SUPERFAMILY 1.75 HMM library and genome assignments server

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HLH, helix-loop-helix DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HLH-like [ 47458] (2)
Superfamily:   HLH, helix-loop-helix DNA-binding domain [ 47459]
Families:   HLH, helix-loop-helix DNA-binding domain [ 47460] (8)


Superfamily statistics
Genomes (458) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,877 24,850 13
Proteins 25,808 24,800 13


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process0.000000000000033330Least InformativeDirect
Biological Process (BP)multicellular organismal process0.0000000000017020Least InformativeDirect
Biological Process (BP)response to stimulus0.0000097630Least InformativeDirect
Biological Process (BP)regulation of cellular process0.81550Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0030670Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.074440Least InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0000000000000094660Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process0.000000000000056350Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00000000000015470Moderately InformativeDirect
Biological Process (BP)regulation of gene expression0.00000000000017180Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0000000099590.000000000002643Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.0000006490.00003459Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.0000033210.0007387Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.000053320Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.00037860.01792Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0092730.02634Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.01120Moderately InformativeInherited
Biological Process (BP)tissue development0.22710.00001756Moderately InformativeInherited
Biological Process (BP)organ development0.21870.000000008389Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.098580.9706Moderately InformativeInherited
Biological Process (BP)system process0.33761Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.59351Moderately InformativeInherited
Biological Process (BP)cell differentiation0.73870.0002328Moderately InformativeInherited
Biological Process (BP)nervous system development0.000043230.124Moderately InformativeInherited
Biological Process (BP)response to organic substance0.036291Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.1250.02758Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.15520.0342Moderately InformativeInherited
Biological Process (BP)generation of neurons00.000000134InformativeDirect
Biological Process (BP)embryonic morphogenesis0.0000013230.000002809InformativeDirect
Biological Process (BP)negative regulation of developmental process0.000078950.00000003113InformativeDirect
Biological Process (BP)embryonic organ development0.00010470.000000000001334InformativeDirect
Biological Process (BP)organ morphogenesis0.0001220.00001378InformativeDirect
Biological Process (BP)regulation of cell proliferation0.002120.2513InformativeInherited
Biological Process (BP)regulation of cell cycle process0.058321InformativeInherited
Biological Process (BP)gland development0.0025760.000004119InformativeInherited
Biological Process (BP)epithelium development0.30410.06156InformativeInherited
Biological Process (BP)blood circulation0.0000000024630.1543InformativeInherited
Biological Process (BP)regulation of nervous system development0.0043040.02766InformativeInherited
Biological Process (BP)regulation of cell development0.01010.02451InformativeInherited
Biological Process (BP)single-organism behavior0.000000016841InformativeInherited
Biological Process (BP)response to organic cyclic compound0.015790.01437InformativeInherited
Biological Process (BP)response to lipid0.019070.000000001597InformativeInherited
Biological Process (BP)response to hormone stimulus0.047770.00001445InformativeInherited
Biological Process (BP)regulation of circadian rhythm0.0000000000068440.00000001021Highly InformativeDirect
Biological Process (BP)circadian rhythm0.00000001020.0000005761Highly InformativeDirect
Biological Process (BP)negative regulation of cell differentiation0.0000045930.00000006337Highly InformativeDirect
Biological Process (BP)cell fate commitment0.000013760Highly InformativeDirect
Biological Process (BP)regulation of neural precursor cell proliferation0.000000032940.01825Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.0031321Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process0.000016141Highly InformativeInherited
Biological Process (BP)mammary gland alveolus development0.0000006760.001278Highly InformativeInherited
Biological Process (BP)mammary gland epithelium development0.0000036190.02271Highly InformativeInherited
Biological Process (BP)embryonic organ morphogenesis0.001340.002348Highly InformativeInherited
Biological Process (BP)regulation of blood pressure0.0000000012460.1054Highly InformativeInherited
Biological Process (BP)locomotory behavior0.00000000011230.006888Highly InformativeInherited
Biological Process (BP)response to alcohol0.001170.00000466Highly InformativeInherited
Biological Process (BP)aging0.00045450.628Highly InformativeInherited
Molecular Function (MF)binding0.000020560Least InformativeDirect
Molecular Function (MF)nucleic acid binding0.010960Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding transcription factor activity0.00000000010350InformativeDirect
Molecular Function (MF)DNA binding0.00091560InformativeDirect
Molecular Function (MF)protein dimerization activity0.21240InformativeInherited
Molecular Function (MF)sequence-specific DNA binding transcription factor activity0.000000000084090Highly InformativeDirect
Molecular Function (MF)transcription factor binding0.0000026060Highly InformativeDirect
Molecular Function (MF)protein binding transcription factor activity0.0000046090Highly InformativeDirect
Molecular Function (MF)protein heterodimerization activity0.000013210Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.013180Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00000001456 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.00005704 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0001031 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0007342 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.1356 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.04752 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.09981 Least Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000000002643 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00003459 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0007387 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000000000003434 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) organ development 0.000000008389 Moderately Informative Direct
