SUPERFAMILY 1.75 HMM library and genome assignments server


GST C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GST C-terminal domain-like [ 47615]
Superfamily:   GST C-terminal domain-like [ 47616] (2)
Families:   Glutathione S-transferase (GST), C-terminal domain [ 47617] (18)
  Arc1p N-terminal domain-like [ 158491]


Superfamily statistics
Genomes (1,797) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 25,592 44,387 104
Proteins 25,491 44,236 104


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups5.256e-070InformativeDirect
Molecular Function (MF)glutathione transferase activity6.233e-110Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.00092870.0002302Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0001147 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.06128 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 4.169e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.7524 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.001208 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.09208 Moderately Informative Inherited
Biological Process (BP) gene expression 0.3386 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) translation 3.445e-11 Informative Direct
Biological Process (BP) response to organic cyclic compound 5.295e-08 Informative Direct
Biological Process (BP) response to oxidative stress 5.352e-06 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.4509 Informative Inherited
Biological Process (BP) protein complex assembly 0.6985 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.7354 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.3596 Informative Inherited
Biological Process (BP) anion transport 0.01051 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.0103 Informative Inherited
Biological Process (BP) lipid catabolic process 0.05187 Informative Inherited
Biological Process (BP) protein localization to organelle 0.195 Informative Inherited
Biological Process (BP) mitochondrion organization 0.02506 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.4968 Informative Inherited
Biological Process (BP) protein transport 0.7373 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.009028 Informative Inherited
Biological Process (BP) xenobiotic metabolic process 0 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0 Highly Informative Direct
Biological Process (BP) establishment of protein localization to mitochondrion 2.912e-07 Highly Informative Direct
Biological Process (BP) inorganic anion transport 4.095e-05 Highly Informative Direct
Biological Process (BP) mitochondrial transport 9.243e-05 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.0002624 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.02692 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1526 Highly Informative Inherited
Biological Process (BP) lipid modification 0.01186 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 0.01523 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.01369 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.09314 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.2793 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.0008879 Informative Direct
Molecular Function (MF) protein dimerization activity 0.004974 Informative Inherited
Molecular Function (MF) RNA binding 0.3414 Informative Inherited
Molecular Function (MF) glutathione transferase activity 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 4.869e-05 Highly Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 5.332e-05 Highly Informative Direct
Molecular Function (MF) drug binding 7.827e-05 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.0168 Highly Informative Inherited
Molecular Function (MF) peroxidase activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0002302 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 1.647e-05 Moderately Informative Direct
Cellular Component (CC) organelle envelope 5.04e-05 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.06998 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.02861 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.8922 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.02197 Informative Inherited
Cellular Component (CC) nuclear membrane 0.0008792 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.6406Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors3.662e-08Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.3581Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Glutathione transferase0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases2.558e-15Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.2039Least InformativeInherited
Disease Ontology (DO)immune system disease0.6034Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1007Moderately InformativeInherited
Disease Ontology (DO)kidney disease0.109Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.2595Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.2659Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.4082Moderately InformativeInherited
Disease Ontology (DO)esophageal disease0.0002112InformativeDirect
Disease Ontology (DO)vasculitis0.008631InformativeInherited
Disease Ontology (DO)anemia0.01779InformativeInherited
Disease Ontology (DO)retinal disease0.0796InformativeInherited
Disease Ontology (DO)peptic esophagitis1.494e-06Highly InformativeDirect
Disease Ontology (DO)nephrotic syndrome0.000229Highly InformativeDirect
Disease Ontology (DO)vitiligo0.0003838Highly InformativeDirect
Disease Ontology (DO)degeneration of macula and posterior pole0.000406Highly InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant2.937e-08Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0003836Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.9124Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2189Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant3.137e-12InformativeDirect
Worm Phenotype (WP)metal response variant0.0003784InformativeDirect
Worm Phenotype (WP)cell stress response variant0.01053InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0Highly InformativeDirect
Worm Phenotype (WP)oxidative stress response variant0.0002748Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant1Least InformativeInherited
Plant ANatomical entity (PAN)vascular system0.002619InformativeInherited
Plant ANatomical entity (PAN)phloem0.0002207Highly InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000565InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0.5406Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors2.886e-08InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.3684InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0.9565InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases1.908e-15Highly InformativeDirect
Enzyme Commission (EC)Valine--tRNA ligase0.0004209Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.4632Least InformativeInherited
Biological processIon transport0.0001547Moderately InformativeDirect
Biological processProtein transport0.0002856Moderately InformativeDirect
Biological processLipid metabolism0.9506Moderately InformativeInherited
Biological processProtein biosynthesis1.166e-15InformativeDirect
Biological processStress response2.319e-10InformativeDirect
Biological processFatty acid metabolism0.04721InformativeInherited
Biological processDetoxification0Highly InformativeDirect
Biological processPhenylalanine catabolism0Highly InformativeDirect
Biological processProstaglandin biosynthesis2.772e-15Highly InformativeDirect
Biological processNitrate assimilation7.313e-15Highly InformativeDirect
Cellular componentCytoplasm4.892e-10Least InformativeDirect
Cellular componentMitochondrion1.888e-08Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationElongation factor0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationEye lens protein1.762e-15Highly InformativeDirect
Post-translational modificationPeroxidase3.02e-07Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein4.966e-06Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0006859Least InformativeDirect
UniPathway (UP)biopolymer biosynthesis4.711e-05Moderately InformativeDirect
UniPathway (UP)protein biosynthesis1.608e-06InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR010987 SSF47616 Protein matches
Abstract

In eukaryotes, glutathione S-transferases (GSTs) participate in the detoxification of reactive electrophilic compounds by catalysing their conjugation to glutathione. GST is found as a domain in S-crystallins from squid, and proteins with no known GST activity, such as eukaryotic elongation factors 1-gamma and the HSP26 family of stress-related proteins, which include auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. The major lens polypeptide of cephalopods is also a GST [PubMed9074797]. Bacterial GSTs of known function often have a specific, growth-supporting role in biodegradative metabolism: epoxide ring opening and tetrachlorohydroquinone reductive dehalogenation are two examples of the reactions catalysed by these bacterial GSTs. Some regulatory proteins, like the stringent starvation proteins, also belong to the GST family [PubMed9045797]. GST seems to be absent from Archaea in which gamma-glutamylcysteine substitute to glutathione as major thiol.

Glutathione S-transferases form homodimers, but in eukaryotes can also form heterodimers of the A1 and A2 or YC1 and YC2 subunits. The homodimeric enzymes display a conserved structural fold. Each monomer is composed of a distinct N-terminal sub-domain, which adopts the thioredoxin fold, and a C-terminal all-helical sub-domain, which adopts a 4-helical bundle fold. This entry is the C-terminal domain.

Glutaredoxin 2 (Grx2), glutathione-dependent disulphide oxidoreductases, is structurally similar to GSTs, even though they lack any sequence similarity. Grx2 is also composed of N and C terminal subdomains. It is thought that the primary function of Grx2 is to catalyse reversible glutathionylation of proteins with glutathione in cellular redox regulation including the response to oxidative stress. Grx2 is dissimilar to other glutaredoxins apart from containing the conserved active site residues [PubMed14713336].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 52 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GST C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 52 hidden Markov models representing the GST C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]