SUPERFAMILY 1.75 HMM library and genome assignments server


DEATH domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DEATH domain [ 47985]
Superfamily:   DEATH domain [ 47986] (4)
Families:   DEATH domain, DD [ 81312] (8)
  DEATH effector domain, DED [ 81388] (2)
  Caspase recruitment domain, CARD [ 81313] (5)
  Pyrin domain, PYD [ 101298] (2)


Superfamily statistics
Genomes (129) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 9,298 8,245 25
Proteins 8,197 7,308 25


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus7.336e-070Least InformativeDirect
Biological Process (BP)regulation of cellular process7.469e-075.996e-05Least InformativeDirect
Biological Process (BP)single-organism cellular process2.57e-050Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.8350.9264Least InformativeInherited
Biological Process (BP)positive regulation of cellular process9.576e-110Moderately InformativeDirect
Biological Process (BP)response to organic substance4.754e-080.0003089Moderately InformativeDirect
Biological Process (BP)regulation of localization2.498e-056.187e-10Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process7.625e-051.922e-09Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00031087.616e-08Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.00079350.02149Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.001150.0001653Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.001440.05656Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0014050.005449Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production1.207e-140InformativeDirect
Biological Process (BP)regulation of establishment of protein localization4.38e-100InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process1.929e-070InformativeDirect
Biological Process (BP)defense response3.695e-050InformativeDirect
Biological Process (BP)positive regulation of transport4.656e-054.001e-05InformativeDirect
Biological Process (BP)regulation of secretion0.023190.0269InformativeInherited
Biological Process (BP)positive regulation of cytokine production00Highly InformativeDirect
Biological Process (BP)regulation of interleukin-1 beta production1.784e-140Highly InformativeDirect
Biological Process (BP)regulation of protein secretion4.407e-121.173e-13Highly InformativeDirect
Biological Process (BP)positive regulation of secretion0.0012491.337e-05Highly InformativeInherited
Biological Process (BP)positive regulation of protein transport0.0027555.078e-14Highly InformativeInherited
Molecular Function (MF)binding0.00029340Least InformativeDirect
Molecular Function (MF)nucleic acid binding9.615e-050.9665Moderately InformativeInherited
Molecular Function (MF)DNA binding6.133e-060.3688InformativeInherited
Molecular Function (MF)structure-specific DNA binding3.842e-080.03889Highly InformativeInherited
Cellular Component (CC)protein complex0.00024660Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 5.996e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 3.428e-12 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 6.015e-09 Least Informative Direct
Biological Process (BP) protein metabolic process 2.58e-07 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9264 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0003089 Moderately Informative Direct
Biological Process (BP) regulation of localization 6.187e-10 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1.922e-09 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 7.616e-08 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0001653 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 2.933e-13 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 1.047e-12 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 9.727e-08 Moderately Informative Direct
Biological Process (BP) homeostatic process 2.626e-06 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.00383 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.0934 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4027 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.08137 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.002144 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1151 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.05656 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.005449 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.02149 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5636 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.1967 Moderately Informative Inherited
Biological Process (BP) organ development 0.1112 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01555 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.2068 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1961 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.8586 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.9016 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.07099 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.06483 Moderately Informative Inherited
Biological Process (BP) tissue development 0.824 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) positive regulation of transport 4.001e-05 Informative Direct
Biological Process (BP) cell death 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) regulation of defense response 3.746e-15 Informative Direct
Biological Process (BP) response to bacterium 3.746e-15 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 1.605e-14 Informative Direct
Biological Process (BP) protein complex assembly 1.718e-12 Informative Direct
Biological Process (BP) generation of neurons 1.959e-12 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 1.372e-10 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 1.011e-09 Informative Direct
Biological Process (BP) locomotion 6.709e-09 Informative Direct
Biological Process (BP) regulation of cellular component movement 1.285e-08 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 4.185e-08 Informative Direct
Biological Process (BP) negative regulation of cell death 5.691e-08 Informative Direct
Biological Process (BP) regulation of locomotion 1.417e-07 Informative Direct
Biological Process (BP) cell activation 1.936e-07 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 2.752e-07 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 9.173e-07 Informative Direct
Biological Process (BP) cellular component morphogenesis 6.23e-05 Informative Direct
Biological Process (BP) proteolysis 0.0002557 Informative Direct
Biological Process (BP) regulation of immune effector process 0.0004155 Informative Direct
Biological Process (BP) regulation of nervous system development 0.5584 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) cell projection organization 0.002099 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.3995 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.08253 Informative Inherited
Biological Process (BP) membrane organization 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.9313 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.02171 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1051 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.9813 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.09485 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.02258 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.09008 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.0269 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) phosphorylation 0.05224 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.1959 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.5365 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.03397 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.3332 Informative Inherited
Biological Process (BP) cellular component movement 0.1325 Informative Inherited
Biological Process (BP) localization of cell 0.5849 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.2071 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.6144 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.006218 Informative Inherited
Biological Process (BP) response to nutrient levels 0.3477 Informative Inherited
Biological Process (BP) response to lipid 0.005423 Informative Inherited
Biological Process (BP) muscle tissue development 0.001882 Informative Inherited
Biological Process (BP) response to light stimulus 0.1542 Informative Inherited
Biological Process (BP) protein transport 0.02235 Informative Inherited
