Annexin superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	All alpha proteins [ 46456] (284)
Fold:	Annexin [ 47873]
Superfamily:	Annexin [ 47874]
Families:	Annexin [ 47875] (9)

Superfamily statistics

	Genomes (298)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	2,669	2,617	37
Proteins	2,531	2,472	35

Functional annotation

General category	Processes_IC
Detailed category	Phospholipid metabolism and transport

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)

	GO term	FDR (singleton)	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	response to stimulus	9.766e-07	3.326e-05	Least Informative	Direct
Biological Process (BP)	regulation of cellular process	1	1	Least Informative	Inherited
Biological Process (BP)	localization	0.008368	0.0005447	Least Informative	Inherited
Biological Process (BP)	single-organism cellular process	0.0004117	0.05171	Least Informative	Inherited
Biological Process (BP)	cellular component organization or biogenesis	0.005006	0.3499	Least Informative	Inherited
Biological Process (BP)	multicellular organismal process	0.00338	0.2216	Least Informative	Inherited
Biological Process (BP)	developmental process	0.001618	0.7455	Least Informative	Inherited
Biological Process (BP)	positive regulation of cellular process	0.0005941	0.3379	Moderately Informative	Inherited
Biological Process (BP)	regulation of response to stimulus	0.07765	0.6245	Moderately Informative	Inherited
Biological Process (BP)	cellular response to chemical stimulus	0.4883	0.6994	Moderately Informative	Inherited
Biological Process (BP)	regulation of molecular function	0.02316	0.175	Moderately Informative	Inherited
Biological Process (BP)	regulation of multicellular organismal process	0.008297	0.0007884	Moderately Informative	Inherited
Biological Process (BP)	ion transport	0.1409	0.005349	Moderately Informative	Inherited
Biological Process (BP)	organic substance transport	0.03492	0.6901	Moderately Informative	Inherited
Biological Process (BP)	response to oxygen-containing compound	0.2532	0.3867	Moderately Informative	Inherited
Biological Process (BP)	response to abiotic stimulus	0.03859	0.004244	Moderately Informative	Inherited
Biological Process (BP)	macromolecule localization	0.001333	0.3042	Moderately Informative	Inherited
Biological Process (BP)	anatomical structure morphogenesis	0.001283	0.1803	Moderately Informative	Inherited
Biological Process (BP)	single-organism developmental process	0.02939	1	Moderately Informative	Inherited
Biological Process (BP)	lipid transport	1.967e-06	0.0001387	Informative	Direct
Biological Process (BP)	regulation of response to external stimulus	2.081e-09	3.819e-07	Informative	Direct
Biological Process (BP)	secretion	1.888e-07	0.0006664	Informative	Direct
Biological Process (BP)	cardiovascular system development	6.033e-06	0.0005317	Informative	Direct
Biological Process (BP)	regulation of response to stress	2.026e-07	0.0002542	Informative	Direct
Biological Process (BP)	regulation of cell cycle process	6.814e-05	0.006588	Informative	Inherited
Biological Process (BP)	regulation of mitotic cell cycle	2.753e-05	0.00165	Informative	Inherited
Biological Process (BP)	anion transport	0.09973	0.8602	Informative	Inherited
Biological Process (BP)	organic acid transport	0.003541	0.01496	Informative	Inherited
Biological Process (BP)	response to inorganic substance	0.002979	1.114e-05	Informative	Inherited
Biological Process (BP)	anatomical structure formation involved in morphogenesis	4.316e-05	0.007538	Informative	Inherited
Biological Process (BP)	response to acid	2.946e-07	9.433e-08	Highly Informative	Direct
Biological Process (BP)	angiogenesis	7.882e-09	2.892e-08	Highly Informative	Direct
Biological Process (BP)	response to osmotic stress	5.603e-08	4.176e-13	Highly Informative	Direct
Biological Process (BP)	response to heat	1.778e-09	1.23e-06	Highly Informative	Direct
Biological Process (BP)	response to cold	3.071e-10	4.264e-07	Highly Informative	Direct
Biological Process (BP)	response to water deprivation	1.754e-11	3.086e-09	Highly Informative	Direct
Biological Process (BP)	monocarboxylic acid transport	2.78e-08	2.592e-07	Highly Informative	Direct
Biological Process (BP)	regulation of blood coagulation	3.275e-09	4.767e-08	Highly Informative	Direct
Biological Process (BP)	extracellular matrix organization	8.371e-12	1.893e-07	Highly Informative	Direct
Biological Process (BP)	regulation of binding	3.136e-08	4.397e-08	Highly Informative	Direct
Biological Process (BP)	negative regulation of multicellular organismal process	8.197e-08	1.399e-05	Highly Informative	Direct
Biological Process (BP)	positive regulation of cell cycle process	4.298e-05	1.568e-05	Highly Informative	Direct
Biological Process (BP)	regulation of G1/S transition of mitotic cell cycle	2.556e-08	3.02e-07	Highly Informative	Direct
Molecular Function (MF)	binding	7.928e-08	1.159e-07	Least Informative	Direct
Molecular Function (MF)	anion binding	7.581e-05	8.217e-05	Moderately Informative	Direct
Molecular Function (MF)	cation binding	1	1	Moderately Informative	Inherited
Molecular Function (MF)	enzyme regulator activity	0.003924	0.02228	Moderately Informative	Inherited
Molecular Function (MF)	enzyme inhibitor activity	0.0001716	4.508e-05	Informative	Direct
Molecular Function (MF)	lipid binding	2.057e-11	0	Informative	Direct
Molecular Function (MF)	carboxylic acid binding	0.1642	0.0651	Informative	Inherited
Molecular Function (MF)	calcium ion binding	0.000214	3.26e-08	Highly Informative	Direct
Molecular Function (MF)	modified amino acid binding	1.055e-07	1.812e-10	Highly Informative	Direct
Cellular Component (CC)	membrane	7.836e-06	6.634e-05	Least Informative	Direct
Cellular Component (CC)	intracellular membrane-bounded organelle	0.4616	1	Least Informative	Inherited
Cellular Component (CC)	cytoplasmic part	0.7523	0.0137	Least Informative	Inherited
Cellular Component (CC)	plasma membrane	1.219e-07	1.164e-07	Moderately Informative	Direct
Cellular Component (CC)	endosome	2.459e-08	3.137e-06	Informative	Direct
Cellular Component (CC)	extrinsic to plasma membrane	6.041e-08	6.394e-09	Highly Informative	Direct
Cellular Component (CC)	sarcolemma	0	2.67e-13	Highly Informative	Direct

