SUPERFAMILY 1.75 HMM library and genome assignments server


HLH, helix-loop-helix DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HLH-like [ 47458] (2)
Superfamily:   HLH, helix-loop-helix DNA-binding domain [ 47459]
Families:   HLH, helix-loop-helix DNA-binding domain [ 47460] (8)


Superfamily statistics
Genomes (447) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 24,170 24,850 13
Proteins 24,111 24,800 13


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process2.174e-140Least InformativeDirect
Biological Process (BP)multicellular organismal process1.127e-120Least InformativeDirect
Biological Process (BP)response to stimulus5.926e-060Least InformativeDirect
Biological Process (BP)regulation of cellular process0.84890Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0031690Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.078030Least InformativeInherited
Biological Process (BP)regulation of biosynthetic process6.381e-140Moderately InformativeDirect
Biological Process (BP)regulation of gene expression9.482e-140Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process9.904e-140Moderately InformativeDirect
Biological Process (BP)regulation of developmental process1.385e-083.052e-12Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process7.465e-074.009e-05Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process3.467e-060.0007033Moderately InformativeDirect
Biological Process (BP)single-organism developmental process5.458e-050Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.00040040.02142Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.00940.02794Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.010990Moderately InformativeInherited
Biological Process (BP)tissue development0.22161.279e-05Moderately InformativeInherited
Biological Process (BP)organ development0.21345.395e-09Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.093430.9561Moderately InformativeInherited
Biological Process (BP)system process0.33721Moderately InformativeInherited
Biological Process (BP)cell differentiation0.73910.0002529Moderately InformativeInherited
Biological Process (BP)nervous system development4.551e-050.1123Moderately InformativeInherited
Biological Process (BP)response to organic substance0.034651Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.1180.01372Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.15920.03723Moderately InformativeInherited
Biological Process (BP)generation of neurons01.72e-07InformativeDirect
Biological Process (BP)embryonic morphogenesis1.368e-062.328e-06InformativeDirect
Biological Process (BP)embryonic organ development0.0001021.306e-12InformativeDirect
Biological Process (BP)negative regulation of developmental process0.00010423.274e-08InformativeDirect
Biological Process (BP)organ morphogenesis0.00010851.579e-05InformativeDirect
Biological Process (BP)regulation of cell proliferation0.0022440.2791InformativeInherited
Biological Process (BP)regulation of cell cycle process0.053581InformativeInherited
Biological Process (BP)gland development0.002655.368e-06InformativeInherited
Biological Process (BP)epithelium development0.31180.09872InformativeInherited
Biological Process (BP)blood circulation2.155e-090.136InformativeInherited
Biological Process (BP)regulation of nervous system development0.0041170.02704InformativeInherited
Biological Process (BP)regulation of cell development0.010440.02746InformativeInherited
Biological Process (BP)response to organic cyclic compound0.016860.01643InformativeInherited
Biological Process (BP)response to lipid0.019721.949e-09InformativeInherited
Biological Process (BP)response to hormone stimulus0.045189.783e-06InformativeInherited
Biological Process (BP)single-organism behavior1.271e-081InformativeInherited
Biological Process (BP)regulation of circadian rhythm8.009e-123.648e-09Highly InformativeDirect
Biological Process (BP)locomotory behavior7.014e-110.0005386Highly InformativeDirect
Biological Process (BP)circadian rhythm8.457e-093.778e-07Highly InformativeDirect
Biological Process (BP)negative regulation of cell differentiation6.372e-068.114e-08Highly InformativeDirect
Biological Process (BP)cell fate commitment1.476e-050Highly InformativeDirect
Biological Process (BP)regulation of neural precursor cell proliferation3.403e-080.02221Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.0032361Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process1.528e-051Highly InformativeInherited
Biological Process (BP)mammary gland alveolus development7.016e-070.001305Highly InformativeInherited
Biological Process (BP)mammary gland epithelium development3.778e-060.02161Highly InformativeInherited
Biological Process (BP)embryonic organ morphogenesis0.0012870.002675Highly InformativeInherited
Biological Process (BP)regulation of blood pressure1.449e-090.1072Highly InformativeInherited
Biological Process (BP)aging0.00043810.6146Highly InformativeInherited
Molecular Function (MF)binding1.147e-050Least InformativeDirect
Molecular Function (MF)nucleic acid binding0.0097270Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding transcription factor activity8.804e-110InformativeDirect
Molecular Function (MF)DNA binding0.00081640InformativeDirect
Molecular Function (MF)protein dimerization activity0.21720InformativeInherited
Molecular Function (MF)sequence-specific DNA binding transcription factor activity7.145e-110Highly InformativeDirect
Molecular Function (MF)transcription factor binding2.832e-060Highly InformativeDirect
Molecular Function (MF)protein binding transcription factor activity3.769e-060Highly InformativeDirect
Molecular Function (MF)protein heterodimerization activity1.288e-050Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.011070Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1.503e-09 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1.364e-05 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 2.581e-05 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0001984 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.1005 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.01937 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.04347 Least Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 3.052e-12 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 4.009e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0007033 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1.252e-12 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) organ development 5.395e-09 Moderately Informative Direct
Biological Process (BP) tissue development 1.279e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0002529 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) reproduction 1.083e-06 Moderately Informative Direct
Biological Process (BP) homeostatic process 1.538e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.02142 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.03723 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.0227 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9561 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.02794 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9321 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1123 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.01372 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.3804 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.02187 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1489 Moderately Informative Inherited