Biological Process (BP) secretion by cell 0.9794 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.001468 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.2604 Informative Inherited
Biological Process (BP) regulation of cell development 0.1283 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of growth 0.7481 Informative Inherited
Biological Process (BP) single-organism behavior 0.5456 Informative Inherited
Biological Process (BP) muscle structure development 0.1618 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.09251 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.4401 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.02359 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.805 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 0 Highly Informative Direct
Biological Process (BP) regulation of protein secretion 1.173e-13 Highly Informative Direct
Biological Process (BP) positive regulation of secretion 1.337e-05 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 5.078e-14 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) execution phase of apoptosis 0 Highly Informative Direct
Biological Process (BP) activation of immune response 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 0 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 1.931e-15 Highly Informative Direct
Biological Process (BP) regulation of cell killing 3.746e-15 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 1.538e-12 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 5.386e-09 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 9.432e-09 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 1.171e-08 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 6.185e-08 Highly Informative Direct
Biological Process (BP) hair follicle development 4.379e-07 Highly Informative Direct
Biological Process (BP) myeloid cell development 2.052e-06 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 2.126e-06 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 2.554e-06 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 5.38e-06 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response 8.533e-06 Highly Informative Direct
Biological Process (BP) defense response to bacterium 1.633e-05 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 1.799e-05 Highly Informative Direct
Biological Process (BP) tube formation 3.262e-05 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte mediated immunity 3.784e-05 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte migration 4.735e-05 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 6.147e-05 Highly Informative Direct
Biological Process (BP) plasma membrane organization 8.418e-05 Highly Informative Direct
Biological Process (BP) response to UV 0.000169 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0.0001949 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0003034 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0004088 Highly Informative Direct
Biological Process (BP) neural tube development 0.0005728 Highly Informative Direct
Biological Process (BP) T cell differentiation 0.000573 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.0005984 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.3015 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) regulation of response to biotic stimulus 0.03082 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.5018 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.001287 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.1982 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 1 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.8885 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.006005 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.001592 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.01804 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.5713 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.009272 Highly Informative Inherited
Biological Process (BP) placenta development 0.0462 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.7811 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 1 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.0127 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.01251 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.1307 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.1659 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.9661 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.3932 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.001917 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.9933 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.827 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.5212 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.07413 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.1684 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.01574 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.02815 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.962 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.07466 Highly Informative Inherited
Biological Process (BP) fatty acid derivative metabolic process 0.001191 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.003576 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.001444 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.01183 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.23 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.12 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.4112 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.001285 Highly Informative Inherited
Biological Process (BP) response to fungus 0.6006 Highly Informative Inherited
Biological Process (BP) innate immune response 0.003058 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.01795 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.0254 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.002778 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0001998 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.002034 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.9665 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) enzyme activator activity 2.795e-12 Informative Direct
Molecular Function (MF) receptor activity 3.782e-06 Informative Direct
Molecular Function (MF) molecular transducer activity 4.428e-06 Informative Direct
Molecular Function (MF) peptidase regulator activity 6.27e-06 Informative Direct
Molecular Function (MF) kinase activity 0.0001348 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0003443 Informative Direct
Molecular Function (MF) enzyme binding 0.000554 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.3013 Informative Inherited
Molecular Function (MF) amide binding 0.003001 Informative Inherited
Molecular Function (MF) receptor binding 0.4411 Informative Inherited
Molecular Function (MF) DNA binding 0.3688 Informative Inherited
Molecular Function (MF) cytokine receptor binding 8.923e-15 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 8.149e-12 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 5.947e-10 Highly Informative Direct
Molecular Function (MF) peptide binding 4.253e-06 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 6.822e-06 Highly Informative Direct
Molecular Function (MF) protein kinase activity 6.914e-06 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.7549 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.04919 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 0.03889 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) membrane 3.567e-14 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.1098 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.007511 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 4.034e-13 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.0002211 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.008239 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.005089 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.2284 Moderately Informative Inherited
Cellular Component (CC) cell-cell junction 2.889e-05 Informative Direct
Cellular Component (CC) neuron projection 3.805e-05 Informative Direct
Cellular Component (CC) synapse part 7.872e-05 Informative Direct
Cellular Component (CC) integral to membrane 0.8155 Informative Inherited
Cellular Component (CC) cell cortex 0.07478 Informative Inherited
Cellular Component (CC) cell-cell contact zone 1.061e-11 Highly Informative Direct
