SUPERFAMILY 1.75 HMM library and genome assignments server

HLH, helix-loop-helix DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HLH-like [ 47458] (2)
Superfamily:   HLH, helix-loop-helix DNA-binding domain [ 47459]
Families:   HLH, helix-loop-helix DNA-binding domain [ 47460] (8)


Superfamily statistics
Genomes (458) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,877 24,850 13
Proteins 25,808 24,800 13


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process0.000000000000036160Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00000000000090950Least InformativeDirect
Biological Process (BP)response to stimulus0.0000096070Least InformativeDirect
Biological Process (BP)regulation of cellular process0.91310Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.099670Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.32960.0000000000217Least InformativeInherited
Biological Process (BP)single-organism cellular process0.26320.07612Least InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.000000000000012480Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process0.000000000000064930Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00000000000019030Moderately InformativeDirect
Biological Process (BP)regulation of gene expression0.0000000000040660Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.000000012270.000000000006163Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.0000018850.000007118Moderately InformativeDirect
Biological Process (BP)cellular response to stress0.0093580.03542Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.020420Moderately InformativeInherited
Biological Process (BP)cell differentiation0.71840.0002309Moderately InformativeInherited
Biological Process (BP)tissue development0.19360.0000000000001894Moderately InformativeInherited
Biological Process (BP)nervous system development0.000060010.1688Moderately InformativeInherited
Biological Process (BP)organ development0.20410.000000000007497Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.099780.9868Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.58221Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.00074570.03614Moderately InformativeInherited
Biological Process (BP)response to organic substance0.038851Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.12930.02979Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.1620.04445Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.3711Moderately InformativeInherited
Biological Process (BP)generation of neurons00.0000001743InformativeDirect
Biological Process (BP)embryonic morphogenesis0.000015090.000002724InformativeDirect
Biological Process (BP)negative regulation of developmental process0.00012080.000001008InformativeDirect
Biological Process (BP)embryonic organ development0.00052930.00000000000276InformativeDirect
Biological Process (BP)regulation of cell proliferation0.0018230.2568InformativeInherited
Biological Process (BP)regulation of cell cycle process0.056051InformativeInherited
Biological Process (BP)epithelium development0.31390.2711InformativeInherited
Biological Process (BP)gland development0.020280.0004717InformativeInherited
Biological Process (BP)organ morphogenesis0.0013760.00002706InformativeInherited
Biological Process (BP)tube development0.012650.00000003105InformativeInherited
Biological Process (BP)blood circulation0.0000000027610.1545InformativeInherited
Biological Process (BP)single-organism behavior0.000049310.2549InformativeInherited
Biological Process (BP)response to organic cyclic compound0.015240.01419InformativeInherited
Biological Process (BP)response to lipid0.020320.000000002215InformativeInherited
Biological Process (BP)regulation of circadian rhythm0.0000000000063060.000000008767Highly InformativeDirect
Biological Process (BP)circadian rhythm0.00000001010.000001398Highly InformativeDirect
Biological Process (BP)negative regulation of cell differentiation0.0000066550.000001474Highly InformativeDirect
Biological Process (BP)cell fate commitment0.00001180Highly InformativeDirect
Biological Process (BP)regulation of neural precursor cell proliferation0.000000030570.02537Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.0020281Highly InformativeInherited
Biological Process (BP)aging0.0016110.6376Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process0.000012670.8978Highly InformativeInherited
Biological Process (BP)mammary gland epithelium development0.0000039510.04209Highly InformativeInherited
Biological Process (BP)mammary gland alveolus development0.00000098370.001164Highly InformativeInherited
Biological Process (BP)embryonic organ morphogenesis0.0012970.002333Highly InformativeInherited
Biological Process (BP)regulation of blood pressure0.0000000012580.08123Highly InformativeInherited
Biological Process (BP)locomotory behavior0.00000000013140.04483Highly InformativeInherited
Biological Process (BP)response to alcohol0.0011690.000005186Highly InformativeInherited
Molecular Function (MF)binding0.000022970Least InformativeDirect
Molecular Function (MF)nucleic acid binding0.014520Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding transcription factor activity0.00000000010250InformativeDirect
Molecular Function (MF)DNA binding0.00094440InformativeDirect
Molecular Function (MF)protein dimerization activity0.21390InformativeInherited
Molecular Function (MF)transcription factor binding0.000002820Highly InformativeDirect
Molecular Function (MF)protein heterodimerization activity0.000014160Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.024220Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.0000000000217 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00000001565 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0001092 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0001897 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.09728 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.07612 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.1455 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.001225 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.06727 Least Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000000006163 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000007118 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000000000004321 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.0000000000001894 Moderately Informative Direct
Biological Process (BP) organ development 0.000000000007497 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0002309 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) reproductive process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01911 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.04445 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.03542 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02979 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.464 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.03614 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.6613 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1688 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.009025 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.00283 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2092 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.02457 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9868 Moderately Informative Inherited
Biological Process (BP) generation of neurons 0.0000001743 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.000002724 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.000001008 Informative Direct
Biological Process (BP) embryonic organ development 0.00000000000276 Informative Direct
Biological Process (BP) organ morphogenesis 0.00002706 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0007977 Informative Direct
