SUPERFAMILY 1.75 HMM library and genome assignments server


DEATH domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DEATH domain [ 47985]
Superfamily:   DEATH domain [ 47986] (4)
Families:   DEATH domain, DD [ 81312] (8)
  DEATH effector domain, DED [ 81388] (2)
  Caspase recruitment domain, CARD [ 81313] (5)
  Pyrin domain, PYD [ 101298] (2)


Superfamily statistics
Genomes (137) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,487 9,865 25
Proteins 8,371 8,797 25


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.00000061930Least InformativeDirect
Biological Process (BP)regulation of cellular process0.00000063280.00005091Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000020980Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.82511Least InformativeInherited
Biological Process (BP)positive regulation of cellular process0.000000000084560Moderately InformativeDirect
Biological Process (BP)regulation of localization0.000029480.0000000000682Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.000088180.0000000007804Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00028960.0000006576Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process0.0011551Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0012730.04804Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0012630.002916Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.000041391Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.17160Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production0.000000000000015710InformativeDirect
Biological Process (BP)regulation of establishment of protein localization0.0000000005520InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.00000026740InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0000018120.0005035InformativeDirect
Biological Process (BP)defense response0.000034680InformativeDirect
Biological Process (BP)positive regulation of transport0.000056490.005757InformativeInherited
Biological Process (BP)regulation of secretion0.025090.0807InformativeInherited
Biological Process (BP)positive regulation of cytokine production00Highly InformativeDirect
Biological Process (BP)regulation of interleukin-1 beta production0.000000000000012670Highly InformativeDirect
Biological Process (BP)positive regulation of protein secretion0.0000025540.00000000000008236Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion0.0032160.001641Highly InformativeInherited
Molecular Function (MF)binding0.00024890Least InformativeDirect
Molecular Function (MF)nucleic acid binding0.000091331Moderately InformativeInherited
Molecular Function (MF)DNA binding0.0000061880.461InformativeInherited
Molecular Function (MF)structure-specific DNA binding0.000000028690.04475Highly InformativeInherited
Cellular Component (CC)protein complex0.00022810Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00005091 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0000004207 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0000000000682 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000000007804 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000006576 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0000000000003709 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.00000000004665 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.000000007773 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.000000227 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000003782 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.00005243 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0008641 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.02167 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.07565 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.3996 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.04804 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.002916 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1171 Moderately Informative Inherited
Biological Process (BP) organ development 0.7518 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.01082 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.01307 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.05714 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.3656 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.02724 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.9151 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.0017 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.9405 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.08073 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.0005035 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0003008 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) response to other organism 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) protein complex assembly 0.00000000000003095 Informative Direct
Biological Process (BP) locomotion 0.000000000000129 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.000000000007896 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.0000000002717 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000000006221 Informative Direct
Biological Process (BP) regulation of response to stress 0.000000006384 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00000002424 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0000002105 Informative Direct
Biological Process (BP) regulation of locomotion 0.0000002529 Informative Direct
Biological Process (BP) cell projection organization 0.0000003088 Informative Direct
Biological Process (BP) protein transport 0.000001493 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000003095 Informative Direct
Biological Process (BP) blood circulation 0.000006725 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00002381 Informative Direct
Biological Process (BP) muscle system process 0.00004683 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0001324 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0.0001463 Informative Direct
Biological Process (BP) proteolysis 0.0001609 Informative Direct
Biological Process (BP) regulation of immune effector process 0.0005738 Informative Direct
Biological Process (BP) muscle structure development 0.0008924 Informative Direct
Biological Process (BP) regulation of nervous system development 0.1468 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) programmed cell death 0.02039 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.07015 Informative Inherited
Biological Process (BP) cellular membrane organization 0.1828 Informative Inherited
Biological Process (BP) tube development 0.3062 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.904 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.01621 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.074 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.8057 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.002543 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.00998 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.005757 Informative Inherited
Biological Process (BP) regulation of secretion 0.0807 Informative Inherited
Biological Process (BP) muscle tissue development 0.002686 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) phosphorylation 0.06839 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.2475 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.04021 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.9788 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.5779 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.04829 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.322 Informative Inherited
Biological Process (BP) cellular component movement 0.01511 Informative Inherited
Biological Process (BP) localization of cell 0.7388 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.2559 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.7977 Informative Inherited
Biological Process (BP) regulation of ion transport 0.8673 Informative Inherited
Biological Process (BP) response to nutrient levels 0.3883 Informative Inherited
Biological Process (BP) response to lipid 0.005787 Informative Inherited
Biological Process (BP) leukocyte activation 0.4369 Informative Inherited
Biological Process (BP) response to light stimulus 0.1797 Informative Inherited
Biological Process (BP) secretion by cell 0.9691 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.247 Informative Inherited
