SUPERFAMILY 1.75 HMM library and genome assignments server


Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47390]
Superfamily:   Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47391]
Families:   Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47392] (2)


Superfamily statistics
Genomes (258) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,727 1,896 4
Proteins 1,717 1,888 4


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.0002237 Least Informative Direct
Biological Process (BP) multicellular organismal process 8.969e-07 Least Informative Direct
Biological Process (BP) developmental process 0.0009488 Least Informative Direct
Biological Process (BP) response to stimulus 0.01686 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3619 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02418 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.006764 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.001118 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.2052 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.7139 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.0002924 Moderately Informative Direct
Biological Process (BP) system process 0.0009102 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 3.383e-07 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 1.437e-09 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 1.776e-09 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.003813 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.087 Moderately Informative Inherited
Biological Process (BP) organ development 0.4834 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.0163 Moderately Informative Inherited
Biological Process (BP) tissue development 0.02939 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.06966 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1541 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.03887 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.03544 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.0409 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.04106 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.04023 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.07574 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1309 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.02026 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.002358 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) cytoskeleton organization 4.975e-06 Informative Direct
Biological Process (BP) microtubule-based process 0.0007188 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.0006803 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 2.771e-05 Informative Direct
Biological Process (BP) organ morphogenesis 2.764e-05 Informative Direct
Biological Process (BP) response to organonitrogen compound 7.856e-05 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) sexual reproduction 0.0001571 Informative Direct
Biological Process (BP) actin filament-based process 2.439e-06 Informative Direct
Biological Process (BP) single organism reproductive process 2.569e-05 Informative Direct
Biological Process (BP) single-organism behavior 1.112e-11 Informative Direct
Biological Process (BP) cellular process involved in reproduction 6.313e-06 Informative Direct
Biological Process (BP) organelle assembly 0.0001435 Informative Direct
Biological Process (BP) cardiovascular system development 0.03864 Informative Inherited
Biological Process (BP) muscle tissue development 0.02829 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.09861 Informative Inherited
Biological Process (BP) cell projection organization 0.006312 Informative Inherited
Biological Process (BP) growth 0.003058 Informative Inherited
Biological Process (BP) muscle structure development 0.03015 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1041 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.04957 Informative Inherited
Biological Process (BP) epithelium development 0.4287 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.001854 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.138 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1114 Informative Inherited
Biological Process (BP) epithelial cell development 0.00018 Highly Informative Direct
Biological Process (BP) protein phosphorylation 6.506e-05 Highly Informative Direct
Biological Process (BP) spermatogenesis 5.219e-09 Highly Informative Direct
Biological Process (BP) learning or memory 0.0002461 Highly Informative Direct
Biological Process (BP) nucleoside diphosphate metabolic process 1.037e-10 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0002705 Highly Informative Direct
Biological Process (BP) developmental maturation 0.000525 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0009965 Highly Informative Direct
Biological Process (BP) cilium organization 6.364e-07 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 8.859e-07 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.02209 Highly Informative Inherited
Molecular Function (MF) binding 0.6364 Least Informative Inherited
Molecular Function (MF) transferase activity 0.2745 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.02712 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 2.098e-07 Informative Direct
Molecular Function (MF) kinase activity 0.0125 Informative Inherited
Molecular Function (MF) nucleobase-containing compound kinase activity 6.502e-08 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0003999 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.04471 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9176 Least Informative Inherited
Cellular Component (CC) cell projection 2.073e-05 Moderately Informative Direct
Cellular Component (CC) cilium part 1.64e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0InformativeDirect
Enzyme Commission (EC)Adenylate kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane4.602e-08Least InformativeDirect
Cellular componentCytoplasm0.2632Least InformativeInherited
Cellular componentCytoskeleton2.623e-08Moderately InformativeDirect
Cellular componentCell projection6.701e-08Moderately InformativeDirect
Cellular componentCilium1.231e-11Highly InformativeDirect
DomainRepeat1.226e-15Least InformativeDirect
Molecular functionNucleotide-binding1.075e-08Least InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncAMP-binding0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation1.359e-05Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003117 SSF47391 Protein matches
Abstract

In the absence of cAMP, Protein Kinase A (PKA) exists as an equimolar tetramer of regulatory (R) and catalytic (C) subunits [PubMed11734894]. In addition to its role as an inhibitor of the C subunit, the R subunit anchors the holoenzyme to specific intracellular locations and prevents the C subunit from entering the nucleus. All R subunits have a conserved domain structure consisting of the N-terminal dimerization domain, inhibitory region, cAMP-binding domain A and cAMP-binding domain B. R subunits interact with C subunits primarily through the inhibitory site. The cAMP-binding domains show extensive sequence similarity and bind cAMP cooperatively.

Two types of R subunit exist - Type I and Type II - which differ in molecular weight, sequence, autophosphorylation cabaility, cellular location and tissue distribution. Types I and II were further sub-divided into alpha and beta subtypes, based mainly on sequence similarity. This family of RII alpha, the regulatory subunit portion of type II PKA proteins, contains the dimerisation interface and binding site for A-kinase-anchoring proteins (AKAPs).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]