SUPERFAMILY 1.75 HMM library and genome assignments server


EF-hand superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   EF Hand-like [ 47472] (4)
Superfamily:   EF-hand [ 47473] (11)
Families:   Calbindin D9K [ 47474]
  S100 proteins [ 47478]
  Polcalcin [ 89048] (3)
  Osteonectin [ 47489]
  Parvalbumin [ 47492] (2)
  Calmodulin-like [ 47502] (23)
  Eps15 homology domain (EH domain) [ 47543] (3)
  Cbp40 (plasmodial specific CaII-binding protein LAV1-2) [ 81758]
  Penta-EF-hand proteins [ 63550] (6)
  EF-hand modules in multidomain proteins [ 47547] (8)
  p25-alpha [ 140538] (2)


Superfamily statistics
Genomes (1,124) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 64,080 0 217
Proteins 56,610 0 215


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process4.32e-135.046e-14Least InformativeDirect
Biological Process (BP)developmental process9.104e-073.491e-10Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus2.035e-110Least InformativeDirect
Biological Process (BP)localization1.269e-080Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis07.557e-11Least InformativeDirect
Biological Process (BP)regulation of cellular process0.12550.0002907Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)system process5.06e-061.806e-05Moderately InformativeDirect
Biological Process (BP)signal transduction0.00035732.07e-07Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity8.523e-100Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.83480.1203Moderately InformativeInherited
Biological Process (BP)response to organic substance0.90121Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.035140.6794Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.23840.004245Moderately InformativeInherited
Biological Process (BP)organelle organization6.391e-070.003258Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.00075190.1643Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.43950.006939Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.19491Moderately InformativeInherited
Biological Process (BP)tissue development0.016140.02911Moderately InformativeInherited
Biological Process (BP)reproduction0.0080321Moderately InformativeInherited
Biological Process (BP)organ development0.021661Moderately InformativeInherited
Biological Process (BP)cellular localization0.011620Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function1.208e-050.02639Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.038241Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00085621Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.015121Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.12190.0004659Moderately InformativeInherited
Biological Process (BP)homeostatic process0.3271.155e-07Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.90810.7085Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.99670.08544Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.90121Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process12.718e-07Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.0047790.02184Moderately InformativeInherited
Biological Process (BP)ion transport10.07371Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0015290.2982Moderately InformativeInherited
Biological Process (BP)organic substance transport0.94771Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0019282.263e-08Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.50540.007594Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.057020.07544Moderately InformativeInherited
Biological Process (BP)cell differentiation0.054630.3489Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.15820.006764Moderately InformativeInherited
Biological Process (BP)nervous system development0.87610.6049Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.047490.0001061Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.82031Moderately InformativeInherited
Biological Process (BP)multi-organism process0.26320.4275Moderately InformativeInherited
Biological Process (BP)immune system process2.755e-080.05178Moderately InformativeInherited
Biological Process (BP)muscle system process5.187e-090InformativeDirect
Biological Process (BP)cellular component movement4.623e-052.252e-10InformativeDirect
Biological Process (BP)cytoskeleton organization00InformativeDirect
Biological Process (BP)microtubule-based process3.715e-091.922e-15InformativeDirect
Biological Process (BP)response to wounding7.941e-071.013e-06InformativeDirect
Biological Process (BP)protein transport5.468e-072.214e-06InformativeDirect
Biological Process (BP)cellular membrane organization1.045e-065.348e-10InformativeDirect
Biological Process (BP)metal ion transport0.00076072.356e-06InformativeDirect
Biological Process (BP)actin filament-based process00InformativeDirect
Biological Process (BP)regulation of response to external stimulus1.927e-086.494e-08InformativeDirect
Biological Process (BP)regulation of intracellular transport0.00062684.772e-06InformativeDirect
Biological Process (BP)cellular component morphogenesis2.571e-067.057e-06InformativeDirect
Biological Process (BP)intracellular signal transduction2.572e-050.0007109InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00017836.747e-13InformativeDirect
Biological Process (BP)positive regulation of transport0.00097075.59e-06InformativeDirect
Biological Process (BP)muscle tissue development5.629e-085.686e-09InformativeDirect
Biological Process (BP)muscle structure development1.56e-100InformativeDirect
Biological Process (BP)organelle assembly0.00071761.084e-09InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process1.044e-071.276e-05InformativeDirect
Biological Process (BP)regulation of apoptotic process0.81941InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.24151InformativeInherited
Biological Process (BP)regulation of ion transport0.0020461.591e-10InformativeInherited
Biological Process (BP)positive regulation of immune system process0.25070.6378InformativeInherited
Biological Process (BP)regulation of cellular component movement2.496e-050.03932InformativeInherited
Biological Process (BP)regulation of locomotion6.67e-050.04006InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.43480.8645InformativeInherited
