SUPERFAMILY 1.75 HMM library and genome assignments server

STAT superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   STAT-like [ 47654] (6)
Superfamily:   STAT [ 47655]
Families:   STAT [ 47656] (3)


Superfamily statistics
Genomes (162) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 706 960 3
Proteins 696 949 3


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.0000000002307 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000001698 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0000002449 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00001124 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0003441 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.009026 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.001658 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.3067 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.001255 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.03011 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.0085 Least Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) reproductive process 0 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000000000007248 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000000000000009016 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00000000000003411 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0000000000006378 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.000000000002317 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000000000006101 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000002577 Moderately Informative Direct
Biological Process (BP) gene expression 0.00000000002755 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00000000008547 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0000000002776 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0000000007 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00000005873 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0000001359 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000006821 Moderately Informative Direct
Biological Process (BP) defense response 0.0000007865 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00001642 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.04388 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.001321 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.3162 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7225 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.2674 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.8518 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.884 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.00833 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.8976 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.01622 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.7874 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8444 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.02404 Moderately Informative Inherited
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) response to nutrient levels 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) cell proliferation 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.000000000000003707 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000000000000007248 Informative Direct
Biological Process (BP) apoptotic process 0.00000000000001071 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00000000000001752 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000000000003576 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000000000001716 Informative Direct
Biological Process (BP) protein maturation 0.0000000000208 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.00000000007283 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0000000001313 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.0000000008168 Informative Direct
Biological Process (BP) regulation of growth 0.000000004999 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00000005039 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00000005069 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000000996 Informative Direct
Biological Process (BP) lipid localization 0.0000001497 Informative Direct
Biological Process (BP) regulation of cell activation 0.0000004064 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0000004683 Informative Direct
Biological Process (BP) response to bacterium 0.000001016 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000001079 Informative Direct
Biological Process (BP) generation of neurons 0.000001637 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.000001699 Informative Direct
Biological Process (BP) immune response 0.000002642 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.000003168 Informative Direct
Biological Process (BP) phosphorylation 0.000004378 Informative Direct
Biological Process (BP) gland development 0.00000571 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.000008336 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.00005174 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.00005257 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.00005728 Informative Direct
Biological Process (BP) regulation of response to wounding 0.0001017 Informative Direct
Biological Process (BP) sensory organ development 0.0002229 Informative Direct
Biological Process (BP) regulation of defense response 0.0003884 Informative Direct
Biological Process (BP) protein localization to organelle 0.0007239 Informative Direct
Biological Process (BP) positive regulation of cell death 0.0007877 Informative Direct
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.1254 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.05216 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.003538 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.4389 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.0503 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.005174 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1707 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.002092 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.3546 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.07442 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.01406 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.08076 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.00815 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02201 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.06562 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.008645 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.01172 Informative Inherited
Biological Process (BP) response to lipid 0.8966 Informative Inherited
Biological Process (BP) leukocyte activation 0.003714 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.8628 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.009481 Informative Inherited
Biological Process (BP) single organism reproductive process 0.02317 Informative Inherited
Biological Process (BP) reproductive structure development 0.04121 Informative Inherited
Biological Process (BP) protein transport 0.006342 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.8643 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.08613 Informative Inherited
Biological Process (BP) organ morphogenesis 0.003431 Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) zymogen activation 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0 Highly Informative Direct
Biological Process (BP) body fluid secretion 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.000000000000005526 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0000000000002105 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.0000000000004372 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.0000000000008216 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.000000000002542 Highly Informative Direct
Biological Process (BP) secretion by tissue 0.000000000005171 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.00000000001307 Highly Informative Direct
Biological Process (BP) kidney development 0.00000000006537 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00000000006758 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0000000001264 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000000001419 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.0000000001851 Highly Informative Direct
