SUPERFAMILY 1.75 HMM library and genome assignments server


SAM/Pointed domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   SAM domain-like [ 47768] (16)
Superfamily:   SAM/Pointed domain [ 47769] (3)
Families:   Pointed domain [ 47770] (6)
  SAM (sterile alpha motif) domain [ 47773] (15)
  Variant SAM domain [ 158526] (2)


Superfamily statistics
Genomes (458) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 15,485 14,406 33
Proteins 13,433 12,441 33


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.020172.076e-15Least InformativeInherited
Biological Process (BP)developmental process0.015647.288e-13Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0040760Least InformativeInherited
Biological Process (BP)nervous system development8.113e-056.702e-12Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.00025799.727e-09Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00040510.0145Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 7.288e-13 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.076e-15 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 5.955e-08 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.2404 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) localization 0.7804 Least Informative Inherited
Biological Process (BP) response to stimulus 0.002091 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.08205 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.01415 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nervous system development 6.702e-12 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 9.727e-09 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 5.656e-06 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 3.731e-11 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 1.235e-08 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 1.201e-07 Moderately Informative Direct
Biological Process (BP) reproduction 4.248e-07 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 5.084e-07 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 9.367e-06 Moderately Informative Direct
Biological Process (BP) regulation of signaling 2.672e-05 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.01512 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.608 Moderately Informative Inherited
Biological Process (BP) system process 0.1277 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5614 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.001911 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.632 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6168 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4838 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.03003 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.1733 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.5817 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.0145 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.006834 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.4631 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 1.53e-14 Informative Direct
Biological Process (BP) locomotion 3.431e-13 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.122e-11 Informative Direct
Biological Process (BP) cellular process involved in reproduction 2.562e-09 Informative Direct
Biological Process (BP) localization of cell 5.201e-08 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 2.512e-07 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 3.293e-06 Informative Direct
Biological Process (BP) single organism reproductive process 4.14e-06 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 5.215e-06 Informative Direct
Biological Process (BP) generation of neurons 6.3e-06 Informative Direct
Biological Process (BP) central nervous system development 9.665e-06 Informative Direct
Biological Process (BP) biological adhesion 9.959e-06 Informative Direct
Biological Process (BP) regulation of ion transport 2.09e-05 Informative Direct
Biological Process (BP) regulation of nervous system development 6.888e-05 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 8.348e-05 Informative Direct
Biological Process (BP) response to external stimulus 8.457e-05 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0002304 Informative Direct
Biological Process (BP) epithelium development 0.0002596 Informative Direct
Biological Process (BP) apoptotic process 0.0003611 Informative Direct
Biological Process (BP) cell cycle process 0.0006547 Informative Direct
Biological Process (BP) sexual reproduction 0.0006574 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0007001 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0007832 Informative Direct
Biological Process (BP) single-organism behavior 0.01826 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.6723 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9614 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.008348 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.4415 Informative Inherited
Biological Process (BP) synaptic transmission 0.006955 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.1917 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.02154 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.002687 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.2752 Informative Inherited
Biological Process (BP) DNA metabolic process 0.005526 Informative Inherited
Biological Process (BP) defense response 0.1484 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) immune effector process 0.08498 Informative Inherited
Biological Process (BP) response to lipid 0.4083 Informative Inherited
Biological Process (BP) positive regulation of transport 0.374 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.008408 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1586 Informative Inherited
Biological Process (BP) regulation of locomotion 0.2859 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00259 Informative Inherited
Biological Process (BP) regulation of cell development 0.1937 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3245 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) cellular component movement 0.01307 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.02496 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.007428 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.04209 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.415 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.04219 Informative Inherited
Biological Process (BP) pigment metabolic process 0.1236 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1128 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.275 Informative Inherited
Biological Process (BP) tube development 0.08959 Informative Inherited
Biological Process (BP) chordate embryonic development 0.9045 Informative Inherited
Biological Process (BP) organ morphogenesis 0.02659 Informative Inherited
Biological Process (BP) sensory organ development 0.6001 Informative Inherited
Biological Process (BP) cardiovascular system development 0.06817 Informative Inherited
Biological Process (BP) peptidyl-tyrosine phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0 Highly Informative Direct
Biological Process (BP) chemotaxis 2.076e-15 Highly Informative Direct
Biological Process (BP) spermatogenesis 3.589e-13 Highly Informative Direct
Biological Process (BP) meiosis 7.896e-12 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 1.451e-11 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 7.414e-10 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 1.079e-07 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 3.231e-07 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 1.185e-06 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 3.591e-06 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 8.588e-05 Highly Informative Direct
Biological Process (BP) membrane lipid biosynthetic process 9.285e-05 Highly Informative Direct
Biological Process (BP) angiogenesis 9.301e-05 Highly Informative Direct
Biological Process (BP) regulation of cell projection organization 0.0002692 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0003792 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0004067 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis 0.0006441 Highly Informative Direct
Biological Process (BP) cell adhesion 0.0007317 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.2718 Highly Informative Inherited
