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Anaphylotoxins (complement system) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Anaphylotoxins (complement system) [ 47685]
Superfamily:   Anaphylotoxins (complement system) [ 47686]
Families:   Anaphylotoxins (complement system) [ 47687]


Superfamily statistics
Genomes (72) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 377 471 3
Proteins 376 470 3


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.00000272 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0143 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.002098 Least Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.00000000000008605 Moderately Informative Direct
Biological Process (BP) immune system process 0.0000000002615 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.000000002193 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.00000259 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000007829 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.9327 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.1491 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4568 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.21 Moderately Informative Inherited
Biological Process (BP) regulation of defense response 0.000000000002899 Informative Direct
Biological Process (BP) immune response 0.00000000005463 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0.000000006025 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.000000006969 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.00000002572 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.00000003511 Informative Direct
Biological Process (BP) immune effector process 0.0000001166 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000002198 Informative Direct
Biological Process (BP) positive regulation of transport 0.000002771 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.00000429 Informative Direct
Biological Process (BP) regulation of immune response 0.000008258 Informative Direct
Biological Process (BP) defense response 0.00003796 Informative Direct
Biological Process (BP) regulation of immune effector process 0.00003868 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.2341 Informative Inherited
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) regulation of acute inflammatory response 0 Highly Informative Direct
Biological Process (BP) humoral immune response 0 Highly Informative Direct
Biological Process (BP) protein activation cascade 0 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 0.000000001164 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 0.000000001223 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.000000001646 Highly Informative Direct
Molecular Function (MF) binding 0.04216 Least Informative Inherited
Molecular Function (MF) receptor binding 0.0000000316 Informative Direct
Cellular Component (CC) extracellular region part 0.0000005271 Moderately Informative Direct
Cellular Component (CC) extracellular space 0.000000001856 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0Least InformativeDirect
Disease Ontology (DO)connective tissue disease0Moderately InformativeDirect
Disease Ontology (DO)mouth disease0.00001181Moderately InformativeDirect
Disease Ontology (DO)skin disease0.000449Moderately InformativeDirect
Disease Ontology (DO)lung disease0.0008932Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.001269Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.002323Moderately InformativeInherited
Disease Ontology (DO)periodontitis0.00000298InformativeDirect
Disease Ontology (DO)psoriasis0.00001209InformativeDirect
Disease Ontology (DO)asthma0.0001172InformativeDirect
Disease Ontology (DO)lupus erythematosus0.0001334InformativeDirect
Disease Ontology (DO)proteinuria0.0000002662Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Generalized abnormality of skin0Moderately InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0Moderately InformativeDirect
Mammalian Phenotype (MP)autoimmune response0InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0Highly InformativeDirect

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.0003543Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processFatty acid metabolism0.0000002193InformativeDirect
Biological processComplement pathway0Highly InformativeDirect
Biological processComplement alternate pathway0.000000000001327Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationToxin0.000000275InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0.0000007437Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationSulfation0.0000000006525InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000020 SSF47686 Protein matches
Abstract

Complement components C3, C4 and C5 are large glycoproteins that have important functions in the immune response and host defence [PubMed1431125]. They have a wide variety of biological activities and are proteolytically activated by cleavage at a specific site, forming a- and b-fragments [PubMed2777798]. A-fragments form distinct structural domains of approximately 76 amino acids, coded for by a single exon within the complement protein gene. The C3a, C4a and C5a components are referred to as anaphylatoxins [PubMed2777798, PubMed3081348]: they cause smooth muscle contraction, histamine release from mast cells, and enhanced vascular permeability [PubMed3081348]. They also mediate chemotaxis, inflammation, and generation of cytotoxic oxygen radicals [PubMed3081348]. The proteins are highly hydrophilic, with a mainly alpha-helical structure held together by 3 disulphide bridges [PubMed3081348].

Fibulins are secreted glycoproteins that become incorporated into a fibrillar extracellular matrix when expressed by cultured cells or added exogenously to cell monolayers [PubMed2269669, PubMed12778127]. The five known members of the family share an elongated structure and many calcium-binding sites, owing to the presence of tandem arrays of epidermal growth factor-like domains. They have overlapping binding sites for several basement-membrane proteins, tropoelastin, fibrillin, fibronectin and proteoglycans, and they participate in diverse supramolecular structures. The amino-terminal domain I of fibulin consists of three anaphylatoxin-like (AT) modules, each approximately 40 residues long and containing four or six cysteines. The structure of an AT module was determined for the complement-derived anaphylatoxin C3a, and was found to be a compact alpha-helical fold that is stabilized by three disulphide bridges in the pattern Cys14, Cys25 and Cys36 (where Cys is cysteine). The bulk of the remaining portion of the fibulin molecule is a series of nine EGF-like repeats [PubMed8245130]. The ProDom signature in this entry does not hit the fibulins.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Anaphylotoxins (complement system) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Anaphylotoxins (complement system) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]