SUPERFAMILY 1.75 HMM library and genome assignments server


Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47390]
Superfamily:   Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47391]
Families:   Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47392] (2)


Superfamily statistics
Genomes (252) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,644 1,896 4
Proteins 1,634 1,888 4


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0000005422 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0002362 Least Informative Direct
Biological Process (BP) developmental process 0.0006836 Least Informative Direct
Biological Process (BP) response to stimulus 0.01255 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.359 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01905 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.003906 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.001128 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.207 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.7154 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0000000007628 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000000001959 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000002118 Moderately Informative Direct
Biological Process (BP) reproduction 0.0002349 Moderately Informative Direct
Biological Process (BP) system process 0.0008921 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.003681 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.08522 Moderately Informative Inherited
Biological Process (BP) organ development 0.4832 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01597 Moderately Informative Inherited
Biological Process (BP) tissue development 0.02863 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.0691 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.155 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.02687 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.03486 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0351 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.0359 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.03607 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.067 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1324 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.01755 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.001571 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.002779 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) single-organism behavior 0.000000000006006 Informative Direct
Biological Process (BP) actin filament-based process 0.000002239 Informative Direct
Biological Process (BP) cytoskeleton organization 0.000003265 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.000006327 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.00002297 Informative Direct
Biological Process (BP) single organism reproductive process 0.00002471 Informative Direct
Biological Process (BP) organ morphogenesis 0.00002871 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.00008339 Informative Direct
Biological Process (BP) organelle assembly 0.0001047 Informative Direct
Biological Process (BP) sexual reproduction 0.0001563 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.0005959 Informative Direct
Biological Process (BP) microtubule-based process 0.0006648 Informative Direct
Biological Process (BP) cardiovascular system development 0.03941 Informative Inherited
Biological Process (BP) muscle tissue development 0.0279 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.09943 Informative Inherited
Biological Process (BP) cell projection organization 0.006158 Informative Inherited
Biological Process (BP) growth 0.001357 Informative Inherited
Biological Process (BP) muscle structure development 0.02923 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.103 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.04769 Informative Inherited
Biological Process (BP) epithelium development 0.4398 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.001877 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1336 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1089 Informative Inherited
Biological Process (BP) nucleoside diphosphate metabolic process 0.0000000000858 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.000000003691 Highly Informative Direct
Biological Process (BP) cilium organization 0.0000006065 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 0.0000007323 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.00006379 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.0001906 Highly Informative Direct
Biological Process (BP) learning or memory 0.0002245 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0002445 Highly Informative Direct
Biological Process (BP) developmental maturation 0.0005132 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0009649 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.02011 Highly Informative Inherited
Molecular Function (MF) binding 0.5683 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.02298 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 0.0000001689 Informative Direct
Molecular Function (MF) kinase activity 0.01051 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0.00000006307 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0003721 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.03525 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9331 Least Informative Inherited
Cellular Component (CC) cell projection 0.0004319 Moderately Informative Direct
Cellular Component (CC) neuromuscular junction 0.00000005595 Highly Informative Direct
Cellular Component (CC) cilium part 0.000001632 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0InformativeDirect
Enzyme Commission (EC)Adenylate kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0.0000000446Least InformativeDirect
Cellular componentCytoplasm0.2641Least InformativeInherited
Cellular componentCytoskeleton0.00000002631Moderately InformativeDirect
Cellular componentCell projection0.00000006746Moderately InformativeDirect
Cellular componentCilium0.00000000001245Highly InformativeDirect
DomainRepeat0.000000000000001221Least InformativeDirect
Molecular functionNucleotide-binding0.00000001081Least InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncAMP-binding0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00001273Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003117 SSF47391 Protein matches
Abstract

In the absence of cAMP, Protein Kinase A (PKA) exists as an equimolar tetramer of regulatory (R) and catalytic (C) subunits [PubMed11734894]. In addition to its role as an inhibitor of the C subunit, the R subunit anchors the holoenzyme to specific intracellular locations and prevents the C subunit from entering the nucleus. All R subunits have a conserved domain structure consisting of the N-terminal dimerization domain, inhibitory region, cAMP-binding domain A and cAMP-binding domain B. R subunits interact with C subunits primarily through the inhibitory site. The cAMP-binding domains show extensive sequence similarity and bind cAMP cooperatively.

Two types of R subunit exist - Type I and Type II - which differ in molecular weight, sequence, autophosphorylation cabaility, cellular location and tissue distribution. Types I and II were further sub-divided into alpha and beta subtypes, based mainly on sequence similarity. This family of RII alpha, the regulatory subunit portion of type II PKA proteins, contains the dimerisation interface and binding site for A-kinase-anchoring proteins (AKAPs).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]