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lambda repressor-like DNA-binding domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   lambda repressor-like DNA-binding domains [ 47412]
Superfamily:   lambda repressor-like DNA-binding domains [ 47413] (13)
Families:   POU-specific domain [ 47414] (3)
  Phage repressors [ 47419] (7)
  SinR domain-like [ 47432] (8)
  Cyanase N-terminal domain [ 47435]
  GalR/LacI-like bacterial regulator [ 47438] (4)
  YdiL-like [ 109813] (2)
  CUT domain [ 116891] (4)
  Probable transcriptional regulator VC1968, N-terminal domain [ 116898]
  Bacteriophage CII protein [ 140520]
  NE0471 C-terminal domain-like [ 140523]
  PrgX N-terminal domain-like [ 140526]
  EDF1-like [ 140529]
  NE1354 [ 140532] (2)


Superfamily statistics
Genomes (2,951) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 60,336 409,262 80
Proteins 59,436 407,008 80


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.82090.0000005621Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.12550Least InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0015510Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.012540Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.013890Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0049120Moderately InformativeInherited
Molecular Function (MF)binding10.00000238Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.00025070Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity0.00010640InformativeDirect
Molecular Function (MF)DNA binding0.000001810InformativeDirect
Molecular Function (MF)sequence-specific DNA binding transcription factor activity0.000094250Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000004695 Least Informative Direct
Biological Process (BP) developmental process 0.00000002 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0000005621 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8562 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8985 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) nervous system development 0.00009983 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000013 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0000131 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.00001232 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00000000183 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0002217 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.2934 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2414 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.5396 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.002993 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.007143 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) system process 0.4611 Moderately Informative Inherited
Biological Process (BP) organ development 0.005328 Moderately Informative Inherited
Biological Process (BP) gene expression 0.02563 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.008463 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) transcription, DNA-dependent 0.00000000002139 Informative Direct
Biological Process (BP) sensory organ development 0.000374 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00000002737 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000000000000001938 Informative Direct
Biological Process (BP) cell projection organization 0.0009976 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0000000333 Informative Direct
Biological Process (BP) leukocyte activation 0.0009597 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.00000000002702 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.00002193 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00003423 Informative Direct
Biological Process (BP) negative regulation of cell death 0.6029 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.5698 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.4623 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.672 Informative Inherited
Biological Process (BP) tube development 0.05514 Informative Inherited
Biological Process (BP) epithelium development 0.4856 Informative Inherited
Biological Process (BP) organ morphogenesis 0.9128 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.297 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.2059 Informative Inherited
Biological Process (BP) generation of neurons 0.086 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.6624 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2319 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1269 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.5727 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.668 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3434 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.2796 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.4572 Informative Inherited
Biological Process (BP) secretion by cell 0.006729 Informative Inherited
Biological Process (BP) gland development 0.604 Informative Inherited
Biological Process (BP) central nervous system development 0.009038 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.03932 Informative Inherited
Biological Process (BP) single-organism behavior 0.3124 Informative Inherited
Biological Process (BP) chromosome organization 0.5285 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.2255 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) learning or memory 0.0005384 Highly Informative Direct
Biological Process (BP) hormone transport 0.00002982 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0008217 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0000001916 Highly Informative Direct
Biological Process (BP) diencephalon development 0.00008897 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.00002644 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0003418 Highly Informative Direct
Biological Process (BP) endocrine system development 0.000000000000007347 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.000002486 Highly Informative Direct
Biological Process (BP) amide transport 0.0003006 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.000004852 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.000003955 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 0.00004123 Highly Informative Direct
Biological Process (BP) respiratory system development 0.0002065 Highly Informative Direct
Biological Process (BP) renal system development 0.000009833 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.00000255 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.006951 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.06432 Highly Informative Inherited
Biological Process (BP) ear development 0.01289 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.06028 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.00893 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.551 Highly Informative Inherited
Biological Process (BP) B cell activation 0.004054 Highly Informative Inherited
Biological Process (BP) signal release 0.07602 Highly Informative Inherited
Biological Process (BP) sensory perception 0.05033 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.5389 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.7265 Highly Informative Inherited
Molecular Function (MF) binding 0.00000238 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0.00000001002 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00004464 Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0.0000000003539 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000001234 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.2383 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.01447 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.00191 Least Informative Inherited
Cellular Component (CC) nuclear part 0.0008467 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.000000000006195 Moderately Informative Direct
Cellular Component (CC) nucleoplasm part 0.00000008694 Informative Direct
Cellular Component (CC) chromosome 0.006082 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism segment morphology variant0.004634Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.00001966InformativeDirect
Worm Phenotype (WP)male tail morphology variant0.0000007122Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)sensory perception defective0.000717InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.07846Least InformativeInherited
Fly Anatomy (FA)anatomical group0.0899Least InformativeInherited
Fly Anatomy (FA)adult0.09409Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1215Least InformativeInherited
Fly Anatomy (FA)larva0.1635Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.0004405Moderately InformativeDirect
Fly Anatomy (FA)adult sense organ0.0076Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.01027Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01086Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.01648Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.02003Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.02234Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.02701Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05919Moderately InformativeInherited
Fly Anatomy (FA)appendage0.0673Moderately InformativeInherited
Fly Anatomy (FA)adult head0.1369Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.206Moderately InformativeInherited
Fly Anatomy (FA)antennal segment0.000002361InformativeDirect
Fly Anatomy (FA)supraesophageal ganglion0.00000547InformativeDirect
Fly Anatomy (FA)adult external head0.000007317InformativeDirect
Fly Anatomy (FA)chemosensory system0.000008507InformativeDirect
Fly Anatomy (FA)synaptic neuropil0.00001683InformativeDirect
Fly Anatomy (FA)neuromere0.00001724InformativeDirect
Fly Anatomy (FA)adult brain0.00001859InformativeDirect
Fly Anatomy (FA)adult procephalic segment0.00006167InformativeDirect
Fly Anatomy (FA)interneuron0.01224InformativeInherited
Fly Anatomy (FA)sensory organ cell0.02021InformativeInherited
Fly Anatomy (FA)appendage segment0.022InformativeInherited
Fly Anatomy (FA)antennal lobe glomerulus VA1v0.000000005701Highly InformativeDirect
Fly Anatomy (FA)maxillary palpus0.000001918Highly InformativeDirect
Fly Anatomy (FA)eo neuron0.000002178Highly InformativeDirect
Fly Anatomy (FA)unilateral ACT relay interneuron0.000002364Highly InformativeDirect
Fly Anatomy (FA)antennal lobe projection neuron iPN0.000002364Highly InformativeDirect
Fly Anatomy (FA)sensillum basiconicum0.0001041Highly InformativeDirect
Fly Anatomy (FA)chemosensory neuron0.0006853Highly InformativeDirect
Fly Anatomy (FA)olfactory sensory organ0.1101Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)brain0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.2784Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.5002Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.6671Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.01012Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.3407Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.3762Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.0001086InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0002225InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.02304InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.7687InformativeInherited
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.00003698Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.00005773Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.6857Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processPurine biosynthesis0InformativeDirect
Biological processCell shape0.0000000000001307InformativeDirect
Biological processNeurogenesis0.000009435InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentCell membrane0.985Moderately InformativeInherited
Cellular componentCell inner membrane0.00002069InformativeDirect
Developmental stageEarly protein0.00000000007599Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0.003282Least InformativeInherited
UniPathway (UP)NAD(+) biosynthesis0.0000002799InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR010982 SSF47413 Protein matches
Abstract