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	response to stimulus	3.326e-05	Least Informative	Direct
Biological Process (BP)	localization	0.0005447	Least Informative	Direct
Biological Process (BP)	regulation of cellular process	1	Least Informative	Inherited
Biological Process (BP)	single-organism cellular process	0.05171	Least Informative	Inherited
Biological Process (BP)	cellular component organization or biogenesis	0.3499	Least Informative	Inherited
Biological Process (BP)	multicellular organismal process	0.2216	Least Informative	Inherited
Biological Process (BP)	developmental process	0.7455	Least Informative	Inherited
Biological Process (BP)	regulation of multicellular organismal process	0.0007884	Moderately Informative	Direct
Biological Process (BP)	positive regulation of cellular process	0.3379	Moderately Informative	Inherited
Biological Process (BP)	regulation of response to stimulus	0.6245	Moderately Informative	Inherited
Biological Process (BP)	cellular response to chemical stimulus	0.6994	Moderately Informative	Inherited
Biological Process (BP)	regulation of molecular function	0.175	Moderately Informative	Inherited
Biological Process (BP)	ion transport	0.005349	Moderately Informative	Inherited
Biological Process (BP)	regulation of cellular component organization	0.03474	Moderately Informative	Inherited
Biological Process (BP)	regulation of developmental process	0.3096	Moderately Informative	Inherited
Biological Process (BP)	organic substance transport	0.6901	Moderately Informative	Inherited
Biological Process (BP)	macromolecule localization	0.3042	Moderately Informative	Inherited
Biological Process (BP)	homeostatic process	0.1507	Moderately Informative	Inherited
Biological Process (BP)	response to oxygen-containing compound	0.3867	Moderately Informative	Inherited
Biological Process (BP)	response to abiotic stimulus	0.004244	Moderately Informative	Inherited
Biological Process (BP)	anatomical structure morphogenesis	0.1803	Moderately Informative	Inherited
Biological Process (BP)	single-organism developmental process	1	Moderately Informative	Inherited
Biological Process (BP)	lipid transport	0.0001387	Informative	Direct
Biological Process (BP)	response to inorganic substance	1.114e-05	Informative	Direct
Biological Process (BP)	regulation of anatomical structure morphogenesis	0.0005669	Informative	Direct
Biological Process (BP)	metal ion transport	2.06e-06	Informative	Direct
Biological Process (BP)	cellular cation homeostasis	3.073e-06	Informative	Direct
Biological Process (BP)	regulation of response to external stimulus	3.819e-07	Informative	Direct
Biological Process (BP)	secretion	0.0006664	Informative	Direct
Biological Process (BP)	regulation of body fluid levels	9.004e-06	Informative	Direct
Biological Process (BP)	cardiovascular system development	0.0005317	Informative	Direct
Biological Process (BP)	regulation of response to stress	0.0002542	Informative	Direct
Biological Process (BP)	regulation of cell cycle process	0.006588	Informative	Inherited
Biological Process (BP)	regulation of mitotic cell cycle	0.00165	Informative	Inherited
Biological Process (BP)	anion transport	0.8602	Informative	Inherited
Biological Process (BP)	organic acid transport	0.01496	Informative	Inherited
Biological Process (BP)	regulation of system process	0.0104	Informative	Inherited
Biological Process (BP)	metal ion homeostasis	0.1104	Informative	Inherited
Biological Process (BP)	anatomical structure formation involved in morphogenesis	0.007538	Informative	Inherited
