SUPERFAMILY 1.75 HMM library and genome assignments server


lambda repressor-like DNA-binding domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   lambda repressor-like DNA-binding domains [ 47412]
Superfamily:   lambda repressor-like DNA-binding domains [ 47413] (13)
Families:   POU-specific domain [ 47414] (3)
  Phage repressors [ 47419] (7)
  SinR domain-like [ 47432] (8)
  Cyanase N-terminal domain [ 47435]
  GalR/LacI-like bacterial regulator [ 47438] (4)
  YdiL-like [ 109813] (2)
  CUT domain [ 116891] (4)
  Probable transcriptional regulator VC1968, N-terminal domain [ 116898]
  Bacteriophage CII protein [ 140520]
  NE0471 C-terminal domain-like [ 140523]
  PrgX N-terminal domain-like [ 140526]
  EDF1-like [ 140529]
  NE1354 [ 140532] (2)


Superfamily statistics
Genomes (2,317) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 45,570 174,175 80
Proteins 44,775 172,913 80


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.74590Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.067270Least InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.013490Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process0.0021550Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.0015230Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0021820Moderately InformativeInherited
Molecular Function (MF)binding10.05495Least InformativeInherited
Molecular Function (MF)heterocyclic compound binding0.21970Moderately InformativeInherited
Molecular Function (MF)organic cyclic compound binding0.25610Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding transcription factor activity1.456e-060InformativeDirect
Molecular Function (MF)DNA binding0.00030830InformativeDirect
Molecular Function (MF)sequence-specific DNA binding transcription factor activity1.271e-060Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 2.92e-06 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0006893 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1.305e-06 Moderately Informative Direct
Biological Process (BP) cell differentiation 1.53e-14 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.565e-08 Moderately Informative Direct
Biological Process (BP) organ development 1.615e-06 Moderately Informative Direct
Biological Process (BP) tissue development 5.702e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.1417 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9904 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.002227 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.8944 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.00473 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.005185 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.007821 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.03071 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.3399 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9298 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8514 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.007995 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.3447 Moderately Informative Inherited
Biological Process (BP) gene expression 0.575 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of gene expression 2.528e-06 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 3.142e-05 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0001836 Informative Direct
Biological Process (BP) transcription, DNA-dependent 1.582e-06 Informative Direct
Biological Process (BP) embryonic morphogenesis 2.048e-05 Informative Direct
Biological Process (BP) sensory organ development 0.0002384 Informative Direct
Biological Process (BP) cell activation 0.0004096 Informative Direct
Biological Process (BP) negative regulation of signaling 0.7452 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.8735 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9227 Informative Inherited
Biological Process (BP) tube development 0.02834 Informative Inherited
Biological Process (BP) epithelium development 0.5662 Informative Inherited
Biological Process (BP) organ morphogenesis 0.8823 Informative Inherited
Biological Process (BP) cell projection organization 0.008514 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1688 Informative Inherited
Biological Process (BP) generation of neurons 0.2092 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.3569 Informative Inherited
Biological Process (BP) secretion 0.003022 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.09654 Informative Inherited
Biological Process (BP) gland development 0.7309 Informative Inherited
Biological Process (BP) central nervous system development 0.01269 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.02665 Informative Inherited
Biological Process (BP) locomotion 0.1027 Informative Inherited
Biological Process (BP) response to external stimulus 0.435 Informative Inherited
Biological Process (BP) chromosome organization 0.4777 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.3187 Informative Inherited
Biological Process (BP) immune effector process 0.3275 Informative Inherited
Biological Process (BP) immune response 0.9203 Informative Inherited
Biological Process (BP) protein transport 0.9474 Informative Inherited
Biological Process (BP) chordate embryonic development 0.01599 Informative Inherited
Biological Process (BP) endocrine system development 1.679e-13 Highly Informative Direct
Biological Process (BP) kidney development 7.732e-11 Highly Informative Direct
Biological Process (BP) lymphocyte differentiation 9.158e-09 Highly Informative Direct
Biological Process (BP) cell fate commitment 3.986e-06 Highly Informative Direct
Biological Process (BP) hormone transport 4.969e-06 Highly Informative Direct
Biological Process (BP) epidermis development 5.174e-06 Highly Informative Direct
Biological Process (BP) inner ear development 1.401e-05 Highly Informative Direct
Biological Process (BP) diencephalon development 5.351e-05 Highly Informative Direct
Biological Process (BP) amide transport 6.266e-05 Highly Informative Direct
Biological Process (BP) sensory perception 0.0003413 Highly Informative Direct
Biological Process (BP) negative regulation of signal transduction 0.1038 Highly Informative Inherited
Biological Process (BP) gastrulation 0.002208 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.009308 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.01027 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.3474 Highly Informative Inherited
Biological Process (BP) B cell activation 0.004601 Highly Informative Inherited
Biological Process (BP) signal release 0.001384 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.002521 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.02997 Highly Informative Inherited
Biological Process (BP) axonogenesis 0.2085 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.01498 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.4123 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.6779 Highly Informative Inherited
Molecular Function (MF) binding 0.05495 Least Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) chromatin binding 3.834e-12 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 9.014e-09 Highly Informative Direct
Molecular Function (MF) transcription factor binding 4.711e-06 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.2779 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.03286 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.00699 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 4.049e-11 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0005838 Moderately Informative Direct
Cellular Component (CC) nucleoplasm part 2.586e-07 Informative Direct
Cellular Component (CC) chromosome 0.004238 Informative Inherited
Cellular Component (CC) transcription factor complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3499Least InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.08956Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1616Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.07948InformativeInherited
Mammalian Phenotype (MP)abnormal cerebrum morphology0.4669InformativeInherited
Mammalian Phenotype (MP)abnormal neurocranium morphology0.01603Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cerebral cortex morphology0.03408Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism segment morphology variant0.004634Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant1.966e-05InformativeDirect
Worm Phenotype (WP)male tail morphology variant7.122e-07Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality during development0Least InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0.0002288Moderately InformativeDirect
Fly Phenotype (FP)sensory perception defective0.0001129InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.08512Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.13Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)head0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.0004222Moderately InformativeDirect
Fly Anatomy (FA)anatomical group0.00577Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.01226Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01295Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.02618Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.04712Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05913Moderately InformativeInherited
Fly Anatomy (FA)appendage0.07756Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2241Moderately InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain3.039e-06InformativeDirect
Fly Anatomy (FA)chemosensory sensory organ3.929e-06InformativeDirect
Fly Anatomy (FA)adult external head8.876e-06InformativeDirect
Fly Anatomy (FA)neuromere1.026e-05InformativeDirect
Fly Anatomy (FA)adult head segment4.983e-05InformativeDirect
Fly Anatomy (FA)sensory neuron0.0038InformativeInherited
Fly Anatomy (FA)ganglion0.005642InformativeInherited
Fly Anatomy (FA)procephalic segment0.01454InformativeInherited
Fly Anatomy (FA)appendage segment0.02778InformativeInherited
Fly Anatomy (FA)antennal lobe glomerulus VA1v2.854e-09Highly InformativeDirect
Fly Anatomy (FA)antennal lobe projection neuron iPN8.789e-07Highly InformativeDirect
Fly Anatomy (FA)mushroom body extrinsic neuron8.789e-07Highly InformativeDirect
Fly Anatomy (FA)uniglomerular antennal lobe projection neuron1.1e-06Highly InformativeDirect
Fly Anatomy (FA)eo neuron1.252e-06Highly InformativeDirect
Fly Anatomy (FA)antennal sense organ2.091e-06Highly InformativeDirect
Fly Anatomy (FA)maxillary palpus2.214e-06Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)central nervous system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)brain0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.3312Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.5529Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.7213Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.377Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.002779InformativeInherited
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.00021Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.0002365Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)pedicel0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)leaf lamina0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)stalk0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)phyllome apex0Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.6768Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processPurine biosynthesis0InformativeDirect
Biological processCell shape1.376e-13InformativeDirect
Biological processNeurogenesis3.23e-05InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentCell membrane1Moderately InformativeInherited
Cellular componentCell inner membrane1.821e-05InformativeDirect
Developmental stageEarly protein1.02e-08Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0Moderately InformativeDirect
DomainHomeobox0Highly InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0.003214Least InformativeInherited
UniPathway (UP)NAD(+) biosynthesis2.783e-07InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR010982 SSF47413 Protein matches
Abstract

