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Bromodomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Bromodomain [ 47370]
Families:   Bromodomain [ 47371] (4)


Superfamily statistics
Genomes (495) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 13,400 14,142 8
Proteins 10,507 10,963 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000000001253 Least Informative Direct
Biological Process (BP) developmental process 0.000000002642 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0000004226 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000004431 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0001665 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0003252 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.001141 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.002383 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.001668 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.000000000000001938 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0000000000001364 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.000000001681 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000000265 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00008916 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0001888 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.2561 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.05545 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.02572 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.104 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.006121 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.03513 Moderately Informative Inherited
Biological Process (BP) immune system process 0.5124 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.04356 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.0498 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.05611 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.1445 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.5216 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.527 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.9186 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01725 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.07183 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.9199 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.6498 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.7492 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0.0000000002337 Informative Direct
Biological Process (BP) DNA metabolic process 0.000000015 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.00000123 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.000001789 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00000517 Informative Direct
Biological Process (BP) cardiovascular system development 0.000006792 Informative Direct
Biological Process (BP) muscle structure development 0.00001605 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.00002328 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00007111 Informative Direct
Biological Process (BP) growth 0.0001249 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0001393 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.0001449 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.0002671 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.3433 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.1075 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.07303 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.2836 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001529 Informative Inherited
Biological Process (BP) tube development 0.2167 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5931 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.09844 Informative Inherited
Biological Process (BP) cell cycle process 0.1254 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.03206 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.346 Informative Inherited
Biological Process (BP) central nervous system development 0.9141 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.09321 Informative Inherited
Biological Process (BP) cell projection organization 0.2983 Informative Inherited
Biological Process (BP) generation of neurons 0.8554 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.02859 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1662 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.007311 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.006798 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.7178 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.00305 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.03472 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.004469 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.001782 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.08918 Informative Inherited
Biological Process (BP) epithelium development 0.6149 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.05839 Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) placenta development 0.00000000000002793 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0000000008065 Highly Informative Direct
Biological Process (BP) epithelial tube formation 0.000001646 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.00001666 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.00002117 Highly Informative Direct
Biological Process (BP) erythrocyte differentiation 0.0000253 Highly Informative Direct
Biological Process (BP) neural tube development 0.00005941 Highly Informative Direct
Biological Process (BP) gene silencing 0.00007556 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0.00008084 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0002001 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.0002604 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.0005624 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.000617 Highly Informative Direct
Biological Process (BP) protein deacylation 0.0006302 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0008187 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.0008522 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.000975 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.1338 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.01654 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.3792 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.1554 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.2884 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.4935 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.001032 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.02698 Highly Informative Inherited
Biological Process (BP) DNA modification 0.01532 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 0.003056 Highly Informative Inherited
Biological Process (BP) protein methylation 0.3683 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.005403 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.4049 Highly Informative Inherited
Biological Process (BP) meiosis 0.002313 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.00158 Highly Informative Inherited
Biological Process (BP) developmental growth 0.007845 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.0000003931 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.00000000000002118 Moderately Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) DNA binding 0.0000001033 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.0006856 Informative Direct
Molecular Function (MF) receptor binding 0.6763 Informative Inherited
Molecular Function (MF) acetyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000000000000001562 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.0000003207 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000000002664 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.00000000000344 Least Informative Direct
Cellular Component (CC) protein complex 0.000000007257 Least Informative Direct
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0000000002168 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.226 Informative Inherited
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 0.5877 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.107 Informative Inherited
Cellular Component (CC) kinetochore 0.0000000001397 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.00000108 Highly Informative Direct
Cellular Component (CC) spindle 0.6539 Highly Informative Inherited
Cellular Component (CC) chromatin 0.1695 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.7336Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.01673Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000006826InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)viral infectious disease0.5296InformativeInherited
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0006393Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.133Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.1512Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5926Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.01624Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.04762Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.1736Moderately InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0.2326Moderately InformativeInherited
Phenotypic Abnormality (PA)Short digit0.0008602InformativeDirect
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.003459InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eyelid0.0163InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hair0.02047InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.0977InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental delay0.2394InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eyelashes0.00001152Highly InformativeDirect
Phenotypic Abnormality (PA)Short phalanx of finger0.00002183Highly InformativeDirect
Phenotypic Abnormality (PA)Clubbing of toes0.00002274Highly InformativeDirect
Phenotypic Abnormality (PA)Delayed speech and language development0.0004872Highly InformativeDirect
Phenotypic Abnormality (PA)Hypertrichosis0.0009191Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.6142Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.01398Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.6443Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.08103InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.1905InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.000168Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.007523Least InformativeInherited
Worm Phenotype (WP)growth variant0.733Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.000001098Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0004989Moderately InformativeDirect
Worm Phenotype (WP)VPC competence variant0.000001002InformativeDirect
Worm Phenotype (WP)organism stress response variant0.000002911InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.000006808InformativeDirect
Worm Phenotype (WP)sick0.0009244InformativeDirect
Worm Phenotype (WP)vulva development variant0.02239InformativeInherited
Worm Phenotype (WP)organism UV hypersensitive0.000000000896Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0.09579Least InformativeInherited
Yeast Phenotype (YP)chromosome/plasmid maintenance0.00002956InformativeDirect
Yeast Phenotype (YP)chemical compound accumulation0.0009253InformativeDirect
Yeast Phenotype (YP)lifespan0.2187InformativeInherited
Yeast Phenotype (YP)ionic stress resistance0.0005717Highly InformativeDirect
Yeast Phenotype (YP)chronological lifespan0.0007084Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation0.0002562InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.01253Moderately InformativeInherited
Fly Anatomy (FA)cuticular specialization0.0008217InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.0001982Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.8297Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases4.839e-16Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.001404Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.007132Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.7285Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000005465InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0000002778InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0001669InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.04083InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0000000025Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.0000000009437Moderately InformativeDirect
Biological processCell cycle0.00004064Moderately InformativeDirect
Biological processHost-virus interaction0.0001336Moderately InformativeDirect
Biological processDifferentiation0.0001674Moderately InformativeDirect
Biological processBiological rhythms0.0000000006852InformativeDirect
Biological processMeiosis0.0000001278InformativeDirect
Biological processSporulation0.0000008335InformativeDirect
Biological processNeurogenesis0.000002652InformativeDirect
Biological processSpermatogenesis0.00001276Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0.0000007833InformativeDirect
Coding sequence diversityAlternative splicing0.000007894Least InformativeDirect
Coding sequence diversityChromosomal rearrangement0.000000007385InformativeDirect
DiseaseTumor suppressor0.0000002406Moderately InformativeDirect
DomainRepeat0.00008522Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.000000001306Moderately InformativeDirect
DomainBromodomain0Highly InformativeDirect
Molecular functionZinc0.0000000000001423Least InformativeDirect
Molecular functionDNA-binding0.00000008012Least InformativeDirect
Post-translational modificationTransferase0.6378Least InformativeInherited
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor0.0000000006702Moderately InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationAcyltransferase0.0000000000001193InformativeDirect
Post-translational modificationHelicase0.0000002049InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.000009358Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.00001204Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001487 SSF47370 Protein matches
Abstract Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [PubMed1350857]. Bromodomains can interact with acetylated lysine [PubMed9175470]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [PubMed7580139].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bromodomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Bromodomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]