SUPERFAMILY 1.75 HMM library and genome assignments server

EF-hand superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   EF Hand-like [ 47472] (4)
Superfamily:   EF-hand [ 47473] (11)
Families:   Calbindin D9K [ 47474]
  S100 proteins [ 47478]
  Polcalcin [ 89048] (3)
  Osteonectin [ 47489]
  Parvalbumin [ 47492] (2)
  Calmodulin-like [ 47502] (23)
  Eps15 homology domain (EH domain) [ 47543] (3)
  Cbp40 (plasmodial specific CaII-binding protein LAV1-2) [ 81758]
  Penta-EF-hand proteins [ 63550] (6)
  EF-hand modules in multidomain proteins [ 47547] (8)
  p25-alpha [ 140538] (2)


Superfamily statistics
Genomes (1,136) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 68,733 81,218 217
Proteins 60,750 72,530 215


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00000000000038480.0000000000004052Least InformativeDirect
Biological Process (BP)developmental process0.000003240.000000001043Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000045850.000000006278Least InformativeDirect
Biological Process (BP)response to stimulus0.00000000019420Least InformativeDirect
Biological Process (BP)localization0.00000033390Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00.000000000000007248Least InformativeDirect
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.0071610.9769Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process0.260.0006879Least InformativeInherited
Biological Process (BP)signal transduction0.000088380.0000002207Moderately InformativeDirect
Biological Process (BP)regulation of localization0.00076860.00000001697Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.0000000065670Moderately InformativeDirect
Biological Process (BP)regulation of phosphorus metabolic process0.0000058180.00003068Moderately InformativeDirect
Biological Process (BP)cellular localization0.0008010Moderately InformativeDirect
Biological Process (BP)single-organism organelle organization00Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.86470.1779Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.0090450.02749Moderately InformativeInherited
Biological Process (BP)response to organic substance0.88181Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.0015190.8107Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.000019430.04911Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.55840.002421Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.17340.006862Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.64580.1096Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.026950.4874Moderately InformativeInherited
Biological Process (BP)organic substance transport0.84981Moderately InformativeInherited
Biological Process (BP)ion transport10.3587Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.49020.01318Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.32290.763Moderately InformativeInherited
Biological Process (BP)tissue development0.18070.7875Moderately InformativeInherited
Biological Process (BP)gene expression0.59821Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0059551Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.088470.00000000143Moderately InformativeInherited
Biological Process (BP)cell differentiation0.051590.3788Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0018870.8388Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.94461Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.008510.02878Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.14020.002477Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.0077941Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.025461Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.026240.00001729Moderately InformativeInherited
Biological Process (BP)nervous system development0.85260.6809Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.75531Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0013970.3173Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.056130.6771Moderately InformativeInherited
Biological Process (BP)immune system process0.000000085370.08135Moderately InformativeInherited
Biological Process (BP)defense response0.020330.09243Moderately InformativeInherited
Biological Process (BP)multi-organism process0.080470.4368Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.018570.004286Moderately InformativeInherited
Biological Process (BP)muscle system process0.00000003520InformativeDirect
Biological Process (BP)cellular component movement0.000000045070.000000000000001913InformativeDirect
Biological Process (BP)cytoskeleton organization00InformativeDirect
Biological Process (BP)microtubule-based process0.0000000000004620InformativeDirect
Biological Process (BP)actin filament-based process00InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.00000035960.00003588InformativeDirect
Biological Process (BP)cellular component morphogenesis0.0000052110.00008822InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00019080.0000000000002226InformativeDirect
Biological Process (BP)protein maturation0.0000000030820.0002603InformativeDirect
Biological Process (BP)muscle structure development0.0000000009090InformativeDirect
Biological Process (BP)organelle assembly0.0002210.00000000007378InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.0000004750.00002825InformativeDirect
Biological Process (BP)regulation of cellular component movement0.000018460.02517InformativeInherited
Biological Process (BP)regulation of cell cycle process0.0025260.08382InformativeInherited
Biological Process (BP)localization of cell0.018691InformativeInherited
Biological Process (BP)positive regulation of gene expression0.00002261InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.04750.1485InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.27840.8169InformativeInherited
Biological Process (BP)regulation of peptidase activity0.098060.5205InformativeInherited
Biological Process (BP)cell projection organization0.000052290.3342InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.20570.1578InformativeInherited
Biological Process (BP)regulation of protein localization0.34591InformativeInherited
Biological Process (BP)regulation of system process0.008620.4282InformativeInherited
