological Process (BP) innate immune response 0.0002005 Highly Informative Direct
Biological Process (BP) protein import 0.0005381 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.7347 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.002539 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.003739 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.001214 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.01775 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.387 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated cytotoxicity 0.1887 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.001449 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.001276 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.05016 Highly Informative Inherited
Biological Process (BP) stem cell development 0.01511 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1396 Highly Informative Inherited
Molecular Function (MF) binding 0.0000005564 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000000002781 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0000002118 Informative Direct
Molecular Function (MF) enzyme binding 0.0000002694 Informative Direct
Molecular Function (MF) receptor binding 0.04266 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.0000000008147 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.00004682 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.0000000002489 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.00008598 Highly Informative Direct
Molecular Function (MF) kinase binding 0.03569 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.8043 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0000000008435 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.1809 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.5735 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.001295 Informative Inherited
Cellular Component (CC) dendrite 0.000005942 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.04628Least InformativeInherited
Disease Ontology (DO)organ system cancer0.08676Least InformativeInherited
Disease Ontology (DO)obstructive lung disease0.00001501Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001737Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.01773Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7545Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000001373InformativeDirect
Disease Ontology (DO)glomerulonephritis0.0001088InformativeDirect
Disease Ontology (DO)myeloid leukemia0.135InformativeInherited
Disease Ontology (DO)viral infectious disease0.2717InformativeInherited
Disease Ontology (DO)mumps0.000000005262Highly InformativeDirect
Disease Ontology (DO)colitis0.0000001874Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome0.0000115Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.00001167Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.01516Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07681Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1089Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.000009695Moderately InformativeDirect
Mammalian Phenotype (MP)tumorigenesis0.0003461Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0005665Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008538Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.002536Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01363Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.03166Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.03587Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0368Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03793Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.03837Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2576Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.3101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3381Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin level0.000000007287InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.00000001245InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion0.0000002346InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.000007661InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0001714InformativeDirect
Mammalian Phenotype (MP)abnormal circulating leptin level0.0004218InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0004962InformativeDirect
Mammalian Phenotype (MP)abnormal antigen presentation0.0009244InformativeDirect
Mammalian Phenotype (MP)abnormal respiration0.0009703InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.001876InformativeInherited
Mammalian Phenotype (MP)abnormal female genitalia morphology0.002697InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.008275InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.008622InformativeInherited
Mammalian Phenotype (MP)abnormal cell proliferation0.02044InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05451InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.05562InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.06273InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1501InformativeInherited
Mammalian Phenotype (MP)abnormal total tissue mass0.1582InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2359InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology0.3039InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.4415InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.4539InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.6504InformativeInherited
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.0000001778Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0000003052Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion0.00000197Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.000002369Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.00000517Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.000006962Highly InformativeDirect
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.00001157Highly InformativeDirect
Mammalian Phenotype (MP)obese0.00002394Highly InformativeDirect
Mammalian Phenotype (MP)abnormal corpus luteum morphology0.00003776Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level0.00005598Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.0001204Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.0001566Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0003126Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor incidence0.0003536Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.00049Highly InformativeDirect
Mammalian Phenotype (MP)impaired glucose tolerance0.0007009Highly InformativeDirect
Mammalian Phenotype (MP)abnormal food intake0.002972Highly InformativeInherited
Mammalian Phenotype (MP)abnormal body fat mass0.003275Highly InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.0114Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus size0.04692Highly InformativeInherited
Mammalian Phenotype (MP)abnormal liver size0.08199Highly InformativeInherited

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainSH2 domain0InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00001418Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013799 SSF48092 Protein matches
Abstract

This entry represents the N-terminal domain, which is responsible for protein interactions. This domain has a multi-helical structure that can be subdivided into two structural sub-domains.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transcription factor STAT-4 N-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Transcription factor STAT-4 N-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]