SUPERFAMILY 1.75 HMM library and genome assignments server


Wiscott-Aldrich syndrome protein, WASP, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [ 47911]
Superfamily:   Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [ 47912]
Families:   Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [ 47913]


Superfamily statistics
Genomes (173) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 445 0 1
Proteins 308 0 1


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 8.402e-10 Least Informative Direct
Biological Process (BP) localization 4.333e-09 Least Informative Direct
Biological Process (BP) single-organism cellular process 6.177e-07 Least Informative Direct
Biological Process (BP) regulation of cellular process 1.29e-05 Least Informative Direct
Biological Process (BP) response to stimulus 0.005518 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 5.102e-10 Moderately Informative Direct
Biological Process (BP) organelle organization 1.87e-08 Moderately Informative Direct
Biological Process (BP) cellular localization 4.036e-08 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 6.383e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0004788 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0005218 Moderately Informative Direct
Biological Process (BP) immune system process 0.0007565 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0007979 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0181 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.007404 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 2.434e-14 Informative Direct
Biological Process (BP) regulation of organelle organization 2.627e-10 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 3.679e-08 Informative Direct
Biological Process (BP) regulation of anatomical structure size 3.787e-08 Informative Direct
Biological Process (BP) cell projection organization 6.119e-07 Informative Direct
Biological Process (BP) cytoskeleton organization 3.585e-06 Informative Direct
Biological Process (BP) response to other organism 1.72e-05 Informative Direct
Biological Process (BP) cellular component movement 4.452e-05 Informative Direct
Biological Process (BP) cellular membrane organization 5.025e-05 Informative Direct
Biological Process (BP) organelle localization 0.001688 Informative Inherited
Biological Process (BP) cell cycle process 0.003829 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01178 Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1.851e-08 Highly Informative Direct
Biological Process (BP) actin filament organization 2.114e-07 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 2.409e-07 Highly Informative Direct
Biological Process (BP) actin filament-based movement 5.282e-07 Highly Informative Direct
Biological Process (BP) vesicle organization 1.442e-05 Highly Informative Direct
Biological Process (BP) cell projection assembly 4.278e-05 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.01226 Highly Informative Inherited
Molecular Function (MF) binding 2.582e-05 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0005522 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1471 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0559 Least Informative Inherited
Cellular Component (CC) cytoskeleton 1.171e-09 Moderately Informative Direct
Cellular Component (CC) cell projection 1.959e-05 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0008839 Moderately Informative Direct
Cellular Component (CC) cell leading edge 1.87e-07 Informative Direct
Cellular Component (CC) cell cortex 9.445e-07 Informative Direct
Cellular Component (CC) actin cytoskeleton 8.77e-05 Informative Direct
Cellular Component (CC) cortical cytoskeleton 7.633e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
DomainRepeat7.189e-08Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011026 SSF47912 Protein matches
Abstract

The Rho-family GTPase, Cdc42, can regulate the actin cytoskeleton through activation of Wiskott-Aldrich syndrome protein (WASP) family members [PubMed10724160]. Mutations in WASP lead to the Wiskott-Aldrich syndrome, a paediatric disorder characterised by actin cytoskeletal defects in haematopoietic cells, leading clinically to thrombocytopenia, eczema and immunodeficiency. The WASP proteins signal to the cytoskeleton through the Arp2/3 complex, an actin-nucleating assembly that regulates the structure and dynamics of actin filament networks at the leading edge of the cell.

WASP family members have unique N-terminal regions, followed by a central segment rich in proline, and a common C-terminal region. The C-terminal region contains the VCA region that binds the Arp2/3 complex and actin, while the distinct N-terminal region enables family members to activate Arp2/3 in response to different upstream signals.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Wiscott-Aldrich syndrome protein, WASP, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Wiscott-Aldrich syndrome protein, WASP, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]