SUPERFAMILY 1.75 HMM library and genome assignments server

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EF-hand superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   EF Hand-like [ 47472] (4)
Superfamily:   EF-hand [ 47473] (11)
Families:   Calbindin D9K [ 47474]
  S100 proteins [ 47478]
  Polcalcin [ 89048] (3)
  Osteonectin [ 47489]
  Parvalbumin [ 47492] (2)
  Calmodulin-like [ 47502] (23)
  Eps15 homology domain (EH domain) [ 47543] (3)
  Cbp40 (plasmodial specific CaII-binding protein LAV1-2) [ 81758]
  Penta-EF-hand proteins [ 63550] (6)
  EF-hand modules in multidomain proteins [ 47547] (8)
  p25-alpha [ 140538] (2)


Superfamily statistics
Genomes (1,135) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 67,240 81,218 217
Proteins 59,403 72,530 215


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00000000000014270.00000000000002119Least InformativeDirect
Biological Process (BP)developmental process0.00000076890.0000000002014Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus0.00000000020390Least InformativeDirect
Biological Process (BP)localization0.000000080240Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00.0000000001167Least InformativeDirect
Biological Process (BP)regulation of cellular process0.14140.0007192Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)system process0.000010750.00004701Moderately InformativeDirect
Biological Process (BP)signal transduction0.00017360.0000001724Moderately InformativeDirect
Biological Process (BP)regulation of localization0.00066270.000000007025Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.0000000048420Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.85060.1729Moderately InformativeInherited
Biological Process (BP)response to organic substance0.8531Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.025440.6448Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.31140.01084Moderately InformativeInherited
Biological Process (BP)organelle organization0.00000046710.005007Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.0019550.2605Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.44150.008442Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.28661Moderately InformativeInherited
Biological Process (BP)ion transport10.05577Moderately InformativeInherited
Biological Process (BP)tissue development0.021310.03334Moderately InformativeInherited
Biological Process (BP)cellular localization0.010730Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.000017480.03796Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.54211Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.055131Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0010361Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.00032271Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.130.001758Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.11430.000000006265Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.98310.05985Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.86991Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.000001208Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.0081830.02753Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0013880.3084Moderately InformativeInherited
Biological Process (BP)organic substance transport0.90791Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.51240.00534Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.050740.06639Moderately InformativeInherited
Biological Process (BP)cell differentiation0.046830.3314Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.14820.003585Moderately InformativeInherited
Biological Process (BP)nervous system development0.91010.8721Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.042210.00004345Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.82521Moderately InformativeInherited
Biological Process (BP)multi-organism process0.27970.5734Moderately InformativeInherited
Biological Process (BP)immune system process0.000000087920.08076Moderately InformativeInherited
Biological Process (BP)muscle system process0.0000000046410InformativeDirect
Biological Process (BP)cellular component movement0.000065530.0000000006566InformativeDirect
Biological Process (BP)cytoskeleton organization00InformativeDirect
Biological Process (BP)microtubule-based process0.0000000024470.00000000000001435InformativeDirect
Biological Process (BP)response to wounding0.00000032230.0000004737InformativeDirect
Biological Process (BP)protein transport0.00000068560.000002607InformativeDirect
Biological Process (BP)cellular membrane organization0.0000010070.0000000007329InformativeDirect
Biological Process (BP)actin filament-based process00InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.000000046280.0000001153InformativeDirect
Biological Process (BP)cellular component morphogenesis0.000004380.00005035InformativeDirect
Biological Process (BP)intracellular signal transduction0.000017480.0002162InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0003010.000000000004569InformativeDirect
Biological Process (BP)positive regulation of transport0.00023290.000001553InformativeDirect
Biological Process (BP)muscle tissue development0.00000013460.00000001369InformativeDirect
Biological Process (BP)muscle structure development0.00000000043510InformativeDirect
Biological Process (BP)organelle assembly0.0005850.00000000226InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.00000028270.00003318InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway0.11651InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.32581InformativeInherited
Biological Process (BP)regulation of ion transport0.0050390.000000000666InformativeInherited
Biological Process (BP)positive regulation of immune system process0.23050.6165InformativeInherited