Biological Process (BP)single-organism cellular localization0.0025290.0003057InformativeInherited
Biological Process (BP)single-organism membrane organization0.001120InformativeInherited
Biological Process (BP)protein transport0.0000028540.001688InformativeInherited
Biological Process (BP)cell wall organization or biogenesis0.1040.4239InformativeInherited
Biological Process (BP)positive regulation of intracellular signal transduction0.0027450.7815InformativeInherited
Biological Process (BP)biological adhesion0.00022040.9581InformativeInherited
Biological Process (BP)organelle localization0.013390.00128InformativeInherited
Biological Process (BP)blood circulation0.00000000000030960.7608InformativeInherited
Biological Process (BP)response to inorganic substance0.009970.00000002992InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly0.0060221InformativeInherited
Biological Process (BP)regulation of cell proliferation0.011390.955InformativeInherited
Biological Process (BP)regulation of cell activation0.0021070.0000372InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.0098450.00004767InformativeInherited
Biological Process (BP)immune response0.0037370.3108InformativeInherited
Biological Process (BP)single-organism intracellular transport0.014250InformativeInherited
Biological Process (BP)secretion by cell0.017890.0000253InformativeInherited
Biological Process (BP)positive regulation of transport0.0018980.00002413InformativeInherited
Biological Process (BP)regulation of ion transport0.0048970.000000001152InformativeInherited
Biological Process (BP)regulation of intracellular transport0.0019430.000009227InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.34210.00000004681InformativeInherited
Biological Process (BP)regulation of organelle organization0.54520.235InformativeInherited
Biological Process (BP)positive regulation of developmental process0.63510.00002975InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.9170.7091InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.057430.06939InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.0015741InformativeInherited
Biological Process (BP)intracellular signal transduction0.000042690.002026InformativeInherited
Biological Process (BP)response to light stimulus0.0044330.07974InformativeInherited
Biological Process (BP)generation of neurons0.026280.2997InformativeInherited
Biological Process (BP)regulation of nervous system development0.21780.08849InformativeInherited
Biological Process (BP)regulation of cell development0.39820.0008304InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.831InformativeInherited
Biological Process (BP)defense response to other organism0.73310.6566InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.58620.004907InformativeInherited
Biological Process (BP)vesicle-mediated transport0.01170.05167InformativeInherited
Biological Process (BP)positive regulation of immune system process0.093730.6064InformativeInherited
Biological Process (BP)regulation of locomotion0.000053840.02682InformativeInherited
Biological Process (BP)locomotion0.00001060.004237InformativeInherited
Biological Process (BP)immune effector process10.7723InformativeInherited
Biological Process (BP)leukocyte activation0.81060.8576InformativeInherited
Biological Process (BP)myeloid leukocyte activation0.00010020.0003053Highly InformativeDirect
Biological Process (BP)inflammatory response0.0000000035860.00001374Highly InformativeDirect
Biological Process (BP)detection of light stimulus0.000000077750.00000001095Highly InformativeDirect
Biological Process (BP)regulation of proton transport0.0000051820.000765Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis0.0000000017810Highly InformativeDirect
Biological Process (BP)regulation of neuron projection development0.00012270.0000000203Highly InformativeDirect
Biological Process (BP)actin filament-based movement0.00000014360.0000000000006878Highly InformativeDirect
Biological Process (BP)actomyosin structure organization0.0000023050.000000005689Highly InformativeDirect
Biological Process (BP)positive regulation of intracellular transport0.00021980.000004029Highly InformativeDirect
Biological Process (BP)positive regulation of transporter activity0.000001040.000000000009528Highly InformativeDirect
Biological Process (BP)regulation of mononuclear cell proliferation0.000000016530.0008362Highly InformativeDirect
Biological Process (BP)positive regulation of transmembrane transport0.00000087620.000000000001117Highly InformativeDirect
Biological Process (BP)regulation of ion transmembrane transport0.000044150.00002132Highly InformativeDirect
Biological Process (BP)positive regulation of mitotic cell cycle0.00000002280.000216Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation0.0000019780.0001578Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling0.000013220.0005981Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation0.00023640.0000000008338Highly InformativeDirect
Biological Process (BP)protein polymerization0.00000000005010.000000000001362Highly InformativeDirect
Biological Process (BP)response to calcium ion0.000000000055960Highly InformativeDirect
Biological Process (BP)heart contraction0.00047180.000000004065Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation0.00010250.0006448Highly InformativeDirect
Biological Process (BP)regulation of muscle system process0.00030690.00009838Highly InformativeDirect
Biological Process (BP)response to nerve growth factor0.000026240.00002248Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle0.000000000075940.0000000005315Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte migration0.010360.003345Highly InformativeInherited
Biological Process (BP)leukocyte migration0.0019360.07684Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.61821Highly InformativeInherited
Biological Process (BP)positive regulation of ion transport0.010060.000001208Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process0.00071410.00918Highly InformativeInherited
Biological Process (BP)regulation of protein complex disassembly0.039880.00000000007126Highly InformativeInherited
Biological Process (BP)regulation of protein localization to nucleus0.0000080750.005818Highly InformativeInherited
