SUPERFAMILY 1.75 HMM library and genome assignments server


HLH, helix-loop-helix DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HLH-like [ 47458] (2)
Superfamily:   HLH, helix-loop-helix DNA-binding domain [ 47459]
Families:   HLH, helix-loop-helix DNA-binding domain [ 47460] (8)


Superfamily statistics
Genomes (458) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,877 24,850 13
Proteins 25,808 24,800 13


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process3.625e-140Least InformativeDirect
Biological Process (BP)multicellular organismal process1.771e-120Least InformativeDirect
Biological Process (BP)response to stimulus1.021e-050Least InformativeDirect
Biological Process (BP)regulation of cellular process0.82140Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.072980Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0030660Least InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process1.253e-140Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process6.23e-140Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process1.482e-130Moderately InformativeDirect
Biological Process (BP)regulation of gene expression2.075e-130Moderately InformativeDirect
Biological Process (BP)regulation of developmental process1.22e-084.849e-12Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process7.765e-074.87e-05Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.00040620.02251Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0092470.02988Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.01240Moderately InformativeInherited
Biological Process (BP)tissue development0.22722.574e-05Moderately InformativeInherited
Biological Process (BP)organ development0.22171.718e-09Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.10070.9882Moderately InformativeInherited
Biological Process (BP)system process0.34291Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.59811Moderately InformativeInherited
Biological Process (BP)cell differentiation0.71360.0001816Moderately InformativeInherited
Biological Process (BP)nervous system development4.723e-050.1103Moderately InformativeInherited
Biological Process (BP)response to organic substance0.036831Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.12560.02864Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.15980.03945Moderately InformativeInherited
Biological Process (BP)generation of neurons01.566e-07InformativeDirect
Biological Process (BP)embryonic morphogenesis1.309e-063.13e-06InformativeDirect
Biological Process (BP)negative regulation of developmental process0.0001024.56e-08InformativeDirect
Biological Process (BP)embryonic organ development0.00010611.566e-12InformativeDirect
Biological Process (BP)organ morphogenesis0.0001331.808e-05InformativeDirect
Biological Process (BP)regulation of cell proliferation0.0020360.2558InformativeInherited
Biological Process (BP)regulation of cell cycle process0.057271InformativeInherited
Biological Process (BP)gland development0.0024635.653e-06InformativeInherited
Biological Process (BP)epithelium development0.3050.06511InformativeInherited
Biological Process (BP)blood circulation2.449e-090.1532InformativeInherited
Biological Process (BP)regulation of nervous system development0.0039390.02602InformativeInherited
Biological Process (BP)regulation of cell development0.012360.03102InformativeInherited
Biological Process (BP)single-organism behavior1.866e-081InformativeInherited
Biological Process (BP)response to organic cyclic compound0.015420.01375InformativeInherited
Biological Process (BP)response to lipid0.020542.045e-09InformativeInherited
Biological Process (BP)response to hormone stimulus0.047521.414e-05InformativeInherited
Biological Process (BP)regulation of circadian rhythm6.474e-129.055e-09Highly InformativeDirect
Biological Process (BP)circadian rhythm1.016e-081.197e-06Highly InformativeDirect
Biological Process (BP)negative regulation of cell differentiation6.326e-069.393e-08Highly InformativeDirect
Biological Process (BP)cell fate commitment1.331e-050Highly InformativeDirect
Biological Process (BP)regulation of neural precursor cell proliferation3.239e-080.02606Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.0029271Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process1.454e-050.9749Highly InformativeInherited
Biological Process (BP)mammary gland alveolus development6.669e-070.001295Highly InformativeInherited
Biological Process (BP)mammary gland epithelium development3.564e-060.02166Highly InformativeInherited
Biological Process (BP)embryonic organ morphogenesis0.0013470.00253Highly InformativeInherited
Biological Process (BP)regulation of blood pressure1.175e-090.1011Highly InformativeInherited
Biological Process (BP)locomotory behavior1.117e-100.006194Highly InformativeInherited
Biological Process (BP)response to alcohol0.0011634.875e-06Highly InformativeInherited
Biological Process (BP)aging0.00044040.6553Highly InformativeInherited
Molecular Function (MF)binding2.107e-050Least InformativeDirect
Molecular Function (MF)nucleic acid binding0.01090Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding transcription factor activity1.025e-100InformativeDirect
Molecular Function (MF)DNA binding0.00091170InformativeDirect
Molecular Function (MF)protein dimerization activity0.2130InformativeInherited
Molecular Function (MF)sequence-specific DNA binding transcription factor activity8.327e-110Highly InformativeDirect
Molecular Function (MF)transcription factor binding2.852e-060Highly InformativeDirect
Molecular Function (MF)protein heterodimerization activity1.41e-050Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.013390Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1.609e-08 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 6.034e-05 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0001081 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0007688 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.1392 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.04911 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1137 Least Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 4.849e-12 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 4.87e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 3.759e-12 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) organ development 1.718e-09 Moderately Informative Direct
Biological Process (BP) tissue development 2.574e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0001816 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) reproduction 4.794e-07 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.02251 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.03945 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01913 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9882 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.02988 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1103 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8947 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02864 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.355 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.01978 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2104 Moderately Informative Inherited
