SUPERFAMILY 1.75 HMM library and genome assignments server


lambda repressor-like DNA-binding domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   lambda repressor-like DNA-binding domains [ 47412]
Superfamily:   lambda repressor-like DNA-binding domains [ 47413] (13)
Families:   POU-specific domain [ 47414] (3)
  Phage repressors [ 47419] (7)
  SinR domain-like [ 47432] (8)
  Cyanase N-terminal domain [ 47435]
  GalR/LacI-like bacterial regulator [ 47438] (4)
  YdiL-like [ 109813] (2)
  CUT domain [ 116891] (4)
  Probable transcriptional regulator VC1968, N-terminal domain [ 116898]
  Bacteriophage CII protein [ 140520]
  NE0471 C-terminal domain-like [ 140523]
  PrgX N-terminal domain-like [ 140526]
  EDF1-like [ 140529]
  NE1354 [ 140532] (2)


Superfamily statistics
Genomes (2,907) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 60,132 174,175 80
Proteins 59,274 172,913 80


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)binding11.175e-05Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.0010690Moderately InformativeInherited
Molecular Function (MF)DNA binding1.393e-050InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity0.0001060InformativeDirect
Molecular Function (MF)sequence-specific DNA binding transcription factor activity9.598e-050Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1.099e-06 Least Informative Direct
Biological Process (BP) developmental process 7.913e-09 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.182e-06 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8231 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.9924 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.9573 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7457 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 7.5e-08 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 7.782e-13 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.295e-09 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 1.633e-06 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 1.955e-06 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 2.088e-06 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 4.869e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0003492 Moderately Informative Direct
Biological Process (BP) tissue development 0.0006831 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.1365 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.1065 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.5003 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.001048 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.6315 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.8508 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.005912 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9809 Moderately Informative Inherited
Biological Process (BP) system process 0.6283 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.005863 Moderately Informative Inherited
Biological Process (BP) gene expression 0.01796 Moderately Informative Inherited
Biological Process (BP) positive regulation of gene expression 6.809e-13 Informative Direct
Biological Process (BP) transcription, DNA-dependent 1.951e-11 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1.748e-08 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 4.052e-07 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1.093e-06 Informative Direct
Biological Process (BP) embryonic morphogenesis 2.914e-05 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0001394 Informative Direct
Biological Process (BP) cell-cell signaling 0.0001467 Informative Direct
Biological Process (BP) sensory organ development 0.0004198 Informative Direct
Biological Process (BP) negative regulation of cell death 0.5907 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.9241 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) epithelium development 0.4924 Informative Inherited
Biological Process (BP) organ morphogenesis 0.8057 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.3223 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.0403 Informative Inherited
Biological Process (BP) regulation of cell development 0.2102 Informative Inherited
Biological Process (BP) generation of neurons 0.1222 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.6204 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2935 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.3125 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.5596 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.4736 Informative Inherited
Biological Process (BP) cell activation 0.001593 Informative Inherited
Biological Process (BP) cell projection organization 0.001282 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.3553 Informative Inherited
Biological Process (BP) organelle assembly 0.1592 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3114 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.2408 Informative Inherited
Biological Process (BP) secretion by cell 0.005888 Informative Inherited
Biological Process (BP) gland development 0.6408 Informative Inherited
Biological Process (BP) central nervous system development 0.03965 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.03905 Informative Inherited
Biological Process (BP) single-organism behavior 0.4136 Informative Inherited
Biological Process (BP) chromosome organization 0.341 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.2137 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) endocrine system development 1.932e-15 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 3.175e-06 Highly Informative Direct
Biological Process (BP) renal system development 3.328e-06 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 2.047e-05 Highly Informative Direct
Biological Process (BP) hormone transport 2.663e-05 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 3.031e-05 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 4.073e-05 Highly Informative Direct
Biological Process (BP) inner ear development 4.315e-05 Highly Informative Direct
Biological Process (BP) cell fate commitment 4.437e-05 Highly Informative Direct
Biological Process (BP) diencephalon development 0.0001224 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0002003 Highly Informative Direct
Biological Process (BP) amide transport 0.0002214 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.04258 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00397 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.08295 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.01995 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.481 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.005669 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.6908 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.06972 Highly Informative Inherited
Biological Process (BP) signal release 0.07102 Highly Informative Inherited
Biological Process (BP) sensory perception 0.0262 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.5982 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.6569 Highly Informative Inherited
Molecular Function (MF) binding 1.175e-05 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) chromatin binding 3.158e-10 Informative Direct
Molecular Function (MF) protein dimerization activity 2.824e-05 Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 1.439e-09 Highly Informative Direct
Molecular Function (MF) transcription factor binding 1.062e-06 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.1854 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1137 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.00695 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1.597e-09 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.006158 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 1.394e-09 Informative Direct
Cellular Component (CC) chromosome 0.00159 Informative Inherited
Cellular Component (CC) transcription factor complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3558Least InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.0738Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.294Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.6003Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1224InformativeInherited
Mammalian Phenotype (MP)abnormal cerebrum morphology0.3863InformativeInherited
Mammalian Phenotype (MP)abnormal temporal bone morphology0.0004029Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cerebral cortex morphology0.2461Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism segment morphology variant0.004634Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant1.966e-05InformativeDirect
Worm Phenotype (WP)male tail morphology variant7.122e-07Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0.0006311Moderately InformativeDirect
Fly Phenotype (FP)sensory perception defective0.0002252InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.08611Least InformativeInherited
Fly Anatomy (FA)anatomical group0.09945Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1308Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)head0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.0004718Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0.01248Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01309Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.02084Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.02288Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.02299Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.0417Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05973Moderately InformativeInherited
Fly Anatomy (FA)appendage0.07466Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2219Moderately InformativeInherited
Fly Anatomy (FA)antennal segment2.529e-06InformativeDirect
Fly Anatomy (FA)synaptic neuropil domain3.692e-06InformativeDirect
Fly Anatomy (FA)chemosensory system4.529e-06InformativeDirect
Fly Anatomy (FA)adult external head9.555e-06InformativeDirect
Fly Anatomy (FA)adult central nervous system2.363e-05InformativeDirect
Fly Anatomy (FA)adult procephalic segment6.756e-05InformativeDirect
Fly Anatomy (FA)brain0.0002829InformativeDirect
Fly Anatomy (FA)ganglion0.006131InformativeInherited
Fly Anatomy (FA)appendage segment0.02576InformativeInherited
Fly Anatomy (FA)antennal lobe glomerulus VA1v2.544e-09Highly InformativeDirect
Fly Anatomy (FA)antennal lobe projection neuron iPN1.221e-06Highly InformativeDirect
Fly Anatomy (FA)mushroom body extrinsic neuron1.221e-06Highly InformativeDirect
Fly Anatomy (FA)eo neuron1.408e-06Highly InformativeDirect
Fly Anatomy (FA)uniglomerular antennal lobe projection neuron1.493e-06Highly InformativeDirect
Fly Anatomy (FA)maxillary palpus2.236e-06Highly InformativeDirect
Fly Anatomy (FA)antennal sense organ2.813e-06Highly InformativeDirect
Fly Anatomy (FA)neuroblast lineage clone2.988e-05Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)brain0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0.496Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.5256Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.9053Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.3871Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.0008484InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0004184Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.6922Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processPurine biosynthesis0InformativeDirect
Biological processCell shape1.204e-13InformativeDirect
Biological processNeurogenesis4.327e-05InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentCell membrane0.9657Moderately InformativeInherited
Cellular componentCell inner membrane1.982e-05InformativeDirect
Developmental stageEarly protein1.173e-08Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0InformativeDirect
DomainHomeobox0Highly InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010982 SSF47413 Protein matches
Abstract

