SUPERFAMILY 1.75 HMM library and genome assignments server

DEATH domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DEATH domain [ 47985]
Superfamily:   DEATH domain [ 47986] (4)
Families:   DEATH domain, DD [ 81312] (8)
  DEATH effector domain, DED [ 81388] (2)
  Caspase recruitment domain, CARD [ 81313] (5)
  Pyrin domain, PYD [ 101298] (2)


Superfamily statistics
Genomes (141) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,881 9,865 25
Proteins 8,717 8,797 25


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)positive regulation of biological process0.0000000007970Least InformativeDirect
Biological Process (BP)response to stimulus0.00000019870Least InformativeDirect
Biological Process (BP)regulation of cellular process0.00000059360.0001814Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.72111Least InformativeInherited
Biological Process (BP)single-organism cellular process0.36160Least InformativeInherited
Biological Process (BP)developmental process0.076260Least InformativeInherited
Biological Process (BP)positive regulation of cellular process0.000000000077470Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.000012850.00000000003706Moderately InformativeDirect
Biological Process (BP)defense response0.000080280Moderately InformativeDirect
Biological Process (BP)regulation of localization0.00012810.0000000001254Moderately InformativeDirect
Biological Process (BP)regulation of gene expression0.00052870.0005865Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0025231Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.0019861Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.088061Moderately InformativeInherited
Biological Process (BP)cell differentiation0.0047840.01991Moderately InformativeInherited
Biological Process (BP)regulation of phosphorus metabolic process0.0005980.01768Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.0000067771Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.098110Moderately InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.0000064190.00000000000001071InformativeDirect
Biological Process (BP)regulation of cytokine production0.000010460InformativeDirect
Biological Process (BP)regulation of apoptotic process0.00028130.0001068InformativeDirect
Biological Process (BP)regulation of secretion0.032230.0336InformativeInherited
Biological Process (BP)regulation of protein localization0.0080310.01743InformativeInherited
Biological Process (BP)positive regulation of transport0.00015940.007482InformativeInherited
Biological Process (BP)positive regulation of cell death0.039910InformativeInherited
Biological Process (BP)regulation of interleukin-1 beta production0.000000000000041990Highly InformativeDirect
Biological Process (BP)positive regulation of protein secretion0.0000000000043260.0000000004857Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production0.000083720Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion0.0032590.003353Highly InformativeInherited
Molecular Function (MF)binding0.00013950Least InformativeDirect
Molecular Function (MF)nucleic acid binding0.00025781Moderately InformativeInherited
Molecular Function (MF)DNA binding0.000013240.5867InformativeInherited
Molecular Function (MF)structure-specific DNA binding0.000000062170.05965Highly InformativeInherited
Cellular Component (CC)protein complex0.00060270Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) positive regulation of biological process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0001814 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00000000000001414 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000003706 Moderately Informative Direct
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0000000001254 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0005865 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0000000008813 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0000000107 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00000843 Moderately Informative Direct
Biological Process (BP) gene expression 0.00009449 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0008862 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.3174 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01709 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1959 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.7794 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2269 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.004666 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2805 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.01991 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.01768 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.6413 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.1343 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.003136 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.03148 Moderately Informative Inherited
Biological Process (BP) reproductive process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.00000000000001071 Informative Direct
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0001068 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) immune response 0.000000000000003707 Informative Direct
Biological Process (BP) positive regulation of cell death 0 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0 Informative Direct
Biological Process (BP) regulation of defense response 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) protein maturation 0 Informative Direct
Biological Process (BP) regulation of cell activation 0 Informative Direct
Biological Process (BP) response to bacterium 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) locomotion 0.0000000000001622 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0000000000007117 Informative Direct
Biological Process (BP) protein oligomerization 0.00000000002868 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.00000000004362 Informative Direct
Biological Process (BP) cell projection organization 0.0000000003227 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000003269 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00000006193 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0.0000003538 Informative Direct
Biological Process (BP) regulation of locomotion 0.0000007321 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0000008613 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000001672 Informative Direct
Biological Process (BP) blood circulation 0.00001052 Informative Direct
Biological Process (BP) positive regulation of intracellular signal transduction 0.00001061 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00002225 Informative Direct
Biological Process (BP) protein transport 0.00003478 Informative Direct
Biological Process (BP) regulation of MAPK cascade 0.00005217 Informative Direct
Biological Process (BP) gland development 0.00008531 Informative Direct
Biological Process (BP) muscle system process 0.0002943 Informative Direct
Biological Process (BP) cellular component movement 0.0003593 Informative Direct
Biological Process (BP) regulation of immune effector process 0.0006074 Informative Direct
Biological Process (BP) regulation of nervous system development 0.1296 Informative Inherited
Biological Process (BP) regulation of cell development 0.6748 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.0336 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.002113 Informative Inherited
Biological Process (BP) apoptotic process 0.03178 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.09286 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.002128 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.1156 Informative Inherited
Biological Process (BP) cellular response to external stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.8027 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.0121 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.07825 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.3694 Informative Inherited
Biological Process (BP) epithelium development 0.03101 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.2681 Informative Inherited
Biological Process (BP) cation homeostasis 0.02128 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.01743 Informative Inherited
Biological Process (BP) positive regulation of transport 0.007482 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.00751 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.7503 Informative Inherited
Biological Process (BP) regulation of response to wounding 0.03455 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) phosphorylation 0.02484 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.07057 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.5408 Informative Inherited
Biological Process (BP) regulation of growth 0.2854 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) defense response to other organism 0.0106 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.0468 Informative Inherited
Biological Process (BP) localization of cell 0.7329 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.9191 Informative Inherited
Biological Process (BP) muscle structure development 0.3215 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6802 Informative Inherited