Biological Process (BP)regulation of cell cycle process0.0023120.2394InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.740.003288InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.022220.07943InformativeInherited
Biological Process (BP)regulation of peptidase activity0.22670.09872InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.30480.8119InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.04130.1233InformativeInherited
Biological Process (BP)regulation of cell proliferation0.018011InformativeInherited
Biological Process (BP)transmembrane transport11InformativeInherited
Biological Process (BP)biological adhesion0.00071941InformativeInherited
Biological Process (BP)blood circulation1.91e-130.7346InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.22271InformativeInherited
Biological Process (BP)response to nutrient levels0.75140.798InformativeInherited
Biological Process (BP)reproductive system development0.77531InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.51550.5129InformativeInherited
Biological Process (BP)organelle localization0.10040.004265InformativeInherited
Biological Process (BP)response to inorganic substance0.014056.051e-08InformativeInherited
Biological Process (BP)protein complex assembly0.94220.1092InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly0.017561InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.0016761InformativeInherited
Biological Process (BP)vesicle-mediated transport0.026270.1135InformativeInherited
Biological Process (BP)immune effector process10.8036InformativeInherited
Biological Process (BP)secretion by cell0.11280.0005354InformativeInherited
Biological Process (BP)cell projection organization0.0014640.8085InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.018990.0001014InformativeInherited
Biological Process (BP)regulation of organelle organization0.65120.2342InformativeInherited
Biological Process (BP)positive regulation of developmental process0.33355.705e-07InformativeInherited
Biological Process (BP)locomotion2.709e-060.002253InformativeInherited
Biological Process (BP)localization of cell0.015031InformativeInherited
Biological Process (BP)generation of neurons0.025080.2718InformativeInherited
Biological Process (BP)regulation of nervous system development0.21370.1382InformativeInherited
Biological Process (BP)regulation of cell development0.41222.561e-06InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.097831InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.40161InformativeInherited
Biological Process (BP)immune response0.0053170.3481InformativeInherited
Biological Process (BP)defense response0.007140.0005493InformativeInherited
Biological Process (BP)response to other organism0.22330.00926InformativeInherited
Biological Process (BP)response to light stimulus0.0042910.06722InformativeInherited
Biological Process (BP)leukocyte activation0.79030.841InformativeInherited
Biological Process (BP)myeloid leukocyte activation9.969e-050.0002663Highly InformativeDirect
Biological Process (BP)inflammatory response3.187e-100.0008392Highly InformativeDirect
Biological Process (BP)detection of light stimulus1.51e-071.547e-08Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis7.512e-107.281e-15Highly InformativeDirect
Biological Process (BP)regulation of neuron projection development9.725e-051.474e-10Highly InformativeDirect
Biological Process (BP)actin filament-based movement1.93e-071.344e-12Highly InformativeDirect
Biological Process (BP)regulation of cyclic nucleotide metabolic process4.519e-080.0009089Highly InformativeDirect
Biological Process (BP)actomyosin structure organization2.335e-065.143e-09Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.0008455.856e-09Highly InformativeDirect
Biological Process (BP)positive regulation of response to external stimulus4.944e-130.0001172Highly InformativeDirect
Biological Process (BP)positive regulation of intracellular transport1.237e-054.533e-07Highly InformativeDirect
Biological Process (BP)regulation of transporter activity5.004e-070Highly InformativeDirect
Biological Process (BP)regulation of mononuclear cell proliferation1.619e-080.0007236Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transport6.81e-061.077e-14Highly InformativeDirect
Biological Process (BP)negative regulation of protein complex disassembly0.00054230Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation2.778e-060.00016Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling2.875e-060.0007133Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation6.653e-055.044e-11Highly InformativeDirect
Biological Process (BP)protein polymerization2.474e-101.528e-09Highly InformativeDirect
Biological Process (BP)response to calcium ion8.524e-110Highly InformativeDirect
Biological Process (BP)regulation of protein kinase B signaling cascade8.643e-050.0009885Highly InformativeDirect
Biological Process (BP)heart contraction0.00054432.76e-09Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation0.00012340.0007871Highly InformativeDirect
Biological Process (BP)regulation of protein depolymerization0.000830Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle6.29e-118.259e-10Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway8.688e-075.924e-05Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.00078350.1168Highly InformativeInherited
Biological Process (BP)regulation of lymphocyte migration0.017320.004489Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration3.3e-150.002293Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.56180.98Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process9.905e-050.02619Highly InformativeInherited
Biological Process (BP)positive regulation of peptidase activity4.232e-070.236Highly InformativeInherited
Biological Process (BP)regulation of cysteine-type endopeptidase activity7.033e-081Highly InformativeInherited
Biological Process (BP)cell projection assembly0.00044850.1516Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport1.38e-060.07535Highly InformativeInherited
Biological Process (BP)plasma membrane organization0.00710.04804Highly InformativeInherited
