SUPERFAMILY 1.75 HMM library and genome assignments server


p53 tetramerization domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   p53 tetramerization domain [ 47718]
Superfamily:   p53 tetramerization domain [ 47719]
Families:   p53 tetramerization domain [ 47720]


Superfamily statistics
Genomes (77) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 311 405 6
Proteins 311 405 6


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.087e-13 Least Informative Direct
Biological Process (BP) single-organism cellular process 6.692e-09 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 4.096e-05 Least Informative Direct
Biological Process (BP) biosynthetic process 0.7652 Least Informative Inherited
Biological Process (BP) localization 0.005095 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.4735 Least Informative Inherited
Biological Process (BP) regulation of programmed cell death 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) organ development 4.442e-13 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 5.1e-13 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1.586e-11 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 4.017e-11 Moderately Informative Direct
Biological Process (BP) cell differentiation 3.353e-09 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 4.371e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0001337 Moderately Informative Direct
Biological Process (BP) immune system process 0.000147 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0003496 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0008552 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.354 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.005303 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001148 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.004757 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.3964 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.07294 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.005433 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1176 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.8628 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.001436 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1291 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.05954 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5562 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.2112 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.2244 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.2352 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.3531 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.4965 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.001877 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.04459 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01149 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.003399 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7976 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.009575 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.2174 Moderately Informative Inherited
Biological Process (BP) gene expression 0.5016 Moderately Informative Inherited
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0 Informative Direct
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 2.725e-13 Informative Direct
Biological Process (BP) regulation of growth 9.182e-13 Informative Direct
Biological Process (BP) mitochondrion organization 3.631e-10 Informative Direct
Biological Process (BP) generation of neurons 1.126e-09 Informative Direct
Biological Process (BP) transcription, DNA-dependent 2.301e-08 Informative Direct
Biological Process (BP) positive regulation of gene expression 7.613e-08 Informative Direct
Biological Process (BP) protein transport 1.288e-07 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1.417e-07 Informative Direct
Biological Process (BP) intracellular signal transduction 2.184e-07 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 4.416e-07 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1.54e-06 Informative Direct
Biological Process (BP) leukocyte activation 3.956e-06 Informative Direct
Biological Process (BP) central nervous system development 4.711e-06 Informative Direct
Biological Process (BP) cellular membrane organization 7.29e-06 Informative Direct
Biological Process (BP) immune effector process 7.62e-06 Informative Direct
Biological Process (BP) growth 7.898e-06 Informative Direct
Biological Process (BP) cell cycle process 1.663e-05 Informative Direct
Biological Process (BP) negative regulation of cell death 2.192e-05 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 2.305e-05 Informative Direct
Biological Process (BP) regulation of body fluid levels 2.561e-05 Informative Direct
Biological Process (BP) negative regulation of developmental process 9.139e-05 Informative Direct
Biological Process (BP) chromosome organization 0.0001042 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0001126 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.000161 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0001648 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0005673 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0.1293 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.006164 Informative Inherited
Biological Process (BP) regulation of cell development 0.313 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.04713 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.3056 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9343 Informative Inherited
Biological Process (BP) organ morphogenesis 0.841 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.4323 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1385 Informative Inherited
Biological Process (BP) protein localization to organelle 0.00336 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.1104 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.3793 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.004463 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01652 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.007772 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01043 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.01031 Informative Inherited
Biological Process (BP) response to light stimulus 0.1682 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.01367 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.174 Informative Inherited
Biological Process (BP) immune response 0.02307 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.02476 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.03111 Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0 Highly Informative Direct
Biological Process (BP) response to UV 0 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 3.77e-15 Highly Informative Direct
Biological Process (BP) regulation of autophagy 7.377e-15 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 7.377e-15 Highly Informative Direct
Biological Process (BP) B cell activation 2.125e-14 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 7.054e-14 Highly Informative Direct
Biological Process (BP) T cell differentiation 3.636e-13 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 5.245e-13 Highly Informative Direct
Biological Process (BP) mitochondrial transport 4.447e-12 Highly Informative Direct
Biological Process (BP) response to salt stress 8.127e-12 Highly Informative Direct
Biological Process (BP) response to drug 3.232e-11 Highly Informative Direct