Biological Process (BP) axonogenesis 0.9468 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.06273 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.2064 Highly Informative Inherited
Biological Process (BP) epidermis development 0.5734 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.03102 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.022 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 0.003572 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.1936 Highly Informative Inherited
Biological Process (BP) regulation of neurological system process 0.01001 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1251 Highly Informative Inherited
Biological Process (BP) regulation of Ras protein signal transduction 0.09959 Highly Informative Inherited
Biological Process (BP) innate immune response 0.6844 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.848 Highly Informative Inherited
Biological Process (BP) apoptotic signaling pathway 0.1619 Highly Informative Inherited
Biological Process (BP) learning or memory 0.1015 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.003209 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.01583 Highly Informative Inherited
Biological Process (BP) response to calcium ion 0.00155 Highly Informative Inherited
Biological Process (BP) tube formation 0.007118 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.3625 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.04024 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 1 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 8.47e-09 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.2569 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.001495 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.1712 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.5779 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.6568 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 2.397e-14 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1.139e-07 Informative Direct
Molecular Function (MF) DNA binding 4.322e-05 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 5.963e-05 Informative Direct
Molecular Function (MF) enzyme activator activity 0.0002536 Informative Direct
Molecular Function (MF) kinase activity 0.000425 Informative Direct
Molecular Function (MF) receptor binding 0.1707 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.005484 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 7.656e-06 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 1.805e-05 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.0001022 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0001806 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.00286 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.2113 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 8.944e-05 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.703 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.03759 Least Informative Inherited
Cellular Component (CC) cell projection 1.373e-08 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 3.201e-08 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 3.683e-05 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0008186 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.903 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.003223 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.3023 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.6569 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.8819 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) neuron part 0 Informative Direct
Cellular Component (CC) integral to membrane 4.07e-12 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 2.315e-11 Informative Direct
Cellular Component (CC) synapse 2.274e-09 Informative Direct
Cellular Component (CC) endosome 3.478e-09 Informative Direct
Cellular Component (CC) cell projection part 0.006972 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.2528 Informative Inherited
Cellular Component (CC) chromosome 0.6651 Informative Inherited
Cellular Component (CC) integral to plasma membrane 2.866e-07 Highly Informative Direct
Cellular Component (CC) endosomal part 1.713e-06 Highly Informative Direct
Cellular Component (CC) dendrite 0.000284 Highly Informative Direct
Cellular Component (CC) synaptic membrane 0.0003577 Highly Informative Direct
Cellular Component (CC) intrinsic to endoplasmic reticulum membrane 0.0007962 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.04757 Highly Informative Inherited
Cellular Component (CC) chromatin 0.1093 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.558Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.007561Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.00471Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase1.004e-11InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase9.763e-13Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate group0.01424Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.3517Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.5914Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.07686Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3556Moderately InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.6067Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.7797Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron differentiation0.2935InformativeInherited
Mammalian Phenotype (MP)abnormal tail bud morphology0.0007289Highly InformativeDirect
Mammalian Phenotype (MP)abnormal induced cell death0.03755Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.09433Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.04444Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.000253InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.0002089Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)leaf lamina0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.004781Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.007592Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.07269InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase7.02e-12Highly InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase2.734e-10Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate groups0.01378Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processProtein transport2.185e-05Moderately InformativeDirect
Biological processLipid metabolism0.4537Moderately InformativeInherited
Biological processCell adhesion0InformativeDirect
Biological processMeiosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis8.702e-11InformativeDirect
Biological processTranslation regulation1.066e-06InformativeDirect
Biological processRNA-mediated gene silencing0Highly InformativeDirect
Biological processSphingolipid metabolism4.522e-15Highly InformativeDirect
Biological processSpermatogenesis4.05e-11Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane1.917e-05Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoskeleton7.875e-10Moderately InformativeDirect
Cellular componentEndosome1.058e-08Moderately InformativeDirect
Cellular componentGolgi apparatus0.0003615Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0009081Moderately InformativeDirect
Cellular componentPostsynaptic cell membrane6.059e-13InformativeDirect
Coding sequence diversityAlternative splicing5.49e-06Least InformativeDirect
DiseaseProto-oncogene6.15e-05Moderately InformativeDirect
DiseaseTumor suppressor7.503e-05Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil3.582e-10Moderately InformativeDirect
DomainANK repeat0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding2.878e-10InformativeDirect
DomainSH2 domain3.937e-05InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionDNA-binding1.376e-15Moderately InformativeDirect
Molecular functionZinc-finger4.918e-10Moderately InformativeDirect
Molecular functionCalcium0.2999Moderately InformativeInherited
Molecular functionActin-binding6.095e-05InformativeDirect
Molecular functionCalcium transport3.421e-10Highly InformativeDirect
Post-translational modificationTransferase0.1408Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationActivator1.713e-06Moderately InformativeDirect
Post-translational modificationGTPase activation1.923e-13InformativeDirect
Post-translational modificationChromatin regulator1.44e-06InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010993 SSF47769 Protein matches
Abstract

