SUPERFAMILY 1.75 HMM library and genome assignments server


DEATH domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DEATH domain [ 47985]
Superfamily:   DEATH domain [ 47986] (4)
Families:   DEATH domain, DD [ 81312] (8)
  DEATH effector domain, DED [ 81388] (2)
  Caspase recruitment domain, CARD [ 81313] (5)
  Pyrin domain, PYD [ 101298] (2)


Superfamily statistics
Genomes (141) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,881 9,865 25
Proteins 8,717 8,797 25


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus1.757e-070Least InformativeDirect
Biological Process (BP)regulation of cellular process3.977e-074.118e-05Least InformativeDirect
Biological Process (BP)single-organism cellular process1.762e-050Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.67581Least InformativeInherited
Biological Process (BP)positive regulation of cellular process2.3e-110Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process2.158e-054.946e-10Moderately InformativeDirect
Biological Process (BP)regulation of localization0.00010719.302e-11Moderately InformativeDirect
Biological Process (BP)regulation of programmed cell death0.00036840.0004001Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0022730.04829Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.068891Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.00020340.002774Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction5.348e-061Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.091640Moderately InformativeInherited
Biological Process (BP)regulation of establishment of protein localization1.693e-090InformativeDirect
Biological Process (BP)positive regulation of signal transduction1.31e-070.0004553InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process1.033e-060InformativeDirect
Biological Process (BP)regulation of cytokine production7.282e-060InformativeDirect
Biological Process (BP)defense response7.886e-050InformativeDirect
Biological Process (BP)positive regulation of transport0.00015280.006575InformativeInherited
Biological Process (BP)regulation of secretion0.025590.08196InformativeInherited
Biological Process (BP)positive regulation of cytokine production00Highly InformativeDirect
Biological Process (BP)regulation of interleukin-1 beta production3.986e-140Highly InformativeDirect
Biological Process (BP)positive regulation of protein secretion5.505e-061.705e-13Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion0.0030920.002531Highly InformativeInherited
Molecular Function (MF)binding0.00011140Least InformativeDirect
Molecular Function (MF)nucleic acid binding0.00017191Moderately InformativeInherited
Molecular Function (MF)DNA binding1.189e-050.5389InformativeInherited
Molecular Function (MF)structure-specific DNA binding5.809e-080.05122Highly InformativeInherited
Cellular Component (CC)protein complex0.00058980Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 4.118e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 1.172e-06 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 4.946e-10 Moderately Informative Direct
Biological Process (BP) regulation of localization 9.302e-11 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 0.0004001 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 8.559e-07 Moderately Informative Direct
Biological Process (BP) signal transduction 6.197e-13 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 4.783e-11 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1.167e-08 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 4.568e-07 Moderately Informative Direct
Biological Process (BP) macromolecule localization 7.794e-06 Moderately Informative Direct
Biological Process (BP) homeostatic process 5.295e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0006554 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.02166 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.06453 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.4405 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.04829 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.002774 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1074 Moderately Informative Inherited
Biological Process (BP) organ development 0.7239 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.02335 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.06145 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.468 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.02618 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.9468 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.002443 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.9699 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.09476 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.0004553 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 1.208e-07 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0002821 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) response to other organism 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) regulation of defense response 3.77e-15 Informative Direct
Biological Process (BP) protein complex assembly 8.655e-14 Informative Direct
Biological Process (BP) locomotion 1.211e-13 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 2.478e-11 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 3.674e-10 Informative Direct
Biological Process (BP) cellular component morphogenesis 3.511e-09 Informative Direct
Biological Process (BP) regulation of cellular component movement 2.861e-08 Informative Direct
Biological Process (BP) cell projection organization 1.881e-07 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 2.031e-07 Informative Direct
Biological Process (BP) regulation of locomotion 2.928e-07 Informative Direct
Biological Process (BP) protein transport 1.472e-06 Informative Direct
Biological Process (BP) negative regulation of cell death 4.078e-06 Informative Direct
Biological Process (BP) blood circulation 8.97e-06 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 2.855e-05 Informative Direct
Biological Process (BP) muscle system process 4.568e-05 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0.0001439 Informative Direct
Biological Process (BP) proteolysis 0.0001759 Informative Direct
Biological Process (BP) regulation of immune effector process 0.0005436 Informative Direct
Biological Process (BP) regulation of nervous system development 0.1867 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) apoptotic process 0.1283 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.07088 Informative Inherited
Biological Process (BP) cellular membrane organization 0.1957 Informative Inherited
Biological Process (BP) tube development 0.3075 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.8217 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.01401 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.07291 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.8048 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.1042 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.998 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.00194 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.00818 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.7804 Informative Inherited
Biological Process (BP) positive regulation of transport 0.006575 Informative Inherited
Biological Process (BP) regulation of secretion 0.08196 Informative Inherited
Biological Process (BP) muscle structure development 0.001095 Informative Inherited
Biological Process (BP) muscle tissue development 0.003537 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) phosphorylation 0.08223 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.2881 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.9851 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.5809 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.04961 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.3252 Informative Inherited
Biological Process (BP) cellular component movement 0.0105 Informative Inherited
Biological Process (BP) localization of cell 0.7406 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.2558 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.7577 Informative Inherited
Biological Process (BP) regulation of ion transport 0.882 Informative Inherited
Biological Process (BP) response to nutrient levels 0.4246 Informative Inherited
Biological Process (BP) response to lipid 0.005263 Informative Inherited
