SUPERFAMILY 1.75 HMM library and genome assignments server


ACP-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl carrier protein-like [ 47335] (3)
Superfamily:   ACP-like [ 47336] (3)
Families:   Acyl-carrier protein (ACP) [ 47337] (6)
  Peptidyl carrier domain [ 47342]
  apo-D-alanyl carrier protein [ 63535]


Superfamily statistics
Genomes (2,978) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 32,358 65,552 17
Proteins 21,613 47,119 17


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00014950.007299Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0013350Least InformativeInherited
Biological Process (BP)single-organism biosynthetic process1.201e-071.333e-10Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process5.821e-060.0009375Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process9.712e-052.652e-05Moderately InformativeDirect
Biological Process (BP)lipid biosynthetic process0.00057455.965e-09Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process6.244e-084.846e-08InformativeDirect
Biological Process (BP)fatty acid metabolic process7.229e-089.239e-10InformativeDirect
Molecular Function (MF)binding0.059671Least InformativeInherited
Molecular Function (MF)cofactor binding1.813e-105.929e-10InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.8824 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.4633 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.007299 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1.333e-10 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0009375 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 2.652e-05 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 5.965e-09 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 1.619e-08 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 4.317e-07 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 2.289e-06 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.000429 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.07694 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.001274 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.07926 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.02483 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9674 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9153 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 4.846e-08 Informative Direct
Biological Process (BP) fatty acid metabolic process 9.239e-10 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 7.376e-11 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 2.364e-08 Informative Direct
Biological Process (BP) alcohol metabolic process 0.3446 Informative Inherited
Biological Process (BP) pigment metabolic process 0.2227 Informative Inherited
Biological Process (BP) response to nutrient levels 0.02075 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.4223 Informative Inherited
Biological Process (BP) cation homeostasis 0.4313 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.02007 Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) amide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 1.169e-11 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 6.775e-10 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 2.535e-05 Highly Informative Direct
Biological Process (BP) pathogenesis 2.892e-05 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 8.057e-05 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0001397 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.0002306 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.05707 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.1651 Highly Informative Inherited
Biological Process (BP) toxin metabolic process 0.002129 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.005379 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.007339 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.5156 Moderately Informative Inherited
Molecular Function (MF) cofactor binding 5.929e-10 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.002829 Informative Inherited
Molecular Function (MF) NADH dehydrogenase activity 3.543e-08 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 5.321e-05 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) external encapsulating structure 0.00367 Informative Inherited
Cellular Component (CC) cell wall 0.0004237 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3969Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.6299Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1608Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases1.226e-05Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001655Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0006292Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.2262Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00186Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.191Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s2.368e-16InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase6.478e-14InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase4.563e-11InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases2.007e-07InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives2.175e-07InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor5.191e-05InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0001778InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.01316InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0Highly InformativeDirect
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Formyltetrahydrofolate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)2.79e-13Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase1.391e-12Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase5.831e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.1334Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.4108Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.4152Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.4904Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases2.011e-05InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor3.01e-05InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001703InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0001805InformativeDirect
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.01282InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.1624InformativeInherited
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase2.381e-15Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase6.643e-14Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase2.042e-12Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase4.658e-11Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase5.924e-08Highly InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives2.06e-07Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds1.258e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processCell wall biogenesis/degradation9.222e-12InformativeDirect
Biological processVirulence1.129e-08InformativeDirect
Biological processCell shape5.596e-06InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainTransit peptide4.645e-08Moderately InformativeDirect
Molecular functionNADP2.97e-08InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis3.815e-06Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.246Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)cell wall biogenesis1.902e-15InformativeDirect
UniPathway (UP)polyketide biosynthesis3.888e-09InformativeDirect
UniPathway (UP)siderophore metabolism8.032e-09InformativeDirect
UniPathway (UP)beta-lactam biosynthesis0.2145InformativeInherited
UniPathway (UP)glycolipid biosynthesis1InformativeInherited
UniPathway (UP)lipoteichoic acid biosynthesis0Highly InformativeDirect
UniPathway (UP)penicillin G biosynthesis2.571e-10Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR009081 SSF47336 Protein matches
Abstract

Acyl carrier protein (ACP) is an essential cofactor in the synthesis of fatty acids by the fatty acid synthetases systems in bacteria and plants. In addition to fatty acid synthesis, ACP is also involved in many other reactions that require acyl transfer steps, such as the synthesis of polyketide antibiotics, biotin precursor, membrane-derived oligosaccharides, and activation of toxins, and functions as an essential cofactor in lipoylation of pyruvate and alpha-ketoglutarate dehydrogenase complexes [PubMed12057197]. The core structure of ACP consists of a four-helical bundle, where helix three is shorter than the others.

Several other proteins share structural homology with ACP, such as the bacterial apo-D-alanyl carrier protein, which facilitates the incorporation of D-alanine into lipoteichoic acid by a ligase, necessary for the growth and development of Gram-positive organisms [PubMed11434765]; and the thioester domain of the bacterial peptide carrier protein found within large modular non-ribosomal peptide synthetases, which are responsible for the synthesis of a variety of microbial bioactive peptides [PubMed10801488].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACP-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the ACP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]