SUPERFAMILY 1.75 HMM library and genome assignments server


DBL homology domain (DH-domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DBL homology domain (DH-domain) [ 48064]
Superfamily:   DBL homology domain (DH-domain) [ 48065]
Families:   DBL homology domain (DH-domain) [ 48066] (10)


Superfamily statistics
Genomes (389) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 10,484 0 16
Proteins 10,191 0 16


Functional annotation
General category coiled coil
Detailed category The code refers to a 2-stranded_canonical_antiparallel_coiled_coils in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process2.499e-073.151e-13Least InformativeDirect
Biological Process (BP)response to stimulus0.00017360Least InformativeDirect
Biological Process (BP)developmental process0.0049670Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0054261.922e-15Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0072850Least InformativeInherited
Biological Process (BP)regulation of signal transduction7.035e-110Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.044941Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.19230.0009047Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.20880.7361Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.4920Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.19670Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.099920Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)signal transduction0.022681.404e-06Moderately InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process4.902e-090InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process1.739e-080InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity2.65e-080InformativeDirect
Biological Process (BP)regulation of apoptotic process4.749e-050InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.32331InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.28961InformativeInherited
Biological Process (BP)negative regulation of cell death0.018760.8979InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.0051890InformativeInherited
Biological Process (BP)intracellular signal transduction0.012160InformativeInherited
Biological Process (BP)regulation of Rho GTPase activity9.306e-100Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction3.541e-090Highly InformativeDirect
Biological Process (BP)regulation of protein kinase B signaling cascade4.122e-099.005e-06Highly InformativeDirect
Biological Process (BP)negative regulation of neuron death4.466e-088.599e-05Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process1.865e-070.7115Highly InformativeInherited
Biological Process (BP)negative regulation of apoptotic process5.669e-061Highly InformativeInherited
Biological Process (BP)positive regulation of Ras GTPase activity0.036945.061e-11Highly InformativeInherited
Molecular Function (MF)enzyme regulator activity1.019e-100Moderately InformativeDirect
Molecular Function (MF)GTPase regulator activity9.668e-080InformativeDirect
Cellular Component (CC)cytoplasmic part0.0013590.0001212Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.15951Least InformativeInherited
Cellular Component (CC)vesicle0.00045910.0003221Moderately InformativeDirect
Cellular Component (CC)cell projection0.00052070Moderately InformativeDirect
Cellular Component (CC)cell leading edge1.135e-060InformativeDirect
Cellular Component (CC)endocytic vesicle5.697e-076.006e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 3.151e-13 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1.922e-15 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) localization 0.002106 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) signal transduction 1.404e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 5.35e-07 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 2.511e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0009047 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 2.05e-07 Moderately Informative Direct
Biological Process (BP) nervous system development 4.978e-07 Moderately Informative Direct
Biological Process (BP) immune system process 1.291e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.7361 Moderately Informative Inherited
Biological Process (BP) system process 0.09277 Moderately Informative Inherited
Biological Process (BP) organ development 0.8627 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3657 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2451 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.009499 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.01625 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.4176 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.007495 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9623 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.913 Moderately Informative Inherited
Biological Process (BP) reproduction 0.18 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 3.032e-09 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of cell development 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) cellular component movement 1.017e-12 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 1.279e-11 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 1.041e-10 Informative Direct
Biological Process (BP) regulation of anatomical structure size 2.72e-10 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 6e-10 Informative Direct
Biological Process (BP) pigment metabolic process 3.715e-08 Informative Direct
Biological Process (BP) cellular component morphogenesis 7.123e-07 Informative Direct
Biological Process (BP) organ morphogenesis 1.034e-05 Informative Direct
Biological Process (BP) secondary metabolic process 4.734e-05 Informative Direct
Biological Process (BP) generation of neurons 0.0001842 Informative Direct
Biological Process (BP) biological adhesion 0.0004013 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0006025 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.1503 Informative Inherited
Biological Process (BP) programmed cell death 0.17 Informative Inherited
Biological Process (BP) growth 0.07245 Informative Inherited
Biological Process (BP) tube development 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) epithelium development 0.315 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3308 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.001919 Informative Inherited
Biological Process (BP) organelle assembly 0.1929 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.3899 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.01515 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.02271 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.03032 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.04799 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of growth 0.5495 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.8979 Informative Inherited
Biological Process (BP) regulation of secretion 0.285 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.01665 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) immune response 0.01624 Informative Inherited
Biological Process (BP) defense response 0.04412 Informative Inherited
Biological Process (BP) immune effector process 0.009792 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.7219 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.9579 Informative Inherited
Biological Process (BP) leukocyte activation 0.01035 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.2816 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.09989 Informative Inherited
Biological Process (BP) central nervous system development 0.4881 Informative Inherited
Biological Process (BP) cellular membrane organization 0.6117 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.01406 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6979 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cell-cell signaling 0.1454 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.00118 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9357 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.002794 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.4349 Informative Inherited
Biological Process (BP) regulation of Rho GTPase activity 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 9.005e-06 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 8.599e-05 Highly Informative Direct
Biological Process (BP) positive regulation of Ras GTPase activity 5.061e-11 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) chemotaxis 7.281e-15 Highly Informative Direct
Biological Process (BP) phagocytosis 2.096e-13 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 6.952e-12 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 2.806e-11 Highly Informative Direct
Biological Process (BP) T cell differentiation 7.655e-11 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 3.605e-09 Highly Informative Direct
Biological Process (BP) limb morphogenesis 4.292e-09 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 7.404e-09 Highly Informative Direct
Biological Process (BP) cell projection assembly 1.03e-08 Highly Informative Direct
Biological Process (BP) leukocyte migration 1.184e-08 Highly Informative Direct
Biological Process (BP) post-embryonic development 9.698e-07 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 0.0001358 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.0001578 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0003583 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 0.0003838 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0006596 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0006741 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 0.0007973 Highly Informative Direct
Biological Process (BP) cell growth 0.02177 Highly Informative Inherited
Biological Process (BP) developmental growth 0.3874 Highly Informative Inherited
Biological Process (BP) renal system development 1 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.008391 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 0.6571 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.08694 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.1845 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.1507 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.07305 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.006495 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.09333 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.009013 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.7115 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.008769 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.3792 Highly Informative Inherited
Biological Process (BP) innate immune response 0.009908 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.01619 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.07944 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.3369 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.06978 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.5438 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.983 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.12 Highly Informative Inherited
Biological Process (BP) axon development 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.1842 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.6333 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) meiosis 0.1533 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.3922 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) cell division 0.006598 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 4.114e-07 Moderately Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 3.154e-13 Informative Direct
Molecular Function (MF) enzyme binding 9.296e-10 Informative Direct
Molecular Function (MF) receptor binding 0.1804 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.1293 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0001473 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.004274 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0.05224 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0001212 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0006187 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.01716 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.0003221 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytosol 1.414e-07 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 8.004e-06 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.06257 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) synapse part 6.904e-05 Informative Direct
Cellular Component (CC) contractile fiber part 0.000267 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.2599 Informative Inherited
Cellular Component (CC) endocytic vesicle 6.006e-06 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 1.206e-14 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 1.206e-14 Highly Informative Direct
Cellular Component (CC) cell division site part 8.658e-14 Highly Informative Direct
Cellular Component (CC) contractile ring 1.444e-10 Highly Informative Direct
Cellular Component (CC) cell body 0.0001605 Highly Informative Direct
Cellular Component (CC) growth cone 0.0003436 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0.0005935 Highly Informative Direct
Cellular Component (CC) dendrite 0.0064 Highly Informative Inherited
Cellular Component (CC) sarcomere 1 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.2975 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.3189Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4418Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.4861Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6521Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.06051Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.06911Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.1035Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.2749Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.4591Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.645Moderately InformativeInherited
Mammalian Phenotype (MP)decreased leukocyte cell number0.04104InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.04169InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1493InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3027InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.4384InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.6496InformativeInherited
Mammalian Phenotype (MP)abnormal vascular endothelial cell development0.005368Highly InformativeInherited
Mammalian Phenotype (MP)abnormal iris morphology0.0138Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immature B cell morphology0.3086Highly InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.826Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pharyngeal pumping variant0.0003694Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation7.738e-09Moderately InformativeDirect
Biological processCell cycle5.064e-06Moderately InformativeDirect
Biological processNeurogenesis3.985e-11InformativeDirect
Biological processEndocytosis3.154e-06InformativeDirect
Biological processInnate immunity2.788e-05InformativeDirect
Biological processSeptation0.000743Highly InformativeDirect
Cellular componentCytoplasm1.459e-09Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentGolgi apparatus2.584e-05Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0001543Moderately InformativeDirect
Cellular componentEndosome0.000621Moderately InformativeDirect
Cellular componentMicrotubule0.0003402InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentSynaptosome0.0001067Highly InformativeDirect
Coding sequence diversityAlternative splicing9.079e-08Least InformativeDirect
DiseaseProto-oncogene3.794e-12Moderately InformativeDirect
DomainRepeat1.551e-11Least InformativeDirect
DomainCoiled coil3.093e-16Moderately InformativeDirect
DomainZinc-finger1.403e-06Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH2 domain5.849e-11InformativeDirect
DomainImmunoglobulin domain0.0009774InformativeDirect
Molecular functionZinc3.772e-05Least InformativeDirect
Molecular functionCalmodulin-binding5.596e-07InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein3.051e-06Moderately InformativeDirect
Post-translational modificationKinase0.08185Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase5.733e-08InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMyristate0.0001079InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000219 SSF48065 Protein matches
Abstract

