SUPERFAMILY 1.75 HMM library and genome assignments server

Annexin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Annexin [ 47873]
Superfamily:   Annexin [ 47874]
Families:   Annexin [ 47875] (9)


Superfamily statistics
Genomes (348) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,075 3,553 37
Proteins 2,911 3,372 35


Functional annotation
General category Processes_IC
Detailed category Phospholipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.000037080.00000704Least InformativeDirect
Biological Process (BP)positive regulation of biological process0.19821Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)developmental process0.00016050.4777Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.087680.5841Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.00046480.2215Least InformativeInherited
Biological Process (BP)response to stimulus0.0011830.04672Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0020920.2324Least InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00098860.4144Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.5090.7717Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.33070.3578Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.33340.1989Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.0096180.02512Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0065860.001487Moderately InformativeInherited
Biological Process (BP)ion transport0.1650.001337Moderately InformativeInherited
Biological Process (BP)organic substance transport0.26460.9998Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.02310.6357Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0074570.02585Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0052130.0003023Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.079610.44Moderately InformativeInherited
Biological Process (BP)response to acid chemical0.000017050.00006818InformativeDirect
Biological Process (BP)response to inorganic substance0.0000028450.0000004428InformativeDirect
Biological Process (BP)lipid localization0.00013540.00006673InformativeDirect
Biological Process (BP)metal ion transport0.00038730.0000000001206InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.00000012420.00009008InformativeDirect
Biological Process (BP)negative regulation of catalytic activity0.000022440.0005456InformativeDirect
Biological Process (BP)cardiovascular system development0.000019320.0009293InformativeDirect
Biological Process (BP)regulation of response to wounding0.0000000015840.0000003752InformativeDirect
Biological Process (BP)regulation of cell cycle process0.000045830.009218InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.000029220.004052InformativeInherited
Biological Process (BP)negative regulation of multicellular organismal process0.000046440.00852InformativeInherited
Biological Process (BP)ion transmembrane transport0.18750.468InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0013670.006923InformativeInherited
Biological Process (BP)anion transport0.52111InformativeInherited
Biological Process (BP)organic acid transport0.023840.04283InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00028980.01149InformativeInherited
Biological Process (BP)angiogenesis0.000000015020.00000004689Highly InformativeDirect
Biological Process (BP)calcium ion transport0.0000031180Highly InformativeDirect
Biological Process (BP)response to heat0.0000000050710.000001395Highly InformativeDirect
Biological Process (BP)response to cold0.00000000015820.0000002034Highly InformativeDirect
Biological Process (BP)response to water deprivation0.0000000000088470.000000001837Highly InformativeDirect
Biological Process (BP)response to salt stress0.0000000007040.000000000000001913Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport0.000000048940.0000005722Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus0.00000000003860.00000003136Highly InformativeDirect
Biological Process (BP)positive regulation of mitotic cell cycle0.000000022410.000005673Highly InformativeDirect
Biological Process (BP)negative regulation of coagulation0.00000000014240.000000000001846Highly InformativeDirect
Biological Process (BP)regulation of binding0.0000085350.00002556Highly InformativeDirect
Biological Process (BP)regulation of wound healing0.0000000000000016820.00000000001081Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process0.000099320.00005174Highly InformativeDirect
Biological Process (BP)negative regulation of hemostasis0.000000000071540.0000000000007652Highly InformativeDirect
Biological Process (BP)negative regulation of response to wounding0.0000000000019270.0000000002216Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle0.000000017730.0000006283Highly InformativeDirect
Biological Process (BP)extracellular matrix organization10.000000807Highly InformativeInherited
Molecular Function (MF)binding0.00000000031950.00000002345Least InformativeDirect
Molecular Function (MF)anion binding0.0000056590.000005649Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.15560.025Moderately InformativeInherited
Molecular Function (MF)cation binding11Moderately InformativeInherited
Molecular Function (MF)transporter activity0.20480.04413Moderately InformativeInherited
Molecular Function (MF)enzyme regulator activity0.0010650.01016Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.0016570.00007934Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity0.00004680.00003417InformativeDirect
Molecular Function (MF)lipid binding0.0000000000079280InformativeDirect
Molecular Function (MF)metal ion transmembrane transporter activity0.00017550.0001395InformativeDirect
Molecular Function (MF)sulfur compound binding0.00026180.000003217InformativeDirect
Molecular Function (MF)carboxylic acid binding0.12960.06679InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.068980.07842InformativeInherited
Molecular Function (MF)calcium ion binding0.000010930.000000003703Highly InformativeDirect
Molecular Function (MF)calcium ion transmembrane transporter activity0.00000030090.0000005923Highly InformativeDirect
Molecular Function (MF)amino acid binding0.000000021050.0000000008368Highly InformativeDirect
Molecular Function (MF)cation channel activity0.0000029950.003482Highly InformativeInherited
Cellular Component (CC)membrane0.000000000031710.00000001038Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.4510.679Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.44850.005923Least InformativeInherited
Cellular Component (CC)vesicle0.000028320.0000000000002738Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.000059230.000588Moderately InformativeDirect
Cellular Component (CC)plasma membrane part0.00025410.06781Moderately InformativeInherited
Cellular Component (CC)endosome0.000000012430.0000001625InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle0.00025410.00001139InformativeDirect
Cellular Component (CC)sarcolemma00.00000000000396Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.00000704 Least Informative Direct
