SUPERFAMILY 1.75 HMM library and genome assignments server


Cyclin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cyclin-like [ 47953]
Superfamily:   Cyclin-like [ 47954] (3)
Families:   Cyclin [ 47955] (8)
  Transcription factor IIB (TFIIB), core domain [ 47965]
  Retinoblastoma tumor suppressor domains [ 47969]


Superfamily statistics
Genomes (717) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,639 28,397 69
Proteins 15,851 17,576 37


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00024525.572e-06Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.55730.0001427Least InformativeInherited
Biological Process (BP)single-organism cellular process0.3438.315e-08Least InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.00043140Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00091230Moderately InformativeDirect
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)immune system process0.0021840.5811Moderately InformativeInherited
Biological Process (BP)regulation of kinase activity7.675e-061.762e-11InformativeDirect
Biological Process (BP)regulation of protein phosphorylation3.348e-051.539e-10InformativeDirect
Biological Process (BP)leukocyte activation3.41e-060.004971InformativeInherited
Biological Process (BP)leukocyte proliferation6.819e-090.001427Highly InformativeInherited
Molecular Function (MF)transferase activity0.0037920.01125Least InformativeInherited
Molecular Function (MF)binding0.013982.932e-11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups3.458e-051.686e-08Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.00028870Moderately InformativeDirect
Molecular Function (MF)kinase activity1.352e-051.414e-10InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor3.457e-060.8392InformativeInherited
Molecular Function (MF)protein kinase regulator activity1.339e-080Highly InformativeDirect
Molecular Function (MF)protein kinase activity8.458e-070.3036Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 5.572e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 8.315e-08 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0001427 Least Informative Direct
Biological Process (BP) developmental process 4.558e-13 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 9.411e-11 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 2.006e-10 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 4.635e-09 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.255e-08 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.842e-07 Least Informative Direct
Biological Process (BP) biosynthetic process 1.001e-06 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1.042e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.03193 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.04796 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.07785 Least Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 1.087e-07 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 2.266e-07 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 3.593e-07 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 1.212e-05 Moderately Informative Direct
Biological Process (BP) cellular response to stress 4.518e-05 Moderately Informative Direct
Biological Process (BP) reproduction 6.273e-05 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0009675 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.01392 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.9213 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.9313 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.5811 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7912 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.9732 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5512 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.4364 Moderately Informative Inherited
Biological Process (BP) organ development 0.2679 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6098 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.09792 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4672 Moderately Informative Inherited
Biological Process (BP) tissue development 0.03133 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01074 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.01528 Moderately Informative Inherited
Biological Process (BP) gene expression 0.01904 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of kinase activity 1.762e-11 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 1.539e-10 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) phosphorylation 1.721e-11 Informative Direct
Biological Process (BP) DNA metabolic process 1.586e-10 Informative Direct
Biological Process (BP) mitotic cell cycle 8.196e-10 Informative Direct
Biological Process (BP) transcription, DNA-dependent 3.896e-08 Informative Direct
Biological Process (BP) response to DNA damage stimulus 6.284e-06 Informative Direct
Biological Process (BP) apoptotic process 0.1882 Informative Inherited
Biological Process (BP) positive regulation of transport 0.874 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1445 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.1701 Informative Inherited
Biological Process (BP) chromosome organization 0.01154 Informative Inherited
Biological Process (BP) regulation of growth 0.08173 Informative Inherited
Biological Process (BP) generation of neurons 0.4114 Informative Inherited
Biological Process (BP) regulation of cell development 0.6519 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.8968 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9679 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1296 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.4758 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 1 Informative Inherited
Biological Process (BP) muscle structure development 0.9438 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.5095 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.4932 Informative Inherited
Biological Process (BP) leukocyte activation 0.004971 Informative Inherited
Biological Process (BP) response to lipid 0.2948 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.466 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.6349 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.3536 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.8512 Informative Inherited
Biological Process (BP) localization of cell 0.2648 Informative Inherited
Biological Process (BP) locomotion 0.5097 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.1586 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.03442 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7275 Informative Inherited
Biological Process (BP) protein catabolic process 0.02457 Informative Inherited
Biological Process (BP) proteolysis 0.3502 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.3874 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.01062 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.4928 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.7287 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8832 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.005247 Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0 Highly Informative Direct
Biological Process (BP) cell cycle phase 0 Highly Informative Direct
Biological Process (BP) post-embryonic development 2.223e-11 Highly Informative Direct
Biological Process (BP) DNA damage checkpoint 4.377e-11 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 3.293e-10 Highly Informative Direct
Biological Process (BP) DNA replication 1.397e-09 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 4.159e-09 Highly Informative Direct
Biological Process (BP) response to UV 2.992e-08 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 3.766e-08 Highly Informative Direct
Biological Process (BP) protein phosphorylation 4.114e-07 Highly Informative Direct
Biological Process (BP) developmental maturation 3.648e-06 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 1.61e-05 Highly Informative Direct