Cellular Component (CC) membrane raft 2.608e-11 Highly Informative Direct
Cellular Component (CC) axon part 1.131e-07 Highly Informative Direct
Cellular Component (CC) neuromuscular junction 1.15e-06 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 4.744e-06 Highly Informative Direct
Cellular Component (CC) synaptic membrane 7.179e-06 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.0002799 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0.000455 Highly Informative Direct
Cellular Component (CC) receptor complex 0.06139 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.04444Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.003633Moderately InformativeInherited
Disease Ontology (DO)syndrome0.06051Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system disease0.06442Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.9887Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease8.894e-07InformativeDirect
Disease Ontology (DO)arthropathy0.03098InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.03104InformativeInherited
Disease Ontology (DO)viral infectious disease1InformativeInherited
Disease Ontology (DO)irritable bowel syndrome6.142e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.2984Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.4537Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.7787Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.005107Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.009785Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.09311Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1787Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.6258Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.7195Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the spleen0.0001253InformativeDirect
Phenotypic Abnormality (PA)Visceromegaly0.00127InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.004774InformativeInherited
Phenotypic Abnormality (PA)Abnormality of leukocytes0.0361InformativeInherited
Phenotypic Abnormality (PA)Abnormality of humoral immunity0.1576InformativeInherited
Phenotypic Abnormality (PA)Vasculitis3.225e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Lymphadenopathy4.694e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of temperature regulation3.137e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Leukocytosis1.158e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Elevated erythrocyte sedimentation rate3.371e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Increased IgM level8.442e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Amyloidosis8.442e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Arthralgia0.0004531Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of T cell physiology0.000485Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pericardium0.0006021Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the peritoneum0.0006285Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype2.26e-07Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype7.098e-07Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype1.811e-05Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.2322Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6057Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection2.866e-08Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology6.032e-07Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level3.583e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hematopoietic system physiology0.0005848Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.0006573Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.0007941Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0.001134Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.002869Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01218Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.02791Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.08049Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.134Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.1389Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.5655Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.5685Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.0002373InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0003152InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0006InformativeDirect
Mammalian Phenotype (MP)abnormal lymph node morphology0.01145InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.01344InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.02325InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.04349InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/ coenzyme level0.07888InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.1279InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.1717InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.2041InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2568InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.2884InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.3335InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.5534InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8433InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.8919InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion5.656e-11Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size3.778e-07Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes1.234e-06Highly InformativeDirect
Mammalian Phenotype (MP)decreased IgG level1.579e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spleen germinal center morphology2.808e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gut flora balance7.023e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number9.032e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal acute inflammation0.0001247Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.0001521Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis0.0001969Highly InformativeDirect
Mammalian Phenotype (MP)decreased inflammatory response0.0002971Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell proliferation0.0004762Highly InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage apoptosis0.0009244Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-6 secretion0.05516Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0001952Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.003962Least InformativeInherited
Worm Phenotype (WP)cell death variant0.05475Moderately InformativeInherited
Worm Phenotype (WP)cell corpse number variant4.879e-05InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0001888InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)portion of tissue0.02198Moderately InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.000589InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases2.708e-07Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1.552e-05Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0004516InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase4.067e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation7.269e-06Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity2.488e-11InformativeDirect
Biological processmRNA splicing0.0001249InformativeDirect
Cellular componentNucleus6.993e-11Least InformativeDirect
Cellular componentCytoplasm3.664e-07Least InformativeDirect
Cellular componentMembrane0.0007419Least InformativeDirect
Cellular componentCytoskeleton0.0001626Moderately InformativeDirect
Coding sequence diversityPolymorphism0.0005322Moderately InformativeDirect
DiseaseAmyloidosis3.21e-08Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0.9469Least InformativeInherited
DomainANK repeat0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainImmunoglobulin domain1.451e-08InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease4.072e-12Moderately InformativeDirect
Post-translational modificationActivator0.0006198Moderately InformativeDirect
Post-translational modificationKinase0.123Moderately InformativeInherited
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase1.231e-09InformativeDirect
Post-translational modificationPhosphoprotein1.58e-12Least InformativeDirect
Post-translational modificationUbl conjugation1.309e-08Moderately InformativeDirect
Post-translational modificationZymogen7.176e-12InformativeDirect
Post-translational modificationHydroxylation0.0001323InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011029 SSF47986 Protein matches
Abstract