Biological Process (BP) generation of neurons 1.72e-07 Informative Direct
Biological Process (BP) embryonic morphogenesis 2.328e-06 Informative Direct
Biological Process (BP) embryonic organ development 1.306e-12 Informative Direct
Biological Process (BP) negative regulation of developmental process 3.274e-08 Informative Direct
Biological Process (BP) organ morphogenesis 1.579e-05 Informative Direct
Biological Process (BP) gland development 5.368e-06 Informative Direct
Biological Process (BP) response to lipid 1.949e-09 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) response to hormone stimulus 9.783e-06 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 2.658e-05 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 2.743e-05 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 2.005e-12 Informative Direct
Biological Process (BP) chromosome organization 2.463e-11 Informative Direct
Biological Process (BP) sensory organ development 4.206e-07 Informative Direct
Biological Process (BP) programmed cell death 5.292e-07 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 4.462e-05 Informative Direct
Biological Process (BP) muscle structure development 8.186e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 8.339e-05 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0002823 Informative Direct
Biological Process (BP) tube development 0.0003495 Informative Direct
Biological Process (BP) regulation of response to stress 0.05594 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.2791 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01643 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.08427 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.4499 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.6669 Informative Inherited
Biological Process (BP) cardiovascular system development 0.3705 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) localization of cell 0.3202 Informative Inherited
Biological Process (BP) locomotion 0.8702 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.813 Informative Inherited
Biological Process (BP) reproductive system development 0.8341 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.01575 Informative Inherited
Biological Process (BP) regulation of secretion 0.002303 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) epithelium development 0.09872 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.145 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) blood circulation 0.136 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.05367 Informative Inherited
Biological Process (BP) response to oxidative stress 0.8464 Informative Inherited
Biological Process (BP) muscle system process 0.09905 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.8016 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.9266 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.8752 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.07272 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.02744 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.2322 Informative Inherited
Biological Process (BP) central nervous system development 0.03559 Informative Inherited
Biological Process (BP) leukocyte activation 0.07704 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.05509 Informative Inherited
Biological Process (BP) regulation of cell development 0.02746 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02704 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.2407 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.6186 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.08168 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.7673 Informative Inherited
Biological Process (BP) regulation of circadian rhythm 3.648e-09 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.0005386 Highly Informative Direct
Biological Process (BP) circadian rhythm 3.778e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 8.114e-08 Highly Informative Direct
Biological Process (BP) cell fate commitment 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 2.402e-06 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 1.922e-15 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 0 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) iron ion homeostasis 0 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 1.213e-13 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 1.336e-13 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 1.024e-11 Highly Informative Direct
Biological Process (BP) mesenchyme development 4.403e-11 Highly Informative Direct
Biological Process (BP) cellular transition metal ion homeostasis 9.109e-11 Highly Informative Direct
Biological Process (BP) cellular response to alcohol 1.247e-10 Highly Informative Direct
Biological Process (BP) placenta development 2.749e-08 Highly Informative Direct
Biological Process (BP) histone modification 3.935e-08 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 9.174e-08 Highly Informative Direct
Biological Process (BP) stem cell development 1.074e-07 Highly Informative Direct
Biological Process (BP) regulation of binding 4.008e-07 Highly Informative Direct
Biological Process (BP) regulation of cell division 7.538e-07 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 1.399e-06 Highly Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 4.901e-06 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 1.527e-05 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 2.63e-05 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 3.092e-05 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 8.951e-05 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0002958 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0003377 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0003415 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0005886 Highly Informative Direct
Biological Process (BP) lactation 0.0007714 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.02221 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.008309 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.9579 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.08276 Highly Informative Inherited
Biological Process (BP) renal system development 0.484 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.2386 Highly Informative Inherited
Biological Process (BP) mammary gland alveolus development 0.001305 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.6961 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.02161 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.001707 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.2459 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 1 Highly Informative Inherited
