SUPERFAMILY 1.75 HMM library and genome assignments server


SAM/Pointed domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   SAM domain-like [ 47768] (16)
Superfamily:   SAM/Pointed domain [ 47769] (3)
Families:   Pointed domain [ 47770] (6)
  SAM (sterile alpha motif) domain [ 47773] (15)
  Variant SAM domain [ 158526] (2)


Superfamily statistics
Genomes (463) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 15,775 14,406 33
Proteins 13,679 12,441 33


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0014980Least InformativeInherited
Biological Process (BP)single-organism cellular process0.006770Least InformativeInherited
Biological Process (BP)developmental process0.0078880Least InformativeInherited
Biological Process (BP)nervous system development3.237e-052.474e-11Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.00010041.664e-07Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00018040.01069Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 3.217e-13 Least Informative Direct
Biological Process (BP) response to stimulus 1.123e-05 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0002171 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.3912 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) localization 0.4392 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.004288 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nervous system development 2.474e-11 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1.664e-07 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 5.33e-06 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 2.324e-11 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 2.963e-10 Moderately Informative Direct
Biological Process (BP) reproduction 3.19e-09 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 5.242e-08 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 7.124e-05 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0001287 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.002648 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2012 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1362 Moderately Informative Inherited
Biological Process (BP) system process 0.1149 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2948 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.679 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.9619 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.9025 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2918 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.07711 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.286 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8051 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1578 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.01069 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.006211 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.9914 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.336 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.9519 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) regulation of nucleotide catabolic process 7.333e-15 Informative Direct
Biological Process (BP) cell projection organization 2.78e-14 Informative Direct
Biological Process (BP) phosphorylation 8.122e-14 Informative Direct
Biological Process (BP) locomotion 8.593e-14 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 1.065e-12 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 3.401e-12 Informative Direct
Biological Process (BP) cellular process involved in reproduction 3.009e-10 Informative Direct
Biological Process (BP) cellular component morphogenesis 7.466e-10 Informative Direct
Biological Process (BP) ncRNA metabolic process 2.186e-09 Informative Direct
Biological Process (BP) localization of cell 1.453e-08 Informative Direct
Biological Process (BP) single organism reproductive process 3.719e-08 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 1.013e-07 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 4.611e-07 Informative Direct
Biological Process (BP) regulation of organelle organization 1.967e-06 Informative Direct
Biological Process (BP) biological adhesion 4.291e-06 Informative Direct
Biological Process (BP) cellular component movement 4.303e-06 Informative Direct
Biological Process (BP) regulation of ion transport 1.075e-05 Informative Direct
Biological Process (BP) generation of neurons 1.175e-05 Informative Direct
Biological Process (BP) single-organism behavior 1.61e-05 Informative Direct
Biological Process (BP) sexual reproduction 4.093e-05 Informative Direct
Biological Process (BP) epithelium development 5.02e-05 Informative Direct
Biological Process (BP) central nervous system development 5.845e-05 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0002006 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0004117 Informative Direct
Biological Process (BP) cell cycle process 0.0004224 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0005722 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0007694 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.8504 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.8852 Informative Inherited
Biological Process (BP) cell-cell signaling 0.03389 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01448 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.7227 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.8543 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.0194 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.2212 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.02431 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.001822 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.03338 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.9447 Informative Inherited
Biological Process (BP) DNA metabolic process 0.01761 Informative Inherited
Biological Process (BP) organ morphogenesis 0.009925 Informative Inherited
Biological Process (BP) defense response 0.1678 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) immune effector process 0.1349 Informative Inherited
Biological Process (BP) secondary metabolic process 0.6055 Informative Inherited
Biological Process (BP) response to lipid 0.3847 Informative Inherited
Biological Process (BP) positive regulation of transport 0.554 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.2859 Informative Inherited
Biological Process (BP) regulation of locomotion 0.4737 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.02851 Informative Inherited
Biological Process (BP) regulation of cell development 0.007829 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.9988 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) response to oxidative stress 0.5833 Informative Inherited
Biological Process (BP) cell death 0.1761 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.01976 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.02387 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.004729 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1225 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.3757 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.04877 Informative Inherited
Biological Process (BP) pigment metabolic process 0.1199 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1179 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.09834 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.3883 Informative Inherited
Biological Process (BP) sensory organ development 0.7766 Informative Inherited
Biological Process (BP) cardiovascular system development 0.1451 Informative Inherited
Biological Process (BP) spermatogenesis 0 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) DNA modification 0 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 2.933e-13 Highly Informative Direct
Biological Process (BP) meiosis 3.301e-11 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 1.317e-09 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 2.305e-08 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 2.57e-08 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 6.992e-08 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 1.249e-07 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 2.128e-07 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 6.109e-07 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 1.199e-06 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 1.536e-06 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 2.459e-06 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 3.821e-06 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 5.368e-06 Highly Informative Direct
Biological Process (BP) multi-organism behavior 8.604e-06 Highly Informative Direct
Biological Process (BP) neuron projection development 3.069e-05 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 4.526e-05 Highly Informative Direct
Biological Process (BP) deoxyribonucleotide metabolic process 0.0001148 Highly Informative Direct