Biological Process (BP) tube development 0.00000003105 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 0 Informative Direct
Biological Process (BP) gland development 0.0004717 Informative Direct
Biological Process (BP) response to lipid 0.000000002215 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.00007434 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0001102 Informative Direct
Biological Process (BP) transcription, DNA-templated 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.000000000005203 Informative Direct
Biological Process (BP) chromosome organization 0.00000000007951 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.0000000006427 Informative Direct
Biological Process (BP) single organism reproductive process 0.000000001301 Informative Direct
Biological Process (BP) sensory organ development 0.0000006695 Informative Direct
Biological Process (BP) muscle structure development 0.000001322 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00008623 Informative Direct
Biological Process (BP) tissue morphogenesis 0.00009571 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000524 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.2568 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.01765 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.09927 Informative Inherited
Biological Process (BP) response to oxidative stress 0.8132 Informative Inherited
Biological Process (BP) cardiovascular system development 0.4075 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01419 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) localization of cell 0.3839 Informative Inherited
Biological Process (BP) locomotion 0.9315 Informative Inherited
Biological Process (BP) reproductive structure development 0.005128 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) cell projection organization 0.908 Informative Inherited
Biological Process (BP) regulation of cell development 0.009715 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02298 Informative Inherited
Biological Process (BP) regulation of secretion 0.00623 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Informative Inherited
Biological Process (BP) blood circulation 0.1545 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.2549 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.1289 Informative Inherited
Biological Process (BP) muscle system process 0.2281 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of response to wounding 1 Informative Inherited
Biological Process (BP) regulation of MAPK cascade 0.2582 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) apoptotic process 0.01013 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.798 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) leukocyte activation 0.07606 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.7941 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.7572 Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.001306 Informative Inherited
Biological Process (BP) response to nutrient levels 0.06484 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) central nervous system development 0.04342 Informative Inherited
Biological Process (BP) epithelium development 0.2711 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.155 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.3073 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.5251 Informative Inherited
Biological Process (BP) pigment metabolic process 0.2558 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.9814 Informative Inherited
Biological Process (BP) regulation of body fluid levels 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.35 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.0618 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.6465 Informative Inherited
Biological Process (BP) neurological system process 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.1721 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1213 Informative Inherited
Biological Process (BP) phosphorylation 0.9951 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.000000008767 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.000001398 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.000001474 Highly Informative Direct
Biological Process (BP) cell fate commitment 0 Highly Informative Direct
Biological Process (BP) response to alcohol 0.000005186 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.0000000000006096 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.00000000000006944 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.0000000000003584 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.000000000006785 Highly Informative Direct
Biological Process (BP) MAPK cascade 0.0000000008333 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.000000001192 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.000000006092 Highly Informative Direct
Biological Process (BP) placenta development 0.00000002779 Highly Informative Direct
Biological Process (BP) histone modification 0.00000008942 Highly Informative Direct
Biological Process (BP) stem cell development 0.0000001622 Highly Informative Direct
Biological Process (BP) negative regulation of cell division 0.000000217 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.000000421 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.0000009551 Highly Informative Direct
Biological Process (BP) muscle organ development 0.000001077 Highly Informative Direct
Biological Process (BP) regulation of binding 0.000001517 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.00001894 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.00001937 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.00002103 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.00003569 Highly Informative Direct
Biological Process (BP) neural tube development 0.00005944 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.00007376 Highly Informative Direct
Biological Process (BP) body fluid secretion 0.0001407 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0002264 Highly Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 0.0002884 Highly Informative Direct
Biological Process (BP) cellular response to metal ion 0.0004184 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0006415 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0006684 Highly Informative Direct
Biological Process (BP) collagen metabolic process 0.0008697 Highly Informative Direct
Biological Process (BP) regulation of hematopoietic progenitor cell differentiation 0.007826 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.07526 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.02537 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.009481 Highly Informative Inherited
Biological Process (BP) aging 0.6376 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.002694 Highly Informative Inherited
Biological Process (BP) kidney development 0.6012 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.9972 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.7441 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.8978 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.2201 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.04209 Highly Informative Inherited
Biological Process (BP) mammary gland alveolus development 0.001164 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.6839 Highly Informative Inherited
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 0.9324 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.2535 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.001723 Highly Informative Inherited