Bacteriophage lambda C1 repressor controls the expression of viral genes as part of the lysogeny/lytic growth switch. C1 is essential for maintaining lysogeny, where the phage replicates non-disruptively along with the host. If the host cell is threatened, then lytic growth is induced. The Lambda C1 repressor consists of two domains connected by a linker: an N-terminal DNA-binding domain that also mediates interactions with RNA polymerase, and a C-terminal dimerisation domain [PubMed10892750]. The DNA-binding domain consists of four helices in a closed folded leaf motif. Several different phage repressors from different helix-turn-helix families contain DNA-binding domains that adopt a similar topology. These include the Lambda Cro repressor, Bacteriophage 434 C1 and Cro repressors, P22 C2 repressor, and Bacteriophage Mu Ner protein.

The DNA-binding domain of Bacillus subtilis spore inhibition repressor SinR is identical to that of phage repressors [PubMed9799632]. SinR represses sporulation, which only occurs in response to adverse conditions. This provides a possible evolutionary link between the two adaptive responses of bacterial sporulation and prophage induction.

Other DNA-binding domains also display similar structural folds to that of Lambda C1. These include bacterial regulators such as the purine repressor (PurR), the lactose repressor (Lacr) and the fructose repressor (FruR), each of which has an N-terminal DNA-binding domain that exhibits a fold similar to that of lambda C1, except that they lack the first helix [PubMed7973627, PubMed10700279, PubMed9237914]. POU-specific domains found in transcription factors such as in Oct-1, Pit-1 and Hepatocyte nuclear factor 1a (LFB1/HNF1) display four-helical fold DNA-binding domains similar to that of Lambda C1 [PubMed11583619, PubMed9009203, PubMed12453420]. The N-terminal domain of cyanase has an alpha-helix bundle motif similar to Lambda C1, but it probably does not bind DNA. Cyanase is an enzyme found in bacteria and plants that catalyses the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide in response to extracellular cyanate [PubMed10801492].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a lambda repressor-like DNA-binding domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the lambda repressor-like DNA-binding domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]