Biological Process (BP) axon development 1 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 1 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.0201 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.002675 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.193 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.1072 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.001705 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.09931 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.4574 Highly Informative Inherited
Biological Process (BP) inner ear development 0.3163 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.07586 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.8726 Highly Informative Inherited
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0.01022 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 1 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.04413 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.006846 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.04776 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.6807 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.02262 Highly Informative Inherited
Biological Process (BP) endocrine system development 0.06232 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.8895 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.182 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.1089 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.702 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.7771 Highly Informative Inherited
Biological Process (BP) pigment biosynthetic process 0.4073 Highly Informative Inherited
Biological Process (BP) gonad development 0.02878 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.2146 Highly Informative Inherited
Biological Process (BP) aging 0.6146 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.9608 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.008898 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.00489 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.007633 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.2809 Highly Informative Inherited
Biological Process (BP) ossification 0.1507 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.6306 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.5796 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) protein complex binding 7.707e-06 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.01989 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 1.972e-09 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.04708 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) chromosome 0.09247 Informative Inherited
Cellular Component (CC) transcription factor complex 0 Highly Informative Direct
Cellular Component (CC) chromatin 0.0002915 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.04609Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.002753Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.3348Moderately InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm1.214e-06InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.2366InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm6.291e-07Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.3341Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7484Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.2416Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.1002InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.03158Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging3.964e-05Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype8.232e-05Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0.0001142Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.05116Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.2848Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8113Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.00183Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.007109Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.009369Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.009611Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.009744Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.02009Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.07153Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.07965Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1145Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.1403Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2065Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2656Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.6443Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.718Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.8617Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation5.251e-05InformativeDirect
Mammalian Phenotype (MP)abnormal neuron number0.003781InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.01287InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.07966InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1085InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.1292InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1336InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.143InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1872InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.2824InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.3594InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.6143InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.6809InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number4.898e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic acinus morphology9.359e-05Highly InformativeDirect
Mammalian Phenotype (MP)no abnormal phenotype detected0.0001301Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.0001692Highly InformativeDirect
Mammalian Phenotype (MP)thin retinal inner nuclear layer0.0001718Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal apoptosis0.0001794Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal bipolar cell morphology0.0001986Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardiac epithelial to mesenchymal transition0.000328Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.0004562Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuronal precursor proliferation0.0005149Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0006188Highly InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon development0.001316Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CNS glial cell morphology0.006313Highly InformativeInherited
Mammalian Phenotype (MP)abnormal clavicle morphology0.01222Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.0124Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.2127Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.4351Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.6117Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.001148Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.0136Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.000182Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.7759Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.838Moderately InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.0009877InformativeDirect
Worm Phenotype (WP)neuron development variant0.01121InformativeInherited
Worm Phenotype (WP)ectopic expression transgene1.757e-05Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.0001566Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.0004878Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.02061Least InformativeInherited
