SUPERFAMILY 1.75 HMM library and genome assignments server

Domain of poly(ADP-ribose) polymerase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Domain of poly(ADP-ribose) polymerase [ 47586]
Superfamily:   Domain of poly(ADP-ribose) polymerase [ 47587]
Families:   Domain of poly(ADP-ribose) polymerase [ 47588]


Superfamily statistics
Genomes (355) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 977 1,101 5
Proteins 969 1,096 5


Functional annotation
General category Information
Detailed category Transcription

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000000000612 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000000007195 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00000000003976 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.00000000006682 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0000000002588 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000000002591 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0003376 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.002069 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.5093 Least Informative Inherited
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00007027 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.0001012 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0005326 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.002277 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1097 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.03753 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.008961 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.08012 Moderately Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0 Informative Direct
Biological Process (BP) DNA repair 0 Informative Direct
Biological Process (BP) chromosome organization 0.0000000000001668 Informative Direct
Biological Process (BP) regulation of growth 0.00000256 Informative Direct
Biological Process (BP) response to inorganic substance 0.0001748 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0004355 Informative Direct
Biological Process (BP) response to oxidative stress 0.00166 Informative Inherited
Biological Process (BP) response to superoxide 0 Highly Informative Direct
Biological Process (BP) protein glycosylation 0.0000000003062 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0000004922 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.00003897 Highly Informative Direct
Molecular Function (MF) transferase activity 0.009625 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.000000001239 Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.00000000000001212 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.00000009414 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00001556 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.9194 Least Informative Inherited
Cellular Component (CC) nuclear part 0.02412 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.02794 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.1412 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.2119Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.0009377Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal response to radiation0.0000001472InformativeDirect
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.000373InformativeDirect
Mammalian Phenotype (MP)increased mortality induced by ionizing radiation0.0000001229Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0.0000002216Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainRepeat0.00000002106Least InformativeDirect
DomainZinc-finger0.00000000001714Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionZinc0.0000004651Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationADP-ribosylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR004102 SSF47587 Protein matches
Abstract

Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The regulatory domain of the polymerase is almost always associated with the C-terminal catalytic domain (see ).

This domain consists of a duplication of two helix-loop-helix structural repeats [PubMed9521710].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Domain of poly(ADP-ribose) polymerase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Domain of poly(ADP-ribose) polymerase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]