Biological Process (BP) regulation of cell development 0.02099 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.4642 Informative Inherited
Biological Process (BP) regulation of growth 0.2469 Informative Inherited
Biological Process (BP) single-organism behavior 0.01666 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.09277 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.9978 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.4687 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.01634 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.00000000000008236 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) execution phase of apoptosis 0 Highly Informative Direct
Biological Process (BP) activation of immune response 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 0 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.000000000000001922 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.00000000000001077 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0.00000000000001761 Highly Informative Direct
Biological Process (BP) heart contraction 0.0000000000002603 Highly Informative Direct
Biological Process (BP) striated muscle contraction 0.000000000001117 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.000000000002874 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.000000001691 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.00000000196 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.000000008251 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.00000001166 Highly Informative Direct
Biological Process (BP) axon development 0.00000001401 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.00000002447 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 0.00000007208 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.0000002487 Highly Informative Direct
Biological Process (BP) hair follicle development 0.0000003697 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0000006729 Highly Informative Direct
Biological Process (BP) defense response to bacterium 0.0000009257 Highly Informative Direct
Biological Process (BP) learning or memory 0.000001084 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000001431 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 0.00000327 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0.000006209 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.000008248 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response 0.00001205 Highly Informative Direct
Biological Process (BP) myeloid cell development 0.00001783 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte mediated immunity 0.00002512 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte migration 0.0000614 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.0001315 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0.0001604 Highly Informative Direct
Biological Process (BP) response to UV 0.0001814 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0003843 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0004062 Highly Informative Direct
Biological Process (BP) T cell differentiation 0.0004394 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.000632 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.0006338 Highly Informative Direct
Biological Process (BP) epithelial tube formation 0.0008885 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.3736 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.204 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.7013 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0.154 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.001456 Highly Informative Inherited
Biological Process (BP) sensory perception 0.00512 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.001083 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.001641 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.015 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.004313 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02459 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.01311 Highly Informative Inherited
Biological Process (BP) placenta development 0.09906 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.7907 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.5243 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.02199 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.2458 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.2099 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.9468 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.4139 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.003097 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.9107 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.02725 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.06509 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.9575 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.07275 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.2763 Highly Informative Inherited
Biological Process (BP) icosanoid metabolic process 0.001376 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.004024 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.01177 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.2202 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.1294 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.4339 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.002177 Highly Informative Inherited
Biological Process (BP) response to fungus 0.7038 Highly Informative Inherited
Biological Process (BP) innate immune response 0.01522 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.02053 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.001511 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0004984 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.001998 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.000000000004751 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.000006814 Informative Direct
Molecular Function (MF) receptor activity 0.00001554 Informative Direct
Molecular Function (MF) molecular transducer activity 0.00001687 Informative Direct
Molecular Function (MF) kinase activity 0.000124 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0002597 Informative Direct
Molecular Function (MF) enzyme binding 0.0003508 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.4016 Informative Inherited
Molecular Function (MF) amide binding 0.009309 Informative Inherited
Molecular Function (MF) receptor binding 0.432 Informative Inherited
Molecular Function (MF) DNA binding 0.461 Informative Inherited
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.000000000006313 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.00000000009561 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 0.0000000002407 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0000000004313 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.000005048 Highly Informative Direct
Molecular Function (MF) peptide binding 0.000009097 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.00002482 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.8895 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.2197 Highly Informative Inherited
Molecular Function (MF) protein binding transcription factor activity 0.1209 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 0.04475 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0002517 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.02384 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.000000000001437 Moderately Informative Direct
Cellular Component (CC) cytosol 0.000000000002208 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000002276 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.03958 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.000000003056 Informative Direct
Cellular Component (CC) cell-cell junction 0.00000002119 Informative Direct
Cellular Component (CC) synapse part 0.0000004515 Informative Direct
Cellular Component (CC) contractile fiber part 0.0000005875 Informative Direct
Cellular Component (CC) integral to membrane 0.8165 Informative Inherited
Cellular Component (CC) cell cortex 0.1087 Informative Inherited
Cellular Component (CC) cell-cell contact zone 0 Highly Informative Direct