Biological Process (BP) leukocyte activation 0.4392 Informative Inherited
Biological Process (BP) response to light stimulus 0.2034 Informative Inherited
Biological Process (BP) secretion by cell 0.9715 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.2475 Informative Inherited
Biological Process (BP) regulation of cell development 0.02055 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.4703 Informative Inherited
Biological Process (BP) regulation of growth 0.251 Informative Inherited
Biological Process (BP) single-organism behavior 0.0223 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.0952 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.9907 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.4976 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.0106 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 1.705e-13 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 1.944e-15 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0 Highly Informative Direct
Biological Process (BP) execution phase of apoptosis 0 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of cell killing 2.298e-14 Highly Informative Direct
Biological Process (BP) heart contraction 4.034e-13 Highly Informative Direct
Biological Process (BP) striated muscle contraction 1.518e-12 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 2.504e-12 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 3.594e-12 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 4.562e-10 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 1.594e-09 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 2.645e-09 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 7.818e-09 Highly Informative Direct
Biological Process (BP) axon development 8.286e-09 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 1.093e-08 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 3.458e-08 Highly Informative Direct
Biological Process (BP) hair follicle development 8.246e-08 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 9.026e-08 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 2.757e-07 Highly Informative Direct
Biological Process (BP) chemotaxis 5.328e-07 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 6.654e-07 Highly Informative Direct
Biological Process (BP) defense response to bacterium 8.017e-07 Highly Informative Direct
Biological Process (BP) learning or memory 1.861e-06 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 3.206e-06 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 4.108e-06 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 5.425e-06 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response 1.51e-05 Highly Informative Direct
Biological Process (BP) myeloid cell development 2.216e-05 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte mediated immunity 2.94e-05 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte migration 5.75e-05 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.0001306 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0.0001604 Highly Informative Direct
Biological Process (BP) response to UV 0.0002192 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0003663 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0004723 Highly Informative Direct
Biological Process (BP) T cell differentiation 0.0005279 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.0006139 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0007718 Highly Informative Direct
Biological Process (BP) epithelial tube formation 0.0008741 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.3694 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.2067 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.6948 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0.149 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.001675 Highly Informative Inherited
Biological Process (BP) sensory perception 0.004924 Highly Informative Inherited
Biological Process (BP) negative regulation of cell activation 0.04872 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.1227 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.001088 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.002531 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.01654 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.003638 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02092 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.01643 Highly Informative Inherited
Biological Process (BP) placenta development 0.09817 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.7869 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.4738 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.1437 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.2229 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.9459 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.01161 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.419 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.003305 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.9659 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.02564 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.07274 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.9624 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.07355 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.2793 Highly Informative Inherited
Biological Process (BP) icosanoid metabolic process 0.00154 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.004479 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.0127 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.2245 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.1244 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.4345 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.002028 Highly Informative Inherited
Biological Process (BP) response to fungus 0.7248 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.0201 Highly Informative Inherited
Biological Process (BP) neural tube development 0.002261 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.7878 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.002766 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0007047 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.003003 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) enzyme activator activity 8.423e-12 Informative Direct
Molecular Function (MF) peptidase regulator activity 6.879e-06 Informative Direct
Molecular Function (MF) receptor activity 1.099e-05 Informative Direct
Molecular Function (MF) molecular transducer activity 1.214e-05 Informative Direct
Molecular Function (MF) kinase activity 0.0001996 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0002593 Informative Direct
Molecular Function (MF) enzyme binding 0.0005683 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.3989 Informative Inherited
Molecular Function (MF) amide binding 0.009141 Informative Inherited
Molecular Function (MF) receptor binding 0.4323 Informative Inherited
Molecular Function (MF) DNA binding 0.5389 Informative Inherited
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 6.067e-12 Highly Informative Direct
Molecular Function (MF) channel regulator activity 1.386e-10 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 2.742e-10 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 4.751e-10 Highly Informative Direct
Molecular Function (MF) protein kinase activity 5.171e-06 Highly Informative Direct
Molecular Function (MF) peptide binding 1.117e-05 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 2.424e-05 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.8925 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.2319 Highly Informative Inherited
Molecular Function (MF) protein binding transcription factor activity 0.1352 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 0.05122 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0002054 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.04075 Least Informative Inherited
Cellular Component (CC) cytosol 5.063e-12 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1.04e-11 Moderately Informative Direct
Cellular Component (CC) cell projection 9.601e-08 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.038 Moderately Informative Inherited
Cellular Component (CC) neuron projection 1.771e-09 Informative Direct
Cellular Component (CC) cell-cell junction 3.84e-08 Informative Direct