The death domain (DD) is a conserved region of about 80 residues found on death receptors, and which is required for death signalling, as well as a variety of non-apoptotic functions [PubMed11828422, PubMed12655292]. Proteins containing this domain include the low affinity neurotrophin receptor p73, Fas, FADD (Fas-associated death domain protein), TNF-1 (tumour necrosis factor receptor-1), Pelle protein kinase, and the Tube adaptor protein [PubMed15226512].

The induction of apoptosis also relies on the presence of a second domain, called the death effector domain. The death effector domain (DED) occurs in proteins that regulate programmed cell death, including both pro- and anti-apoptotic proteins; many of these proteins are also involved in controlling cellular activation and proliferation pathways [PubMed12719729]. Proteins containing this domain include FADD (DED N-terminal, DD C-terminal), PEA-15 (phosphoproteins enriched in astrocytes 15kDa), caspases and FLIP.

The induction of apoptosis results in the activation of caspases, a family of aspartyl-specific cysteine proteases that are the main executioners of apoptosis. For example, the DED of FADD recruits two DED-containing caspases, caspase-8 and caspase-10, to form the death-inducing signal complex, which initiates apoptosis. Proteins containing the caspase recruitment domain (CARD) are involved in the recruitment and activation of caspases during apoptosis [PubMed12101092]. Other CARD proteins participate in NF-kappaB signalling pathways associated with innate or adaptive immune responses. Proteins containing CARD include Raidd, APAF-1 (apoptotic protease activating factor 1), procaspase 9 and iceberg (inhibitor of interleukin-1-beta generation).

The DD shows strong structural similarity to both DED and CARD. They all display a 6-helical closed bundle fold, with greek key topology and an internal psuedo two-fold symmetry. However, despite their overall similarity in topology, each domain forms specialised interactions, typically only with members of its own subfamily, for example DED with DED.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DEATH domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the DEATH domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]