SUPERFAMILY 1.75 HMM library and genome assignments server


HLH, helix-loop-helix DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HLH-like [ 47458] (2)
Superfamily:   HLH, helix-loop-helix DNA-binding domain [ 47459]
Families:   HLH, helix-loop-helix DNA-binding domain [ 47460] (8)


Superfamily statistics
Genomes (458) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,877 24,850 13
Proteins 25,808 24,800 13


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process3.098e-140Least InformativeDirect
Biological Process (BP)multicellular organismal process1.632e-120Least InformativeDirect
Biological Process (BP)response to stimulus8.002e-060Least InformativeDirect
Biological Process (BP)regulation of cellular process0.81990Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0032450Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.073140Least InformativeInherited
Biological Process (BP)regulation of biosynthetic process7.745e-140Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process1.168e-130Moderately InformativeDirect
Biological Process (BP)regulation of gene expression1.333e-130Moderately InformativeDirect
Biological Process (BP)regulation of developmental process1.111e-083.1e-12Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process6.749e-074.458e-05Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process3.237e-060.0007517Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.00037730.02034Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0091660.0246Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.010930Moderately InformativeInherited
Biological Process (BP)tissue development0.2281.832e-05Moderately InformativeInherited
Biological Process (BP)organ development0.21717.781e-09Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.098760.9789Moderately InformativeInherited
Biological Process (BP)system process0.33611Moderately InformativeInherited
Biological Process (BP)cell differentiation0.74610.0002423Moderately InformativeInherited
Biological Process (BP)nervous system development4.419e-050.1189Moderately InformativeInherited
Biological Process (BP)response to organic substance0.036251Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.12550.02699Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.15770.03419Moderately InformativeInherited
Biological Process (BP)generation of neurons01.401e-07InformativeDirect
Biological Process (BP)embryonic morphogenesis1.368e-063.279e-06InformativeDirect
Biological Process (BP)negative regulation of developmental process8.295e-053.574e-08InformativeDirect
Biological Process (BP)embryonic organ development0.00010431.264e-12InformativeDirect
Biological Process (BP)organ morphogenesis0.00012141.52e-05InformativeDirect
Biological Process (BP)regulation of cell cycle process0.05581InformativeInherited
Biological Process (BP)gland development0.0025644.697e-06InformativeInherited
Biological Process (BP)epithelium development0.30390.06137InformativeInherited
Biological Process (BP)blood circulation2.399e-090.1463InformativeInherited
Biological Process (BP)regulation of nervous system development0.0041170.03026InformativeInherited
Biological Process (BP)regulation of cell development0.010110.02615InformativeInherited
Biological Process (BP)single-organism behavior1.496e-080.9995InformativeInherited
Biological Process (BP)response to organic cyclic compound0.016210.01532InformativeInherited
Biological Process (BP)response to lipid0.019411.604e-09InformativeInherited
Biological Process (BP)response to hormone stimulus0.049051.667e-05InformativeInherited
Biological Process (BP)regulation of circadian rhythm7.281e-127.633e-09Highly InformativeDirect
Biological Process (BP)circadian rhythm9.982e-093.946e-07Highly InformativeDirect
Biological Process (BP)negative regulation of cell differentiation4.846e-067.94e-08Highly InformativeDirect
Biological Process (BP)cell fate commitment1.382e-050Highly InformativeDirect
Biological Process (BP)regulation of neural precursor cell proliferation3.321e-080.02328Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.0032061Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process1.613e-051Highly InformativeInherited
Biological Process (BP)mammary gland alveolus development6.758e-070.001273Highly InformativeInherited
Biological Process (BP)mammary gland epithelium development3.606e-060.02251Highly InformativeInherited
Biological Process (BP)embryonic organ morphogenesis0.001330.002629Highly InformativeInherited
Biological Process (BP)regulation of blood pressure1.367e-090.1035Highly InformativeInherited
Biological Process (BP)locomotory behavior9.095e-110.003382Highly InformativeInherited
Biological Process (BP)response to alcohol0.0011941.392e-05Highly InformativeInherited
Biological Process (BP)aging0.0004540.6224Highly InformativeInherited
Molecular Function (MF)binding1.465e-050Least InformativeDirect
Molecular Function (MF)nucleic acid binding0.010120Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding transcription factor activity9.555e-110InformativeDirect
Molecular Function (MF)DNA binding0.00085280InformativeDirect
Molecular Function (MF)protein dimerization activity0.21640InformativeInherited
Molecular Function (MF)sequence-specific DNA binding transcription factor activity7.759e-110Highly InformativeDirect
Molecular Function (MF)transcription factor binding2.731e-060Highly InformativeDirect
Molecular Function (MF)protein binding transcription factor activity4.105e-060Highly InformativeDirect
Molecular Function (MF)protein heterodimerization activity1.292e-050Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.012660Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 3.837e-09 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 2.905e-05 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 5.264e-05 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0003898 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.1063 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.03066 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.06407 Least Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 3.1e-12 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 4.458e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0007517 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 2.883e-12 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) organ development 7.781e-09 Moderately Informative Direct
Biological Process (BP) tissue development 1.832e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0002423 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) reproduction 3.124e-07 Moderately Informative Direct
Biological Process (BP) homeostatic process 1.559e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.02034 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.03419 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02217 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9789 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.0246 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1189 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8504 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02699 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.3623 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.02525 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1913 Moderately Informative Inherited