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.4777 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.5841 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2215 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.04672 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.2324 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.0003023 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.4144 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.7717 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1387 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3578 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1989 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.02512 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001487 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.5839 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1201 Moderately Informative Inherited
Biological Process (BP) ion transport 0.001337 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9998 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.6357 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.02585 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.44 Moderately Informative Inherited
Biological Process (BP) response to acid chemical 0.00006818 Informative Direct
Biological Process (BP) response to inorganic substance 0.0000004428 Informative Direct
Biological Process (BP) lipid localization 0.00006673 Informative Direct
Biological Process (BP) metal ion transport 0.0000000001206 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00009008 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0005456 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00001813 Informative Direct
Biological Process (BP) cation homeostasis 0.00000006177 Informative Direct
Biological Process (BP) cardiovascular system development 0.0009293 Informative Direct
Biological Process (BP) regulation of response to wounding 0.0000003752 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.009218 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.004052 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.00852 Informative Inherited
Biological Process (BP) regulation of system process 0.001022 Informative Inherited
Biological Process (BP) ion transmembrane transport 0.468 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.006923 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 0.04283 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.08532 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.001949 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01149 Informative Inherited
Biological Process (BP) angiogenesis 0.00000004689 Highly Informative Direct
Biological Process (BP) calcium ion transport 0 Highly Informative Direct
Biological Process (BP) response to heat 0.000001395 Highly Informative Direct
Biological Process (BP) response to cold 0.0000002034 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.000000001837 Highly Informative Direct
Biological Process (BP) response to salt stress 0.000000000000001913 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.0000005722 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.000000807 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.00000003136 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.000005673 Highly Informative Direct
Biological Process (BP) negative regulation of coagulation 0.000000000001846 Highly Informative Direct
Biological Process (BP) regulation of binding 0.00002556 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.00000000001081 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.00005174 Highly Informative Direct
Biological Process (BP) regulation of muscle system process 0.0000000005232 Highly Informative Direct
Biological Process (BP) negative regulation of hemostasis 0.0000000000007652 Highly Informative Direct
Biological Process (BP) negative regulation of response to wounding 0.0000000002216 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.0000006283 Highly Informative Direct
Molecular Function (MF) binding 0.00000002345 Least Informative Direct
Molecular Function (MF) anion binding 0.000005649 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00007934 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.025 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.04413 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.01016 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.00003417 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0001395 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000003217 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.06679 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.07842 Informative Inherited
Molecular Function (MF) calcium ion binding 0.000000003703 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.0000005923 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.0000000008368 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.003482 Highly Informative Inherited
Cellular Component (CC) membrane 0.00000001038 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.005923 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.8414 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.679 Least Informative Inherited
Cellular Component (CC) vesicle 0.0000000000002738 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.000588 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.06781 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.001545 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.3766 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.0002681 Informative Direct
Cellular Component (CC) endosome 0.0000001625 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.00001139 Informative Direct
Cellular Component (CC) sarcolemma 0.00000000000396 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0000009412 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0.0146Moderately InformativeInherited

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.00007938Moderately InformativeDirect
Worm Phenotype (WP)brood size variant0.0002426InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHemostasis0InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Cellular componentNucleus0.000143Least InformativeDirect
Cellular componentCytoplasm0.5139Least InformativeInherited
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoskeleton0.0000000007372Moderately InformativeDirect
Cellular componentSecreted0.0007966Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentMicrotubule0.0000000004781InformativeDirect
Cellular componentBasement membrane0Highly InformativeDirect
Cellular componentCilium0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0.0005791Least InformativeDirect
Post-translational modificationIsopeptide bond0.00000001037Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001464 SSF47874 Protein matches
Abstract


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Annexin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the Annexin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]