Biological Process (BP) amide biosynthetic process 0.0001196 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0001395 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0002035 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0003353 Highly Informative Direct
Biological Process (BP) deoxyribose phosphate metabolic process 0.0004594 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.000595 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0006756 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0008247 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.229 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.4359 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.1914 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.4111 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.05213 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.4205 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.03257 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1577 Highly Informative Inherited
Biological Process (BP) innate immune response 0.7013 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.001024 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.2025 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.01124 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.00271 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.01401 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.6105 Highly Informative Inherited
Biological Process (BP) response to calcium ion 0.001367 Highly Informative Inherited
Biological Process (BP) tube formation 0.007146 Highly Informative Inherited
Biological Process (BP) neural tube development 0.01093 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.4352 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.07504 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 1 Highly Informative Inherited
Molecular Function (MF) binding 4.534e-15 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 5.044e-05 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.08987 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.7138 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.1741 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 5.282e-15 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1.427e-07 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 1.138e-05 Informative Direct
Molecular Function (MF) DNA binding 2.53e-05 Informative Direct
Molecular Function (MF) enzyme activator activity 0.000341 Informative Direct
Molecular Function (MF) chromatin binding 0.0005324 Informative Direct
Molecular Function (MF) kinase activity 0.0006436 Informative Direct
Molecular Function (MF) receptor binding 0.2172 Informative Inherited
Molecular Function (MF) nucleotide binding 0.4431 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.008713 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) protein kinase activity 1.412e-07 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 6.091e-07 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 2.519e-05 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0003409 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.003022 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.001162 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.001905 Highly Informative Inherited
Cellular Component (CC) membrane 0.0003367 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0004842 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.7485 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 1.962e-09 Moderately Informative Direct
Cellular Component (CC) cell projection 1.157e-06 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 6.121e-06 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.00014 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.8264 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.02117 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.9509 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 1.959e-14 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 1.194e-09 Informative Direct
Cellular Component (CC) endosome 1.838e-08 Informative Direct
Cellular Component (CC) synapse part 2.852e-08 Informative Direct
Cellular Component (CC) neuron projection 0.0003338 Informative Direct
Cellular Component (CC) chromosome 0.6498 Informative Inherited
Cellular Component (CC) integral to plasma membrane 1.23e-06 Highly Informative Direct
Cellular Component (CC) neuron spine 3.028e-06 Highly Informative Direct
Cellular Component (CC) endosomal part 6.325e-06 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 7.599e-05 Highly Informative Direct
Cellular Component (CC) synaptic membrane 0.0001658 Highly Informative Direct
Cellular Component (CC) dendrite 0.0002633 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 0.0007072 Highly Informative Direct
Cellular Component (CC) early endosome 0.0009522 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.2145 Highly Informative Inherited
Cellular Component (CC) cilium 0.3341 Highly Informative Inherited
Cellular Component (CC) adherens junction 0.811 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.1027 Highly Informative Inherited
Cellular Component (CC) chromatin 0.08234 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.558Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.007561Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.00471Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase1.004e-11InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase9.763e-13Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate group0.01424Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.4327Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.5431Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3147Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.3554Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.6957Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal induced cell death0.04271InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.1737InformativeInherited
Mammalian Phenotype (MP)decreased sensitivity to induced cell death0.0008042Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.09433Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.04444Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.000253InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.0002089Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.004313Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00835Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.02053InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase1.46e-12Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase7.551e-12Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate groups0.00982Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processProtein transport2.996e-05Moderately InformativeDirect
Biological processLipid metabolism0.4669Moderately InformativeInherited
Biological processIon transport0.8192Moderately InformativeInherited
Biological processCell adhesion0InformativeDirect
Biological processMeiosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis2.296e-10InformativeDirect
Biological processTranslation regulation1.479e-06InformativeDirect
Biological processRNA-mediated gene silencing0Highly InformativeDirect
Biological processSphingolipid metabolism1.001e-14Highly InformativeDirect
Biological processSpermatogenesis1.236e-12Highly InformativeDirect
Biological processCalcium transport4.423e-10Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane4.889e-05Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome1.895e-09Moderately InformativeDirect
Cellular componentCytoskeleton4.808e-09Moderately InformativeDirect
Cellular componentGolgi apparatus0.0006121Moderately InformativeDirect
Coding sequence diversityAlternative splicing1.501e-05Least InformativeDirect
Coding sequence diversityAlternative promoter usage4.242e-07Moderately InformativeDirect
DiseaseProto-oncogene0.0001116Moderately InformativeDirect
DiseaseTumor suppressor0.0001671Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil4.442e-10Moderately InformativeDirect
DomainANK repeat0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding2.916e-10InformativeDirect
DomainSH2 domain3.547e-05InformativeDirect
Molecular functionDNA-binding2.29e-15Least InformativeDirect
Molecular functionZinc0.0004155Least InformativeDirect
Molecular functionActin-binding3.939e-07InformativeDirect
Post-translational modificationTransferase0.1503Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationActivator2.074e-06Moderately InformativeDirect
Post-translational modificationGTPase activation2.901e-13InformativeDirect
Post-translational modificationChromatin regulator4.403e-09InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation1.53e-05Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010993 SSF47769 Protein matches
Abstract