Biological Process (BP)	response to acid	9.433e-08	Highly Informative	Direct
Biological Process (BP)	angiogenesis	2.892e-08	Highly Informative	Direct
Biological Process (BP)	calcium ion transport	1.217e-09	Highly Informative	Direct
Biological Process (BP)	cellular calcium ion homeostasis	3.442e-07	Highly Informative	Direct
Biological Process (BP)	regulation of muscle contraction	3.53e-11	Highly Informative	Direct
Biological Process (BP)	response to osmotic stress	4.176e-13	Highly Informative	Direct
Biological Process (BP)	response to heat	1.23e-06	Highly Informative	Direct
Biological Process (BP)	response to cold	4.264e-07	Highly Informative	Direct
Biological Process (BP)	response to water deprivation	3.086e-09	Highly Informative	Direct
Biological Process (BP)	monocarboxylic acid transport	2.592e-07	Highly Informative	Direct
Biological Process (BP)	regulation of cell morphogenesis	0.000176	Highly Informative	Direct
Biological Process (BP)	regulation of blood coagulation	4.767e-08	Highly Informative	Direct
Biological Process (BP)	extracellular matrix organization	1.893e-07	Highly Informative	Direct
Biological Process (BP)	regulation of binding	4.397e-08	Highly Informative	Direct
Biological Process (BP)	negative regulation of multicellular organismal process	1.399e-05	Highly Informative	Direct
Biological Process (BP)	positive regulation of cell cycle process	1.568e-05	Highly Informative	Direct
Biological Process (BP)	regulation of G1/S transition of mitotic cell cycle	3.02e-07	Highly Informative	Direct
Molecular Function (MF)	binding	1.159e-07	Least Informative	Direct
Molecular Function (MF)	anion binding	8.217e-05	Moderately Informative	Direct
Molecular Function (MF)	cation binding	1	Moderately Informative	Inherited
Molecular Function (MF)	enzyme regulator activity	0.02228	Moderately Informative	Inherited
Molecular Function (MF)	enzyme inhibitor activity	4.508e-05	Informative	Direct
Molecular Function (MF)	lipid binding	0	Informative	Direct
Molecular Function (MF)	carboxylic acid binding	0.0651	Informative	Inherited
Molecular Function (MF)	calcium ion binding	3.26e-08	Highly Informative	Direct
Molecular Function (MF)	modified amino acid binding	1.812e-10	Highly Informative	Direct
Cellular Component (CC)	membrane	6.634e-05	Least Informative	Direct
Cellular Component (CC)	cytoplasmic part	0.0137	Least Informative	Inherited
Cellular Component (CC)	intracellular organelle part	1	Least Informative	Inherited
Cellular Component (CC)	intracellular membrane-bounded organelle	1	Least Informative	Inherited
Cellular Component (CC)	plasma membrane	1.164e-07	Moderately Informative	Direct
Cellular Component (CC)	endomembrane system	0.0002759	Moderately Informative	Direct
Cellular Component (CC)	organelle envelope	0.0009564	Moderately Informative	Direct
Cellular Component (CC)	vesicle	1.357e-08	Moderately Informative	Direct
Cellular Component (CC)	nuclear part	0.577	Moderately Informative	Inherited
Cellular Component (CC)	nuclear envelope	1.383e-06	Informative	Direct
Cellular Component (CC)	endosome	3.137e-06	Informative	Direct
Cellular Component (CC)	extrinsic to plasma membrane	6.394e-09	Highly Informative	Direct
Cellular Component (CC)	midbody	2.034e-06	Highly Informative	Direct
Cellular Component (CC)	sarcolemma	2.67e-13	Highly Informative	Direct
Cellular Component (CC)	perinuclear region of cytoplasm	5.86e-07	Highly Informative	Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)

