SUPERFAMILY 1.75 HMM library and genome assignments server


p53 tetramerization domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   p53 tetramerization domain [ 47718]
Superfamily:   p53 tetramerization domain [ 47719]
Families:   p53 tetramerization domain [ 47720]


Superfamily statistics
Genomes (77) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 311 405 6
Proteins 311 405 6


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1.938e-15 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.457e-13 Least Informative Direct
Biological Process (BP) single-organism cellular process 6.349e-09 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 5.102e-05 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.4813 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7745 Least Informative Inherited
Biological Process (BP) localization 0.005786 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) organ development 5.415e-13 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 7.65e-13 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 2.259e-11 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 4.49e-11 Moderately Informative Direct
Biological Process (BP) cell differentiation 3.855e-09 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0001552 Moderately Informative Direct
Biological Process (BP) immune system process 0.0001575 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0002631 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0003668 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0006226 Moderately Informative Direct
Biological Process (BP) organelle organization 0.005199 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001196 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.004228 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.0199 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.07535 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.005706 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1221 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.8766 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.001336 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1311 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01404 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.06147 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5551 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.355 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.2377 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.2505 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.2626 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.383 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.4954 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.00103 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.001827 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.04283 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01228 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.003978 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7987 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.009401 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.2158 Moderately Informative Inherited
Biological Process (BP) gene expression 0.5007 Moderately Informative Inherited
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0 Informative Direct
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 1.995e-13 Informative Direct
Biological Process (BP) regulation of growth 9.838e-13 Informative Direct
Biological Process (BP) mitochondrion organization 3.591e-10 Informative Direct
Biological Process (BP) generation of neurons 1.254e-09 Informative Direct
Biological Process (BP) transcription, DNA-dependent 2.522e-08 Informative Direct
Biological Process (BP) positive regulation of gene expression 7.276e-08 Informative Direct
Biological Process (BP) protein transport 1.46e-07 Informative Direct
Biological Process (BP) intracellular signal transduction 1.554e-07 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1.721e-07 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 4.564e-07 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1.552e-06 Informative Direct
Biological Process (BP) leukocyte activation 3.966e-06 Informative Direct
Biological Process (BP) central nervous system development 5.234e-06 Informative Direct
Biological Process (BP) immune effector process 7.362e-06 Informative Direct
Biological Process (BP) cellular membrane organization 7.413e-06 Informative Direct
Biological Process (BP) growth 9.847e-06 Informative Direct
Biological Process (BP) cell cycle process 1.561e-05 Informative Direct
Biological Process (BP) negative regulation of cell death 2.146e-05 Informative Direct
Biological Process (BP) regulation of body fluid levels 2.454e-05 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 2.826e-05 Informative Direct
Biological Process (BP) negative regulation of developmental process 9.14e-05 Informative Direct
Biological Process (BP) chromosome organization 0.0001039 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0001118 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0001613 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0001692 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0002294 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0005345 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.001842 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.04281 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.006176 Informative Inherited
Biological Process (BP) regulation of cell development 0.3208 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.04555 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.3103 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9232 Informative Inherited
Biological Process (BP) organ morphogenesis 0.8389 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.4077 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.135 Informative Inherited
Biological Process (BP) protein localization to organelle 0.003364 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.1158 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.385 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.00462 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01713 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.008173 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01091 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.01039 Informative Inherited
Biological Process (BP) response to light stimulus 0.167 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.01438 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.1784 Informative Inherited
Biological Process (BP) immune response 0.02199 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.02581 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.03427 Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0 Highly Informative Direct
Biological Process (BP) response to UV 0 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 3.755e-15 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 9.148e-15 Highly Informative Direct
Biological Process (BP) regulation of autophagy 1.435e-14 Highly Informative Direct
Biological Process (BP) B cell activation 2.458e-14 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 7.84e-14 Highly Informative Direct
Biological Process (BP) T cell differentiation 3.747e-13 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 6.111e-13 Highly Informative Direct
Biological Process (BP) mitochondrial transport 4.373e-12 Highly Informative Direct
Biological Process (BP) response to salt stress 1.226e-11 Highly Informative Direct
