SUPERFAMILY 1.75 HMM library and genome assignments server


Cyclin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cyclin-like [ 47953]
Superfamily:   Cyclin-like [ 47954] (3)
Families:   Cyclin [ 47955] (8)
  Transcription factor IIB (TFIIB), core domain [ 47965]
  Retinoblastoma tumor suppressor domains [ 47969]


Superfamily statistics
Genomes (666) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 22,635 20,847 69
Proteins 13,974 12,833 37


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.062662.856e-05Least InformativeInherited
Biological Process (BP)regulation of cell cycle2.898e-050InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 2.856e-05 Least Informative Direct
Biological Process (BP) developmental process 5.636e-13 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.299e-11 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1.892e-09 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 3.938e-09 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.767e-08 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 6.207e-08 Least Informative Direct
Biological Process (BP) biosynthetic process 1.558e-07 Least Informative Direct
Biological Process (BP) regulation of metabolic process 5.465e-06 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 7.793e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 4.008e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.146 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.08525 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.007472 Least Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 7.808e-09 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 1.933e-08 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 3.717e-08 Moderately Informative Direct
Biological Process (BP) cellular response to stress 1.327e-06 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 1.616e-06 Moderately Informative Direct
Biological Process (BP) reproduction 4.855e-05 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0002441 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0006322 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.002246 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.9847 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4816 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9331 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1515 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.5129 Moderately Informative Inherited
Biological Process (BP) organ development 0.1638 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 0.4667 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5722 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.02594 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01163 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.04298 Moderately Informative Inherited
Biological Process (BP) gene expression 0.04111 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell cycle 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) phosphorylation 2.447e-14 Informative Direct
Biological Process (BP) regulation of kinase activity 3.04e-10 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 4.077e-10 Informative Direct
Biological Process (BP) transcription, DNA-dependent 7.181e-08 Informative Direct
Biological Process (BP) DNA metabolic process 1.522e-06 Informative Direct
Biological Process (BP) response to DNA damage stimulus 4.63e-06 Informative Direct
Biological Process (BP) cell death 0.9339 Informative Inherited
Biological Process (BP) positive regulation of transport 0.7293 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1557 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.1484 Informative Inherited
Biological Process (BP) chromosome organization 0.06949 Informative Inherited
Biological Process (BP) regulation of growth 0.03816 Informative Inherited
Biological Process (BP) generation of neurons 0.4356 Informative Inherited
Biological Process (BP) regulation of cell development 0.6521 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.8794 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9637 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1307 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.05573 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) muscle structure development 0.8733 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.7481 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.38 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.08606 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) localization of cell 0.2081 Informative Inherited
Biological Process (BP) locomotion 0.4135 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.2263 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.009679 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.609 Informative Inherited
Biological Process (BP) protein catabolic process 0.06217 Informative Inherited
Biological Process (BP) proteolysis 0.5799 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.5098 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.007174 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3904 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8019 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.003829 Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0 Highly Informative Direct
Biological Process (BP) cell cycle phase 0 Highly Informative Direct
Biological Process (BP) protein phosphorylation 2.788e-11 Highly Informative Direct
Biological Process (BP) DNA replication 2.164e-10 Highly Informative Direct
Biological Process (BP) post-embryonic development 5.031e-10 Highly Informative Direct
Biological Process (BP) response to UV 1.716e-08 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 1.355e-07 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 5.98e-07 Highly Informative Direct
Biological Process (BP) developmental maturation 1.994e-06 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 1.106e-05 Highly Informative Direct
Biological Process (BP) cell division 2.772e-05 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 0.0001243 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.0004119 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0005295 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.0006767 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.04162 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.003184 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.01786 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.0118 Highly Informative Inherited
Biological Process (BP) protein methylation 0.02306 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.001964 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01751 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.02172 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.9331 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 1 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.001361 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.2455 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.01035 Highly Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 0.4293 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.09787 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.117 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.7097 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.1369 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 1 Highly Informative Inherited