	DO term	FDR (all)	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	bone disease	0.008635	Moderately Informative	Inherited

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)

	WP term	FDR (all)	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	Least Informative	Direct
Worm Phenotype (WP)	developmental timing variant	0	Least Informative	Direct
Worm Phenotype (WP)	larval development variant	0	Least Informative	Direct
Worm Phenotype (WP)	larval lethal	0	Moderately Informative	Direct
Worm Phenotype (WP)	sterile progeny	0	Moderately Informative	Direct
Worm Phenotype (WP)	germ cell morphology variant	7.938e-05	Moderately Informative	Direct
Worm Phenotype (WP)	brood size variant	0.0002426	Informative	Direct

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Blood coagulation	0	Highly Informative	Direct
Cellular component	Nucleus	9.357e-05	Least Informative	Direct
Cellular component	Cytoplasm	0.4559	Least Informative	Inherited
Cellular component	Cell projection	0	Moderately Informative	Direct
Cellular component	Cytoskeleton	3.124e-10	Moderately Informative	Direct
Cellular component	Secreted	0.002104	Moderately Informative	Inherited
Cellular component	Extracellular matrix	0	Informative	Direct
Cellular component	Microtubule	4.374e-10	Informative	Direct
Cellular component	Basement membrane	0	Highly Informative	Direct
Cellular component	Cilium	0	Highly Informative	Direct
Domain	Repeat	0	Least Informative	Direct
Molecular function	Calcium	0	Moderately Informative	Direct
Post-translational modification	Phosphoprotein	6.946e-05	Least Informative	Direct
Post-translational modification	Acetylation	0	Moderately Informative	Direct
Post-translational modification	Isopeptide bond	7.252e-10	Moderately Informative	Direct

Document: KW annotation of SCOP domains

InterPro annotation

Cross references IPR001464 SSF47874 Protein matches

Abstract

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Annexin domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the Annexin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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Annexin superfamily