SUPERFAMILY 1.75 HMM library and genome assignments server

Cyclin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cyclin-like [ 47953]
Superfamily:   Cyclin-like [ 47954] (3)
Families:   Cyclin [ 47955] (8)
  Transcription factor IIB (TFIIB), core domain [ 47965]
  Retinoblastoma tumor suppressor domains [ 47969]


Superfamily statistics
Genomes (718) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,678 28,397 69
Proteins 15,878 17,576 37


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00029940.00002046Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.59530.0002005Least InformativeInherited
Biological Process (BP)single-organism cellular process0.59110.02509Least InformativeInherited
Biological Process (BP)regulation of phosphorus metabolic process0.00045750Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00088020Moderately InformativeDirect
Biological Process (BP)immune system process0.0021420.5669Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0010460Moderately InformativeInherited
Biological Process (BP)cell proliferation0.0000087330.00000001214InformativeDirect
Biological Process (BP)regulation of transferase activity0.000014540InformativeDirect
Biological Process (BP)regulation of protein phosphorylation0.00003660InformativeDirect
Biological Process (BP)leukocyte activation0.0000033750.004924InformativeInherited
Biological Process (BP)leukocyte proliferation0.0000000067760.001275Highly InformativeInherited
Molecular Function (MF)transferase activity0.0048580.05314Least InformativeInherited
Molecular Function (MF)binding0.014540.00000000007644Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.000035280.00000001642Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.000190Moderately InformativeDirect
Molecular Function (MF)kinase activity0.000013490.0000000001285InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.0000035780.8401InformativeInherited
Molecular Function (MF)protein kinase regulator activity0.000000013370Highly InformativeDirect
Molecular Function (MF)protein kinase activity0.0000008410.2967Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.00002046 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0002005 Least Informative Direct
Biological Process (BP) developmental process 0.000000000001176 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0000000004257 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0000000008734 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000001464 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000001722 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000002941 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000001045 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.000003272 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.04904 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.02509 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.08353 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.007522 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0000001252 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0000002722 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0000004414 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00001349 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00006162 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0009435 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.752 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8396 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9373 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.8974 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.02271 Moderately Informative Inherited
Biological Process (BP) organ development 0.5069 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.5669 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.9513 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8108 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.9791 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.16 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.01865 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.002936 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.06639 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.02531 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.02668 Moderately Informative Inherited
Biological Process (BP) gene expression 0.04946 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8065 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cell proliferation 0.00000001214 Informative Direct
Biological Process (BP) regulation of transferase activity 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) phosphorylation 0.0000000006997 Informative Direct
Biological Process (BP) cell division 0.000000001156 Informative Direct
Biological Process (BP) organelle fission 0.000000004523 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.000000008657 Informative Direct
Biological Process (BP) mitotic cell cycle 0.00000002373 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0001447 Informative Direct
Biological Process (BP) epithelium development 0.0001954 Informative Direct
Biological Process (BP) chromosome organization 0.05097 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) apoptotic process 0.1881 Informative Inherited
Biological Process (BP) positive regulation of transport 0.8436 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.2562 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1365 Informative Inherited
Biological Process (BP) regulation of protein localization 0.0116 Informative Inherited
Biological Process (BP) response to light stimulus 0.1635 Informative Inherited
Biological Process (BP) regulation of growth 0.06648 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.3212 Informative Inherited
Biological Process (BP) regulation of cell development 0.5308 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.4585 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.6063 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) muscle structure development 0.7212 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 1 Informative Inherited
Biological Process (BP) proteolysis 0.353 Informative Inherited
Biological Process (BP) leukocyte activation 0.004924 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.5227 Informative Inherited
Biological Process (BP) response to lipid 0.312 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.4765 Informative Inherited
Biological Process (BP) protein catabolic process 0.02505 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.911 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.009631 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 0.4964 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.8557 Informative Inherited
Biological Process (BP) localization of cell 0.2708 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.08414 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.06344 Informative Inherited
Biological Process (BP) reproductive structure development 0.8606 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.8435 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.1652 Informative Inherited
Biological Process (BP) generation of neurons 0.4218 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.3834 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2698 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.4937 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.79 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.006583 Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0 Highly Informative Direct
Biological Process (BP) epidermis development 0 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0000000000145 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 0.0000000004222 Highly Informative Direct
Biological Process (BP) DNA replication 0.0000000006081 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.0000000007058 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.00000003051 Highly Informative Direct
Biological Process (BP) response to UV 0.00000004092 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.00000009995 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.00002294 Highly Informative Direct
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.000124 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.0007426 Highly Informative Direct