Molecular Function (MF) binding 1.659e-10 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 6.291e-05 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.9382 Moderately Informative Inherited
Molecular Function (MF) kinase activity 2.587e-06 Informative Direct
Molecular Function (MF) enzyme binding 0.0007974 Informative Direct
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) DNA binding 0.3199 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 9.385e-06 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.0005734 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.7751 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0001077 Least Informative Direct
Cellular Component (CC) protein complex 6.976e-09 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1.676e-05 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 2.972e-15 Moderately Informative Direct
Cellular Component (CC) nuclear part 4.955e-08 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0007242 Moderately Informative Direct
Cellular Component (CC) nucleoplasm part 5.839e-15 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 2.496e-05 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.01301 Informative Inherited
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 0.01521 Informative Inherited
Cellular Component (CC) transcription factor complex 8.753e-13 Highly Informative Direct
Cellular Component (CC) microtubule organizing center part 7.157e-07 Highly Informative Direct
Cellular Component (CC) centrosome 9.208e-07 Highly Informative Direct
Cellular Component (CC) transcription elongation factor complex 6.796e-06 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0.0001568 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06703Least InformativeInherited
Disease Ontology (DO)nervous system disease0.1274Least InformativeInherited
Disease Ontology (DO)sensory system disease0.001544Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.001603Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.005039Moderately InformativeInherited
Disease Ontology (DO)laryngeal carcinoma4.308e-06InformativeDirect
Disease Ontology (DO)retinal disease5.464e-05InformativeDirect
Disease Ontology (DO)ocular cancer1InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.09657Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1197Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1389Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.223Least InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.002392Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.03371Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.03854Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.05573Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.08282Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.1958Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.3793Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4075Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.6468Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.7394Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.7903Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)ectopic neuron0.0008368InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.001432InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.008454InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.008907InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.02246InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.04757InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.05089InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.07465InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.2026InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.3118InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.491InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development6.27e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hematopoietic stem cell morphology0.0003367Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vitelline vasculature morphology0.0005204Highly InformativeDirect
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number0.0005519Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal apoptosis0.0005944Highly InformativeDirect
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.001459Highly InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0.00225Highly InformativeInherited
Mammalian Phenotype (MP)abnormal retinal ganglion cell morphology0.007453Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0006357Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.4248Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0001521Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0006089Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.0318Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.05913Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.2964Moderately InformativeInherited
Worm Phenotype (WP)pigmentation variant0.0004092InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0004092InformativeDirect
Worm Phenotype (WP)chromosome segregation variant0.0009942InformativeDirect
Worm Phenotype (WP)protein expression variant0.001456InformativeInherited
Worm Phenotype (WP)cell division variant0.01035InformativeInherited
Worm Phenotype (WP)nuclear number variant3.309e-07Highly InformativeDirect
Worm Phenotype (WP)embryonic cell morphology variant7.446e-07Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0001548Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.1624Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.08813Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.0008224InformativeDirect
Yeast Phenotype (YP)nuclear morphology6.795e-06Highly InformativeDirect
Yeast Phenotype (YP)budding0.02668Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective3.685e-05InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.0001537Least InformativeDirect
Xenopus ANatomical entity (XAN)zygote0.0008944Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processTranscription regulation6.64e-15Moderately InformativeDirect
Biological processMitosis1.247e-14InformativeDirect
Biological processMeiosis5.666e-07InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.0001032Moderately InformativeDirect
DiseaseTumor suppressor8.698e-07Moderately InformativeDirect
DomainRepeat2.677e-12Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionZinc1.28e-07Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationChromatin regulator0.0003397InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationMyristate0.0003207InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011028 SSF47954 Protein matches
Abstract

This domain is also found as the core domain in transcription factor IIB (TFIIB) and in the retinoblastoma tumour suppressor.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cyclin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the Cyclin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]