Biological Process (BP) generation of neurons 1.401e-07 Informative Direct
Biological Process (BP) embryonic morphogenesis 3.279e-06 Informative Direct
Biological Process (BP) negative regulation of developmental process 3.574e-08 Informative Direct
Biological Process (BP) embryonic organ development 1.264e-12 Informative Direct
Biological Process (BP) organ morphogenesis 1.52e-05 Informative Direct
Biological Process (BP) gland development 4.697e-06 Informative Direct
Biological Process (BP) response to lipid 1.604e-09 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) response to hormone stimulus 1.667e-05 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 1.864e-05 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 3.24e-05 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 2.755e-12 Informative Direct
Biological Process (BP) chromosome organization 4.986e-11 Informative Direct
Biological Process (BP) sensory organ development 4.255e-07 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 6.566e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 8.377e-05 Informative Direct
Biological Process (BP) muscle structure development 0.0001075 Informative Direct
Biological Process (BP) tube development 0.0003288 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0003454 Informative Direct
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01532 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.08282 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.4903 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.7143 Informative Inherited
Biological Process (BP) cardiovascular system development 0.3613 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) localization of cell 0.3505 Informative Inherited
Biological Process (BP) locomotion 0.9129 Informative Inherited
Biological Process (BP) reproductive system development 0.8189 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.01531 Informative Inherited
Biological Process (BP) regulation of secretion 0.003073 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) epithelium development 0.06137 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.154 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.6463 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) blood circulation 0.1463 Informative Inherited
Biological Process (BP) single-organism behavior 0.9995 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.05695 Informative Inherited
Biological Process (BP) response to oxidative stress 0.8433 Informative Inherited
Biological Process (BP) muscle system process 0.1341 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) apoptotic process 0.02072 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.724 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.7573 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.8249 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.9457 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9035 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.04692 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.03314 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.2134 Informative Inherited
Biological Process (BP) central nervous system development 0.03933 Informative Inherited
Biological Process (BP) leukocyte activation 0.07751 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.05737 Informative Inherited
Biological Process (BP) regulation of cell development 0.02615 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.03026 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.2572 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.6212 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.09884 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.7928 Informative Inherited
Biological Process (BP) regulation of circadian rhythm 7.633e-09 Highly Informative Direct
Biological Process (BP) circadian rhythm 3.946e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 7.94e-08 Highly Informative Direct
Biological Process (BP) cell fate commitment 0 Highly Informative Direct
Biological Process (BP) response to alcohol 1.392e-05 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 3.77e-15 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) iron ion homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 1.023e-13 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 2.286e-13 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 1.305e-11 Highly Informative Direct
Biological Process (BP) mesenchyme development 5.048e-11 Highly Informative Direct
Biological Process (BP) cellular transition metal ion homeostasis 8.883e-11 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 4.86e-09 Highly Informative Direct
Biological Process (BP) placenta development 2.474e-08 Highly Informative Direct
Biological Process (BP) histone modification 6.124e-08 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 8.862e-08 Highly Informative Direct
Biological Process (BP) stem cell development 1.551e-07 Highly Informative Direct
Biological Process (BP) regulation of binding 5.885e-07 Highly Informative Direct
Biological Process (BP) regulation of cell division 1.083e-06 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 1.183e-06 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 1.83e-05 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 2.553e-05 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 3.506e-05 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 7.399e-05 Highly Informative Direct
Biological Process (BP) neural tube development 8.193e-05 Highly Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 0.0002917 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0003047 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0003425 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0004012 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0006745 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.02328 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.007331 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.9704 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.09259 Highly Informative Inherited
Biological Process (BP) renal system development 0.4826 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.2336 Highly Informative Inherited
Biological Process (BP) mammary gland alveolus development 0.001273 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.6942 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.02251 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.001638 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.2391 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 1 Highly Informative Inherited
Biological Process (BP) axon development 1 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 1 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.0217 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.002629 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.1827 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.1035 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.003382 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.001672 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.09457 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.3575 Highly Informative Inherited