Biological Process (BP) response to drug 3.332e-11 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 1.317e-10 Highly Informative Direct
Biological Process (BP) nuclear import 5.861e-10 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 6.829e-10 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 2.172e-09 Highly Informative Direct
Biological Process (BP) protein import 7.247e-09 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 1.569e-08 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 3.833e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 1.796e-07 Highly Informative Direct
Biological Process (BP) cellular response to radiation 2.192e-07 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 3.882e-07 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 3.958e-07 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 4.149e-07 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 1.129e-06 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 1.442e-06 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 4.072e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 1.589e-05 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 2.713e-05 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0001054 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.0002376 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0003597 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.00042 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.009258 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.007203 Highly Informative Inherited
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.2434 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.003059 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.1168 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.05351 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.007951 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Molecular Function (MF) binding 1.562e-15 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 2.27e-06 Moderately Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) chromatin binding 2.243e-11 Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 1.107e-11 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 2.949e-07 Least Informative Direct
Cellular Component (CC) intracellular organelle part 3.142e-05 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.1219 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 2.383e-10 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.0001527 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.002092 Moderately Informative Inherited
Cellular Component (CC) mitochondrial matrix 0.0009266 Informative Direct
Cellular Component (CC) chromosome 0.0063 Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)immune system disease0Least InformativeDirect
Disease Ontology (DO)nervous system disease0Least InformativeDirect
Disease Ontology (DO)hematopoietic system disease0Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0Moderately InformativeDirect
Disease Ontology (DO)disease of mental health0Moderately InformativeDirect
Disease Ontology (DO)genetic disease0Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)autosomal dominant disease0InformativeDirect
Disease Ontology (DO)substance dependence0InformativeDirect
Disease Ontology (DO)lung carcinoma0InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0InformativeDirect
Disease Ontology (DO)gastrointestinal system cancer0InformativeDirect
Disease Ontology (DO)viral infectious disease0InformativeDirect
Disease Ontology (DO)connective tissue cancer0InformativeDirect
Disease Ontology (DO)endocrine gland cancer0InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0InformativeDirect
Disease Ontology (DO)liver carcinoma0Highly InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0Highly InformativeDirect
Disease Ontology (DO)melanoma0Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0Moderately InformativeDirect
Mammalian Phenotype (MP)tumorigenesis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0InformativeDirect
Mammalian Phenotype (MP)abnormal cartilage morphology0InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0InformativeDirect
Mammalian Phenotype (MP)abnormal facial morphology0InformativeDirect
Mammalian Phenotype (MP)increased malignant tumor incidence0InformativeDirect
Mammalian Phenotype (MP)abnormal sex gland morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal total tissue mass0InformativeDirect
Mammalian Phenotype (MP)abnormal voluntary movement0InformativeDirect
Mammalian Phenotype (MP)premature death0InformativeDirect
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0InformativeDirect
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)hemorrhage0InformativeDirect
Mammalian Phenotype (MP)abnormal female genitalia morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal intestine morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0InformativeDirect
Mammalian Phenotype (MP)abnormal cranium morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal cell morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal induced cell death0InformativeDirect
Mammalian Phenotype (MP)increased sarcoma incidence0Highly InformativeDirect
Mammalian Phenotype (MP)decreased sensitivity to induced cell death0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell nucleus morphology0Highly InformativeDirect
Mammalian Phenotype (MP)premature aging0Highly InformativeDirect
Mammalian Phenotype (MP)weight loss0Highly InformativeDirect
Mammalian Phenotype (MP)increased T cell derived lymphoma incidence0Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis0Highly InformativeDirect
Mammalian Phenotype (MP)increased integument system tumor incidence0Highly InformativeDirect
Mammalian Phenotype (MP)increased adenoma incidence0Highly InformativeDirect
Mammalian Phenotype (MP)increased adenocarcinoma incidence0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0Highly InformativeDirect
Mammalian Phenotype (MP)altered metastatic potential0Highly InformativeDirect
Mammalian Phenotype (MP)increased leukemia incidence0Highly InformativeDirect

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processCell cycle0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm6.009e-07Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion3.815e-15Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage1.539e-12Moderately InformativeDirect
DiseaseTumor suppressor0Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationPhosphoprotein8.302e-12Least InformativeDirect
Post-translational modificationAcetylation4.517e-06Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationMethylation7.98e-14Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010991 SSF47719 Protein matches
Abstract

The p53 protein is a tetrameric transcription factor that plays a central role in the prevention of neoplastic transformation [PubMed7878469]. Oligomerization appears to be essential for the tumour suppressing activity of p53. p53 can be divided into different functional domains: an N-terminal transactivation domain, a proline-rich domain, a DNA-binding domain , a tetramerisation domain and a C-terminal regulatory region. The tetramerisation domain of human p53 extends from residues 325 to 356, and has a 4-helical bundle fold. The tetramerisation domain is essential for DNA binding, protein-protein interactions, post-translational modifications, and p53 degradation [PubMed11420672].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53 tetramerization domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the p53 tetramerization domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]