SUPERFAMILY 1.75 HMM library and genome assignments server

Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47390]
Superfamily:   Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47391]
Families:   Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47392] (2)


Superfamily statistics
Genomes (259) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,750 1,896 4
Proteins 1,740 1,888 4


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000001603 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0003782 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.09087 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.001064 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.0164 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.1774 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.001103 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.009526 Least Informative Inherited
Biological Process (BP) response to stimulus 0.0204 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000000000002422 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000000001138 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.000000004742 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000004007 Moderately Informative Direct
Biological Process (BP) reproductive process 0.0003589 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.08931 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.4561 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.005205 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01619 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.007216 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.001697 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1538 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1902 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.04039 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.04045 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.04983 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.04994 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.08226 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.002832 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.143 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0493 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transferase activity 0 Informative Direct
Biological Process (BP) cell proliferation 0.00000000003849 Informative Direct
Biological Process (BP) single-organism behavior 0.0000000001165 Informative Direct
Biological Process (BP) neurological system process 0.00000001663 Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.000001717 Informative Direct
Biological Process (BP) organ morphogenesis 0.000004041 Informative Direct
Biological Process (BP) actin filament-based process 0.000005518 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.00003328 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.00007398 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0001787 Informative Direct
Biological Process (BP) organelle assembly 0.000806 Informative Direct
Biological Process (BP) cardiovascular system development 0.03956 Informative Inherited
Biological Process (BP) growth 0.0035 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.001046 Informative Inherited
Biological Process (BP) muscle structure development 0.01425 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.199 Informative Inherited
Biological Process (BP) cell projection organization 0.00889 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.001069 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.001187 Informative Inherited
Biological Process (BP) sexual reproduction 0.006913 Informative Inherited
Biological Process (BP) single organism reproductive process 0.001089 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.05518 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.05553 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1433 Informative Inherited
Biological Process (BP) nucleoside diphosphate metabolic process 0.000000000125 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.000000006398 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 0.0000009524 Highly Informative Direct
Biological Process (BP) cilium organization 0.000001872 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.00002872 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.000116 Highly Informative Direct
Biological Process (BP) germ cell development 0.0005062 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.02043 Highly Informative Inherited
Molecular Function (MF) binding 0.6957 Least Informative Inherited
Molecular Function (MF) transferase activity 0.3939 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0288 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 0.0000002518 Informative Direct
Molecular Function (MF) kinase activity 0.01306 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0.00000007663 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0003889 Highly Informative Direct
Cellular Component (CC) protein complex 0.0455 Least Informative Inherited
Cellular Component (CC) transferase complex 0.000000003865 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00003442 Moderately Informative Direct
Cellular Component (CC) synapse 0.003549 Informative Inherited
Cellular Component (CC) ciliary part 0.00000001783 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0InformativeDirect
Enzyme Commission (EC)Adenylate kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0.00000004728Least InformativeDirect
Cellular componentCytoplasm0.2626Least InformativeInherited
Cellular componentCytoskeleton0.00000002664Moderately InformativeDirect
Cellular componentCell projection0.00000006986Moderately InformativeDirect
Cellular componentCilium0.00000000001227Highly InformativeDirect
DomainRepeat0.000000000000001223Least InformativeDirect
Molecular functionNucleotide-binding0.00000001068Least InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncAMP-binding0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00001365Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003117 SSF47391 Protein matches
Abstract

In the absence of cAMP, Protein Kinase A (PKA) exists as an equimolar tetramer of regulatory (R) and catalytic (C) subunits [PubMed11734894]. In addition to its role as an inhibitor of the C subunit, the R subunit anchors the holoenzyme to specific intracellular locations and prevents the C subunit from entering the nucleus. All R subunits have a conserved domain structure consisting of the N-terminal dimerization domain, inhibitory region, cAMP-binding domain A and cAMP-binding domain B. R subunits interact with C subunits primarily through the inhibitory site. The cAMP-binding domains show extensive sequence similarity and bind cAMP cooperatively.

Two types of R subunit exist - Type I and Type II - which differ in molecular weight, sequence, autophosphorylation cabaility, cellular location and tissue distribution. Types I and II were further sub-divided into alpha and beta subtypes, based mainly on sequence similarity. This family of RII alpha, the regulatory subunit portion of type II PKA proteins, contains the dimerisation interface and binding site for A-kinase-anchoring proteins (AKAPs).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]