SUPERFAMILY 1.75 HMM library and genome assignments server

SAM/Pointed domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   SAM domain-like [ 47768] (16)
Superfamily:   SAM/Pointed domain [ 47769] (3)
Families:   Pointed domain [ 47770] (6)
  SAM (sterile alpha motif) domain [ 47773] (15)
  Variant SAM domain [ 158526] (2)


Superfamily statistics
Genomes (514) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 17,451 18,588 33
Proteins 15,156 16,171 33


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00064740Least InformativeDirect
Biological Process (BP)developmental process0.0031770Least InformativeInherited
Biological Process (BP)single-organism cellular process0.017770.0001144Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0001144 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00001581 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0006683 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.5687 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1407 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.007813 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.5096 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.00000001694 Moderately Informative Direct
Biological Process (BP) nervous system development 0.000000001895 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0000000000003349 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000000003989 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000001934 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000005233 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.000001143 Moderately Informative Direct
Biological Process (BP) reproductive process 0.00001724 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0003418 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0006776 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.2411 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.29 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.0354 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.9794 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) defense response 0.1513 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2552 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.3725 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2779 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7998 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1363 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.05743 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.7223 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.008421 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3577 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.1667 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) phosphorylation 0.000000000000001913 Informative Direct
Biological Process (BP) locomotion 0.0000000000001712 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0000000000158 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.00000000002795 Informative Direct
Biological Process (BP) ncRNA metabolic process 0.000000003687 Informative Direct
Biological Process (BP) cell division 0.00000001077 Informative Direct
Biological Process (BP) cellular component movement 0.00000003306 Informative Direct
Biological Process (BP) localization of cell 0.0000001803 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000004143 Informative Direct
Biological Process (BP) organelle fission 0.00000223 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.000002631 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000003114 Informative Direct
Biological Process (BP) generation of neurons 0.00000549 Informative Direct
Biological Process (BP) biological adhesion 0.00001539 Informative Direct
Biological Process (BP) regulation of ion transport 0.00001656 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00003391 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.00004701 Informative Direct
Biological Process (BP) regulation of MAPK cascade 0.00005954 Informative Direct
Biological Process (BP) single-organism behavior 0.00009041 Informative Direct
Biological Process (BP) amide biosynthetic process 0.0002306 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0003215 Informative Direct
Biological Process (BP) epithelium development 0.0003384 Informative Direct
Biological Process (BP) central nervous system development 0.000372 Informative Direct
Biological Process (BP) apoptotic process 0.0004087 Informative Direct
Biological Process (BP) protein oligomerization 0.0005167 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0008379 Informative Direct
Biological Process (BP) synaptic transmission 0.001802 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.7715 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.03684 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.001109 Informative Inherited
Biological Process (BP) response to lipid 0.5154 Informative Inherited
Biological Process (BP) response to acid chemical 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.8989 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.1708 Informative Inherited
Biological Process (BP) growth 0.2824 Informative Inherited
Biological Process (BP) neurological system process 0.09088 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.2225 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.3775 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9644 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of response to wounding 1 Informative Inherited
Biological Process (BP) tube development 0.0241 Informative Inherited
Biological Process (BP) cardiovascular system development 0.1796 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.0095 Informative Inherited
Biological Process (BP) sensory organ development 0.681 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.1532 Informative Inherited
Biological Process (BP) response to oxidative stress 0.7228 Informative Inherited
Biological Process (BP) immune effector process 0.2143 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.8632 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.02959 Informative Inherited
Biological Process (BP) regulation of locomotion 0.2749 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.002881 Informative Inherited
Biological Process (BP) actin filament-based process 0.002143 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.3743 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.008976 Informative Inherited
Biological Process (BP) regulation of cell development 0.002249 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1279 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) organophosphate catabolic process 1 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.04827 Informative Inherited
Biological Process (BP) sexual reproduction 0.001796 Informative Inherited
Biological Process (BP) single organism reproductive process 0.00456 Informative Inherited
Biological Process (BP) cell cycle process 0.9869 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.006493 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.4838 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.09352 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1782 Informative Inherited
Biological Process (BP) secondary metabolic process 0.6782 Informative Inherited
Biological Process (BP) pigment metabolic process 0.1384 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.05113 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.05343 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.8978 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.02238 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 0 Highly Informative Direct
Biological Process (BP) DNA modification 0 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000000000008678 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.000000000001727 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.000000001363 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.000000002486 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.000000003266 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.000000004512 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00000001776 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.00000002269 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00000002591 Highly Informative Direct
Biological Process (BP) cell recognition 0.00000003162 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0000001354 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0.000000216 Highly Informative Direct
Biological Process (BP) cell adhesion 0.0000009681 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.00000191 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.000002551 Highly Informative Direct
Biological Process (BP) regulation of ion transmembrane transport 0.000002627 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 0.000002942 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000006106 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 0.00000946 Highly Informative Direct
Biological Process (BP) neuron projection development 0.00002251 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.00002317 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0.00004821 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0001653 Highly Informative Direct