Biological Process (BP) tissue development 0.00001756 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0002328 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000004448 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.01792 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.0342 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02172 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9706 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.02634 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.124 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8628 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02758 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.3774 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.02818 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2098 Moderately Informative Inherited
Biological Process (BP) generation of neurons 0.000000134 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.000002809 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.00000003113 Informative Direct
Biological Process (BP) embryonic organ development 0.000000000001334 Informative Direct
Biological Process (BP) organ morphogenesis 0.00001378 Informative Direct
Biological Process (BP) gland development 0.000004119 Informative Direct
Biological Process (BP) response to lipid 0.000000001597 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) response to hormone stimulus 0.00001445 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.00001264 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.00003466 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.00000000000358 Informative Direct
Biological Process (BP) chromosome organization 0.00000000007347 Informative Direct
Biological Process (BP) sensory organ development 0.0000003655 Informative Direct
Biological Process (BP) muscle structure development 0.0001067 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0001093 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0001102 Informative Direct
Biological Process (BP) tube development 0.0003043 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0004417 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.2513 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01437 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.08192 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.4882 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.7116 Informative Inherited
Biological Process (BP) cardiovascular system development 0.3674 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) localization of cell 0.3726 Informative Inherited
Biological Process (BP) locomotion 0.9324 Informative Inherited
Biological Process (BP) reproductive system development 0.8249 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.00399 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) epithelium development 0.06156 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.1559 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) blood circulation 0.1543 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.06237 Informative Inherited
Biological Process (BP) response to oxidative stress 0.8594 Informative Inherited
Biological Process (BP) muscle system process 0.1397 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) apoptotic process 0.023 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.7227 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.748 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.8629 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.9793 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9106 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.05041 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.04781 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.2056 Informative Inherited
Biological Process (BP) central nervous system development 0.04392 Informative Inherited
Biological Process (BP) leukocyte activation 0.07789 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.0573 Informative Inherited
Biological Process (BP) regulation of cell development 0.02451 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02766 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.2552 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.08334 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.09882 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.7885 Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.00000001021 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0000005761 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.00000006337 Highly Informative Direct
Biological Process (BP) cell fate commitment 0 Highly Informative Direct
Biological Process (BP) response to alcohol 0.00000466 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.000000000000001931 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.00000000000009082 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.0000000000003101 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.00000000002246 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.00000000005615 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.000000004039 Highly Informative Direct
Biological Process (BP) placenta development 0.000000025 Highly Informative Direct
Biological Process (BP) histone modification 0.00000008346 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0000001057 Highly Informative Direct
Biological Process (BP) stem cell development 0.0000001623 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0000005392 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.0000008135 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.000001057 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.00001559 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.000021 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.00002101 Highly Informative Direct
Biological Process (BP) neural tube development 0.00007556 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.00008218 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0002612 Highly Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 0.0002643 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0003582 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0003865 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0009824 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.01825 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.006219 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.9924 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.07444 Highly Informative Inherited
Biological Process (BP) renal system development 0.4834 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.233 Highly Informative Inherited
Biological Process (BP) mammary gland alveolus development 0.001278 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.6807 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.02271 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.001617 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.2281 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.4653 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.02069 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.002348 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.1755 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.1054 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.006888 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.001809 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.09709 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.3435 Highly Informative Inherited