Biological Process (BP) response to nutrient levels 0.5235 Informative Inherited
Biological Process (BP) response to lipid 0.006191 Informative Inherited
Biological Process (BP) leukocyte activation 0.4323 Informative Inherited
Biological Process (BP) central nervous system development 0.344 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.2187 Informative Inherited
Biological Process (BP) secretion by cell 0.7716 Informative Inherited
Biological Process (BP) single-organism behavior 0.4032 Informative Inherited
Biological Process (BP) neurological system process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.01198 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.9404 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.5262 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.0651 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.8707 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) multi-multicellular organism process 1 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.6635 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) tube development 0.7958 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.01109 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of interleukin-1 beta production 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.0000000004857 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.000000008754 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) execution phase of apoptosis 0 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000000000000003707 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0.00000000000001071 Highly Informative Direct
Biological Process (BP) regulation of ion transmembrane transport 0.00000000000001752 Highly Informative Direct
Biological Process (BP) heart contraction 0.0000000000005654 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.000000000001327 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0.000000000001776 Highly Informative Direct
Biological Process (BP) striated muscle contraction 0.000000000002446 Highly Informative Direct
Biological Process (BP) zymogen activation 0.00000000003363 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0000000003837 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.000000001192 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.000000003923 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.000000004059 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.0000000117 Highly Informative Direct
Biological Process (BP) hair cycle process 0.00000001421 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00000001777 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.00000006887 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 0.00000009104 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.0000001102 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0000002484 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000000326 Highly Informative Direct
Biological Process (BP) learning or memory 0.000002855 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.00000563 Highly Informative Direct
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.000006651 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response 0.0000108 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte migration 0.00003572 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.00003721 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0.0000718 Highly Informative Direct
Biological Process (BP) regulation of protein targeting 0.0001057 Highly Informative Direct
Biological Process (BP) myeloid cell development 0.0001725 Highly Informative Direct
Biological Process (BP) negative regulation of protein catabolic process 0.0001853 Highly Informative Direct
Biological Process (BP) response to UV 0.0002933 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0003243 Highly Informative Direct
Biological Process (BP) defense response to bacterium 0.000329 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.000439 Highly Informative Direct
Biological Process (BP) T cell differentiation 0.0004503 Highly Informative Direct
Biological Process (BP) positive regulation of protein modification by small protein conjugation or removal 0.0008484 Highly Informative Direct
Biological Process (BP) epithelial tube formation 0.0009195 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.3603 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.4551 Highly Informative Inherited
Biological Process (BP) epithelial cell development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.05844 Highly Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0.2501 Highly Informative Inherited
Biological Process (BP) regulation of chemotaxis 1 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.6906 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.1493 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.00234 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 1 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.1221 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.02037 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.003201 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.003353 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.0172 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.6212 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.01713 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.001921 Highly Informative Inherited
Biological Process (BP) placenta development 0.07016 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02004 Highly Informative Inherited
Biological Process (BP) ensheathment of neurons 0.01538 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.1398 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.7479 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.9493 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.001347 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.2152 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.09037 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-templated 1 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.01659 Highly Informative Inherited
Biological Process (BP) sensory perception 0.01346 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.1468 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.402 Highly Informative Inherited
Biological Process (BP) icosanoid metabolic process 0.001607 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.004723 Highly Informative Inherited
Biological Process (BP) negative regulation of response to wounding 0.007844 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.1254 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.2769 Highly Informative Inherited
Biological Process (BP) negative regulation of defense response 0.8928 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.003547 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.4839 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.01195 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.002437 Highly Informative Inherited
Biological Process (BP) response to fungus 0.6954 Highly Informative Inherited
Biological Process (BP) positive regulation of production of molecular mediator of immune response 0.7243 Highly Informative Inherited
Biological Process (BP) epidermis development 0.06575 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte mediated immunity 0.007526 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated cytotoxicity 0.03024 Highly Informative Inherited
Biological Process (BP) neural tube development 0.001994 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.003941 Least Informative Inherited
Molecular Function (MF) transferase activity 0.8448 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.00004345 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00374 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.00000000001941 Informative Direct
Molecular Function (MF) receptor activity 0.000007211 Informative Direct
Molecular Function (MF) molecular transducer activity 0.000008185 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.00007653 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0002267 Informative Direct
Molecular Function (MF) kinase activity 0.000239 Informative Direct
Molecular Function (MF) enzyme binding 0.0007782 Informative Direct
Molecular Function (MF) amide binding 0.009345 Informative Inherited
Molecular Function (MF) receptor binding 0.4265 Informative Inherited
Molecular Function (MF) DNA binding 0.5867 Informative Inherited
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00000000007409 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.00000000016 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 0.0000000002326 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.000000000499 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.00000001819 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.000004567 Highly Informative Direct