Biological Process (BP) gonad development 0.03954 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.4402 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 1 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.002333 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.08123 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.01982 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.8644 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.04483 Highly Informative Inherited
Biological Process (BP) positive regulation of response to wounding 0.1035 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 1 Highly Informative Inherited
Biological Process (BP) ear development 1 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.05943 Highly Informative Inherited
Biological Process (BP) ensheathment of neurons 0.004142 Highly Informative Inherited
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.09227 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.2075 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.006403 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.6839 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.1996 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 1 Highly Informative Inherited
Biological Process (BP) endocrine system development 0.06325 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.4539 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.1933 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.1367 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.05875 Highly Informative Inherited
Biological Process (BP) regulation of muscle system process 0.406 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) epidermis development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) pigment biosynthetic process 0.07638 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.225 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 1 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.008158 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.005299 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.01159 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.3246 Highly Informative Inherited
Biological Process (BP) ossification 0.1891 Highly Informative Inherited
Biological Process (BP) in utero embryonic development 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0843 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.6536 Informative Inherited
Molecular Function (MF) enzyme binding 0.7664 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.02536 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.7639 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.1616 Highly Informative Inherited
Cellular Component (CC) protein complex 0.000001734 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0000000000001715 Moderately Informative Direct
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) chromosome 0.08779 Informative Inherited
Cellular Component (CC) cytoplasmic ribonucleoprotein granule 0.0002562 Highly Informative Direct
Cellular Component (CC) chromatin 0.02641 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.2686 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0314Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.001353Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.3332Moderately InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.01744InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.2389InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm0.0000004938Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.3268Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7453Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.2332Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.08885InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.09722InformativeInherited
Phenotypic Abnormality (PA)Posteriorly rotated ears0.0008898Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.02813Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.00005797Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0.00006573Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.0001366Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.02515Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.2732Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7917Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.0006883Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.00768Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.008961Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.009049Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.009394Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.01937Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.06865Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.0828Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1255Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.1378Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2264Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.273Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.6401Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7482Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.7729Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.0001133InformativeDirect
Mammalian Phenotype (MP)abnormal neuron number0.004696InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.01175InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.07986InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.09835InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1235InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1422InformativeInherited
Mammalian Phenotype (MP)abnormal cell proliferation0.1534InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1936InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.2911InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.3762InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.3778InformativeInherited
Mammalian Phenotype (MP)abnormal telencephalon morphology0.6149InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.6932InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.000005677Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic acinus morphology0.00007343Highly InformativeDirect
Mammalian Phenotype (MP)thin retinal inner nuclear layer0.0002525Highly InformativeDirect
Mammalian Phenotype (MP)no abnormal phenotype detected0.0002677Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.0002707Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal bipolar cell morphology0.0002707Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal apoptosis0.0003761Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardiac epithelial to mesenchymal transition0.0003838Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.0004002Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0005593Highly InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon development0.001543Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CNS glial cell morphology0.00671Highly InformativeInherited
Mammalian Phenotype (MP)abnormal clavicle morphology0.01167Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.0132Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.2143Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.4196Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.6071Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.001148Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.0136Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.000182Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.7759Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.838Moderately InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.0009877InformativeDirect
Worm Phenotype (WP)neuron development variant0.01121InformativeInherited