Biological Process (BP)regulation of cellular component movement0.000024780.02474InformativeInherited
Biological Process (BP)regulation of locomotion0.000059350.02673InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.39830.7934InformativeInherited
Biological Process (BP)regulation of cell cycle process0.0026540.2682InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.72090.003279InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.024730.1004InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.25750.7785InformativeInherited
Biological Process (BP)regulation of peptidase activity0.33870.1278InformativeInherited
Biological Process (BP)regulation of protein localization0.351InformativeInherited
Biological Process (BP)regulation of intracellular transport0.0019950.00001087InformativeInherited
Biological Process (BP)cell wall organization or biogenesis0.47450.9096InformativeInherited
Biological Process (BP)regulation of cell proliferation0.013860.9542InformativeInherited
Biological Process (BP)metal ion transport0.002550.000003397InformativeInherited
Biological Process (BP)transmembrane transport11InformativeInherited
Biological Process (BP)biological adhesion0.00026030.9907InformativeInherited
Biological Process (BP)blood circulation0.00000000000022610.7587InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.49820.5792InformativeInherited
Biological Process (BP)organelle localization0.10730.003308InformativeInherited
Biological Process (BP)response to inorganic substance0.0094580.00000002753InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly0.013041InformativeInherited
Biological Process (BP)vesicle-mediated transport0.019840.09645InformativeInherited
Biological Process (BP)immune effector process10.7667InformativeInherited
Biological Process (BP)secretion by cell0.11270.0005601InformativeInherited
Biological Process (BP)regulation of cell activation0.0025860.00003671InformativeInherited
Biological Process (BP)cell projection organization0.0016030.897InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.020730.00001319InformativeInherited
Biological Process (BP)regulation of organelle organization0.62090.2698InformativeInherited
Biological Process (BP)positive regulation of developmental process0.31560.0000003678InformativeInherited
Biological Process (BP)locomotion0.00000890.004101InformativeInherited
Biological Process (BP)localization of cell0.021021InformativeInherited
Biological Process (BP)generation of neurons0.025590.293InformativeInherited
Biological Process (BP)regulation of nervous system development0.20920.1551InformativeInherited
Biological Process (BP)regulation of cell development0.44720.000003006InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.096231InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.36361InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.015310.00002857InformativeInherited
Biological Process (BP)immune response0.0037730.3167InformativeInherited
Biological Process (BP)defense response0.022970.001144InformativeInherited
Biological Process (BP)response to light stimulus0.0045850.07904InformativeInherited
Biological Process (BP)leukocyte activation0.80980.8625InformativeInherited
Biological Process (BP)myeloid leukocyte activation0.00010130.0003012Highly InformativeDirect
Biological Process (BP)detection of light stimulus0.00000013890.00000001268Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis0.0000000016670.00000000000004286Highly InformativeDirect
Biological Process (BP)regulation of neuron projection development0.00011120.00000001836Highly InformativeDirect
Biological Process (BP)actin filament-based movement0.00000016250.0000000000007707Highly InformativeDirect
Biological Process (BP)actomyosin structure organization0.0000023150.000000009908Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.00089760.00000004069Highly InformativeDirect
Biological Process (BP)positive regulation of response to external stimulus0.0000000000034860.0005191Highly InformativeDirect
Biological Process (BP)positive regulation of intracellular transport0.000056480.0000009947Highly InformativeDirect
Biological Process (BP)regulation of transporter activity0.00000051530Highly InformativeDirect
Biological Process (BP)regulation of mononuclear cell proliferation0.000000016710.0007645Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transport0.0000054180.00000000000001435Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation0.0000025550.0001685Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling0.0000023590.0007263Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation0.000038710.0000000000271Highly InformativeDirect
Biological Process (BP)protein polymerization0.00000000023280.00000000223Highly InformativeDirect
Biological Process (BP)response to calcium ion0.000000000056320Highly InformativeDirect
Biological Process (BP)regulation of protein kinase B signaling cascade0.000099790.0008232Highly InformativeDirect
Biological Process (BP)heart contraction0.00060970.000000004383Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation0.00011770.0007064Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle0.000000000076950.000000001279Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway0.00001530.0006391Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.0037260.2024Highly InformativeInherited
Biological Process (BP)regulation of lymphocyte migration0.010420.003877Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration0.0000000000000079780.001482Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.58851Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process0.000077310.02485Highly InformativeInherited
Biological Process (BP)regulation of protein complex disassembly0.04330.00000000008349Highly InformativeInherited