Cellular Component (CC) synapse part 1.967e-07 Informative Direct
Cellular Component (CC) contractile fiber part 9.387e-07 Informative Direct
Cellular Component (CC) integral to membrane 0.8211 Informative Inherited
Cellular Component (CC) cell cortex 0.1006 Informative Inherited
Cellular Component (CC) cell-cell contact zone 0 Highly Informative Direct
Cellular Component (CC) membrane raft 3.2e-13 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 2.101e-07 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.0003881 Highly Informative Direct
Cellular Component (CC) main axon 0.002831 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.0706 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.06321 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.05332Least InformativeInherited
Disease Ontology (DO)bone disease0.0002317Moderately InformativeDirect
Disease Ontology (DO)syndrome0.04037Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.9818Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease1.239e-06InformativeDirect
Disease Ontology (DO)arthropathy0.01535InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.03237InformativeInherited
Disease Ontology (DO)viral infectious disease1InformativeInherited
Disease Ontology (DO)irritable bowel syndrome1.075e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.2385Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.3784Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.7868Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.787Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.002368Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.005331Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.145Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.6228Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.6657Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation4.018e-07InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the spleen0.0004651InformativeDirect
Phenotypic Abnormality (PA)Visceromegaly0.002492InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.004734InformativeInherited
Phenotypic Abnormality (PA)Abnormality of leukocytes0.0683InformativeInherited
Phenotypic Abnormality (PA)Vasculitis2.439e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Lymphadenopathy7.441e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Leukocytosis1.512e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Episodic fever2.457e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Elevated erythrocyte sedimentation rate2.661e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Increased IgM level9.899e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Amyloidosis0.0001146Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0001937Highly InformativeDirect
Phenotypic Abnormality (PA)Arthralgia0.0005161Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pericardium0.0005526Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of T cell physiology0.0005526Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the peritoneum0.0008667Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype2.259e-07Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype6.841e-07Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype5.021e-05Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.2317Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.544Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology1.638e-11Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology8.737e-07Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level4.604e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.0006134Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.0007421Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0.001078Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.002523Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01213Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.02993Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.08254Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.1326Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1346Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.1521Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.5801Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.0002782InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0003324InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0006915InformativeDirect
Mammalian Phenotype (MP)abnormal lymph node morphology0.01198InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.01322InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.02573InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/ coenzyme level0.08127InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.1229InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.1702InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.2061InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2153InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.2927InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.3639InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.6037InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8436InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.8943InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion8.319e-11Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size3.4e-07Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes1.469e-06Highly InformativeDirect
Mammalian Phenotype (MP)decreased interferon-alpha secretion2.455e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spleen germinal center morphology2.902e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gut flora balance6.586e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number8.175e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal acute inflammation0.0001278Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.0001408Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis0.0001537Highly InformativeDirect
Mammalian Phenotype (MP)decreased inflammatory response0.0002484Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell proliferation0.000443Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-6 secretion0.06766Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0001952Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.003962Least InformativeInherited
Worm Phenotype (WP)cell death variant0.05475Moderately InformativeInherited
Worm Phenotype (WP)cell corpse number variant4.879e-05InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0001888InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases2.305e-07Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1.366e-05Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0004448InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase3.867e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation8.945e-06Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity1.673e-12InformativeDirect
Biological processmRNA splicing0.0001405InformativeDirect
Cellular componentNucleus1.383e-11Least InformativeDirect
Cellular componentCytoplasm2.382e-07Least InformativeDirect
Cellular componentMembrane0.0005405Least InformativeDirect
Cellular componentCytoskeleton6.009e-05Moderately InformativeDirect
Cellular componentCell junction0.007189Moderately InformativeInherited
Cellular componentSynapse0.06202InformativeInherited
Cellular componentPostsynaptic cell membrane1.828e-05Highly InformativeDirect
Coding sequence diversityPolymorphism0.0005873Moderately InformativeDirect
DiseaseDisease mutation0.0009948Least InformativeDirect
DiseaseAmyloidosis6.638e-08Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0.9815Least InformativeInherited
DomainANK repeat0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainImmunoglobulin domain1.61e-08InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease5.2e-12Moderately InformativeDirect
Post-translational modificationActivator0.0006635Moderately InformativeDirect
Post-translational modificationKinase0.1301Moderately InformativeInherited
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase1.353e-09InformativeDirect
Post-translational modificationPhosphoprotein8.324e-13Least InformativeDirect
Post-translational modificationUbl conjugation2.04e-08Moderately InformativeDirect
Post-translational modificationZymogen7.93e-12InformativeDirect
Post-translational modificationHydroxylation0.0001707InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011029 SSF47986 Protein matches
Abstract