Biological Process (BP)calcium ion transport0.41750.000493Highly InformativeInherited
Biological Process (BP)ion transmembrane transport0.013970.1969Highly InformativeInherited
Biological Process (BP)cell adhesion0.056191Highly InformativeInherited
Biological Process (BP)fruiting body development0.00017460.004387Highly InformativeInherited
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.18790.0007613Highly InformativeInherited
Biological Process (BP)actin filament organization0.00057870.2307Highly InformativeInherited
Biological Process (BP)regulation of protein stability9.484e-050.336Highly InformativeInherited
Biological Process (BP)regulation of behavior1.825e-060.08308Highly InformativeInherited
Biological Process (BP)leukocyte mediated immunity0.57790.1824Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.12630.0001594Highly InformativeInherited
Biological Process (BP)exocytosis0.25260.3028Highly InformativeInherited
Biological Process (BP)cell fate commitment0.0053220.1146Highly InformativeInherited
Biological Process (BP)regulation of T cell activation1.619e-080.02165Highly InformativeInherited
Biological Process (BP)regulation of proton transport8.122e-060.001437Highly InformativeInherited
Biological Process (BP)regulation of myeloid cell differentiation0.001470.4845Highly InformativeInherited
Biological Process (BP)positive regulation of cell differentiation0.053230.001423Highly InformativeInherited
Biological Process (BP)regulation of leukocyte differentiation0.12741Highly InformativeInherited
Biological Process (BP)chemotaxis0.0210.4478Highly InformativeInherited
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.06330.003813Highly InformativeInherited
Biological Process (BP)small GTPase mediated signal transduction0.12010.0004097Highly InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway0.30110.911Highly InformativeInherited
Biological Process (BP)cellular response to radiation0.036920.3497Highly InformativeInherited
Biological Process (BP)innate immune response0.012970.8335Highly InformativeInherited
Biological Process (BP)regulation of microtubule polymerization or depolymerization0.39433.533e-08Highly InformativeInherited
Biological Process (BP)negative regulation of cytoskeleton organization0.084182.14e-07Highly InformativeInherited
Biological Process (BP)phagocytosis0.0015721Highly InformativeInherited
Biological Process (BP)leukocyte migration0.00068680.04104Highly InformativeInherited
Biological Process (BP)microtubule cytoskeleton organization0.040240.3217Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity10.01871Least InformativeInherited
Molecular Function (MF)enzyme regulator activity8.332e-090Moderately InformativeDirect
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)transporter activity10.2369Moderately InformativeInherited
Molecular Function (MF)structural molecule activity0.0011331.988e-12Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds10.05595Moderately InformativeInherited
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)inorganic cation transmembrane transporter activity0.4560.1881InformativeInherited
Molecular Function (MF)receptor binding0.26921InformativeInherited
Molecular Function (MF)nucleoside-triphosphatase activity0.75741InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.03795.93e-05InformativeInherited
Molecular Function (MF)enzyme activator activity6.356e-050.8006InformativeInherited
Molecular Function (MF)phosphoric ester hydrolase activity0.97984.97e-11InformativeInherited
Molecular Function (MF)cation channel activity0.00049476.165e-08Highly InformativeDirect
Molecular Function (MF)calcium ion binding00Highly InformativeDirect
Molecular Function (MF)calcium ion transmembrane transporter activity3.386e-051.151e-09Highly InformativeDirect
Molecular Function (MF)phosphatase regulator activity1.573e-050.0001933Highly InformativeDirect
Molecular Function (MF)protein complex binding0.0043340.2599Highly InformativeInherited
Molecular Function (MF)phosphoprotein phosphatase activity0.06120.1278Highly InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)protein complex02.437e-12Least InformativeDirect
Cellular Component (CC)intracellular organelle part3.316e-050.02254Least InformativeInherited
Cellular Component (CC)cytoplasmic part10Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)membrane0.0024290Least InformativeInherited
Cellular Component (CC)cytoskeleton00Moderately InformativeDirect
Cellular Component (CC)cell projection00Moderately InformativeDirect
Cellular Component (CC)endoplasmic reticulum0.0043341.312e-08Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.0085610Moderately InformativeInherited
Cellular Component (CC)actin cytoskeleton2.16e-060InformativeDirect
Cellular Component (CC)cell leading edge00InformativeDirect
Cellular Component (CC)contractile fiber part00InformativeDirect
Cellular Component (CC)lytic vacuole0.94771InformativeInherited
Cellular Component (CC)microtubule cytoskeleton11InformativeInherited
Cellular Component (CC)ruffle5.554e-141.476e-09Highly InformativeDirect
Cellular Component (CC)actin filament5.733e-153.036e-13Highly InformativeDirect
Cellular Component (CC)protein serine/threonine phosphatase complex2.822e-057.734e-05Highly InformativeDirect
Cellular Component (CC)myosin complex00Highly InformativeDirect
Cellular Component (CC)sarcoplasmic reticulum0.00021211.715e-07Highly InformativeDirect
Cellular Component (CC)leading edge membrane2.964e-080.0009968Highly InformativeDirect
Cellular Component (CC)nonmotile primary cilium3.393e-097.997e-06Highly InformativeDirect
Cellular Component (CC)cell division site part0.0004126.421e-05Highly InformativeDirect
Cellular Component (CC)cilium part0.00065370.0003611Highly InformativeDirect
Cellular Component (CC)microtubule organizing center part05.643e-09Highly InformativeDirect
Cellular Component (CC)contractile ring0.00019730.0006215Highly InformativeDirect
Cellular Component (CC)lysosome0.52790.9758Highly InformativeInherited
Cellular Component (CC)centrosome3.22e-060.003264Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)