Biological Process (BP) nuclear import 5.735e-10 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 5.971e-10 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 2.487e-09 Highly Informative Direct
Biological Process (BP) protein import 6.955e-09 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 1.283e-08 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 3.7e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 6.452e-08 Highly Informative Direct
Biological Process (BP) cellular response to radiation 2.133e-07 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 3.437e-07 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 3.541e-07 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 4.035e-07 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 1.132e-06 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 1.599e-06 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 3.629e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 1.767e-05 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 2.85e-05 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0001115 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.0002257 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0003942 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.0004189 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0004263 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.01006 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.007038 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.003226 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.12 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.05237 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.008196 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 2.051e-06 Moderately Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0 Informative Direct
Molecular Function (MF) transition metal ion binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) chromatin binding 2.044e-11 Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 8.121e-12 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 3.153e-07 Least Informative Direct
Cellular Component (CC) intracellular organelle part 3.324e-05 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.1178 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 2.972e-10 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.0001534 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.002404 Moderately Informative Inherited
Cellular Component (CC) nucleolus 1.999e-09 Informative Direct
Cellular Component (CC) mitochondrial matrix 0.000857 Informative Direct
Cellular Component (CC) chromosome 0.006034 Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)immune system disease0Least InformativeDirect
Disease Ontology (DO)nervous system disease0Least InformativeDirect
Disease Ontology (DO)hematopoietic system disease0Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0Moderately InformativeDirect
Disease Ontology (DO)musculoskeletal system cancer0Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0Moderately InformativeDirect
Disease Ontology (DO)sensory system disease0Moderately InformativeDirect
Disease Ontology (DO)disease of mental health0Moderately InformativeDirect
Disease Ontology (DO)genetic disease0Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)autosomal dominant disease0InformativeDirect
Disease Ontology (DO)substance dependence0InformativeDirect
Disease Ontology (DO)lung carcinoma0InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0InformativeDirect
Disease Ontology (DO)viral infectious disease0InformativeDirect
Disease Ontology (DO)connective tissue cancer0InformativeDirect
Disease Ontology (DO)endocrine gland cancer0InformativeDirect
Disease Ontology (DO)chronic leukemia0InformativeDirect
Disease Ontology (DO)liver carcinoma0InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0InformativeDirect
Disease Ontology (DO)melanoma0InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal tumor incidence0Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0InformativeDirect
Mammalian Phenotype (MP)abnormal cartilage morphology0InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0InformativeDirect
Mammalian Phenotype (MP)abnormal facial morphology0InformativeDirect
Mammalian Phenotype (MP)increased malignant tumor incidence0InformativeDirect
Mammalian Phenotype (MP)abnormal sex gland morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal total tissue mass0InformativeDirect
Mammalian Phenotype (MP)abnormal voluntary movement0InformativeDirect
Mammalian Phenotype (MP)premature death0InformativeDirect
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0InformativeDirect
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)hemorrhage0InformativeDirect
Mammalian Phenotype (MP)abnormal intestine morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0InformativeDirect
Mammalian Phenotype (MP)abnormal cranium morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal cell morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal induced cell death0InformativeDirect
Mammalian Phenotype (MP)decreased body weight0Highly InformativeDirect
Mammalian Phenotype (MP)increased sarcoma incidence0Highly InformativeDirect
Mammalian Phenotype (MP)decreased sensitivity to induced cell death0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell nucleus morphology0Highly InformativeDirect
Mammalian Phenotype (MP)premature aging0Highly InformativeDirect
Mammalian Phenotype (MP)increased T cell derived lymphoma incidence0Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis0Highly InformativeDirect
Mammalian Phenotype (MP)increased adenoma incidence0Highly InformativeDirect
Mammalian Phenotype (MP)increased adenocarcinoma incidence0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0Highly InformativeDirect
Mammalian Phenotype (MP)altered metastatic potential0Highly InformativeDirect
Mammalian Phenotype (MP)increased leukemia incidence0Highly InformativeDirect

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processCell cycle0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm6.036e-07Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion3.804e-15Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage1.577e-12Moderately InformativeDirect
DiseaseTumor suppressor0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationPhosphoprotein8.046e-12Least InformativeDirect
Post-translational modificationAcetylation4.503e-06Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationMethylation8.254e-14Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010991 SSF47719 Protein matches
Abstract

The p53 protein is a tetrameric transcription factor that plays a central role in the prevention of neoplastic transformation [PubMed7878469]. Oligomerization appears to be essential for the tumour suppressing activity of p53. p53 can be divided into different functional domains: an N-terminal transactivation domain, a proline-rich domain, a DNA-binding domain , a tetramerisation domain and a C-terminal regulatory region. The tetramerisation domain of human p53 extends from residues 325 to 356, and has a 4-helical bundle fold. The tetramerisation domain is essential for DNA binding, protein-protein interactions, post-translational modifications, and p53 degradation [PubMed11420672].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53 tetramerization domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the p53 tetramerization domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]