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DEATH domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DEATH domain [ 47985]
Superfamily:   DEATH domain [ 47986] (4)
Families:   DEATH domain, DD [ 81312] (8)
  DEATH effector domain, DED [ 81388] (2)
  Caspase recruitment domain, CARD [ 81313] (5)
  Pyrin domain, PYD [ 101298] (2)

Superfamily statistics
Genomes (127) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 9,180 8,245 25
Proteins 8,086 7,308 25

 Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus1.495e-060Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00046320Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.35720.1787Least InformativeInherited
Biological Process (BP)regulation of cellular process0.001390.0008375Least InformativeInherited
Biological Process (BP)response to organic substance7.848e-085.187e-05Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process3.7e-060Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00047463.053e-08Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process0.0016151Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process0.001881Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0019270.1434Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.017610Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.22051Moderately InformativeInherited
Biological Process (BP)regulation of localization0.017120.001992Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.030960.002664Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production3.459e-060InformativeDirect
Biological Process (BP)defense response5.099e-050InformativeDirect
Biological Process (BP)regulation of apoptotic process0.00025941.167e-05InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.0022822.591e-08InformativeInherited
Biological Process (BP)positive regulation of cytokine production2.496e-070Highly InformativeDirect
Molecular Function (MF)binding0.00040670Least InformativeDirect
Molecular Function (MF)protein binding1.01e-060Moderately InformativeDirect
Molecular Function (MF)heterocyclic compound binding0.12131Moderately InformativeInherited
Molecular Function (MF)organic cyclic compound binding0.14171Moderately InformativeInherited
Molecular Function (MF)DNA binding1.06e-050.362InformativeInherited
Molecular Function (MF)structure-specific DNA binding3.448e-080.02392Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0008375 Least Informative Direct
Biological Process (BP) multicellular organismal process 5.542e-11 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1.6e-06 Least Informative Direct
Biological Process (BP) developmental process 1.178e-05 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0001186 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1787 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to organic substance 5.187e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 3.053e-08 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 1.045e-06 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 1.379e-07 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 3.367e-13 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) signal transduction 9.457e-12 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.000194 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1527 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.5536 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9193 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2451 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.6745 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.001992 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.1434 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.002664 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.02571 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.2371 Moderately Informative Inherited
Biological Process (BP) organ development 0.153 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.003024 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.04149 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.02846 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.2369 Moderately Informative Inherited
Biological Process (BP) ion transport 0.6854 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.8321 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.9193 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.9289 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.9701 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.06384 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.06705 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.8494 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.719 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4714 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 1.167e-05 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 2.591e-08 Informative Direct
Biological Process (BP) response to cytokine stimulus 2.357e-13 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) response to other organism 2.081e-14 Informative Direct
Biological Process (BP) regulation of response to stress 6.081e-13 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 8.523e-11 Informative Direct
Biological Process (BP) protein oligomerization 1.467e-09 Informative Direct
Biological Process (BP) generation of neurons 6.198e-09 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 9.385e-08 Informative Direct
Biological Process (BP) regulation of protein localization 3.705e-07 Informative Direct
Biological Process (BP) proteolysis 5.182e-07 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 6.766e-07 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.115e-06 Informative Direct
Biological Process (BP) positive regulation of phosphorus metabolic process 8.282e-06 Informative Direct
Biological Process (BP) locomotion 1.128e-05 Informative Direct
Biological Process (BP) protein phosphorylation 2.079e-05 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 2.439e-05 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0001066 Informative Direct
Biological Process (BP) positive regulation of transport 0.0001181 Informative Direct
Biological Process (BP) cell projection organization 0.0002563 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.8766 Informative Inherited
Biological Process (BP) apoptotic process 0.004576 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.05753 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1283 Informative Inherited
Biological Process (BP) regulation of locomotion 0.2696 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.02854 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) tube development 0.1942 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.5183 Informative Inherited
Biological Process (BP) response to external stimulus 0.003753 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.9036 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.5774 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.1477 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.009732 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.02857 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.06562 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.528 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.1383 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1757 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.4119 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.05204 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.3696 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.3539 Informative Inherited
Biological Process (BP) response to organic nitrogen 0.01047 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1923 Informative Inherited
Biological Process (BP) response to lipid 0.003883 Informative Inherited
Biological Process (BP) muscle tissue development 0.006117 Informative Inherited
Biological Process (BP) response to light stimulus 0.1405 Informative Inherited
Biological Process (BP) protein transport 0.02014 Informative Inherited
Biological Process (BP) secretion 0.1434 Informative Inherited
Biological Process (BP) muscle structure development 0.02359 Informative Inherited
Biological Process (BP) cellular component disassembly 0.04325 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.4334 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.06108 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.2025 Informative Inherited
Biological Process (BP) immune effector process 0.6495 Informative Inherited
Biological Process (BP) cell activation 0.05553 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) chordate embryonic development 0.6153 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.7117 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3285 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.005192 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.04459 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.9082 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.2443 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0 Highly Informative Direct
Biological Process (BP) activation of immune response 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 0 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte activation 1.152e-13 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 8.885e-13 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 1.079e-11 Highly Informative Direct
Biological Process (BP) apoptotic signaling pathway 1.928e-11 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 1.021e-10 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 3.025e-10 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 4.671e-10 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 5.007e-10 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 1.327e-09 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 2.355e-08 Highly Informative Direct
Biological Process (BP) hair cycle process 1.223e-07 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 1.455e-07 Highly Informative Direct
Biological Process (BP) regulation of protein secretion 2.049e-07 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 production 5.835e-07 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 1.4e-06 Highly Informative Direct
Biological Process (BP) tube formation 3.132e-06 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 5.687e-06 Highly Informative Direct
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 8.721e-06 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 1.899e-05 Highly Informative Direct
Biological Process (BP) plasma membrane organization 3.162e-05 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 3.353e-05 Highly Informative Direct
Biological Process (BP) cellular component disassembly involved in execution phase of apoptosis 3.573e-05 Highly Informative Direct
Biological Process (BP) protein localization to membrane 3.716e-05 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 7.025e-05 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 8.659e-05 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0001187 Highly Informative Direct
Biological Process (BP) response to UV 0.0001678 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0002378 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.0004521 Highly Informative Direct
Biological Process (BP) axonogenesis 0.0007276 Highly Informative Direct
Biological Process (BP) defense response to Gram-positive bacterium 0.0007397 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.00224 Highly Informative Inherited
