SUPERFAMILY 1.75 HMM library and genome assignments server


Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47390]
Superfamily:   Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47391]
Families:   Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47392] (2)


Superfamily statistics
Genomes (228) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 1,578 1,415 4
Proteins 1,569 1,407 4


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 6.158e-05 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.128e-05 Least Informative Direct
Biological Process (BP) response to stimulus 0.007714 Least Informative Inherited
Biological Process (BP) developmental process 0.00227 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3726 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1859 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.2163 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2995 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.01039 Least Informative Inherited
Biological Process (BP) system process 0.0008108 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 1.03e-07 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 5.592e-08 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0009083 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0006688 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 2.674e-07 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 1.287e-06 Moderately Informative Direct
Biological Process (BP) organ development 0.1192 Moderately Informative Inherited
Biological Process (BP) tissue development 0.163 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.02457 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.06066 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.03232 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.02868 Moderately Informative Inherited
Biological Process (BP) reproduction 0.006805 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.1983 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 5.708e-11 Informative Direct
Biological Process (BP) protein phosphorylation 3.528e-08 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0009813 Informative Direct
Biological Process (BP) cell proliferation 1.086e-13 Informative Direct
Biological Process (BP) organ morphogenesis 9.771e-07 Informative Direct
Biological Process (BP) response to organic nitrogen 6.569e-05 Informative Direct
Biological Process (BP) actin filament-based process 0.0002593 Informative Direct
Biological Process (BP) regulation of kinase activity 1.732e-12 Informative Direct
Biological Process (BP) single organism reproductive process 0.0005215 Informative Direct
Biological Process (BP) single-organism behavior 4.46e-12 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.000127 Informative Direct
Biological Process (BP) cardiovascular system development 0.05608 Informative Inherited
Biological Process (BP) muscle tissue development 0.006289 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.07773 Informative Inherited
Biological Process (BP) growth 0.002331 Informative Inherited
Biological Process (BP) muscle structure development 0.02129 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.03692 Informative Inherited
Biological Process (BP) sexual reproduction 0.001055 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.008495 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1073 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.09159 Informative Inherited
Biological Process (BP) spermatogenesis 7.624e-06 Highly Informative Direct
Biological Process (BP) gastrulation 9.645e-06 Highly Informative Direct
Biological Process (BP) learning or memory 0.0002212 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.000127 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.0004339 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 1.031e-06 Highly Informative Direct
Molecular Function (MF) binding 0.8631 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.017 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 5.611e-07 Informative Direct
Molecular Function (MF) protein kinase regulator activity 0 Highly Informative Direct
Cellular Component (CC) protein complex 0.07022 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.0332 Moderately Informative Inherited
Cellular Component (CC) synapse 0.001036 Informative Inherited
Cellular Component (CC) neuromuscular junction 7.675e-08 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0InformativeDirect
Enzyme Commission (EC)Adenylate kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane7.932e-07Least InformativeDirect
Cellular componentCytoplasm0.5467Least InformativeInherited
Cellular componentCell projection1.323e-08Moderately InformativeDirect
Cellular componentCytoskeleton1.141e-05Moderately InformativeDirect
Cellular componentCilium4.661e-12Highly InformativeDirect
DomainRepeat3.221e-16Least InformativeDirect
Molecular functionNucleotide-binding3.716e-09Least InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation1.418e-07Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003117 SSF47391 Protein matches
Abstract

In the absence of cAMP, Protein Kinase A (PKA) exists as an equimolar tetramer of regulatory (R) and catalytic (C) subunits [PubMed11734894]. In addition to its role as an inhibitor of the C subunit, the R subunit anchors the holoenzyme to specific intracellular locations and prevents the C subunit from entering the nucleus. All R subunits have a conserved domain structure consisting of the N-terminal dimerization domain, inhibitory region, cAMP-binding domain A and cAMP-binding domain B. R subunits interact with C subunits primarily through the inhibitory site. The cAMP-binding domains show extensive sequence similarity and bind cAMP cooperatively.

Two types of R subunit exist - Type I and Type II - which differ in molecular weight, sequence, autophosphorylation cabaility, cellular location and tissue distribution. Types I and II were further sub-divided into alpha and beta subtypes, based mainly on sequence similarity. This family of RII alpha, the regulatory subunit portion of type II PKA proteins, contains the dimerisation interface and binding site for A-kinase-anchoring proteins (AKAPs).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]