Biological Process (BP) deoxyribonucleotide metabolic process 0.0001948 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.0002871 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0003123 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000495 Highly Informative Direct
Biological Process (BP) deoxyribose phosphate metabolic process 0.0009023 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.4277 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.1706 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.1535 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.02339 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.5644 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.7072 Highly Informative Inherited
Biological Process (BP) developmental growth 1 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.117 Highly Informative Inherited
Biological Process (BP) epidermis development 0.1419 Highly Informative Inherited
Biological Process (BP) negative regulation of response to wounding 0.1216 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.434 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1294 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.01422 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.01962 Highly Informative Inherited
Biological Process (BP) innate immune response 0.8527 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.001162 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.9059 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.009179 Highly Informative Inherited
Biological Process (BP) learning or memory 0.1828 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) nuclear division 0.003529 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.01745 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.08986 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.2635 Highly Informative Inherited
Biological Process (BP) response to calcium ion 0.001969 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.002558 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.009217 Highly Informative Inherited
Biological Process (BP) neural tube development 0.02146 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 8.141e-16 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.0000008095 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.6858 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.1305 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.05783 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0.000000000000007683 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0.00000004197 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000005766 Informative Direct
Molecular Function (MF) DNA binding 0.0001024 Informative Direct
Molecular Function (MF) kinase activity 0.0003489 Informative Direct
Molecular Function (MF) chromatin binding 0.0007567 Informative Direct
Molecular Function (MF) receptor binding 0.266 Informative Inherited
Molecular Function (MF) nucleotide binding 0.5729 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.003885 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0000000000003796 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.00000007126 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.000002004 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.00001565 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.00542 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 0.001074 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.001669 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.4578 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.0002793 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 0.01469 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.8554 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.0000001461 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000001095 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.00001076 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.00007288 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.0003933 Moderately Informative Direct
Cellular Component (CC) membrane region 0.1186 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.2574 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.8758 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) synapse 0.00000000000002302 Informative Direct
Cellular Component (CC) integral component of membrane 0.00000000432 Informative Direct
Cellular Component (CC) endosome 0.000000004403 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.000000006834 Informative Direct
Cellular Component (CC) plasma membrane region 0.2456 Informative Inherited
Cellular Component (CC) neuron projection 0.01183 Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.005259 Informative Inherited
Cellular Component (CC) cell junction 0.03345 Informative Inherited
Cellular Component (CC) chromosome 0.7212 Informative Inherited
Cellular Component (CC) cytoplasmic ribonucleoprotein granule 0 Highly Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 0.0000000001045 Highly Informative Direct
Cellular Component (CC) integral component of plasma membrane 0.0000000004983 Highly Informative Direct
Cellular Component (CC) postsynaptic membrane 0.0000004551 Highly Informative Direct
Cellular Component (CC) endosomal part 0.000009051 Highly Informative Direct
Cellular Component (CC) integral component of organelle membrane 0.00004257 Highly Informative Direct
Cellular Component (CC) ciliary part 0.05274 Highly Informative Inherited
Cellular Component (CC) cell projection membrane 0.307 Highly Informative Inherited
Cellular Component (CC) dendrite 0.002448 Highly Informative Inherited
Cellular Component (CC) adherens junction 0.7471 Highly Informative Inherited
Cellular Component (CC) chromatin 0.02435 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.1118 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.558Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.007561Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.00471Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.00000000001004InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase0.0000000000009763Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate group0.01424Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.3131Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.5795Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.301Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.3244Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.1609InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.09433Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.04444Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.000253InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.0002089Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.004286Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.007925Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.02022InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.000000000001337Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.000000000007567Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate groups0.009692Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processProtein transport0.00002978Moderately InformativeDirect
Biological processLipid metabolism0.4695Moderately InformativeInherited
Biological processIon transport0.8193Moderately InformativeInherited
Biological processCell adhesion0InformativeDirect
Biological processMeiosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis0.0000000002223InformativeDirect
Biological processTranslation regulation0.000001431InformativeDirect
Biological processRNA-mediated gene silencing0Highly InformativeDirect
Biological processSphingolipid metabolism0.00000000000001226Highly InformativeDirect
Biological processSpermatogenesis0.000000000001686Highly InformativeDirect
Biological processCalcium transport0.0000000004214Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.00004333Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.000000002114Moderately InformativeDirect
Cellular componentCytoskeleton0.000000005161Moderately InformativeDirect
Cellular componentGolgi apparatus0.0006372Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.00000002019Least InformativeDirect
Coding sequence diversityAlternative promoter usage0.0000007556Moderately InformativeDirect
DiseaseProto-oncogene0.00009155Moderately InformativeDirect
DiseaseTumor suppressor0.0001404Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0.0000000005463Moderately InformativeDirect
DomainANK repeat0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.0000000002693InformativeDirect
DomainSH2 domain0.00003351InformativeDirect
Molecular functionDNA-binding0.000000000000005461Least InformativeDirect
Molecular functionZinc0.0005202Least InformativeDirect
Molecular functionActin-binding0.000000429InformativeDirect
Post-translational modificationTransferase0.1461Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationActivator0.000002085Moderately InformativeDirect
Post-translational modificationGTPase activation0.0000000000002304InformativeDirect
Post-translational modificationChromatin regulator0.000000005274InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00002202Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010993 SSF47769 Protein matches
Abstract