Biological Process (BP) regulation of neurological system process 0.03407 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.04952 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.6537 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.8777 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.004276 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.01747 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.7624 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.00107 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.002461 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.006431 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.1618 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.115 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.789 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.00583 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.2191 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.01466 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.00264 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.9011 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.00282 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.8778 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.8023 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.3852 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.00104 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.01944 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response 0.3972 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.005266 Highly Informative Inherited
Biological Process (BP) response to fungus 0.2889 Highly Informative Inherited
Biological Process (BP) innate immune response 0.003015 Highly Informative Inherited
Biological Process (BP) epidermis development 0.2782 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.01933 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.2776 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.678 Least Informative Inherited
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.0002254 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 1.117e-12 Informative Direct
Molecular Function (MF) enzyme activator activity 2.881e-12 Informative Direct
Molecular Function (MF) receptor activity 2.303e-06 Informative Direct
Molecular Function (MF) molecular transducer activity 3.447e-06 Informative Direct
Molecular Function (MF) peptidase regulator activity 3.224e-05 Informative Direct
Molecular Function (MF) enzyme binding 0.0004339 Informative Direct
Molecular Function (MF) receptor binding 0.3721 Informative Inherited
Molecular Function (MF) DNA binding 0.362 Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 4.459e-07 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.6988 Highly Informative Inherited
Molecular Function (MF) glycosaminoglycan binding 0.007265 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 0.01213 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.04111 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 0.02392 Highly Informative Inherited
Cellular Component (CC) membrane 1.037e-13 Least Informative Direct
Cellular Component (CC) protein complex 1.108e-07 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0337 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.06483 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 9.205e-13 Moderately Informative Direct
Cellular Component (CC) plasma membrane 8.347e-10 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.001566 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.1022 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.2471 Moderately Informative Inherited
Cellular Component (CC) neuron part 1.335e-08 Informative Direct
Cellular Component (CC) synapse 1.241e-05 Informative Direct
Cellular Component (CC) cell projection part 8.217e-05 Informative Direct
Cellular Component (CC) cell junction 0.000654 Informative Direct
Cellular Component (CC) cell surface 0.0007954 Informative Direct
Cellular Component (CC) integral to membrane 0.7736 Informative Inherited
Cellular Component (CC) cell cortex 0.05621 Informative Inherited
Cellular Component (CC) membrane raft 6.296e-12 Highly Informative Direct
Cellular Component (CC) axon part 8.495e-10 Highly Informative Direct
Cellular Component (CC) neuromuscular junction 2.233e-06 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 2.546e-06 Highly Informative Direct
Cellular Component (CC) synaptic membrane 3.042e-06 Highly Informative Direct
Cellular Component (CC) cell-cell junction 5.119e-06 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 1.699e-05 Highly Informative Direct
Cellular Component (CC) receptor complex 0.001347 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.05988Least InformativeInherited
Disease Ontology (DO)disease by infectious agent4.614e-07Moderately InformativeDirect
Disease Ontology (DO)bone disease0.0002032Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.005361Moderately InformativeInherited
Disease Ontology (DO)syndrome0.04191Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease1.469e-06InformativeDirect
Disease Ontology (DO)arthropathy0.01345InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.03047InformativeInherited
Disease Ontology (DO)viral infectious disease1InformativeInherited
Disease Ontology (DO)irritable bowel syndrome9.723e-06Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.322Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.4128Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7306Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the central nervous system1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.004621Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.009129Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1421Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2792Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.618Moderately InformativeInherited
Phenotypic Abnormality (PA)Malformation of the heart and great vessels0.8884Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the spleen0.0006302InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.001415InformativeInherited
Phenotypic Abnormality (PA)Visceromegaly0.004954InformativeInherited
Phenotypic Abnormality (PA)Abnormality of leukocytes0.09077InformativeInherited
Phenotypic Abnormality (PA)Abnormality of humoral immunity0.3288InformativeInherited
Phenotypic Abnormality (PA)Vasculitis4.378e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of temperature regulation3.422e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Lymphadenopathy5.396e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Leukocytosis1.114e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Elevated erythrocyte sedimentation rate4.87e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Increased IgM level9.142e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Amyloidosis0.0001184Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0001471Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the peritoneum0.000189Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of T cell physiology0.0004062Highly InformativeDirect
Phenotypic Abnormality (PA)Arthralgia0.0004553Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pericardium0.000509Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype4.885e-07Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0001043Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.2732Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4888Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection4.979e-08Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level3.815e-07Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology5.056e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.001546Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.001785Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.002327Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.002418Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.03937Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.04662Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.1412Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.1707Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1993Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.5741Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.000393InformativeDirect
Mammalian Phenotype (MP)abnormal innate immunity0.0009013InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion0.001715InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.002634InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.04159InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.04446InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.06558InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/ coenzyme level0.07616InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.1074InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.3387InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.3649InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.4909InformativeInherited
Mammalian Phenotype (MP)increased inflammatory response0.8293InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.8955InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.9072InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion4.279e-11Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size6.872e-06Highly InformativeDirect
Mammalian Phenotype (MP)decreased IgG level7.808e-06Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis2.444e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spleen germinal center morphology3.256e-05Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes7.452e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number8.928e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal acute inflammation0.0001151Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gut flora balance0.0001188Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.0001388Highly InformativeDirect
Mammalian Phenotype (MP)decreased inflammatory response0.0003204Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-6 secretion0.07417Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0001952Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.003962Least InformativeInherited
Worm Phenotype (WP)cell death variant0.05475Moderately InformativeInherited
Worm Phenotype (WP)cell corpse number variant4.879e-05InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0001888InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0.5279Least InformativeInherited
Fly Anatomy (FA)portion of tissue0.02273Moderately InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.0007611InformativeDirect
Fly Anatomy (FA)hemocyte0.0008021InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases3.011e-07Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1.561e-05Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0004713InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase4.299e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation2.656e-06Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processmRNA splicing0.000115InformativeDirect
Cellular componentNucleus1.022e-11Least InformativeDirect
Cellular componentCytoplasm1.509e-07Least InformativeDirect
Cellular componentCytoskeleton8.99e-05Moderately InformativeDirect
Coding sequence diversityPolymorphism0.0003997Moderately InformativeDirect
DiseaseAmyloidosis9.025e-09Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainANK repeat0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainImmunoglobulin domain2.127e-08InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease2.813e-12Moderately InformativeDirect
Post-translational modificationActivator0.0005303Moderately InformativeDirect
Post-translational modificationKinase0.1135Moderately InformativeInherited
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase1.113e-09InformativeDirect
Post-translational modificationPhosphoprotein3.898e-15Least InformativeDirect
Post-translational modificationUbl conjugation1.666e-07Moderately InformativeDirect
Post-translational modificationZymogen3.376e-12InformativeDirect
Post-translational modificationHydroxylation9.615e-05InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011029 SSF47986 Protein matches
Abstract