Biological Process (BP)positive regulation of endopeptidase activity0.000000012640.5091Highly InformativeInherited
Biological Process (BP)cell projection assembly0.00048370.1692Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport0.0000013540.06113Highly InformativeInherited
Biological Process (BP)external encapsulating structure organization0.035510.06981Highly InformativeInherited
Biological Process (BP)calcium ion transport0.44660.0004811Highly InformativeInherited
Biological Process (BP)cell adhesion0.028891Highly InformativeInherited
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.180.0005761Highly InformativeInherited
Biological Process (BP)actin filament organization0.00062270.2049Highly InformativeInherited
Biological Process (BP)regulation of behavior0.0000013160.08349Highly InformativeInherited
Biological Process (BP)leukocyte mediated immunity0.57720.1846Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.12640.0001949Highly InformativeInherited
Biological Process (BP)exocytosis0.26460.3202Highly InformativeInherited
Biological Process (BP)cell fate commitment0.0048750.08244Highly InformativeInherited
Biological Process (BP)regulation of T cell activation0.000000020370.01923Highly InformativeInherited
Biological Process (BP)regulation of proton transport0.0000060830.001036Highly InformativeInherited
Biological Process (BP)regulation of cyclic nucleotide metabolic process0.00000023360.002268Highly InformativeInherited
Biological Process (BP)regulation of myeloid cell differentiation0.0011690.4698Highly InformativeInherited
Biological Process (BP)regulation of leukocyte differentiation0.11461Highly InformativeInherited
Biological Process (BP)chemotaxis0.030140.4544Highly InformativeInherited
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.056370.004072Highly InformativeInherited
Biological Process (BP)small GTPase mediated signal transduction0.12080.0004772Highly InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway0.33050.8836Highly InformativeInherited
Biological Process (BP)cellular response to radiation0.034880.351Highly InformativeInherited
Biological Process (BP)innate immune response0.0062920.7785Highly InformativeInherited
Biological Process (BP)regulation of microtubule polymerization or depolymerization0.37430.00000006553Highly InformativeInherited
Biological Process (BP)negative regulation of cytoskeleton organization0.083190.00000003244Highly InformativeInherited
Biological Process (BP)phagocytosis0.0015581Highly InformativeInherited
Biological Process (BP)leukocyte migration0.002020.07758Highly InformativeInherited
Biological Process (BP)inflammatory response0.000000004330.001973Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity10.02726Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.000000010860Moderately InformativeDirect
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)transporter activity10.2391Moderately InformativeInherited
Molecular Function (MF)structural molecule activity0.0011910.000000000003087Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds10.06412Moderately InformativeInherited
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)inorganic cation transmembrane transporter activity0.46470.1902InformativeInherited
Molecular Function (MF)receptor binding0.26591InformativeInherited
Molecular Function (MF)nucleoside-triphosphatase activity0.76651InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.039150.00006115InformativeInherited
Molecular Function (MF)enzyme activator activity0.000068910.8283InformativeInherited
Molecular Function (MF)phosphoric ester hydrolase activity0.99390.0000000001202InformativeInherited
Molecular Function (MF)cation channel activity0.00050120.00000007208Highly InformativeDirect
Molecular Function (MF)calcium ion binding00Highly InformativeDirect
Molecular Function (MF)calcium ion transmembrane transporter activity0.000034320.000000001076Highly InformativeDirect
Molecular Function (MF)phosphatase regulator activity0.000026040.0002245Highly InformativeDirect
Molecular Function (MF)protein complex binding0.0014920.2012Highly InformativeInherited
Molecular Function (MF)phosphoprotein phosphatase activity0.065690.1352Highly InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)protein complex00.000000000004067Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.000022250.0185Least InformativeInherited
Cellular Component (CC)cytoplasmic part10Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)membrane0.014360Least InformativeInherited
Cellular Component (CC)cytoskeleton00Moderately InformativeDirect
Cellular Component (CC)cell projection00Moderately InformativeDirect
Cellular Component (CC)endoplasmic reticulum0.0055940.00000003026Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.034380Moderately InformativeInherited
Cellular Component (CC)actin cytoskeleton0.0000032970.000000000000001589InformativeDirect
Cellular Component (CC)cell leading edge00InformativeDirect
Cellular Component (CC)contractile fiber part00InformativeDirect
Cellular Component (CC)lytic vacuole0.95341InformativeInherited
Cellular Component (CC)microtubule cytoskeleton11InformativeInherited
Cellular Component (CC)protein serine/threonine phosphatase complex0.000024670.00008336Highly InformativeDirect
Cellular Component (CC)sarcoplasmic reticulum0.00088850.0000008104Highly InformativeDirect
Cellular Component (CC)cell division site part0.00036740.00006772Highly InformativeDirect
Cellular Component (CC)cilium part0.00024410.0001882Highly InformativeDirect
Cellular Component (CC)lysosome0.53670.04326Highly InformativeInherited
Cellular Component (CC)centrosome0.0000014040.002276Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)