SUPERFAMILY 1.75 HMM library and genome assignments server


p53 tetramerization domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   p53 tetramerization domain [ 47718]
Superfamily:   p53 tetramerization domain [ 47719]
Families:   p53 tetramerization domain [ 47720]


Superfamily statistics
Genomes (72) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 285 405 6
Proteins 285 405 6


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000000000002766 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000001028 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00007515 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.5464 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7694 Least Informative Inherited
Biological Process (BP) localization 0.009497 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.00000000000008236 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00000000000126 Moderately Informative Direct
Biological Process (BP) organ development 0.000000000001586 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000000001816 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00000000003285 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00000001045 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0.00006962 Moderately Informative Direct
Biological Process (BP) immune system process 0.00009972 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0006286 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0006311 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0006356 Moderately Informative Direct
Biological Process (BP) organelle organization 0.009548 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.002487 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.007881 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.05502 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.004952 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1008 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.822 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.001907 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1129 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.04817 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6294 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.461 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.2116 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.2264 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.2371 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.3553 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.4929 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.001634 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.02258 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.009027 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.005847 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7297 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.01153 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.2226 Moderately Informative Inherited
Biological Process (BP) gene expression 0.4975 Moderately Informative Inherited
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) programmed cell death 0 Informative Direct
Biological Process (BP) regulation of growth 0.0000000000005067 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.0000000000005781 Informative Direct
Biological Process (BP) mitochondrion organization 0.000000002384 Informative Direct
Biological Process (BP) generation of neurons 0.00000000685 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0.00000001603 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00000003484 Informative Direct
Biological Process (BP) protein transport 0.00000009038 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0000001826 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.000000337 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0000009765 Informative Direct
Biological Process (BP) growth 0.00000201 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000003172 Informative Direct
Biological Process (BP) leukocyte activation 0.000003918 Informative Direct
Biological Process (BP) cellular membrane organization 0.000005384 Informative Direct
Biological Process (BP) immune effector process 0.000007684 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.000008958 Informative Direct
Biological Process (BP) central nervous system development 0.00001599 Informative Direct
Biological Process (BP) chromosome organization 0.00003005 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0000581 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.00006144 Informative Direct
Biological Process (BP) cell cycle process 0.00006422 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.00006557 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0001458 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0001484 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0001769 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0003968 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0.06165 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.00614 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.04585 Informative Inherited
Biological Process (BP) regulation of cell development 0.315 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.2834 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.01454 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9963 Informative Inherited
Biological Process (BP) organ morphogenesis 0.8126 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1484 Informative Inherited
Biological Process (BP) protein localization to organelle 0.003684 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.09795 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.2387 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.003161 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.03022 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01557 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01967 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.008444 Informative Inherited
Biological Process (BP) regulation of response to stress 0.4164 Informative Inherited
Biological Process (BP) response to light stimulus 0.168 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.0164 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.09973 Informative Inherited
Biological Process (BP) immune response 0.01956 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01891 Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0 Highly Informative Direct
Biological Process (BP) response to UV 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.000000000000003722 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.000000000000005546 Highly Informative Direct
Biological Process (BP) B cell activation 0.00000000000001422 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.00000000000004724 Highly Informative Direct
Biological Process (BP) T cell differentiation 0.0000000000002081 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.0000000000003476 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.000000000001104 Highly Informative Direct
Biological Process (BP) response to salt stress 0.000000000005493 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.0000000001603 Highly Informative Direct