Biological Process (BP) in utero embryonic development 0.0007658 Highly Informative Direct
Biological Process (BP) histone modification 0.001103 Highly Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0.001248 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.006674 Highly Informative Inherited
Biological Process (BP) regulation of protein targeting 0.003876 Highly Informative Inherited
Biological Process (BP) protein methylation 0.03165 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01607 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.06037 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.9879 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.006002 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 1 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.08519 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.001275 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.1525 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.001688 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.02961 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.002791 Highly Informative Inherited
Biological Process (BP) negative regulation of cell growth 0.1127 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.01741 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.1532 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.0737 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.1493 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1253 Highly Informative Inherited
Biological Process (BP) germ cell development 0.1783 Highly Informative Inherited
Biological Process (BP) cytokinesis 1 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.08302 Highly Informative Inherited
Biological Process (BP) DNA integrity checkpoint 0.05292 Highly Informative Inherited
Molecular Function (MF) binding 0.00000000007644 Least Informative Direct
Molecular Function (MF) transferase activity 0.05314 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00000001642 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0.0000000001285 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.8401 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.008131 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0 Highly Informative Direct
Molecular Function (MF) kinase binding 0.00000001073 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.00005544 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.2967 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.000001152 Least Informative Direct
Cellular Component (CC) protein complex 0.0000001288 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.09994 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.000002678 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.007362 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.01862 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.00000001255 Informative Direct
Cellular Component (CC) DNA-directed RNA polymerase complex 0.0000002343 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.00001243 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.01859 Informative Inherited
Cellular Component (CC) microtubule organizing center 0.000003031 Highly Informative Direct
Cellular Component (CC) spindle 0.0001574 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1709Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.001034Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.005296Moderately InformativeInherited
Disease Ontology (DO)laryngeal carcinoma0.000004141InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0.0008344InformativeDirect
Disease Ontology (DO)retinal cancer0.000000001125Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.1033Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.132Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1421Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1594Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.2505Least InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.002561Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.05596Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.08636Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.08865Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1018Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.1563Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.3394Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.364Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.7246Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.7588Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.7855Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.0000621InformativeDirect
Mammalian Phenotype (MP)ectopic neuron0.0008475InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.001603InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.006237InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.009781InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.02146InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.04995InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.08188InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1049InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.2152InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.287InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.4987InformativeInherited
Mammalian Phenotype (MP)abnormal hindbrain development0.00001396Highly InformativeDirect
Mammalian Phenotype (MP)decreased retinal ganglion cell number0.0001366Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hematopoietic stem cell morphology0.0003158Highly InformativeDirect
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.0003679Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vitelline vasculature morphology0.0005172Highly InformativeDirect
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number0.0005557Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal apoptosis0.000714Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0.002218Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0006357Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.4248Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0001521Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0006089Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.0318Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.05913Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.2964Moderately InformativeInherited
Worm Phenotype (WP)pigmentation variant0.0004092InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0004092InformativeDirect
Worm Phenotype (WP)chromosome segregation variant0.0009942InformativeDirect
Worm Phenotype (WP)protein expression variant0.001456InformativeInherited
Worm Phenotype (WP)cell division variant0.01035InformativeInherited
Worm Phenotype (WP)nuclear number variant0.0000003309Highly InformativeDirect
Worm Phenotype (WP)embryonic cell morphology variant0.0000007446Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0001548Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.1624Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.03886Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.0002123InformativeDirect
Yeast Phenotype (YP)budding0.02642Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective0.00002775InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.0001644Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processTranscription regulation0.00000000000001631Moderately InformativeDirect
Biological processMitosis0.00000000000001002InformativeDirect
Biological processMeiosis0.00000009165InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.0001201Moderately InformativeDirect
DiseaseTumor suppressor0.000001888Moderately InformativeDirect
DomainRepeat0.000000000003679Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionZinc0.0000002163Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationChromatin regulator0.0003966InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationMyristate0.0003294InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011028 SSF47954 Protein matches
Abstract

This domain is also found as the core domain in transcription factor IIB (TFIIB) and in the retinoblastoma tumour suppressor.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cyclin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the Cyclin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]