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  Home > SCOP hierarchy > Transducin (alpha subunit), insertion domain superfamily


Transducin (alpha subunit), insertion domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transducin (alpha subunit), insertion domain [ 47894]
Superfamily:   Transducin (alpha subunit), insertion domain [ 47895]
Families:   Transducin (alpha subunit), insertion domain [ 47896]

 Superfamily statistics
Genomes (390) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 3,439 3,159 25
Proteins 3,409 3,135 25

 Functional annotation
General category Regulation
Detailed category Signal transduction

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.484e-07 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0004824 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.1372 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7582 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.6017 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.815 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.6644 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) system process 2.611e-10 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 4.052e-05 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0007478 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.8159 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4439 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.7405 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.052 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.6081 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.09887 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.3439 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2045 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1005 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.00124 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.07234 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.8573 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4173 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4869 Moderately Informative Inherited
Biological Process (BP) response to light stimulus 1.196e-08 Informative Direct
Biological Process (BP) purine nucleotide metabolic process 3.508e-08 Informative Direct
Biological Process (BP) ribose phosphate metabolic process 4.226e-08 Informative Direct
Biological Process (BP) organophosphate catabolic process 1.253e-07 Informative Direct
Biological Process (BP) ribonucleoside metabolic process 4.381e-07 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 5.799e-07 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 1.407e-05 Informative Direct
Biological Process (BP) response to wounding 3.277e-05 Informative Direct
Biological Process (BP) regulation of body fluid levels 6.349e-05 Informative Direct
Biological Process (BP) positive regulation of phosphorus metabolic process 9.661e-05 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0001047 Informative Direct
Biological Process (BP) response to organic nitrogen 0.0004182 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.0006266 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.07578 Informative Inherited
Biological Process (BP) generation of neurons 0.06061 Informative Inherited
Biological Process (BP) organ morphogenesis 0.2367 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.06248 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.3779 Informative Inherited
Biological Process (BP) sensory organ development 0.1265 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.08085 Informative Inherited
Biological Process (BP) cellular cation homeostasis 1 Informative Inherited
Biological Process (BP) purine nucleoside metabolic process 0.0605 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.08989 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.006974 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.09607 Informative Inherited
Biological Process (BP) cell activation 0.04473 Informative Inherited
Biological Process (BP) regulation of ion transport 0.02196 Informative Inherited
Biological Process (BP) response to external stimulus 0.8063 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 1.468e-11 Highly Informative Direct
Biological Process (BP) hemostasis 3.115e-10 Highly Informative Direct
Biological Process (BP) sensory perception 1.448e-09 Highly Informative Direct
Biological Process (BP) cell division 2.178e-09 Highly Informative Direct
Biological Process (BP) nucleoside triphosphate catabolic process 5.912e-09 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 9.042e-09 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 1.57e-08 Highly Informative Direct
Biological Process (BP) regulation of phospholipase activity 2.005e-07 Highly Informative Direct
Biological Process (BP) coagulation 4.544e-07 Highly Informative Direct
Biological Process (BP) phototransduction 4.117e-06 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 2.947e-05 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 7.022e-05 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 8.94e-05 Highly Informative Direct
Biological Process (BP) response to alkaloid 0.0001186 Highly Informative Direct
Biological Process (BP) wound healing 0.0003617 Highly Informative Direct
Biological Process (BP) nucleotide catabolic process 0.0005893 Highly Informative Direct
Biological Process (BP) response to carbohydrate stimulus 0.0007346 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.001793 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.2343 Highly Informative Inherited
Biological Process (BP) detection of visible light 0.006384 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.003074 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1.723e-12 Least Informative Direct
Molecular Function (MF) anion binding 2.333e-15 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 0.1053 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.1278 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.01894 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) protein complex binding 0 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.1132 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 9.972e-07 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1.577e-06 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 6.002e-11 Informative Direct
Cellular Component (CC) neuron part 0.0342 Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 0 Highly Informative Direct
Cellular Component (CC) midbody 0 Highly Informative Direct
Cellular Component (CC) nonmotile primary cilium 0 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0 Highly Informative Direct
Cellular Component (CC) cell body 0.0001736 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.06282Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1018Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1144Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.01322Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.02048Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.13Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.1362Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.3568Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.005556InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.009697InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.01095InformativeInherited
Mammalian Phenotype (MP)abnormal mineral homeostasis0.01397InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.01947InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.02028InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.03131InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.08089InformativeInherited
Mammalian Phenotype (MP)abnormal circulating hormone level0.08739InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.09242InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1523InformativeInherited
Mammalian Phenotype (MP)decreased systemic arterial blood pressure1.75e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology2.635e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.0002166Highly InformativeDirect
Mammalian Phenotype (MP)vertebral fusion0.0002784Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.0006637Highly InformativeDirect
Mammalian Phenotype (MP)abnormal oxygen level0.0007385Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular smooth muscle physiology0.004973Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating mineral level0.005113Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.05266Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pectoral girdle bone morphology0.0959Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.03179Least InformativeInherited
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.1327Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.168Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant2.17e-05InformativeDirect
Worm Phenotype (WP)activity level variant0.01864InformativeInherited
Worm Phenotype (WP)carbon dioxide avoidance variant0Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant1.117e-09Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant9.244e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)pedicel0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)leaf lamina0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)stalk0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)phyllome apex0Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0Least InformativeDirect
Plant ANatomical entity (PAN)stele2.544e-07InformativeDirect
Plant ANatomical entity (PAN)rosette leaf1.995e-06InformativeDirect
Plant ANatomical entity (PAN)fruit1.236e-05InformativeDirect
Plant ANatomical entity (PAN)shoot axis stele4.653e-10Highly InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle1.694e-09Moderately InformativeDirect
Biological processSensory transduction4.182e-13InformativeDirect
Biological processVision0.0001423Highly InformativeDirect
Cellular componentMembrane2.407e-06Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton4.183e-14Moderately InformativeDirect
Cellular componentCell membrane4.603e-05Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect
Post-translational modificationADP-ribosylation3.05e-15InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011025 SSF47895 Protein matches
Abstract

Guanine nucleotide binding proteins (G proteins) are membrane-associated, heterotrimeric proteins composed of three subunits: alpha , beta and gamma [PubMed15119945]. G proteins act as signal transducers, relaying a signal from a ligand-activated GPCR (G protein-coupled receptor) to an enzyme or ion channel effector. The activated GPCR promotes the exchange of GDP for GTP on the G protein alpha subunit, allowing the trimeric G protein to be released from the receptor and to dissociate into active (GTP-bound) alpha subunit and beta/gamma dimer, both of which activate distinct downstream effectors. There are several isoforms of each subunit, which together can makeup hundreds of combinations of G proteins, each one linking a specific receptor to a certain effector.

The heterotrimeric G protein alpha subunit is composed of two domains: a GTP-binding domain and a helical insertion domain. The GTP-binding domain is homologous to Ras-like small GTPases, and includes switch regions I and II, which change conformation during activation. The helical insertion domain is inserted into the GTP-binding domain before switch region I, and is unique to heterotrimeric G proteins. This helical insertion domain functions to sequester the guanine nucleotide at the interface with the GTP-binding domain and must be displaced to enable nucleotide dissociation [PubMed12517447]. This entry represents the G protein alpha subunit helical insertion domain.


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transducin (alpha subunit), insertion domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Transducin (alpha subunit), insertion domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.