Biological Process (BP) generation of neurons 1.566e-07 Informative Direct
Biological Process (BP) embryonic morphogenesis 3.13e-06 Informative Direct
Biological Process (BP) negative regulation of developmental process 4.56e-08 Informative Direct
Biological Process (BP) embryonic organ development 1.566e-12 Informative Direct
Biological Process (BP) organ morphogenesis 1.808e-05 Informative Direct
Biological Process (BP) gland development 5.653e-06 Informative Direct
Biological Process (BP) response to lipid 2.045e-09 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) response to hormone stimulus 1.414e-05 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 1.295e-05 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 7.132e-05 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 3.984e-12 Informative Direct
Biological Process (BP) chromosome organization 7.727e-11 Informative Direct
Biological Process (BP) sensory organ development 4.775e-07 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 6.394e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0001151 Informative Direct
Biological Process (BP) muscle structure development 0.0001328 Informative Direct
Biological Process (BP) tube development 0.0003129 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0004562 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.2558 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01375 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.09675 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.5342 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.7534 Informative Inherited
Biological Process (BP) cardiovascular system development 0.3793 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) localization of cell 0.3748 Informative Inherited
Biological Process (BP) locomotion 0.93 Informative Inherited
Biological Process (BP) reproductive system development 0.8396 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.005088 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) epithelium development 0.06511 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.1643 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) blood circulation 0.1532 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.06141 Informative Inherited
Biological Process (BP) response to oxidative stress 0.8715 Informative Inherited
Biological Process (BP) muscle system process 0.1369 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) apoptotic process 0.02205 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.723 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.7519 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.9928 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9359 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.05302 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.05233 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1967 Informative Inherited
Biological Process (BP) central nervous system development 0.03047 Informative Inherited
Biological Process (BP) leukocyte activation 0.07776 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.06154 Informative Inherited
Biological Process (BP) regulation of cell development 0.03102 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02602 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.2573 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.0834 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1134 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.7968 Informative Inherited
Biological Process (BP) regulation of circadian rhythm 9.055e-09 Highly Informative Direct
Biological Process (BP) circadian rhythm 1.197e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 9.393e-08 Highly Informative Direct
Biological Process (BP) cell fate commitment 0 Highly Informative Direct
Biological Process (BP) response to alcohol 4.875e-06 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 7.357e-14 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 2.825e-13 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 4.266e-11 Highly Informative Direct
Biological Process (BP) mesenchyme development 7.83e-11 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 4.483e-09 Highly Informative Direct
Biological Process (BP) placenta development 2.186e-08 Highly Informative Direct
Biological Process (BP) histone modification 7.675e-08 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 1.46e-07 Highly Informative Direct
Biological Process (BP) stem cell development 1.519e-07 Highly Informative Direct
Biological Process (BP) regulation of binding 6.835e-07 Highly Informative Direct
Biological Process (BP) regulation of cell division 7.201e-07 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 8.357e-07 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 1.653e-05 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 2.131e-05 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 2.634e-05 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 7.305e-05 Highly Informative Direct
Biological Process (BP) neural tube development 7.79e-05 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0002573 Highly Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 0.0002879 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.00034 Highly Informative Direct
Biological Process (BP) cellular response to metal ion 0.0004082 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0004822 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.02606 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.008085 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.9869 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.9749 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.08096 Highly Informative Inherited
Biological Process (BP) renal system development 0.4907 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.23 Highly Informative Inherited
Biological Process (BP) mammary gland alveolus development 0.001295 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.679 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.02166 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.001472 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.001668 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.2363 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.4513 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle cell differentiation 0.6003 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.00253 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.216 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.1011 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.006194 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.001769 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.1005 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.3497 Highly Informative Inherited
Biological Process (BP) ear development 1 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.05583 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.8858 Highly Informative Inherited
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.07022 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 1 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.05109 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.006651 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.05665 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.6908 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.02189 Highly Informative Inherited
