SUPERFAMILY 1.75 HMM library and genome assignments server

Homodimeric domain of signal transducing histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   ROP-like [ 47379] (8)
Superfamily:   Homodimeric domain of signal transducing histidine kinase [ 47384]
Families:   Homodimeric domain of signal transducing histidine kinase [ 47385] (3)


Superfamily statistics
Genomes (2,842) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 56,093 291,179 3
Proteins 55,918 290,755 3


Functional annotation
General category coiled coil
Detailed category The code refers to a Dimeric_canonical_parallel_coiled_coils in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0.000000000001456 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0000000006908 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0003675 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.9232 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.0595 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.7607 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.338 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.2523 Moderately Informative Inherited
Biological Process (BP) organ development 0.9564 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.0447 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.6992 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3067 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) response to nutrient levels 0.000371 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0007987 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.03493 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.09847 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.008149 Informative Inherited
Biological Process (BP) reproductive structure development 0.003176 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.03381 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.01287 Informative Inherited
Biological Process (BP) response to cytokinin 0.00000005062 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0000137 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.000114 Highly Informative Direct
Biological Process (BP) response to alcohol 0.0001514 Highly Informative Direct
Biological Process (BP) pathogenesis 0.000281 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.2228 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.2569 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.01416 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphatase activity 0.00001664 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00009211 Informative Direct
Molecular Function (MF) protein kinase activity 0.0000000324 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0.03767 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.000003534 Moderately Informative Direct
Cellular Component (CC) integral component of membrane 0.00001508 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)fruit0.000004549InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage0.00000001957InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processNitrogen fixation0.000000000000003691InformativeDirect
Biological processSensory transduction0.000000001611InformativeDirect
Biological processChemotaxis0.0000001057InformativeDirect
Biological processSporulation0.0000008617InformativeDirect
Biological processAntibiotic resistance0.00000512InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processEthylene signaling pathway0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00000118Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCopper0.000000000000001378InformativeDirect
Molecular functionChromophore0.0000000006686InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0.0000000000007207Moderately InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationTransducer0.0008632InformativeDirect
Post-translational modificationPhotoreceptor protein0.0000000001342Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009082 SSF47384 Protein matches
Abstract

Signal transducing histidine kinases are the key elements in two-component signal transduction systems, which control complex processes such as the initiation of development in microorganisms [PubMed8868347]. Examples of histidine kinases are EnvZ, which plays a central role in osmoregulation [PubMed10426948], and CheA, which plays a central role in the chemotaxis system [PubMed9989504]. Histidine kinases usually have an N-terminal ligand-binding domain and a C-terminal kinase domain, but other domains may also be present. The kinase domain is responsible for the autophosphorylation of the histidine with ATP, the phosphotransfer from the kinase to an aspartate of the response regulator, and the phosphotransfer from aspartyl phosphate back to ADP or to water [PubMed11145881]. The homodimeric domain includes the site of histidine autophosphorylation and phosphate transfer reactions. The structure of the homodimeric domain comprises a closed, four-helical bundle with a left-handed twist, formed by two identical alpha-hairpin subunits.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Homodimeric domain of signal transducing histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Homodimeric domain of signal transducing histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]