SUPERFAMILY 1.75 HMM library and genome assignments server


PAH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   PAH2 domain [ 47761]
Superfamily:   PAH2 domain [ 47762]
Families:   PAH2 domain [ 47763] (2)


Superfamily statistics
Genomes (441) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,330 3,199 3
Proteins 1,480 1,401 3


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0.00000002459 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000000182 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.000005252 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00005839 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.002677 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.01504 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.04118 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.005064 Least Informative Inherited
Biological Process (BP) localization 0.01121 Least Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.0000000008561 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0.000000005434 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.000000009254 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.000000009831 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000002642 Moderately Informative Direct
Biological Process (BP) immune system process 0.00009136 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.004184 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.5701 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8214 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.07063 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.07474 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.001103 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2953 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1579 Moderately Informative Inherited
Biological Process (BP) organ development 0.003941 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.8234 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.001483 Moderately Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.000000002767 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.00000002721 Informative Direct
Biological Process (BP) chromosome organization 0.000008136 Informative Direct
Biological Process (BP) locomotion 0.00001099 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00005119 Informative Direct
Biological Process (BP) regulation of locomotion 0.00005346 Informative Direct
Biological Process (BP) localization of cell 0.0005368 Informative Direct
Biological Process (BP) generation of neurons 0.9162 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1629 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.006158 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.001798 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01396 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02239 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.03034 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.003863 Informative Inherited
Biological Process (BP) cell projection organization 0.009913 Informative Inherited
Biological Process (BP) muscle structure development 0.001241 Informative Inherited
Biological Process (BP) cellular component movement 0.02996 Informative Inherited
Biological Process (BP) protein deacylation 0.000000000007299 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.00000004193 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0000001263 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.000003471 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000003914 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.000008498 Highly Informative Direct
Biological Process (BP) aging 0.00001406 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.00003741 Highly Informative Direct
Biological Process (BP) histone modification 0.0002946 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0005168 Highly Informative Direct
Molecular Function (MF) binding 0.001052 Least Informative Inherited
Molecular Function (MF) chromatin binding 0.0000303 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00637 Informative Inherited
Molecular Function (MF) protein heterodimerization activity 0.00000003114 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.000003088 Least Informative Direct
Cellular Component (CC) protein complex 0.000004465 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0005907 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.831 Least Informative Inherited
Cellular Component (CC) nuclear part 0.000004996 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.00003338 Moderately Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) nucleoplasm part 0.00000001458 Informative Direct
Cellular Component (CC) histone deacetylase complex 0 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.0000001336 Highly Informative Direct
Cellular Component (CC) chromatin 0.008996 Highly Informative Inherited

Document: GO annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainRepeat0Least InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.0000432Least InformativeDirect
Post-translational modificationUbl conjugation0.0000008589Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003822 SSF47762 Protein matches
Abstract

This family contains the paired amphipathic helix (PAH) repeat. The family contains the eukaryotic Sin3 proteins, which have at least three PAH domains (PAH1, PAH2, and PAH3). Sin3 proteins are components of a co-repressor complex that silences transcription, playing important roles in the transition between proliferation and differentiation. Sin3 proteins are recruited to the DNA by various DNA-binding transcription factors such as the Mad family of repressors, Mnt/Rox, PLZF, MeCP2, p53, REST/NRSF, MNFbeta, Sp1, TGIF and Ume6 [PubMed11101889]. Sin3 acts as a scaffold protein that in turn recruits histone-binding proteins RbAp46/RbAp48 and histone deacetylases HDAC1/HDAC2, which deacetylate the core histones resulting in a repressed state of the chromatin [PubMed14705930]. The PAH domains are protein-protein interaction domains through which Sin3 fulfils its role as a scaffold. The PAH2 domain of Sin3 can interact with a wide range of unrelated and structurally diverse transcription factors that bind using different interaction motifs. For example, the Sin3 PAH2 domain can interact with the unrelated Mad and HBP1 factors using alternative interaction motifs that involve binding in opposite helical orientations [PubMed15235594].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PAH2 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the PAH2 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]