Biological Process (BP) endocrine system development 0.05969 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.8733 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.4587 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.1955 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.1414 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.6833 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.6698 Highly Informative Inherited
Biological Process (BP) pigment biosynthetic process 0.3856 Highly Informative Inherited
Biological Process (BP) gonad development 0.03264 Highly Informative Inherited
Biological Process (BP) cytoskeleton-dependent intracellular transport 0.04649 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.2226 Highly Informative Inherited
Biological Process (BP) aging 0.6553 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 1 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.008703 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.00549 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.01029 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.3029 Highly Informative Inherited
Biological Process (BP) ossification 0.1541 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0576 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.7552 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.6495 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) protein complex binding 1.206e-05 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.1612 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.02463 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 2.86e-09 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.03699 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) chromosome 0.09363 Informative Inherited
Cellular Component (CC) chromatin 0.000431 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0314Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.001353Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.3332Moderately InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.01744InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.2389InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm4.938e-07Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.3268Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7453Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.2332Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.08885InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.09722InformativeInherited
Phenotypic Abnormality (PA)Posteriorly rotated ears0.0008898Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.02813Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging5.797e-05Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype6.573e-05Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.0001366Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.02515Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.2732Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7917Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.0006883Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.00768Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.008961Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.009049Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.009394Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.01937Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.06865Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.0828Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1255Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.1378Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2264Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.273Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.6401Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7482Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.7729Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.0001133InformativeDirect
Mammalian Phenotype (MP)abnormal neuron number0.004696InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.01175InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.07986InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.09835InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1235InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1422InformativeInherited
Mammalian Phenotype (MP)abnormal cell proliferation0.1534InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1936InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.2911InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.3762InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.3778InformativeInherited
Mammalian Phenotype (MP)abnormal telencephalon morphology0.6149InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.6932InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number5.677e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic acinus morphology7.343e-05Highly InformativeDirect
Mammalian Phenotype (MP)thin retinal inner nuclear layer0.0002525Highly InformativeDirect
Mammalian Phenotype (MP)no abnormal phenotype detected0.0002677Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.0002707Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal bipolar cell morphology0.0002707Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal apoptosis0.0003761Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardiac epithelial to mesenchymal transition0.0003838Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.0004002Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0005593Highly InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon development0.001543Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CNS glial cell morphology0.00671Highly InformativeInherited
Mammalian Phenotype (MP)abnormal clavicle morphology0.01167Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.0132Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.2143Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.4196Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.6071Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.001148Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.0136Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.000182Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.7759Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.838Moderately InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.0009877InformativeDirect
Worm Phenotype (WP)neuron development variant0.01121InformativeInherited
Worm Phenotype (WP)ectopic expression transgene1.757e-05Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.0001566Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.0004878Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0077Least InformativeInherited
Fly Anatomy (FA)organ system0.02438Least InformativeInherited
Fly Anatomy (FA)anatomical group0.03757Least InformativeInherited
Fly Anatomy (FA)adult0.055Least InformativeInherited