Biological Process (BP) cell division 5.535e-05 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.0006243 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.05926 Highly Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0.001078 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.004347 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.01441 Highly Informative Inherited
Biological Process (BP) protein methylation 0.02976 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.00171 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01592 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.02255 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.9139 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.001427 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.08821 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.1452 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.001935 Highly Informative Inherited
Biological Process (BP) negative regulation of cell growth 0.1414 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.01422 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.1202 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1237 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.7383 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.1383 Highly Informative Inherited
Molecular Function (MF) binding 2.932e-11 Least Informative Direct
Molecular Function (MF) transferase activity 0.01125 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1.686e-08 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 1.414e-10 Informative Direct
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.007471 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.8392 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0 Highly Informative Direct
Molecular Function (MF) kinase binding 1.035e-08 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 8.66e-08 Highly Informative Direct
Molecular Function (MF) transcription factor binding 6.105e-05 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.3036 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 8.685e-06 Least Informative Direct
Cellular Component (CC) protein complex 9.258e-09 Least Informative Direct
Cellular Component (CC) intracellular organelle part 5.177e-05 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 4.848e-13 Moderately Informative Direct
Cellular Component (CC) nuclear part 2.638e-06 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.00761 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 2.305e-05 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.01305 Informative Inherited
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 0.007012 Informative Inherited
Cellular Component (CC) centrosome 3.961e-06 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0.0002014 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.1124Least InformativeInherited
Disease Ontology (DO)organ system cancer0.1665Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.0009002Moderately InformativeDirect
Disease Ontology (DO)sensory system disease0.001966Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.005126Moderately InformativeInherited
Disease Ontology (DO)laryngeal carcinoma4.117e-06InformativeDirect
Disease Ontology (DO)retinal disease6.087e-05InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0.0008218InformativeDirect
Disease Ontology (DO)retinal cancer1.116e-09Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0998Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1278Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.14Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1521Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.2492Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.05447Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.08322Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.08467Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.09799Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.1533Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.3379Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.3722Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.7145Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.7412Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.7826Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence0.939Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)ectopic neuron0.0007707InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.001466InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.006164InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.009334InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.02226InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.05002InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.08038InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.09784InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.2124InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.4885InformativeInherited
Mammalian Phenotype (MP)decreased retinal ganglion cell number0.0001108Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hematopoietic stem cell morphology0.0003308Highly InformativeDirect
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.0003498Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vitelline vasculature morphology0.0005025Highly InformativeDirect
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number0.0005528Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal apoptosis0.0005788Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0.002166Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0006357Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.4248Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0001521Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0006089Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.0318Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.05913Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.2964Moderately InformativeInherited
Worm Phenotype (WP)pigmentation variant0.0004092InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0004092InformativeDirect
Worm Phenotype (WP)chromosome segregation variant0.0009942InformativeDirect
Worm Phenotype (WP)protein expression variant0.001456InformativeInherited
Worm Phenotype (WP)cell division variant0.01035InformativeInherited
Worm Phenotype (WP)nuclear number variant3.309e-07Highly InformativeDirect
Worm Phenotype (WP)embryonic cell morphology variant7.446e-07Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0001548Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.1624Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.03883Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.0002122InformativeDirect
Yeast Phenotype (YP)budding0.02639Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective2.78e-05InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.0001614Least InformativeDirect
Xenopus ANatomical entity (XAN)zygote0.001454Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processTranscription regulation1.516e-14Moderately InformativeDirect
Biological processMitosis1.226e-14InformativeDirect
Biological processMeiosis8.536e-08InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.000112Moderately InformativeDirect
DiseaseTumor suppressor8.095e-07Moderately InformativeDirect
DomainRepeat2.641e-12Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionZinc1.417e-07Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationChromatin regulator0.0003599InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationMyristate0.0003119InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011028 SSF47954 Protein matches
Abstract

This domain is also found as the core domain in transcription factor IIB (TFIIB) and in the retinoblastoma tumour suppressor.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cyclin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the Cyclin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]