Biological Process (BP) ear development 0.9985 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.07452 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.8712 Highly Informative Inherited
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0.01094 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 1 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.04777 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.00705 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.05051 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.7006 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.02255 Highly Informative Inherited
Biological Process (BP) endocrine system development 0.06117 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.8769 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.3174 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.1912 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.1511 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.6911 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.7732 Highly Informative Inherited
Biological Process (BP) pigment biosynthetic process 0.4037 Highly Informative Inherited
Biological Process (BP) gonad development 0.03092 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.2212 Highly Informative Inherited
Biological Process (BP) aging 0.6224 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.9548 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.0086 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.005645 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.01001 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.2976 Highly Informative Inherited
Biological Process (BP) ossification 0.1577 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.7056 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.6092 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0 Highly Informative Direct
Molecular Function (MF) protein complex binding 9.971e-06 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.4421 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.02184 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 2.24e-09 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.04828 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) chromosome 0.09879 Informative Inherited
Cellular Component (CC) chromatin 0.000411 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.04696Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.002837Moderately InformativeInherited
Disease Ontology (DO)bone disease0.221Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.3412Moderately InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm1.327e-06InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.2348InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm6.964e-07Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.3308Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7474Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.2412Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.08568InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.09855InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.1602InformativeInherited
Phenotypic Abnormality (PA)Broad forehead0.0008971Highly InformativeDirect
Phenotypic Abnormality (PA)Posteriorly rotated ears0.0009527Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.03047Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging3.842e-05Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype7.679e-05Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0.0001112Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.03483Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.2825Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8092Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.001802Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.007238Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.00907Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.009314Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.009415Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.02035Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.07041Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.07948Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1169Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.1402Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2054Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2721Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.6446Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7219Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.8299Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation8.698e-05InformativeDirect
Mammalian Phenotype (MP)abnormal neuron number0.004042InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.01232InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.07868InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1098InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.1284InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1319InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.1421InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1859InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.2921InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.3675InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.6119InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.6801InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number4.68e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic acinus morphology9.147e-05Highly InformativeDirect
Mammalian Phenotype (MP)no abnormal phenotype detected0.000127Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.0001671Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal apoptosis0.000228Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal bipolar cell morphology0.0002292Highly InformativeDirect
Mammalian Phenotype (MP)thin retinal inner nuclear layer0.0002301Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardiac epithelial to mesenchymal transition0.0003243Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.0004413Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuronal precursor proliferation0.000502Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0005735Highly InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon development0.001288Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CNS glial cell morphology0.006505Highly InformativeInherited
Mammalian Phenotype (MP)abnormal clavicle morphology0.01224Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.01247Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.2117Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.4164Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.6184Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.001148Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.0136Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.000182Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.7759Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.838Moderately InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.0009877InformativeDirect
Worm Phenotype (WP)neuron development variant0.01121InformativeInherited
Worm Phenotype (WP)ectopic expression transgene1.757e-05Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.0001566Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.0004878Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.008007Least InformativeInherited
