SUPERFAMILY 1.75 HMM library and genome assignments server


Transducin (alpha subunit), insertion domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transducin (alpha subunit), insertion domain [ 47894]
Superfamily:   Transducin (alpha subunit), insertion domain [ 47895]
Families:   Transducin (alpha subunit), insertion domain [ 47896]


Superfamily statistics
Genomes (391) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 3,468 3,159 25
Proteins 3,438 3,135 25


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.931e-15 Least Informative Direct
Biological Process (BP) multicellular organismal process 4.557e-11 Least Informative Direct
Biological Process (BP) developmental process 0.0002217 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.005316 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.8781 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.7945 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.9193 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9885 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.7693 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 3.057e-09 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 6.312e-08 Moderately Informative Direct
Biological Process (BP) system process 7.578e-07 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.09701 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.3878 Moderately Informative Inherited
Biological Process (BP) reproduction 0.08695 Moderately Informative Inherited
Biological Process (BP) organ development 0.482 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01094 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.8984 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.4216 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5974 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.03251 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1057 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.6629 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1255 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2999 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.468 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.01804 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.2207 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.4777 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2102 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3125 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.0483 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.03353 Moderately Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 1.773e-14 Informative Direct
Biological Process (BP) response to light stimulus 4.881e-10 Informative Direct
Biological Process (BP) regulation of body fluid levels 5.543e-07 Informative Direct
Biological Process (BP) response to wounding 7.33e-07 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 7.067e-06 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 6.527e-05 Informative Direct
Biological Process (BP) cation homeostasis 0.0001438 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.0001453 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0002325 Informative Direct
Biological Process (BP) cell activation 0.0004157 Informative Direct
Biological Process (BP) response to nutrient levels 0.0005577 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.002914 Informative Inherited
Biological Process (BP) reproductive structure development 0.4167 Informative Inherited
Biological Process (BP) generation of neurons 0.01688 Informative Inherited
Biological Process (BP) organ morphogenesis 0.3129 Informative Inherited
Biological Process (BP) sensory organ development 0.175 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.0711 Informative Inherited
Biological Process (BP) glycosyl compound catabolic process 0.001358 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.002971 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.01604 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.001136 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.009567 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.4331 Informative Inherited
Biological Process (BP) regulation of nucleotide catabolic process 0.9307 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.003972 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.00461 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.00238 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.01715 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.004358 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) hemostasis 4.755e-14 Highly Informative Direct
Biological Process (BP) cell division 1.255e-11 Highly Informative Direct
Biological Process (BP) detection of light stimulus 5.183e-10 Highly Informative Direct
Biological Process (BP) coagulation 2.158e-09 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 2.525e-09 Highly Informative Direct
Biological Process (BP) regulation of phospholipase activity 8.297e-08 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 9.359e-07 Highly Informative Direct
Biological Process (BP) sensory perception 3.506e-06 Highly Informative Direct
Biological Process (BP) fruiting body development 5.325e-06 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 8.887e-05 Highly Informative Direct
Biological Process (BP) wound healing 0.0001002 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.0001836 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.0001948 Highly Informative Direct
Biological Process (BP) response to alkaloid 0.0002615 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0.0007278 Highly Informative Direct
Biological Process (BP) response to carbohydrate stimulus 0.0008317 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.0009772 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.001963 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.4701 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.003246 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 0.2179 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 6.49e-05 Least Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 7.86e-10 Informative Direct
Molecular Function (MF) molecular transducer activity 4.422e-09 Informative Direct
Molecular Function (MF) receptor binding 0.0001176 Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.01013 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 6.981e-08 Moderately Informative Direct
Cellular Component (CC) cell projection 1.32e-06 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 2.73e-12 Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 0 Highly Informative Direct
Cellular Component (CC) midbody 0 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) centrosome 0 Highly Informative Direct
Cellular Component (CC) cilium 1.482e-09 Highly Informative Direct
Cellular Component (CC) cell body 5.657e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.07565Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.07742Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.178Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2345Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.03905Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.06043Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1473Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.1729Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.1881Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic system physiology0.3349Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.3512Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.006025InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.01076InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.01218InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.01422InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.02129InformativeInherited
Mammalian Phenotype (MP)abnormal mineral homeostasis0.03068InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.0319InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.05234InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.05991InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.09804InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1353InformativeInherited
Mammalian Phenotype (MP)decreased systemic arterial blood pressure3.148e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology4.647e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation8.229e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.0005211Highly InformativeDirect
Mammalian Phenotype (MP)fused joints0.001036Highly InformativeInherited
Mammalian Phenotype (MP)abnormal eye electrophysiology0.003861Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vascular smooth muscle physiology0.003957Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating mineral level0.01743Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.0567Highly InformativeInherited
Mammalian Phenotype (MP)abnormal rib attachment0.06818Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.4677Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.03179Least InformativeInherited
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.1327Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.168Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant2.17e-05InformativeDirect
Worm Phenotype (WP)activity level variant0.01864InformativeInherited
Worm Phenotype (WP)carbon dioxide avoidance variant0Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant1.117e-09Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant9.244e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant ANatomical entity (PAN)rosette leaf2.102e-06InformativeDirect
Plant ANatomical entity (PAN)vascular system9.191e-06InformativeDirect
Plant ANatomical entity (PAN)fruit1.315e-05InformativeDirect
Plant ANatomical entity (PAN)shoot axis stele4.885e-10Highly InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle2.851e-09Moderately InformativeDirect
Biological processSensory transduction5.623e-13InformativeDirect
Biological processVision0.0001513Highly InformativeDirect
Cellular componentMembrane1.158e-06Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton1.732e-13Moderately InformativeDirect
Cellular componentCell membrane2.417e-05Moderately InformativeDirect
DiseaseDisease mutation0.000168Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationADP-ribosylation0InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011025 SSF47895 Protein matches
Abstract

Guanine nucleotide binding proteins (G proteins) are membrane-associated, heterotrimeric proteins composed of three subunits: alpha , beta and gamma [PubMed15119945]. G proteins act as signal transducers, relaying a signal from a ligand-activated GPCR (G protein-coupled receptor) to an enzyme or ion channel effector. The activated GPCR promotes the exchange of GDP for GTP on the G protein alpha subunit, allowing the trimeric G protein to be released from the receptor and to dissociate into active (GTP-bound) alpha subunit and beta/gamma dimer, both of which activate distinct downstream effectors. There are several isoforms of each subunit, which together can makeup hundreds of combinations of G proteins, each one linking a specific receptor to a certain effector.

The heterotrimeric G protein alpha subunit is composed of two domains: a GTP-binding domain and a helical insertion domain. The GTP-binding domain is homologous to Ras-like small GTPases, and includes switch regions I and II, which change conformation during activation. The helical insertion domain is inserted into the GTP-binding domain before switch region I, and is unique to heterotrimeric G proteins. This helical insertion domain functions to sequester the guanine nucleotide at the interface with the GTP-binding domain and must be displaced to enable nucleotide dissociation [PubMed12517447]. This entry represents the G protein alpha subunit helical insertion domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transducin (alpha subunit), insertion domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Transducin (alpha subunit), insertion domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]