Sterile alpha motif (SAM) domains are known to be involved in diverse protein-protein interactions, associating with both SAM-containing and non-SAM-containing proteins pathway [PubMed14659692]. SAM domains exhibit a conserved structure, consisting of a 4-5-helical bundle of two orthogonally packed alpha-hairpins. However SAM domains display a diversity of function, being involved in interactions with proteins, DNA and RNA [PubMed12858164]. The name sterile alpha motif arose from its presence in proteins that are essential for yeast sexual differentiation. The SAM domain has had various names, including SPM, PTN (pointed), SEP (yeast sterility, Ets-related, PcG proteins), NCR (N-terminal conserved region) and HLH (helix-loop-helix) domain, all of which are related and can be classified as SAM domains.

SAM domains occur in eukaryotic and in some bacterial proteins. Structures have been determined for several proteins that contain SAM domains, including Ets-1 transcription factor, which plays a role in the development and invasion of tumour cells by regulating the expression of matrix-degrading proteases [PubMed14704859]; Etv6 transcription factor, gene rearrangements of which have been demonstrated in several malignancies [PubMed9031109]; EphA4 receptor tyrosine kinase, which is believed to be important for the correct localization of a motoneuron pool to a specific position in the spinal cord [PubMed12577325]; EphB2 receptor, which is involved in spine morphogenesis via intersectin, Cdc42 and N-Wasp [PubMed12389031]; p73, a p53 homologue involved in neuronal development [PubMed14659698]; and polyhomeotic, which is a member of the Polycomb group of genes (Pc-G) required for the maintenance of the spatial expression pattern of homeotic genes [PubMed14499651].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAM/Pointed domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the SAM/Pointed domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]