Sterile alpha motif (SAM) domains are known to be involved in diverse protein-protein interactions, associating with both SAM-containing and non-SAM-containing proteins pathway [PubMed14659692]. SAM domains exhibit a conserved structure, consisting of a 4-5-helical bundle of two orthogonally packed alpha-hairpins. However SAM domains display a diversity of function, being involved in interactions with proteins, DNA and RNA [PubMed12858164]. The name sterile alpha motif arose from its presence in proteins that are essential for yeast sexual differentiation. The SAM domain has had various names, including SPM, PTN (pointed), SEP (yeast sterility, Ets-related, PcG proteins), NCR (N-terminal conserved region) and HLH (helix-loop-helix) domain, all of which are related and can be classified as SAM domains.

SAM domains occur in eukaryotic and in some bacterial proteins. Structures have been determined for several proteins that contain SAM domains, including Ets-1 transcription factor, which plays a role in the development and invasion of tumour cells by regulating the expression of matrix-degrading proteases [PubMed14704859]; Etv6 transcription factor, gene rearrangements of which have been demonstrated in several malignancies [PubMed9031109]; EphA4 receptor tyrosine kinase, which is believed to be important for the correct localization of a motoneuron pool to a specific position in the spinal cord [PubMed12577325]; EphB2 receptor, which is involved in spine morphogenesis via intersectin, Cdc42 and N-Wasp [PubMed12389031]; p73, a p53 homologue involved in neuronal development [PubMed14659698]; and polyhomeotic, which is a member of the Polycomb group of genes (Pc-G) required for the maintenance of the spatial expression pattern of homeotic genes [PubMed14499651].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAM/Pointed domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the SAM/Pointed domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]