SUPERFAMILY 1.75 HMM library and genome assignments server


Cyclin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cyclin-like [ 47953]
Superfamily:   Cyclin-like [ 47954] (3)
Families:   Cyclin [ 47955] (8)
  Transcription factor IIB (TFIIB), core domain [ 47965]
  Retinoblastoma tumor suppressor domains [ 47969]


Superfamily statistics
Genomes (717) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,639 28,397 69
Proteins 15,851 17,576 37


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.0002286.844e-06Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.55510.0001771Least InformativeInherited
Biological Process (BP)single-organism cellular process0.33361.056e-07Least InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.00041130Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00087760Moderately InformativeDirect
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)immune system process0.0021610.5815Moderately InformativeInherited
Biological Process (BP)regulation of kinase activity7.553e-063.542e-11InformativeDirect
Biological Process (BP)regulation of protein phosphorylation3.147e-051.537e-10InformativeDirect
Biological Process (BP)leukocyte activation3.356e-060.005166InformativeInherited
Biological Process (BP)leukocyte proliferation6.758e-090.001369Highly InformativeInherited
Molecular Function (MF)transferase activity0.0034310.01076Least InformativeInherited
Molecular Function (MF)binding0.012593.558e-11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups3.174e-051.808e-08Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.00028740Moderately InformativeDirect
Molecular Function (MF)kinase activity1.246e-051.636e-10InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor3.268e-060.8596InformativeInherited
Molecular Function (MF)protein kinase regulator activity1.309e-080Highly InformativeDirect
Molecular Function (MF)protein kinase activity8.179e-070.3108Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 6.844e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.056e-07 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0001771 Least Informative Direct
Biological Process (BP) developmental process 8.09e-13 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1.024e-10 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 2.118e-10 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 4.774e-09 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.665e-08 Least Informative Direct
Biological Process (BP) multicellular organismal process 5.582e-07 Least Informative Direct
Biological Process (BP) biosynthetic process 8.445e-07 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1.026e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.03141 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.04494 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.08526 Least Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 1.018e-07 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 2.145e-07 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 3.436e-07 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 1.167e-05 Moderately Informative Direct
Biological Process (BP) cellular response to stress 4.207e-05 Moderately Informative Direct
Biological Process (BP) reproduction 6.805e-05 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0009887 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.01296 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.9271 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.9336 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.5815 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7904 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.9687 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5071 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.2653 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5643 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.09126 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4149 Moderately Informative Inherited
Biological Process (BP) tissue development 0.0317 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01054 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.01545 Moderately Informative Inherited
Biological Process (BP) gene expression 0.01932 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of kinase activity 3.542e-11 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 1.537e-10 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) phosphorylation 2.494e-11 Informative Direct
Biological Process (BP) DNA metabolic process 1.469e-10 Informative Direct
Biological Process (BP) mitotic cell cycle 9.356e-10 Informative Direct
Biological Process (BP) transcription, DNA-dependent 3.958e-08 Informative Direct
Biological Process (BP) response to DNA damage stimulus 6.802e-06 Informative Direct
Biological Process (BP) apoptotic process 0.1891 Informative Inherited
Biological Process (BP) positive regulation of transport 0.8794 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.141 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.1691 Informative Inherited
Biological Process (BP) chromosome organization 0.01149 Informative Inherited
Biological Process (BP) regulation of growth 0.07739 Informative Inherited
Biological Process (BP) generation of neurons 0.4128 Informative Inherited
Biological Process (BP) regulation of cell development 0.6561 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.9017 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9739 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1296 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.2343 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.9847 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 1 Informative Inherited
Biological Process (BP) muscle structure development 0.9441 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.4958 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.4943 Informative Inherited
Biological Process (BP) leukocyte activation 0.005166 Informative Inherited
Biological Process (BP) response to lipid 0.2943 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.47 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.6401 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.3493 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.008329 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.8515 Informative Inherited
Biological Process (BP) localization of cell 0.2683 Informative Inherited
Biological Process (BP) locomotion 0.5082 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.1543 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.02826 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.771 Informative Inherited
Biological Process (BP) protein catabolic process 0.02336 Informative Inherited
Biological Process (BP) proteolysis 0.3429 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.3915 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.01153 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.4932 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.7334 Informative Inherited
Biological Process (BP) single organism reproductive process 0.889 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.006746 Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0 Highly Informative Direct
Biological Process (BP) cell cycle phase 0 Highly Informative Direct
Biological Process (BP) post-embryonic development 2.13e-11 Highly Informative Direct
Biological Process (BP) DNA damage checkpoint 4.948e-11 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 3.219e-10 Highly Informative Direct
Biological Process (BP) DNA replication 1.456e-09 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 4.419e-09 Highly Informative Direct
Biological Process (BP) response to UV 2.94e-08 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 9.621e-08 Highly Informative Direct
Biological Process (BP) protein phosphorylation 4.96e-07 Highly Informative Direct
Biological Process (BP) developmental maturation 3.837e-06 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 1.612e-05 Highly Informative Direct
