SUPERFAMILY 1.75 HMM library and genome assignments server


EF-hand superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   EF Hand-like [ 47472] (4)
Superfamily:   EF-hand [ 47473] (11)
Families:   Calbindin D9K [ 47474]
  S100 proteins [ 47478]
  Polcalcin [ 89048] (3)
  Osteonectin [ 47489]
  Parvalbumin [ 47492] (2)
  Calmodulin-like [ 47502] (23)
  Eps15 homology domain (EH domain) [ 47543] (3)
  Cbp40 (plasmodial specific CaII-binding protein LAV1-2) [ 81758]
  Penta-EF-hand proteins [ 63550] (6)
  EF-hand modules in multidomain proteins [ 47547] (8)
  p25-alpha [ 140538] (2)


Superfamily statistics
Genomes (1,135) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 67,240 81,218 217
Proteins 59,403 72,530 215


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process1.003e-138.655e-14Least InformativeDirect
Biological Process (BP)developmental process5.799e-078.253e-10Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus1.613e-110Least InformativeDirect
Biological Process (BP)localization1.235e-080Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis05.062e-11Least InformativeDirect
Biological Process (BP)regulation of cellular process0.090930.0004578Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)system process9.215e-062.228e-05Moderately InformativeDirect
Biological Process (BP)signal transduction0.00035682.835e-07Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity1.03e-090Moderately InformativeDirect
Biological Process (BP)regulation of programmed cell death0.00014361Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.87350.174Moderately InformativeInherited
Biological Process (BP)response to organic substance0.92121Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.035850.6965Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.19980.005874Moderately InformativeInherited
Biological Process (BP)organelle organization8.174e-070.006485Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.00073840.1846Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.43360.007354Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.19331Moderately InformativeInherited
Biological Process (BP)tissue development0.02170.02496Moderately InformativeInherited
Biological Process (BP)cellular localization0.012530Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function1.898e-050.04526Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.042021Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0011041Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.019021Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.11830.001343Moderately InformativeInherited
Biological Process (BP)homeostatic process0.42571.61e-06Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.97440.04397Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.87521Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process16.026e-07Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.0042340.02126Moderately InformativeInherited
Biological Process (BP)ion transport10.05303Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0017680.3061Moderately InformativeInherited
Biological Process (BP)organic substance transport0.94121Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0017551.318e-08Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.48550.005524Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.050510.08704Moderately InformativeInherited
Biological Process (BP)cell differentiation0.05740.3608Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.13970.006088Moderately InformativeInherited
Biological Process (BP)nervous system development0.90140.7129Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.04070.000178Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.78871Moderately InformativeInherited
Biological Process (BP)multi-organism process0.30530.4965Moderately InformativeInherited
Biological Process (BP)immune system process2.76e-080.05991Moderately InformativeInherited
Biological Process (BP)muscle system process5.405e-090InformativeDirect
Biological Process (BP)cellular component movement4.171e-056.82e-10InformativeDirect
Biological Process (BP)cytoskeleton organization00InformativeDirect
Biological Process (BP)microtubule-based process4.011e-093.468e-14InformativeDirect
Biological Process (BP)response to wounding1.114e-072.833e-07InformativeDirect
Biological Process (BP)protein transport5.326e-072.149e-06InformativeDirect
Biological Process (BP)cellular membrane organization1.499e-067.948e-10InformativeDirect
Biological Process (BP)metal ion transport0.00075092.225e-06InformativeDirect
Biological Process (BP)actin filament-based process00InformativeDirect
Biological Process (BP)regulation of response to external stimulus1.732e-085.593e-08InformativeDirect
Biological Process (BP)regulation of intracellular transport0.00063635.947e-06InformativeDirect
Biological Process (BP)cellular component morphogenesis3.504e-063.449e-05InformativeDirect
Biological Process (BP)intracellular signal transduction2.514e-050.000558InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00025341.194e-12InformativeDirect
Biological Process (BP)positive regulation of transport0.00096477.004e-06InformativeDirect
Biological Process (BP)muscle tissue development9.867e-088.547e-09InformativeDirect
Biological Process (BP)muscle structure development3.505e-100InformativeDirect
Biological Process (BP)organelle assembly0.00047991.805e-09InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process5.006e-073.365e-05InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway0.05240.9439InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.26811InformativeInherited