Biological Process (BP) nuclear import 0.0000000001985 Highly Informative Direct
Biological Process (BP) protein import 0.00000000244 Highly Informative Direct
Biological Process (BP) response to drug 0.000000002596 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 0.00000001544 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.00000002898 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.00000003275 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00000007682 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0.0000002167 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.0000003252 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.0000006122 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.00000076 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0000008562 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.000003326 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.00001307 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0.00002534 Highly Informative Direct
Biological Process (BP) pattern specification process 0.00008635 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.00009499 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0002478 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0003145 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.008526 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.007048 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.09433 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.0435 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.01587 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.000001394 Moderately Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0 Informative Direct
Molecular Function (MF) transition metal ion binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) chromatin binding 0.00000000001239 Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.000000000003027 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0000001278 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00001639 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.07682 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0000000003085 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.0001574 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.001602 Moderately Informative Inherited
Cellular Component (CC) mitochondrial matrix 0.0008395 Informative Direct
Cellular Component (CC) chromosome 0.00569 Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)immune system disease0Least InformativeDirect
Disease Ontology (DO)nervous system disease0Least InformativeDirect
Disease Ontology (DO)sensory system disease0Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0Moderately InformativeDirect
Disease Ontology (DO)disease of mental health0Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0Moderately InformativeDirect
Disease Ontology (DO)genetic disease0Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0Moderately InformativeDirect
Disease Ontology (DO)autosomal dominant disease0InformativeDirect
Disease Ontology (DO)chronic leukemia0InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0InformativeDirect
Disease Ontology (DO)endocrine gland cancer0InformativeDirect
Disease Ontology (DO)melanoma0InformativeDirect
Disease Ontology (DO)connective tissue cancer0InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0InformativeDirect
Disease Ontology (DO)lung carcinoma0InformativeDirect
Disease Ontology (DO)liver carcinoma0InformativeDirect
Disease Ontology (DO)viral infectious disease0InformativeDirect
Disease Ontology (DO)substance dependence0InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal tumor incidence0Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0InformativeDirect
Mammalian Phenotype (MP)abnormal cartilage morphology0InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0InformativeDirect
Mammalian Phenotype (MP)abnormal facial morphology0InformativeDirect
Mammalian Phenotype (MP)increased malignant tumor incidence0InformativeDirect
Mammalian Phenotype (MP)abnormal sex gland morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal total tissue mass0InformativeDirect
Mammalian Phenotype (MP)abnormal voluntary movement0InformativeDirect
Mammalian Phenotype (MP)premature death0InformativeDirect
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0InformativeDirect
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)hemorrhage0InformativeDirect
Mammalian Phenotype (MP)abnormal intestine morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0InformativeDirect
Mammalian Phenotype (MP)abnormal cranium morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal cell morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal induced cell death0InformativeDirect
Mammalian Phenotype (MP)decreased body weight0Highly InformativeDirect
Mammalian Phenotype (MP)increased sarcoma incidence0Highly InformativeDirect
Mammalian Phenotype (MP)decreased sensitivity to induced cell death0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell nucleus morphology0Highly InformativeDirect
Mammalian Phenotype (MP)premature aging0Highly InformativeDirect
Mammalian Phenotype (MP)increased T cell derived lymphoma incidence0Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis0Highly InformativeDirect
Mammalian Phenotype (MP)increased adenoma incidence0Highly InformativeDirect
Mammalian Phenotype (MP)increased adenocarcinoma incidence0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0Highly InformativeDirect
Mammalian Phenotype (MP)altered metastatic potential0Highly InformativeDirect
Mammalian Phenotype (MP)increased leukemia incidence0Highly InformativeDirect

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processCell cycle0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0.0000006112Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion0.000000000000003801Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.000000000001527Moderately InformativeDirect
DiseaseTumor suppressor0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.000000000008292Least InformativeDirect
Post-translational modificationAcetylation0.000004184Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationMethylation0.00000000000008561Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010991 SSF47719 Protein matches
Abstract

The p53 protein is a tetrameric transcription factor that plays a central role in the prevention of neoplastic transformation [PubMed7878469]. Oligomerization appears to be essential for the tumour suppressing activity of p53. p53 can be divided into different functional domains: an N-terminal transactivation domain, a proline-rich domain, a DNA-binding domain , a tetramerisation domain and a C-terminal regulatory region. The tetramerisation domain of human p53 extends from residues 325 to 356, and has a 4-helical bundle fold. The tetramerisation domain is essential for DNA binding, protein-protein interactions, post-translational modifications, and p53 degradation [PubMed11420672].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53 tetramerization domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the p53 tetramerization domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]