The death domain (DD) is a conserved region of about 80 residues found on death receptors, and which is required for death signalling, as well as a variety of non-apoptotic functions [PubMed11828422, PubMed12655292]. Proteins containing this domain include the low affinity neurotrophin receptor p73, Fas, FADD (Fas-associated death domain protein), TNF-1 (tumour necrosis factor receptor-1), Pelle protein kinase, and the Tube adaptor protein [PubMed15226512].

The induction of apoptosis also relies on the presence of a second domain, called the death effector domain. The death effector domain (DED) occurs in proteins that regulate programmed cell death, including both pro- and anti-apoptotic proteins; many of these proteins are also involved in controlling cellular activation and proliferation pathways [PubMed12719729]. Proteins containing this domain include FADD (DED N-terminal, DD C-terminal), PEA-15 (phosphoproteins enriched in astrocytes 15kDa), caspases and FLIP.

The induction of apoptosis results in the activation of caspases, a family of aspartyl-specific cysteine proteases that are the main executioners of apoptosis. For example, the DED of FADD recruits two DED-containing caspases, caspase-8 and caspase-10, to form the death-inducing signal complex, which initiates apoptosis. Proteins containing the caspase recruitment domain (CARD) are involved in the recruitment and activation of caspases during apoptosis [PubMed12101092]. Other CARD proteins participate in NF-kappaB signalling pathways associated with innate or adaptive immune responses. Proteins containing CARD include Raidd, APAF-1 (apoptotic protease activating factor 1), procaspase 9 and iceberg (inhibitor of interleukin-1-beta generation).

The DD shows strong structural similarity to both DED and CARD. They all display a 6-helical closed bundle fold, with greek key topology and an internal psuedo two-fold symmetry. However, despite their overall similarity in topology, each domain forms specialised interactions, typically only with members of its own subfamily, for example DED with DED.


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DEATH domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the DEATH domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.