Biological Process (BP)positive regulation of endopeptidase activity0.000000012520.5107Highly InformativeInherited
Biological Process (BP)zymogen activation0.000000012520.03702Highly InformativeInherited
Biological Process (BP)cell projection assembly0.0007830.2192Highly InformativeInherited
Biological Process (BP)regulation of protein targeting0.0000000000012240.02429Highly InformativeInherited
Biological Process (BP)positive regulation of behavior0.000000039310.007377Highly InformativeInherited
Biological Process (BP)plasma membrane organization0.0000045510.01299Highly InformativeInherited
Biological Process (BP)positive regulation of response to external stimulus0.000000000038790.001565Highly InformativeInherited
Biological Process (BP)external encapsulating structure organization0.0032810.008151Highly InformativeInherited
Biological Process (BP)cell adhesion0.00012520.9656Highly InformativeInherited
Biological Process (BP)actin filament organization0.00037810.1352Highly InformativeInherited
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.0085390.00000002178Highly InformativeInherited
Biological Process (BP)regulation of myeloid cell differentiation0.0011420.3319Highly InformativeInherited
Biological Process (BP)regulation of hematopoietic progenitor cell differentiation0.000013820.004128Highly InformativeInherited
Biological Process (BP)leukocyte mediated immunity0.5780.1905Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.12640.000191Highly InformativeInherited
Biological Process (BP)exocytosis0.26260.3231Highly InformativeInherited
Biological Process (BP)cell fate commitment0.0037060.06226Highly InformativeInherited
Biological Process (BP)regulation of T cell activation0.000000020120.01924Highly InformativeInherited
Biological Process (BP)regulation of transmembrane transporter activity0.0011340.0000006381Highly InformativeInherited
Biological Process (BP)regulation of leukocyte differentiation0.11371Highly InformativeInherited
Biological Process (BP)positive regulation of cyclic nucleotide metabolic process0.00000081130.001319Highly InformativeInherited
Biological Process (BP)chemotaxis0.030610.451Highly InformativeInherited
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.052110.0041Highly InformativeInherited
Biological Process (BP)small GTPase mediated signal transduction0.09540.000126Highly InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway0.33180.889Highly InformativeInherited
Biological Process (BP)cellular response to radiation0.041370.4077Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration0.0000000000000079360.001386Highly InformativeInherited
Biological Process (BP)innate immune response0.0072150.1609Highly InformativeInherited
Biological Process (BP)regulation of microtubule polymerization or depolymerization0.28650.000000038Highly InformativeInherited
Biological Process (BP)negative regulation of cytoskeleton organization0.11970.0000000477Highly InformativeInherited
Biological Process (BP)phagocytosis0.0010611Highly InformativeInherited
Biological Process (BP)protein localization to membrane0.0015490.0000006898Highly InformativeInherited
Biological Process (BP)regulation of chemotaxis0.000076030.05345Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity10.0275Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.00000000080870Moderately InformativeDirect
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)transporter activity10.2409Moderately InformativeInherited
Molecular Function (MF)structural molecule activity0.001190.0000000000029Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds10.07611Moderately InformativeInherited
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)protein complex binding00InformativeDirect
Molecular Function (MF)receptor binding0.27031InformativeInherited
Molecular Function (MF)nucleoside-triphosphatase activity0.76521InformativeInherited
Molecular Function (MF)enzyme activator activity0.000511InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.03920.00002211InformativeInherited
Molecular Function (MF)phosphatase activity0.92821InformativeInherited
Molecular Function (MF)cation channel activity0.00050330.00000007437Highly InformativeDirect
Molecular Function (MF)calcium ion binding00Highly InformativeDirect
Molecular Function (MF)calcium ion transmembrane transporter activity0.000034510.0000000008941Highly InformativeDirect
Molecular Function (MF)phosphatase regulator activity0.000069690.0007921Highly InformativeDirect
Molecular Function (MF)actin filament binding0.00019540.00000000008084Highly InformativeDirect
Molecular Function (MF)phosphoprotein phosphatase activity0.065830.14Highly InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)protein complex0.000000000000002780.0000000001808Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.000012840.0001023Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.97790Least InformativeInherited
Cellular Component (CC)membrane0.015560Least InformativeInherited
Cellular Component (CC)cytoskeleton00Moderately InformativeDirect
Cellular Component (CC)cell projection00Moderately InformativeDirect
Cellular Component (CC)endoplasmic reticulum0.0050310.00000003923Moderately InformativeInherited
Cellular Component (CC)plasma membrane part0.00170.000007212Moderately InformativeInherited
Cellular Component (CC)actin cytoskeleton0.0000017370InformativeDirect
Cellular Component (CC)cell leading edge00InformativeDirect
Cellular Component (CC)contractile fiber part00InformativeDirect
Cellular Component (CC)synapse0.00057920InformativeDirect
Cellular Component (CC)microtubule cytoskeleton11InformativeInherited
Cellular Component (CC)lytic vacuole0.95691InformativeInherited
Cellular Component (CC)protein serine/threonine phosphatase complex0.000024740.00008226Highly InformativeDirect
Cellular Component (CC)sarcoplasmic reticulum0.0008820.0000007806Highly InformativeDirect
Cellular Component (CC)cell division site part0.00036820.00006302Highly InformativeDirect
Cellular Component (CC)sarcolemma0.00093960Highly InformativeDirect
Cellular Component (CC)microtubule organizing center0.069011Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)