SUPERFAMILY 1.75 HMM library and genome assignments server


ERP29 C domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   ERP29 C domain-like [ 47932] (2)
Superfamily:   ERP29 C domain-like [ 47933]
Families:   ERP29 C domain-like [ 47934] (2)


Superfamily statistics
Genomes (368) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 490 0 6
Proteins 490 0 6


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 2.643e-08 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.03636 Least Informative Inherited
Biological Process (BP) protein folding 3.722e-15 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0008832 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0001652 Least Informative Direct
Cellular Component (CC) endoplasmic reticulum 1.127e-10 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
DomainSignal3.093e-16Least InformativeDirect
DomainRedox-active center2.347e-13InformativeDirect
Post-translational modificationIsomerase1.387e-10Moderately InformativeDirect
Post-translational modificationDisulfide bond2.094e-07Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011679 SSF47933 Protein matches
Abstract

ERp29 is a ubiquitously expressed endoplasmic reticulum protein found in mammals [PubMed11435111]. This protein is found associated with an N-terminal thioredoxin-like domain , which is homologous to the domain of human protein disulphide isomerase (PDI). ERp29 may help mediate the chaperone function of PDI. The C-terminal Erp29 domain has a 5-helical bundle fold. ERp29 is thought to form part of the thyroglobulin folding complex [PubMed11884402].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ERP29 C domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the ERP29 C domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]