Biological Process (BP) cell division 5.921e-05 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.0006273 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.03556 Highly Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0.001086 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.004377 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.01458 Highly Informative Inherited
Biological Process (BP) histone modification 0.08485 Highly Informative Inherited
Biological Process (BP) protein methylation 0.02983 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.001763 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01744 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.02362 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.9239 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.001369 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 1 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.1472 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.002039 Highly Informative Inherited
Biological Process (BP) negative regulation of cell growth 0.1443 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.01443 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.111 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1253 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.741 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.1408 Highly Informative Inherited
Molecular Function (MF) binding 3.558e-11 Least Informative Direct
Molecular Function (MF) transferase activity 0.01076 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1.808e-08 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 1.636e-10 Informative Direct
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.006677 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.8596 Informative Inherited
Molecular Function (MF) DNA binding 0.4401 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0 Highly Informative Direct
Molecular Function (MF) kinase binding 1.154e-08 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 4.16e-07 Highly Informative Direct
Molecular Function (MF) transcription factor binding 6.057e-05 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.3108 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.004124 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 9.732e-06 Least Informative Direct
Cellular Component (CC) protein complex 9.484e-09 Least Informative Direct
Cellular Component (CC) intracellular organelle part 5.776e-05 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 7.524e-13 Moderately Informative Direct
Cellular Component (CC) nuclear part 3.737e-06 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.006942 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 2.456e-05 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.01229 Informative Inherited
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 0.006555 Informative Inherited
Cellular Component (CC) centrosome 4.014e-06 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0.0001994 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06718Least InformativeInherited
Disease Ontology (DO)nervous system disease0.1068Least InformativeInherited
Disease Ontology (DO)sensory system disease0.0008734Moderately InformativeDirect
Disease Ontology (DO)nervous system cancer0.001627Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.005127Moderately InformativeInherited
Disease Ontology (DO)laryngeal carcinoma3.34e-06InformativeDirect
Disease Ontology (DO)retinal disease3.599e-05InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0.0005655InformativeDirect
Disease Ontology (DO)retinal cancer5.167e-10Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.09979Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1393Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1448Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2266Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.2513Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.03213Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.0382Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.05484Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.08438Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.1528Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.3705Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4063Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.6383Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.7452Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.7795Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence0.9381Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)ectopic neuron0.0007788InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.001464InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.0062InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.0093InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.02205InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.04772InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.05034InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.07991InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.2082InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.4893InformativeInherited
Mammalian Phenotype (MP)decreased retinal ganglion cell number0.0001119Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hematopoietic stem cell morphology0.0003082Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vitelline vasculature morphology0.0004974Highly InformativeDirect
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number0.0005563Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal apoptosis0.0006233Highly InformativeDirect
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.001421Highly InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0.0022Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0006357Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.4248Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0001521Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0006089Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.0318Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.05913Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.2964Moderately InformativeInherited
Worm Phenotype (WP)pigmentation variant0.0004092InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0004092InformativeDirect
Worm Phenotype (WP)chromosome segregation variant0.0009942InformativeDirect
Worm Phenotype (WP)protein expression variant0.001456InformativeInherited
Worm Phenotype (WP)cell division variant0.01035InformativeInherited
Worm Phenotype (WP)nuclear number variant3.309e-07Highly InformativeDirect
Worm Phenotype (WP)embryonic cell morphology variant7.446e-07Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0001548Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.1624Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.03863Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.0002081InformativeDirect
Yeast Phenotype (YP)budding0.02658Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective2.952e-05InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.0001604Least InformativeDirect
Xenopus ANatomical entity (XAN)zygote0.001457Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processTranscription regulation1.516e-14Moderately InformativeDirect
Biological processMitosis1.226e-14InformativeDirect
Biological processMeiosis8.536e-08InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.000112Moderately InformativeDirect
DiseaseTumor suppressor8.095e-07Moderately InformativeDirect
DomainRepeat2.641e-12Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionZinc1.417e-07Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationChromatin regulator0.0003599InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationMyristate0.0003119InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011028 SSF47954 Protein matches
Abstract

This domain is also found as the core domain in transcription factor IIB (TFIIB) and in the retinoblastoma tumour suppressor.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cyclin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the Cyclin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]