Biological Process (BP)regulation of ion transport0.0019252.19e-10InformativeInherited
Biological Process (BP)positive regulation of immune system process0.23370.6389InformativeInherited
Biological Process (BP)regulation of cellular component movement2.37e-050.02639InformativeInherited
Biological Process (BP)regulation of locomotion5.803e-050.02785InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.39070.766InformativeInherited
Biological Process (BP)regulation of cell cycle process0.0025160.2516InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.70280.002675InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.023940.09163InformativeInherited
Biological Process (BP)regulation of peptidase activity0.23760.09368InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.2640.7902InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.042760.1369InformativeInherited
Biological Process (BP)positive regulation of cell proliferation0.00046580.4443InformativeInherited
Biological Process (BP)transmembrane transport10.9775InformativeInherited
Biological Process (BP)biological adhesion4.608e-050.9152InformativeInherited
Biological Process (BP)blood circulation2.101e-130.7363InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.550.5497InformativeInherited
Biological Process (BP)organelle localization0.10370.003916InformativeInherited
Biological Process (BP)response to inorganic substance0.012935.427e-08InformativeInherited
Biological Process (BP)protein complex assembly0.88370.07557InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly0.030051InformativeInherited
Biological Process (BP)vesicle-mediated transport0.025910.1038InformativeInherited
Biological Process (BP)immune effector process10.8003InformativeInherited
Biological Process (BP)secretion by cell0.11980.0005351InformativeInherited
Biological Process (BP)cell projection organization0.0016860.9238InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.019151.292e-05InformativeInherited
Biological Process (BP)regulation of organelle organization0.65950.3492InformativeInherited
Biological Process (BP)positive regulation of developmental process0.31453.821e-07InformativeInherited
Biological Process (BP)locomotion2.723e-060.002579InformativeInherited
Biological Process (BP)localization of cell0.013181InformativeInherited
Biological Process (BP)generation of neurons0.025720.2858InformativeInherited
Biological Process (BP)regulation of nervous system development0.21380.1465InformativeInherited
Biological Process (BP)regulation of cell development0.40542.408e-06InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.094891InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.35451InformativeInherited
Biological Process (BP)immune response0.0054460.3598InformativeInherited
Biological Process (BP)defense response0.012840.0008854InformativeInherited
Biological Process (BP)response to other organism0.22240.01281InformativeInherited
Biological Process (BP)response to light stimulus0.0042490.07252InformativeInherited
Biological Process (BP)leukocyte activation0.83450.8811InformativeInherited
Biological Process (BP)myeloid leukocyte activation9.882e-050.0002775Highly InformativeDirect
Biological Process (BP)detection of light stimulus1.47e-071.39e-08Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis1.006e-091.091e-14Highly InformativeDirect
Biological Process (BP)regulation of neuron projection development0.00010172.798e-10Highly InformativeDirect
Biological Process (BP)actin filament-based movement1.962e-079.306e-13Highly InformativeDirect
Biological Process (BP)actomyosin structure organization2.669e-061.114e-08Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.00080444.503e-08Highly InformativeDirect
Biological Process (BP)positive regulation of response to external stimulus3.76e-130.0001035Highly InformativeDirect
Biological Process (BP)positive regulation of intracellular transport1.154e-056.004e-07Highly InformativeDirect
Biological Process (BP)regulation of transporter activity4.877e-070Highly InformativeDirect
Biological Process (BP)regulation of mononuclear cell proliferation1.598e-080.0007321Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transport6.321e-061.091e-14Highly InformativeDirect
Biological Process (BP)negative regulation of protein complex disassembly0.00052960Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation2.645e-060.0001767Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling2.598e-060.0007556Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation6.09e-054.536e-11Highly InformativeDirect
Biological Process (BP)protein polymerization2.473e-102.372e-09Highly InformativeDirect
Biological Process (BP)response to calcium ion8.221e-110Highly InformativeDirect
Biological Process (BP)regulation of protein kinase B signaling cascade6.954e-050.0007754Highly InformativeDirect
Biological Process (BP)heart contraction0.00061013.165e-09Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation0.00012050.0007128Highly InformativeDirect
Biological Process (BP)regulation of protein depolymerization0.00082450Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle7.369e-111.172e-09Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway8.584e-077.836e-05Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.00076610.1134Highly InformativeInherited
Biological Process (BP)regulation of lymphocyte migration0.01730.004333Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration3.321e-150.001466Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.56940.9939Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process0.00010780.02868Highly InformativeInherited
