SUPERFAMILY 1.75 HMM library and genome assignments server


DBL homology domain (DH-domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DBL homology domain (DH-domain) [ 48064]
Superfamily:   DBL homology domain (DH-domain) [ 48065]
Families:   DBL homology domain (DH-domain) [ 48066] (10)


Superfamily statistics
Genomes (393) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 10,976 12,001 16
Proteins 10,667 11,712 16


Functional annotation
General category coiled coil
Detailed category The code refers to a 2-stranded_canonical_antiparallel_coiled_coils in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process4.451e-082.331e-13Least InformativeDirect
Biological Process (BP)response to stimulus5.248e-050Least InformativeDirect
Biological Process (BP)multicellular organismal process0.0028370Least InformativeInherited
Biological Process (BP)developmental process0.001210Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0025850Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0038730Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.040680Least InformativeInherited
Biological Process (BP)regulation of signal transduction3.151e-120Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.02091Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.28890.0007838Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.30280.7527Moderately InformativeInherited
Biological Process (BP)system process0.026190.08732Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.01120Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death0.0001060.1367Moderately InformativeInherited
Biological Process (BP)regulation of localization0.023071Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.36740Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.10680Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.061320Moderately InformativeInherited
Biological Process (BP)organ development6.801e-060.7844Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.017434.729e-07Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)multi-organism process0.0025070.3983Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.048471Moderately InformativeInherited
Biological Process (BP)response to organic substance0.16270.2503Moderately InformativeInherited
Biological Process (BP)signal transduction0.046761.106e-06Moderately InformativeInherited
Biological Process (BP)organelle organization0.10450.00633Moderately InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process6.244e-110InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process2.806e-100InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity4.753e-100InformativeDirect
Biological Process (BP)cytoskeleton organization4.913e-050InformativeDirect
Biological Process (BP)positive regulation of cellular component organization0.0006536.242e-10InformativeDirect
Biological Process (BP)actin filament-based process0.00077430InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.4591InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.42051InformativeInherited
Biological Process (BP)regulation of cellular component movement0.0022350.8327InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.073841InformativeInherited
Biological Process (BP)negative regulation of cell death0.044460.9189InformativeInherited
Biological Process (BP)negative regulation of transport0.0029660.01347InformativeInherited
Biological Process (BP)regulation of secretion0.03670.2044InformativeInherited
Biological Process (BP)regulation of immune response0.26671InformativeInherited
Biological Process (BP)regulation of immune effector process4.342e-070.005967InformativeInherited
Biological Process (BP)sensory organ development2.89e-051InformativeInherited
Biological Process (BP)embryonic organ development0.00019211InformativeInherited
Biological Process (BP)embryonic morphogenesis0.00075180.01154InformativeInherited
Biological Process (BP)organ morphogenesis0.004913.914e-06InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.0013360InformativeInherited
Biological Process (BP)response to lipid2.223e-051InformativeInherited
Biological Process (BP)response to other organism0.00012321InformativeInherited
Biological Process (BP)regulation of defense response7.816e-060.3831InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.045941InformativeInherited
Biological Process (BP)regulation of locomotion0.0018660.04116InformativeInherited
Biological Process (BP)intracellular signal transduction0.012110InformativeInherited
Biological Process (BP)regulation of Rho GTPase activity2.97e-120Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction6.565e-090Highly InformativeDirect
Biological Process (BP)regulation of protein kinase B signaling cascade6.57e-099.7e-06Highly InformativeDirect
Biological Process (BP)regulation of exocytosis2.548e-082.022e-05Highly InformativeDirect
Biological Process (BP)negative regulation of secretion3.798e-082.373e-05Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus6.137e-082.795e-05Highly InformativeDirect
Biological Process (BP)negative regulation of neuron death7.626e-088.937e-05Highly InformativeDirect
Biological Process (BP)response to lipopolysaccharide2.121e-070.0003285Highly InformativeDirect
Biological Process (BP)negative regulation of cell activation6.577e-052.265e-05Highly InformativeDirect
Biological Process (BP)negative regulation of cellular component movement0.00019890.0004321Highly InformativeDirect
Biological Process (BP)neuromuscular process7.023e-090.08998Highly InformativeInherited
Biological Process (BP)regulation of endocytosis0.00020450.7811Highly InformativeInherited
Biological Process (BP)regulation of neuron apoptotic process3.013e-070.7199Highly InformativeInherited
Biological Process (BP)negative regulation of apoptotic process9.452e-061Highly InformativeInherited
Biological Process (BP)negative regulation of immune system process0.00040460.002778Highly InformativeInherited
Biological Process (BP)embryonic organ morphogenesis4.675e-081Highly InformativeInherited
Biological Process (BP)ear development0.017720.00101Highly InformativeInherited
Biological Process (BP)positive regulation of Ras GTPase activity0.016058.894e-12Highly InformativeInherited
Molecular Function (MF)enzyme regulator activity2.836e-120Moderately InformativeDirect
Molecular Function (MF)GTPase regulator activity9.935e-100InformativeDirect
Molecular Function (MF)enzyme activator activity0.00054041InformativeInherited
Molecular Function (MF)GTPase activator activity0.029461Highly InformativeInherited
Molecular Function (MF)small GTPase regulator activity0.042490.0001244Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.00043590.0001039Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.21621Least InformativeInherited
Cellular Component (CC)vesicle0.00082150.000761Moderately InformativeDirect
Cellular Component (CC)cell projection0.0010190Moderately InformativeInherited
Cellular Component (CC)cell leading edge2.294e-060InformativeDirect
Cellular Component (CC)endocytic vesicle8.935e-076.635e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 2.331e-13 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) localization 0.003684 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 4.729e-07 Moderately Informative Direct
Biological Process (BP) signal transduction 1.106e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) nervous system development 8.431e-07 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0007838 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1.18e-07 Moderately Informative Direct
Biological Process (BP) immune system process 2.328e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.7527 Moderately Informative Inherited
Biological Process (BP) system process 0.08732 Moderately Informative Inherited
Biological Process (BP) organ development 0.7844 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3805 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.1367 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2503 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01265 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.01796 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3983 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.00633 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.988 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9239 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2219 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 6.242e-10 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) organ morphogenesis 3.914e-06 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of cell development 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) cellular component movement 1.113e-12 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 2.159e-11 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 3.612e-11 Informative Direct
Biological Process (BP) regulation of anatomical structure size 2.669e-10 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 6.731e-10 Informative Direct
Biological Process (BP) synaptic transmission 5.703e-09 Informative Direct
Biological Process (BP) pigment metabolic process 4.558e-08 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.263e-06 Informative Direct
Biological Process (BP) secondary metabolic process 5.495e-05 Informative Direct
Biological Process (BP) generation of neurons 0.0001662 Informative Direct
Biological Process (BP) biological adhesion 0.0002236 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0005902 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.1621 Informative Inherited
Biological Process (BP) growth 0.186 Informative Inherited
Biological Process (BP) tube development 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) epithelium development 0.388 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2594 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.00219 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.8327 Informative Inherited
Biological Process (BP) organelle assembly 0.2638 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.3285 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.01818 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.02642 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.03528 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.05484 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of growth 0.5558 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.9189 Informative Inherited