The death domain (DD) is a conserved region of about 80 residues found on death receptors, and which is required for death signalling, as well as a variety of non-apoptotic functions [PubMed11828422, PubMed12655292]. Proteins containing this domain include the low affinity neurotrophin receptor p73, Fas, FADD (Fas-associated death domain protein), TNF-1 (tumour necrosis factor receptor-1), Pelle protein kinase, and the Tube adaptor protein [PubMed15226512].

The induction of apoptosis also relies on the presence of a second domain, called the death effector domain. The death effector domain (DED) occurs in proteins that regulate programmed cell death, including both pro- and anti-apoptotic proteins; many of these proteins are also involved in controlling cellular activation and proliferation pathways [PubMed12719729]. Proteins containing this domain include FADD (DED N-terminal, DD C-terminal), PEA-15 (phosphoproteins enriched in astrocytes 15kDa), caspases and FLIP.

The induction of apoptosis results in the activation of caspases, a family of aspartyl-specific cysteine proteases that are the main executioners of apoptosis. For example, the DED of FADD recruits two DED-containing caspases, caspase-8 and caspase-10, to form the death-inducing signal complex, which initiates apoptosis. Proteins containing the caspase recruitment domain (CARD) are involved in the recruitment and activation of caspases during apoptosis [PubMed12101092]. Other CARD proteins participate in NF-kappaB signalling pathways associated with innate or adaptive immune responses. Proteins containing CARD include Raidd, APAF-1 (apoptotic protease activating factor 1), procaspase 9 and iceberg (inhibitor of interleukin-1-beta generation).

The DD shows strong structural similarity to both DED and CARD. They all display a 6-helical closed bundle fold, with greek key topology and an internal psuedo two-fold symmetry. However, despite their overall similarity in topology, each domain forms specialised interactions, typically only with members of its own subfamily, for example DED with DED.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DEATH domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the DEATH domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]