Molecular Function (MF) peptide binding 0.00001426 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.00002531 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.8838 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.2259 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.07077 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 0.05965 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.000164 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000008776 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000000004338 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.000003781 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.0001424 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.1302 Moderately Informative Inherited
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) contractile fiber part 0.00005281 Informative Direct
Cellular Component (CC) cell junction 0.00006896 Informative Direct
Cellular Component (CC) integral component of membrane 1 Informative Inherited
Cellular Component (CC) neuron projection 0.00242 Informative Inherited
Cellular Component (CC) cell-cell contact zone 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00006283 Highly Informative Direct
Cellular Component (CC) receptor complex 0.08899 Highly Informative Inherited
Cellular Component (CC) main axon 0.001775 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.06344 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.05614Least InformativeInherited
Disease Ontology (DO)connective tissue disease0.003192Moderately InformativeInherited
Disease Ontology (DO)syndrome0.04052Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.9848Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000001253InformativeDirect
Disease Ontology (DO)arthropathy0.01522InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.03207InformativeInherited
Disease Ontology (DO)viral infectious disease1InformativeInherited
Disease Ontology (DO)irritable bowel syndrome0.00001074Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.2385Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.3783Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.787Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.7879Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.002352Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.005298Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.145Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.6229Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.6633Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.0000003942InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the spleen0.0004608InformativeDirect
Phenotypic Abnormality (PA)Visceromegaly0.002475InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.004708InformativeInherited
Phenotypic Abnormality (PA)Abnormality of leukocytes0.06816InformativeInherited
Phenotypic Abnormality (PA)Vasculitis0.00000002389Highly InformativeDirect
Phenotypic Abnormality (PA)Lymphadenopathy0.0000007304Highly InformativeDirect
Phenotypic Abnormality (PA)Leukocytosis0.00001488Highly InformativeDirect
Phenotypic Abnormality (PA)Episodic fever0.00002424Highly InformativeDirect
Phenotypic Abnormality (PA)Elevated erythrocyte sedimentation rate0.00002625Highly InformativeDirect
Phenotypic Abnormality (PA)Increased IgM level0.00009769Highly InformativeDirect
Phenotypic Abnormality (PA)Amyloidosis0.0001131Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0001916Highly InformativeDirect
Phenotypic Abnormality (PA)Arthralgia0.0005109Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pericardium0.0005476Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of T cell physiology0.0005476Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the peritoneum0.0008595Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.0000002491Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0000007287Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0000786Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.2374Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4803Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.00000000001416Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.0000006609Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0000009165Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.0005792Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.0007019Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0.001031Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.002191Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01155Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.08633Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.1018Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1421Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.3097Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.4834Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.0002829InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.000338InformativeDirect
Mammalian Phenotype (MP)abnormal phagocyte morphology0.0003748InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.001523InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.01194InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.01283InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.02275InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.1215InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.1636InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.1981InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2246InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.3054InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.3673InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.7252InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8425InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.8934InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.00000000008105Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.0000002771Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes0.00000144Highly InformativeDirect
Mammalian Phenotype (MP)decreased interferon-alpha secretion0.000003178Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spleen germinal center morphology0.00002707Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gut flora balance0.00006613Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.00008105Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis0.0001036Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.0001407Highly InformativeDirect
Mammalian Phenotype (MP)abnormal acute inflammation0.0002809Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell proliferation0.0004386Highly InformativeDirect
Mammalian Phenotype (MP)decreased inflammatory response0.0004808Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-6 secretion0.06368Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0001952Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.003962Least InformativeInherited
Worm Phenotype (WP)cell death variant0.05475Moderately InformativeInherited
Worm Phenotype (WP)cell corpse number variant0.00004879InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0001888InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)immune response defective0.0008678Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0000002484Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.00001342Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.000443InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0000003838Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0Least InformativeDirect
Drugbank ATC_code (DB)stomatological preparations0Moderately InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0.000009623Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0.000000000001366InformativeDirect
Biological processBiological rhythms0.000000001549InformativeDirect
Biological processmRNA splicing0.0001428InformativeDirect
Cellular componentNucleus0.00000000001466Least InformativeDirect
Cellular componentCytoplasm0.0000002337Least InformativeDirect
Cellular componentMembrane0.00056Least InformativeDirect
Cellular componentCytoskeleton0.00006139Moderately InformativeDirect
Cellular componentCell junction0.007212Moderately InformativeInherited
Cellular componentSynapse0.06242InformativeInherited
Cellular componentPostsynaptic cell membrane0.00001825Highly InformativeDirect
Coding sequence diversityPolymorphism0.0005859Moderately InformativeDirect
DiseaseAmyloidosis0.00000008887Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0.9795Least InformativeInherited
DomainANK repeat0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainImmunoglobulin domain0.00000001579InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease0.000000000005135Moderately InformativeDirect
Post-translational modificationActivator0.0006637Moderately InformativeDirect
Post-translational modificationKinase0.1306Moderately InformativeInherited
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.000000001363InformativeDirect
Post-translational modificationPhosphoprotein0.0000000000008965Least InformativeDirect
Post-translational modificationUbl conjugation0.00000002308Moderately InformativeDirect
Post-translational modificationZymogen0.000000000007671InformativeDirect
Post-translational modificationHydroxylation0.000169InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011029 SSF47986 Protein matches
Abstract