Bacteriophage lambda C1 repressor controls the expression of viral genes as part of the lysogeny/lytic growth switch. C1 is essential for maintaining lysogeny, where the phage replicates non-disruptively along with the host. If the host cell is threatened, then lytic growth is induced. The Lambda C1 repressor consists of two domains connected by a linker: an N-terminal DNA-binding domain that also mediates interactions with RNA polymerase, and a C-terminal dimerisation domain [PubMed10892750]. The DNA-binding domain consists of four helices in a closed folded leaf motif. Several different phage repressors from different helix-turn-helix families contain DNA-binding domains that adopt a similar topology. These include the Lambda Cro repressor, Bacteriophage 434 C1 and Cro repressors, P22 C2 repressor, and Bacteriophage Mu Ner protein.

The DNA-binding domain of Bacillus subtilis spore inhibition repressor SinR is identical to that of phage repressors [PubMed9799632]. SinR represses sporulation, which only occurs in response to adverse conditions. This provides a possible evolutionary link between the two adaptive responses of bacterial sporulation and prophage induction.

Other DNA-binding domains also display similar structural folds to that of Lambda C1. These include bacterial regulators such as the purine repressor (PurR), the lactose repressor (Lacr) and the fructose repressor (FruR), each of which has an N-terminal DNA-binding domain that exhibits a fold similar to that of lambda C1, except that they lack the first helix [PubMed7973627, PubMed10700279, PubMed9237914]. POU-specific domains found in transcription factors such as in Oct-1, Pit-1 and Hepatocyte nuclear factor 1a (LFB1/HNF1) display four-helical fold DNA-binding domains similar to that of Lambda C1 [PubMed11583619, PubMed9009203, PubMed12453420]. The N-terminal domain of cyanase has an alpha-helix bundle motif similar to Lambda C1, but it probably does not bind DNA. Cyanase is an enzyme found in bacteria and plants that catalyses the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide in response to extracellular cyanate [PubMed10801492].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a lambda repressor-like DNA-binding domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the lambda repressor-like DNA-binding domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]