Sterile alpha motif (SAM) domains are known to be involved in diverse protein-protein interactions, associating with both SAM-containing and non-SAM-containing proteins pathway [PubMed14659692]. SAM domains exhibit a conserved structure, consisting of a 4-5-helical bundle of two orthogonally packed alpha-hairpins. However SAM domains display a diversity of function, being involved in interactions with proteins, DNA and RNA [PubMed12858164]. The name sterile alpha motif arose from its presence in proteins that are essential for yeast sexual differentiation. The SAM domain has had various names, including SPM, PTN (pointed), SEP (yeast sterility, Ets-related, PcG proteins), NCR (N-terminal conserved region) and HLH (helix-loop-helix) domain, all of which are related and can be classified as SAM domains.

SAM domains occur in eukaryotic and in some bacterial proteins. Structures have been determined for several proteins that contain SAM domains, including Ets-1 transcription factor, which plays a role in the development and invasion of tumour cells by regulating the expression of matrix-degrading proteases [PubMed14704859]; Etv6 transcription factor, gene rearrangements of which have been demonstrated in several malignancies [PubMed9031109]; EphA4 receptor tyrosine kinase, which is believed to be important for the correct localization of a motoneuron pool to a specific position in the spinal cord [PubMed12577325]; EphB2 receptor, which is involved in spine morphogenesis via intersectin, Cdc42 and N-Wasp [PubMed12389031]; p73, a p53 homologue involved in neuronal development [PubMed14659698]; and polyhomeotic, which is a member of the Polycomb group of genes (Pc-G) required for the maintenance of the spatial expression pattern of homeotic genes [PubMed14499651].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAM/Pointed domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the SAM/Pointed domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]