Biological Process (BP) positive regulation of response to wounding 0.0000000002028 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.000000001455 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte mediated immunity 0.000000002616 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.000000005378 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.000000008401 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00000001955 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.00000004657 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0000001413 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0000001642 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0000002095 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.0000003818 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000004565 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000009497 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.0000009608 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.000001041 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.000001166 Highly Informative Direct
Biological Process (BP) gonad development 0.000001193 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.00000452 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000007342 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000009001 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.00001673 Highly Informative Direct
Biological Process (BP) female pregnancy 0.00007476 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.0000762 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.000165 Highly Informative Direct
Biological Process (BP) innate immune response 0.0002005 Highly Informative Direct
Biological Process (BP) protein import 0.000256 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0008599 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.7347 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.003229 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.00471 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.01775 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.001758 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.2265 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.00408 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.001112 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.01698 Highly Informative Inherited
Biological Process (BP) stem cell development 0.005569 Highly Informative Inherited
Molecular Function (MF) binding 0.00000006084 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0000000000003029 Informative Direct
Molecular Function (MF) enzyme binding 0.000001294 Informative Direct
Molecular Function (MF) molecular transducer activity 0.000002599 Informative Direct
Molecular Function (MF) receptor binding 0.06899 Informative Inherited
Molecular Function (MF) protein phosphatase binding 0.0000000004106 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.000002525 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.00008598 Highly Informative Direct
Molecular Function (MF) kinase binding 0.03569 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.001023 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.9106 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0000000003506 Moderately Informative Direct
Cellular Component (CC) cytosol 0.0005632 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.2778 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.6549 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.001942 Informative Inherited
Cellular Component (CC) dendrite 0.000009444 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.04628Least InformativeInherited
Disease Ontology (DO)organ system cancer0.08676Least InformativeInherited
Disease Ontology (DO)obstructive lung disease0.00001501Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001737Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.01773Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7545Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000001373InformativeDirect
Disease Ontology (DO)glomerulonephritis0.0001088InformativeDirect
Disease Ontology (DO)myeloid leukemia0.135InformativeInherited
Disease Ontology (DO)viral infectious disease0.2717InformativeInherited
Disease Ontology (DO)mumps0.000000005262Highly InformativeDirect
Disease Ontology (DO)colitis0.0000001874Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome0.0000115Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.00001167Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.01516Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07681Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1089Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.000009695Moderately InformativeDirect
Mammalian Phenotype (MP)tumorigenesis0.0003461Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0005665Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008538Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.002536Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01363Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.03166Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.03587Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0368Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03793Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.03837Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2576Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.3101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3381Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin level0.000000007287InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.00000001245InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion0.0000002346InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.000007661InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0001714InformativeDirect
Mammalian Phenotype (MP)abnormal circulating leptin level0.0004218InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0004962InformativeDirect
Mammalian Phenotype (MP)abnormal antigen presentation0.0009244InformativeDirect
Mammalian Phenotype (MP)abnormal respiration0.0009703InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.001876InformativeInherited
Mammalian Phenotype (MP)abnormal female genitalia morphology0.002697InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.008275InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.008622InformativeInherited
Mammalian Phenotype (MP)abnormal cell proliferation0.02044InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05451InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.05562InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.06273InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1501InformativeInherited
Mammalian Phenotype (MP)abnormal total tissue mass0.1582InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2359InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology0.3039InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.4415InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.4539InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.6504InformativeInherited
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.0000001778Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0000003052Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion0.00000197Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.000002369Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.00000517Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.000006962Highly InformativeDirect
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.00001157Highly InformativeDirect
Mammalian Phenotype (MP)obese0.00002394Highly InformativeDirect
Mammalian Phenotype (MP)abnormal corpus luteum morphology0.00003776Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level0.00005598Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.0001204Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.0001566Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0003126Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor incidence0.0003536Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.00049Highly InformativeDirect
Mammalian Phenotype (MP)impaired glucose tolerance0.0007009Highly InformativeDirect
Mammalian Phenotype (MP)abnormal food intake0.002972Highly InformativeInherited
Mammalian Phenotype (MP)abnormal body fat mass0.003275Highly InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.0114Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus size0.04692Highly InformativeInherited
Mammalian Phenotype (MP)abnormal liver size0.08199Highly InformativeInherited

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0.0000000004354Least InformativeDirect
DomainSH2 domain0InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000003235Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00006234Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015988 SSF47655 Protein matches
Abstract

This entry represents a domain consisting of four long helices that forms a bundle with a left-handed twist (coiled coil), in a right-handed superhelix.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a STAT domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the STAT superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]