Cellular Component (CC) membrane raft 0.0000000000003474 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0000002203 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.0003125 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0.0004037 Highly Informative Direct
Cellular Component (CC) main axon 0.002891 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.07211 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.05719 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.04479Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.003696Moderately InformativeInherited
Disease Ontology (DO)syndrome0.06003Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system disease0.06492Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.9819Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.0000008856InformativeDirect
Disease Ontology (DO)arthropathy0.03079InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.03084InformativeInherited
Disease Ontology (DO)viral infectious disease1InformativeInherited
Disease Ontology (DO)irritable bowel syndrome0.00006148Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.2985Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.4543Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.733Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.005083Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.009738Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.09299Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1786Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.6257Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.7191Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the spleen0.0001251InformativeDirect
Phenotypic Abnormality (PA)Visceromegaly0.001267InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.004759InformativeInherited
Phenotypic Abnormality (PA)Abnormality of leukocytes0.03596InformativeInherited
Phenotypic Abnormality (PA)Abnormality of humoral immunity0.1573InformativeInherited
Phenotypic Abnormality (PA)Vasculitis0.00000003225Highly InformativeDirect
Phenotypic Abnormality (PA)Lymphadenopathy0.0000004693Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.00000314Highly InformativeDirect
Phenotypic Abnormality (PA)Leukocytosis0.00001157Highly InformativeDirect
Phenotypic Abnormality (PA)Elevated erythrocyte sedimentation rate0.00003368Highly InformativeDirect
Phenotypic Abnormality (PA)Increased IgM level0.00008431Highly InformativeDirect
Phenotypic Abnormality (PA)Amyloidosis0.00008431Highly InformativeDirect
Phenotypic Abnormality (PA)Arthralgia0.000451Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of T cell physiology0.0004829Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pericardium0.0005994Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the peritoneum0.0006246Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.0000002209Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0000007081Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.00004705Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.2333Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5456Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.00000000001869Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.00000003114Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0000007548Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.000004495Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.0006226Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.0007516Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0.001072Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.002323Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01245Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.02986Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.08348Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.136Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.1364Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.1499Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.5749Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.0002592InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0003213InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0006527InformativeDirect
Mammalian Phenotype (MP)abnormal lymph node morphology0.01149InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.01409InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.02442InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/ coenzyme level0.08253InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.1233InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.1706InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.2027InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2251InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.2973InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.3665InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.5974InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8436InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.8966InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.00000000007426Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.0000003547Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes0.000001459Highly InformativeDirect
Mammalian Phenotype (MP)decreased interferon-alpha secretion0.000002519Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spleen germinal center morphology0.00002814Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gut flora balance0.00006645Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.00008464Highly InformativeDirect
Mammalian Phenotype (MP)abnormal acute inflammation0.000123Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.0001449Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis0.0001795Highly InformativeDirect
Mammalian Phenotype (MP)decreased inflammatory response0.0002734Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell proliferation0.0004497Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-6 secretion0.06192Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0001952Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.003962Least InformativeInherited
Worm Phenotype (WP)cell death variant0.05475Moderately InformativeInherited
Worm Phenotype (WP)cell corpse number variant0.00004879InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0001888InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)portion of tissue0.02184Moderately InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.0005897InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0000002314Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.00001369Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0004461InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0000003885Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0.000009007Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0.000000000001672InformativeDirect
Biological processmRNA splicing0.0001416InformativeDirect
Cellular componentNucleus0.00000000001443Least InformativeDirect
Cellular componentCytoplasm0.0000002472Least InformativeDirect
Cellular componentMembrane0.0005164Least InformativeDirect
Cellular componentCytoskeleton0.00006039Moderately InformativeDirect
Cellular componentCell junction0.007226Moderately InformativeInherited
Cellular componentSynapse0.06198InformativeInherited
Cellular componentPostsynaptic cell membrane0.00001844Highly InformativeDirect
Coding sequence diversityPolymorphism0.0005892Moderately InformativeDirect
DiseaseDisease mutation0.0009948Least InformativeDirect
DiseaseAmyloidosis0.00000006638Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0.9752Least InformativeInherited
DomainANK repeat0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainImmunoglobulin domain0.0000000165InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease0.000000000005301Moderately InformativeDirect
Post-translational modificationActivator0.0006638Moderately InformativeDirect
Post-translational modificationKinase0.1303Moderately InformativeInherited
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.000000001347InformativeDirect
Post-translational modificationPhosphoprotein0.0000000000008922Least InformativeDirect
Post-translational modificationUbl conjugation0.00000001712Moderately InformativeDirect
Post-translational modificationZymogen0.000000000008381InformativeDirect
Post-translational modificationHydroxylation0.0001733InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011029 SSF47986 Protein matches
Abstract