Biological Process (BP) negative regulation of transport 0.01347 Informative Inherited
Biological Process (BP) regulation of secretion 0.2044 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.005967 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) immune response 0.01772 Informative Inherited
Biological Process (BP) defense response 0.05182 Informative Inherited
Biological Process (BP) immune effector process 0.009651 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.7952 Informative Inherited
Biological Process (BP) regulation of defense response 0.3831 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.9877 Informative Inherited
Biological Process (BP) regulation of locomotion 0.04116 Informative Inherited
Biological Process (BP) leukocyte activation 0.01043 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.3165 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.1113 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.1268 Informative Inherited
Biological Process (BP) central nervous system development 0.4485 Informative Inherited
Biological Process (BP) cellular membrane organization 0.631 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.01154 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7639 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9391 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.003252 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.438 Informative Inherited
Biological Process (BP) regulation of Rho GTPase activity 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 9.7e-06 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 2.022e-05 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 2.373e-05 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 2.795e-05 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 8.937e-05 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0003285 Highly Informative Direct
Biological Process (BP) negative regulation of cell activation 2.265e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0004321 Highly Informative Direct
Biological Process (BP) positive regulation of Ras GTPase activity 8.894e-12 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) chemotaxis 9.182e-15 Highly Informative Direct
Biological Process (BP) phagocytosis 3.475e-13 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 1.139e-11 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 3.521e-11 Highly Informative Direct
Biological Process (BP) T cell differentiation 1.165e-10 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1.343e-09 Highly Informative Direct
Biological Process (BP) limb morphogenesis 3.962e-09 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 5.743e-09 Highly Informative Direct
Biological Process (BP) leukocyte migration 1.175e-08 Highly Informative Direct
Biological Process (BP) cell projection assembly 1.391e-08 Highly Informative Direct
Biological Process (BP) post-embryonic development 1.94e-06 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 0.000435 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0005118 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0007329 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.00087 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 0.0009316 Highly Informative Direct
Biological Process (BP) cell growth 0.022 Highly Informative Inherited
Biological Process (BP) developmental growth 0.3949 Highly Informative Inherited
Biological Process (BP) renal system development 1 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.008861 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 0.6631 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.102 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.1982 Highly Informative Inherited
Biological Process (BP) spindle organization 0.0225 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.08998 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.7811 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.05939 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.007746 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.08879 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.005413 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.7199 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.002778 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) ear development 0.00101 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.3966 Highly Informative Inherited
Biological Process (BP) innate immune response 0.01015 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.01686 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.09274 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.343 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.08191 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.5639 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.9946 Highly Informative Inherited
Biological Process (BP) axon development 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.1856 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.6605 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) meiosis 0.1536 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.3899 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) cell division 0.00714 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Molecular Function (MF) binding 1.563e-15 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 4.099e-07 Moderately Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 2.847e-13 Informative Direct
Molecular Function (MF) enzyme binding 1.745e-09 Informative Direct
Molecular Function (MF) receptor binding 0.1765 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.135 Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.0001244 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 1 Highly Informative Inherited
Molecular Function (MF) Ras GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.004025 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0.05195 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0001039 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0005273 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.03183 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.000761 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytosol 2.291e-07 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1.536e-05 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.07793 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) synapse part 9.032e-05 Informative Direct
Cellular Component (CC) contractile fiber part 0.0001004 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.2699 Informative Inherited
Cellular Component (CC) endocytic vesicle 6.635e-06 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 1.207e-14 Highly Informative Direct
Cellular Component (CC) cell division site part 9.235e-14 Highly Informative Direct
Cellular Component (CC) cell body 0.0001592 Highly Informative Direct
Cellular Component (CC) growth cone 0.0003372 Highly Informative Direct
Cellular Component (CC) dendrite 0.006815 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.2942 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.3197Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4383Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.4848Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6545Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.06048Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.06907Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.1034Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.2745Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.453Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.6433Moderately InformativeInherited
Mammalian Phenotype (MP)decreased leukocyte cell number0.04087InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.04138InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1505InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.4405InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.6559InformativeInherited
Mammalian Phenotype (MP)abnormal vascular endothelial cell development0.005355Highly InformativeInherited
Mammalian Phenotype (MP)abnormal iris morphology0.01366Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immature B cell morphology0.3076Highly InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.8296Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pharyngeal pumping variant0.0003694Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation7.643e-09Moderately InformativeDirect
Biological processCell cycle4.986e-06Moderately InformativeDirect
Biological processNeurogenesis3.923e-11InformativeDirect
Biological processEndocytosis3.129e-06InformativeDirect
Biological processInnate immunity2.763e-05InformativeDirect
Biological processSeptation0.0007421Highly InformativeDirect
Cellular componentCytoplasm1.367e-09Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentGolgi apparatus2.55e-05Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0001527Moderately InformativeDirect
Cellular componentEndosome0.0006163Moderately InformativeDirect
Cellular componentMicrotubule0.0003373InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentSynaptosome0.0001066Highly InformativeDirect
Coding sequence diversityAlternative splicing9.042e-08Least InformativeDirect
DiseaseProto-oncogene3.794e-12Moderately InformativeDirect
DomainRepeat1.496e-11Least InformativeDirect
DomainCoiled coil3.104e-16Moderately InformativeDirect
DomainZinc-finger1.348e-06Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH2 domain5.741e-11InformativeDirect
DomainImmunoglobulin domain0.0009659InformativeDirect
Molecular functionZinc3.717e-05Least InformativeDirect
Molecular functionCalmodulin-binding5.53e-07InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein2.999e-06Moderately InformativeDirect
Post-translational modificationKinase0.08166Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase5.766e-08InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMyristate0.0001073InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000219 SSF48065 Protein matches
Abstract