Fly Anatomy (FA)organ system0.02242Least InformativeInherited
Fly Anatomy (FA)anatomical group0.07569Least InformativeInherited
Fly Anatomy (FA)cell0.2294Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)cell cluster organ0.02575Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.05379Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.1414Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1838Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.254Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.2576Moderately InformativeInherited
Fly Anatomy (FA)appendage0.4683Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.5226Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.5888Moderately InformativeInherited
Fly Anatomy (FA)head0.839Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.9493Moderately InformativeInherited
Fly Anatomy (FA)chaeta0.001855InformativeInherited
Fly Anatomy (FA)mechanosensory system0.02099InformativeInherited
Fly Anatomy (FA)adult external head0.02725InformativeInherited
Fly Anatomy (FA)antennal segment0.1284InformativeInherited
Fly Anatomy (FA)leg0.1539InformativeInherited
Fly Anatomy (FA)appendage segment0.2079InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.5158InformativeInherited
Fly Anatomy (FA)sensory mother cell7.065e-06Highly InformativeDirect
Fly Anatomy (FA)mesothoracic leg0.004084Highly InformativeInherited
Fly Anatomy (FA)head bristle0.008882Highly InformativeInherited
Fly Anatomy (FA)macrochaeta0.1382Highly InformativeInherited
Fly Anatomy (FA)segment of leg0.3729Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.1116Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.5827Least InformativeInherited
Zebrafish Anatomy (ZA)musculature system0.01098Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1Moderately InformativeInherited
Zebrafish Anatomy (ZA)smooth muscle cell0.0001337InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.03671Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.04105Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7643Least InformativeInherited
Xenopus ANatomical entity (XAN)cell0.9905Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure2.052e-08Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.0001645Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.1128Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.3358Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.5035Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm2.614e-13InformativeDirect
Xenopus ANatomical entity (XAN)neural plate6.336e-11InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme5.461e-08InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord7.484e-08InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain2.799e-07InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system4.622e-07InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region6.353e-07InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space3.285e-06InformativeDirect
Xenopus ANatomical entity (XAN)forebrain3.503e-06InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode6.402e-06InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.0001075InformativeDirect
Xenopus ANatomical entity (XAN)hematological system0.01403InformativeInherited
Xenopus ANatomical entity (XAN)tail0.7062InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.8344InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.9073InformativeInherited
Xenopus ANatomical entity (XAN)skin1InformativeInherited
Xenopus ANatomical entity (XAN)neuron8.716e-10Highly InformativeDirect
Xenopus ANatomical entity (XAN)retina6.506e-09Highly InformativeDirect
Xenopus ANatomical entity (XAN)proliferative region1.536e-08Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelium1.373e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border1.67e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge9.273e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)sensorial layer of neurectoderm1.399e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube1.696e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)myotome1.982e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system2.264e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted ventral mesoderm4.458e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system5.223e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0001645Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0001841Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural fold0.0002143Highly InformativeDirect
Xenopus ANatomical entity (XAN)fused heart primordium0.0005519Highly InformativeDirect
Xenopus ANatomical entity (XAN)lateral line system0.0005569Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0006508Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.0006869Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0008736Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.002404Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0002632Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.0007353Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis3.533e-05InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.003108InformativeInherited
Plant ANatomical entity (PAN)primary root0.0003535Highly InformativeDirect
Plant ANatomical entity (PAN)style0.001014Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processSteroid metabolism3.019e-10InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processCholesterol metabolism4.601e-12Highly InformativeDirect
Biological processAdaptive immunity7.771e-05Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Coding sequence diversityChromosomal rearrangement9.15e-06InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DomainRepeat6.308e-05Least InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation2.396e-07Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationHydroxylation7.228e-11InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011598 SSF47459 Protein matches
Abstract

The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundle of four helices in a left-handed twist with two crossover connections. The HLH domain directs dimerisation, and is juxtaposed to basic regions to create a DNA interaction interface surface that recognises specific DNA sequences. Basic region/HLH (bHLH) proteins regulate diverse biological pathways [PubMed10710415]. bHLH proteins include MyoD [PubMed12783965], SREBPs (sterol regulatory element binding proteins) [PubMed9634703], and yeast Pho4 (phosphatase system) [PubMed9303313].

In certain proteins the bHLH domain contains a leucine-zipper motif. The bHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a network of proteins and determines sequence-specific DNA binding [PubMed10378692]. bHLHZip domains occur in the transcription factors Myc, Mad, Max and Usf [PubMed12553908, PubMed8306960].

This entry is bHLHZip, which covers the bHLH domain and the leucine zipper motif, when present.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HLH, helix-loop-helix DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the HLH, helix-loop-helix DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]