SUPERFAMILY 1.75 HMM library and genome assignments server


Homodimeric domain of signal transducing histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   ROP-like [ 47379] (8)
Superfamily:   Homodimeric domain of signal transducing histidine kinase [ 47384]
Families:   Homodimeric domain of signal transducing histidine kinase [ 47385] (3)


Superfamily statistics
Genomes (2,840) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 56,014 291,179 3
Proteins 55,840 290,755 3


Functional annotation
General category coiled coil
Detailed category The code refers to a Dimeric_canonical_parallel_coiled_coils in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) protein metabolic process 3.594e-12 Least Informative Direct
Biological Process (BP) single-organism cellular process 8.649e-12 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.04486 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.3862 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1242 Moderately Informative Inherited
Biological Process (BP) organ development 0.8656 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.6426 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.629 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.06362 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2552 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) response to nutrient levels 0.0001252 Informative Direct
Biological Process (BP) reproductive system development 0.0006273 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.01287 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.01029 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01426 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01482 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.04468 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.001712 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.06528 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.01689 Informative Inherited
Biological Process (BP) cellular response to alcohol 1.373e-05 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0004009 Highly Informative Direct
Biological Process (BP) pathogenesis 0.0006281 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.2355 Highly Informative Inherited
Molecular Function (MF) binding 0.23 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.05236 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 3.957e-05 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0.001456 Informative Inherited
Molecular Function (MF) protein kinase activity 9.751e-09 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 2.585e-06 Highly Informative Direct
Cellular Component (CC) membrane 0.04223 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 8.304e-06 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)fruit4.549e-06InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage1.957e-08InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processNitrogen fixation3.23e-15InformativeDirect
Biological processSensory transduction1.323e-09InformativeDirect
Biological processChemotaxis9.753e-08InformativeDirect
Biological processSporulation8.111e-07InformativeDirect
Biological processAntibiotic resistance4.206e-06InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processEthylene signaling pathway0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum8.964e-07Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCopper1.383e-15InformativeDirect
Molecular functionChromophore6.169e-10InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor5.851e-13Moderately InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationTransducer0.0008077InformativeDirect
Post-translational modificationPhotoreceptor protein1.349e-10Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009082 SSF47384 Protein matches
Abstract

Signal transducing histidine kinases are the key elements in two-component signal transduction systems, which control complex processes such as the initiation of development in microorganisms [PubMed8868347]. Examples of histidine kinases are EnvZ, which plays a central role in osmoregulation [PubMed10426948], and CheA, which plays a central role in the chemotaxis system [PubMed9989504]. Histidine kinases usually have an N-terminal ligand-binding domain and a C-terminal kinase domain, but other domains may also be present. The kinase domain is responsible for the autophosphorylation of the histidine with ATP, the phosphotransfer from the kinase to an aspartate of the response regulator, and the phosphotransfer from aspartyl phosphate back to ADP or to water [PubMed11145881]. The homodimeric domain includes the site of histidine autophosphorylation and phosphate transfer reactions. The structure of the homodimeric domain comprises a closed, four-helical bundle with a left-handed twist, formed by two identical alpha-hairpin subunits.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Homodimeric domain of signal transducing histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Homodimeric domain of signal transducing histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]