Biological Process (BP) ear development 1 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.06533 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.8874 Highly Informative Inherited
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0.01128 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 1 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.04913 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.006644 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.05493 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.6903 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.0218 Highly Informative Inherited
Biological Process (BP) endocrine system development 0.05565 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.8748 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.4608 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.1967 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.1439 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.6883 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.6319 Highly Informative Inherited
Biological Process (BP) pigment biosynthetic process 0.3872 Highly Informative Inherited
Biological Process (BP) gonad development 0.0315 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.2237 Highly Informative Inherited
Biological Process (BP) aging 0.628 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 1 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.007908 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.005616 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.01038 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.2901 Highly Informative Inherited
Biological Process (BP) ossification 0.1542 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0647 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.7301 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.6475 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.00001028 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.02436 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0.000000002513 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.04048 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) chromosome 0.09266 Informative Inherited
Cellular Component (CC) chromatin 0.0004585 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.02962Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.002961Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.3326Moderately InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.0000009921InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.2353InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm0.000000487Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.3271Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7454Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.2319Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.0882InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.09663InformativeInherited
Phenotypic Abnormality (PA)Posteriorly rotated ears0.0008972Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.02773Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.00003829Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.00007549Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0.0001039Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.02658Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.2827Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8111Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.0008784Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.006863Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.008973Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.008984Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.009462Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.02013Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.07038Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.08Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1176Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.1401Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2097Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2705Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7234Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.7894Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.0001053InformativeDirect
Mammalian Phenotype (MP)abnormal neuron number0.004012InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.01245InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.07814InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1079InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.1295InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1899InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.2938InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.3638InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.3704InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.6819InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.000004314Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic acinus morphology0.00008972Highly InformativeDirect
Mammalian Phenotype (MP)no abnormal phenotype detected0.0001323Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.0001858Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal bipolar cell morphology0.0002169Highly InformativeDirect
Mammalian Phenotype (MP)thin retinal inner nuclear layer0.0002279Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal apoptosis0.0002681Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardiac epithelial to mesenchymal transition0.0003207Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.0004431Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuronal precursor proliferation0.0004941Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0005614Highly InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon development0.001254Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CNS glial cell morphology0.006585Highly InformativeInherited
Mammalian Phenotype (MP)abnormal clavicle morphology0.01223Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.01258Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.2108Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.4191Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.6187Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.001148Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.0136Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.000182Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.7759Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.838Moderately InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.0009877InformativeDirect
Worm Phenotype (WP)neuron development variant0.01121InformativeInherited
Worm Phenotype (WP)ectopic expression transgene0.00001757Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.0001566Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.0004878Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.00766Least InformativeInherited
Fly Anatomy (FA)organ system0.02433Least InformativeInherited
Fly Anatomy (FA)anatomical group0.03777Least InformativeInherited
Fly Anatomy (FA)adult0.05478Least InformativeInherited
