ACP-like superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	All alpha proteins [ 46456] (284)
Fold:	Acyl carrier protein-like [ 47335] (3)
Superfamily:	ACP-like [ 47336] (3)
Families:	Acyl-carrier protein (ACP) [ 47337] (6)
	Peptidyl carrier domain [ 47342]
	apo-D-alanyl carrier protein [ 63535]

Superfamily statistics

	Genomes (2,304)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	25,376	65,552	17
Proteins	17,050	47,119	17

Functional annotation

General category	Other
Detailed category	Unknown function

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)

	GO term	FDR (singleton)	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	biosynthetic process	0.003954	0	Least Informative	Inherited
Biological Process (BP)	single-organism metabolic process	0.00422	0	Least Informative	Inherited
Biological Process (BP)	lipid biosynthetic process	5.682e-06	3.584e-08	Moderately Informative	Direct
Biological Process (BP)	monocarboxylic acid metabolic process	1.352e-09	0.0003775	Moderately Informative	Direct
Biological Process (BP)	cellular lipid metabolic process	6.905e-08	1.969e-10	Moderately Informative	Direct
Biological Process (BP)	small molecule biosynthetic process	0.0004448	0.0001303	Moderately Informative	Direct
Biological Process (BP)	fatty acid metabolic process	2.318e-12	0	Informative	Direct
Biological Process (BP)	monocarboxylic acid biosynthetic process	0.0001579	2.996e-07	Informative	Direct
Molecular Function (MF)	binding	0.00987	1	Least Informative	Inherited
Molecular Function (MF)	cofactor binding	4.538e-14	0	Informative	Direct

