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Guanido kinase N-terminal domain superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Metabolism |
| Detailed category | Transferases |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR000749 SSF48034 Protein matches |
| Abstract | ATP:guanido phosphotransferases are a family of structurally and functionally related enzymes
[ 2324092, 7819288] that reversibly catalyze the transfer of phosphate between
ATP and various phosphogens. The enzymes belonging to this family include glycocyamine kinase
, which catalyzes the transfer of phosphate from ATP to guanidoacetate; arginine
kinase , which catalyzes the transfer of phosphate from ATP to arginine; taurocyamine
kinase , an annelid-specific enzyme that catalyzes the transfer of phosphate from ATP
to taurocyamine; lombricine kinase , an annelid-specific enzyme that catalyzes the
transfer of phosphate from ATP to lombricine; Smc74, a cercaria-specific enzyme from Schistosoma
mansoni [2324092]; and creatine kinase (CK) [3896131, 2324105], which plays an important role in energy metabolism of vertebrates. It catalyzes the
reversible transfer of high energy phosphate from ATP to creatine, generating phosphocreatine and
ADP. There are at least four different, but very closely related, forms of CK. Two isozymes, M
(muscle) and B (brain), are cytosolic, while the other two are mitochondrial. In sea urchins there
is a flagellar isozyme, which consists of the triplication of a CK-domain. A cysteine residue is
implicated in the catalytic activity of these enzymes and the region around this active site residue
is highly conserved. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 8 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Guanido kinase N-terminal domain domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 8 hidden Markov models representing the Guanido kinase N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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