Bacteriophage lambda C1 repressor controls the expression of viral genes as part of the lysogeny/lytic growth switch. C1 is essential for maintaining lysogeny, where the phage replicates non-disruptively along with the host. If the host cell is threatened, then lytic growth is induced. The Lambda C1 repressor consists of two domains connected by a linker: an N-terminal DNA-binding domain that also mediates interactions with RNA polymerase, and a C-terminal dimerisation domain [PubMed10892750]. The DNA-binding domain consists of four helices in a closed folded leaf motif. Several different phage repressors from different helix-turn-helix families contain DNA-binding domains that adopt a similar topology. These include the Lambda Cro repressor, Bacteriophage 434 C1 and Cro repressors, P22 C2 repressor, and Bacteriophage Mu Ner protein.

The DNA-binding domain of Bacillus subtilis spore inhibition repressor SinR is identical to that of phage repressors [PubMed9799632]. SinR represses sporulation, which only occurs in response to adverse conditions. This provides a possible evolutionary link between the two adaptive responses of bacterial sporulation and prophage induction.

Other DNA-binding domains also display similar structural folds to that of Lambda C1. These include bacterial regulators such as the purine repressor (PurR), the lactose repressor (Lacr) and the fructose repressor (FruR), each of which has an N-terminal DNA-binding domain that exhibits a fold similar to that of lambda C1, except that they lack the first helix [PubMed7973627, PubMed10700279, PubMed9237914]. POU-specific domains found in transcription factors such as in Oct-1, Pit-1 and Hepatocyte nuclear factor 1a (LFB1/HNF1) display four-helical fold DNA-binding domains similar to that of Lambda C1 [PubMed11583619, PubMed9009203, PubMed12453420]. The N-terminal domain of cyanase has an alpha-helix bundle motif similar to Lambda C1, but it probably does not bind DNA. Cyanase is an enzyme found in bacteria and plants that catalyses the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide in response to extracellular cyanate [PubMed10801492].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a lambda repressor-like DNA-binding domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the lambda repressor-like DNA-binding domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]