Fly Anatomy (FA)cell0.2254Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)external sensory organ0.01248Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.1191Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.1809Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.2041Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.3004Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.3064Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.4126Moderately InformativeInherited
Fly Anatomy (FA)appendage0.4237Moderately InformativeInherited
Fly Anatomy (FA)adult head0.4641Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.5029Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.924Moderately InformativeInherited
Fly Anatomy (FA)chaeta0.0006069InformativeDirect
Fly Anatomy (FA)mechanosensory sensory organ0.01449InformativeInherited
Fly Anatomy (FA)adult external head0.02851InformativeInherited
Fly Anatomy (FA)antennal segment0.1277InformativeInherited
Fly Anatomy (FA)leg0.1429InformativeInherited
Fly Anatomy (FA)appendage segment0.1721InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.3275InformativeInherited
Fly Anatomy (FA)sensory mother cell0.000005684Highly InformativeDirect
Fly Anatomy (FA)third segment of antenna0.000244Highly InformativeDirect
Fly Anatomy (FA)mesothoracic leg0.003459Highly InformativeInherited
Fly Anatomy (FA)head bristle0.008646Highly InformativeInherited
Fly Anatomy (FA)macrochaeta0.1287Highly InformativeInherited
Fly Anatomy (FA)segment of leg0.3483Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.114Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.6052Least InformativeInherited
Zebrafish Anatomy (ZA)musculature system0.01105Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1Moderately InformativeInherited
Zebrafish Anatomy (ZA)smooth muscle cell0.0001417InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.03783Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.04157Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7642Least InformativeInherited
Xenopus ANatomical entity (XAN)cell0.9922Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.000000006023Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.00006128Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.04712Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.3386Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.5034Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00000000000003726InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00000001719InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.000000024InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.00000007192InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00000008298InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0000001025InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0000001773InformativeDirect
Xenopus ANatomical entity (XAN)pre-chordal neural plate0.0000001989InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0000008863InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0000009094InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.000002118InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.0001758InformativeDirect
Xenopus ANatomical entity (XAN)hematological system0.01403InformativeInherited
Xenopus ANatomical entity (XAN)tail0.7083InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.8404InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.9075InformativeInherited
Xenopus ANatomical entity (XAN)skin1InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.0000000008731Highly InformativeDirect
Xenopus ANatomical entity (XAN)retina0.000000001031Highly InformativeDirect
Xenopus ANatomical entity (XAN)proliferative region0.00000001537Highly InformativeDirect
Xenopus ANatomical entity (XAN)eye primordium0.00000008562Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.0000001618Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.0000002015Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.0000009252Highly InformativeDirect
Xenopus ANatomical entity (XAN)sensorial layer of neurectoderm0.000001397Highly InformativeDirect
Xenopus ANatomical entity (XAN)myotome0.000001978Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system0.000002694Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.000004278Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.00004223Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted ventral mesoderm0.0000492Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.00005382Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.00005696Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.0001272Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural fold0.0002341Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.000237Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.0002417Highly InformativeDirect
Xenopus ANatomical entity (XAN)fused heart primordium0.000553Highly InformativeDirect
Xenopus ANatomical entity (XAN)lateral line system0.0005543Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0007253Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0009553Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.002397Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0002641Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.00074Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.00003533InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.003108InformativeInherited
Plant ANatomical entity (PAN)primary root0.0003535Highly InformativeDirect
Plant ANatomical entity (PAN)style0.001014Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processSteroid metabolism0.0000000003464InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processCholesterol metabolism0.000000000004701Highly InformativeDirect
Biological processAdaptive immunity0.00007717Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Coding sequence diversityChromosomal rearrangement0.000009146InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DomainRepeat0.00006215Least InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0000002865Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationHydroxylation0.00000000006974InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011598 SSF47459 Protein matches
Abstract

The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundle of four helices in a left-handed twist with two crossover connections. The HLH domain directs dimerisation, and is juxtaposed to basic regions to create a DNA interaction interface surface that recognises specific DNA sequences. Basic region/HLH (bHLH) proteins regulate diverse biological pathways [PubMed10710415]. bHLH proteins include MyoD [PubMed12783965], SREBPs (sterol regulatory element binding proteins) [PubMed9634703], and yeast Pho4 (phosphatase system) [PubMed9303313].

In certain proteins the bHLH domain contains a leucine-zipper motif. The bHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a network of proteins and determines sequence-specific DNA binding [PubMed10378692]. bHLHZip domains occur in the transcription factors Myc, Mad, Max and Usf [PubMed12553908, PubMed8306960].

This entry is bHLHZip, which covers the bHLH domain and the leucine zipper motif, when present.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HLH, helix-loop-helix DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the HLH, helix-loop-helix DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]