Fly Anatomy (FA)cell0.2245Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)external sensory organ0.01242Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.1191Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.1805Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.2047Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.3017Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.3052Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.4136Moderately InformativeInherited
Fly Anatomy (FA)appendage0.4251Moderately InformativeInherited
Fly Anatomy (FA)adult head0.4622Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.5038Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.9243Moderately InformativeInherited
Fly Anatomy (FA)chaeta0.0006032InformativeDirect
Fly Anatomy (FA)mechanosensory sensory organ0.01449InformativeInherited
Fly Anatomy (FA)adult external head0.02833InformativeInherited
Fly Anatomy (FA)antennal segment0.1278InformativeInherited
Fly Anatomy (FA)leg0.1424InformativeInherited
Fly Anatomy (FA)appendage segment0.1718InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.3278InformativeInherited
Fly Anatomy (FA)sensory mother cell5.684e-06Highly InformativeDirect
Fly Anatomy (FA)third segment of antenna0.0002434Highly InformativeDirect
Fly Anatomy (FA)mesothoracic leg0.003431Highly InformativeInherited
Fly Anatomy (FA)head bristle0.008644Highly InformativeInherited
Fly Anatomy (FA)macrochaeta0.1287Highly InformativeInherited
Fly Anatomy (FA)segment of leg0.3484Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.1076Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.5994Least InformativeInherited
Zebrafish Anatomy (ZA)musculature system0.01162Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1Moderately InformativeInherited
Zebrafish Anatomy (ZA)smooth muscle cell0.0001361InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.03894Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.04232Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7641Least InformativeInherited
Xenopus ANatomical entity (XAN)cell0.9282Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure6.704e-09Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure6.34e-05Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.0484Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.3405Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.5059Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm3.729e-14InformativeDirect
Xenopus ANatomical entity (XAN)neural plate2.111e-11InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord1.948e-08InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain7.461e-08InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme8.244e-08InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system1.286e-07InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region1.889e-07InformativeDirect
Xenopus ANatomical entity (XAN)forebrain8.821e-07InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space1.047e-06InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode2.161e-06InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.0002126InformativeDirect
Xenopus ANatomical entity (XAN)hematological system0.01447InformativeInherited
Xenopus ANatomical entity (XAN)tail0.7093InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.841InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.9089InformativeInherited
Xenopus ANatomical entity (XAN)skin1InformativeInherited
Xenopus ANatomical entity (XAN)neuron6.16e-11Highly InformativeDirect
Xenopus ANatomical entity (XAN)retina1.025e-09Highly InformativeDirect
Xenopus ANatomical entity (XAN)proliferative region1.539e-08Highly InformativeDirect
Xenopus ANatomical entity (XAN)eye primordium1.189e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelium1.898e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border2.902e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge1.153e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)sensorial layer of neurectoderm1.393e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)myotome1.972e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system2.67e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube4.63e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region3.317e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted ventral mesoderm4.901e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle5.168e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain5.723e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.0001354Highly InformativeDirect
Xenopus ANatomical entity (XAN)blood vessel0.0002015Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.0002406Highly InformativeDirect
Xenopus ANatomical entity (XAN)lateral line system0.0005084Highly InformativeDirect
Xenopus ANatomical entity (XAN)fused heart primordium0.0005854Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.000726Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0007411Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0009972Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.002393Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0002621Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.0007314Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis3.533e-05InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.003108InformativeInherited
Plant ANatomical entity (PAN)primary root0.0003535Highly InformativeDirect
Plant ANatomical entity (PAN)style0.001014Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processSteroid metabolism3.351e-10InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processMyogenesis0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processCholesterol metabolism4.65e-12Highly InformativeDirect
Biological processAdaptive immunity7.669e-05Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Coding sequence diversityChromosomal rearrangement8.684e-06InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DomainRepeat6.633e-05Least InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation5.417e-08Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationHydroxylation6.829e-11InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011598 SSF47459 Protein matches
Abstract

The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundle of four helices in a left-handed twist with two crossover connections. The HLH domain directs dimerisation, and is juxtaposed to basic regions to create a DNA interaction interface surface that recognises specific DNA sequences. Basic region/HLH (bHLH) proteins regulate diverse biological pathways [PubMed10710415]. bHLH proteins include MyoD [PubMed12783965], SREBPs (sterol regulatory element binding proteins) [PubMed9634703], and yeast Pho4 (phosphatase system) [PubMed9303313].

In certain proteins the bHLH domain contains a leucine-zipper motif. The bHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a network of proteins and determines sequence-specific DNA binding [PubMed10378692]. bHLHZip domains occur in the transcription factors Myc, Mad, Max and Usf [PubMed12553908, PubMed8306960].

This entry is bHLHZip, which covers the bHLH domain and the leucine zipper motif, when present.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HLH, helix-loop-helix DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the HLH, helix-loop-helix DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]