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	biosynthetic process	0	Least Informative	Direct
Biological Process (BP)	single-organism metabolic process	0	Least Informative	Direct
Biological Process (BP)	nitrogen compound metabolic process	0.5138	Least Informative	Inherited
Biological Process (BP)	cellular component organization or biogenesis	1	Least Informative	Inherited
Biological Process (BP)	single-organism cellular process	1	Least Informative	Inherited
Biological Process (BP)	multicellular organismal process	1	Least Informative	Inherited
Biological Process (BP)	developmental process	1	Least Informative	Inherited
Biological Process (BP)	cellular aromatic compound metabolic process	1	Least Informative	Inherited
Biological Process (BP)	organic cyclic compound metabolic process	1	Least Informative	Inherited
Biological Process (BP)	lipid biosynthetic process	3.584e-08	Moderately Informative	Direct
Biological Process (BP)	monocarboxylic acid metabolic process	0.0003775	Moderately Informative	Direct
Biological Process (BP)	cellular lipid metabolic process	1.969e-10	Moderately Informative	Direct
Biological Process (BP)	cellular nitrogen compound biosynthetic process	0.0001755	Moderately Informative	Direct
Biological Process (BP)	small molecule biosynthetic process	0.0001303	Moderately Informative	Direct
Biological Process (BP)	cofactor metabolic process	1.967e-10	Moderately Informative	Direct
Biological Process (BP)	organonitrogen compound biosynthetic process	0.0001209	Moderately Informative	Direct
Biological Process (BP)	organic hydroxy compound metabolic process	1.917e-06	Moderately Informative	Direct
Biological Process (BP)	aromatic compound biosynthetic process	0.4577	Moderately Informative	Inherited
Biological Process (BP)	organic cyclic compound biosynthetic process	0.8993	Moderately Informative	Inherited
Biological Process (BP)	cellular amino acid metabolic process	0.01544	Moderately Informative	Inherited
Biological Process (BP)	cellular component biogenesis	0.002333	Moderately Informative	Inherited
Biological Process (BP)	single-organism developmental process	1	Moderately Informative	Inherited
Biological Process (BP)	fatty acid metabolic process	0	Informative	Direct
Biological Process (BP)	cellular amide metabolic process	0	Informative	Direct
Biological Process (BP)	monocarboxylic acid biosynthetic process	2.996e-07	Informative	Direct
Biological Process (BP)	organic hydroxy compound biosynthetic process	0.0002661	Informative	Direct
Biological Process (BP)	alcohol metabolic process	0.3309	Informative	Inherited
Biological Process (BP)	phenol-containing compound metabolic process	0	Highly Informative	Direct
Biological Process (BP)	nonribosomal peptide biosynthetic process	0	Highly Informative	Direct
Biological Process (BP)	polyol metabolic process	2.68e-08	Highly Informative	Direct
Biological Process (BP)	diol metabolic process	0	Highly Informative	Direct
Biological Process (BP)	cell wall biogenesis	0	Highly Informative	Direct
Biological Process (BP)	secondary metabolite biosynthetic process	9.23e-13	Highly Informative	Direct
Biological Process (BP)	alcohol biosynthetic process	0.3725	Highly Informative	Inherited
Molecular Function (MF)	binding	1	Least Informative	Inherited
Molecular Function (MF)	transferase activity	0.6375	Least Informative	Inherited
Molecular Function (MF)	anion binding	0.02273	Moderately Informative	Inherited
Molecular Function (MF)	oxidoreductase activity	0.1483	Moderately Informative	Inherited
Molecular Function (MF)	transferase activity, transferring acyl groups	1.982e-05	Informative	Direct
Molecular Function (MF)	carboxylic acid binding	3.32e-06	Informative	Direct
Molecular Function (MF)	cofactor binding	0	Informative	Direct
Molecular Function (MF)	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3.079e-05	Highly Informative	Direct
Molecular Function (MF)	modified amino acid binding	1.142e-07	Highly Informative	Direct
Cellular Component (CC)	protein complex	0.7717	Least Informative	Inherited
Cellular Component (CC)	cytoplasmic part	0.001324	Least Informative	Inherited
Cellular Component (CC)	intracellular membrane-bounded organelle	1	Least Informative	Inherited
Cellular Component (CC)	external encapsulating structure	1.413e-06	Informative	Direct
Cellular Component (CC)	cell wall	1.714e-07	Highly Informative	Direct
Cellular Component (CC)	lipid particle	0.0005417	Highly Informative	Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Ligases	0	Least Informative	Direct
Enzyme Commission (EC)	Isomerases	0.3969	Least Informative	Inherited
Enzyme Commission (EC)	Lyases	1	Least Informative	Inherited
Enzyme Commission (EC)	Acting on ester bonds	0.6299	Least Informative	Inherited
Enzyme Commission (EC)	Oxidoreductases	0.1608	Least Informative	Inherited
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	Moderately Informative	Direct
Enzyme Commission (EC)	Ligases forming aminoacyl-tRNA and related compoun	0	Moderately Informative	Direct
Enzyme Commission (EC)	Racemases and epimerases	1.226e-05	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on the CH-NH group of donors	0.0001655	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	0.0006292	Moderately Informative	Direct
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Hydro-lyases	0.2262	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on the CH-CH group of donors	0.00186	Moderately Informative	Inherited
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.191	Moderately Informative	Inherited
Enzyme Commission (EC)	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat	0	Informative	Direct
Enzyme Commission (EC)	Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s	2.368e-16	Informative	Direct
Enzyme Commission (EC)	Fatty-acid synthase	6.478e-14	Informative	Direct
Enzyme Commission (EC)	[Acyl-carrier-protein] S-acetyltransferase	4.563e-11	Informative	Direct
Enzyme Commission (EC)	Thiolester hydrolases	2.007e-07	Informative	Direct
Enzyme Commission (EC)	Acting on amino acids and derivatives	2.175e-07	Informative	Direct
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	5.191e-05	Informative	Direct
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.0001778	Informative	Direct
Enzyme Commission (EC)	Acid--D-amino-acid ligases (peptide synthases)	0.01316	Informative	Inherited
Enzyme Commission (EC)	Beta-ketoacyl-acyl-carrier-protein synthase I	0	Highly Informative	Direct
Enzyme Commission (EC)	L-aminoadipate-semialdehyde dehydrogenase	0	Highly Informative	Direct
Enzyme Commission (EC)	Formyltetrahydrofolate dehydrogenase	0	Highly Informative	Direct
Enzyme Commission (EC)	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin	0	Highly Informative	Direct
Enzyme Commission (EC)	Phenylalanine racemase (ATP-hydrolyzing)	2.79e-13	Highly Informative	Direct
Enzyme Commission (EC)	3-oxoacyl-[acyl-carrier-protein] reductase	1.391e-12	Highly Informative	Direct
Enzyme Commission (EC)	[Acyl-carrier-protein] S-malonyltransferase	5.831e-08	Highly Informative	Direct

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)

	FA term	FDR (all)	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organ system	0	Least Informative	Direct

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)

	AP term	FDR (all)	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	microsporophyll	0	Least Informative	Direct
Plant ANatomical entity (PAN)	sporangium	0	Least Informative	Direct
Plant ANatomical entity (PAN)	microgametophyte	0	Least Informative	Direct

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Oxidoreductases	0.1594	Least Informative	Inherited
Enzyme Commission (EC)	Hydrolases	1	Least Informative	Inherited
Enzyme Commission (EC)	Lyases	1	Least Informative	Inherited
Enzyme Commission (EC)	Acyltransferases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Ligases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0.3747	Moderately Informative	Inherited
Enzyme Commission (EC)	Isomerases	0.4091	Moderately Informative	Inherited
Enzyme Commission (EC)	Carbon-oxygen lyases	0.4799	Moderately Informative	Inherited
Enzyme Commission (EC)	Ligases forming aminoacyl-tRNA and related compounds	0	Informative	Direct
Enzyme Commission (EC)	Racemases and epimerases	1.868e-05	Informative	Direct
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	2.675e-05	Informative	Direct
Enzyme Commission (EC)	Acting on the CH-NH group of donors	0.0001527	Informative	Direct
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	0.0006303	Informative	Direct
Enzyme Commission (EC)	Acid--D-amino-acid ligases (peptide synthases)	0.01237	Informative	Inherited
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.1562	Informative	Inherited
Enzyme Commission (EC)	Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)	0	Highly Informative	Direct
Enzyme Commission (EC)	Beta-ketoacyl-[acyl-carrier-protein] synthase I	0	Highly Informative	Direct
Enzyme Commission (EC)	Oleoyl-[acyl-carrier-protein] hydrolase	2.359e-15	Highly Informative	Direct
Enzyme Commission (EC)	Fatty-acid synthase	5.539e-14	Highly Informative	Direct
Enzyme Commission (EC)	3-oxoacyl-[acyl-carrier-protein] reductase	1.958e-12	Highly Informative	Direct
Enzyme Commission (EC)	[Acyl-carrier-protein] S-acetyltransferase	4.018e-11	Highly Informative	Direct
Enzyme Commission (EC)	[Acyl-carrier-protein] S-malonyltransferase	5.136e-08	Highly Informative	Direct
Enzyme Commission (EC)	Acting on amino acids and derivatives	1.938e-07	Highly Informative	Direct
Enzyme Commission (EC)	Acting on ether bonds	1.159e-06	Highly Informative	Direct