The death domain (DD) is a conserved region of about 80 residues found on death receptors, and which is required for death signalling, as well as a variety of non-apoptotic functions [PubMed11828422, PubMed12655292]. Proteins containing this domain include the low affinity neurotrophin receptor p73, Fas, FADD (Fas-associated death domain protein), TNF-1 (tumour necrosis factor receptor-1), Pelle protein kinase, and the Tube adaptor protein [PubMed15226512].

The induction of apoptosis also relies on the presence of a second domain, called the death effector domain. The death effector domain (DED) occurs in proteins that regulate programmed cell death, including both pro- and anti-apoptotic proteins; many of these proteins are also involved in controlling cellular activation and proliferation pathways [PubMed12719729]. Proteins containing this domain include FADD (DED N-terminal, DD C-terminal), PEA-15 (phosphoproteins enriched in astrocytes 15kDa), caspases and FLIP.

The induction of apoptosis results in the activation of caspases, a family of aspartyl-specific cysteine proteases that are the main executioners of apoptosis. For example, the DED of FADD recruits two DED-containing caspases, caspase-8 and caspase-10, to form the death-inducing signal complex, which initiates apoptosis. Proteins containing the caspase recruitment domain (CARD) are involved in the recruitment and activation of caspases during apoptosis [PubMed12101092]. Other CARD proteins participate in NF-kappaB signalling pathways associated with innate or adaptive immune responses. Proteins containing CARD include Raidd, APAF-1 (apoptotic protease activating factor 1), procaspase 9 and iceberg (inhibitor of interleukin-1-beta generation).

The DD shows strong structural similarity to both DED and CARD. They all display a 6-helical closed bundle fold, with greek key topology and an internal psuedo two-fold symmetry. However, despite their overall similarity in topology, each domain forms specialised interactions, typically only with members of its own subfamily, for example DED with DED.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DEATH domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the DEATH domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]