Worm Phenotype (WP)ectopic expression transgene0.00001757Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.0001566Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.0004878Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0077Least InformativeInherited
Fly Anatomy (FA)organ system0.02438Least InformativeInherited
Fly Anatomy (FA)anatomical group0.03757Least InformativeInherited
Fly Anatomy (FA)adult0.055Least InformativeInherited
Fly Anatomy (FA)cell0.2245Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)external sensory organ0.01242Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.1191Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.1805Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.2047Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.3017Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.3052Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.4136Moderately InformativeInherited
Fly Anatomy (FA)appendage0.4251Moderately InformativeInherited
Fly Anatomy (FA)adult head0.4622Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.5038Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.9243Moderately InformativeInherited
Fly Anatomy (FA)chaeta0.0006032InformativeDirect
Fly Anatomy (FA)mechanosensory sensory organ0.01449InformativeInherited
Fly Anatomy (FA)adult external head0.02833InformativeInherited
Fly Anatomy (FA)antennal segment0.1278InformativeInherited
Fly Anatomy (FA)leg0.1424InformativeInherited
Fly Anatomy (FA)appendage segment0.1718InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.3278InformativeInherited
Fly Anatomy (FA)sensory mother cell0.000005684Highly InformativeDirect
Fly Anatomy (FA)third segment of antenna0.0002434Highly InformativeDirect
Fly Anatomy (FA)mesothoracic leg0.003431Highly InformativeInherited
Fly Anatomy (FA)head bristle0.008644Highly InformativeInherited
Fly Anatomy (FA)macrochaeta0.1287Highly InformativeInherited
Fly Anatomy (FA)segment of leg0.3484Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.1076Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.5994Least InformativeInherited
Zebrafish Anatomy (ZA)musculature system0.01162Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1Moderately InformativeInherited
Zebrafish Anatomy (ZA)smooth muscle cell0.0001361InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.03894Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.04232Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7641Least InformativeInherited
Xenopus ANatomical entity (XAN)cell0.9282Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.000000006704Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.0000634Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.0484Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.3405Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.5059Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00000000000003729InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.00000000002111InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00000001948InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.00000007461InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00000008244InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0000001286InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0000001889InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0000008821InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.000001047InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.000002161InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.0002126InformativeDirect
Xenopus ANatomical entity (XAN)hematological system0.01447InformativeInherited
Xenopus ANatomical entity (XAN)tail0.7093InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.841InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.9089InformativeInherited
Xenopus ANatomical entity (XAN)skin1InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.0000000000616Highly InformativeDirect
Xenopus ANatomical entity (XAN)retina0.000000001025Highly InformativeDirect
Xenopus ANatomical entity (XAN)proliferative region0.00000001539Highly InformativeDirect
Xenopus ANatomical entity (XAN)eye primordium0.0000001189Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.0000001898Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.0000002902Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.000001153Highly InformativeDirect
Xenopus ANatomical entity (XAN)sensorial layer of neurectoderm0.000001393Highly InformativeDirect
Xenopus ANatomical entity (XAN)myotome0.000001972Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system0.00000267Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.00000463Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.00003317Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted ventral mesoderm0.00004901Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.00005168Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.00005723Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.0001354Highly InformativeDirect
Xenopus ANatomical entity (XAN)blood vessel0.0002015Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.0002406Highly InformativeDirect
Xenopus ANatomical entity (XAN)lateral line system0.0005084Highly InformativeDirect
Xenopus ANatomical entity (XAN)fused heart primordium0.0005854Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.000726Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0007411Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0009972Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.002393Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0002621Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.0007314Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.00003533InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.003108InformativeInherited
Plant ANatomical entity (PAN)primary root0.0003535Highly InformativeDirect
Plant ANatomical entity (PAN)style0.001014Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processSteroid metabolism0.0000000003351InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processMyogenesis0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processCholesterol metabolism0.00000000000465Highly InformativeDirect
Biological processAdaptive immunity0.00007669Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Coding sequence diversityChromosomal rearrangement0.000008684InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DomainRepeat0.00006633Least InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00000005417Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationHydroxylation0.00000000006829InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011598 SSF47459 Protein matches
Abstract

The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundle of four helices in a left-handed twist with two crossover connections. The HLH domain directs dimerisation, and is juxtaposed to basic regions to create a DNA interaction interface surface that recognises specific DNA sequences. Basic region/HLH (bHLH) proteins regulate diverse biological pathways [PubMed10710415]. bHLH proteins include MyoD [PubMed12783965], SREBPs (sterol regulatory element binding proteins) [PubMed9634703], and yeast Pho4 (phosphatase system) [PubMed9303313].

In certain proteins the bHLH domain contains a leucine-zipper motif. The bHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a network of proteins and determines sequence-specific DNA binding [PubMed10378692]. bHLHZip domains occur in the transcription factors Myc, Mad, Max and Usf [PubMed12553908, PubMed8306960].

This entry is bHLHZip, which covers the bHLH domain and the leucine zipper motif, when present.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HLH, helix-loop-helix DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the HLH, helix-loop-helix DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]