The death domain (DD) is a conserved region of about 80 residues found on death receptors, and which is required for death signalling, as well as a variety of non-apoptotic functions [PubMed11828422, PubMed12655292]. Proteins containing this domain include the low affinity neurotrophin receptor p73, Fas, FADD (Fas-associated death domain protein), TNF-1 (tumour necrosis factor receptor-1), Pelle protein kinase, and the Tube adaptor protein [PubMed15226512].

The induction of apoptosis also relies on the presence of a second domain, called the death effector domain. The death effector domain (DED) occurs in proteins that regulate programmed cell death, including both pro- and anti-apoptotic proteins; many of these proteins are also involved in controlling cellular activation and proliferation pathways [PubMed12719729]. Proteins containing this domain include FADD (DED N-terminal, DD C-terminal), PEA-15 (phosphoproteins enriched in astrocytes 15kDa), caspases and FLIP.

The induction of apoptosis results in the activation of caspases, a family of aspartyl-specific cysteine proteases that are the main executioners of apoptosis. For example, the DED of FADD recruits two DED-containing caspases, caspase-8 and caspase-10, to form the death-inducing signal complex, which initiates apoptosis. Proteins containing the caspase recruitment domain (CARD) are involved in the recruitment and activation of caspases during apoptosis [PubMed12101092]. Other CARD proteins participate in NF-kappaB signalling pathways associated with innate or adaptive immune responses. Proteins containing CARD include Raidd, APAF-1 (apoptotic protease activating factor 1), procaspase 9 and iceberg (inhibitor of interleukin-1-beta generation).

The DD shows strong structural similarity to both DED and CARD. They all display a 6-helical closed bundle fold, with greek key topology and an internal psuedo two-fold symmetry. However, despite their overall similarity in topology, each domain forms specialised interactions, typically only with members of its own subfamily, for example DED with DED.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DEATH domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the DEATH domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]