Fly Anatomy (FA)organ system0.02511Least InformativeInherited
Fly Anatomy (FA)anatomical group0.04057Least InformativeInherited
Fly Anatomy (FA)cell0.2355Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)cell cluster organ0.01293Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.02717Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1436Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.1865Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.2189Moderately InformativeInherited
Fly Anatomy (FA)appendage0.4175Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.5072Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.5568Moderately InformativeInherited
Fly Anatomy (FA)head0.8501Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.935Moderately InformativeInherited
Fly Anatomy (FA)chaeta0.0006355InformativeDirect
Fly Anatomy (FA)mechanosensory sensory organ0.01449InformativeInherited
Fly Anatomy (FA)adult external head0.02503InformativeInherited
Fly Anatomy (FA)antennal segment0.131InformativeInherited
Fly Anatomy (FA)leg0.1423InformativeInherited
Fly Anatomy (FA)appendage segment0.1816InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.5119InformativeInherited
Fly Anatomy (FA)sensory mother cell8.045e-06Highly InformativeDirect
Fly Anatomy (FA)third segment of antenna0.0002409Highly InformativeDirect
Fly Anatomy (FA)mesothoracic leg0.004116Highly InformativeInherited
Fly Anatomy (FA)head bristle0.008377Highly InformativeInherited
Fly Anatomy (FA)macrochaeta0.1331Highly InformativeInherited
Fly Anatomy (FA)segment of leg0.348Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.1121Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.5885Least InformativeInherited
Zebrafish Anatomy (ZA)musculature system0.01071Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1Moderately InformativeInherited
Zebrafish Anatomy (ZA)smooth muscle cell0.0001411InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.03698Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.04107Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7641Least InformativeInherited
Xenopus ANatomical entity (XAN)cell0.991Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure5.313e-09Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure5.612e-05Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.04602Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.3378Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.5033Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm3.299e-14InformativeDirect
Xenopus ANatomical entity (XAN)neural plate1.284e-11InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord1.455e-08InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain5.811e-08InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme6.303e-08InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system9.056e-08InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region1.614e-07InformativeDirect
Xenopus ANatomical entity (XAN)forebrain7.548e-07InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space7.618e-07InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode1.981e-06InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.0001779InformativeDirect
Xenopus ANatomical entity (XAN)hematological system0.01404InformativeInherited
Xenopus ANatomical entity (XAN)tail0.7073InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.8385InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.9073InformativeInherited
Xenopus ANatomical entity (XAN)skin1InformativeInherited
Xenopus ANatomical entity (XAN)neuron8.725e-10Highly InformativeDirect
Xenopus ANatomical entity (XAN)retina9.667e-10Highly InformativeDirect
Xenopus ANatomical entity (XAN)proliferative region1.536e-08Highly InformativeDirect
Xenopus ANatomical entity (XAN)eye primordium8.616e-08Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelium1.625e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border1.67e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge9.278e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)sensorial layer of neurectoderm1.401e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)myotome1.983e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system2.403e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube3.167e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle3.837e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain4.548e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted ventral mesoderm4.931e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system5.695e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.0001276Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural fold0.0002245Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.0002279Highly InformativeDirect
Xenopus ANatomical entity (XAN)fused heart primordium0.0005525Highly InformativeDirect
Xenopus ANatomical entity (XAN)lateral line system0.0005566Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0007251Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0008722Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.002403Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0002628Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.0007342Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis3.533e-05InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.003108InformativeInherited
Plant ANatomical entity (PAN)primary root0.0003535Highly InformativeDirect
Plant ANatomical entity (PAN)style0.001014Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processSteroid metabolism3.464e-10InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processCholesterol metabolism4.701e-12Highly InformativeDirect
Biological processAdaptive immunity7.717e-05Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Coding sequence diversityChromosomal rearrangement9.146e-06InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DomainRepeat6.215e-05Least InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation2.865e-07Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationHydroxylation6.974e-11InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011598 SSF47459 Protein matches
Abstract

The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundle of four helices in a left-handed twist with two crossover connections. The HLH domain directs dimerisation, and is juxtaposed to basic regions to create a DNA interaction interface surface that recognises specific DNA sequences. Basic region/HLH (bHLH) proteins regulate diverse biological pathways [PubMed10710415]. bHLH proteins include MyoD [PubMed12783965], SREBPs (sterol regulatory element binding proteins) [PubMed9634703], and yeast Pho4 (phosphatase system) [PubMed9303313].

In certain proteins the bHLH domain contains a leucine-zipper motif. The bHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a network of proteins and determines sequence-specific DNA binding [PubMed10378692]. bHLHZip domains occur in the transcription factors Myc, Mad, Max and Usf [PubMed12553908, PubMed8306960].

This entry is bHLHZip, which covers the bHLH domain and the leucine zipper motif, when present.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HLH, helix-loop-helix DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the HLH, helix-loop-helix DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]