The Rho family GTPases Rho, Rac and CDC42 regulate a diverse array of cellular processes. Like all members of the Ras superfamily, the Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states. Activation of Rho proteins through release of bound GDP and subsequent binding of GTP, is catalyzed by guanine nucleotide exchange factors (GEFs) in the Dbl family. The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. In addition, all family members possess a second, shared domain designated the pleckstrin homology (PH) domain . Trio and its homolog UNC-73 are unique within the Dbl family insomuch as they encode two distinct DH/PH domain modules. The PH domain is invariably located immediately C-terminal to the DH domain and this invariant topography suggests a functional interdependence between these two structural modules. Biochemical data have established the role of the conserved DH domain in Rho GTPase interaction and activation, and the role of the tandem PH domain in intracellular targeting and/or regulation of DH domain function. The DH domain of Dbl has been shown to mediate oligomerization that is mostly homophilic in nature. In addition to the tandem DH/PH domains Dbl family GEFs contain diverse structural motifs like serine/threonine kinase, RBD, PDZ, RGS, IQ, REM, Cdc25 RasGEF, CH, SH2, SH3, EF, spectrin or Ig.

The DH domain is composed of three structurally conserved regions separated by more variable regions. It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. The DH domain is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH junction site, constitute the Rho GTPase interacting pocket.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DBL homology domain (DH-domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the DBL homology domain (DH-domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]