The Rho family GTPases Rho, Rac and CDC42 regulate a diverse array of cellular processes. Like all members of the Ras superfamily, the Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states. Activation of Rho proteins through release of bound GDP and subsequent binding of GTP, is catalyzed by guanine nucleotide exchange factors (GEFs) in the Dbl family. The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. In addition, all family members possess a second, shared domain designated the pleckstrin homology (PH) domain . Trio and its homolog UNC-73 are unique within the Dbl family insomuch as they encode two distinct DH/PH domain modules. The PH domain is invariably located immediately C-terminal to the DH domain and this invariant topography suggests a functional interdependence between these two structural modules. Biochemical data have established the role of the conserved DH domain in Rho GTPase interaction and activation, and the role of the tandem PH domain in intracellular targeting and/or regulation of DH domain function. The DH domain of Dbl has been shown to mediate oligomerization that is mostly homophilic in nature. In addition to the tandem DH/PH domains Dbl family GEFs contain diverse structural motifs like serine/threonine kinase, RBD, PDZ, RGS, IQ, REM, Cdc25 RasGEF, CH, SH2, SH3, EF, spectrin or Ig.

The DH domain is composed of three structurally conserved regions separated by more variable regions. It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. The DH domain is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH junction site, constitute the Rho GTPase interacting pocket.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DBL homology domain (DH-domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the DBL homology domain (DH-domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]