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Lipid metabolism	0	Moderately Informative	Direct
Biological process	Fatty acid metabolism	0	Informative	Direct
Biological process	Lipid biosynthesis	0	Informative	Direct
Biological process	Cell wall biogenesis/degradation	7.423e-12	Informative	Direct
Biological process	Virulence	1.821e-07	Informative	Direct
Biological process	Cell shape	5.362e-06	Informative	Direct
Biological process	Antibiotic biosynthesis	0	Highly Informative	Direct
Cellular component	Cytoplasm	0	Least Informative	Direct
Domain	Transit peptide	2.085e-08	Moderately Informative	Direct
Molecular function	Phosphopantetheine	0	Highly Informative	Direct
Post-translational modification	Transferase	1	Least Informative	Inherited
Post-translational modification	Ligase	0	Moderately Informative	Direct
Post-translational modification	Acyltransferase	0.0004819	Informative	Direct

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)

	UP term	FDR (all)	SDUP level	Annotation (direct or inherited)
UniPathway (UP)	lipid metabolism	0	Least Informative	Direct
UniPathway (UP)	amino-acid metabolism	1	Least Informative	Inherited
UniPathway (UP)	fatty acid metabolism	0	Moderately Informative	Direct
UniPathway (UP)	lipid biosynthesis	0	Moderately Informative	Direct
UniPathway (UP)	secondary metabolite metabolism	1.03e-07	Moderately Informative	Direct
UniPathway (UP)	cell wall metabolism	3.59e-05	Moderately Informative	Direct
UniPathway (UP)	cellular component biogenesis	0.3416	Moderately Informative	Inherited
UniPathway (UP)	proteinogenic amino-acid biosynthesis	1	Moderately Informative	Inherited
UniPathway (UP)	fatty acid biosynthesis	0	Informative	Direct
UniPathway (UP)	antibiotic biosynthesis	0	Informative	Direct
UniPathway (UP)	siderophore metabolism	0	Informative	Direct
UniPathway (UP)	polyketide biosynthesis	3.715e-13	Informative	Direct
UniPathway (UP)	toxin biosynthesis	1.25e-05	Informative	Direct
UniPathway (UP)	L-lysine biosynthesis	1	Informative	Inherited
UniPathway (UP)	glycolipid biosynthesis	1	Informative	Inherited
UniPathway (UP)	lipoteichoic acid biosynthesis	0	Highly Informative	Direct
UniPathway (UP)	penicillin G biosynthesis	1.209e-09	Highly Informative	Direct
UniPathway (UP)	mycotoxin biosynthesis	3.705e-06	Highly Informative	Direct
UniPathway (UP)	L-lysine biosynthesis via AAA pathway	6.029e-06	Highly Informative	Direct
UniPathway (UP)	gramicidin S biosynthesis	4.23e-05	Highly Informative	Direct

Document: UP annotation of SCOP domains

InterPro annotation

Cross references IPR009081 SSF47336 Protein matches

Abstract
Acyl carrier protein (ACP) is an essential cofactor in the synthesis of fatty acids by the fatty acid synthetases systems in bacteria and plants. In addition to fatty acid synthesis, ACP is also involved in many other reactions that require acyl transfer steps, such as the synthesis of polyketide antibiotics, biotin precursor, membrane-derived oligosaccharides, and activation of toxins, and functions as an essential cofactor in lipoylation of pyruvate and alpha-ketoglutarate dehydrogenase complexes [ PubMed 12057197]. The core structure of ACP consists of a four-helical bundle, where helix three is shorter than the others.

Several other proteins share structural homology with ACP, such as the bacterial apo-D-alanyl carrier protein, which facilitates the incorporation of D-alanine into lipoteichoic acid by a ligase, necessary for the growth and development of Gram-positive organisms [ PubMed 11434765]; and the thioester domain of the bacterial peptide carrier protein found within large modular non-ribosomal peptide synthetases, which are responsible for the synthesis of a variety of microbial bioactive peptides [ PubMed 10801488].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a ACP-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the ACP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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ACP-like superfamily