Biological Process (BP)positive regulation of endopeptidase activity1.335e-090.4361Highly InformativeInherited
Biological Process (BP)cell projection assembly0.00039110.1551Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport1.306e-060.06693Highly InformativeInherited
Biological Process (BP)calcium ion transport0.41720.0004786Highly InformativeInherited
Biological Process (BP)ion transmembrane transport0.015990.1753Highly InformativeInherited
Biological Process (BP)cell adhesion0.01241Highly InformativeInherited
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.17580.0006433Highly InformativeInherited
Biological Process (BP)actin filament organization0.00057030.2159Highly InformativeInherited
Biological Process (BP)regulation of behavior1.589e-060.07683Highly InformativeInherited
Biological Process (BP)leukocyte mediated immunity0.57720.1771Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.12620.0001908Highly InformativeInherited
Biological Process (BP)exocytosis0.25630.3017Highly InformativeInherited
Biological Process (BP)cell fate commitment0.0050220.09489Highly InformativeInherited
Biological Process (BP)regulation of T cell activation1.598e-080.02146Highly InformativeInherited
Biological Process (BP)regulation of proton transport7.615e-060.001233Highly InformativeInherited
Biological Process (BP)regulation of cyclic nucleotide metabolic process1.229e-070.001658Highly InformativeInherited
Biological Process (BP)regulation of myeloid cell differentiation0.0013910.4732Highly InformativeInherited
Biological Process (BP)regulation of leukocyte differentiation0.12421Highly InformativeInherited
Biological Process (BP)chemotaxis0.019220.4299Highly InformativeInherited
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.060720.003718Highly InformativeInherited
Biological Process (BP)small GTPase mediated signal transduction0.11640.0003654Highly InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway0.30470.8797Highly InformativeInherited
Biological Process (BP)cellular response to radiation0.035280.3471Highly InformativeInherited
Biological Process (BP)innate immune response0.011790.8393Highly InformativeInherited
Biological Process (BP)regulation of microtubule polymerization or depolymerization0.39429.637e-08Highly InformativeInherited
Biological Process (BP)negative regulation of cytoskeleton organization0.08184.897e-08Highly InformativeInherited
Biological Process (BP)phagocytosis0.0016971Highly InformativeInherited
Biological Process (BP)leukocyte migration0.00068940.04085Highly InformativeInherited
Biological Process (BP)inflammatory response1.315e-090.001025Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity10.02147Least InformativeInherited
Molecular Function (MF)enzyme regulator activity8.896e-090Moderately InformativeDirect
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides0.92641Moderately InformativeInherited
Molecular Function (MF)transporter activity10.2433Moderately InformativeInherited
Molecular Function (MF)structural molecule activity0.0011472.8e-12Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds10.05616Moderately InformativeInherited
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)inorganic cation transmembrane transporter activity0.45890.1872InformativeInherited
Molecular Function (MF)receptor binding0.2681InformativeInherited
Molecular Function (MF)nucleoside-triphosphatase activity0.75661InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.037635.839e-05InformativeInherited
Molecular Function (MF)enzyme activator activity6.396e-050.8082InformativeInherited
Molecular Function (MF)phosphoric ester hydrolase activity0.9815.315e-11InformativeInherited
Molecular Function (MF)cation channel activity0.00049266.868e-08Highly InformativeDirect
Molecular Function (MF)calcium ion binding00Highly InformativeDirect
Molecular Function (MF)calcium ion transmembrane transporter activity3.376e-051.114e-09Highly InformativeDirect
Molecular Function (MF)phosphatase regulator activity1.513e-050.0001858Highly InformativeDirect
Molecular Function (MF)protein complex binding0.0016460.1974Highly InformativeInherited
Molecular Function (MF)phosphoprotein phosphatase activity0.060910.1311Highly InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)protein complex03.582e-12Least InformativeDirect
Cellular Component (CC)intracellular organelle part2.09e-050.01401Least InformativeInherited
Cellular Component (CC)cytoplasmic part10Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)membrane0.011070Least InformativeInherited
Cellular Component (CC)cytoskeleton00Moderately InformativeDirect
Cellular Component (CC)cell projection00Moderately InformativeDirect
Cellular Component (CC)endoplasmic reticulum0.0053142.919e-08Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.035230Moderately InformativeInherited
Cellular Component (CC)actin cytoskeleton3.02e-063.128e-15InformativeDirect
Cellular Component (CC)cell leading edge00InformativeDirect
Cellular Component (CC)contractile fiber part00InformativeDirect
Cellular Component (CC)lytic vacuole0.95381InformativeInherited
Cellular Component (CC)microtubule cytoskeleton11InformativeInherited
Cellular Component (CC)protein serine/threonine phosphatase complex2.468e-057.478e-05Highly InformativeDirect
Cellular Component (CC)sarcoplasmic reticulum0.00091936.545e-07Highly InformativeDirect
Cellular Component (CC)cell division site part0.00036835.933e-05Highly InformativeDirect
Cellular Component (CC)cilium part0.00020020.0001417Highly InformativeDirect
Cellular Component (CC)lysosome0.53150.9745Highly InformativeInherited
Cellular Component (CC)centrosome1.345e-060.0017Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)