SUPERFAMILY 1.75 HMM library and genome assignments server

Anaphylotoxins (complement system) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Anaphylotoxins (complement system) [ 47685]
Superfamily:   Anaphylotoxins (complement system) [ 47686]
Families:   Anaphylotoxins (complement system) [ 47687]


Superfamily statistics
Genomes (72) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 377 471 3
Proteins 376 470 3


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) positive regulation of biological process 0.0000000003062 Least Informative Direct
Biological Process (BP) protein metabolic process 0.000003175 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0003514 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.01928 Least Informative Inherited
Biological Process (BP) response to stimulus 0.002151 Least Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.0000000000005682 Moderately Informative Direct
Biological Process (BP) immune system process 0.0000000002564 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.000000003769 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.000006907 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000009454 Moderately Informative Direct
Biological Process (BP) defense response 0.00002641 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4555 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9866 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.1025 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5645 Moderately Informative Inherited
Biological Process (BP) regulation of response to wounding 0.000000000000003707 Informative Direct
Biological Process (BP) regulation of defense response 0.000000000003071 Informative Direct
Biological Process (BP) immune response 0.00000000005159 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.00000003712 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.00000004092 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00000006335 Informative Direct
Biological Process (BP) immune effector process 0.0000001196 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0000004502 Informative Direct
Biological Process (BP) positive regulation of transport 0.000002446 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000003137 Informative Direct
Biological Process (BP) regulation of immune response 0.000007771 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00001575 Informative Direct
Biological Process (BP) regulation of immune effector process 0.00004164 Informative Direct
Biological Process (BP) humoral immune response 0 Highly Informative Direct
Biological Process (BP) protein activation cascade 0 Highly Informative Direct
Biological Process (BP) regulation of acute inflammatory response 0 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 0.000000001004 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 0.000000001045 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.000000001817 Highly Informative Direct
Molecular Function (MF) binding 0.04515 Least Informative Inherited
Molecular Function (MF) receptor binding 0.00000003119 Informative Direct
Cellular Component (CC) extracellular region part 0.0000005404 Moderately Informative Direct
Cellular Component (CC) extracellular space 0.00000000188 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0Least InformativeDirect
Disease Ontology (DO)connective tissue disease0Moderately InformativeDirect
Disease Ontology (DO)mouth disease0.00001182Moderately InformativeDirect
Disease Ontology (DO)obstructive lung disease0.0003147Moderately InformativeDirect
Disease Ontology (DO)skin disease0.0004468Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.00127Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.002359Moderately InformativeInherited
Disease Ontology (DO)periodontitis0.000002975InformativeDirect
Disease Ontology (DO)psoriasis0.00001208InformativeDirect
Disease Ontology (DO)asthma0.0001178InformativeDirect
Disease Ontology (DO)lupus erythematosus0.0001342InformativeDirect
Disease Ontology (DO)proteinuria0.0000002665Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Generalized abnormality of skin0Moderately InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0Moderately InformativeDirect
Mammalian Phenotype (MP)autoimmune response0InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0Highly InformativeDirect

Document: MP annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antiinfectives for systemic use0Least InformativeDirect
Drugbank ATC_code (DB)immunoglobulins, normal human0InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.0003537Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processFatty acid metabolism0.000000217InformativeDirect
Biological processComplement pathway0Highly InformativeDirect
Biological processComplement alternate pathway0.00000000000133Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationToxin0.0000002749InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0.0000007706Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationSulfation0.0000000006636InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000020 SSF47686 Protein matches
Abstract

Complement components C3, C4 and C5 are large glycoproteins that have important functions in the immune response and host defence [PubMed1431125]. They have a wide variety of biological activities and are proteolytically activated by cleavage at a specific site, forming a- and b-fragments [PubMed2777798]. A-fragments form distinct structural domains of approximately 76 amino acids, coded for by a single exon within the complement protein gene. The C3a, C4a and C5a components are referred to as anaphylatoxins [PubMed2777798, PubMed3081348]: they cause smooth muscle contraction, histamine release from mast cells, and enhanced vascular permeability [PubMed3081348]. They also mediate chemotaxis, inflammation, and generation of cytotoxic oxygen radicals [PubMed3081348]. The proteins are highly hydrophilic, with a mainly alpha-helical structure held together by 3 disulphide bridges [PubMed3081348].

Fibulins are secreted glycoproteins that become incorporated into a fibrillar extracellular matrix when expressed by cultured cells or added exogenously to cell monolayers [PubMed2269669, PubMed12778127]. The five known members of the family share an elongated structure and many calcium-binding sites, owing to the presence of tandem arrays of epidermal growth factor-like domains. They have overlapping binding sites for several basement-membrane proteins, tropoelastin, fibrillin, fibronectin and proteoglycans, and they participate in diverse supramolecular structures. The amino-terminal domain I of fibulin consists of three anaphylatoxin-like (AT) modules, each approximately 40 residues long and containing four or six cysteines. The structure of an AT module was determined for the complement-derived anaphylatoxin C3a, and was found to be a compact alpha-helical fold that is stabilized by three disulphide bridges in the pattern Cys14, Cys25 and Cys36 (where Cys is cysteine). The bulk of the remaining portion of the fibulin molecule is a series of nine EGF-like repeats [PubMed8245130]. The ProDom signature in this entry does not hit the fibulins.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Anaphylotoxins (complement system) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Anaphylotoxins (complement system) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]